AutismKB 2.0

Annotation Detail for ELK1


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Basic Information Top
Gene Symbol:ELK1 ( - )
Gene Full Name: ELK1, member of ETS oncogene family
Band: Xp11.23
Quick LinksEntrez ID:2002; OMIM: 311040; Uniprot ID:ELK1_HUMAN; ENSEMBL ID: ENSG00000126767; HGNC ID: 3321
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04912GnRH signaling pathway
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway
hsa04010MAPK signaling pathway
hsa05140Leishmaniasis
hsa05213Endometrial cancer
hsa04510Focal adhesion
hsa05020Prion diseases
Pathway IDPathway Name
Signalling by NGF
Signaling in Immune system
Pathway IDPathway Name
200030HIF-2-alpha transcription factor network
200181S1P2 pathway
200182Trk receptor signaling mediated by the MAPK pathway
200184Downstream signaling in naive CD8+ T cells
200005BCR signaling pathway
200088Ras signaling in the CD4+ TCR pathway
200140PDGFR-alpha signaling pathway
200066Angiopoietin receptor Tie2-mediated signaling
200113ErbB1 downstream signaling
Pathway IDPathway Name
P00046Oxidative stress response
P00054Toll receptor signaling pathway
P00049Parkinson disease
P00047PDGF signaling pathway
P00032Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
P00036Interleukin signaling pathway
P04393Ras Pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1860Brain tumor
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C013813 4-anisidine 4-anisidine results in decreased expression of ELK1 mRNAdecreases expression 12929121
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of ELK1 mRNAdecreases expression 12419474
C121465 6-methyl-2-(phenylethynyl)pyridine 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Dextroamphetamine results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 12377393
D003913 Dextroamphetamine 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Dextroamphetamine results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 12377393
D003913 Dextroamphetamine Dextroamphetamine results in increased phosphorylation of ELK1 proteinincreases phosphorylation 12377393
D003913 Dextroamphetamine N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Dextroamphetamine results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 12377393
D000841 Anisomycin Anisomycin results in increased phosphorylation of ELK1 proteinincreases phosphorylation 12660819
D000841 Anisomycin anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Anisomycin results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 12660819
D000841 Anisomycin PD 98059 inhibits the reaction [Anisomycin results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 12660819
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Anisomycin results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 12660819
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 18316600
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [sodium arsenite results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 12660819
C015001 arsenite arsenite promotes the reaction [ELK1 protein binds to DDIT4 promoter]affects binding|increases reaction 16008523
C015001 arsenite arsenite results in increased activity of ELK1 proteinincreases activity 16008523
D020148 Butyric Acid Butyric Acid results in increased activity of ELK1 proteinincreases activity 15103026
D020148 Butyric Acid U 0126 inhibits the reaction [Butyric Acid results in increased activity of ELK1 protein]decreases reaction|increases activity 15103026
D003024 Clozapine Clozapine results in decreased phosphorylation of ELK1 proteindecreases phosphorylation 12871586
D003474 Curcumin anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 18316600
D003474 Curcumin Curcumin results in increased phosphorylation of ELK1 proteinincreases phosphorylation 18316600
D003474 Curcumin U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 18316600
D003513 Cycloheximide Cycloheximide results in increased expression of ELK1 mRNAincreases expression 19684285
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of ELK1 mRNAaffects cotreatment|increases expression 19684285
C004742 daidzein daidzein results in increased phosphorylation of and results in increased activity of ELK1 proteinincreases activity|increases phosphorylation 16972265
D004958 Estradiol Estradiol results in increased phosphorylation of and results in increased activity of ELK1 proteinincreases activity|increases phosphorylation 16024245
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ELK1 mRNAaffects cotreatment|increases expression 17942748
C045989 eticlopride eticlopride results in increased phosphorylation of ELK1 proteinincreases phosphorylation 12871586
D006220 Haloperidol Haloperidol results in increased phosphorylation of ELK1 proteinincreases phosphorylation 12871586
D006220 Haloperidol SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 12871586
D017313 Fenretinide PD 98059 inhibits the reaction [Fenretinide results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 16407847
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of ELK1 mRNAdecreases expression 12419474
C067431 letrozole letrozole results in increased expression of ELK1 proteinincreases expression 15967659
C013598 methoxyacetic acid methoxyacetic acid promotes the reaction [EGF protein results in increased activity of ELK1 protein]increases activity|increases reaction 15103026
C013598 methoxyacetic acid methoxyacetic acid results in increased activity of ELK1 proteinincreases activity 15103026
C013598 methoxyacetic acid U 0126 inhibits the reaction [methoxyacetic acid promotes the reaction [EGF protein results in increased activity of ELK1 protein]]decreases reaction|increases activity|increases reaction 15103026
C013598 methoxyacetic acid U 0126 inhibits the reaction [methoxyacetic acid results in increased activity of ELK1 protein]decreases reaction|increases activity 15103026
C442478 N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Dextroamphetamine results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 12377393
D017239 Paclitaxel Paclitaxel results in decreased expression of ELK1 mRNAdecreases expression 12929121
C093973 PD 98059 PD 98059 inhibits the reaction [Anisomycin results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 12660819
C093973 PD 98059 PD 98059 inhibits the reaction [Fenretinide results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 16407847
C093973 PD 98059 PD 98059 inhibits the reaction [sodium arsenite results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 12660819
C093973 PD 98059 PD 98059 inhibits the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]decreases reaction|increases activity|increases phosphorylation 17599376
C093973 PD 98059 [SB 203580 co-treated with PD 98059] inhibits the reaction [sodium arsenite results in increased phosphorylation of ELK1 protein]affects cotreatment|decreases reaction|increases phosphorylation 12660819
C093973 PD 98059 PD 98059 inhibits the reaction [Phenylephrine results in increased expression of ELK1 mRNA]decreases reaction|increases expression 10900171
D010656 Phenylephrine MAPK1 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]affects reaction|increases expression 10900171
D010656 Phenylephrine MAPK3 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]affects reaction|increases expression 10900171
D010656 Phenylephrine PD 98059 inhibits the reaction [Phenylephrine results in increased expression of ELK1 mRNA]decreases reaction|increases expression 10900171
D010656 Phenylephrine Phenylephrine promotes the reaction [ELK1 protein modified form binds to FOS promoter]affects binding|increases reaction 10900171
D010656 Phenylephrine Phenylephrine results in increased expression of ELK1 mRNAincreases expression 10900171
D010656 Phenylephrine Phenylephrine results in increased phosphorylation of ELK1 proteinincreases phosphorylation 10900171
C093642 SB 203580 [SB 203580 co-treated with PD 98059] inhibits the reaction [sodium arsenite results in increased phosphorylation of ELK1 protein]affects cotreatment|decreases reaction|increases phosphorylation 12660819
C424127 SL 327 SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 12871586
C017947 sodium arsenite anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [sodium arsenite results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 12660819
C017947 sodium arsenite PD 98059 inhibits the reaction [sodium arsenite results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 12660819
C017947 sodium arsenite [SB 203580 co-treated with PD 98059] inhibits the reaction [sodium arsenite results in increased phosphorylation of ELK1 protein]affects cotreatment|decreases reaction|increases phosphorylation 12660819
C017947 sodium arsenite sodium arsenite results in increased activity of ELK1 proteinincreases activity 15292961
C017947 sodium arsenite sodium arsenite results in increased expression of ELK1 mRNAincreases expression 12016162
C017947 sodium arsenite sodium arsenite results in increased phosphorylation of ELK1 proteinincreases phosphorylation 12660819
C025462 sulindac sulfide ELK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]increases expression|increases reaction 17599376
C025462 sulindac sulfide MAPK1 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]increases activity|increases phosphorylation|increases reaction 17599376
C025462 sulindac sulfide MAPK3 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]increases activity|increases phosphorylation|increases reaction 17599376
C025462 sulindac sulfide PD 98059 inhibits the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]decreases reaction|increases activity|increases phosphorylation 17599376
C025462 sulindac sulfide sulindac sulfide results in increased phosphorylation of and affects the activity of ELK1 proteinaffects activity|increases phosphorylation 17599376
C025462 sulindac sulfide U 0126 inhibits the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]decreases reaction|increases activity|increases phosphorylation 17599376
C004648 testosterone enanthate testosterone enanthate affects the expression of ELK1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of ELK1 mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ELK1 mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ELK1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ELK1 mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ELK1 mRNAincreases expression 15897893
C012589 trichostatin A trichostatin A results in increased activity of ELK1 proteinincreases activity 15103026
C012589 trichostatin A U 0126 inhibits the reaction [trichostatin A results in increased activity of ELK1 protein]decreases reaction|increases activity 15103026
C113580 U 0126 U 0126 inhibits the reaction [Butyric Acid results in increased activity of ELK1 protein]decreases reaction|increases activity 15103026
C113580 U 0126 U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]decreases reaction|increases phosphorylation 18316600
C113580 U 0126 U 0126 inhibits the reaction [methoxyacetic acid promotes the reaction [EGF protein results in increased activity of ELK1 protein]]decreases reaction|increases activity|increases reaction 15103026
C113580 U 0126 U 0126 inhibits the reaction [methoxyacetic acid results in increased activity of ELK1 protein]decreases reaction|increases activity 15103026
C113580 U 0126 U 0126 inhibits the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]decreases reaction|increases activity|increases phosphorylation 17599376
C113580 U 0126 U 0126 inhibits the reaction [trichostatin A results in increased activity of ELK1 protein]decreases reaction|increases activity 15103026
C113580 U 0126 U 0126 inhibits the reaction [Valproic Acid promotes the reaction [EGF protein results in increased activity of ELK1 protein]]decreases reaction|increases activity|increases reaction 15103026
C113580 U 0126 U 0126 inhibits the reaction [Valproic Acid results in increased activity of ELK1 protein]decreases reaction|increases activity 15103026
D014635 Valproic Acid U 0126 inhibits the reaction [Valproic Acid promotes the reaction [EGF protein results in increased activity of ELK1 protein]]decreases reaction|increases activity|increases reaction 15103026
D014635 Valproic Acid U 0126 inhibits the reaction [Valproic Acid results in increased activity of ELK1 protein]decreases reaction|increases activity 15103026
D014635 Valproic Acid Valproic Acid promotes the reaction [EGF protein results in increased activity of ELK1 protein]increases activity|increases reaction 15103026
D014635 Valproic Acid Valproic Acid results in increased activity of ELK1 proteinincreases activity 15103026
D015032 Zinc Zinc results in increased phosphorylation of and results in increased activity of ELK1 proteinincreases activity|increases phosphorylation 16960431
C016837 zinc chloride zinc chloride results in increased phosphorylation of and results in increased activity of ELK1 proteinincreases activity|increases phosphorylation 16960431
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methoxyacetic acid 12.341761407 1761404 3652986 15959878 12805644
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.3414514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 12.348875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6119490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5817505938
MESH:D000168 Acrocephalosyndactylia U 0126 5.1317694057
MESH:D000169 Acrodermatitis Zinc 5.0516889938 17190629 17202136
MESH:D000230 Adenocarcinoma daidzein 9.4311473722
MESH:D000230 Adenocarcinoma Estradiol 9.4311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.4314692618
MESH:D000230 Adenocarcinoma Fenretinide 9.4310697514
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5417306315 16712894
MESH:D000380 Agranulocytosis Clozapine 4.7112649775 14617031 16160616
MESH:D019973 Alcohol-Related Disorders Curcumin 4.7217887948
MESH:D000544 Alzheimer Disease Curcumin 6.3115590663
MESH:D000544 Alzheimer Disease sulindac sulfide 6.3118759972
MESH:D000544 Alzheimer Disease Zinc 6.3117119284 16410023 16325427 16580781
MESH:D000550 Amblyopia Valproic Acid 4.8717688650
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.8810965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6411748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.5616916123
MESH:D001008 Anxiety Disorders Valproic Acid 3.3017497229
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.8117460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4515885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6516807698
MESH:D001249 Asthma Zinc 2.8417085522
MESH:D050197 Atherosclerosis Curcumin 3.1118704882
MESH:D001321 Autistic Disorder Haloperidol 2.3418080171 19368416
MESH:D001321 Autistic Disorder Valproic Acid 2.3418985861 18775368 18558336 19232924 18316065 19460635 17507914 18396377 20603192 16609825 15238991 18177632 17157402 17688650 18940202
MESH:D001327 Autoimmune Diseases Curcumin 4.1519761891
MESH:D001714 Bipolar Disorder Valproic Acid 2.8917594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.7312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.2615746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.268888407
MESH:D001859 Bone Neoplasms Paclitaxel 4.2415867366
MESH:D001919 Bradycardia Phenylephrine 4.1915306635
MESH:D001930 Brain Injuries Zinc 4.3417109824
MESH:D002545 Brain Ischemia Curcumin 3.9816770732
MESH:D001932 Brain Neoplasms Curcumin 8.1517596214
MESH:D001932 Brain Neoplasms Fenretinide 8.1516187019
MESH:D001943 Breast Neoplasms Curcumin 2.7916243823 19250217 18462866 18593918
MESH:D001943 Breast Neoplasms Estradiol 2.7917289903 18497071 12948864 19861407 14630087 17261762 16675129 17018787
MESH:D001943 Breast Neoplasms Fenretinide 2.7916601279
MESH:D001943 Breast Neoplasms letrozole 2.7917892469 16002280
MESH:D001943 Breast Neoplasms Paclitaxel 2.7915136595 11325840 16273361 18234424 16244791 18223236 16115903 18323546
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.7920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1116111702
MESH:D002277 Carcinoma Curcumin 7.3618593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.3616835633
MESH:D006528 Carcinoma, Hepatocellular anthra(1,9-cd)pyrazol-6(2H)-one 8.2319418558
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.2316924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 8.2317159502 16270382
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 8.2316313753
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.2317306315 16507464 15276417
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.5018414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 5.5012391285
MESH:D002294 Carcinoma, Squamous Cell Curcumin 9.9618462866
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 9.9616274795
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 9.9618572023
MESH:D002294 Carcinoma, Squamous Cell Zinc 9.9616543248
MESH:D006332 Cardiomegaly Phenylephrine 6.2215728586 17287366 17124262 11754973 16170337 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2218850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases daidzein 11.0016332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 11.0016936243
MESH:D002318 Cardiovascular Diseases Zinc 11.0016936243
MESH:D002375 Catalepsy Haloperidol 4.5615215559 1977408
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.9418566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 5.9420056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.1216154183
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8716835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6216919318 17110522 15861022 17681005 11677210 16105132 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9515340226 15668235 12621046 16354765 8697196
MESH:D003072 Cognition Disorders Clozapine 4.6217123785
MESH:D003092 Colitis Curcumin 3.8316782535 16804969 18200517
MESH:D003103 Coloboma Curcumin 4.2318809619
MESH:D003110 Colonic Neoplasms arsenite 3.8215037631
MESH:D003110 Colonic Neoplasms Curcumin 3.8219359593 16340194
MESH:D015179 Colorectal Neoplasms Fenretinide 2.9217273769
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.9218802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7617141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.5518497527
MESH:D019465 Craniofacial Abnormalities 6-methyl-2-(phenylethynyl)pyridine 5.1717065172
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.1710048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.1716575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Zinc 5.1719302082
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.5220210726
MESH:D003704 Dementia Haloperidol 4.2611575062
MESH:D003920 Diabetes Mellitus Zinc 3.9116479319
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 9.5316402076
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 9.5318403477
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 9.5316647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.5317107852
MESH:D003928 Diabetic Nephropathies Curcumin 8.0518204486
MESH:D003928 Diabetic Nephropathies Estradiol 8.0519279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.1915331141
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.4120420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.411733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5011462148
MESH:D004381 Duodenal Ulcer Curcumin 3.7217351913
MESH:D050171 Dyslipidemias Clozapine 3.9316402076
MESH:D004421 Dystonia Valproic Acid 3.721851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.0812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5415322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.8512538720
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 5.2819294695
MESH:D016889 Endometrial Neoplasms daidzein 7.0811473722
MESH:D016889 Endometrial Neoplasms Estradiol 7.0819148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.8117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.563922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.7520417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.296426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.957750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.713659116
MESH:D007172 Erectile Dysfunction daidzein 4.6814972507
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.6316481741
MESH:D004938 Esophageal Neoplasms Zinc 4.6316543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7511564622
MESH:D005234 Fatty Liver arsenite 16.2418296743
MESH:D005234 Fatty Liver Curcumin 16.2419297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.2415345470
MESH:D005234 Fatty Liver Valproic Acid 16.2414986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1111858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.798888407 18558336
MESH:D005355 Fibrosis arsenite 12.9018296743
MESH:D005355 Fibrosis Curcumin 12.9018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.9020067830
MESH:D005532 Foot Deformities, Congenital methoxyacetic acid 5.383652986
MESH:D005756 Gastritis Zinc 4.4417241300
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.3518462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3216452187
MESH:D005909 Glioblastoma Curcumin 10.8017596214
MESH:D005909 Glioblastoma Fenretinide 10.8016187019
MESH:D005909 Glioblastoma trichostatin A 10.8018801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2310696789
MESH:D006130 Growth Disorders Zinc 3.7317217573
MESH:D006258 Head and Neck Neoplasms Curcumin 3.4218462866 18829502
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1411294989 10048152
MESH:D006333 Heart Failure Zinc 3.3917162251
MESH:D006335 Heart Injuries Zinc 5.4117074742
MESH:D016481 Helicobacter Infections Zinc 4.2117241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0211000095
MESH:D006527 Hepatolenticular Degeneration Zinc 4.3417276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5516120746 15340226 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.6917701891
MESH:D006558 Herpes Genitalis Estradiol 4.6715709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.3917440010
MESH:D006689 Hodgkin Disease sodium arsenite 2.8712676792
MESH:D019584 Hot Flashes Estradiol 3.3917088409
MESH:D006849 Hydrocephalus Valproic Acid 4.5117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6816354765 8697196 18606429 16959395 15340226
MESH:D006937 Hypercholesterolemia Curcumin 3.7418704882
MESH:D006948 Hyperkinesis Clozapine 4.5616046005
MESH:D006973 Hypertension daidzein 7.9917169123
MESH:D006973 Hypertension Phenylephrine 7.9912717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.9918850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.2418502941 12791704
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4616569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.8617937319
MESH:D007248 Infertility, Male sodium arsenite 5.8612646999 15346721
MESH:D007249 Inflammation Curcumin 4.4716956363 17151092 18403477
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.4712878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0618596194 18200517
MESH:D007333 Insulin Resistance Estradiol 2.7416627594 16393666
MESH:D007414 Intestinal Neoplasms Curcumin 3.9110783313
MESH:D007511 Ischemia Zinc 4.2916584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0216580747
MESH:D007674 Kidney Diseases Estradiol 8.9915618244
MESH:D007674 Kidney Diseases sodium arsenite 8.9920008137
MESH:D007674 Kidney Diseases Zinc 8.9916960431
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.1716518626
MESH:D007676 Kidney Failure, Chronic Zinc 9.1716518626
MESH:D007680 Kidney Neoplasms Estradiol 2.7015610895
MESH:D007889 Leiomyoma Curcumin 4.2518555241
MESH:D007938 Leukemia Curcumin 3.0618462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.8916106398
MESH:D007948 Leukemia, Monocytic, Acute anthra(1,9-cd)pyrazol-6(2H)-one 17.7616972261
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 17.7616972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 17.7616972261
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 3.9518206229
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9516294345 17596541
MESH:D015458 Leukemia, T-Cell Curcumin 4.4316106398
MESH:D007972 Leukoplakia, Oral Fenretinide 5.6816707609
MESH:D017880 Limb Deformities, Congenital methoxyacetic acid 4.4912805644 15959878
MESH:D008064 Lipidoses Clozapine 3.7117567588
MESH:D008080 Liposarcoma Paclitaxel 4.4917353645
MESH:D008103 Liver Cirrhosis arsenite 3.2218296743
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.2417355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.2414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.2412878042
MESH:D008107 Liver Diseases Curcumin 2.5316956363
MESH:D008113 Liver Neoplasms sodium arsenite 3.9916712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 3.9916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 1.8912151625
MESH:D008171 Lung Diseases sodium arsenite 2.9419095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.9017228818
MESH:D008175 Lung Neoplasms arsenite 4.5016809336
MESH:D008175 Lung Neoplasms Curcumin 4.5018462866 19359593 16243823
MESH:D008175 Lung Neoplasms sodium arsenite 4.5019931552 16712894 15276417 17306315 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.5019555203 11884234
MESH:D008223 Lymphoma Curcumin 3.3418462866
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.8114749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.3516173963
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.8311807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 8.8310697514
MESH:D008325 Mammary Neoplasms, Experimental Zinc 8.8312773700
MESH:D020149 Manganese Poisoning Estradiol 4.1219453300
MESH:D008545 Melanoma Curcumin 9.0617885582 18462866
MESH:D008545 Melanoma Fenretinide 9.0616270382
MESH:D008545 Melanoma Paclitaxel 9.0612025231 12040289 16342250
MESH:D008545 Melanoma sodium arsenite 9.0616487513 19082730
MESH:D008545 Melanoma trichostatin A 9.0616505122
MESH:D008569 Memory Disorders Curcumin 3.8217263510
MESH:D001523 Mental Disorders Clozapine 7.2016856516
MESH:D001523 Mental Disorders Haloperidol 7.2016856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.1219142101
MESH:D008881 Migraine Disorders Valproic Acid 2.9418803445 18765137
MESH:D009041 Motion Sickness Dextroamphetamine 5.161613127
MESH:D009062 Mouth Neoplasms Fenretinide 4.0516274795
MESH:D009101 Multiple Myeloma Curcumin 10.8819372569
MESH:D009101 Multiple Myeloma Paclitaxel 10.8814749477
MESH:D009101 Multiple Myeloma trichostatin A 10.8818172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.5617962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.718888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.9517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0116810080
MESH:D009361 Neoplasm Invasiveness Curcumin 4.0318495463
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.1115867366
MESH:D009369 Neoplasms Fenretinide 4.8515958647 17353921
MESH:D009369 Neoplasms sodium arsenite 4.8511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3220056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.1712497104
MESH:D009389 Neovascularization, Pathologic arsenite 8.9715738583
MESH:D009389 Neovascularization, Pathologic Estradiol 8.9717289903
MESH:D009421 Nervous System Malformations Estradiol 8.3516427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.3514600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.2718462866
MESH:D009436 Neural Tube Defects sodium arsenite 6.5712854658
MESH:D009436 Neural Tube Defects Valproic Acid 6.578888407 16359493
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.3216303764
MESH:D009765 Obesity Clozapine 4.7219142110 18515891
MESH:D009765 Obesity Curcumin 4.7219297423
MESH:D010014 Osteolysis Paclitaxel 4.6315867366
MESH:D010024 Osteoporosis Curcumin 3.2518719352
MESH:D010051 Ovarian Neoplasms Curcumin 21.0919020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 21.0919401270
MESH:D010051 Ovarian Neoplasms Fenretinide 21.0916133793
MESH:D010051 Ovarian Neoplasms Paclitaxel 21.0911161223
MESH:D010051 Ovarian Neoplasms sodium arsenite 21.0915276417 17306315
MESH:D010051 Ovarian Neoplasms trichostatin A 21.0919331143
MESH:D010051 Ovarian Neoplasms U 0126 21.0916211241
MESH:D010190 Pancreatic Neoplasms Curcumin 8.1117440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms Fenretinide 8.1115580305
MESH:D010190 Pancreatic Neoplasms trichostatin A 8.1119294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3611578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.7412065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8912520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.1411550810
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2218163543
MESH:D011225 Pre-Eclampsia Zinc 3.9017114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.2911222880 11399792 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.2920603192
MESH:D055728 Primary Myelofibrosis trichostatin A 4.9017616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5720887781
MESH:D011471 Prostatic Neoplasms Curcumin 2.0518226269 10851300 18156803 18769126 12497104 11398177 15129424
MESH:D011471 Prostatic Neoplasms Estradiol 2.0516740699
MESH:D011471 Prostatic Neoplasms Fenretinide 2.0517024972
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.0516356831 17136230 17172428 16729912
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0516039940
MESH:D011471 Prostatic Neoplasms trichostatin A 2.0518798265 19789329
MESH:D011471 Prostatic Neoplasms Zinc 2.0512429649 16700911 16517595 16606632
MESH:D011537 Pruritus Ethinyl Estradiol 2.9616919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.1811422049 12752131
MESH:D011595 Psychomotor Agitation Haloperidol 4.6111575062
MESH:D011618 Psychotic Disorders Clozapine 8.3115331141
MESH:D011618 Psychotic Disorders Haloperidol 8.3111575062
MESH:D011656 Pulmonary Emphysema Curcumin 4.2219168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.7018379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5018990726
MESH:D012162 Retinal Degeneration Fenretinide 8.5116303925
MESH:D012162 Retinal Degeneration Zinc 8.5116584753
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.8519155313
MESH:D012509 Sarcoma Curcumin 3.8118462866
MESH:D012559 Schizophrenia Clozapine 5.3518806925 20452607 11151749 18855531 16141801 20521326 17667964 20580759 20107430 17726453 20521320 19369910 20168265 17123785 11763009
MESH:D012559 Schizophrenia Haloperidol 5.3519369910 18513383 1830565 20107430
MESH:D012559 Schizophrenia Valproic Acid 5.3515737665 19110320
MESH:D012640 Seizures Valproic Acid 2.511511512 15475178 11044598 17978042 3137016 16876388 11738929 14763951
MESH:D018805 Sepsis Curcumin 3.7918389075
MESH:D012852 Sinusitis Phenylephrine 4.357327846
MESH:D012878 Skin Neoplasms Fenretinide 12.2016467112
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 12.2012065085
MESH:D012878 Skin Neoplasms sodium arsenite 12.2019524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.2016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5816709447
MESH:D016135 Spinal Dysraphism sodium arsenite 8.6412854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.6419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.1812833885
MESH:D013274 Stomach Neoplasms Paclitaxel 2.4418506536 18396642
MESH:D013276 Stomach Ulcer Curcumin 3.1916631530 19188055
MESH:D013576 Syndactyly methoxyacetic acid 5.291761404 1761407
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.3720210726
MESH:D024801 Tauopathies Paclitaxel 4.4616930453
MESH:D013733 Testicular Diseases methoxyacetic acid 4.9818486176 6499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5412697716
MESH:D013978 Tibial Fractures Estradiol 4.3219048282
MESH:D014062 Tongue Neoplasms Zinc 4.0916543248
MESH:D014178 Translocation, Genetic Valproic Acid 4.8717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.173119515
MESH:D001749 Urinary Bladder Neoplasms Curcumin 7.6718593936
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 7.6716720286
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.6711723127 17306315 16452187 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.308888407
MESH:D014565 Urogenital Neoplasms Curcumin 4.9118462866
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 8.7216154183
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.7211813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.5714692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 8.5718645019
MESH:D014652 Vascular Diseases sodium arsenite 4.0717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8915886252
MESH:D015430 Weight Gain Clozapine 4.1720564506 20107430 16141801 17502770 20521320 16402076
MESH:D015431 Weight Loss Clozapine 4.7217933447
Pathway ID Pathway Name
KEGG:05213 Endometrial cancer
KEGG:04012 ErbB signaling pathway
KEGG:04510 Focal adhesion
KEGG:04912 GnRH signaling pathway
KEGG:04910 Insulin signaling pathway
KEGG:05140 Leishmaniasis
KEGG:04010 MAPK signaling pathway
KEGG:05020 Prion diseases
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27749
    • No data
    No data
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    PA449972imiquimod
    PA164743471adenosine triphosphate
    PA448976choline
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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