AutismKB 2.0

Annotation Detail for CELSR3


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Basic Information Top
Gene Symbol:CELSR3 ( CDHF11,EGFL1,FMI1,HFMI1,MEGF2,RESDA1 )
Gene Full Name: cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
Band: 3p21.31
Quick LinksEntrez ID:1951; OMIM: 604264; Uniprot ID:CELR3_HUMAN; ENSEMBL ID: ENSG00000008300; HGNC ID: 3230
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CELSR3 mRNAaffects expression 16483693
D003907 Dexamethasone Dexamethasone results in decreased expression of CELSR3 mRNAdecreases expression 12782123
D004642 Emodin Emodin results in decreased expression of CELSR3 mRNAdecreases expression 16045814
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CELSR3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CELSR3 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in increased expression of CELSR3 mRNAincreases expression 18035473
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CELSR3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CELSR3 mRNAincreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3111752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Dexamethasone 7.9717659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.9715885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 18850075 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1017333356 16919318 17681005 16105132 17110522 15861022 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115668235 12621046 15340226 16354765 8697196
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5315824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.6917728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6915322242 20055451 10048152
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.8112438553
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003967 Diarrhea Dexamethasone 4.077237001
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004485 Eczema Dexamethasone 4.8412438553
MESH:D004487 Edema Dexamethasone 7.9719703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.9712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.1415345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Emodin 10.5219474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.5220067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3116120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.167520565
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5716959395 15340226 18606429 8697196 16354765
MESH:D006973 Hypertension Dexamethasone 5.5817042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5818670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Dexamethasone 9.248960868 11099482
MESH:D007249 Inflammation Flavonoids 9.2417296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.2412878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 5.3517077332
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 3.8516718785
MESH:D008106 Liver Cirrhosis, Experimental Emodin 3.8515288473
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.8512878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008175 Lung Neoplasms Dexamethasone 2.5115824018 11195469
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5119555203 11884234
MESH:D009101 Multiple Myeloma Dexamethasone 3.7215867202 16118317 15744524
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.709809623
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.7021297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511118676 11896295 11222880 11399792
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.3711700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D013272 Stomach Diseases Dexamethasone 4.7815472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.8115138204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D014605 Uveitis Dexamethasone 5.341336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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