AutismKB 2.0

Annotation Detail for A2M


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Basic Information Top
Gene Symbol:A2M ( CPAMD5,DKFZp779B086,S863-7 )
Gene Full Name: alpha-2-macroglobulin
Band: 12p13.31
Quick LinksEntrez ID:2; OMIM: 103950; Uniprot ID:A2MG_HUMAN; ENSEMBL ID: ENSG00000175899; HGNC ID: 7
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04610Complement and coagulation cascades
Pathway IDPathway Name
Hemostasis
Signaling by Rho GTPases
Pathway IDPathway Name
200124IL6-mediated signaling events
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1831Prostate cancer
1856Obesity
1877Multiple sclerosis
1932Pancreatitis
1855Prostatic hypertrophy, Benign
2244Prion disease
Desease Name
rheumatoid arthritis
Parkinson's disease
Alzheimer`s Disease
NORMALVARIATION
alpha-2-macroglobulin concentration obesity
Alzheimer's disease
IMMUNE
argyrophilic grain disease
NEUROLOGICAL
METABOLIC
normal variation
No data
Desease Name
Alzheimer disease, susceptibility to
Emphysema due to alpha-2-macroglobulin deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of A2M mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of A2M mRNAaffects expression 21346803
C014464 3,4-dichloroaniline 3,4-dichloroaniline results in decreased expression of A2M mRNAdecreases expression 17292976
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of A2M mRNAdecreases expression 18289764
D000082 Acetaminophen Acetaminophen results in increased expression of A2M mRNAincreases expression 12883083
D000643 Ammonium Chloride Ammonium Chloride affects the expression of A2M mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of A2M mRNAincreases expression 16715494
D000965 Antimony Antimony results in decreased expression of A2M mRNAdecreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in decreased expression of A2M mRNAdecreases expression 17547211
D001414 Bacitracin Bacitracin results in increased expression of A2M mRNAincreases expression 18289764
D019324 beta-Naphthoflavone beta-Naphthoflavone results in decreased expression of A2M mRNAdecreases expression 12883083
C055494 caffeic acid phenethyl ester caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of A2M mRNA]decreases expression|decreases reaction 20360939
D002994 Clofibrate Clofibrate results in increased expression of A2M mRNAincreases expression 12883083
D002995 Clofibric Acid Clofibric Acid affects the expression of A2M mRNAaffects expression 17602206
D003345 Corticosterone Corticosterone results in increased expression of A2M mRNAincreases expression 15755911
D016572 Cyclosporine Cyclosporine results in decreased expression of A2M mRNAdecreases expression 20106945
D003907 Dexamethasone Dexamethasone results in decreased expression of A2M mRNAdecreases expression 12971794
D002945 Cisplatin Cisplatin binds to A2M proteinaffects binding 16773208
D002945 Cisplatin Cisplatin results in increased expression of A2M mRNAincreases expression 18289764
D004052 Diethylnitrosamine caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of A2M mRNA]decreases expression|decreases reaction 20360939
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of A2M proteinaffects cotreatment|increases expression 20935162
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of A2M mRNAdecreases expression 20360939
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of A2M mRNAdecreases expression 17547211
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide results in increased expression of A2M mRNAincreases expression 12883083
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of A2M mRNAdecreases expression 17557909
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in increased expression of A2M proteinincreases expression 10928463
C039281 furan furan results in decreased expression of A2M mRNAdecreases expression 15120968
C113661 imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III) imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III) binds to A2M proteinaffects binding 16773208
D007538 Isoniazid Isoniazid results in increased expression of A2M mRNAincreases expression 12883083
D007654 Ketoconazole Ketoconazole results in decreased expression of A2M mRNAdecreases expression 18289764
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of A2M mRNAincreases expression 11779202
D008628 Mercury Mercury results in decreased expression of A2M mRNAdecreases expression 17547211
D008701 Methapyrilene Methapyrilene results in decreased expression of A2M mRNAdecreases expression 15120968
C031721 naphthalene naphthalene metabolite binds to A2M proteinaffects binding 15892573
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate affects the expression of A2M mRNAaffects expression 18289764
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of A2M mRNAincreases expression 12883083
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of A2M mRNAincreases expression 17616710
D010634 Phenobarbital [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of A2M proteinaffects cotreatment|increases expression 20935162
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of A2M mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of A2M mRNAdecreases expression 16940010
D011374 Progesterone Progesterone affects the expression of A2M mRNAaffects expression 17251523
D012643 Selenium Selenium results in increased expression of A2M mRNAincreases expression 18997278
C017947 sodium arsenite sodium arsenite affects the expression of A2M mRNAaffects expression 19590694
C017947 sodium arsenite sodium arsenite results in increased expression of A2M mRNAincreases expression 16014739
D013853 Thioacetamide Thioacetamide results in increased expression of A2M mRNAincreases expression 16297948
D014425 Turpentine Turpentine results in increased expression of A2M mRNAincreases expression 11779202
D014640 Vancomycin Vancomycin results in increased expression of A2M mRNAincreases expression 18289764
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.026195326
MESH:D000138 Acidosis Ammonium Chloride 3.1318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5017505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.5812690470 17670903 15814532
MESH:D055371 Acute Lung Injury Lipopolysaccharides 7.7318653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 7.7318653653
MESH:D000210 Acute-Phase Reaction Turpentine 5.7416044259
MESH:D000230 Adenocarcinoma Cisplatin 6.4717638652 11798837
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 6.4716033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.4714692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 13.893712494
MESH:D000236 Adenoma beta-Naphthoflavone 13.8919389873
MESH:D000236 Adenoma Diethylnitrosamine 13.8910737359 6695378
MESH:D000236 Adenoma Dimethylnitrosamine 13.8919555203
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.8617620307 19061943 17162532 19052882 18056438 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 14.8617620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.8616434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.4617306315 16712894
MESH:D000544 Alzheimer Disease marker/mechanism
MESH:D000799 Angioedema Acetaminophen 3.4010982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0511256880
MESH:D001169 Arthritis, Experimental Dexamethasone 6.4717659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.4715885639
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Mercury 2.1417497416
MESH:D001327 Autoimmune Diseases Mercury 4.4516634805
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.5811289319 1440618
MESH:D001778 Blood Coagulation Disorders Clofibrate 13.2819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.2819483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 13.2819483382
MESH:D001796 Blood Protein Disorders marker/mechanism
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.4514601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9017868700
MESH:D001930 Brain Injuries Progesterone 3.8415845082 15665606 15380490
MESH:D001943 Breast Neoplasms Cisplatin 2.0219526202 18382427
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0217474063
MESH:D001943 Breast Neoplasms Progesterone 2.0215562024 16175315 17614352
MESH:D001991 Bronchitis Antimony 5.698768112
MESH:D002277 Carcinoma Dimethylnitrosamine 3.6819555203
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 18.2116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 18.2116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 18.217296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 18.213084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 18.2117982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 18.2120101231 16569478 19519916 20214788 17162532 16698587 16807293 17138121 20512989 20727157 19822196 18978308 19418558 16830150 10737359 16878318 17428255 17978847 18665156 19171122 18785209 16502159 11831363 20514400 16779866 16540662 18971187 19539802 21159647 19919837 20084675 16328049 16681979 17055752 18691550 10672840 18056438 16935385 20524982 18788625 18494052 19208518 19394651 18506893 20432363 18393292 19107877 17761372 19383236 20007298 20935162 17173139 18210153 19335982 19052882 3084413 19701751 16288022 3581430
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 18.2120935162 17173139 6705139 20007298 1701930
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 18.2116507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 18.2117997003
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.8812023789 16685392
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.467296757
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 6.8717066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 6.8716033868
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 6.8718572023
MESH:D002311 Cardiomyopathy, Dilated Antimony 6.0010334427
MESH:D002311 Cardiomyopathy, Dilated Mercury 6.0010334427
MESH:D002386 Cataract Acetaminophen 2.3210977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 22.466135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 22.467505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 22.461399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 22.4612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 22.4617174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 22.4619524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.834080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5319052882
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.5318291259
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.7612912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 21.887624871 18590720 15500046 12927374 16629650 18164287 19486331 15913567
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 21.889022650 19486331
MESH:D002779 Cholestasis Cyclosporine 21.8819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 21.8817681005 16919318 17110522 11677210 17333356 16105132 15861022
MESH:D002779 Cholestasis pirinixic acid 21.8819176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.4119407337 10220858
MESH:D003092 Colitis Selenium 3.3617936198
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4215824018
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3215273666
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.2617728286
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.4918551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 9.2911298694 8156756 18759878 11906362 14531868 2524372 8970840 12868966
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 9.2912438553
MESH:D017449 Dermatitis, Allergic Contact Mercury 9.2916823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.102952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.0820387270
MESH:D003929 Diabetic Neuropathies Progesterone 4.0717187935
MESH:D003967 Diarrhea Dexamethasone 3.307237001
MESH:D004283 Dog Diseases Antimony 5.2212019027
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 30.1120133375 17522070 7624871 18289764
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 30.1118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 30.1118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 30.116679447 9022650 9328219 7440962 18692083 18648102 11289319 8291058 6482804 1440618 18289764 9653073 16192314
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 30.1116109766 11834606 2444490 14725611 16081117 16227642 19085960 16781746 16177239 18071297 19420014 11461765 16393943 19416960 17562736 14986274 10774834 15968718 16485898 17522070 19923254 11421492 12958197 12705907 19370779 17906064 15619225 18713872 12392966 11739529 12594235 10915739 10663392 14550746 11287661 11743745 19164858 12153990 12540782 11529661 19739265
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 30.1119107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 30.118172417
MESH:D056486 Drug-Induced Liver Injury Isoniazid 30.1114986274 17950035 16770646
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 30.1118289764
MESH:D056486 Drug-Induced Liver Injury Selenium 30.1115131321
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 30.1112963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6619426721
MESH:D004362 Drug Toxicity Cisplatin 3.5412649298 12231392 19839026 15033597
MESH:D050171 Dyslipidemias Clofibrate 3.7516707586
MESH:D004421 Dystonia Phenobarbital 3.611851702
MESH:D004485 Eczema Dexamethasone 4.0512438553
MESH:D004487 Edema Dexamethasone 5.6619703484
MESH:D004487 Edema pirinixic acid 5.6612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.6812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.6817692515
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 6.1220641076
MESH:D004715 Endometriosis Progesterone 3.3916134523
MESH:D019446 Endotoxemia Lipopolysaccharides 3.9715328337 17637181 15821434
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.693659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.433922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.6620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.186401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.837750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.593659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6816302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 9.413581430
MESH:D004938 Esophageal Neoplasms Cisplatin 9.4116481741 15173087 15464296 16785472 17638652
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 9.4117016578
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 9.4115878914 16510608 15150132 15547733 16704527 15264214 16805852 15623463 15547721
MESH:D005218 Fat Necrosis Thioacetamide 5.2816456712
MESH:D005234 Fatty Liver Clofibrate 20.5719224547
MESH:D005234 Fatty Liver Cyclosporine 20.5719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 20.5720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.5715345470
MESH:D005234 Fatty Liver pirinixic acid 20.5719236843 20131406
MESH:D005334 Fever Lipopolysaccharides 3.6411852909 9205823
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.586705139
MESH:D005355 Fibrosis Cyclosporine 2.7312168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.2416983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.798708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.647505956
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.4215102660 15464296
MESH:D034381 Hearing Loss Cisplatin 9.1919898482
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 9.1920641076
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.0715464296
MESH:D006333 Heart Failure pirinixic acid 6.0420558911
MESH:D006333 Heart Failure Selenium 6.0417162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9915720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0116366002
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.1918665440 17276928 15929193
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 13.5118590720
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 13.516705139
MESH:D006505 Hepatitis Thioacetamide 13.5116456712
MESH:D006529 Hepatomegaly Phenobarbital 7.0916109766
MESH:D006529 Hepatomegaly pirinixic acid 7.0919772884 19176532 18467677 16221962
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.917520565
MESH:D006689 Hodgkin Disease Cisplatin 6.3616170182 16200630
MESH:D006689 Hodgkin Disease sodium arsenite 6.3612676792
MESH:D006930 Hyperalgesia Acetaminophen 2.3716870215
MESH:D006943 Hyperglycemia pirinixic acid 2.8120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5215034207
MESH:D006973 Hypertension Cyclosporine 4.7310903974
MESH:D006973 Hypertension Dexamethasone 4.7317042910
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3916569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9815869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.6717937319
MESH:D007248 Infertility, Male sodium arsenite 5.6712646999 15346721
MESH:D007249 Inflammation Dexamethasone 10.0811099482 8960868
MESH:D007249 Inflammation Diethylnitrosamine 10.0818785209
MESH:D007249 Inflammation Lipopolysaccharides 10.0817255318 9205823 17963957 12878042 17237260
MESH:D007249 Inflammation Progesterone 10.0815869954
MESH:D007251 Influenza, Human Selenium 3.7616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.3516306350
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.2110783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.2317255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.589022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0015604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7015464296
MESH:D007674 Kidney Diseases Acetaminophen 29.4515629191 12587719
MESH:D007674 Kidney Diseases Bacitracin 29.4518289764
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 29.4515369732
MESH:D007674 Kidney Diseases Cisplatin 29.4518289764 12231392 12649298 19839026 15190930
MESH:D007674 Kidney Diseases Cyclosporine 29.4518776723 10903974 8314463
MESH:D007674 Kidney Diseases Mercury 29.4517934191
MESH:D007674 Kidney Diseases sodium arsenite 29.4520008137
MESH:D007674 Kidney Diseases Vancomycin 29.4518289764
MESH:D007676 Kidney Failure, Chronic Selenium 3.5016518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.8716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.8716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 14.876582329
MESH:D007680 Kidney Neoplasms Cyclosporine 14.8712371664
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.3611231351
MESH:D007896 Leishmaniasis Antimony 4.4521182181 15220340 21063981 10953559 12019027
MESH:D016773 Leishmaniasis, Cutaneous Antimony 8.088889330 11475954 19141829
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 8.088889330 2166429 19744259 1311351
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 5.0611370249 9643325 7854095 10881086 10651420
MESH:D007898 Leishmaniasis, Visceral Antimony 11.6011105143 7875148 8142506 7854095 20495762 7554475 1899875
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 11.6012707265
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 11.6011332679
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 7.479834237
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 7.4716766008
MESH:D007970 Leukopenia Lipopolysaccharides 4.2715821434
MESH:D008064 Lipidoses Ketoconazole 4.2617567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.8218407596 20032147 19638242 18665156 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 5.8221047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.929327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 7.9016718785
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 7.9018637143 15138612 17198567 17881167 18567088 18237412 16169303 14659978 17201889 16603200 15744066 15842777 17534399 16544323 15793283 18371158 16627068 12925901 18629640 15733078 15504291 17203207 15798949 12918455 18239293 15161499 15577212 15298665 16042886 15591649 18672772 17196135 14643895 18210741 17465448 16570917 15479170 15366600 16270385 15723089 15369754 17724770 17640959 17432682 15383259 14568256 15067225 15571005 15339415 17666798 14709902 15086199 15763062 15099470 15492853 18095165 18364076 17719030 17348192 17036385 14726149 16009107 15081153 15864749 15942678
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 7.9011682029
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 7.9012878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 7.9015474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 7.9012531686 15334695 15075984 12891558 18295389 18395095 11172339 16511523 11481614 18606216 17050028 14739098 15078482 16098781 15316131 17127702 17629604 12557150 16126171 18615449 18416461 12085344 18032466 18263696 18380797 12679928 18458672 15288473 15158331 10677585 17292413 16489207 15288472 16097051 15095483 18031379 15362042 12175628 11682029 15474484 15465738 17355460 16343077 15716488 16248980
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 11.1517184895
MESH:D008107 Liver Diseases Acetaminophen 11.1511587558 19014921 12587719 12969438 19784758 19460945 16610002 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 11.1517034775
MESH:D008107 Liver Diseases Phenobarbital 11.1519363144
MESH:D008107 Liver Diseases Thioacetamide 11.1516337175 18374380 15158337
MESH:D017114 Liver Failure, Acute Acetaminophen 14.1916871587 17185352
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 14.1917457977
MESH:D017114 Liver Failure, Acute Thioacetamide 14.1915313186 17276928 15633222 12479984
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 26.587678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 26.5819389873 21295105
MESH:D008113 Liver Neoplasms Clofibric Acid 26.5817602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 26.5820501860 19638242 19256749 12771043 19551842 19426721 20405173 18644402 19850985 21047994 9163691 19812893 20434301 19833225 20492335 20452335 10737359 21278145 19073162 19499222 19090486 20137499 2422723 16942905 15885732 19427195 20118626 18754104 18978307 18977376 20101389 15175105 2862719 19294768 19996281 21071580 19690152 20583210 19642983 21167192 19254457 19255062 18648771 12112319
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 26.583113478 15890375
MESH:D008113 Liver Neoplasms Methapyrilene 26.5815890375
MESH:D008113 Liver Neoplasms Phenobarbital 26.5821047994 8742319 19073162 19482888 19812893 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 26.5816377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 26.5815276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 19.792876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 19.79598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 19.7918164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.7919539802 18093689 16267830 18775883 9362446 18544905 16842330 3124819 19009564 18079962 19519916 19126423 18308698 2563599 18282651 17854601 18164116 18253720 19004024 17174075 17942915 21159647
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 19.791848544 6150874 15603536
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 19.791399818 18308698 17172636 6150874 2563599
MESH:D008171 Lung Diseases sodium arsenite 2.8819095001
MESH:D008173 Lung Diseases, Obstructive marker/mechanism
MESH:D055370 Lung Injury Lipopolysaccharides 8.2821114838
MESH:D055370 Lung Injury naphthalene 8.286834280
MESH:D008175 Lung Neoplasms marker/mechanism 17902193 19180532
MESH:D008175 Lung Neoplasms Cisplatin 5.9511798837 6189445 17225452
MESH:D008175 Lung Neoplasms Dexamethasone 5.9511195469 15824018
MESH:D008175 Lung Neoplasms Diethylnitrosamine 5.9520512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 5.9516061637 19555203 11884234
MESH:D008175 Lung Neoplasms sodium arsenite 5.9517306315 15276417 16712894 17077188 19931552
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 8.5012807724
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.5017203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 8.5015318939
MESH:D008545 Melanoma Cisplatin 3.2615577323 16809738 17023156 12393984 12374674 18176117 16248763 16432458 17761969 18505091 18332650 11135225 12883367
MESH:D008545 Melanoma sodium arsenite 3.2616487513 19082730
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.3415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1519513568
MESH:D008654 Mesothelioma Cisplatin 5.7417638057
MESH:D008654 Mesothelioma Selenium 5.7415107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3516801185
MESH:D008708 Methemoglobinemia 3,4-dichloroaniline 5.364714336
MESH:D009041 Motion Sickness Dextroamphetamine 5.081613127
MESH:D009101 Multiple Myeloma Dexamethasone 3.2016118317 15744524 15867202
MESH:D009135 Muscular Diseases pirinixic acid 3.0916239165
MESH:D009164 Mycobacterium Infections Isoniazid 5.5318474467
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.299809623
MESH:D009203 Myocardial Infarction pirinixic acid 1.9619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0417484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.9118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.917678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.083581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.083581430 9029167
MESH:D009369 Neoplasms Cisplatin 10.1516773208
MESH:D009369 Neoplasms imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III) 10.1516773208
MESH:D009369 Neoplasms pirinixic acid 10.1517405874
MESH:D009369 Neoplasms sodium arsenite 10.1511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.2520056578
MESH:D009395 Nephritis, Interstitial Cisplatin 4.0615464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9218481113 19348381
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.316679447
MESH:D009436 Neural Tube Defects sodium arsenite 6.3112854658
MESH:D009447 Neuroblastoma Cisplatin 3.228761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.0218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.0220387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.278761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6820387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.529802331
MESH:D009765 Obesity pirinixic acid 1.7020558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 12.9116049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 12.9116049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 12.916482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.583988306
MESH:D010018 Osteomalacia Phenobarbital 3.9317016548
MESH:D010051 Ovarian Neoplasms Cisplatin 7.106897625 19769630 15464296 17225452
MESH:D010051 Ovarian Neoplasms Progesterone 7.1017393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.1017306315 15276417
MESH:D010146 Pain Acetaminophen 2.0616870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 7.6819003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 7.6816540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 7.6816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.077296757
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 5.4120133375
MESH:D010409 Penile Diseases Antimony 5.319643325
MESH:D010493 Pericarditis Antimony 5.6820465667
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.9015464296
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.036228378
MESH:D010954 Plasmacytoma Selenium 4.4515087411
MESH:D010997 Pleural Neoplasms Cisplatin 4.9017638057
MESH:D011014 Pneumonia Lipopolysaccharides 4.1211605937 12224865
MESH:D011085 Polycystic Ovary Syndrome ethinyl estradiol-desogestrel combination 5.2217105841
MESH:D011230 Precancerous Conditions Cyclosporine 13.1812371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 13.182563599
MESH:D011230 Precancerous Conditions Phenobarbital 13.182563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3021297632
MESH:D011471 Prostatic Neoplasms Ketoconazole 3.9517404083
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.9516039940
MESH:D011537 Pruritus Ethinyl Estradiol 2.8915861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.0612752131
MESH:D011565 Psoriasis Cyclosporine 2.0716882103
MESH:D051437 Renal Insufficiency Cisplatin 3.9915464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.1719058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.6218379247 11700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4410835634
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.053692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6918045962
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.0214601052
MESH:D012640 Seizures 2,4-dinitrotoluene 11.7218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 11.7218551238
MESH:D012640 Seizures Isoniazid 11.7216107249
MESH:D012640 Seizures Phenobarbital 11.7216876388 3137016 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.396407741
MESH:D012878 Skin Neoplasms sodium arsenite 2.4918572023 19524636
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9015464296
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5016709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.8515862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4612854658
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.8312587719
MESH:D013272 Stomach Diseases Dexamethasone 3.8915472012
MESH:D013274 Stomach Neoplasms Cisplatin 4.3717522103 18396642 15958060
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.3718456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 4.3716033868
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.3712958204 17575124
MESH:D013276 Stomach Ulcer Dexamethasone 3.1215138204
MESH:D013736 Testicular Neoplasms Cisplatin 4.2315464296 17225452
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 8.8020133375
MESH:D013921 Thrombocytopenia Lipopolysaccharides 8.8015821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 9.7911994571
MESH:D019851 Thrombophilia ethinyl estradiol-desogestrel combination 9.7911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7915669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.066582329 7505956 1399818 3712494 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.067505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.061399818
MESH:D014352 Trypanosomiasis Antimony 5.4915220340
MESH:D014376 Tuberculosis Isoniazid 4.9117720495 18397238 15236969 16770646 17950035 15673755
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 13.8416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 13.8416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 13.848074119
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 13.8417225452 15464296 12973940
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 13.8416452187 11723127 17306315 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.5510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.5510091137
MESH:D014581 Urticaria Acetaminophen 2.5810982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 8.3716803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.3711813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8914692618
MESH:D014605 Uveitis Cyclosporine 10.301336536
MESH:D014605 Uveitis Dexamethasone 10.301336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.1915577323
MESH:D014652 Vascular Diseases sodium arsenite 3.9917056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 9.5514671159 15869587
MESH:D020246 Venous Thrombosis ethinyl estradiol-desogestrel combination 9.5515869587
MESH:D014839 Vomiting Cisplatin 4.2811897121
MESH:D014985 Xerophthalmia Cyclosporine 4.0017120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:604 Hemostasis
REACT:11044 Signaling by Rho GTPases
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24357
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    Releated drug ID Related drug Name
    PA452347glucocorticoids
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00102 - Becaplermin Anti-Ulcer Agents;Topical
    DB00626 antagonist Sandoz Cortimyxin Anti-Bacterial Agents;Anti-Infective Agents, Local
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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