AutismKB 2.0

Annotation Detail for SERPINB1


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Basic Information Top
Gene Symbol:SERPINB1 ( EI,ELANH2,LEI,M/NEI,MNEI,PI2 )
Gene Full Name: serpin peptidase inhibitor, clade B (ovalbumin), member 1
Band: 6p25.2
Quick LinksEntrez ID:1992; OMIM: 130135; Uniprot ID:ILEU_HUMAN; ENSEMBL ID: ENSG00000021355; HGNC ID: 3311
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of SERPINB1 mRNAdecreases expression 17547211
D000965 Antimony Antimony results in decreased expression of SERPINB1 mRNAdecreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in decreased expression of SERPINB1 mRNAdecreases expression 17547211
C006632 arsenic trioxide arsenic trioxide results in increased expression of SERPINB1 mRNAincreases expression 15761015
20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SERPINB1 mRNAincreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of SERPINB1 mRNAdecreases expression 15336504
D002104 Cadmium Cadmium results in decreased expression of SERPINB1 mRNAdecreases expression 17547211
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of SERPINB1 mRNAdecreases expression 17547211
D002857 Chromium Chromium results in decreased expression of SERPINB1 mRNAdecreases expression 17547211
D002117 Calcitriol Calcitriol results in increased expression of SERPINB1 mRNAincreases expression 16847355
15951637
16002434
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of SERPINB1 mRNAdecreases expression 17547211
D008628 Mercury Mercury results in decreased expression of SERPINB1 mRNAdecreases expression 17547211
C022838 nickel chloride nickel chloride results in decreased expression of SERPINB1 mRNAdecreases expression 17547211
D011192 Potassium Dichromate Potassium Dichromate results in decreased expression of SERPINB1 mRNAdecreases expression 17547211
C037219 quinoline quinoline analog results in increased expression of SERPINB1 proteinincreases expression 18645022
C017947 sodium arsenite sodium arsenite results in decreased expression of SERPINB1 mRNAdecreases expression 12727804
D013467 Sulindac Sulindac results in increased expression of SERPINB1 mRNAincreases expression 11507085
D019772 Topotecan SERPINB1 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014212 Tretinoin Tretinoin affects the localization of SERPINB1 proteinaffects localization 16569592
D014212 Tretinoin Tretinoin results in increased expression of SERPINB1 mRNAincreases expression 17218384
16249480
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.4414745880
MESH:D058186 Acute Kidney Injury Sulindac 4.257897758
MESH:D000230 Adenocarcinoma arsenic trioxide 7.2311798837 19825857
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 7.2316033868
MESH:D000230 Adenocarcinoma Sulindac 7.2311910360
MESH:D000236 Adenoma Dimethylnitrosamine 7.1819555203
MESH:D000236 Adenoma Sulindac 7.1810223192
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.5412394442 11535846 17611924 16460482 19003578 11874996 15623613
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8517306315 16712894
MESH:D000505 Alopecia Tretinoin 3.5615955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.0416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D050197 Atherosclerosis Cadmium 3.6015687053
MESH:D001321 Autistic Disorder Mercury 2.7917497416
MESH:D001327 Autoimmune Diseases Mercury 4.8116634805
MESH:D001471 Barrett Esophagus Tretinoin 4.3416935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.9616206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.9616197459 16206674
MESH:D001913 Bowen's Disease Sulindac 5.3011207687
MESH:D001943 Breast Neoplasms Calcitriol 2.0711237771
MESH:D001943 Breast Neoplasms Chromium 2.0715986119
MESH:D001943 Breast Neoplasms Sulindac 2.0716642371
MESH:D001943 Breast Neoplasms Tretinoin 2.0716166294 16443354 16873071
MESH:D001991 Bronchitis Antimony 6.088768112
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5316813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2711589617
MESH:D002277 Carcinoma Dimethylnitrosamine 3.9719555203
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1016168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.5816217749 15073043 11135700 15553829 14691202
MESH:D006528 Carcinoma, Hepatocellular quinoline 6.58598648
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.5815276417 16507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.581917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0612490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.6911237771
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 10.6916033868
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.6918572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.6916051514 16096774
MESH:D002311 Cardiomyopathy, Dilated Antimony 6.4710334427
MESH:D002311 Cardiomyopathy, Dilated Mercury 6.4710334427
MESH:D002386 Cataract Tretinoin 3.0517460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.0620889678
MESH:D002471 Cell Transformation, Neoplastic Cadmium 11.0617332340
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.0620056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5316129372
MESH:D002822 Choriocarcinoma Tretinoin 5.1016461808
MESH:D002972 Cleft Palate Tretinoin 2.649407595
MESH:D003092 Colitis Tretinoin 3.6417035595
MESH:D003110 Colonic Neoplasms Sulindac 2.9112458338 12902858
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7820501625
MESH:D015179 Colorectal Neoplasms Sulindac 2.7810666051 18059344 11076880 11197048
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.6610525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.6614991402 17551590 9125849 10589399 9224671 8800419 9142499 16925845 9664655 9211117
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0315213294
MESH:D017449 Dermatitis, Allergic Contact Mercury 7.5316823706
MESH:D017449 Dermatitis, Allergic Contact Potassium Dichromate 7.5316823706
MESH:D003930 Diabetic Retinopathy Sulindac 5.1112861449 17621415
MESH:D004283 Dog Diseases Antimony 5.5912019027
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 2.748172417
MESH:D004489 Edema, Cardiac Tretinoin 4.4118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.8715138306
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0616569247
MESH:D004715 Endometriosis Sulindac 4.4115652904
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.3420426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.3412903497
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 10.3417016578
MESH:D004938 Esophageal Neoplasms Sulindac 10.3412235107
MESH:D005124 Eye Abnormalities Tretinoin 3.539664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 3.2315073043
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.4214745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.0719069698
MESH:D005355 Fibrosis Tretinoin 3.4517994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2016904648
MESH:D005764 Gastroesophageal Reflux Sulindac 4.9511910360
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6216452187
MESH:D005909 Glioblastoma Tretinoin 2.9617312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1016084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.869664655 14991402
MESH:D006390 Hemangioendothelioma quinoline 5.85598648
MESH:D006394 Hemangiosarcoma quinoline 4.93598648
MESH:D006689 Hodgkin Disease sodium arsenite 3.1012676792
MESH:D006930 Hyperalgesia Tretinoin 3.1616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5016778211
MESH:D007248 Infertility, Male sodium arsenite 2.9415346721 12646999
MESH:D007249 Inflammation Sulindac 3.273291741
MESH:D007410 Intestinal Diseases Tretinoin 3.7017994277
MESH:D007414 Intestinal Neoplasms Sulindac 4.5712351151 10223192 12663524 10213222 12584176 12628509
MESH:D007417 Intestinal Polyps Sulindac 4.9211245490 12394442
MESH:D007569 Jaw Abnormalities Tretinoin 3.8415992940 17551590
MESH:D007674 Kidney Diseases Cadmium 23.4116226777 16322080 16962696
MESH:D007674 Kidney Diseases Cadmium Chloride 23.4116962696
MESH:D007674 Kidney Diseases Chromium 23.4117934191
MESH:D007674 Kidney Diseases Mercury 23.4117934191
MESH:D007674 Kidney Diseases Potassium Dichromate 23.4119665454
MESH:D007674 Kidney Diseases sodium arsenite 23.4120008137
MESH:D007896 Leishmaniasis Antimony 4.7510953559 21182181 15220340 12019027 21063981
MESH:D016773 Leishmaniasis, Cutaneous Antimony 4.6111475954 19141829 8889330
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 5.439643325 7854095 11370249 10881086 10651420
MESH:D007898 Leishmaniasis, Visceral Antimony 8.568142506 20495762 7554475 11105143 1899875 7854095 7875148
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 8.5612707265
MESH:D007938 Leukemia arsenic trioxide 6.2315070760
MESH:D007938 Leukemia Tretinoin 6.2317143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.2719077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.2716932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8417050201 16467208 19850784 16968895 20471514
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8419850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 12.669834237
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 12.6615336539 11468182 19075265 17712046 19225113 9834237 16823087 19035177 16331271 16112521 15213294 17107899 16891316 12712474 17217047 19642359 11161223 16330433 17869043 16966277 15622746 12018890 17649720 15748426 12679006
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 12.6617107899 12679006 17339181 17506722 19642359 17217047 17294898 17368321 16823087 17649720 19035177 16331271 17712046 15748426 9834237 16766008 16140955 16788101 17361223 16935935 17301526 19029980 16891316 19225113 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2916882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.269224671
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.1812468960
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 2.7315733078 15504291 15942678 18567088 17465448 16570917 17201889 17534399 17036385 16544323 17881167 18629640 15492853 15339415 17666798 17196135 14568256 16603200 18210741 17198567 17724770 16627068 15864749 15744066 18237412 15591649 15099470 12918455 18239293 16270385 14643895 12925901 15479170 18637143 18672772 15161499 14709902 17640959 14726149 15798949 18095165 15723089 18371158 16169303 15366600 15298665 14659978 17203207 15369754 15793283 17719030 15383259 15067225 18364076 15571005 15081153 15086199 16009107 17432682 15577212 15763062 15138612 15842777 17348192 16042886
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.7316248980 18397230
MESH:D008107 Liver Diseases Sulindac 3.0114986274 16867024
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.3517457977
MESH:D008113 Liver Neoplasms arsenic trioxide 7.4514682389
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 7.4515890375 3113478
MESH:D008113 Liver Neoplasms sodium arsenite 7.4515276417 16712894
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.1120377131
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 6.1115603536 1848544 6150874
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3015213294
MESH:D008171 Lung Diseases sodium arsenite 3.1319095001
MESH:D008175 Lung Neoplasms arsenic trioxide 4.8819825857 11798837
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 4.8816061637 11884234 19555203
MESH:D008175 Lung Neoplasms sodium arsenite 4.8816712894 15276417 17306315 17077188 19931552
MESH:D008175 Lung Neoplasms Sulindac 4.8815713900 19359593
MESH:D008527 Medulloblastoma Tretinoin 2.7617453147
MESH:D008545 Melanoma sodium arsenite 5.1616487513 19082730
MESH:D008545 Melanoma Sulindac 5.1616642371
MESH:D008545 Melanoma Tretinoin 5.1616752155
MESH:D008591 Meningomyelocele Tretinoin 4.3616940565
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0611468182 19417148 14977855 19549372 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.2616105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.2617596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9016624393
MESH:D009362 Neoplasm Metastasis quinoline 4.02598648
MESH:D009369 Neoplasms sodium arsenite 5.0011559025
MESH:D009369 Neoplasms Tretinoin 5.0016946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6020056578
MESH:D009421 Nervous System Malformations Tretinoin 3.719125849
MESH:D009436 Neural Tube Defects arsenic trioxide 11.9010525206
MESH:D009436 Neural Tube Defects sodium arsenite 11.9012854658
MESH:D009436 Neural Tube Defects Tretinoin 11.909142499
MESH:D009447 Neuroblastoma Topotecan 3.8115176712
MESH:D019636 Neurodegenerative Diseases Sulindac 4.2116850258 17266991
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.7816624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.7817306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 7.7816936753
MESH:D010146 Pain Sulindac 6.923291741
MESH:D010146 Pain Tretinoin 6.9216870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.6015580305
MESH:D010190 Pancreatic Neoplasms Sulindac 8.6016820089 11504793
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.6015976015
MESH:D010235 Paraganglioma arsenic trioxide 4.1019927285
MESH:D010409 Penile Diseases Antimony 5.669643325
MESH:D010493 Pericarditis Antimony 6.0520465667
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.3215687053
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.7215572423
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1419131511
MESH:D011471 Prostatic Neoplasms Cadmium 2.1417075824
MESH:D011471 Prostatic Neoplasms Calcitriol 2.1415754350 16644109 18247401 12479363 16289102
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1416039940
MESH:D011507 Proteinuria Tretinoin 3.5416636307
MESH:D011625 Pterygium Tretinoin 4.7316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0416116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9016646077
MESH:D012878 Skin Neoplasms sodium arsenite 9.3418572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.348532709
MESH:D012878 Skin Neoplasms Tretinoin 9.3416467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7412854658
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.2112587719
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4317007042
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 3.4316033868
MESH:D013274 Stomach Neoplasms Tretinoin 3.4317261132
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.0419014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.0416026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7316051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9015213294
MESH:D014352 Trypanosomiasis Antimony 5.8715220340
MESH:D014376 Tuberculosis Tretinoin 3.1916040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.0812973940 12845720 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.0816452187 11723127 17306315 16712894
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.2111813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.2116129372
MESH:D014594 Uterine Neoplasms Sulindac 4.5318645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.5516752155
MESH:D014652 Vascular Diseases sodium arsenite 4.3617056641
MESH:D014820 Vitiligo Tretinoin 3.9916761959
MESH:D009396 Wilms Tumor Tretinoin 3.9116287080
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35046
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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