AutismKB 2.0

Annotation Detail for SPRED2


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Basic Information Top
Gene Symbol:SPRED2 ( FLJ21897,FLJ31917,MGC163164,Spred-2 )
Gene Full Name: sprouty-related, EVH1 domain containing 2
Band: 2p14
Quick LinksEntrez ID:200734; OMIM: 609292; Uniprot ID:SPRE2_HUMAN; ENSEMBL ID: ENSG00000198369; HGNC ID: 17722
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04630Jak-STAT signaling pathway
No data
Pathway IDPathway Name
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2022Liver cancer
No data
Desease Name
Rheumatoid arthritis
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SPRED2 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SPRED2 proteinaffects expression 20106945
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of SPRED2 mRNAaffects expression 17331233
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SPRED2 mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SPRED2 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of SPRED2 mRNAincreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of SPRED2 mRNAincreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of SPRED2 mRNAdecreases expression 15171707
D004958 Estradiol Estradiol results in decreased expression of SPRED2 mRNAdecreases expression 20068009
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of SPRED2 mRNAincreases expression 20713471
C006253 pirinixic acid pirinixic acid results in decreased expression of SPRED2 mRNAdecreases expression 17950772
C066075 vanadium pentoxide vanadium pentoxide affects the expression of SPRED2 mRNAaffects expression 17459161
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Estradiol 2.1311473722
MESH:D000236 Adenoma Methylcholanthrene 3.576695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6415469931
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001172 Arthritis, Rheumatoid marker/mechanism 20453842
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5311922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0317129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 2.0312948864 18497071 16675129 17289903 19861407 17261762 14630087 17018787
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.0317474063
MESH:D001991 Bronchitis vanadium pentoxide 6.4617459161
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002277 Carcinoma Methylcholanthrene 4.0810545420
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.743084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7421507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.7415948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7416924424
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.8420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.8412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.8418566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 16.8416192471
MESH:D002779 Cholestasis Cyclosporine 8.1019486331
MESH:D002779 Cholestasis pirinixic acid 8.1019176532
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.7216002989 12952375
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6218713872 19739265 16485898 17906064 17562736 16109766 12392966 12540782 16393943 14725611 19164858 14550746 19420014 16177239 15619225 16781746 19370779 11287661 17522070 10915739 12594235 12153990 2444490 12958197 15968718 12705907 10774834 10663392 19923254 11834606 11739529 16227642 11529661 11743745 16081117 19085960 11461765 18071297 19416960 14986274 11421492
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.8916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.8416804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 7.8419148513 18566989 11473722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005234 Fatty Liver Cyclosporine 8.0319224547
MESH:D005234 Fatty Liver pirinixic acid 8.0320131406 19236843
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7316534752 16002989 16611131 16513791 15751030
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.1310962813 14633661
MESH:D005355 Fibrosis Cyclosporine 3.3212168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.1416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006529 Hepatomegaly pirinixic acid 3.1718467677 19176532 19772884 16221962
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.6112960047 14722030
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D007021 Hypospadias Diethylstilbestrol 4.7516002989
MESH:D007246 Infertility Diethylstilbestrol 4.5215036965
MESH:D007333 Insulin Resistance Estradiol 7.4916627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.4916306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 10.4212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.428314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 10.4215618244
MESH:D007680 Kidney Neoplasms Cyclosporine 13.1312371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 13.1316762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 13.1315610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.2417184923
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3315474484
MESH:D008107 Liver Diseases Acetaminophen 1.6612587719 16611625 19460945 16610002 12969438 11587558 19014921 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.7615890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.7616712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 7.7620007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.518603461
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 6.51598648 1399818
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.2017365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.8214755239
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.8221163286 10545420 15390079 20970405 16337739 1399818 16271038 9230183 17909032 7750092 11893704 20512841 6695378
MESH:D008175 Lung Neoplasms vanadium pentoxide 3.8212376484
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3415166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5715700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.7316002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6417203775 16891317 11408345 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2316166281 18303189 16966607
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6116411023
MESH:D009369 Neoplasms Diethylstilbestrol 5.2515313581
MESH:D009369 Neoplasms pirinixic acid 5.2517405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4118481113 19348381
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.3511399458
MESH:D009421 Nervous System Malformations Estradiol 10.3516427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8516977796 15687265
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.0710923243
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.3117184923
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.2917136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 3.2916740699
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0717975199 17365031 15814490 17322281
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.758532709
MESH:D013088 Spermatocele Diethylstilbestrol 4.9316002989 16709447
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 2.8217306315 16712894 16452187
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.1616175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.3914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.2316690809 15809267
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6116513791 16002989
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:04630 Jak-STAT signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134956365
    • No data
    No data
    Releated drug ID Related drug Name
    PA10804imatinib
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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