AutismKB 2.0

Annotation Detail for EIF5


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Basic Information Top
Gene Symbol:EIF5 ( EIF-5A )
Gene Full Name: eukaryotic translation initiation factor 5
Band: 14q32.32
Quick LinksEntrez ID:1983; OMIM: 601710; Uniprot ID:IF5_HUMAN; ENSEMBL ID: ENSG00000100664; HGNC ID: 3299
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Metabolism of proteins
Gene Expression
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No data
Pathway IDPathway Name
500901Cap-dependent Translation Initiation
500944Ribosomal scanning and start codon recognition
500970GTP hydrolysis and joining of the 60S ribosomal subunit
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of EIF5 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of EIF5 mRNAdecreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of EIF5 mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of EIF5 mRNAdecreases expression 16514628
D000082 Acetaminophen Acetaminophen affects the expression of EIF5 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of EIF5 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of EIF5 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of EIF5 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of EIF5 mRNAincreases expression 20064835
C004541 biochanin A biochanin A results in decreased expression of EIF5 mRNAdecreases expression 12111696
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of EIF5 mRNAincreases expression 15336504
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of EIF5 mRNAaffects cotreatment|decreases expression 18636392
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of EIF5 mRNAaffects cotreatment|decreases expression 19684285
D016572 Cyclosporine Cyclosporine results in increased expression of EIF5 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of EIF5 mRNAincreases expression 16514628
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of EIF5 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of EIF5 mRNAincreases expression 16174780
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF5 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of EIF5 mRNAincreases expression 16174780
D005419 Flavonoids Flavonoids results in increased expression of EIF5 mRNAincreases expression 18035473
D005472 Fluorouracil Fluorouracil results in increased expression of EIF5 mRNAincreases expression 17039268
C070081 fulvestrant fulvestrant results in decreased expression of EIF5 mRNAdecreases expression 16514628
D007657 Ketone Bodies Ketone Bodies results in increased expression of EIF5 mRNAincreases expression 16807920
D001556 Lindane Lindane results in increased expression of EIF5 mRNAincreases expression 17785943
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in decreased expression of EIF5 mRNAdecreases expression 12634122
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of EIF5 mRNAincreases expression 17616710
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of EIF5 mRNAaffects cotreatment|decreases expression 18636392
C006253 pirinixic acid pirinixic acid results in increased expression of EIF5 mRNAincreases expression 18301758
D011374 Progesterone Progesterone results in increased expression of EIF5 mRNAincreases expression 18037150
D020849 Raloxifene Raloxifene results in decreased expression of EIF5 mRNAdecreases expression 16514628
C017947 sodium arsenite sodium arsenite results in increased expression of EIF5 mRNAincreases expression 16014739
D013629 Tamoxifen Tamoxifen affects the expression of EIF5 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of EIF5 mRNAaffects cotreatment|decreases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of EIF5 mRNAdecreases expression 19684285
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF5 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of EIF5 mRNAdecreases expression 11752688
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of EIF5 mRNAaffects cotreatment|affects expression 16979875
D014415 Tunicamycin Tunicamycin results in increased expression of EIF5 mRNAincreases expression 17127020
C025643 vinclozolin vinclozolin affects the expression of EIF5 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of EIF5 mRNAdecreases expression 19244175
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of EIF5 mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2014745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5115322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6017505938
MESH:D000169 Acrodermatitis Zinc 5.0617190629 17202136 16889938
MESH:D055371 Acute Lung Injury Chlorine 8.1120601635
MESH:D055371 Acute Lung Injury pirinixic acid 8.1118653653
MESH:D000230 Adenocarcinoma arsenic trioxide 12.5211798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.5220127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 12.5211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.5214692618
MESH:D000230 Adenocarcinoma Fluorouracil 12.5217638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.466695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.7716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.7716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5616712894 17306315
MESH:D000382 Agricultural Workers' Diseases Lindane 4.0412661182
MESH:D000419 Albuminuria Raloxifene 4.2717451421 17308373
MESH:D000544 Alzheimer Disease Ozone 6.2415513908
MESH:D000544 Alzheimer Disease Raloxifene 6.2415800139
MESH:D000544 Alzheimer Disease Zinc 6.2416580781 17119284 16410023 16325427
MESH:D000740 Anemia Fluorouracil 7.7117963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.7111748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.5816916123
MESH:D000799 Angioedema Acetaminophen 3.5010982225
MESH:D001008 Anxiety Disorders vinclozolin 3.3719015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7419183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5120041841 18218290 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4515885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4815570426
MESH:D001249 Asthma Ozone 4.8017854713 16373670
MESH:D001249 Asthma Zinc 4.8017085522
MESH:D001281 Atrial Fibrillation Amiodarone 3.6518651412 19698954
MESH:D001284 Atrophy fulvestrant 4.5211514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 19.4719483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 19.4716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 19.4719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 19.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5515746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9917868700
MESH:D001930 Brain Injuries Progesterone 16.5315665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 16.5316580743
MESH:D001930 Brain Injuries Zinc 16.5317109824
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.4620146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 5.4612948864 17261762 17018787 19861407 16675129 17289903 18497071 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 5.4616110121 16595493 18357371 15136595 19217205 18608205 16557594
MESH:D001943 Breast Neoplasms fulvestrant 5.4618984771
MESH:D001943 Breast Neoplasms Lindane 5.4614688026
MESH:D001943 Breast Neoplasms Progesterone 5.4617614352 15562024 16175315
MESH:D001943 Breast Neoplasms Raloxifene 5.4616837676 15758505 17595753 17893378 17049068 16912660 17440819 15572757 17952589 17242785 17261762 15775269
MESH:D001943 Breast Neoplasms Tamoxifen 5.4619487384 15668708 20390343 19142967 19115204 16818667 17049068 20135344 21138602 18821012 19410462 18997820 17261762 15565566 18984771 20065188 16273361 20544844 20005174 19011961 17242785 19066611 17440819 18351453 18425577 19244106 20859285 17893378 19289846 19084267 19288272 19189212 19059307 18815881 21152245 19221464 19103187 19155303 19200415 18629630 16873071 11161223 18855134 16202921 19189210
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.4620435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4118417511 15516495 18315731 16777450 19059883 14754758 17626835
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0211589617
MESH:D002100 Cachexia Ozone 4.4016183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1216111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.6016050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3216051944
MESH:D002277 Carcinoma Fluorouracil 7.3017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.3016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1719066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 15.8316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 15.8316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.833084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 15.8316217749 15553829 14691202 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.8316924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 15.8317088986 17045692 18930000 16332177 17971768 16799960
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 15.8316507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 15.8316924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5319014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8618695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 13.2020419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 13.2016757204 18986760 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 13.2018572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 13.2018922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 13.2016543248
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.5217572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.5217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1818850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7715710769 19225199
MESH:D002318 Cardiovascular Diseases Raloxifene 6.8515775269
MESH:D002318 Cardiovascular Diseases Zinc 6.8516936243
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7418974383
MESH:D002386 Cataract Acetaminophen 2.3810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 18.636135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 18.6312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.6318566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 18.632727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 18.6319524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8816835633
MESH:D002779 Cholestasis Cyclosporine 11.8919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.8917681005 15861022 16919318 17110522 16105132 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 11.8919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9612621046 8697196 16354765 15668235 15340226
MESH:D003072 Cognition Disorders Raloxifene 4.2915800139
MESH:D003110 Colonic Neoplasms Fluorouracil 2.1815001691 17169374 17725105 17016597 16510598 18772588 17287894 17018589 17172411 16340194
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.4620501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.4620501625 17016601 16282729 18448328 17695437 14970324 15148649 16391804 18383874 17255274 16524972 17094418 18802399 15289873 18509181 17401013 16303861 18288408 17454858 16331619 18949393 17594712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7817141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.0810525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.0820055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.0819769572
MESH:D019465 Craniofacial Abnormalities Zinc 5.0819302082
MESH:D003456 Cryptorchidism vinclozolin 4.0214966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.7918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.7918551238
MESH:D007644 Darier Disease Fluorouracil 4.4516733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7815213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0319031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8817474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003920 Diabetes Mellitus Zinc 3.9216479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5817107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.3819279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.3817308373 15920148 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.3819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1617187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 10.8321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 10.8321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 10.8319420014 11739529 19085960 14725611 16227642 11743745 17906064 11529661 19416960 16781746 11421492 12705907 11834606 18713872 10915739 12392966 11287661 12153990 18071297 15619225 16109766 2444490 12594235 14550746 12958197 19923254 11461765 10663392 16081117 16485898 17522070 19370779 19739265 17562736 14986274 16393943 19164858 10774834 16177239 12540782 15968718
MESH:D056486 Drug-Induced Liver Injury Amiodarone 10.8318218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.8320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5111462148
MESH:D004417 Dyspnea Chlorine 4.2820016425
MESH:C538011 Eales disease Vitamin E 4.369068938
MESH:D004487 Edema pirinixic acid 13.9912083418
MESH:D004487 Edema Raloxifene 13.9915860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.9911000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 13.999599246 8273558 8113982 11698051 7812673 16716910 15177302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5618230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 19.2712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 19.2717692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 19.2715845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 19.2719031437
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 11.2719148513
MESH:D016889 Endometrial Neoplasms Estradiol 11.2711473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.2719155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Progesterone 7.9516134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.9510568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 12.8112903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.8116530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 12.8115173087 16785472 16337965 16481741 17638652
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 12.8116805852 15264214 15150132 15878914 15547733 15547721 15623463 16510608 16704527
MESH:D004938 Esophageal Neoplasms Zinc 12.8116543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7611564622
MESH:D005234 Fatty Liver Amiodarone 32.3114986274
MESH:D005234 Fatty Liver arsenic trioxide 32.3115073043
MESH:D005234 Fatty Liver Cyclosporine 32.3119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 32.3115345470
MESH:D005234 Fatty Liver pirinixic acid 32.3120131406 19236843
MESH:D005234 Fatty Liver Raloxifene 32.3117473493
MESH:D005234 Fatty Liver Tamoxifen 32.3119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1211858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8419069698
MESH:D005355 Fibrosis Cyclosporine 7.3812639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.3820067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9416904648
MESH:D005739 Gas Poisoning Chlorine 4.6620016425
MESH:D005756 Gastritis Acetaminophen 10.0116983495
MESH:D005756 Gastritis Zinc 10.0117241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5916973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9516417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.888708960
MESH:D005909 Glioblastoma biochanin A 4.2416598420
MESH:D005910 Glioma Fluorouracil 2.7316145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2510696789
MESH:D006130 Growth Disorders Zinc 3.7417217573
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.1618337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.0420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.0411294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 10.0416080930
MESH:D006331 Heart Diseases Raloxifene 3.3011110106
MESH:D006333 Heart Failure pirinixic acid 6.4520558911
MESH:D006333 Heart Failure Zinc 6.4517162251
MESH:D006335 Heart Injuries Zinc 5.4217074742
MESH:D016481 Helicobacter Infections Zinc 4.2217241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0311000095
MESH:D006527 Hepatolenticular Degeneration Zinc 4.3617276780
MESH:D006529 Hepatomegaly Amiodarone 12.4915265979
MESH:D006529 Hepatomegaly pirinixic acid 12.4919176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.4916120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5816863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.6915709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.8812676792
MESH:D019584 Hot Flashes Estradiol 8.9017088409
MESH:D019584 Hot Flashes Vitamin E 8.9014716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7016959395 18606429 16354765 8697196 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.4416870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.578137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 2.8920558911
MESH:D006973 Hypertension Cyclosporine 7.7910903974
MESH:D006973 Hypertension Raloxifene 7.7917577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.7918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4816569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 4.1818020914 17991464
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0715869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 14.2117937319
MESH:D007248 Infertility, Male fulvestrant 14.2111514358
MESH:D007248 Infertility, Male sodium arsenite 14.2112646999 15346721
MESH:D007248 Infertility, Male vinclozolin 14.2116467254
MESH:D007249 Inflammation Flavonoids 13.9517296493
MESH:D007249 Inflammation Progesterone 13.9515869954
MESH:D007249 Inflammation Tamoxifen 13.9519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.9512200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 13.9515177302 11698051 8273558 7812673 7562506
MESH:D007251 Influenza, Human Vitamin E 3.8716624496
MESH:D007333 Insulin Resistance Estradiol 6.4616627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.4616306350
MESH:D007511 Ischemia Zinc 4.3016584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0915604871
MESH:D007674 Kidney Diseases Acetaminophen 21.2912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 21.2910903974 8314463 18776723
MESH:D007674 Kidney Diseases Estradiol 21.2915618244
MESH:D007674 Kidney Diseases sodium arsenite 21.2920008137
MESH:D007674 Kidney Diseases Vitamin E 21.2912488133
MESH:D007674 Kidney Diseases Zinc 21.2916960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.1216518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 25.5416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 25.5416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 25.5412371664
MESH:D007680 Kidney Neoplasms Estradiol 25.5415610895
MESH:D007680 Kidney Neoplasms Fluorouracil 25.5416985049
MESH:D007680 Kidney Neoplasms Tamoxifen 25.5418625569
MESH:D007889 Leiomyoma Raloxifene 4.1816973256
MESH:D007938 Leukemia arsenic trioxide 2.6615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4912560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.4619077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.0820471514 19850784 16467208 17050201 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 2.9916966277 12712474 15622746 17649720 19225113 17217047 12018890 16891316 15748426 9834237 16331271 11468182 15336539 19035177 16330433 15213294 12679006 17712046 19075265 16112521 11161223 16823087 17869043 19642359 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0316882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3916417039
MESH:D008064 Lipidoses Amiodarone 7.1115342952 17567588
MESH:D008064 Lipidoses Tamoxifen 7.1117567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.2114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.2115474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.2118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.2112878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.2116169303
MESH:D008107 Liver Diseases Acetaminophen 3.9616610002 12969438 12587719 19784758 16611625 19014921 11587558 19460945
MESH:D008107 Liver Diseases Lindane 3.961715830
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 23.577678174
MESH:D008113 Liver Neoplasms arsenic trioxide 23.5714682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 23.5720195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 23.5717045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 23.5720007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 23.5716712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 23.5716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 23.5716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 8.566135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 8.5620377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.5612151625
MESH:D008133 Long QT Syndrome Amiodarone 7.3415350150 11989578 17391786
MESH:D008133 Long QT Syndrome arsenic trioxide 7.3415213294
MESH:D008171 Lung Diseases Amiodarone 15.7312587719
MESH:D008171 Lung Diseases Ozone 15.738266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 15.7319095001
MESH:D008171 Lung Diseases Vitamin E 15.7316863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1318516814
MESH:D055370 Lung Injury Ozone 3.5220417186
MESH:D008175 Lung Neoplasms arsenic trioxide 14.4719825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.4720064080 18520028 6695378 20464547 20135361 18816296 17053015 18569708 20869020
MESH:D008175 Lung Neoplasms Fluorouracil 14.4715246190
MESH:D008175 Lung Neoplasms Ozone 14.477614698 8597069
MESH:D008175 Lung Neoplasms sodium arsenite 14.4715276417 16712894 19931552 17306315 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 14.4718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.4711884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 14.4711807781
MESH:D008175 Lung Neoplasms Vitamin E 14.4711062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4515086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4219428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 16.5111408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 16.5111408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 16.5111731420 19196722 14580682 19196723 16827153
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 16.518985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 16.5112773700
MESH:D020149 Manganese Poisoning Estradiol 11.4919453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.4919453300
MESH:D008545 Melanoma sodium arsenite 3.1119082730 16487513
MESH:D008545 Melanoma Tamoxifen 3.1112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4416801185
MESH:D008679 Metaplasia Ozone 4.7610496685
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.5517671175
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2115863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.6716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.6716757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 6.6119549372 11468182 15949261 19417148 14977855
MESH:D009101 Multiple Myeloma Raloxifene 6.6116497877
MESH:D009135 Muscular Diseases pirinixic acid 3.1716239165
MESH:D009181 Mycoses Amiodarone 4.5612754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.9516882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.0019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.3916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.3916411023
MESH:D009232 Myxoma Raloxifene 5.2116343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.2118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.217678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6416624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 13.9011141357
MESH:D009369 Neoplasms Fluorouracil 13.9016928823 18600527 18239605
MESH:D009369 Neoplasms Lindane 13.9012807735 16818664
MESH:D009369 Neoplasms pirinixic acid 13.9017405874
MESH:D009369 Neoplasms sodium arsenite 13.9011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3420056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6519196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0018481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 8.3911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.3914600291
MESH:D009436 Neural Tube Defects arsenic trioxide 6.6010525206
MESH:D009436 Neural Tube Defects sodium arsenite 6.6012854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6018514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2116436463
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.9112819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.9116049721
MESH:D010024 Osteoporosis Raloxifene 3.1917882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.9217823083 15758505 17893378 15579764
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.3516624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 10.3519401270
MESH:D010051 Ovarian Neoplasms Progesterone 10.3517393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.3517306315 15276417
MESH:D010146 Pain Acetaminophen 2.1316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 7.9815580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 7.9819003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 7.9815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3711578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.9618922899 12065085 8330346 18404319
MESH:D010235 Paraganglioma arsenic trioxide 3.8519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9012520081
MESH:D010538 Peritonitis Ozone 3.8016369182
MESH:D011014 Pneumonia Ozone 4.0518381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2418163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9412371664
MESH:D011225 Pre-Eclampsia Zinc 3.9217114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.3611118676 11896295 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.3618042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.5918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 4.0619131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 4.0617292933
MESH:D011471 Prostatic Neoplasms biochanin A 4.0612111696
MESH:D011471 Prostatic Neoplasms Estradiol 4.0616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 4.0619082440 18626508
MESH:D011471 Prostatic Neoplasms Lindane 4.0614688026 12661182
MESH:D011471 Prostatic Neoplasms Raloxifene 4.0615731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms sodium arsenite 4.0616039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 4.0615067354
MESH:D011471 Prostatic Neoplasms Vitamin E 4.0615084515
MESH:D011471 Prostatic Neoplasms Zinc 4.0616700911 12429649 16606632 16517595
MESH:D011472 Prostatitis vinclozolin 4.5918629315
MESH:D011537 Pruritus Ethinyl Estradiol 2.9816919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1116882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7211597910 12490602 12832656
MESH:D011693 Purpura Raloxifene 5.2115770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7318722050 15538739 16160472 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.2219058328
MESH:D012120 Respiration Disorders Chlorine 4.8718579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5118990726
MESH:D012162 Retinal Degeneration Zinc 3.8816584753
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7318045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6416646077
MESH:D012640 Seizures 2,4-dinitrotoluene 8.6018551238
MESH:D012640 Seizures 2,6-dinitrotoluene 8.6018551238
MESH:D012640 Seizures Lindane 8.607539098 15475178 12842176
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7418724381
MESH:D012871 Skin Diseases Vitamin E 2.3518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 16.1719755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 16.1719524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 16.178532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.1716192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 16.1718404319 12065085 11807781 8985016 8330346
MESH:D013088 Spermatocele Ethinyl Estradiol 10.4116709447
MESH:D013088 Spermatocele Tamoxifen 10.4116709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.7416503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.7419457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5412854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.4317007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.432093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 4.4316424979 16951190 18396642 19015929 17522103 19084572 18567086 17172411 15786421 17498489
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.4312958204 17575124
MESH:D013276 Stomach Ulcer Amiodarone 3.0218087811
MESH:D020521 Stroke Raloxifene 7.8316837676
MESH:D020521 Stroke Vitamin E 7.8316517955
MESH:D013610 Tachycardia Amiodarone 3.9711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8719225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8715669648
MESH:D013959 Thyroid Diseases Amiodarone 10.9019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.9012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 2.8419014326
MESH:D013971 Thyrotoxicosis Amiodarone 4.5319584973 18020914
MESH:D013978 Tibial Fractures Estradiol 12.5619048282
MESH:D013978 Tibial Fractures Raloxifene 12.5619048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.0816280240
MESH:D014062 Tongue Neoplasms Zinc 9.0816543248
MESH:D016171 Torsades de Pointes Amiodarone 9.1311989578 17467628
MESH:D016171 Torsades de Pointes arsenic trioxide 9.1315213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 21.9916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 21.9916049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 21.9911780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 21.9917053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 21.9917572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 21.9916712894 16452187 17306315 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 21.9916712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.8510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.8510091137
MESH:D014581 Urticaria Acetaminophen 2.6710982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.5116803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.5111813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9814692618
MESH:D014605 Uveitis Cyclosporine 3.641336536
MESH:D014652 Vascular Diseases sodium arsenite 4.0817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2512125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8616837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2414671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2116343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.0917120751
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:17015 Metabolism of proteins
KEGG:03013 RNA transport
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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