AutismKB 2.0

Annotation Detail for EIF4G2


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Basic Information Top
Gene Symbol:EIF4G2 ( AAG1,DAP5,FLJ41344,NAT1,P97 )
Gene Full Name: eukaryotic translation initiation factor 4 gamma, 2
Band: 11p15.4
Quick LinksEntrez ID:1982; OMIM: 602325; Uniprot ID:IF4G2_HUMAN; ENSEMBL ID: ENSG00000110321; HGNC ID: 3297
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of EIF4G2 proteinincreases expression 18491231
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of EIF4G2 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of EIF4G2 mRNAdecreases expression 12958071
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of EIF4G2 mRNAincreases expression 18648102
C006632 arsenic trioxide arsenic trioxide results in increased cleavage of EIF4G2 proteinincreases cleavage 18491231
D001554 Benzene Benzene results in increased expression of EIF4G2 mRNAincreases expression 15878777
D002117 Calcitriol Calcitriol results in increased expression of EIF4G2 proteinincreases expression 18491231
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide results in increased expression of EIF4G2 proteinincreases expression 18491231
D004958 Estradiol Estradiol affects the expression of EIF4G2 mRNAaffects expression 15598610
C008493 methylselenic acid methylselenic acid results in decreased expression of EIF4G2 mRNAdecreases expression 12517777
C487081 PXD101 PXD101 results in decreased expression of EIF4G2 mRNAdecreases expression 19606018
C410733 scriptaid scriptaid affects the expression of EIF4G2 mRNAaffects expression 18813790
D020123 Sirolimus Sirolimus results in increased expression of EIF4G2 proteinincreases expression 18491231
C017947 sodium arsenite sodium arsenite results in decreased expression of EIF4G2 mRNAdecreases expression 20308225
D018038 Sodium Selenite Sodium Selenite results in increased expression of EIF4G2 mRNAincreases expression 18175754
C517826 tetrabrominated diphenyl ether 47 tetrabrominated diphenyl ether 47 results in increased expression of EIF4G2 mRNAincreases expression 20056577
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of EIF4G2 mRNAincreases expression 19465110
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of EIF4G2 proteinincreases expression 18491231
D014212 Tretinoin PDCD4 protein promotes the reaction [Tretinoin results in increased expression of EIF4G2 protein]increases expression|increases reaction 17259349
D014212 Tretinoin Tretinoin results in increased expression of and results in increased localization of EIF4G2 proteinincreases expression|increases localization 18491231
D014212 Tretinoin Tretinoin results in increased expression of EIF4G2 mRNAincreases expression 18491231
C012589 trichostatin A trichostatin A results in decreased expression of EIF4G2 mRNAdecreases expression 19606018
C025643 vinclozolin vinclozolin affects the expression of EIF4G2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7415322242 14514962 11752688
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3019825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 4.3011473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.693712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5915276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8017306315 16712894
MESH:D000505 Alopecia Tretinoin 3.5315955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D000741 Anemia, Aplastic Benzene 4.2814761424 11369114 17661222
MESH:D001008 Anxiety Disorders vinclozolin 3.5519015723
MESH:D001169 Arthritis, Experimental Tretinoin 3.0116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2416292516
MESH:D001249 Asthma Tretinoin 2.3116456186
MESH:D001321 Autistic Disorder Sirolimus 3.0121115397
MESH:D001321 Autistic Disorder tetrabrominated diphenyl ether 47 3.0119211157
MESH:D001471 Barrett Esophagus Tretinoin 4.2916935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.911440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.7516206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.7512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.7516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6915746008
MESH:D001855 Bone Marrow Diseases Benzene 5.1216183116
MESH:D001943 Breast Neoplasms Benzene 2.3111921183 17162533
MESH:D001943 Breast Neoplasms Calcitriol 2.3111237771
MESH:D001943 Breast Neoplasms Estradiol 2.3117289903 17261762 12948864 14630087 19861407 17018787 18497071 16675129
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3120435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3116873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4816813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2211589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0516168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.8316705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.837296757 3581430
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.8314691202 11135700 16217749 15553829 15073043
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.8316924424
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 13.8319335982
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.8315276417 16507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.831917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7719014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.627296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0212490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 14.0411237771
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 14.0419435901
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 14.0418572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 14.0418922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.0416096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3118850075 18670907 16120746
MESH:D002386 Cataract Tretinoin 3.0317460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.406135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.407505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.4018566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.4019524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.069022650 19486331
MESH:D002822 Choriocarcinoma Tretinoin 5.0516461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6415894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.618697196 12621046 16354765 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 5.619407595
MESH:D003092 Colitis Tretinoin 3.6017035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9614669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.3310525206
MESH:D019465 Craniofacial Abnormalities Benzene 5.3315643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.3310048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.339224671 8800419 9125849 16925845 9664655 10589399 9211117 17551590 14991402 9142499
MESH:D003456 Cryptorchidism vinclozolin 4.2314966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9118551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9915213294
MESH:D003872 Dermatitis Benzene 4.6615902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7018759878 11906362 8156756 2524372 12868966 11298694 8970840 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.392952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6816285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3219279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.7021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.7018692083 9653073 9328219 1440618 18289764 16192314 11289319 18648102 9022650 7440962 6482804 8291058 6679447
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 8.7015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.7020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6211000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 6.629599246 15177302 7812673 16716910 8273558 11698051 8113982
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.5918230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 11.5918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.8315138306
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 5.5319294695
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 6.4620641076
MESH:D016889 Endometrial Neoplasms Estradiol 7.1719148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 7.1716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9210568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.383581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.3812903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.5611564622
MESH:D005124 Eye Abnormalities Tretinoin 8.5616938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 3.1915073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.2620067830
MESH:D005355 Fibrosis Tretinoin 8.2617994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1516904648
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1916417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5716452187
MESH:D005909 Glioblastoma Tretinoin 7.1817312396
MESH:D005909 Glioblastoma trichostatin A 7.1818801729
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006258 Head and Neck Neoplasms Sirolimus 7.9419435901
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.9416096774
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 5.0720641076
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0516084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3411294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.349664655 14991402
MESH:D006402 Hematologic Diseases Benzene 4.5516183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.416705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7815340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.9315709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.0612676792
MESH:D019584 Hot Flashes Estradiol 3.6517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.948697196 16354765 16959395 18606429 15340226
MESH:D006930 Hyperalgesia Tretinoin 3.1216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4616778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8315034207
MESH:D006973 Hypertension Benzene 5.1717940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718670907 18850075
MESH:D006984 Hypertrophy Sirolimus 5.1319211884
MESH:D007248 Infertility, Male sodium arsenite 6.6012646999 15346721
MESH:D007248 Infertility, Male vinclozolin 6.6016467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9712878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 4.977562506 7812673 11698051 8273558 15177302
MESH:D007333 Insulin Resistance Estradiol 7.1916393666 16627594
MESH:D007333 Insulin Resistance Sodium Selenite 7.1914714311
MESH:D007410 Intestinal Diseases Tretinoin 3.6617994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.919022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.5916580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.5915992940 17551590
MESH:D007674 Kidney Diseases Estradiol 5.9015618244
MESH:D007674 Kidney Diseases sodium arsenite 5.9020008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.8716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.876582329
MESH:D007680 Kidney Neoplasms Estradiol 11.8715610895
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 14.5812970779
MESH:D007938 Leukemia arsenic trioxide 14.5815070760
MESH:D007938 Leukemia Benzene 14.5815935818 14694614 17119257 18335105
MESH:D007938 Leukemia Tretinoin 14.5817143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6912560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 15.4519077051
MESH:D007951 Leukemia, Myeloid Benzene 15.4517506065
MESH:D007951 Leukemia, Myeloid Tretinoin 15.4516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 8.6516467208 16968895 19850784 17050201 20471514
MESH:D015470 Leukemia, Myeloid, Acute Benzene 8.6519478238
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 8.6516294345 19850784 17596541
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 8.6518206229
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.3916966277 17712046 12679006 19075265 17869043 16112521 15336539 11468182 15213294 19642359 16330433 16823087 16891316 17107899 15622746 12712474 17217047 15748426 12018890 9834237 19225113 16331271 11161223 19035177 17649720
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.3917217047 16331271 19035177 19225113 16140955 17506722 16823087 15748426 17294898 17368321 17649720 16788101 17339181 19075265 16891316 12679006 9834237 16766008 19642359 17301526 17712046 19029980 17361223 16935935 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2416882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6216417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.239224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 6.6311682029
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.6314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 6.6317050028
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.6316248980 18397230
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.367678174
MESH:D008113 Liver Neoplasms arsenic trioxide 10.3614682389
MESH:D008113 Liver Neoplasms sodium arsenite 10.3616712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.3616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 17.922876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.92598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 17.9220377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 17.9212562636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.9212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2615213294
MESH:D008171 Lung Diseases sodium arsenite 3.1019095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.7014698565
MESH:D008175 Lung Neoplasms arsenic trioxide 6.4719825857 11798837
MESH:D008175 Lung Neoplasms Benzene 6.4712562636
MESH:D008175 Lung Neoplasms sodium arsenite 6.4719931552 17306315 15276417 16712894 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4719555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 6.4711807781
MESH:D008223 Lymphoma Benzene 3.6617584886 17119257
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9514737004
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.3312562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 9.7211921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.7211408345 17203775 11807958 16891317
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 9.728985016
MESH:D020149 Manganese Poisoning Estradiol 4.3819453300
MESH:D008527 Medulloblastoma Tretinoin 2.7417453147
MESH:D008545 Melanoma Sirolimus 7.2319282848
MESH:D008545 Melanoma sodium arsenite 7.2319082730 16487513
MESH:D008545 Melanoma Tretinoin 7.2316752155
MESH:D008545 Melanoma trichostatin A 7.2316505122
MESH:D008591 Meningomyelocele Tretinoin 4.3216940565
MESH:D009062 Mouth Neoplasms Sirolimus 4.6219435901
MESH:D009101 Multiple Myeloma arsenic trioxide 11.8219549372 19417148 11468182 14977855 15949261
MESH:D009101 Multiple Myeloma Benzene 11.8217119195
MESH:D009101 Multiple Myeloma trichostatin A 11.8218172295
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.1816105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.1817596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1916810080
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.7518551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8516624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.433581430
MESH:D009369 Neoplasms sodium arsenite 4.9311559025
MESH:D009369 Neoplasms Tretinoin 4.9316946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5620056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6217289903
MESH:D009421 Nervous System Malformations Estradiol 15.7116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.7114600291
MESH:D009421 Nervous System Malformations Tretinoin 15.719125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 22.006679447
MESH:D009436 Neural Tube Defects arsenic trioxide 22.0010525206
MESH:D009436 Neural Tube Defects Benzene 22.0015643154
MESH:D009436 Neural Tube Defects sodium arsenite 22.0012854658
MESH:D009436 Neural Tube Defects Tretinoin 22.009142499
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.6016049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.606482804 4026338
MESH:D009784 Occupational Diseases Benzene 14.6017178637 15727169 15576619 16737584 17119257 15913788 17479406 15612468 15935809
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 22.4316211241
MESH:D010051 Ovarian Neoplasms arsenic trioxide 22.4316624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Benzene 22.4312562636
MESH:D010051 Ovarian Neoplasms Estradiol 22.4319401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 22.4317306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 22.4316936753
MESH:D010051 Ovarian Neoplasms trichostatin A 22.4319331143
MESH:D010146 Pain Tretinoin 2.8116870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.0815580305
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 12.0815976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 12.0815976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 12.0819294695
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 9.037296757
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 9.038330346 12065085 18922899 18404319
MESH:D010235 Paraganglioma arsenic trioxide 4.0619927285
MESH:D010300 Parkinson Disease Sirolimus 3.7019682553
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.366228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.1311118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.1319015723 18220299 18042343
MESH:D055728 Primary Myelofibrosis trichostatin A 5.1417616702
MESH:D011469 Prostatic Diseases vinclozolin 4.8318220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0919131511
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0915754350 12479363 18247401 16644109 16289102
MESH:D011471 Prostatic Neoplasms Estradiol 2.0916740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.0916205645
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0916039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.0918760546
MESH:D011471 Prostatic Neoplasms trichostatin A 2.0919789329 18798265
MESH:D011472 Prostatitis vinclozolin 4.8318629315
MESH:D011507 Proteinuria Tretinoin 3.5016636307
MESH:D011625 Pterygium Tretinoin 4.6816723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.293692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9916283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8516646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4618551238
MESH:D012878 Skin Neoplasms sodium arsenite 13.1718572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.1716192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 13.1718404319 12065085 8330346 11807781 8985016
MESH:D012878 Skin Neoplasms Tretinoin 13.1716467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7112854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4017007042
MESH:D013274 Stomach Neoplasms Benzene 3.4012562636
MESH:D013274 Stomach Neoplasms Tretinoin 3.4017261132
MESH:D013953 Thymus Neoplasms Benzene 4.8510850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.471399818 3712494 6587162 6582329 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.4719014326
MESH:D013964 Thyroid Neoplasms Tretinoin 11.4717045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.5819048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.6916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8515213294
MESH:D014376 Tuberculosis Tretinoin 3.1616040207
MESH:D014402 Tuberous Sclerosis Sirolimus 5.4621115397 18495876
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.5816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.588074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.5812973940 12845720 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.5817306315 11723127 16452187 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2110091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.0811813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.0816129372
MESH:D014594 Uterine Neoplasms Benzene 4.2312562636
MESH:D014604 Uveal Neoplasms Tretinoin 4.5016752155
MESH:D014605 Uveitis Sirolimus 5.531336536
MESH:D014652 Vascular Diseases sodium arsenite 4.3217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D014820 Vitiligo Tretinoin 3.9516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D009396 Wilms Tumor Tretinoin 3.8716287080
Pathway ID Pathway Name
KEGG:03013 RNA transport
KEGG:05416 Viral myocarditis
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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