AutismKB 2.0

Annotation Detail for MLKL


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Basic Information Top
Gene Symbol:MLKL ( FLJ34389 )
Gene Full Name: mixed lineage kinase domain-like
Band: 16q22.3
Quick LinksEntrez ID:197259; OMIM: NA; Uniprot ID:MLKL_HUMAN; ENSEMBL ID: ENSG00000168404; HGNC ID: 26617
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MLKL mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in increased expression of MLKL mRNAincreases expression 20106945
D019833 Genistein Genistein results in decreased expression of MLKL mRNAdecreases expression 18847459
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MLKL mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of MLKL mRNAincreases expression 19482888
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 4.076195326
MESH:D000230 Adenocarcinoma Genistein 2.5511473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.6017620307
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Genistein 2.4817200150 16873071 16541309
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.853084413
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.8516924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.8517173139 1701930 6705139 20935162 20007298
MESH:D002318 Cardiovascular Diseases Genistein 3.5616332659
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7912371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.814080065
MESH:D002779 Cholestasis Cyclosporine 3.2119486331
MESH:D003110 Colonic Neoplasms Genistein 2.3317182828
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5616647724
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6712392966 16227642 11743745 14986274 19420014 16781746 11739529 15968718 14550746 19370779 18713872 12958197 11529661 19085960 15619225 17522070 19164858 11461765 17906064 18071297 12594235 16485898 12540782 11287661 12153990 11421492 10774834 19739265 10663392 11834606 2444490 14725611 19923254 19416960 17562736 16109766 16393943 10915739 16081117 12705907 16177239
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004421 Dystonia Phenobarbital 4.471851702
MESH:D004714 Endometrial Hyperplasia Genistein 5.2216402032
MESH:D016889 Endometrial Neoplasms Genistein 3.6011473722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.673659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.593922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.916401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.817750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.653659116
MESH:D005234 Fatty Liver Cyclosporine 3.2819224547
MESH:D005355 Fibrosis Cyclosporine 3.7012168785 12639820
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D005909 Glioblastoma Genistein 3.5016598420
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006529 Hepatomegaly Phenobarbital 4.0416109766
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D006973 Hypertension Cyclosporine 2.2110903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.4812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.488314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0812371664
MESH:D007938 Leukemia Genistein 3.1917468513 18980019
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0821047994
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0717823541
MESH:D008107 Liver Diseases Acetaminophen 4.2019014921 16610002 12969438 19784758 19460945 11587558 16611625 12587719
MESH:D008107 Liver Diseases Phenobarbital 4.2019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008113 Liver Neoplasms Phenobarbital 2.4219812893 15975961 19073162 19482888 21047994 8742319
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.922563599 1399818 6150874 17172636 18308698
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.1712929590 14578162
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D009203 Myocardial Infarction Genistein 2.9917141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.9717141266
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.1117484760
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6518481113 19348381
MESH:D009421 Nervous System Malformations Genistein 4.5416427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010018 Osteomalacia Phenobarbital 5.0017016548
MESH:D010024 Osteoporosis Genistein 3.4719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.5516169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6919005980
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.6016965848
MESH:D011230 Precancerous Conditions Cyclosporine 10.2212371664
MESH:D011230 Precancerous Conditions Phenobarbital 10.222563599
MESH:D011471 Prostatic Neoplasms Genistein 3.4015378649 16925846 15256057
MESH:D019310 Pseudolymphoma Phenobarbital 5.2212752131
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D012640 Seizures Phenobarbital 2.953137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.456407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.361399818
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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