AutismKB 2.0

Annotation Detail for EFNA5


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Basic Information Top
Gene Symbol:EFNA5 ( AF1,EFL5,EPLG7,GLC1M,LERK7,RAGS )
Gene Full Name: ephrin-A5
Band: 5q21.3
Quick LinksEntrez ID:1946; OMIM: 601535; Uniprot ID:EFNA5_HUMAN; ENSEMBL ID: ENSG00000184349; HGNC ID: 3225
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
No data
Pathway IDPathway Name
200121EPHA forward signaling
200040EphrinA-EPHA pathway
200041EPHB forward signaling
200048Ephrin A reverse signaling
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
hippocampal atrophy
Desease Name
Hippocampal atrophy
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of EFNA5 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of EFNA5 mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EFNA5 mRNAdecreases expression 20018196
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of EFNA5 mRNAaffects expression 12734012
D005665 Furosemide Furosemide results in increased expression of EFNA5 mRNAincreases expression 16526316
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of EFNA5 mRNAdecreases expression 20713471
C006253 pirinixic acid pirinixic acid results in increased expression of EFNA5 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000236 Adenoma Methylcholanthrene 3.666695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D050197 Atherosclerosis Methylcholanthrene 3.6211922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.8417474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2016011737 15721981 16124888 18705752 16050911 15700767 16097048 16227642 10355542 15673190 3786805 16192424
MESH:D002277 Carcinoma Methylcholanthrene 4.2210545420
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.963084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.9618788625
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6220889678
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 7.6216192471
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9911739529 19923254 12540782 11834606 18071297 16081117 11461765 12958197 14550746 11421492 11743745 16177239 19416960 11287661 12705907 10915739 11529661 17522070 12392966 16227642 16393943 15968718 19370779 15619225 17562736 16781746 18713872 14725611 10663392 17906064 16485898 19739265 19164858 19085960 12153990 16109766 10774834 14986274 12594235 2444490 19420014
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.999327722 7179309 10915739 11566570 21278145 15027814 2869522 3732212 4309450 6623471 16227642 15998439 17522070 7120509 19085960 19336974 10092053 7440962 16177239 3786805 6884620 15968718
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004417 Dyspnea Furosemide 5.4616935035
MESH:D004487 Edema Furosemide 8.2311834646
MESH:D004487 Edema pirinixic acid 8.2312083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.7815959796 17595544 19224547 16239168 61145 16045604 12631006 12795759
MESH:D005234 Fatty Liver pirinixic acid 8.7819236843 20131406
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.4010962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 3.8718705752
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D034381 Hearing Loss Furosemide 5.1117868369
MESH:D006333 Heart Failure Furosemide 7.9116011733 12660669 16845234
MESH:D006333 Heart Failure pirinixic acid 7.9120558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.4119772884 16221962 19176532 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006934 Hypercalcemia Furosemide 5.4017652376
MESH:D053565 Hypercalciuria Furosemide 6.1217652376
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 6.4015086907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.7016612254
MESH:C537153 Hypomagnesemia primary Furosemide 6.1211041285
MESH:D007019 Hypoproteinemia Furosemide 6.4016096441
MESH:D007022 Hypotension Furosemide 4.9711041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.9415811171
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007674 Kidney Diseases Acetaminophen 6.8715629191 12587719
MESH:D007674 Kidney Diseases Furosemide 6.8711041285
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9616943688 16221502 11408273 17174718 17334410 11903743 21278145 17157831 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.4012898905 17708605 17557913 12445418 12667390 17869086 18376398 17481882 17714472 15673190 18429990 15370692 18251166 14512876 18395914 17823541 12546737 12666154 18156304 14716496 15876570 18210741 17640975 16248980 12445421 15730626 18412020 15925388 16027843 18472332 17525996 14620537 18418968 18006644 15362042 12389079 15057751 16136751 15650968 17698563 18317297 15818738 18481824 17761835 17631135 12632514 16638106 18277467 16033810 14748882 17944888 18054572 18279442 15338365 11481614 12649538 14724832 17805973 20821823 18472094 16116963 16015684 15893842 18705752 12586293 18420326 14716833 15123356 18263696 16011737 15052691 18187930 10355542 16192424 15959796 18339082 12958196 17922224 15931870 12609069 12632512 13678700 15996030 17721639 18166357 17976157 12741479 18395095 17565644 17766677 18205269 17900296 16097048
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4015474484
MESH:D008107 Liver Diseases Acetaminophen 4.1212587719 19784758 16610002 12969438 11587558 16611625 19014921 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1216964402 17285989 15830285 16246199 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.4416871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.4414706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.7619294768
MESH:D008113 Liver Neoplasms pirinixic acid 4.7620007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.8015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 6.801399818 598648
MESH:D008175 Lung Neoplasms Methylcholanthrene 2.416695378 16271038 20512841 1399818 21163286 16337739 17909032 9230183 11893704 20970405 10545420 15390079 7750092
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009397 Nephrocalcinosis Furosemide 6.4015086907
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D053206 Nocturnal Enuresis Furosemide 6.4017945291
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D011141 Polyuria Furosemide 6.1217945291
MESH:D015427 Reperfusion Injury marker/mechanism 16526316
MESH:D015427 Reperfusion Injury Furosemide 7.2516526316
MESH:D015427 Reperfusion Injury pirinixic acid 7.2519058328
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.9716096441 12394941 15912074
MESH:D013274 Stomach Neoplasms Furosemide 2.8617052386
MESH:D014581 Urticaria Acetaminophen 3.3310982225
Pathway ID Pathway Name
KEGG:04360 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27660
    • No data
    No data
    Releated drug ID Related drug Name
    PA452229antidepressants
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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