AutismKB 2.0

Annotation Detail for EIF4E


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Basic Information Top
Gene Symbol:EIF4E ( CBP,EIF4E1,EIF4EL1,EIF4F,MGC111573 )
Gene Full Name: eukaryotic translation initiation factor 4E
Band: 4q23
Quick LinksEntrez ID:1977; OMIM: 133440; Uniprot ID:IF4E_HUMAN; ENSEMBL ID: ENSG00000151247; HGNC ID: 3287
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa04150mTOR signaling pathway
Pathway IDPathway Name
Metabolism of proteins
Metabolism of RNA
Signaling by Insulin receptor
mRNA Processing
Gene Expression
3' -UTR-mediated translational regulation
Pathway IDPathway Name
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200154Signaling mediated by p38-alpha and p38-beta
200080mTOR signaling pathway
200045Validated targets of C-MYC transcriptional activation
No data
Pathway IDPathway Name
500901Cap-dependent Translation Initiation
500899Transport of the SLBP Dependant Mature mRNA
500855Deadenylation of mRNA
500880Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 4
500928Transport of Mature mRNA derived from an Intron-Containing Transcript
500965Release of eIF4E
500657Transport of Mature Transcript to Cytoplasm
500862Transport of Mature mRNA Derived from an Intronless Transcript
500970GTP hydrolysis and joining of the 60S ribosomal subunit
500879Transport of the SLBP independent Mature mRNA
500658Transport of Mature mRNAs Derived from Intronless Transcripts
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1904Diabetes mellitus
1934Cancer
2011Leukoencephalopathy
2118Adenovirus infection
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of EIF4E mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of EIF4E mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of EIF4E mRNAdecreases expression 18648102
D000638 Amiodarone Amiodarone promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]affects binding|increases reaction 19771169
D000643 Ammonium Chloride Ammonium Chloride affects the expression of EIF4E mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide affects the expression of EIF4E mRNAaffects expression 20458559
C006632 arsenic trioxide [arsenic trioxide results in increased phosphorylation of and results in increased activity of MKNK1 protein] which results in increased phosphorylation of EIF4E proteinincreases activity|increases phosphorylation 18299328
C006632 arsenic trioxide CGP 57380 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of EIF4E protein]decreases reaction|increases activity|increases phosphorylation 18299328
C006632 arsenic trioxide CGP 57380 inhibits the reaction [[arsenic trioxide results in increased phosphorylation of and results in increased activity of MKNK1 protein] which results in increased phosphorylation of EIF4E protein]decreases reaction|increases activity|increases phosphorylation 18299328
C006632 arsenic trioxide MAPK14 protein promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of EIF4E protein]increases activity|increases phosphorylation|increases reaction 18299328
C006632 arsenic trioxide MKNK1 protein promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of EIF4E protein]increases activity|increases phosphorylation|increases reaction 18299328
C006632 arsenic trioxide MKNK2 protein promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of EIF4E protein]increases activity|increases phosphorylation|increases reaction 18299328
C006632 arsenic trioxide U 0126 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of EIF4E protein]decreases reaction|increases activity|increases phosphorylation 18299328
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of EIF4E mRNAincreases expression 20127859
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EIF4E mRNAdecreases expression 20382639
C466997 CGP 57380 CGP 57380 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of EIF4E protein]decreases reaction|increases activity|increases phosphorylation 18299328
C466997 CGP 57380 CGP 57380 inhibits the reaction [[arsenic trioxide results in increased phosphorylation of and results in increased activity of MKNK1 protein] which results in increased phosphorylation of EIF4E protein]decreases reaction|increases activity|increases phosphorylation 18299328
C466997 CGP 57380 CGP 57380 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF4E protein]decreases reaction|increases phosphorylation 16431125
18032482
C466997 CGP 57380 CGP 57380 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]decreases reaction|increases phosphorylation 15757502
C007262 deoxynivalenol deoxynivalenol results in decreased phosphorylation of EIF4E proteindecreases phosphorylation 16099139
D004040 Dietary Carbohydrates Dietary Carbohydrates results in increased expression of EIF4E mRNAincreases expression 17490981
D004958 Estradiol Estradiol results in decreased phosphorylation of EIF4E proteindecreases phosphorylation 16033851
D004958 Estradiol everolimus inhibits the reaction [Estradiol results in decreased phosphorylation of EIF4E protein]decreases phosphorylation|decreases reaction 16033851
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of EIF4E mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of EIF4E mRNAincreases expression 16174780
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF4E mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of EIF4E mRNAincreases expression 16174780
D005031 Ethylenethiourea Ethylenethiourea results in increased expression of EIF4E mRNAincreases expression 18801409
C107135 everolimus everolimus inhibits the reaction [Estradiol results in decreased phosphorylation of EIF4E protein]decreases phosphorylation|decreases reaction 16033851
C107135 everolimus everolimus results in increased phosphorylation of EIF4E proteinincreases phosphorylation 16033851
D005419 Flavonoids Flavonoids results in increased expression of EIF4E mRNAincreases expression 18035473
D005472 Fluorouracil Fluorouracil results in increased expression of EIF4E mRNAincreases expression 16584549
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of EIF4E mRNA]affects reaction|decreases expression 15016801
D005480 Flurbiprofen Flurbiprofen results in increased phosphorylation of EIF4E proteinincreases phosphorylation 18056468
D005480 Flurbiprofen MAPK14 protein promotes the reaction [Flurbiprofen results in increased phosphorylation of EIF4E protein]increases phosphorylation|increases reaction 18056468
D006820 Hyaluronic Acid Hyaluronic Acid results in increased phosphorylation of EIF4E proteinincreases phosphorylation 16864594
D007052 Ibuprofen Ibuprofen results in increased phosphorylation of EIF4E proteinincreases phosphorylation 18056468
D007052 Ibuprofen MAPK14 protein promotes the reaction [Ibuprofen results in increased phosphorylation of EIF4E protein]increases phosphorylation|increases reaction 18056468
C097613 imatinib imatinib results in decreased expression of EIF4E mRNAdecreases expression 19208803
C097613 imatinib imatinib results in decreased expression of EIF4E proteindecreases expression 19208803
C011890 kojic acid kojic acid results in decreased expression of EIF4E mRNAdecreases expression 16595896
D008070 Lipopolysaccharides CGP 57380 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF4E protein]decreases reaction|increases phosphorylation 18032482
16431125
D008070 Lipopolysaccharides Lipopolysaccharides results in increased phosphorylation of EIF4E proteinincreases phosphorylation 16431125
D008070 Lipopolysaccharides [SB 203580 co-treated with U 0126] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF4E protein]affects cotreatment|decreases reaction|increases phosphorylation 16431125
D009534 Niclosamide Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]affects binding|increases reaction 19771169
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of EIF4E mRNAincreases expression 17616710
C055122 orlistat orlistat results in increased phosphorylation of EIF4E proteinincreases phosphorylation 18796435
C421324 pateamine A pateamine A affects the localization of EIF4E proteinaffects localization 16951406
C494474 perchlorate perchlorate results in increased expression of EIF4E mRNAincreases expression 18801409
D010480 Perhexiline Perhexiline promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]affects binding|increases reaction 19771169
D010634 Phenobarbital Phenobarbital results in increased expression of EIF4E mRNAincreases expression 19363144
D010656 Phenylephrine CGP 57380 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]decreases reaction|increases phosphorylation 15757502
D010656 Phenylephrine Phenylephrine results in increased phosphorylation of EIF4E proteinincreases phosphorylation 15757502
D010656 Phenylephrine Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]decreases reaction|increases phosphorylation 15757502
D010656 Phenylephrine U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]decreases reaction|increases phosphorylation 15757502
C045950 propiconazole propiconazole results in increased expression of EIF4E mRNAincreases expression 19363144
D012314 RNA Cap Analogs RNA Cap Analogs binds to EIF4E proteinaffects binding 16248001
C085746 rottlerin rottlerin promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]affects binding|increases reaction 19771169
C093642 SB 203580 [SB 203580 co-treated with U 0126] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF4E protein]affects cotreatment|decreases reaction|increases phosphorylation 16431125
D020123 Sirolimus Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]decreases reaction|increases phosphorylation 15757502
C017947 sodium arsenite EIF4E protein results in decreased susceptibility to sodium arsenitedecreases response to substance 16283521
C017947 sodium arsenite sodium arsenite affects the localization of EIF4E proteinaffects localization 16951406
C017947 sodium arsenite sodium arsenite inhibits the reaction [RBM4 protein binds to EIF4E protein]affects binding|decreases reaction 17284590
C017947 sodium arsenite sodium arsenite results in increased expression of EIF4E mRNAincreases expression 12016162
C017947 sodium arsenite sodium arsenite results in increased ubiquitination of and results in decreased expression of EIF4E proteindecreases expression|increases ubiquitination 16283521
D013629 Tamoxifen Tamoxifen affects the expression of EIF4E mRNAaffects expression 17555576
C534735 tetraarsenic tetrasulfide tetraarsenic tetrasulfide results in decreased expression of EIF4E proteindecreases expression 19208803
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of EIF4E mRNAdecreases expression 15056799
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF4E mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of EIF4E mRNAincreases expression 17942748
D013792 Thalidomide Thalidomide results in decreased expression of EIF4E proteindecreases expression 18291259
D013876 Thiophenes Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of EIF4E mRNA]decreases expression|increases reaction 16140955
D014212 Tretinoin Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of EIF4E mRNA]decreases expression|increases reaction 16140955
D014212 Tretinoin Tretinoin results in decreased expression of EIF4E mRNAdecreases expression 16140955
C032910 triadimefon triadimefon results in increased expression of EIF4E mRNAincreases expression 19363144
D014415 Tunicamycin Tunicamycin results in increased expression of EIF4E mRNAincreases expression 17127020
C113580 U 0126 U 0126 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of EIF4E protein]decreases reaction|increases activity|increases phosphorylation 18299328
C113580 U 0126 [SB 203580 co-treated with U 0126] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF4E protein]affects cotreatment|decreases reaction|increases phosphorylation 16431125
C113580 U 0126 U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]decreases reaction|increases phosphorylation 15757502
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.0514745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.546195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.5415322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Thalidomide 11.548333272
MESH:D000015 Abnormalities, Multiple imatinib 4.8218322153
MESH:D000022 Abortion, Spontaneous imatinib 5.7218322153
MESH:D000138 Acidosis Ammonium Chloride 3.0718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4517505938
MESH:D000168 Acrocephalosyndactylia U 0126 5.0017694057
MESH:D058186 Acute Kidney Injury Ibuprofen 4.026375363
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.5918653653 11850527
MESH:D000230 Adenocarcinoma arsenic trioxide 18.5911798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 18.5920464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 18.5911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 18.5914692618
MESH:D000230 Adenocarcinoma Ethylenethiourea 18.597955072
MESH:D000230 Adenocarcinoma Fluorouracil 18.5917638652
MESH:D000230 Adenocarcinoma Ibuprofen 18.5910697514
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 5.613712494
MESH:D000236 Adenoma Benzo(a)pyrene 5.616695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 8.4617620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.4616835633
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 4.6410680582
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.4016712894 17306315
MESH:D000505 Alopecia Tretinoin 3.2315955085
MESH:D000544 Alzheimer Disease Ibuprofen 3.0518351690
MESH:D000690 Amyotrophic Lateral Sclerosis Thalidomide 4.0416510725
MESH:D000707 Anaphylaxis Ibuprofen 4.779532969
MESH:D000740 Anemia Fluorouracil 7.2816511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.2811748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6019183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 7.7418218290 18057881 20041841
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 7.7417460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.5615885639
MESH:D001169 Arthritis, Experimental Thalidomide 10.569598899
MESH:D001169 Arthritis, Experimental Tretinoin 10.5616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1416292516
MESH:D001249 Asthma Tretinoin 2.1816456186
MESH:D001281 Atrial Fibrillation Amiodarone 3.5419698954 18651412
MESH:D001321 Autistic Disorder Sirolimus 3.2721115397
MESH:D001471 Barrett Esophagus Tretinoin 3.9416935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.521440618 11289319
MESH:D001778 Blood Coagulation Disorders Amiodarone 18.4119483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 18.4116206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 18.4112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 18.4116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4415746008
MESH:D001859 Bone Neoplasms imatinib 4.8815867366
MESH:D001919 Bradycardia Phenylephrine 4.0615306635
MESH:D002545 Brain Ischemia Ibuprofen 4.4015837124
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.3717474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 3.3718497071 12948864 17018787 14630087 17289903 19861407 16675129 17261762
MESH:D001943 Breast Neoplasms Fluorouracil 3.3718357371 16110121 19217205 16557594 15136595 16595493 18608205
MESH:D001943 Breast Neoplasms imatinib 3.3717614352
MESH:D001943 Breast Neoplasms Tamoxifen 3.3711161223 18984771 18351453 21138602 18855134 19410462 15565566 21152245 19221464 18997820 19115204 19244106 20135344 19059307 19189212 17261762 20544844 19487384 19189210 16873071 19155303 16202921 18629630 19066611 18815881 17242785 17893378 19200415 20859285 16273361 19288272 18821012 15668708 20390343 19084267 17049068 19011961 18425577 16818667 19142967 19103187 17440819 20005174 20065188 19289846
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.3720435547
MESH:D001943 Breast Neoplasms Tretinoin 3.3716166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1016813970
MESH:D019121 Burkholderia Infections orlistat 6.1417874328
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.8811589617
MESH:D002100 Cachexia Ibuprofen 4.9815141370
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9816111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.1716051944
MESH:D002277 Carcinoma Fluorouracil 6.9017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.9016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0319066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6616168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 26.8216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 26.8216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 26.827296757 3581430
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 26.8211135700 15553829 15073043 16217749 14691202
MESH:D006528 Carcinoma, Hepatocellular Estradiol 26.8216924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 26.8217088986 16332177 16799960 18930000 17971768 17045692
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 26.8217173139 6705139 1701930 20007298 20935162
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 26.8219335982
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 26.8217306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 26.8216924424
MESH:D006528 Carcinoma, Hepatocellular Thalidomide 26.8216313753
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 26.821917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.3819014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 5.677296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 5.6718695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.6912490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.5620419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 12.5618986760 16757204 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 12.5619435901
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 12.5618572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 12.5616051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.1917572228
MESH:D006332 Cardiomegaly Phenylephrine 5.9317124262 11179087 15728586 16170337 11754973 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.9318850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7119225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.6018974383
MESH:D002386 Cataract Tretinoin 2.8017460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 17.456135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 17.457505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.4520889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 17.4518566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 17.4520056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.784080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1016129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.4016835633
MESH:D018281 Cholangiocarcinoma Thalidomide 8.4018291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 6.6519486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 6.6516105132 16919318 17681005 17110522 11677210 17333356 15861022
MESH:D002822 Choriocarcinoma Tretinoin 4.6616461808
MESH:D002916 Chylothorax orlistat 6.1417003701
MESH:D016770 Ciliophora Infections Niclosamide 5.2412113305
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.6015340226 8697196 12621046 16354765 15668235
MESH:D002972 Cleft Palate Tretinoin 8.609407595
MESH:D002972 Cleft Palate triadimefon 8.6016781842
MESH:D003092 Colitis Thalidomide 8.3216680017
MESH:D003092 Colitis Tretinoin 8.3217035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.1517169374 16510598 15001691 18772588 17172411 17016597 16340194 17287894 17018589 17725105
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.4120501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.4116524972 17016601 17401013 17094418 20501625 15289873 18383874 17594712 18949393 17255274 16282729 14970324 15148649 18448328 16331619 18802399 18509181 16391804 17454858 17695437 18288408 16303861
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6514669216 17141729
MESH:D016510 Corneal Neovascularization Thalidomide 5.109301478
MESH:D023903 Coronary Restenosis arsenic trioxide 3.7212609071
MESH:D003389 Cranial Nerve Diseases Thalidomide 5.819200351
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 8.5710525206
MESH:D019465 Craniofacial Abnormalities imatinib 8.5718322153
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 8.5720055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Thalidomide 8.579200351
MESH:D019465 Craniofacial Abnormalities Tretinoin 8.579224671 10589399 9211117 16925845 14991402 17551590 9664655 8800419 9142499 9125849
MESH:D019465 Craniofacial Abnormalities triadimefon 8.5716875885 15834900
MESH:D003424 Crohn Disease Thalidomide 3.9116078585
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.3118551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.3118551238
MESH:D007644 Darier Disease Fluorouracil 4.3016733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.6515213294
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8919031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.3618759878 12868966 8156756 2524372 8970840 11906362 11298694 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.042952479 3621924
MESH:D048909 Diabetes Complications orlistat 5.3419207292
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5417107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.4819279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.4819279558
MESH:D003967 Diarrhea orlistat 4.2720002075
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 10.1918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 10.1918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 10.197440962 9653073 6679447 16192314 6482804 9328219 18648102 9022650 18692083 8291058 11289319 1440618 18289764
MESH:D056486 Drug-Induced Liver Injury Amiodarone 10.1918218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.1920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4011462148
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.1316133044 18446180 18450898
MESH:D004421 Dystonia Phenobarbital 3.551851702
MESH:D004487 Edema imatinib 5.8119703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.2916714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.2918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.4112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.4119031437
MESH:D016889 Endometrial Neoplasms Estradiol 15.1511473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Ethylenethiourea 15.157955072
MESH:D016889 Endometrial Neoplasms Tamoxifen 15.1516202921 17893378 19155303 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 15.1516569247
MESH:D004715 Endometriosis Ibuprofen 7.8415652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.8410568697 9294722
MESH:D019446 Endotoxemia Ibuprofen 9.2011545620
MESH:D019446 Endotoxemia Lipopolysaccharides 9.2015328337 17637181 15821434
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.633659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.383922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.6320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.136401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.533659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 15.493581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.4920426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 15.4912903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 15.4916530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 15.4915173087 16481741 17638652 16785472 16337965
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 15.4915547721 15878914 16805852 15150132 15623463 15547733 16704527 15264214 16510608
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.6111564622
MESH:D005124 Eye Abnormalities Tretinoin 7.619664655 16938888
MESH:D005234 Fatty Liver Amiodarone 15.2314986274
MESH:D005234 Fatty Liver arsenic trioxide 15.2315073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.2315345470
MESH:D005234 Fatty Liver Tamoxifen 15.2314986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9811858732
MESH:D005334 Fever Ibuprofen 8.1216997862
MESH:D005334 Fever Lipopolysaccharides 8.129205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.526705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0414745880
MESH:D018222 Fibromatosis, Aggressive imatinib 10.2117453242
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.2119069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.0520067830
MESH:D005355 Fibrosis Tretinoin 7.0517994277
MESH:D005393 Fish Diseases Niclosamide 5.2012113305
MESH:D005414 Flatulence orlistat 6.1420002075
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.8016904648
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.1916452187
MESH:D005871 Giant Lymph Node Hyperplasia Thalidomide 5.8112701121
MESH:D005909 Glioblastoma Tretinoin 2.6817312396
MESH:D005910 Glioma Fluorouracil 5.7516145905
MESH:D005910 Glioma Thalidomide 5.7516327979
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.6316524712 15173396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 9.987505956
MESH:D006042 Goiter perchlorate 9.9818801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1010696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 11.1515162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Sirolimus 11.1519435901
MESH:D006258 Head and Neck Neoplasms Tretinoin 11.1516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6616084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.5020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.5010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 9.509664655 14991402
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.9616366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9011000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.056705139
MESH:D006529 Hepatomegaly Amiodarone 22.1415265979
MESH:D006529 Hepatomegaly Phenobarbital 22.1416109766
MESH:D006529 Hepatomegaly propiconazole 22.1417178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 22.1416120746 15340226 12621046
MESH:D006529 Hepatomegaly triadimefon 22.1417178689 17178688
MESH:D006558 Herpes Genitalis Estradiol 4.5315709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.7612676792
MESH:D019584 Hot Flashes Estradiol 3.2617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.558697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Tretinoin 2.8316870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.448137927 9751232
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0916778211
MESH:D006949 Hyperlipidemias orlistat 4.6421332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.4615034207
MESH:D006973 Hypertension Phenylephrine 4.628949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6218670907 18850075
MESH:D006984 Hypertrophy Ibuprofen 15.3916672835
MESH:D006984 Hypertrophy Phenylephrine 15.3912791704 18502941
MESH:D006984 Hypertrophy Sirolimus 15.3919211884
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3316945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.0417991464 18020914
MESH:D007235 Infant, Premature, Diseases Ibuprofen 5.3416133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.5417937319
MESH:D007248 Infertility, Male sodium arsenite 5.5412646999 15346721
MESH:D007249 Inflammation Flavonoids 20.0817296493
MESH:D007249 Inflammation Flurbiprofen 20.0811099482
MESH:D007249 Inflammation Ibuprofen 20.083291741
MESH:D007249 Inflammation Lipopolysaccharides 20.089205823 17255318 12878042 17963957 17237260
MESH:D007249 Inflammation Tamoxifen 20.0819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 20.0812878042 12200463
MESH:D007249 Inflammation Thalidomide 20.0816134734
MESH:D007333 Insulin Resistance Estradiol 6.8216393666 16627594
MESH:D007333 Insulin Resistance orlistat 6.8217201808
MESH:D007410 Intestinal Diseases Tretinoin 3.2917994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.1817255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.529022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 14.7316580747
MESH:D007569 Jaw Abnormalities Tretinoin 14.7317551590 15992940
MESH:D007569 Jaw Abnormalities triadimefon 14.7315834900 15992940
MESH:D007674 Kidney Diseases Estradiol 5.1315618244
MESH:D007674 Kidney Diseases sodium arsenite 5.1320008137
MESH:C531755 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules orlistat 6.1417185156
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 23.9616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 23.9616705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 23.966582329
MESH:D007680 Kidney Neoplasms Estradiol 23.9615610895
MESH:D007680 Kidney Neoplasms Fluorouracil 23.9616985049
MESH:D007680 Kidney Neoplasms Tamoxifen 23.9618625569
MESH:D007898 Leishmaniasis, Visceral Thalidomide 3.9716514283
MESH:D007938 Leukemia arsenic trioxide 5.4715070760
MESH:D007938 Leukemia Tretinoin 5.4717143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.3617077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 10.1316972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 10.1316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 12.2814633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive imatinib 12.2815107311 15748426 19208803 17301526
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive tetraarsenic tetrasulfide 12.2819208803
MESH:D007951 Leukemia, Myeloid arsenic trioxide 13.6319077051
MESH:D007951 Leukemia, Myeloid imatinib 13.6317236224
MESH:D007951 Leukemia, Myeloid Tretinoin 13.6316482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.6016467208 16968895 20471514 17050201 19850784
MESH:D015470 Leukemia, Myeloid, Acute Thalidomide 5.6018720364
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.6019850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 11.0416330433 17107899 15748426 16823087 17869043 11468182 16331271 16112521 17712046 17649720 11161223 19075265 17217047 19035177 15336539 19642359 15622746 16966277 9834237 19225113 12018890 16891316 12679006 15213294 12712474
MESH:D015473 Leukemia, Promyelocytic, Acute Thiophenes 11.0416140955 16140954
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 11.0417649720 17217047 17712046 19225113 19035177 16766008 16891316 17339181 16823087 17107899 16788101 16140955 17294898 17368321 19642359 19029980 9834237 16935935 17361223 17301526 12679006 15748426 17506722 16331271 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.8916882451
MESH:D007970 Leukopenia Lipopolysaccharides 4.2115821434
MESH:D017880 Limb Deformities, Congenital Thalidomide 7.3710473037
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.379224671
MESH:D008064 Lipidoses Amiodarone 11.3515342952 17567588
MESH:D008064 Lipidoses Perhexiline 11.3517567588 15342952
MESH:D008064 Lipidoses Tamoxifen 11.3517567588 15342952
MESH:D008103 Liver Cirrhosis orlistat 9.7417404856
MESH:D008103 Liver Cirrhosis Phenobarbital 9.7421047994
MESH:D008103 Liver Cirrhosis Thalidomide 9.7417174718 16943688
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.889327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 11.8614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental imatinib 11.8616596278
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 11.8612878042
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 11.8617050028
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 11.8618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 11.8612878042
MESH:D008106 Liver Cirrhosis, Experimental Thalidomide 11.8615465738
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 11.8616248980 18397230
MESH:D008107 Liver Diseases Phenobarbital 5.9719363144
MESH:D008107 Liver Diseases propiconazole 5.9719363144
MESH:D008107 Liver Diseases triadimefon 5.9719363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 33.817678174
MESH:D008113 Liver Neoplasms arsenic trioxide 33.8114682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 33.8121137059 20195826
MESH:D008113 Liver Neoplasms Ethylenethiourea 33.8111940454
MESH:D008113 Liver Neoplasms Fluorouracil 33.8116603448 17045692 18383874 15113037
MESH:D008113 Liver Neoplasms Phenobarbital 33.8119812893 19482888 8742319 21047994 15975961 19073162
MESH:D008113 Liver Neoplasms propiconazole 33.8119028983
MESH:D008113 Liver Neoplasms sodium arsenite 33.8115276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 33.8116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 33.8116984957
MESH:D008113 Liver Neoplasms triadimefon 33.8119028983
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 27.742876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 27.74598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 27.7420377131
MESH:D008114 Liver Neoplasms, Experimental kojic acid 27.7418544905
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 27.741399818 6150874 17172636 2563599 18308698
MESH:D008114 Liver Neoplasms, Experimental propiconazole 27.7417178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 27.7412151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 27.7417178689
MESH:D008133 Long QT Syndrome Amiodarone 6.9515350150 17391786 11989578
MESH:D008133 Long QT Syndrome arsenic trioxide 6.9515213294
MESH:D008171 Lung Diseases Amiodarone 6.4012587719
MESH:D008171 Lung Diseases sodium arsenite 6.4019095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.9818516814
MESH:D055370 Lung Injury Lipopolysaccharides 3.5421114838
MESH:D008175 Lung Neoplasms arsenic trioxide 7.5611798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 7.5618816296 20464547 20869020 18569708 20064080 18520028 17053015 6695378 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 7.5615246190
MESH:D008175 Lung Neoplasms sodium arsenite 7.5616712894 19931552 17306315 17077188 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 7.5618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.5619555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3015086387
MESH:D008207 Lymphatic Metastasis orlistat 5.4218770866 20805790
MESH:D016778 Malaria, Falciparum Perhexiline 5.5016882315
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.2819428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.2217203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 8.2210697514
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 8.2214580682 16827153 11731420 19196722 19196723
MESH:D020149 Manganese Poisoning Estradiol 10.9919453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.9919453300
MESH:D008527 Medulloblastoma Tretinoin 2.5717453147
MESH:D008545 Melanoma orlistat 11.1018770866 20805790
MESH:D008545 Melanoma Sirolimus 11.1019282848
MESH:D008545 Melanoma sodium arsenite 11.1019082730 16487513
MESH:D008545 Melanoma Tamoxifen 11.1019393235 12393984
MESH:D008545 Melanoma Thalidomide 11.1016098027 17089043 12829675
MESH:D008545 Melanoma Tretinoin 11.1016752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6915990972
MESH:D008591 Meningomyelocele Tretinoin 3.9516940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 12.3416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 12.3416757204 18986760
MESH:D009062 Mouth Neoplasms Sirolimus 12.3419435901
MESH:D009101 Multiple Myeloma arsenic trioxide 6.5219417148 11468182 14977855 19549372 15949261
MESH:D009101 Multiple Myeloma Thalidomide 6.5217168659 19112201 15939924 15867202 19372569 15744524 16445831 19112817 15741222 15920492
MESH:D009135 Muscular Diseases orlistat 4.9818430571
MESH:D009164 Mycobacterium Infections orlistat 5.0021442799
MESH:D009181 Mycoses Amiodarone 4.4012754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.1718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 10.7516882451 16105982
MESH:D009190 Myelodysplastic Syndromes Thalidomide 10.7518720364
MESH:D009190 Myelodysplastic Syndromes Tretinoin 10.7517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.9116810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9917484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.7318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.737678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.5016624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.393581430
MESH:D009362 Neoplasm Metastasis imatinib 8.3915867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.3919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 12.9911141357
MESH:D009369 Neoplasms Fluorouracil 12.9918600527 18239605 16928823
MESH:D009369 Neoplasms orlistat 12.9918710210
MESH:D009369 Neoplasms sodium arsenite 12.9911559025
MESH:D009369 Neoplasms Tretinoin 12.9916594593 16946489
MESH:D009374 Neoplasms, Experimental orlistat 8.0419381703
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.0420056578
MESH:D009376 Neoplasms, Hormone-Dependent imatinib 9.5317614352
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.5319196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 8.8817289903
MESH:D009389 Neovascularization, Pathologic orlistat 8.8817012255
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.496375363
MESH:D009410 Nerve Degeneration Ibuprofen 4.0110961664
MESH:D009421 Nervous System Malformations Estradiol 19.6916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 19.6914600291
MESH:D009421 Nervous System Malformations Thalidomide 19.6916859833
MESH:D009421 Nervous System Malformations Tretinoin 19.699125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 14.636679447
MESH:D009436 Neural Tube Defects arsenic trioxide 14.6310525206
MESH:D009436 Neural Tube Defects sodium arsenite 14.6312854658
MESH:D009436 Neural Tube Defects Tretinoin 14.639142499
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1016436463
MESH:C541083 Non-alcoholic Fatty Liver Disease orlistat 5.1217404856
MESH:D009765 Obesity orlistat 3.6319461584 19207292 20540997 20002075 20518802 16938137 21442799 20065556 18773755 19046740 21438711 20599501
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 12.6212819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 12.6216049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 12.624026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.523988306
MESH:D010003 Osteoarthritis Ibuprofen 3.837009135
MESH:D010014 Osteolysis imatinib 5.2515867366
MESH:D010018 Osteomalacia Phenobarbital 3.8817016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 16.5612452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 16.5619401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 16.5617306315 15276417
MESH:D010051 Ovarian Neoplasms Thalidomide 16.5616288038
MESH:D010051 Ovarian Neoplasms Tretinoin 16.5616936753
MESH:D010051 Ovarian Neoplasms U 0126 16.5616211241
MESH:D010146 Pain Ibuprofen 5.863291741
MESH:D010146 Pain Tretinoin 5.8616870215
MESH:D010149 Pain, Postoperative Ibuprofen 4.6516678543
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 14.2115580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 14.2119003803 16500647 16929163 15113037
MESH:D010190 Pancreatic Neoplasms Ibuprofen 14.2112384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 14.2116965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 14.2115976015
MESH:D010195 Pancreatitis orlistat 4.4020065556 16938137
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.017296757
MESH:D010235 Paraganglioma arsenic trioxide 3.7119927285
MESH:D010291 Paresis Thalidomide 5.819200351
MESH:D010300 Parkinson Disease Sirolimus 3.5519682553
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7512520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.976228378
MESH:D011014 Pneumonia Lipopolysaccharides 4.0712224865 11605937
MESH:D011085 Polycystic Ovary Syndrome orlistat 4.8617201808
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1018163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.212563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma imatinib 7.3612476293
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Thalidomide 7.3617031469
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.7111118676 11222880 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4520887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2719131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2717292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.2716740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.2719082440 18626508
MESH:D011471 Prostatic Neoplasms Flurbiprofen 3.2717409433
MESH:D011471 Prostatic Neoplasms Hyaluronic Acid 3.2716864594
MESH:D011471 Prostatic Neoplasms Ibuprofen 3.2717409433
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2716039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2715067354
MESH:D011471 Prostatic Neoplasms Thalidomide 3.2716729912
MESH:D011507 Proteinuria Ibuprofen 8.026375363
MESH:D011507 Proteinuria Tretinoin 8.0216636307
MESH:D011536 Prurigo Thalidomide 5.8112755975
MESH:D011537 Pruritus Ethinyl Estradiol 2.8316919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.0012752131
MESH:D011625 Pterygium Tretinoin 4.3016723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.6511597910 12832656 12490602
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6018286688 15538739 16160472 18722050
MESH:D012035 Refsum Disease orlistat 5.5820871815
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4010835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.013692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6516116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.5016646077
MESH:D019873 Schnitzler Syndrome Thalidomide 5.4516096327
MESH:D012640 Seizures 2,4-dinitrotoluene 7.8518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 7.8518551238
MESH:D012640 Seizures Phenobarbital 7.853137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.336407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.6018724381
MESH:D012852 Sinusitis Phenylephrine 4.227327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 11.4919755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 11.4918572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.4916192470
MESH:D012878 Skin Neoplasms Tretinoin 11.4916467112
MESH:D013088 Spermatocele Ethinyl Estradiol 9.9116709447
MESH:D013088 Spermatocele Tamoxifen 9.9116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.5519457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4212854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 9.3917007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 9.3920155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 9.3916951190 17522103 19015929 18396642 15786421 17172411 17498489 16424979 18567086 19084572
MESH:D013274 Stomach Neoplasms imatinib 9.3915786421
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 9.3912958204 17575124
MESH:D013274 Stomach Neoplasms orlistat 9.3919381703
MESH:D013274 Stomach Neoplasms Tretinoin 9.3917261132
MESH:D013276 Stomach Ulcer Amiodarone 6.3018087811
MESH:D013276 Stomach Ulcer Thalidomide 6.3015138204
MESH:D013610 Tachycardia Amiodarone 3.8311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.7319225199
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.7415821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7415669648
MESH:D013959 Thyroid Diseases Amiodarone 10.4019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.4012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 28.076587162 6582329 7505956 3712494 1399818
MESH:D013964 Thyroid Neoplasms arsenic trioxide 28.0719014326
MESH:D013964 Thyroid Neoplasms Ethylenethiourea 28.0711940454
MESH:D013964 Thyroid Neoplasms imatinib 28.0716940797
MESH:D013964 Thyroid Neoplasms Phenobarbital 28.071399818
MESH:D013964 Thyroid Neoplasms Tretinoin 28.0717045167 16026305
MESH:D013964 Thyroid Neoplasms triadimefon 28.0717178689
MESH:D013971 Thyrotoxicosis Amiodarone 4.3819584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.1919048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.4216280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.4216051514
MESH:D016171 Torsades de Pointes Amiodarone 8.6417467628 11989578
MESH:D016171 Torsades de Pointes arsenic trioxide 8.6415213294
MESH:D014376 Tuberculosis Tretinoin 2.9116040207
MESH:D014402 Tuberous Sclerosis everolimus 11.2718495876
MESH:D014402 Tuberous Sclerosis Sirolimus 11.2718495876 21115397
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 20.8516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 20.8516049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 20.858074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 20.8511780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 20.8517053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 20.8516712894 11723127 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 20.8516712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.3710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.3710091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 13.4116803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.4111813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 13.4116129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8414692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.1116752155
MESH:D014605 Uveitis Sirolimus 5.141336536
MESH:D014652 Vascular Diseases sodium arsenite 10.5017056641
MESH:D014652 Vascular Diseases Thalidomide 10.5015741222
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1012125929
MESH:D020301 Vasospasm, Intracranial Ibuprofen 4.7019057314
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1015869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.5916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7515886252
MESH:D009396 Wilms Tumor Tretinoin 3.5616287080
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:71 Gene Expression
KEGG:04910 Insulin signaling pathway
REACT:17015 Metabolism of proteins
REACT:21257 Metabolism of RNA
REACT:1675 mRNA Processing
KEGG:04150 mTOR signaling pathway
KEGG:03013 RNA transport
REACT:498 Signaling by Insulin receptor
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27714
    • No data
    No data
    Releated drug ID Related drug Name
    PA451365sirolimus
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01649 - 7-Methyl-Gpppa
    DB01960 - 7n-Methyl-8-Hydroguanosine-5'-Diphosphate
    DB02716 - 7-Methyl-Guanosine-5'-Triphosphate
    DB08217 - 2,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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