AutismKB 2.0

Annotation Detail for ELN


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Basic Information Top
Gene Symbol:ELN ( FLJ38671,FLJ43523,SVAS,WBS,WS )
Gene Full Name: elastin
Band: 7q11.23
Quick LinksEntrez ID:2006; OMIM: 130160; Uniprot ID:ELN_HUMAN; ENSEMBL ID: ENSG00000049540; HGNC ID: 3327
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04974Protein digestion and absorption
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1990Skin disease, Genetic
1770Melanoma
1801Intracranial aneurysm
1804Chronic obstructive airway disease
1806Arteriopathy
1836Panic disorder
1872Chronic simple glaucoma
1891Ptosis
1940Ovarian disease
1992Aortic valve disease
2120Rabies
2145Subarachnoid hemorrhage
Desease Name
emphysema
Pulmonary Disease, Chronic Obstructive
CARDIOVASCULAR
Subarachnoid Hemorrhage
carotid artery distensibility
supravalvular aortic stenosis
brain aneurysm
No data
Desease Name
Supravalvar aortic stenosis
Cutis laxa, AD
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C000188 alachlor alachlor results in increased expression of ELN mRNAincreases expression 12419858
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ELN mRNAaffects cotreatment|increases expression 18164116
C006780 bisphenol A bisphenol A results in increased expression of ELN mRNAincreases expression 20739668
D002084 Butylated Hydroxytoluene [Oxygen co-treated with Butylated Hydroxytoluene] results in increased expression of ELN mRNAaffects cotreatment|increases expression 10761639
D004041 Dietary Fats Dietary Fats results in increased expression of ELN mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ELN mRNAaffects cotreatment|increases expression 18164116
D004317 Doxorubicin Doxorubicin affects the expression of ELN mRNAaffects expression 15205334
D005472 Fluorouracil Fluorouracil affects the expression of ELN mRNAaffects expression 15205334
D005480 Flurbiprofen Flurbiprofen results in decreased expression of ELN mRNAdecreases expression 16949054
C010176 halofuginone halofuginone results in increased expression of ELN mRNAincreases expression 17180598
C029938 nickel sulfate nickel sulfate results in increased expression of ELN mRNAincreases expression 16100012
C007350 nitrofen nitrofen results in decreased expression of ELN mRNAdecreases expression 15136996
11329586
C007350 nitrofen nitrofen results in decreased expression of ELN proteindecreases expression 15136996
C007350 nitrofen nitrofen results in increased expression of ELN mRNAincreases expression 10359170
D005996 Nitroglycerin Nitroglycerin results in increased expression of ELN mRNAincreases expression 12187120
D026423 S-Nitroso-N-Acetylpenicillamine S-Nitroso-N-Acetylpenicillamine results in decreased expression of ELN mRNAdecreases expression 12102619
D010100 Oxygen [Oxygen co-treated with Butylated Hydroxytoluene] results in increased expression of ELN mRNAaffects cotreatment|increases expression 10761639
D010126 Ozone Ozone results in increased expression of ELN mRNAincreases expression 7840908
C041786 palm oil palm oil results in increased expression of ELN mRNAincreases expression 18042831
D010269 Paraquat Paraquat results in increased expression of ELN mRNAincreases expression 17215068
D012176 Retinoids Retinoids analog results in increased expression of ELN proteinincreases expression 16055107
C507164 seletinoid G seletinoid G results in increased expression of ELN proteinincreases expression 16055107
C017947 sodium arsenite sodium arsenite results in decreased expression of ELN mRNAdecreases expression 18812580
C017947 sodium arsenite sodium arsenite results in increased expression of ELN mRNAincreases expression 19095001
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ELN mRNAincreases expression 18178546
D014192 Trapidil Trapidil affects the reaction [PTH protein affects the expression of ELN mRNA]affects expression|affects reaction 18635661
D014212 Tretinoin Tretinoin results in increased expression of ELN mRNAincreases expression 16033655
D014801 Vitamin A Vitamin A results in increased expression of ELN mRNAincreases expression 17426644
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6611752688 15322242 14514962
MESH:D000015 Abnormalities, Multiple Vitamin A 4.6910992263
MESH:D055371 Acute Lung Injury nickel sulfate 9.0716100012 19131640 12718980 11954676
MESH:D055371 Acute Lung Injury Oxygen 9.0716759491
MESH:D000230 Adenocarcinoma Doxorubicin 4.4517418594
MESH:D000230 Adenocarcinoma Fluorouracil 4.4517638652
MESH:D000236 Adenoma beta-Naphthoflavone 6.5219389873
MESH:D000236 Adenoma Diethylnitrosamine 6.5210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.4117620307 19052882 19061943 16434500 18056438 17162532
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.4116835633
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 4.9010680582
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7116712894 17306315
MESH:D000382 Agricultural Workers' Diseases alachlor 8.4414769641 11874814
MESH:D000382 Agricultural Workers' Diseases Paraquat 8.4411874814
MESH:D000419 Albuminuria Doxorubicin 4.3621441931
MESH:D000505 Alopecia Tretinoin 3.4615955085
MESH:D000544 Alzheimer Disease Ozone 2.4015513908
MESH:D000740 Anemia Fluorouracil 13.9517963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 13.9511748828
MESH:D000740 Anemia Vitamin A 13.9516960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.6316960172
MESH:D000860 Anoxia Oxygen 4.8620872349
MESH:D021921 Aortic Stenosis, Supravalvular marker/mechanism 20007321
MESH:D001161 Arteriosclerosis Dietary Fats 3.7015238619
MESH:D001169 Arthritis, Experimental Tretinoin 2.9616412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.5115570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.5116292516
MESH:D001249 Asthma Ozone 7.7017854713 16373670
MESH:D001249 Asthma Tretinoin 7.7016456186
MESH:D001249 Asthma Vitamin A 7.7016732791
MESH:D050197 Atherosclerosis Oxygen 3.6916391483
MESH:D001471 Barrett Esophagus Tretinoin 4.2216935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.3616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5114601052
MESH:D001862 Bone Resorption bisphenol A 3.6911985600
MESH:D001932 Brain Neoplasms Doxorubicin 3.6417150277
MESH:D001943 Breast Neoplasms bisphenol A 5.6517123778
MESH:D001943 Breast Neoplasms Dietary Fats 5.6520435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.6517474063
MESH:D001943 Breast Neoplasms Doxorubicin 5.6515136595 17369602 18695136 16322301 18628466 16115903 15939500 17426702 16096432 18382427 16264153 17983394 18234424 16595493 19526202 15567936 15993339 15668708 11325840 16935488 16826403 15692762 15634643 15994142
MESH:D001943 Breast Neoplasms Fluorouracil 5.6516110121 18608205 15136595 18357371 19217205 16557594 16595493
MESH:D001943 Breast Neoplasms Oxygen 5.6517263869
MESH:D001943 Breast Neoplasms Retinoids 5.6517368321 19340624 17491551
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.6520435547
MESH:D001943 Breast Neoplasms Tretinoin 5.6516443354 16873071 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5315516495 19059883 16777450 18315731 14754758 17626835 18417511
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 12.3816813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 12.3817377406 17426644
MESH:D002100 Cachexia Ozone 4.5516183385
MESH:D002276 Carcinoid Tumor Doxorubicin 11.7116051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.7116051944
MESH:D002277 Carcinoma Fluorouracil 7.6917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9716168501
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.5517761372 19394651 16935385 16698587 20214788 20512989 3084413 16830150 19919837 11831363 18210153 17428255 19701751 19418558 19052882 16540662 18506893 16288022 17055752 17173139 16569478 18665156 20727157 18785209 18393292 16807293 19208518 19335982 10672840 17978847 18691550 17138121 17162532 10737359 20514400 19822196 19383236 18978308 18788625 21159647 16328049 16779866 18056438 20935162 16502159 19519916 16681979 20524982 20101231 20007298 19107877 19539802 16878318 19171122 20432363 3581430 18494052 18971187 20084675
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.5516023760 16234567 17876044 18059187
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.5516799960 17088986 16332177 18930000 17045692 17971768
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.5517306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.551917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.8017123778
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.3816201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.3818695887
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.356189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.3516757204 18986760 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.3518572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.3516096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2618670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.4116455267 17519947 17007740 16731534 17924179 16109756 16612575 16364871 15811867 15505089 16278810 17308081 16952015 16651473 17928571 17131338 16242529 17329180 17974986 15476868 15792986 16269455 17382496 18627295 17351982
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8817334414 16243910
MESH:D002386 Cataract Tretinoin 2.9817460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.3421159647 2727394 17174075 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.3419524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4016129372
MESH:D015362 Child Nutrition Disorders Vitamin A 5.2816153327
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7916835633
MESH:D002779 Cholestasis Vitamin A 4.1616175620
MESH:D002822 Choriocarcinoma Tretinoin 4.9716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.4512621046 15668235 16354765 15340226 8697196
MESH:D002972 Cleft Palate Tretinoin 9.459407595
MESH:D002972 Cleft Palate Vitamin A 9.4516054864
MESH:D003092 Colitis Tretinoin 3.5217035595
MESH:D003110 Colonic Neoplasms Fluorouracil 4.0117169374 16510598 17016597 17725105 18772588 15001691 17018589 17172411 16340194 17287894
MESH:D003110 Colonic Neoplasms Vitamin A 4.0117219422 16267017
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.6018259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6018288408 15148649 17016601 17695437 18448328 18383874 17094418 18802399 17255274 16282729 14970324 16303861 17401013 16524972 18949393 18509181 17594712 17454858 16331619 20501625 15289873 16391804
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9017141729 14669216
MESH:D019465 Craniofacial Abnormalities nitrofen 5.3311405365
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.3320055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.3310589399 14991402 17551590 9211117 9142499 9125849 8800419 9224671 9664655 16925845
MESH:D019465 Craniofacial Abnormalities Vitamin A 5.3310992263
OMIM:123700 CUTIS LAXA, AUTOSOMAL DOMINANT marker/mechanism
MESH:D007644 Darier Disease Fluorouracil 4.6016733453
MESH:D017449 Dermatitis, Allergic Contact alachlor 7.038428444
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 7.0316823706 16780908 11298694
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.4516506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0617107852
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.9119107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 5.9117416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.9120420201
MESH:D004362 Drug Toxicity Doxorubicin 7.6418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.6411462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.6116146918
MESH:D050171 Dyslipidemias Dietary Fats 3.3218367378
MESH:D004417 Dyspnea Oxygen 4.6420016425
MESH:C538011 Eales disease Vitamin A 5.439068938
MESH:D004480 Ectromelia Vitamin A 5.6316054864
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.3015322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.3018230668
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.1817359293
MESH:D016889 Endometrial Neoplasms Tretinoin 7.1816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.869294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9618037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4016481741 15173087 17638652 16337965 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.3716938888 9664655
MESH:D015785 Eye Diseases, Hereditary Retinoids 5.7716968212
MESH:D005234 Fatty Liver Dietary Fats 7.2817967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 7.2821071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005327 Fetal Resorption Vitamin A 5.1716054864
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4019069698
MESH:D005355 Fibrosis Dietary Fats 13.6718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.6720067830
MESH:D005355 Fibrosis Tretinoin 13.6717994277
MESH:D005739 Gas Poisoning Oxygen 5.0320016425
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4916452187
MESH:D005909 Glioblastoma Doxorubicin 6.8317150277
MESH:D005909 Glioblastoma Tretinoin 6.8317312396
MESH:D005910 Glioma Fluorouracil 2.7916145905
MESH:D005911 Gliosis Paraquat 4.9711124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006261 Headache Nitroglycerin 5.0011284996 11554966
MESH:D006258 Head and Neck Neoplasms Doxorubicin 17.4915692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 17.4915102660 18337622 15162350
MESH:D006258 Head and Neck Neoplasms Retinoids 17.4917368321
MESH:D006258 Head and Neck Neoplasms Tretinoin 17.4916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9716084493
MESH:D006330 Heart Defects, Congenital nitrofen 15.2716080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 15.2710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 15.2714991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin A 15.2710992263 16080930
MESH:D006331 Heart Diseases Doxorubicin 3.3517875725 12587719 16879835 16144979 14766674 18674790 16244372 17888722 16330681 16244371 16495754 16707910 18006777
MESH:D006333 Heart Failure Doxorubicin 3.2317481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7315692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7112621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic marker/mechanism 10359170
MESH:D006548 Hernia, Diaphragmatic nitrofen 6.4110646786 16720372 10370017 10693666 10359170 12021965 17270546 12759764 9575882 15578192 9473106 9859898 15707848 18280292 9476886 10898224 7576705 11584395 16863852 15088113 10898222 17245593 12746050 15136996 17618886 11076806 9698600 11329586 18280291 15185205 10541330 11057544 16292651 12505043 15764645 15756563 11051153 18958481 11685700 10370016 12194112 16490937 16080930 11409163 7760232 12407540 11588001 7520565 12547725 15793718 16473863 12904592 8863223
MESH:D006548 Hernia, Diaphragmatic Vitamin A 6.4116863852 16292552 15707848 17436238 16877224 16490937
MESH:D015658 HIV Infections Vitamin A 3.7216960176
MESH:D006679 HIV Seropositivity Vitamin A 5.4117209195
MESH:D006689 Hodgkin Disease Doxorubicin 6.9517606976 18501091 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 6.9512676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8518606429 16354765 16959395 15340226 8697196
MESH:D006930 Hyperalgesia Tretinoin 3.0616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4221332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3816778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.4421332399
MESH:D006965 Hyperplasia halofuginone 5.0611874485
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.3417604070
MESH:D006973 Hypertension marker/mechanism 17039479
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8418850075 18670907
MESH:D006986 Hypervitaminosis A Vitamin A 5.9816054864
MESH:D007248 Infertility, Male alachlor 10.7317049205 16466525 12948887
MESH:D007248 Infertility, Male Paraquat 10.734850670
MESH:D007248 Infertility, Male sodium arsenite 10.7312646999 15346721
MESH:D007249 Inflammation Dietary Fats 11.2020412841
MESH:D007249 Inflammation Diethylnitrosamine 11.2018785209
MESH:D007249 Inflammation Flurbiprofen 11.2011099482
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.2012878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 7.0816393666
MESH:D007333 Insulin Resistance Dietary Fats 7.0818457598 11836018
MESH:D007410 Intestinal Diseases Tretinoin 3.5817994277
MESH:D019586 Intracranial Hypertension Vitamin A 5.6315955940
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3616580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3615992940 17551590
MESH:D007674 Kidney Diseases Doxorubicin 5.9216775033 15369732 15699352
MESH:D007674 Kidney Diseases sodium arsenite 5.9220008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.9816707910
MESH:D007680 Kidney Neoplasms Fluorouracil 3.1516985049
MESH:D007938 Leukemia alachlor 6.4614769641
MESH:D007938 Leukemia Tretinoin 6.4617143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9616085563
MESH:D007951 Leukemia, Myeloid Retinoids 9.5316482212
MESH:D007951 Leukemia, Myeloid Tretinoin 9.5316482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0517596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0317649720 19642359 19225113 16331271 16891316 17294898 12679006 9834237 16823087 19075265 19029980 16788101 16935935 17107899 16140955 19035177 17217047 16766008 17368321 15748426 17301526 17339181 17506722 17361223 17712046
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.059224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 8.0516054864
MESH:D008103 Liver Cirrhosis Dietary Fats 15.0118296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 15.0118665156 18407596 18522880 19638242 20032147
MESH:D008103 Liver Cirrhosis halofuginone 15.0117180598
MESH:D008103 Liver Cirrhosis Vitamin A 15.0116256175
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.5216439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 6.5211172339 12175628 18458672 16489207 14739098
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.5216248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 6.5216248980
MESH:D008107 Liver Diseases Diethylnitrosamine 4.3017034775
MESH:D008107 Liver Diseases Vitamin A 4.3016175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.9716762690
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 17.0519389873 21295105
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 17.0518177683
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.0515885732 20405173 20118626 19996281 18978307 20137499 20501860 20492335 19090486 21047994 19812893 20434301 19294768 19427195 18644402 21167192 18977376 19073162 18754104 19256749 19499222 2862719 18648771 2422723 20101389 19642983 21278145 19551842 19638242 19255062 20452335 19690152 19254457 12112319 15175105 16942905 19426721 20583210 12771043 10737359 9163691 19850985 21071580 19833225
MESH:D008113 Liver Neoplasms Fluorouracil 17.0518383874 16603448 17045692 15113037
MESH:D008113 Liver Neoplasms sodium arsenite 17.0516712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.0516984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 17.4218164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.4218164116 18544905 19519916 18775883 16842330 18079962 18282651 16267830 17942915 19539802 18253720 19004024 2563599 21159647 9362446 17174075 18308698 19009564 3124819 19126423 17854601 18093689
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 17.4216842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.4212151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 17.4217113696
MESH:D008171 Lung Diseases nitrofen 16.6617245593 16863852 9614859 9859898
MESH:D008171 Lung Diseases Ozone 16.6619066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 16.6619095001
MESH:D008171 Lung Diseases Vitamin A 16.6616863852
MESH:D055370 Lung Injury Oxygen 8.8018339021
MESH:D055370 Lung Injury Ozone 8.8020417186
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 10.3419925653 11696405 18597497 19359593 11246140 16337739 15390079
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.3420970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 10.3417418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 10.3415246190
MESH:D008175 Lung Neoplasms Ozone 10.348597069 7614698
MESH:D008175 Lung Neoplasms sodium arsenite 10.3416712894 19931552 17306315 15276417 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.3411884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6015086387
MESH:D008223 Lymphoma Doxorubicin 3.3316098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3815621674
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 6.151500032
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.1515458769
MESH:D008415 Mastocytosis Retinoids 6.3916953078
MESH:D008527 Medulloblastoma Tretinoin 2.7117453147
MESH:D008545 Melanoma Doxorubicin 4.9516827129
MESH:D008545 Melanoma sodium arsenite 4.9516487513 19082730
MESH:D008545 Melanoma Tretinoin 4.9516752155
MESH:D008591 Meningomyelocele Tretinoin 4.2416940565
MESH:D008654 Mesothelioma Doxorubicin 2.9817638057
MESH:D008679 Metaplasia Ozone 4.9110496685
MESH:D008708 Methemoglobinemia Nitroglycerin 4.563537620
MESH:D020326 Migraine without Aura Nitroglycerin 4.9414659530
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3215792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4916757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.6017415656
MESH:D009101 Multiple Myeloma alachlor 7.6214769641
MESH:D009101 Multiple Myeloma Vitamin A 7.6216374440
MESH:D020391 Muscular Dystrophy, Facioscapulohumeral marker/mechanism 12868502
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9717596541
MESH:D009203 Myocardial Infarction Doxorubicin 6.0519429709 15857846
MESH:D009203 Myocardial Infarction Nitroglycerin 6.0514729435
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.633581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.6318259882
MESH:D009369 Neoplasms Fluorouracil 7.7818600527 16928823 18239605
MESH:D009369 Neoplasms sodium arsenite 7.7811559025
MESH:D009369 Neoplasms Tretinoin 7.7816946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4820056578
MESH:D009401 Nephrosis Doxorubicin 4.5816899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8415640375 16889571
MESH:D009410 Nerve Degeneration Paraquat 3.5716893418
MESH:D009421 Nervous System Malformations bisphenol A 15.3111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.3114600291
MESH:D009421 Nervous System Malformations Tretinoin 15.319125849
MESH:D009436 Neural Tube Defects sodium arsenite 11.5712854658
MESH:D009436 Neural Tube Defects Tretinoin 11.579142499
MESH:D009436 Neural Tube Defects Vitamin A 11.5717400914
MESH:D009447 Neuroblastoma Doxorubicin 3.1715555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3116436463
MESH:D009669 Nose Neoplasms alachlor 4.6314563481 16698726 15580706 11127290 16178123
MESH:D009765 Obesity Dietary Fats 2.2411836018 20132043 19632207 17217161 16723640 21332399 20518802 18674790 18457598
MESH:D012516 Osteosarcoma Doxorubicin 3.9615930896
MESH:D010049 Ovarian Diseases bisphenol A 4.8011985600
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.6817306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 4.6816936753
MESH:D010146 Pain Tretinoin 2.7516870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.2316540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.2315113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.2315976015
MESH:D010300 Parkinson Disease Paraquat 2.7412911755 15824117 15451049 11124998 11445065 11181820 16510128 16140633
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.2416190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010538 Peritonitis Ozone 3.9416369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9617983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9617638057
MESH:D011014 Pneumonia Butylated Hydroxytoluene 17.5411893704
MESH:D011014 Pneumonia Ozone 17.5418381685 18929643 18007984
MESH:D011014 Pneumonia Paraquat 17.5412504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.392563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.8710548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.8711222880 11896295 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.0320887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.9016740699
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9015897917 18437689 16868541 16729912 15749863 16888761
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.9018626508 19082440
MESH:D011471 Prostatic Neoplasms Flurbiprofen 1.9017409433
MESH:D011471 Prostatic Neoplasms Retinoids 1.9016166285 16724957
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9016039940
MESH:D011507 Proteinuria Tretinoin 3.4316636307
MESH:D011625 Pterygium Tretinoin 4.6016723453
MESH:D011629 Puberty, Precocious bisphenol A 4.5910548101
MESH:D011658 Pulmonary Fibrosis marker/mechanism 10761639
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8416324872 17997886
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8515538739 18286688 16160472 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 4.0317922066
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 8.8517627322 18339021
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 8.8511700416
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.6116877224
MESH:D012135 Respiratory Sounds alachlor 9.4311874814
MESH:D012135 Respiratory Sounds Paraquat 9.4311874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012162 Retinal Degeneration Paraquat 3.7316458197
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9216116481 16283617
MESH:D012509 Sarcoma Doxorubicin 3.8217710206 17203757 15625365 18313854 16767912 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.0614601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6017846226
MESH:D012871 Skin Diseases halofuginone 5.4911874485
MESH:D012871 Skin Diseases Vitamin A 5.4918709164
MESH:D012878 Skin Neoplasms Doxorubicin 17.0115692506
MESH:D012878 Skin Neoplasms Retinoids 17.0117538947
MESH:D012878 Skin Neoplasms sodium arsenite 17.0118572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 17.0116192470
MESH:D012878 Skin Neoplasms Tretinoin 17.0116467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3817203757 16767912 15625365
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6512854658
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2818456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.2818567086 16424979 17172411 18396642 19084572 17522103 16951190 19015929 17498489 15786421
MESH:D013274 Stomach Neoplasms Tretinoin 3.2817261132
MESH:D019966 Substance-Related Disorders bisphenol A 3.7916045194 16684133
MESH:D013398 Sudden Infant Death Oxygen 5.3512563064
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms alachlor 20.998812207
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 20.997505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 20.9916010429 17909728
MESH:D013964 Thyroid Neoplasms Retinoids 20.9916940797
MESH:D013964 Thyroid Neoplasms Tretinoin 20.9916026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 9.2716280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.2716051514
MESH:D014376 Tuberculosis Tretinoin 3.1116040207
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.0217653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.0217306315 11723127 16712894 16452187
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.8916803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.8911813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.8916129372
MESH:D014591 Uterine Diseases bisphenol A 4.8214652134
MESH:D014604 Uveal Neoplasms Tretinoin 4.4216752155
MESH:D014652 Vascular Diseases sodium arsenite 4.2317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0317334414 16364871 17638931 17678736
MESH:D014802 Vitamin A Deficiency Vitamin A 5.1016960172 16146918 16175781
MESH:D014820 Vitiligo Tretinoin 3.8716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D015430 Weight Gain Dietary Fats 3.5816723640
MESH:D018980 Williams Syndrome marker/mechanism
MESH:D009396 Wilms Tumor Tretinoin 3.8116287080
Pathway ID Pathway Name
KEGG:04974 Protein digestion and absorption
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27757
    • No data
    No data
    Releated drug ID Related drug Name
    PA452347glucocorticoids
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00533 other/unknown Rofecoxib Cyclooxygenase Inhibitors;Cyclooxygenase 2 Inhibitors
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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