AutismKB 2.0

Annotation Detail for HIGD2A


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Basic Information Top
Gene Symbol:HIGD2A ( MGC2198 )
Gene Full Name: HIG1 hypoxia inducible domain family, member 2A
Band: 5q35.2
Quick LinksEntrez ID:192286; OMIM: NA; Uniprot ID:HIG2A_HUMAN; ENSEMBL ID: ENSG00000146066; HGNC ID: 28311
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of HIGD2A mRNAaffects expression 17484886
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HIGD2A mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HIGD2A mRNAaffects cotreatment|affects expression 17602206
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of HIGD2A mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of HIGD2A mRNAaffects cotreatment|increases expression 17183730
D014810 Vitamin E Vitamin E results in increased expression of HIGD2A mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2519490988
MESH:D000236 Adenoma Diethylnitrosamine 3.016695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3618056438 19061943 17162532 17620307 16434500 19052882
MESH:D000550 Amblyopia Valproic Acid 5.7517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8317497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9920603192 18396377 18985861 16609825 18316065 18775368 18558336 19232924 17507914 18177632 15238991 17688650 18940202 19460635 17157402
MESH:D001714 Bipolar Disorder Valproic Acid 3.2117594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.598888407
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 11.3616124888 15700767 16050911 16227642 16097048 15673190 16192424 15721981 10355542 3786805 16011737 18705752
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 11.3616050911
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1319822196 3084413 3581430 16935385 20524982 18506893 17162532 20514400 20101231 10672840 18691550 17978847 20007298 16878318 18056438 18788625 16807293 17173139 18971187 17761372 19394651 18785209 16681979 19052882 17428255 16328049 20935162 20214788 20432363 17055752 18494052 19208518 19519916 19919837 20084675 20727157 19418558 17138121 11831363 18210153 19335982 19539802 16779866 18393292 18665156 16569478 21159647 16288022 10737359 19701751 19383236 19171122 19107877 16502159 18978308 16698587 16830150 16540662 20512989
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.062727394 17174075 21159647 7505956
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8020734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9719052882
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7916575769 8888407 17688650
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7919769572
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2520387270
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.739327722 6623471 16177239 6884620 4309450 19336974 21278145 7120509 19085960 2869522 15968718 15027814 10915739 3732212 17522070 3786805 16227642 11566570 7440962 15998439 7179309 10092053
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.7319107877
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.731733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.401851702
MESH:C538011 Eales disease Vitamin E 5.229068938
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.443922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.876426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.533659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.6416302075
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.1319224547 15959796 16045604 12631006 61145 12795759 17595544 16239168
MESH:D005234 Fatty Liver Diethylnitrosamine 15.1321071580 20387270
MESH:D005234 Fatty Liver Valproic Acid 15.1314986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.4116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.518888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 3.8718705752
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1316080930
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719110552 19900420
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7916863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.4914716179
MESH:D006849 Hydrocephalus Valproic Acid 5.3317688650
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.0416612254
MESH:D007249 Inflammation Diethylnitrosamine 2.5218785209
MESH:D007251 Influenza, Human Vitamin E 4.7316624496
MESH:D007674 Kidney Diseases Vitamin E 2.9612488133
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.1311903743 16943688 17174718 11408273 17157831 16221502 16239168 17334410 21278145
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.1320032147 18407596 18522880 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.6017714472 17976157 18006644 13678700 18277467 16033810 14620537 18205269 12632514 17900296 15370692 17766677 12546737 17944888 15931870 16097048 15818738 12958196 17823541 20821823 15338365 10355542 12445418 14724832 12898905 17721639 18210741 18705752 18481824 15650968 18054572 11481614 18472332 18156304 15673190 17565644 18251166 16116963 15925388 15959796 14716496 17640975 12649538 12445421 17761835 14716833 12389079 18263696 17708605 15876570 14748882 18317297 17557913 18279442 12666154 15893842 18472094 18418968 16638106 16192424 14512876 12632512 17805973 17631135 16136751 17525996 17698563 12667390 18412020 12609069 16248980 15057751 18166357 18395095 18395914 15052691 15730626 18420326 17869086 16011737 16015684 18187930 17922224 15996030 17481882 16027843 18429990 12586293 18339082 15362042 15123356 18376398 12741479
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.6016169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2915720792 16246199 16964402 15830285 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 4.2917034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9916899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.1119294768
MESH:D008113 Liver Neoplasms Clofibric Acid 8.1117602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.1120137499 20405173 19638242 20501860 20101389 21071580 20452335 16942905 12112319 15885732 21047994 19642983 19812893 19090486 19690152 9163691 18977376 10737359 18754104 19427195 19499222 2862719 19426721 2422723 18644402 19256749 15175105 19833225 12771043 19073162 19254457 19551842 21278145 20492335 19294768 20118626 18648771 18978307 19850985 20434301 19255062 20583210 21167192 19996281
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.5612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.5617174075 3124819 21159647 18079962 19126423 18775883 19519916 16267830 18093689 18544905 18164116 19009564 9362446 19539802 18253720 18282651 17942915 17854601 19004024 18308698 2563599 16842330
MESH:D008171 Lung Diseases Vitamin E 3.3716863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7817228818
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5720970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Vitamin E 2.5711062179
MESH:D008881 Migraine Disorders Valproic Acid 3.4118765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.358888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3117596541
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.679029167 3581430
MESH:D009436 Neural Tube Defects Valproic Acid 3.3216359493 8888407
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.6420387270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5116540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.842563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2920603192
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2515084515
MESH:D019310 Pseudolymphoma Valproic Acid 5.0611422049 12752131
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5319155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.943137016 17978042 1511512 11738929 11044598 15475178 14763951 16876388
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0219490988
MESH:D013226 Status Epilepticus Valproic Acid 5.0612833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Vitamin E 3.7716517955
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.227505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.7517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.983119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.068888407
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018