Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
---|
D000082 |
Acetaminophen |
Acetaminophen affects the expression of EIF4G1 mRNA | affects expression | 17562736
|
D003474 |
Curcumin |
Curcumin results in decreased phosphorylation of EIF4G1 protein | decreases phosphorylation | 18790744
|
C014347 |
decitabine |
decitabine results in increased expression of EIF4G1 mRNA | increases expression | 17908484
|
D004041 |
Dietary Fats |
Dietary Fats results in decreased expression of EIF4G1 mRNA | decreases expression | 18042831
|
D004958 |
Estradiol |
Estradiol results in increased phosphorylation of EIF4G1 protein | increases phosphorylation | 16033851
|
D004958 |
Estradiol |
everolimus inhibits the reaction [Estradiol results in increased phosphorylation of EIF4G1 protein] | decreases reaction|increases phosphorylation | 16033851
|
C107135 |
everolimus |
everolimus inhibits the reaction [Estradiol results in increased phosphorylation of EIF4G1 protein] | decreases reaction|increases phosphorylation | 16033851
|
C015329 |
lycopene |
lycopene results in increased expression of EIF4G1 mRNA | increases expression | 16886892
|
C041786 |
palm oil |
palm oil results in decreased expression of EIF4G1 mRNA | decreases expression | 18042831
|
C058305 |
phenethyl isothiocyanate |
phenethyl isothiocyanate results in decreased expression of EIF4G1 mRNA | decreases expression | 17616710
|
D012643 |
Selenium |
[Selenium co-treated with Vitamin E] results in decreased expression of EIF4G1 mRNA | affects cotreatment|decreases expression | 19244175
|
D012643 |
Selenium |
Selenium results in increased expression of EIF4G1 mRNA | increases expression | 19244175
|
D018038 |
Sodium Selenite |
Sodium Selenite results in increased expression of EIF4G1 mRNA | increases expression | 18175754
|
C004648 |
testosterone enanthate |
testosterone enanthate affects the expression of EIF4G1 mRNA | affects expression | 17440010
|
C025643 |
vinclozolin |
vinclozolin results in decreased expression of EIF4G1 mRNA | decreases expression | 18042343
|
D014810 |
Vitamin E |
[Selenium co-treated with Vitamin E] results in decreased expression of EIF4G1 mRNA | affects cotreatment|decreases expression | 19244175
|
D014810 |
Vitamin E |
Vitamin E results in decreased expression of EIF4G1 mRNA | decreases expression | 19244175
|
D014810 |
Vitamin E |
Vitamin E results in increased expression of EIF4G1 mRNA | increases expression | 19244175
|
Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
---|
MESH:D000230 |
Adenocarcinoma |
|
Estradiol |
2.11 | 11473722 |
MESH:D019973 |
Alcohol-Related Disorders |
|
Curcumin |
5.18 | 17887948 |
MESH:D000544 |
Alzheimer Disease |
|
Curcumin |
2.63 | 15590663 |
MESH:D000799 |
Angioedema |
|
Acetaminophen |
3.94 | 10982225 |
MESH:D001008 |
Anxiety Disorders |
|
vinclozolin |
3.68 | 19015723 |
MESH:D001161 |
Arteriosclerosis |
|
Dietary Fats |
3.96 | 15238619 |
MESH:D001172 |
Arthritis, Rheumatoid |
|
Curcumin |
2.75 | 16807698 |
MESH:D050197 |
Atherosclerosis |
|
Curcumin |
3.35 | 18704882 |
MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.41 | 18445737 |
MESH:D001327 |
Autoimmune Diseases |
|
Curcumin |
4.56 | 19761891 |
MESH:D002545 |
Brain Ischemia |
|
Curcumin |
4.41 | 16770732 |
MESH:D001932 |
Brain Neoplasms |
|
Curcumin |
3.99 | 17596214 |
MESH:D001943 |
Breast Neoplasms |
|
Curcumin |
2.00 | 19250217 18462866 18593918 16243823 |
MESH:D001943 |
Breast Neoplasms |
|
decitabine |
2.00 | 18320071 19208741 |
MESH:D001943 |
Breast Neoplasms |
|
Dietary Fats |
2.00 | 20435547 |
MESH:D001943 |
Breast Neoplasms |
|
Estradiol |
2.00 | 16675129 12948864 17018787 17289903 17261762 19861407 14630087 18497071 |
MESH:D002181 |
Candidiasis, Vulvovaginal |
|
Estradiol |
4.55 | 16111702 |
MESH:D002252 |
Carbon Tetrachloride Poisoning |
|
Vitamin E |
4.00 | 16050911 |
MESH:D002277 |
Carcinoma |
|
Curcumin |
3.88 | 18593918 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
2.84 | 3084413 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Estradiol |
2.84 | 16924424 |
MESH:D002289 |
Carcinoma, Non-Small-Cell Lung |
|
Curcumin |
2.99 | 18414057 |
MESH:D002294 |
Carcinoma, Squamous Cell |
|
Curcumin |
4.99 | 18462866 |
MESH:D002294 |
Carcinoma, Squamous Cell |
|
decitabine |
4.99 | 19215824 |
MESH:D002386 |
Cataract |
|
Acetaminophen |
2.61 | 10977129 |
MESH:D002471 |
Cell Transformation, Neoplastic |
|
Estradiol |
2.81 | 18566989 |
MESH:D019457 |
Chromosome Breakage |
|
Sodium Selenite |
4.82 | 15894690 |
MESH:D003092 |
Colitis |
|
Curcumin |
9.91 | 18200517 16782535 16804969 |
MESH:D003092 |
Colitis |
|
Selenium |
9.91 | 17936198 |
MESH:D003093 |
Colitis, Ulcerative |
|
phenethyl isothiocyanate |
3.66 | 20423518 |
MESH:D003103 |
Coloboma |
|
Curcumin |
4.60 | 18809619 |
MESH:D003110 |
Colonic Neoplasms |
|
Curcumin |
4.00 | 16340194 19359593 |
MESH:D003110 |
Colonic Neoplasms |
|
decitabine |
4.00 | 17616700 |
MESH:D015179 |
Colorectal Neoplasms |
|
decitabine |
2.10 | 18981723 |
MESH:D016510 |
Corneal Neovascularization |
|
Curcumin |
4.97 | 18497527 |
MESH:D019465 |
Craniofacial Abnormalities |
|
Vitamin E |
1.91 | 19769572 |
MESH:D003456 |
Cryptorchidism |
|
vinclozolin |
4.41 | 14966744 |
MESH:D003920 |
Diabetes Mellitus |
|
Sodium Selenite |
3.82 | 16285004 |
MESH:D003924 |
Diabetes Mellitus, Type 2 |
|
Curcumin |
2.71 | 18403477 |
MESH:D003928 |
Diabetic Nephropathies |
|
Curcumin |
9.20 | 18204486 |
MESH:D003928 |
Diabetic Nephropathies |
|
Estradiol |
9.20 | 19279558 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
6.33 | 10774834 17906064 15968718 16081117 16393943 12705907 15619225 16177239 12594235 17522070 19370779 19085960 19164858 11421492 12392966 14725611 17562736 11834606 10663392 16781746 11529661 16227642 11739529 18071297 14550746 11461765 10915739 14986274 16485898 19416960 18713872 16109766 11743745 12958197 19739265 19420014 12153990 11287661 12540782 2444490 19923254 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Selenium |
6.33 | 15131321 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Sodium Selenite |
6.33 | 15131321 |
MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.19 | 19426721 |
MESH:D004381 |
Duodenal Ulcer |
|
Curcumin |
4.11 | 17351913 |
MESH:D050171 |
Dyslipidemias |
|
Dietary Fats |
3.49 | 18367378 |
MESH:C538011 |
Eales disease |
|
Vitamin E |
4.80 | 9068938 |
MESH:D004701 |
Endocrine Gland Neoplasms |
|
decitabine |
5.21 | 19294695 |
MESH:D016889 |
Endometrial Neoplasms |
|
Estradiol |
3.01 | 11473722 19148513 18566989 |
MESH:D005234 |
Fatty Liver |
|
Curcumin |
8.23 | 19297423 |
MESH:D005234 |
Fatty Liver |
|
Dietary Fats |
8.23 | 17967931 18296743 19004024 19551842 |
MESH:D005355 |
Fibrosis |
|
Curcumin |
9.25 | 18705752 |
MESH:D005355 |
Fibrosis |
|
Dietary Fats |
9.25 | 18296743 |
MESH:D005756 |
Gastritis |
|
Acetaminophen |
3.77 | 16983495 |
MESH:D005770 |
Gastrointestinal Neoplasms |
|
Curcumin |
4.77 | 18462866 |
MESH:D030342 |
Genetic Diseases, Inborn |
|
vinclozolin |
5.02 | 16973722 |
MESH:D005832 |
Genital Diseases, Male |
|
vinclozolin |
5.40 | 16417039 |
MESH:D005909 |
Glioblastoma |
|
Curcumin |
3.51 | 17596214 |
MESH:D006258 |
Head and Neck Neoplasms |
|
Curcumin |
8.12 | 18462866 18829502 |
MESH:D006258 |
Head and Neck Neoplasms |
|
decitabine |
8.12 | 19215824 |
MESH:D006330 |
Heart Defects, Congenital |
|
Vitamin E |
3.01 | 16080930 |
MESH:D006333 |
Heart Failure |
|
Selenium |
3.11 | 17162251 |
MESH:D015417 |
Hereditary Sensory and Motor Neuropathy |
|
Curcumin |
5.11 | 17701891 |
MESH:D006548 |
Hernia, Diaphragmatic |
|
Vitamin E |
2.72 | 16863852 16490937 |
MESH:D006558 |
Herpes Genitalis |
|
Estradiol |
5.13 | 15709030 |
MESH:D019247 |
HIV Wasting Syndrome |
|
testosterone enanthate |
5.84 | 17440010 |
MESH:D019584 |
Hot Flashes |
|
Estradiol |
10.38 | 17088409 |
MESH:D019584 |
Hot Flashes |
|
Vitamin E |
10.38 | 14716179 |
MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
2.74 | 16870215 |
MESH:D006937 |
Hypercholesterolemia |
|
Curcumin |
9.42 | 18704882 |
MESH:D006937 |
Hypercholesterolemia |
|
Dietary Fats |
9.42 | 21332399 |
MESH:D006949 |
Hyperlipidemias |
|
Dietary Fats |
3.67 | 21332399 |
MESH:D007248 |
Infertility, Male |
|
decitabine |
7.04 | 17581917 |
MESH:D007248 |
Infertility, Male |
|
vinclozolin |
7.04 | 16467254 |
MESH:D007249 |
Inflammation |
|
Curcumin |
5.38 | 17151092 18403477 16956363 |
MESH:D007249 |
Inflammation |
|
Dietary Fats |
5.38 | 20412841 |
MESH:D015212 |
Inflammatory Bowel Diseases |
|
Curcumin |
3.23 | 18200517 18596194 |
MESH:D007251 |
Influenza, Human |
|
Selenium |
11.29 | 16624496 |
MESH:D007251 |
Influenza, Human |
|
Vitamin E |
11.29 | 16624496 |
MESH:D007333 |
Insulin Resistance |
|
Dietary Fats |
12.58 | 18457598 11836018 |
MESH:D007333 |
Insulin Resistance |
|
Estradiol |
12.58 | 16393666 16627594 |
MESH:D007333 |
Insulin Resistance |
|
Sodium Selenite |
12.58 | 14714311 |
MESH:D007414 |
Intestinal Neoplasms |
|
Curcumin |
4.27 | 10783313 |
MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
10.21 | 12587719 15629191 |
MESH:D007674 |
Kidney Diseases |
|
Estradiol |
10.21 | 15618244 |
MESH:D007674 |
Kidney Diseases |
|
Vitamin E |
10.21 | 12488133 |
MESH:D007676 |
Kidney Failure, Chronic |
|
Selenium |
3.94 | 16518626 |
MESH:D007680 |
Kidney Neoplasms |
|
Estradiol |
3.02 | 15610895 |
MESH:D007889 |
Leiomyoma |
|
Curcumin |
4.63 | 18555241 |
MESH:D007938 |
Leukemia |
|
Curcumin |
6.69 | 18462866 |
MESH:D007938 |
Leukemia |
|
decitabine |
6.69 | 19235587 18980019 |
MESH:D015459 |
Leukemia-Lymphoma, Adult T-Cell |
|
Curcumin |
4.26 | 16106398 |
MESH:D007951 |
Leukemia, Myeloid |
|
decitabine |
4.06 | 19117987 18454857 17236224 |
MESH:D015470 |
Leukemia, Myeloid, Acute |
|
decitabine |
2.39 | 18206229 19010910 19387464 18460780 18704418 17679729 |
MESH:D015477 |
Leukemia, Myelomonocytic, Chronic |
|
decitabine |
5.56 | 18055864 |
MESH:D015458 |
Leukemia, T-Cell |
|
Curcumin |
4.83 | 16106398 |
MESH:D007984 |
Leydig Cell Tumor |
|
vinclozolin |
4.81 | 16417039 |
MESH:D008103 |
Liver Cirrhosis |
|
Dietary Fats |
2.90 | 18296743 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Curcumin |
3.62 | 18006644 17355460 18705752 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Estradiol |
3.62 | 14716833 14659978 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Vitamin E |
3.62 | 16169303 |
MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
4.14 | 19460945 16610002 19784758 11587558 12969438 16611625 19014921 12587719 |
MESH:D008107 |
Liver Diseases |
|
Curcumin |
4.14 | 16956363 |
MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.29 | 16871587 17185352 |
MESH:D008171 |
Lung Diseases |
|
Vitamin E |
3.21 | 16863852 |
MESH:D008175 |
Lung Neoplasms |
|
Curcumin |
2.70 | 19359593 16243823 18462866 |
MESH:D008175 |
Lung Neoplasms |
|
Vitamin E |
2.70 | 11062179 |
MESH:D008223 |
Lymphoma |
|
Curcumin |
7.90 | 18462866 |
MESH:D008223 |
Lymphoma |
|
decitabine |
7.90 | 19470736 |
MESH:D016393 |
Lymphoma, B-Cell |
|
Sodium Selenite |
4.12 | 14737004 |
MESH:D016399 |
Lymphoma, T-Cell |
|
Curcumin |
4.77 | 16173963 |
MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Estradiol |
6.13 | 11807958 16891317 11408345 17203775 |
MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Selenium |
6.13 | 15318939 |
MESH:D020149 |
Manganese Poisoning |
|
Estradiol |
4.58 | 19453300 |
MESH:D008545 |
Melanoma |
|
Curcumin |
3.62 | 17885582 18462866 |
MESH:D008545 |
Melanoma |
|
decitabine |
3.62 | 17785578 16505122 |
MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
3.64 | 19513568 |
MESH:D008569 |
Memory Disorders |
|
Curcumin |
4.22 | 17263510 |
MESH:D008654 |
Mesothelioma |
|
Selenium |
2.81 | 15107826 |
MESH:D009101 |
Multiple Myeloma |
|
Curcumin |
7.66 | 19372569 |
MESH:D009101 |
Multiple Myeloma |
|
decitabine |
7.66 | 18172295 |
MESH:D009134 |
Muscular Atrophy, Spinal |
|
Curcumin |
5.00 | 17962980 |
MESH:D009190 |
Myelodysplastic Syndromes |
|
decitabine |
3.41 | 19157545 16882708 19010910 18608210 |
MESH:D015428 |
Myocardial Reperfusion Injury |
|
Estradiol |
3.32 | 16810080 |
MESH:D009361 |
Neoplasm Invasiveness |
|
Curcumin |
4.43 | 18495463 |
MESH:D009369 |
Neoplasms |
|
decitabine |
5.76 | 19116145 17925555 19470736 |
MESH:D009369 |
Neoplasms |
|
lycopene |
5.76 | 17051425 |
MESH:D009376 |
Neoplasms, Hormone-Dependent |
|
Curcumin |
4.63 | 12497104 |
MESH:D009389 |
Neovascularization, Pathologic |
|
Estradiol |
3.81 | 17289903 |
MESH:D009421 |
Nervous System Malformations |
|
Estradiol |
3.72 | 11399458 16427766 |
MESH:D009423 |
Nervous System Neoplasms |
|
Curcumin |
5.73 | 18462866 |
MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
2.91 | 18514411 |
MESH:D009765 |
Obesity |
|
Curcumin |
4.82 | 19297423 |
MESH:D009765 |
Obesity |
|
Dietary Fats |
4.82 | 21332399 18457598 20518802 16723640 17217161 18674790 19632207 20132043 11836018 |
MESH:D010024 |
Osteoporosis |
|
Curcumin |
3.50 | 18719352 |
MESH:D010051 |
Ovarian Neoplasms |
|
Curcumin |
8.06 | 19020741 18462866 |
MESH:D010051 |
Ovarian Neoplasms |
|
decitabine |
8.06 | 19331143 19259094 |
MESH:D010051 |
Ovarian Neoplasms |
|
Estradiol |
8.06 | 19401270 |
MESH:D010146 |
Pain |
|
Acetaminophen |
2.43 | 16870215 |
MESH:D010190 |
Pancreatic Neoplasms |
|
Curcumin |
5.61 | 17440100 19401701 19196508 |
MESH:D010190 |
Pancreatic Neoplasms |
|
decitabine |
5.61 | 19294695 |
MESH:D010954 |
Plasmacytoma |
|
Selenium |
4.99 | 15087411 |
MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
vinclozolin |
3.98 | 19015723 18220299 18042343 |
MESH:D055728 |
Primary Myelofibrosis |
|
decitabine |
4.80 | 17616702 |
MESH:D011469 |
Prostatic Diseases |
|
vinclozolin |
5.02 | 18220299 |
MESH:D019048 |
Prostatic Intraepithelial Neoplasia |
|
Estradiol |
3.94 | 20887781 |
MESH:D011471 |
Prostatic Neoplasms |
|
Curcumin |
1.89 | 11398177 10851300 12497104 18769126 18156803 18226269 15129424 |
MESH:D011471 |
Prostatic Neoplasms |
|
Estradiol |
1.89 | 16740699 |
MESH:D011471 |
Prostatic Neoplasms |
|
lycopene |
1.89 | 15084515 17337101 |
MESH:D011471 |
Prostatic Neoplasms |
|
Sodium Selenite |
1.89 | 18760546 |
MESH:D011471 |
Prostatic Neoplasms |
|
Vitamin E |
1.89 | 15084515 |
MESH:D011472 |
Prostatitis |
|
vinclozolin |
5.02 | 18629315 |
MESH:D011656 |
Pulmonary Emphysema |
|
Curcumin |
4.58 | 19168576 |
MESH:D012128 |
Respiratory Distress Syndrome, Adult |
|
Curcumin |
4.08 | 18379247 10666014 |
MESH:D012208 |
Rhabdomyosarcoma |
|
decitabine |
4.46 | 19155313 |
MESH:D012509 |
Sarcoma |
|
Curcumin |
4.17 | 18462866 |
MESH:D018805 |
Sepsis |
|
Curcumin |
4.12 | 18389075 |
MESH:D012871 |
Skin Diseases |
|
Vitamin E |
2.45 | 18709164 |
MESH:D013274 |
Stomach Neoplasms |
|
decitabine |
2.10 | 19037991 |
MESH:D013276 |
Stomach Ulcer |
|
Curcumin |
3.55 | 16631530 19188055 |
MESH:D020521 |
Stroke |
|
Vitamin E |
3.56 | 16517955 |
MESH:D013733 |
Testicular Diseases |
|
phenethyl isothiocyanate |
5.03 | 15864552 |
MESH:D013964 |
Thyroid Neoplasms |
|
decitabine |
3.37 | 17967635 |
MESH:D013978 |
Tibial Fractures |
|
Estradiol |
4.78 | 19048282 |
MESH:D014402 |
Tuberous Sclerosis |
|
everolimus |
6.59 | 18495876 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
Curcumin |
5.46 | 18593936 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
decitabine |
5.46 | 17616700 19087683 |
MESH:D014565 |
Urogenital Neoplasms |
|
Curcumin |
5.35 | 18462866 |
MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.03 | 10982225 |
MESH:D014604 |
Uveal Neoplasms |
|
decitabine |
5.01 | 17785578 |
MESH:D015430 |
Weight Gain |
|
Dietary Fats |
3.79 | 16723640 |