AutismKB 2.0

Annotation Detail for EIF4B


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Basic Information Top
Gene Symbol:EIF4B ( EIF-4B,PRO1843 )
Gene Full Name: eukaryotic translation initiation factor 4B
Band: 12q13.13
Quick LinksEntrez ID:1975; OMIM: 603928; Uniprot ID:IF4B_HUMAN; ENSEMBL ID: ENSG00000063046; HGNC ID: 3285
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04150mTOR signaling pathway
Pathway IDPathway Name
Metabolism of proteins
Metabolism of RNA
Signaling by Insulin receptor
Gene Expression
3' -UTR-mediated translational regulation
Pathway IDPathway Name
200080mTOR signaling pathway
No data
Pathway IDPathway Name
500993S6K1 signalling
500901Cap-dependent Translation Initiation
500864Translation initiation complex formation
500944Ribosomal scanning and start codon recognition
500855Deadenylation of mRNA
500880Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 4
500526L13a-mediated translational silencing of Ceruloplasmin expression
500970GTP hydrolysis and joining of the 60S ribosomal subunit
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of EIF4B mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of EIF4B mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of EIF4B mRNAdecreases expression 12958071
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of EIF4B mRNAincreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of EIF4B mRNAincreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of EIF4B mRNAincreases expression 19150397
C099555 CD 437 CD 437 results in decreased expression of EIF4B mRNAdecreases expression 12958071
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF4B mRNAaffects cotreatment|increases expression 17942748
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of EIF4B mRNAaffects cotreatment|increases expression 17183730
C097613 imatinib imatinib results in decreased expression of EIF4B mRNAdecreases expression 19208803
C421324 pateamine A pateamine A affects the localization of EIF4B proteinaffects localization 16951406
C006253 pirinixic acid pirinixic acid results in decreased expression of EIF4B mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased phosphorylation of EIF4B proteinincreases phosphorylation 18602970
C017947 sodium arsenite sodium arsenite affects the localization of EIF4B proteinaffects localization 16951406
D018038 Sodium Selenite Sodium Selenite results in increased expression of EIF4B mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF4B mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of EIF4B proteindecreases expression 16548065
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of EIF4B mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.3811752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.388875741
MESH:D000015 Abnormalities, Multiple imatinib 10.5418322153
MESH:D000015 Abnormalities, Multiple Valproic Acid 10.5419490988
MESH:D000022 Abortion, Spontaneous imatinib 6.2418322153
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1820127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1814692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.603712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.606695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.9716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9316712894 17306315
MESH:D000550 Amblyopia Valproic Acid 5.2617688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.5717497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001321 Autistic Disorder Valproic Acid 2.0018316065 15238991 17507914 20603192 18940202 18985861 16609825 18558336 19460635 18177632 18775368 19232924 18396377 17688650 17157402
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.051440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.0817594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.0315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.038888407
MESH:D001859 Bone Neoplasms imatinib 5.3315867366
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9920146248 17474063
MESH:D001943 Breast Neoplasms imatinib 1.9917614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.5816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.5816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.583581430 7296757
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.5815276417 17306315 16507464
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.687296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6020419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.6018572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.056135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.057505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.0520889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 16.0520056578 19524636
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7120734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.399022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.3916105132 15861022 16919318 17681005 11677210 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 13.3919176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1015340226 8697196 12621046 15668235 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0614669216 17141729
MESH:D019465 Craniofacial Abnormalities imatinib 3.9518322153
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.9517688650 8888407 16575769
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.9418551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.822524372 14531868 8970840 18759878 11298694 8156756 11906362 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.502952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7816285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.2921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.2918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.2918289764 9328219 7440962 9022650 18692083 6679447 8291058 1440618 18648102 9653073 6482804 11289319 16192314
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 15.2915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.2920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 15.291733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004421 Dystonia Valproic Acid 4.061851702
MESH:D004487 Edema imatinib 11.5919703484
MESH:D004487 Edema pirinixic acid 11.5912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.5911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9315322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.173659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.9516628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9418234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.597562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.317750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.083659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.193581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.1916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.0915345470
MESH:D005234 Fatty Liver pirinixic acid 13.0920131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 13.0919224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005315 Fetal Diseases Valproic Acid 4.9216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.148888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.056705139
MESH:D018222 Fibromatosis, Aggressive imatinib 5.6717453242
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9620067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7016452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.047505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4510048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.526705139
MESH:D006529 Hepatomegaly pirinixic acid 8.3116221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.3115340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.1612676792
MESH:D006849 Hydrocephalus Valproic Acid 4.8917688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0815340226 18606429 8697196 16354765 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9118850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.6416612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.6517937319
MESH:D007248 Infertility, Male sodium arsenite 6.6512646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8612200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 7.3216306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.3214714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.058074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007674 Kidney Diseases sodium arsenite 2.8020008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.4116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.4116705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.416582329
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive imatinib 4.7715748426 17301526 19208803 15107311
MESH:D007951 Leukemia, Myeloid imatinib 5.1017236224
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1517596541 16294345
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental imatinib 3.5816596278
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5812878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.247678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.2420195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 14.2415890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 14.2416712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.2416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.782876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.78598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7812151625
MESH:D008171 Lung Diseases sodium arsenite 3.1719095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2917228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3620464547 18520028 17053015 20135361 20869020 18816296 18569708 20064080 6695378
MESH:D008175 Lung Neoplasms sodium arsenite 3.3616712894 19931552 17306315 15276417 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3611884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0614737004
MESH:D008545 Melanoma sodium arsenite 2.0319082730 16487513
MESH:D008881 Migraine Disorders Valproic Acid 3.1918765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.038888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1517596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.4118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.417678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.243581430
MESH:D009362 Neoplasm Metastasis imatinib 6.2415867366
MESH:D009369 Neoplasms Benzo(a)pyrene 8.2111141357
MESH:D009369 Neoplasms pirinixic acid 8.2117405874
MESH:D009369 Neoplasms sodium arsenite 8.2111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6820056578
MESH:D009376 Neoplasms, Hormone-Dependent imatinib 5.4917614352
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2214600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.156679447
MESH:D009436 Neural Tube Defects sodium arsenite 12.1512854658
MESH:D009436 Neural Tube Defects Valproic Acid 12.158888407 16359493
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.0912819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.0916049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.094026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.053988306
MESH:D010014 Osteolysis imatinib 5.7615867366
MESH:D010051 Ovarian Neoplasms CD 437 5.2417474084
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.2417306315 15276417
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.507296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.506228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma imatinib 4.4812476293
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5311399792 11222880 11118676 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.5320603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5717292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5716039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5718760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.5711422049 12752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.383692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.1819155313
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 9.8318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.8318551238
MESH:D012640 Seizures Valproic Acid 9.831511512 17978042 14763951 16876388 3137016 11738929 15475178 11044598
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.4110029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 9.4118572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.4116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D016135 Spinal Dysraphism sodium arsenite 9.5512854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.5519490988
MESH:D013226 Status Epilepticus Valproic Acid 4.5712833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.862093021 20155912
MESH:D013274 Stomach Neoplasms imatinib 2.8615786421
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.667505956 6582329 3712494 1399818 6587162
MESH:D013964 Thyroid Neoplasms imatinib 7.6616940797
MESH:D014178 Translocation, Genetic Valproic Acid 5.2617262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.543119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 19.9116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 19.9116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 19.918074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 19.9117053015
MESH:D001749 Urinary Bladder Neoplasms CD 437 19.9116720286
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 19.9116712894 16452187 17306315 11723127
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.668888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.0610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.0610091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7711813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014652 Vascular Diseases sodium arsenite 4.4417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:71 Gene Expression
REACT:17015 Metabolism of proteins
REACT:21257 Metabolism of RNA
KEGG:04150 mTOR signaling pathway
KEGG:03013 RNA transport
REACT:498 Signaling by Insulin receptor
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27713
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA451365sirolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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