AutismKB 2.0

Annotation Detail for ARID2


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Basic Information Top
Gene Symbol:ARID2 ( BAF200,DKFZp686G052,DKFZp779P0222,FLJ30619,KIAA1557,p200 )
Gene Full Name: AT rich interactive domain 2 (ARID, RFX-like)
Band: 12q12
Quick LinksEntrez ID:196528; OMIM: 609539; Uniprot ID:ARID2_HUMAN; ENSEMBL ID: ENSG00000189079; HGNC ID: 18037
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
hippocampal atrophy
Desease Name
Hippocampal atrophy
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ARID2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ARID2 mRNAaffects expression 21346803
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ARID2 mRNAdecreases expression 19150397
D004041 Dietary Fats Dietary Fats results in increased expression of ARID2 mRNAincreases expression 18042831
C051890 irinotecan irinotecan analog results in decreased expression of ARID2 mRNAdecreases expression 18927307
C041786 palm oil palm oil results in increased expression of ARID2 mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ARID2 mRNAaffects binding|increases activity|increases expression 19710929
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in increased expression of ARID2 mRNAaffects cotreatment|increases expression 19465110
C025643 vinclozolin vinclozolin affects the expression of ARID2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 15322242 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001008 Anxiety Disorders vinclozolin 3.8019015723
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9720435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0416705839
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.106135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1020889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1816354765 15340226 8697196 15668235 12621046
MESH:D003110 Colonic Neoplasms irinotecan 2.6217725105 17287894
MESH:D015179 Colorectal Neoplasms irinotecan 2.3616303861 18259882 17454858 17159606 18509181 16391804 15273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.5814966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Dietary Fats 8.3918296743 19551842 17967931 19004024
MESH:D005234 Fatty Liver pirinixic acid 8.3919236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Dietary Fats 9.5018296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5020067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6216417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly pirinixic acid 9.1419176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1412621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 16959395 16354765 18606429 15340226
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007248 Infertility, Male vinclozolin 3.1716467254
MESH:D007249 Inflammation Dietary Fats 5.2420412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2412200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.6718457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.6716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.9416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.9416705839
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0216417039
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9818296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1912878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.727678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.7220007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.146135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1412151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D052016 Mucositis irinotecan 5.2917159606
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.327678174 18551238
MESH:D009362 Neoplasm Metastasis irinotecan 3.2418259882
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009447 Neuroblastoma irinotecan 3.578761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.018761367
MESH:D009765 Obesity Dietary Fats 4.5818674790 21332399 19632207 11836018 18457598 20518802 16723640 17217161 20132043
MESH:D009765 Obesity pirinixic acid 4.5820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.5416049721
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4611222880 11896295 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.4619015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.2218220299
MESH:D011472 Prostatitis vinclozolin 5.2218629315
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2416049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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