AutismKB 2.0

Annotation Detail for EIF4G1


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Basic Information Top
Gene Symbol:EIF4G1 ( DKFZp686A1451,EIF-4G1,EIF4F,EIF4G,EIF4GI,P220 )
Gene Full Name: eukaryotic translation initiation factor 4 gamma, 1
Band: 3q27.1
Quick LinksEntrez ID:1981; OMIM: 600495; Uniprot ID:IF4G1_HUMAN; ENSEMBL ID: ENSG00000114867; HGNC ID: 3296
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05416Viral myocarditis
Pathway IDPathway Name
Metabolism of proteins
Metabolism of RNA
Signaling by Insulin receptor
Gene Expression
3' -UTR-mediated translational regulation
Pathway IDPathway Name
200045Validated targets of C-MYC transcriptional activation
No data
Pathway IDPathway Name
500993S6K1 signalling
500901Cap-dependent Translation Initiation
500855Deadenylation of mRNA
500880Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 4
500970GTP hydrolysis and joining of the 60S ribosomal subunit
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1944Breast cancer
1976Squamous cell cancer
2052Infection
2118Adenovirus infection
2248Cytomegalovirus infection
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of EIF4G1 mRNAaffects expression 17562736
D003474 Curcumin Curcumin results in decreased phosphorylation of EIF4G1 proteindecreases phosphorylation 18790744
C014347 decitabine decitabine results in increased expression of EIF4G1 mRNAincreases expression 17908484
D004041 Dietary Fats Dietary Fats results in decreased expression of EIF4G1 mRNAdecreases expression 18042831
D004958 Estradiol Estradiol results in increased phosphorylation of EIF4G1 proteinincreases phosphorylation 16033851
D004958 Estradiol everolimus inhibits the reaction [Estradiol results in increased phosphorylation of EIF4G1 protein]decreases reaction|increases phosphorylation 16033851
C107135 everolimus everolimus inhibits the reaction [Estradiol results in increased phosphorylation of EIF4G1 protein]decreases reaction|increases phosphorylation 16033851
C015329 lycopene lycopene results in increased expression of EIF4G1 mRNAincreases expression 16886892
C041786 palm oil palm oil results in decreased expression of EIF4G1 mRNAdecreases expression 18042831
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of EIF4G1 mRNAdecreases expression 17616710
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of EIF4G1 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in increased expression of EIF4G1 mRNAincreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of EIF4G1 mRNAincreases expression 18175754
C004648 testosterone enanthate testosterone enanthate affects the expression of EIF4G1 mRNAaffects expression 17440010
C025643 vinclozolin vinclozolin results in decreased expression of EIF4G1 mRNAdecreases expression 18042343
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of EIF4G1 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of EIF4G1 mRNAdecreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of EIF4G1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1111473722
MESH:D019973 Alcohol-Related Disorders Curcumin 5.1817887948
MESH:D000544 Alzheimer Disease Curcumin 2.6315590663
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6819015723
MESH:D001161 Arteriosclerosis Dietary Fats 3.9615238619
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7516807698
MESH:D050197 Atherosclerosis Curcumin 3.3518704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Curcumin 4.5619761891
MESH:D002545 Brain Ischemia Curcumin 4.4116770732
MESH:D001932 Brain Neoplasms Curcumin 3.9917596214
MESH:D001943 Breast Neoplasms Curcumin 2.0019250217 18462866 18593918 16243823
MESH:D001943 Breast Neoplasms decitabine 2.0018320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 2.0020435547
MESH:D001943 Breast Neoplasms Estradiol 2.0016675129 12948864 17018787 17289903 17261762 19861407 14630087 18497071
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0016050911
MESH:D002277 Carcinoma Curcumin 3.8818593918
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.843084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.8416924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9918414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 4.9918462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.9919215824
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8118566989
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8215894690
MESH:D003092 Colitis Curcumin 9.9118200517 16782535 16804969
MESH:D003092 Colitis Selenium 9.9117936198
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6620423518
MESH:D003103 Coloboma Curcumin 4.6018809619
MESH:D003110 Colonic Neoplasms Curcumin 4.0016340194 19359593
MESH:D003110 Colonic Neoplasms decitabine 4.0017616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D016510 Corneal Neovascularization Curcumin 4.9718497527
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9119769572
MESH:D003456 Cryptorchidism vinclozolin 4.4114966744
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8216285004
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7118403477
MESH:D003928 Diabetic Nephropathies Curcumin 9.2018204486
MESH:D003928 Diabetic Nephropathies Estradiol 9.2019279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3310774834 17906064 15968718 16081117 16393943 12705907 15619225 16177239 12594235 17522070 19370779 19085960 19164858 11421492 12392966 14725611 17562736 11834606 10663392 16781746 11529661 16227642 11739529 18071297 14550746 11461765 10915739 14986274 16485898 19416960 18713872 16109766 11743745 12958197 19739265 19420014 12153990 11287661 12540782 2444490 19923254
MESH:D056486 Drug-Induced Liver Injury Selenium 6.3315131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.3315131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004381 Duodenal Ulcer Curcumin 4.1117351913
MESH:D050171 Dyslipidemias Dietary Fats 3.4918367378
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2119294695
MESH:D016889 Endometrial Neoplasms Estradiol 3.0111473722 19148513 18566989
MESH:D005234 Fatty Liver Curcumin 8.2319297423
MESH:D005234 Fatty Liver Dietary Fats 8.2317967931 18296743 19004024 19551842
MESH:D005355 Fibrosis Curcumin 9.2518705752
MESH:D005355 Fibrosis Dietary Fats 9.2518296743
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.7718462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4016417039
MESH:D005909 Glioblastoma Curcumin 3.5117596214
MESH:D006258 Head and Neck Neoplasms Curcumin 8.1218462866 18829502
MESH:D006258 Head and Neck Neoplasms decitabine 8.1219215824
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0116080930
MESH:D006333 Heart Failure Selenium 3.1117162251
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.1117701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8417440010
MESH:D019584 Hot Flashes Estradiol 10.3817088409
MESH:D019584 Hot Flashes Vitamin E 10.3814716179
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006937 Hypercholesterolemia Curcumin 9.4218704882
MESH:D006937 Hypercholesterolemia Dietary Fats 9.4221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6721332399
MESH:D007248 Infertility, Male decitabine 7.0417581917
MESH:D007248 Infertility, Male vinclozolin 7.0416467254
MESH:D007249 Inflammation Curcumin 5.3817151092 18403477 16956363
MESH:D007249 Inflammation Dietary Fats 5.3820412841
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2318200517 18596194
MESH:D007251 Influenza, Human Selenium 11.2916624496
MESH:D007251 Influenza, Human Vitamin E 11.2916624496
MESH:D007333 Insulin Resistance Dietary Fats 12.5818457598 11836018
MESH:D007333 Insulin Resistance Estradiol 12.5816393666 16627594
MESH:D007333 Insulin Resistance Sodium Selenite 12.5814714311
MESH:D007414 Intestinal Neoplasms Curcumin 4.2710783313
MESH:D007674 Kidney Diseases Acetaminophen 10.2112587719 15629191
MESH:D007674 Kidney Diseases Estradiol 10.2115618244
MESH:D007674 Kidney Diseases Vitamin E 10.2112488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms Estradiol 3.0215610895
MESH:D007889 Leiomyoma Curcumin 4.6318555241
MESH:D007938 Leukemia Curcumin 6.6918462866
MESH:D007938 Leukemia decitabine 6.6919235587 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.2616106398
MESH:D007951 Leukemia, Myeloid decitabine 4.0619117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3918206229 19010910 19387464 18460780 18704418 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.5618055864
MESH:D015458 Leukemia, T-Cell Curcumin 4.8316106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8116417039
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9018296743
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.6218006644 17355460 18705752
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.6216169303
MESH:D008107 Liver Diseases Acetaminophen 4.1419460945 16610002 19784758 11587558 12969438 16611625 19014921 12587719
MESH:D008107 Liver Diseases Curcumin 4.1416956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2916871587 17185352
MESH:D008171 Lung Diseases Vitamin E 3.2116863852
MESH:D008175 Lung Neoplasms Curcumin 2.7019359593 16243823 18462866
MESH:D008175 Lung Neoplasms Vitamin E 2.7011062179
MESH:D008223 Lymphoma Curcumin 7.9018462866
MESH:D008223 Lymphoma decitabine 7.9019470736
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1214737004
MESH:D016399 Lymphoma, T-Cell Curcumin 4.7716173963
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1311807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.1315318939
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008545 Melanoma Curcumin 3.6217885582 18462866
MESH:D008545 Melanoma decitabine 3.6217785578 16505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008569 Memory Disorders Curcumin 4.2217263510
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D009101 Multiple Myeloma Curcumin 7.6619372569
MESH:D009101 Multiple Myeloma decitabine 7.6618172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.0017962980
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4119157545 16882708 19010910 18608210
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3216810080
MESH:D009361 Neoplasm Invasiveness Curcumin 4.4318495463
MESH:D009369 Neoplasms decitabine 5.7619116145 17925555 19470736
MESH:D009369 Neoplasms lycopene 5.7617051425
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.6312497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009421 Nervous System Malformations Estradiol 3.7211399458 16427766
MESH:D009423 Nervous System Neoplasms Curcumin 5.7318462866
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009765 Obesity Curcumin 4.8219297423
MESH:D009765 Obesity Dietary Fats 4.8221332399 18457598 20518802 16723640 17217161 18674790 19632207 20132043 11836018
MESH:D010024 Osteoporosis Curcumin 3.5018719352
MESH:D010051 Ovarian Neoplasms Curcumin 8.0619020741 18462866
MESH:D010051 Ovarian Neoplasms decitabine 8.0619331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 8.0619401270
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Curcumin 5.6117440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms decitabine 5.6119294695
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.9819015723 18220299 18042343
MESH:D055728 Primary Myelofibrosis decitabine 4.8017616702
MESH:D011469 Prostatic Diseases vinclozolin 5.0218220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Curcumin 1.8911398177 10851300 12497104 18769126 18156803 18226269 15129424
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms lycopene 1.8915084515 17337101
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.8918760546
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8915084515
MESH:D011472 Prostatitis vinclozolin 5.0218629315
MESH:D011656 Pulmonary Emphysema Curcumin 4.5819168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.0818379247 10666014
MESH:D012208 Rhabdomyosarcoma decitabine 4.4619155313
MESH:D012509 Sarcoma Curcumin 4.1718462866
MESH:D018805 Sepsis Curcumin 4.1218389075
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013276 Stomach Ulcer Curcumin 3.5516631530 19188055
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 5.0315864552
MESH:D013964 Thyroid Neoplasms decitabine 3.3717967635
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D014402 Tuberous Sclerosis everolimus 6.5918495876
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.4618593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.4617616700 19087683
MESH:D014565 Urogenital Neoplasms Curcumin 5.3518462866
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014604 Uveal Neoplasms decitabine 5.0117785578
MESH:D015430 Weight Gain Dietary Fats 3.7916723640
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:71 Gene Expression
REACT:17015 Metabolism of proteins
REACT:21257 Metabolism of RNA
KEGG:03013 RNA transport
REACT:498 Signaling by Insulin receptor
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27722
  • No data
    No data
    Releated drug ID Related drug Name
    PA451365sirolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018