AutismKB 2.0

Annotation Detail for RPL22L1


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Basic Information Top
Gene Symbol:RPL22L1 ( MGC104449 )
Gene Full Name: ribosomal protein L22-like 1
Band: 3q26.2
Quick LinksEntrez ID:200916; OMIM: NA; Uniprot ID:RL22L_HUMAN; ENSEMBL ID: ENSG00000163584; HGNC ID: 27610
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C013813 4-anisidine 4-anisidine results in decreased expression of RPL22L1 mRNAdecreases expression 12929121
D000082 Acetaminophen Acetaminophen affects the expression of RPL22L1 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RPL22L1 mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RPL22L1 mRNAaffects expression 17484886
D002995 Clofibric Acid Clofibric Acid affects the expression of RPL22L1 mRNAaffects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RPL22L1 mRNAaffects expression 17555576
D006918 Hydroxyurea Hydroxyurea results in decreased expression of RPL22L1 mRNAdecreases expression 12929121
D017239 Paclitaxel Paclitaxel results in decreased expression of RPL22L1 mRNAdecreases expression 12929121
D018038 Sodium Selenite Sodium Selenite results in increased expression of RPL22L1 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of RPL22L1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RPL22L1 mRNAincreases expression 15328365
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0411752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2820464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2814692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.7215867366
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9717474063 20146248
MESH:D001943 Breast Neoplasms Paclitaxel 1.9715136595 18223236 16244791 11325840 18234424 16273361 16115903 18323546
MESH:D001943 Breast Neoplasms Tamoxifen 1.9718855134 19084267 16273361 21138602 18425577 19115204 19244106 19189212 18821012 20135344 16818667 15565566 19288272 19189210 19066611 19200415 17242785 21152245 19059307 19410462 18984771 15668708 19103187 17261762 20065188 11161223 20859285 16873071 20390343 18351453 18629630 17440819 20005174 17049068 19289846 16202921 18997820 19011961 20544844 18815881 19487384 17893378 19155303 19142967 19221464
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9518705752 16192424 16011737 16050911 16124888 10355542 3786805 15700767 16097048 15721981 15673190 16227642
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6819066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.753084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7518788625
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 6.7516313753
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.7516924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9817333356 11677210 17110522 16919318 15861022 17681005 16105132
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1512621046 8697196 15668235 16354765 15340226
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4418802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5419031437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6019279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2716485898 18713872 19164858 12705907 10774834 16109766 12392966 11287661 12153990 14725611 15619225 10915739 11421492 10663392 17522070 11834606 16393943 19416960 19923254 11461765 14550746 19739265 17562736 16781746 19420014 12958197 12594235 16081117 19370779 18071297 11529661 16177239 15968718 14986274 12540782 19085960 2444490 11739529 16227642 17906064 11743745
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.277120509 16227642 6623471 4309450 7179309 2869522 3732212 9327722 15027814 7440962 3786805 19336974 15998439 11566570 21278145 15968718 6884620 16177239 10092053 17522070 10915739 19085960
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.2715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1216714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.4919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1317893378 19155303 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7616530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.7616481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.9316239168 17595544 15959796 12631006 19224547 16045604 12795759 61145
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.9315345470
MESH:D005234 Fatty Liver Tamoxifen 13.9319224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3819069698
MESH:D005355 Fibrosis Carbon Tetrachloride 9.1918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.1920067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0712621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Tamoxifen 5.1119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1112878042 12200463
MESH:D007333 Insulin Resistance Sodium Selenite 3.3614714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2715629191 12587719
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1618625569
MESH:D007951 Leukemia, Myeloid Hydroxyurea 5.1516532439
MESH:D008064 Lipidoses Tamoxifen 3.2517567588 15342952
MESH:D008080 Liposarcoma Paclitaxel 4.9717353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8821278145 16239168 17174718 11903743 16943688 17157831 11408273 16221502 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5218472332 14724832 17922224 17944888 17708605 16033810 17698563 18481824 14512876 16192424 14620537 18166357 16136751 15362042 15370692 17640975 18054572 18187930 17823541 18339082 15650968 12667390 16638106 16097048 18251166 15123356 17761835 12546737 18277467 17900296 18263696 17805973 12445418 17525996 16015684 17766677 14716496 17565644 17714472 17721639 14748882 13678700 12649538 18395914 17869086 18418968 15052691 10355542 15893842 18279442 15818738 16027843 18376398 18317297 18006644 15673190 15931870 12632514 17976157 18705752 15959796 15057751 16011737 15876570 12389079 18210741 15925388 16116963 18472094 12445421 12666154 18412020 17481882 18395095 12609069 11481614 18205269 14716833 12958196 15996030 17631135 20821823 15338365 18429990 16248980 12898905 18156304 17557913 18420326 15730626 12741479 12632512 12586293
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5212878042
MESH:D008107 Liver Diseases Acetaminophen 4.0012969438 16611625 11587558 16610002 19460945 19014921 12587719 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0015830285 15720792 17285989 16246199 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.8516899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.7621137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.7619294768
MESH:D008113 Liver Neoplasms Clofibric Acid 14.7617602206
MESH:D008113 Liver Neoplasms Tamoxifen 14.7616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.7616984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.0415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0412151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4217053015 18569708 20064080 6695378 20869020 18816296 18520028 20464547 20135361
MESH:D008175 Lung Neoplasms Tamoxifen 3.4218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4211884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.2114749477
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7114580682 16827153 11731420 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.7619453300
MESH:D008545 Melanoma Paclitaxel 3.5912040289 12025231 16342250
MESH:D008545 Melanoma Tamoxifen 3.5919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009101 Multiple Myeloma Paclitaxel 3.7814749477
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.1515867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.1519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2219196722 19189210 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D010014 Osteolysis Paclitaxel 5.1715867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0311161223
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0817292933
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.0817136230 17172428 16356831 16729912
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.0818760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0815067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.5115861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.3016709447
MESH:D013088 Spermatocele Tamoxifen 12.3016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2319457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.612093021 20155912
MESH:D013274 Stomach Neoplasms Paclitaxel 2.6118396642 18506536
MESH:D024801 Tauopathies Paclitaxel 5.0116930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1617053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.1617572228 16712894 8653321
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6815869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:03010 Ribosome
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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