Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
---|
D002251 |
Carbon Tetrachloride |
Carbon Tetrachloride affects the expression of HIGD2A mRNA | affects expression | 17484886
|
D002995 |
Clofibric Acid |
[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HIGD2A mRNA | affects cotreatment|affects expression | 17602206
|
D004052 |
Diethylnitrosamine |
[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HIGD2A mRNA | affects cotreatment|affects expression | 17602206
|
D006830 |
Hydralazine |
[Hydralazine co-treated with Valproic Acid] results in increased expression of HIGD2A mRNA | affects cotreatment|increases expression | 17183730
|
D014635 |
Valproic Acid |
[Hydralazine co-treated with Valproic Acid] results in increased expression of HIGD2A mRNA | affects cotreatment|increases expression | 17183730
|
D014810 |
Vitamin E |
Vitamin E results in increased expression of HIGD2A mRNA | increases expression | 19244175
|
Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
---|
MESH:D000014 |
Abnormalities, Drug-Induced |
|
Valproic Acid |
3.95 | 8875741 |
MESH:D000015 |
Abnormalities, Multiple |
|
Valproic Acid |
4.25 | 19490988 |
MESH:D000236 |
Adenoma |
|
Diethylnitrosamine |
3.01 | 6695378 10737359 |
MESH:D018248 |
Adenoma, Liver Cell |
|
Diethylnitrosamine |
4.36 | 18056438 19061943 17162532 17620307 16434500 19052882 |
MESH:D000550 |
Amblyopia |
|
Valproic Acid |
5.75 | 17688650 |
MESH:D001008 |
Anxiety Disorders |
|
Valproic Acid |
3.83 | 17497229 |
MESH:D001321 |
Autistic Disorder |
|
Valproic Acid |
1.99 | 20603192 18396377 18985861 16609825 18316065 18775368 18558336 19232924 17507914 18177632 15238991 17688650 18940202 19460635 17157402 |
MESH:D001714 |
Bipolar Disorder |
|
Valproic Acid |
3.21 | 17594078 20046352 |
MESH:D001848 |
Bone Diseases, Developmental |
|
Valproic Acid |
3.59 | 8888407 |
MESH:D001943 |
Breast Neoplasms |
|
Diethylnitrosamine |
2.20 | 17474063 |
MESH:D002252 |
Carbon Tetrachloride Poisoning |
|
Carbon Tetrachloride |
11.36 | 16124888 15700767 16050911 16227642 16097048 15673190 16192424 15721981 10355542 3786805 16011737 18705752 |
MESH:D002252 |
Carbon Tetrachloride Poisoning |
|
Vitamin E |
11.36 | 16050911 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Carbon Tetrachloride |
3.13 | 18788625 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Diethylnitrosamine |
3.13 | 19822196 3084413 3581430 16935385 20524982 18506893 17162532 20514400 20101231 10672840 18691550 17978847 20007298 16878318 18056438 18788625 16807293 17173139 18971187 17761372 19394651 18785209 16681979 19052882 17428255 16328049 20935162 20214788 20432363 17055752 18494052 19208518 19519916 19919837 20084675 20727157 19418558 17138121 11831363 18210153 19335982 19539802 16779866 18393292 18665156 16569478 21159647 16288022 10737359 19701751 19383236 19171122 19107877 16502159 18978308 16698587 16830150 16540662 20512989 |
MESH:D002471 |
Cell Transformation, Neoplastic |
|
Diethylnitrosamine |
3.06 | 2727394 17174075 21159647 7505956 |
MESH:D002659 |
Child Development Disorders, Pervasive |
|
Valproic Acid |
2.80 | 20734317 |
MESH:D018281 |
Cholangiocarcinoma |
|
Diethylnitrosamine |
3.97 | 19052882 |
MESH:D019465 |
Craniofacial Abnormalities |
|
Valproic Acid |
2.79 | 16575769 8888407 17688650 |
MESH:D019465 |
Craniofacial Abnormalities |
|
Vitamin E |
2.79 | 19769572 |
MESH:D003924 |
Diabetes Mellitus, Type 2 |
|
Diethylnitrosamine |
2.25 | 20387270 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Carbon Tetrachloride |
6.73 | 9327722 6623471 16177239 6884620 4309450 19336974 21278145 7120509 19085960 2869522 15968718 15027814 10915739 3732212 17522070 3786805 16227642 11566570 7440962 15998439 7179309 10092053 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Diethylnitrosamine |
6.73 | 19107877 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Valproic Acid |
6.73 | 1733752 19641884 |
MESH:D004421 |
Dystonia |
|
Valproic Acid |
4.40 | 1851702 |
MESH:C538011 |
Eales disease |
|
Vitamin E |
5.22 | 9068938 |
MESH:D004831 |
Epilepsies, Myoclonic |
|
Valproic Acid |
4.57 | 17275665 3659116 |
MESH:D004828 |
Epilepsies, Partial |
|
Valproic Acid |
4.44 | 3922381 16628512 |
MESH:D004827 |
Epilepsy |
|
Valproic Acid |
3.07 | 20417680 18234410 |
MESH:D004832 |
Epilepsy, Absence |
|
Valproic Acid |
3.87 | 6426943 7562514 6254150 |
MESH:D017029 |
Epilepsy, Complex Partial |
|
Valproic Acid |
4.71 | 7750514 |
MESH:D004830 |
Epilepsy, Tonic-Clonic |
|
Valproic Acid |
4.53 | 3659116 |
MESH:D004931 |
Esophageal Achalasia |
|
Diethylnitrosamine |
5.64 | 16302075 |
MESH:D005234 |
Fatty Liver |
|
Carbon Tetrachloride |
15.13 | 19224547 15959796 16045604 12631006 61145 12795759 17595544 16239168 |
MESH:D005234 |
Fatty Liver |
|
Diethylnitrosamine |
15.13 | 21071580 20387270 |
MESH:D005234 |
Fatty Liver |
|
Valproic Acid |
15.13 | 14986274 19224547 |
MESH:D005315 |
Fetal Diseases |
|
Valproic Acid |
5.41 | 16575769 |
MESH:D005317 |
Fetal Growth Retardation |
|
Valproic Acid |
4.51 | 8888407 18558336 |
MESH:D005355 |
Fibrosis |
|
Carbon Tetrachloride |
3.87 | 18705752 |
MESH:D006330 |
Heart Defects, Congenital |
|
Vitamin E |
3.13 | 16080930 |
MESH:D006505 |
Hepatitis |
|
Carbon Tetrachloride |
3.97 | 19110552 19900420 |
MESH:D006548 |
Hernia, Diaphragmatic |
|
Vitamin E |
2.79 | 16863852 16490937 |
MESH:D019584 |
Hot Flashes |
|
Vitamin E |
4.49 | 14716179 |
MESH:D006849 |
Hydrocephalus |
|
Valproic Acid |
5.33 | 17688650 |
MESH:D006932 |
Hyperbilirubinemia |
|
Carbon Tetrachloride |
4.99 | 16899240 |
MESH:D006975 |
Hypertension, Portal |
|
Carbon Tetrachloride |
4.50 | 15338365 |
MESH:D046110 |
Hypertension, Pregnancy-Induced |
|
Hydralazine |
5.04 | 16612254 |
MESH:D007249 |
Inflammation |
|
Diethylnitrosamine |
2.52 | 18785209 |
MESH:D007251 |
Influenza, Human |
|
Vitamin E |
4.73 | 16624496 |
MESH:D007674 |
Kidney Diseases |
|
Vitamin E |
2.96 | 12488133 |
MESH:D015470 |
Leukemia, Myeloid, Acute |
|
Valproic Acid |
2.19 | 16294345 17596541 |
MESH:D008103 |
Liver Cirrhosis |
|
Carbon Tetrachloride |
7.13 | 11903743 16943688 17174718 11408273 17157831 16221502 16239168 17334410 21278145 |
MESH:D008103 |
Liver Cirrhosis |
|
Diethylnitrosamine |
7.13 | 20032147 18407596 18522880 19638242 18665156 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Carbon Tetrachloride |
2.60 | 17714472 17976157 18006644 13678700 18277467 16033810 14620537 18205269 12632514 17900296 15370692 17766677 12546737 17944888 15931870 16097048 15818738 12958196 17823541 20821823 15338365 10355542 12445418 14724832 12898905 17721639 18210741 18705752 18481824 15650968 18054572 11481614 18472332 18156304 15673190 17565644 18251166 16116963 15925388 15959796 14716496 17640975 12649538 12445421 17761835 14716833 12389079 18263696 17708605 15876570 14748882 18317297 17557913 18279442 12666154 15893842 18472094 18418968 16638106 16192424 14512876 12632512 17805973 17631135 16136751 17525996 17698563 12667390 18412020 12609069 16248980 15057751 18166357 18395095 18395914 15052691 15730626 18420326 17869086 16011737 16015684 18187930 17922224 15996030 17481882 16027843 18429990 12586293 18339082 15362042 15123356 18376398 12741479 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Vitamin E |
2.60 | 16169303 |
MESH:D008107 |
Liver Diseases |
|
Carbon Tetrachloride |
4.29 | 15720792 16246199 16964402 15830285 17285989 |
MESH:D008107 |
Liver Diseases |
|
Diethylnitrosamine |
4.29 | 17034775 |
MESH:D017093 |
Liver Failure |
|
Carbon Tetrachloride |
4.58 | 15123358 |
MESH:D017114 |
Liver Failure, Acute |
|
Carbon Tetrachloride |
3.99 | 16899240 14706259 |
MESH:D008113 |
Liver Neoplasms |
|
Carbon Tetrachloride |
8.11 | 19294768 |
MESH:D008113 |
Liver Neoplasms |
|
Clofibric Acid |
8.11 | 17602206 |
MESH:D008113 |
Liver Neoplasms |
|
Diethylnitrosamine |
8.11 | 20137499 20405173 19638242 20501860 20101389 21071580 20452335 16942905 12112319 15885732 21047994 19642983 19812893 19090486 19690152 9163691 18977376 10737359 18754104 19427195 19499222 2862719 19426721 2422723 18644402 19256749 15175105 19833225 12771043 19073162 19254457 19551842 21278145 20492335 19294768 20118626 18648771 18978307 19850985 20434301 19255062 20583210 21167192 19996281 |
MESH:D008114 |
Liver Neoplasms, Experimental |
|
Carbon Tetrachloride |
6.56 | 12014681 15583823 |
MESH:D008114 |
Liver Neoplasms, Experimental |
|
Diethylnitrosamine |
6.56 | 17174075 3124819 21159647 18079962 19126423 18775883 19519916 16267830 18093689 18544905 18164116 19009564 9362446 19539802 18253720 18282651 17942915 17854601 19004024 18308698 2563599 16842330 |
MESH:D008171 |
Lung Diseases |
|
Vitamin E |
3.37 | 16863852 |
MESH:D017563 |
Lung Diseases, Interstitial |
|
Valproic Acid |
4.78 | 17228818 |
MESH:D008175 |
Lung Neoplasms |
|
Diethylnitrosamine |
2.57 | 20970405 21163286 20512841 6695378 |
MESH:D008175 |
Lung Neoplasms |
|
Vitamin E |
2.57 | 11062179 |
MESH:D008881 |
Migraine Disorders |
|
Valproic Acid |
3.41 | 18765137 18803445 |
MESH:D009139 |
Musculoskeletal Abnormalities |
|
Valproic Acid |
4.35 | 8888407 |
MESH:D009190 |
Myelodysplastic Syndromes |
|
Valproic Acid |
3.31 | 17596541 |
MESH:D009362 |
Neoplasm Metastasis |
|
Diethylnitrosamine |
2.67 | 9029167 3581430 |
MESH:D009436 |
Neural Tube Defects |
|
Valproic Acid |
3.32 | 16359493 8888407 |
MESH:D019636 |
Neurodegenerative Diseases |
|
Diethylnitrosamine |
3.61 | 20387270 |
MESH:D009461 |
Neurologic Manifestations |
|
Diethylnitrosamine |
5.64 | 20387270 |
MESH:D010190 |
Pancreatic Neoplasms |
|
Diethylnitrosamine |
2.51 | 16540662 |
MESH:D011230 |
Precancerous Conditions |
|
Diethylnitrosamine |
3.84 | 2563599 |
MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Valproic Acid |
4.29 | 20603192 |
MESH:D011471 |
Prostatic Neoplasms |
|
Vitamin E |
3.25 | 15084515 |
MESH:D019310 |
Pseudolymphoma |
|
Valproic Acid |
5.06 | 11422049 12752131 |
MESH:D012208 |
Rhabdomyosarcoma |
|
Valproic Acid |
4.53 | 19155313 |
MESH:D012559 |
Schizophrenia |
|
Valproic Acid |
2.10 | 19110320 15737665 |
MESH:D012640 |
Seizures |
|
Valproic Acid |
2.94 | 3137016 17978042 1511512 11738929 11044598 15475178 14763951 16876388 |
MESH:D012871 |
Skin Diseases |
|
Vitamin E |
2.50 | 18709164 |
MESH:D016135 |
Spinal Dysraphism |
|
Valproic Acid |
4.02 | 19490988 |
MESH:D013226 |
Status Epilepticus |
|
Valproic Acid |
5.06 | 12833885 |
MESH:D013274 |
Stomach Neoplasms |
|
Diethylnitrosamine |
1.76 | 18456281 |
MESH:D020521 |
Stroke |
|
Vitamin E |
3.77 | 16517955 |
MESH:D013964 |
Thyroid Neoplasms |
|
Diethylnitrosamine |
3.22 | 7505956 |
MESH:D014178 |
Translocation, Genetic |
|
Valproic Acid |
5.75 | 17262798 |
MESH:D020194 |
Unverricht-Lundborg Syndrome |
|
Valproic Acid |
4.98 | 3119515 |
MESH:D014564 |
Urogenital Abnormalities |
|
Valproic Acid |
5.06 | 8888407 |