AutismKB 2.0

Annotation Detail for LIPH


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Basic Information Top
Gene Symbol:LIPH ( AH,ARWH2,LAH2,LPDLR,PLA1B,mPA-PLA1 )
Gene Full Name: lipase, member H
Band: 3q27.2
Quick LinksEntrez ID:200879; OMIM: 607365; Uniprot ID:LIPH_HUMAN; ENSEMBL ID: ENSG00000163898; HGNC ID: 18483
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
P057262-arachidonoylglycerol biosynthesis
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2230Alopecia
No data
No data
Desease Name
Woolly hair, autosomal recessive 2 with or without hypotrichosis
Hypotrichosis, localized, autosomal recessive 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D005472 Fluorouracil Fluorouracil results in decreased expression of LIPH mRNAdecreases expression 16709241
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LIPH mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.7311752688 15322242 14514962
MESH:D000230 Adenocarcinoma Fluorouracil 2.5117638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.2616835633
MESH:D000740 Anemia Fluorouracil 10.4117963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 10.4111748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.8615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0515746008
MESH:D001943 Breast Neoplasms Fluorouracil 2.0218608205 16595493 15136595 16110121 19217205 18357371 16557594
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002276 Carcinoid Tumor Fluorouracil 5.7416051944
MESH:D002277 Carcinoma Fluorouracil 9.5717121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.5716835633
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1217971768 16332177 17088986 17045692 16799960 18930000
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.2018695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5917066447 16757204 18986760 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.6018850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.6316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2615668235 15340226 12621046 16354765 8697196
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2918772588 15001691 17169374 17725105 17172411 16510598 17287894 17018589 16340194 17016597
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0118509181 16524972 18383874 18448328 17695437 17255274 17401013 18288408 20501625 14970324 16331619 16282729 15148649 17016601 17454858 17094418 18802399 18949393 16303861 15289873 16391804 17594712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.5317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2720055451 10048152 15322242
MESH:D007644 Darier Disease Fluorouracil 5.6816733453
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7517107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.1211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.9211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.9718230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.5310568697 9294722
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5417638652 16337965 16785472 16481741 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3811564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.2211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.7120067830
MESH:D005910 Glioma Fluorouracil 3.0216145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.6610696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.7015102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5511294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.6515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 5.128697196 16959395 15340226 18606429 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0418850075 18670907
OMIM:604379 HYPOTRICHOSIS, LOCALIZED, AUTOSOMAL RECESSIVE 2 marker/mechanism
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0612878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8916580747
MESH:D007680 Kidney Neoplasms Fluorouracil 3.7416985049
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Fluorouracil 4.9816603448 17045692 18383874 15113037
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.9816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3812151625
MESH:D008175 Lung Neoplasms Fluorouracil 2.4515246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4519555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.6815086387
MESH:D009062 Mouth Neoplasms Fluorouracil 4.0216757204 18986760
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.4312213967
MESH:D009369 Neoplasms Fluorouracil 2.8016928823 18600527 18239605
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.8914600291
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.7516436463
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7916929163 15113037 16500647 19003803
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.3212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.2318163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 4.0811222880 11896295 11118676 11399792
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3419082440 18626508
MESH:D012004 Rectal Neoplasms Fluorouracil 4.4815538739 18286688 18722050 16160472
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.5118990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2316192470
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0017522103 16951190 16424979 17172411 18396642 15786421 19084572 18567086 17498489 19015929
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.9712697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.5016280240
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.3816803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.3215886252
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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