AutismKB 2.0

Annotation Detail for S1PR1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:S1PR1 ( CHEDG1,D1S3362,ECGF1,EDG-1,EDG1,FLJ58121,S1P1 )
Gene Full Name: sphingosine-1-phosphate receptor 1
Band: 1p21.2
Quick LinksEntrez ID:1901; OMIM: 601974; Uniprot ID:S1PR1_HUMAN; ENSEMBL ID: ENSG00000170989; HGNC ID: 3165
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200035S1P3 pathway
200003Fc-epsilon receptor I signaling in mast cells
200127PDGFR-beta signaling pathway
200071S1P1 pathway
200161Signaling events mediated by VEGFR1 and VEGFR2
200104Sphingosine 1-phosphate (S1P) pathway
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of S1PR1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of S1PR1 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone affects the expression of S1PR1 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of S1PR1 mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of S1PR1 mRNAaffects expression 19483382
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of S1PR1 mRNAaffects cotreatment|decreases expression 18164116
D002994 Clofibrate Clofibrate affects the expression of S1PR1 mRNAaffects expression 19483382
D002995 Clofibric Acid Clofibric Acid affects the expression of S1PR1 mRNAaffects expression 17602206
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of S1PR1 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of S1PR1 mRNAdecreases expression 20106945
C014347 decitabine [decitabine co-treated with trichostatin A] affects the expression of S1PR1 mRNAaffects cotreatment|affects expression 17189669
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of S1PR1 mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of S1PR1 mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of S1PR1 mRNAdecreases expression 17606305
D005001 Ethionine Ethionine affects the expression of S1PR1 mRNAaffects expression 19483382
D005665 Furosemide Furosemide results in increased expression of S1PR1 mRNAincreases expression 16526316
D009853 Omeprazole Omeprazole affects the expression of S1PR1 mRNAaffects expression 19483382
D010634 Phenobarbital Phenobarbital results in increased expression of S1PR1 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid affects the expression of S1PR1 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of S1PR1 mRNAaffects expression 19483382
C009250 sevoflurane sevoflurane affects the expression of S1PR1 mRNAaffects expression 15967596
C017947 sodium arsenite S1PR1 protein affects the reaction [sodium arsenite results in increased activity of RAC1 protein]affects reaction|increases activity 19349368
C017947 sodium arsenite S1PR1 protein affects the reaction [sodium arsenite results in increased expression of HGF mRNA]affects reaction|increases expression 19349368
C017947 sodium arsenite S1PR1 protein affects the reaction [sodium arsenite results in increased expression of IGF1 mRNA]affects reaction|increases expression 19349368
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of S1PR1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of S1PR1 mRNAincreases expression 17337447
D013853 Thioacetamide Thioacetamide affects the expression of S1PR1 mRNAaffects expression 19483382
C012589 trichostatin A [decitabine co-treated with trichostatin A] affects the expression of S1PR1 mRNAaffects cotreatment|affects expression 17189669
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.796195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7915322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7814692618
MESH:D000236 Adenoma beta-Naphthoflavone 6.5919389873
MESH:D000236 Adenoma Diethylnitrosamine 6.596695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.6117162532 19052882 18056438 19061943 16434500 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.6117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.6116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.6116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7516712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6718218290 20041841 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5715885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.7919698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 55.7019483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 55.7019483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 55.7019483382
MESH:D001778 Blood Coagulation Disorders Ethionine 55.7019483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 55.7019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 55.7019483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 55.7019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 55.7012125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 55.7019483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D001943 Breast Neoplasms decitabine 1.8818320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8817474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.723084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.7221507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 13.721701930
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.7218056438 20935162 16502159 16779866 10737359 19519916 16681979 19335982 18393292 16540662 10672840 19394651 18788625 20007298 18978308 17428255 18691550 3581430 17055752 18506893 19208518 17138121 17162532 11831363 18494052 20524982 19701751 17978847 18665156 16830150 16328049 16288022 19107877 21159647 16878318 16807293 18971187 20084675 18210153 18785209 20727157 17173139 19052882 19822196 16569478 16698587 19539802 19171122 20432363 19418558 3084413 20101231 20514400 19383236 20512989 19919837 20214788 16935385 17761372
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.7220007298 1701930 6705139 20935162 17173139
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.7215276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 13.7217997003
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.6519215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.6518572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8415710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.9318974383
MESH:D002386 Cataract Acetaminophen 2.4910977129
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 15.201399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.2012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.2017174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.2019524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.104080065
MESH:D002637 Chest Pain Omeprazole 4.9615447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 15.3719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 15.3716835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 15.3718291259
MESH:D002779 Cholestasis Cyclosporine 12.6919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.6916105132 17333356 17110522 16919318 15861022 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 12.6919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.048697196 15668235 16354765 12621046 15340226
MESH:D003110 Colonic Neoplasms decitabine 2.3117616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0920387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.5316109766 12540782 19420014 16393943 15968718 16781746 11421492 12594235 16227642 11529661 11834606 2444490 10774834 19923254 16081117 11287661 12958197 18071297 17522070 14725611 15619225 11461765 16177239 19370779 17906064 10663392 19085960 16485898 14986274 14550746 19164858 12705907 18713872 19416960 11743745 12153990 11739529 17562736 19739265 10915739 12392966
MESH:D056486 Drug-Induced Liver Injury Amiodarone 11.5315265979 18218290
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.5319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.5320420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 11.5312963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.1817151854 16613094 15991576 21218061
MESH:D050171 Dyslipidemias Clofibrate 3.9616707586
MESH:D004417 Dyspnea Furosemide 4.7916935035
MESH:D004421 Dystonia Phenobarbital 3.861851702
MESH:D004487 Edema Furosemide 10.7211834646
MESH:D004487 Edema pirinixic acid 10.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.7211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0412538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.5219294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.5219294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.899294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.963659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.723922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.416401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.107750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.873659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9716302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005218 Fat Necrosis Thioacetamide 5.5716456712
MESH:D005234 Fatty Liver Amiodarone 28.9214986274
MESH:D005234 Fatty Liver Clofibrate 28.9219224547
MESH:D005234 Fatty Liver Cyclosporine 28.9219224547
MESH:D005234 Fatty Liver Diethylnitrosamine 28.9221071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.9215345470
MESH:D005234 Fatty Liver pirinixic acid 28.9220131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005355 Fibrosis Cyclosporine 7.9812168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.9820067830
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D005909 Glioblastoma trichostatin A 3.7318801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.3919215824
MESH:D034381 Hearing Loss Furosemide 4.7017868369
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2511294989 10048152
MESH:D006333 Heart Failure Furosemide 7.0112660669 16011733 16845234
MESH:D006333 Heart Failure pirinixic acid 7.0120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.4315929193 18665440 17276928
MESH:D006505 Hepatitis Thioacetamide 4.0716456712
MESH:D006529 Hepatomegaly Amiodarone 19.4415265979
MESH:D006529 Hepatomegaly Phenobarbital 19.4416109766
MESH:D006529 Hepatomegaly pirinixic acid 19.4418467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 19.4415340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.0312676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8918606429 8697196 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5816870215
MESH:D006934 Hypercalcemia Furosemide 4.9317652376
MESH:D053565 Hypercalciuria Furosemide 5.5017652376
MESH:D006937 Hypercholesterolemia Amiodarone 3.739751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.7215086907
MESH:D006973 Hypertension Cyclosporine 4.7510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7518850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.1316612254
MESH:C537153 Hypomagnesemia primary Furosemide 5.5011041285
MESH:D007019 Hypoproteinemia Furosemide 5.7216096441
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6616945680 16569931
MESH:D007022 Hypotension Furosemide 4.4711041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.2715811171
MESH:D007037 Hypothyroidism Amiodarone 11.1117991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 11.1118031379 8137927
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male decitabine 10.6517581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.6517937319
MESH:D007248 Infertility, Male sodium arsenite 10.6515346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 4.6418785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.6412200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.5316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Acetaminophen 13.7612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 13.768314463 10903974 18776723
MESH:D007674 Kidney Diseases Furosemide 13.7611041285
MESH:D007674 Kidney Diseases sodium arsenite 13.7620008137
MESH:D007680 Kidney Neoplasms Cyclosporine 2.6112371664
MESH:D007859 Learning Disorders sevoflurane 4.6219212262
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.9719248655
MESH:D007938 Leukemia decitabine 3.0018980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 3.8617236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.1818460780 19010910 17679729 18704418 19387464 18206229
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.1818206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3118055864
MESH:D008064 Lipidoses Amiodarone 3.4015342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.3718407596 19638242 18522880 20032147 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 6.3721047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3712878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.3715078482 15362042 15158331 12679928 17292413 16126171 11172339 15465738 16248980 18416461 15288472 18395095 12085344 15075984 18606216 12531686 12891558 17127702 18458672 14739098 15716488 11682029 18615449 11481614 15316131 16098781 12557150 17050028 12175628 15288473 15095483 15334695 16511523 18263696 16489207 17355460 16343077 16097051 18295389 18380797 18032466 10677585 15474484 18031379 17629604
MESH:D008107 Liver Diseases Acetaminophen 9.0712969438 19460945 19784758 11587558 19014921 16611625 12587719 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 9.0717034775
MESH:D008107 Liver Diseases Phenobarbital 9.0719363144
MESH:D008107 Liver Diseases Thioacetamide 9.0715158337 16337175 18374380
MESH:D017114 Liver Failure, Acute Acetaminophen 9.1917185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 9.1915313186 17276928 15633222 12479984
MESH:D008113 Liver Neoplasms Aflatoxin B1 24.982125692 9163691 15890375 18177683
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 24.9819389873 21295105
MESH:D008113 Liver Neoplasms Clofibric Acid 24.9817602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.982422723 19427195 20118626 12771043 15885732 20137499 15175105 19642983 19850985 20583210 19690152 20492335 19426721 12112319 19254457 16942905 2862719 10737359 18978307 9163691 18648771 19255062 20452335 19833225 20434301 19996281 19551842 20405173 20101389 19256749 18644402 19073162 18977376 21278145 18754104 21047994 19294768 21071580 20501860 19499222 19812893 21167192 19090486 19638242
MESH:D008113 Liver Neoplasms Phenobarbital 24.988742319 19482888 19073162 21047994 19812893 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 24.9816377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 24.9816712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.9816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.658603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 17.6518164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.6518775883 2563599 17942915 21159647 18282651 17854601 18308698 19004024 19519916 19009564 18253720 16842330 18164116 19539802 3124819 18079962 18093689 16267830 19126423 9362446 18544905 17174075
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 17.6517172636 1399818 6150874 2563599 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.6512151625
MESH:D008133 Long QT Syndrome Amiodarone 3.4615350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 7.1812587719
MESH:D008171 Lung Diseases sodium arsenite 7.1819095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.3318516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.6914755239
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.6920970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms sodium arsenite 4.6916712894 17306315 17077188 15276417 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6911884234 19555203
MESH:D008223 Lymphoma decitabine 3.3119470736
MESH:D008545 Melanoma decitabine 5.1016505122 17785578
MESH:D008545 Melanoma sodium arsenite 5.1019082730 16487513
MESH:D008545 Melanoma trichostatin A 5.1016505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008569 Memory Disorders sevoflurane 4.6019212262
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D009101 Multiple Myeloma decitabine 7.3018172295
MESH:D009101 Multiple Myeloma trichostatin A 7.3018172295
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009181 Mycoses Amiodarone 4.7512754197 17974566
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3018608210 19157545 19010910 16882708
MESH:D009203 Myocardial Infarction pirinixic acid 2.0819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3217484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.519029167 3581430
MESH:D009369 Neoplasms decitabine 7.8419470736 17925555 19116145
MESH:D009369 Neoplasms pirinixic acid 7.8417405874
MESH:D009369 Neoplasms sodium arsenite 7.8411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5220056578
MESH:D009397 Nephrocalcinosis Furosemide 5.7215086907
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1519348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0714600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.0512854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.7718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.7720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9720387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.799802331
MESH:D053206 Nocturnal Enuresis Furosemide 5.7217945291
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D010018 Osteomalacia Phenobarbital 4.2117016548
MESH:D010051 Ovarian Neoplasms decitabine 7.7719259094 19331143
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.7715276417 17306315
MESH:D010051 Ovarian Neoplasms trichostatin A 7.7719331143
MESH:D010146 Pain Acetaminophen 2.2716870215
MESH:D010190 Pancreatic Neoplasms decitabine 11.9319294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.9316540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.9316965848
MESH:D010190 Pancreatic Neoplasms trichostatin A 11.9319294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D011141 Polyuria Furosemide 5.5017945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.5212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.522563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.522563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0411896295 11222880 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 11.9217616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.9217616702
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.6316039940
MESH:D011471 Prostatic Neoplasms trichostatin A 3.6318798265 19789329
MESH:D011537 Pruritus Ethinyl Estradiol 3.1615861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.3412752131
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8011597910 12832656 12490602
MESH:D015427 Reperfusion Injury Furosemide 6.5616526316
MESH:D015427 Reperfusion Injury pirinixic acid 6.5619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.4715912074 12394941 16096441
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.2619155313
MESH:D012640 Seizures Phenobarbital 2.594039156 3137016 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.676407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.9318724381
MESH:D012878 Skin Neoplasms sodium arsenite 5.3619524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7916709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6812854658
MESH:D013272 Stomach Diseases Omeprazole 4.4618545984
MESH:D013274 Stomach Neoplasms decitabine 3.4619037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4618456281
MESH:D013274 Stomach Neoplasms Furosemide 3.4617052386
MESH:D013276 Stomach Ulcer Amiodarone 7.1218087811
MESH:D013276 Stomach Ulcer Omeprazole 7.1218237397 11906479 10750652 17977527 15991576 16755016
MESH:D013610 Tachycardia Amiodarone 4.1411238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0419225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013959 Thyroid Diseases Amiodarone 11.5519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.5512697716
MESH:D013964 Thyroid Neoplasms decitabine 16.2017967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 16.207505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 16.201399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 16.2015710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.7118020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.0411989578 17467628
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.0617616700 19087683
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.0617306315 16452187 16712894 11723127
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.6311813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1514692618
MESH:D014604 Uveal Neoplasms decitabine 4.7617785578
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4014671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162402344
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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