AutismKB 2.0

Annotation Detail for ADCY4


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Basic Information Top
Gene Symbol:ADCY4 ( AC4 )
Gene Full Name: adenylate cyclase 4
Band: 14q12
Quick LinksEntrez ID:196883; OMIM: 600292; Uniprot ID:ADCY4_HUMAN; ENSEMBL ID: ENSG00000129467; HGNC ID: 235
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04020Calcium signaling pathway
hsa05414Dilated cardiomyopathy
hsa04540Gap junction
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa00230Purine metabolism
hsa04971Gastric acid secretion
hsa04114Oocyte meiosis
hsa04742Taste transduction
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Transmembrane transport of small molecules
Opioid Signalling
Integration of energy metabolism
Pathway IDPathway Name
200036LPA4-mediated signaling events
200004Endothelins
200011LPA receptor mediated events
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00019Endothelin signaling pathway
P05731GABA-B receptor II signaling
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ADCY4 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADCY4 mRNAaffects expression 16483693
D002220 Carbamazepine Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY4 protein]affects binding|decreases reaction|increases activity 19922557
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of ADCY4 mRNAaffects cotreatment|affects expression 18636392
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of ADCY4 mRNAincreases expression 17452286
D003976 Diazinon Diazinon results in increased expression of ADCY4 mRNAincreases expression 17452286
D004041 Dietary Fats Dietary Fats results in increased expression of ADCY4 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADCY4 mRNAaffects cotreatment|increases expression 17942748
D010126 Ozone Ozone results in decreased expression of ADCY4 mRNAdecreases expression 12763052
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of ADCY4 mRNAaffects cotreatment|affects expression 18636392
C041786 palm oil palm oil results in increased expression of ADCY4 mRNAincreases expression 18042831
D010852 Picrotoxin Picrotoxin results in increased expression of ADCY4 mRNAincreases expression 15170462
C071262 SK&F 82958 Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY4 protein]affects binding|decreases reaction|increases activity 19922557
C071262 SK&F 82958 [SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY4 proteinaffects binding|increases activity 19922557
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ADCY4 mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADCY4 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 9.098986270
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.0911752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury Chlorine 4.4120601635
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 9.5716611668 17119214 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.5716487989
MESH:D000544 Alzheimer Disease Ozone 2.4515513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001161 Arteriosclerosis Dietary Fats 10.2615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5715570426
MESH:D001249 Asthma Ozone 2.6616373670 17854713
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001714 Bipolar Disorder Carbamazepine 4.1717594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9820435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7415516495 14754758 18315731 17626835 19059883 18417511 16777450
MESH:D002100 Cachexia Ozone 4.8616183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.383084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9315861022 17110522 17333356 11677210 16919318 17681005 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 8697196 12621046 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Carbamazepine 2.889014606
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8810048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.5511748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.4520216337 16538176 15057820 16538175
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4216081117 17562736 10774834 15619225 12392966 19370779 16227642 19923254 16109766 2444490 14986274 16393943 19085960 18713872 15968718 12594235 19420014 11739529 11834606 19164858 12958197 11743745 16177239 16485898 11287661 19739265 14550746 12705907 18071297 19416960 14725611 11421492 11529661 12540782 12153990 17906064 17522070 16781746 10663392 11461765 10915739
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 6.4217465707
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Carbamazepine 8.6020216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.6011462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5118367378
MESH:D004417 Dyspnea Chlorine 11.1320016425
MESH:D004417 Dyspnea Diazinon 11.1316487989
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 9.7017654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7012538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.3519915237 16538176 20485159 16415921 18855540
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 5.3117275665
MESH:D004828 Epilepsies, Partial Carbamazepine 5.1117116037 16628512 15008574
MESH:D004827 Epilepsy Carbamazepine 4.03821787 19620853 17465707 9014606 18234410 19439326 7988514 20417680 19700373 17178248
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 5.467750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 5.2415276670 3659116
MESH:D004916 Erythromelalgia Carbamazepine 5.8419549232
MESH:D005076 Exanthema Carbamazepine 5.5820485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Dietary Fats 7.9918296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.9915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Dietary Fats 8.9718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9720067830
MESH:D005739 Gas Poisoning Chlorine 5.1420016425
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis Diazinon 4.6716487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0016120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 18606429 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6721332399
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.8010459572
MESH:D006949 Hyperlipidemias Dietary Fats 3.7021332399
MESH:D006965 Hyperplasia Carbamazepine 5.3118773962
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Diazinon 7.1312948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1317937319
MESH:D007249 Inflammation Dietary Fats 5.0520412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0512878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 3.1518457598 11836018
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2412587719 15629191
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9218296743
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 4.3319014921 16611625 19460945 11587558 19784758 12587719 12969438 16610002
MESH:D008107 Liver Diseases Chlorpyrifos 4.3315991261
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1512151625
MESH:D008171 Lung Diseases Ozone 3.4319066396 8266340
MESH:D055370 Lung Injury Ozone 3.9520417186
MESH:D008175 Lung Neoplasms Ozone 2.407614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4011884234 19555203
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5916628512
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008607 Mental Retardation Carbamazepine 3.759014606
MESH:D008679 Metaplasia Ozone 5.2410496685
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009224 Myotonia Congenita Carbamazepine 5.5820399394
MESH:D009421 Nervous System Malformations Carbamazepine 10.2516990009
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.2514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.2215081274
MESH:D009765 Obesity Dietary Fats 2.3017217161 18674790 11836018 19632207 18457598 21332399 20132043 16723640 20518802
MESH:D010018 Osteomalacia Carbamazepine 5.5817016548
MESH:D010146 Pain Acetaminophen 7.2316870215
MESH:D010146 Pain Carbamazepine 7.2315215642
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010267 Parapsoriasis Carbamazepine 5.8016538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 6.0417679678 17145499
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010538 Peritonitis Ozone 4.2316369182
MESH:D011014 Pneumonia Ozone 4.5118007984 18929643 18381685
MESH:D011041 Poisoning Diazinon 4.4417603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011248 Pregnancy Complications Carbamazepine 5.269014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 10.259014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2511222880 11896295 11118676 11399792
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D019310 Pseudolymphoma Carbamazepine 5.7312752131 9591791
MESH:D012120 Respiration Disorders Chlorine 5.3518579056
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.7416611668 17119214 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.0317119214 16611668
MESH:D012640 Seizures Carbamazepine 7.0519414003 15946322 16938433 9844417 16180713 9046859 16876388
MESH:D012640 Seizures Picrotoxin 7.058954991 8635557
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.226418539
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D012893 Sleep Disorders Carbamazepine 5.2419414003
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.3118855540 20485159 16538176 16415921 15057820 19694795 19915237
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D014570 Urologic Diseases Diazinon 5.4116487989
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D015430 Weight Gain Dietary Fats 3.8116723640
Pathway ID Pathway Name
KEGG:04976 Bile secretion
KEGG:04020 Calcium signaling pathway
KEGG:04062 Chemokine signaling pathway
KEGG:05414 Dilated cardiomyopathy
KEGG:04540 Gap junction
KEGG:04971 Gastric acid secretion
KEGG:04724 Glutamatergic synapse
KEGG:04912 GnRH signaling pathway
REACT:1505 Integration of energy metabolism
KEGG:04916 Melanogenesis
KEGG:04114 Oocyte meiosis
REACT:15295 Opioid Signalling
KEGG:04972 Pancreatic secretion
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:00230 Purine metabolism
KEGG:04970 Salivary secretion
REACT:14797 Signaling by GPCR
REACT:11061 Signalling by NGF
REACT:13685 Synaptic Transmission
KEGG:04742 Taste transduction
REACT:15518 Transmembrane transport of small molecules
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24562
    • No data
    No data
    Releated drug ID Related drug Name
    PA165290926fluticasone/salmeterol
    PA451300salmeterol
    PA164749238exenatide
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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