AutismKB 2.0

Annotation Detail for EEF1D


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Basic Information Top
Gene Symbol:EEF1D ( EF-1D,EF1D,FLJ20897,FP1047 )
Gene Full Name: eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Band: 8q24.3
Quick LinksEntrez ID:1936; OMIM: 130592; Uniprot ID:EF1D_HUMAN; ENSEMBL ID: ENSG00000104529; HGNC ID: 3211
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Metabolism of proteins
Gene Expression
No data
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Pathway IDPathway Name
500527Eukaryotic Translation Elongation
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1843Metastasis to lymph nodes
1860Brain tumor
1944Breast cancer
1993Esophagus cancer
No data
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No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of EEF1D mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of EEF1D mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of EEF1D mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of EEF1D mRNAaffects expression 16483693
D001280 Atrazine [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of EEF1D mRNAaffects cotreatment|increases expression 16532367
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of EEF1D mRNAdecreases expression 20498004
D016572 Cyclosporine Cyclosporine results in increased expression of EEF1D mRNAincreases expression 20106945
D004237 Diuron [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of EEF1D mRNAaffects cotreatment|increases expression 16532367
D018684 Glycine Agents Glycine Agents results in decreased expression of EEF1D mRNAdecreases expression 16532367
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of EEF1D mRNAaffects cotreatment|increases expression 17183730
C028904 isoproturon [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of EEF1D mRNAaffects cotreatment|increases expression 16532367
D012643 Selenium Selenium results in increased expression of EEF1D mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of EEF1D mRNAincreases expression 18796159
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of EEF1D mRNAaffects cotreatment|increases expression 17183730
D014810 Vitamin E Vitamin E results in increased expression of EEF1D mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.4815322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.488875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9619490988
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9920464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.676695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4316835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.2711874814
MESH:D000550 Amblyopia Valproic Acid 5.3017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.5917497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8515238991 18177632 18558336 18396377 20603192 18940202 17507914 17157402 19460635 16609825 18985861 17688650 19232924 18775368 18316065
MESH:D001714 Bipolar Disorder Valproic Acid 3.0920046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.0815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.088888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8920146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9716050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.5316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.5316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.533084413
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3816120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.646135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.6412371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Cyclosporine 2.9419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.118697196 16354765 15340226 12621046 15668235
MESH:D003092 Colitis Selenium 3.8217936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7915322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.7916575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.7919769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.0418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.0418551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.3821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.3821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.3812153990 16227642 12540782 11287661 19420014 11834606 14550746 16781746 10774834 15968718 15619225 19739265 10663392 11461765 12392966 18071297 11529661 16081117 17562736 17906064 19923254 12705907 19164858 16177239 16393943 11743745 17522070 11739529 16485898 16109766 12958197 19085960 12594235 18713872 19370779 14725611 11421492 19416960 2444490 10915739 14986274
MESH:D056486 Drug-Induced Liver Injury Selenium 15.3815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.3820420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 15.381733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004421 Dystonia Valproic Acid 4.081851702
MESH:C538011 Eales disease Vitamin E 4.779068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9616714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.193659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.9816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9518234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.617562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.347750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.113659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Cyclosporine 7.8519224547
MESH:D005234 Fatty Liver Valproic Acid 7.8519224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005315 Fetal Diseases Valproic Acid 4.9516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.178888407 18558336
MESH:D005355 Fibrosis Cyclosporine 8.6212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6220067830
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.1920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.1911294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.1916080930
MESH:D006333 Heart Failure Selenium 3.0917162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9315340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7116490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.0314716179
MESH:D006849 Hydrocephalus Valproic Acid 4.9217688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1115340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006973 Hypertension Cyclosporine 4.9810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9818670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.6716612254
MESH:D007248 Infertility, Male Atrazine 3.7312948887
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8712200463 12878042
MESH:D007251 Influenza, Human Selenium 11.1716624496
MESH:D007251 Influenza, Human Vitamin E 11.1716624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Acetaminophen 10.1012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.108314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 10.1012488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9116518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.5116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.5116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.5112371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1517596541 16294345
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3512878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3516169303
MESH:D008107 Liver Diseases Acetaminophen 1.6312587719 16611625 11587558 12969438 16610002 19014921 19460945 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.417678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.4121137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.796135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.7912151625
MESH:D008171 Lung Diseases Vitamin E 3.1916863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3217228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3820135361 20869020 20464547 20064080 18816296 17053015 6695378 18520028 18569708
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3819555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 3.3811062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7815318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008654 Mesothelioma Atrazine 6.501916698
MESH:D008654 Mesothelioma Selenium 6.5015107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2118765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2116381670
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.068888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.5218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.527678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1811141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2514600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.148888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.9816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9816049721
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010300 Parkinson Disease Atrazine 3.2817218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010954 Plasmacytoma Selenium 4.9515087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6311896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.6320603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1817292933
MESH:D011471 Prostatic Neoplasms Vitamin E 3.1815084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.6011422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D012135 Respiratory Sounds Atrazine 4.5611874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2119155313
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 9.9318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.9318551238
MESH:D012640 Seizures Valproic Acid 9.9311044598 17978042 1511512 15475178 3137016 11738929 14763951 16876388
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5110029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5116192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8019490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6012833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Vitamin E 3.5416517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.3017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.573119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.3316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.3316049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.3317053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.688888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.1610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.1610091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:17015 Metabolism of proteins
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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