AutismKB 2.0

Annotation Detail for AIF1


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Basic Information Top
Gene Symbol:AIF1 ( AIF-1,IBA1,IRT-1,IRT1 )
Gene Full Name: allograft inflammatory factor 1
Band: 6p21.33
Quick LinksEntrez ID:199; OMIM: 601833; Uniprot ID:AIF1_HUMAN; ENSEMBL ID: ENSG00000204472; HGNC ID: 352
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1818Systemic scleroderma
1918Atherosclerosis
1971Hemangioma
2032Kidney disease
2068Skin disease
2089Creutzfeldt-Jakob syndrome
Desease Name
sclerosis, systemic
IMMUNE
weight
METABOLIC
Desease Name
Weight
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C019499 2-nitrofluorene 2-nitrofluorene results in increased expression of AIF1 mRNAincreases expression 14600272
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of AIF1 mRNAincreases expression 14600272
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AIF1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of AIF1 mRNAdecreases expression 19128835
D001554 Benzene Benzene affects the expression of AIF1 mRNAaffects expression 15878777
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of AIF1 mRNAincreases expression 14600272
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of AIF1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of AIF1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AIF1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of AIF1 mRNAincreases expression 17351261
D005419 Flavonoids Flavonoids results in decreased expression of AIF1 mRNAdecreases expression 18035473
D006581 Hexachlorobenzene Hexachlorobenzene affects the expression of AIF1 mRNAaffects expression 15159207
D009151 Mustard Gas Mustard Gas results in increased expression of AIF1 mRNAincreases expression 18988085
D009173 Mycophenolic Acid Mycophenolic Acid results in decreased expression of AIF1 mRNAdecreases expression 10688038
D009173 Mycophenolic Acid [Quercetin co-treated with Mycophenolic Acid] results in decreased expression of AIF1 mRNAaffects cotreatment|decreases expression 10688038
D011794 Quercetin [Quercetin co-treated with Mycophenolic Acid] results in decreased expression of AIF1 mRNAaffects cotreatment|decreases expression 10688038
D011794 Quercetin Quercetin results in decreased expression of AIF1 mRNAdecreases expression 10688038
C037219 quinoline quinoline analog results in increased activity of AIF1 proteinincreases activity 18645022
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of AIF1 mRNAdecreases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of AIF1 mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AIF1 mRNAaffects cotreatment|increases expression 17942748
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of AIF1 mRNAdecreases expression 17951470
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9011752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D000230 Adenocarcinoma arsenic trioxide 7.1919825857 11798837
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 7.1916033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1914692618
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 7.3916176798
MESH:D000236 Adenoma Dimethylnitrosamine 7.3919555203
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000741 Anemia, Aplastic Benzene 4.3911369114 14761424 17661222
MESH:D000743 Anemia, Hemolytic Quercetin 4.2717084956
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001249 Asthma Mustard Gas 2.7210378619
MESH:D001260 Ataxia Telangiectasia Quercetin 5.0315336622
MESH:D001327 Autoimmune Diseases Quercetin 4.4519761891
MESH:D001768 Blister Mustard Gas 5.2119167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.0616206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001855 Bone Marrow Diseases Benzene 5.2916183116
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 2.3920146248
MESH:D001943 Breast Neoplasms Benzene 2.3911921183 17162533
MESH:D001943 Breast Neoplasms Hexachlorobenzene 2.3915061365 12709520
MESH:D001943 Breast Neoplasms Quercetin 2.3918628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3920435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0410378619 17687719
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3611589617
MESH:D002105 Cadmium Poisoning Quercetin 5.6116962696
MESH:D002277 Carcinoma Dimethylnitrosamine 8.4319555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4316835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8914691202 16217749 15553829 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.8919519916 12508355
MESH:D006528 Carcinoma, Hepatocellular quinoline 4.89598648
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0017234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1412490120
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 2.9616033868
MESH:D006332 Cardiomegaly Quercetin 6.8519794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.8516120746 18850075 18670907
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8917681005 17333356 16919318 17110522 11677210 15861022 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1116354765 8697196 15668235 15340226 12621046
MESH:D003110 Colonic Neoplasms Quercetin 2.4217191121 16640504 17148506 19440933 11134977 19056647 15741050
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6220501625
MESH:D015179 Colorectal Neoplasms Quercetin 2.6218095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0814669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8610525206
MESH:D019465 Craniofacial Abnormalities Benzene 3.8615643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8615322242 20055451 10048152
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1315213294
MESH:D003872 Dermatitis Benzene 4.8115902427
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.7519496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 4.018172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004487 Edema Mustard Gas 6.9411428631 9260866 11428647 11402378
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9616714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D004890 Erythema Mustard Gas 5.219357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7912903497
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 4.7917016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver arsenic trioxide 7.8315073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.8315345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis Quercetin 8.9019474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9020067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3016904648
MESH:D005909 Glioblastoma Quercetin 3.4119804834
MESH:D005910 Glioma Quercetin 3.0617643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3411294989 10048152
MESH:D006390 Hemangioendothelioma quinoline 5.97598648
MESH:D006394 Hemangiosarcoma quinoline 5.02598648
MESH:D006402 Hematologic Diseases Benzene 4.6916183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9312621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1116959395 18606429 8697196 15340226 16354765
MESH:D006943 Hyperglycemia Quercetin 4.0618262572 11834736
MESH:D006973 Hypertension Benzene 8.7717940673
MESH:D006973 Hypertension Quercetin 8.7718356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.7718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5017937319
MESH:D007249 Inflammation Flavonoids 8.4517296493
MESH:D007249 Inflammation Mustard Gas 8.459357497 11428647 11402378 16001271 11428631 11428620 8975870 9260866 17524151
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.4512200463 12878042
MESH:D007251 Influenza, Human Quercetin 4.5716624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007627 Keloid Quercetin 5.0017086741
MESH:D007674 Kidney Diseases Quercetin 3.1116962696
MESH:D007938 Leukemia arsenic trioxide 10.6815070760
MESH:D007938 Leukemia Benzene 10.6814694614 17119257 18335105 15935818
MESH:D007938 Leukemia Quercetin 10.6817468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.8019077051
MESH:D007951 Leukemia, Myeloid Benzene 9.8017506065
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.1216968895 16467208 17050201 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.1219478238
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2315622746 15336539 17869043 16331271 16330433 19642359 12018890 15748426 12679006 9834237 17649720 17217047 15213294 12712474 16823087 19035177 16112521 17712046 11161223 17107899 19075265 16966277 11468182 16891316 19225113
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3916882451
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 3.6115138612 17201889 15744066 15161499 18210741 15577212 18629640 14643895 15793283 17198567 15591649 15383259 17881167 15864749 17203207 15369754 16570917 18672772 18567088 17465448 18237412 17724770 15723089 14726149 15504291 15479170 15086199 16042886 16603200 14568256 14659978 17348192 18637143 17534399 15842777 16009107 16544323 15571005 15099470 15942678 12918455 14709902 12925901 18239293 17036385 15798949 15733078 16169303 17666798 16627068 15492853 15298665 15366600 15339415 18371158 18095165 17719030 15067225 16270385 15081153 18364076 17196135 17640959 15763062 17432682
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.6112741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6112878042
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.4317457977
MESH:D008113 Liver Neoplasms 2-nitrofluorene 18.1515890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 18.1515890375
MESH:D008113 Liver Neoplasms arsenic trioxide 18.1514682389
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 18.153113478 15890375
MESH:D008113 Liver Neoplasms Quercetin 18.1518980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.1516984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 23.6420377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 23.6412562636
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 23.641848544 15603536 6150874
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 23.641423854
MESH:D008114 Liver Neoplasms, Experimental Quercetin 23.6419519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 23.6412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3715213294
MESH:D008171 Lung Diseases Mustard Gas 3.4718702808 18161513
MESH:D017563 Lung Diseases, Interstitial Benzene 4.8714698565
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10.7814755239 18508827 9255578 15893417 19931552 18813816 15172992 16401635 17139156 16061637 12438228
MESH:D008175 Lung Neoplasms arsenic trioxide 10.7811798837 19825857
MESH:D008175 Lung Neoplasms Benzene 10.7812562636
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 10.7811884234 16061637 19555203
MESH:D008175 Lung Neoplasms Mustard Gas 10.788781369 3148597
MESH:D008175 Lung Neoplasms Quercetin 10.7816280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.7819555203 11884234
MESH:D008223 Lymphoma Benzene 3.7517584886 17119257
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.4912562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 3.3211921183
MESH:D009101 Multiple Myeloma arsenic trioxide 7.5619549372 14977855 11468182 19417148 15949261
MESH:D009101 Multiple Myeloma Benzene 7.5617119195
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1616882451 16105982
MESH:D009203 Myocardial Infarction Quercetin 3.0019595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.8119207477
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0016624393
MESH:D009362 Neoplasm Metastasis quinoline 4.05598648
MESH:D009369 Neoplasms Quercetin 2.8115185748
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.5910525206
MESH:D009436 Neural Tube Defects Benzene 7.5915643154
MESH:D020078 Neurogenic Inflammation Quercetin 4.3917929310
MESH:D009503 Neutropenia Mustard Gas 4.0016761898 7688884
MESH:D009784 Occupational Diseases Benzene 4.2117119257 15612468 17178637 16737584 17479406 15935809 15727169 15913788 15576619
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.2519495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.0716624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Benzene 8.0712562636
MESH:D010051 Ovarian Neoplasms Quercetin 8.0719005980
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 8.8612384795
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.8615580305
MESH:D010190 Pancreatic Neoplasms Quercetin 8.8616965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010235 Paraganglioma arsenic trioxide 4.1919927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D011041 Poisoning Mustard Gas 3.8315727166
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 11.239918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 11.2318163543
MESH:D011230 Precancerous Conditions Quercetin 4.0019056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.4019131511
MESH:D011471 Prostatic Neoplasms Quercetin 3.4017292933 14715546
MESH:D011537 Pruritus Ethinyl Estradiol 9.6916919318 15861022
MESH:D011537 Pruritus Mustard Gas 9.6918058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9417720292 17266442 17620002 17894541 10334151
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0016646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.6116862918
MESH:D012871 Skin Diseases Mustard Gas 2.7215451306 12880345 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0016709447
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.3312587719
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5617007042
MESH:D013274 Stomach Neoplasms Benzene 3.5612562636
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 3.5616033868
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013953 Thymus Neoplasms Benzene 5.0110850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1119014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0115213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3120435036 12845720 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.3116720314
MESH:D014594 Uterine Neoplasms Benzene 9.6912562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.6914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5715869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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