AutismKB 2.0

Annotation Detail for SLC39A11


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Basic Information Top
Gene Symbol:SLC39A11 ( C17orf26,ZIP11 )
Gene Full Name: solute carrier family 39 (metal ion transporter), member 11
Band: 17q24.3-q25.1
Quick LinksEntrez ID:201266; OMIM: NA; Uniprot ID:S39AB_HUMAN; ENSEMBL ID: ENSG00000133195; HGNC ID: 14463
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
Amyotrophic Lateral Sclerosis
NEUROLOGICAL
Desease Name
Amyotrophic lateral sclerosis
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SLC39A11 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SLC39A11 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC39A11 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLC39A11 mRNAdecreases expression 20106945
20064835
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in increased expression of SLC39A11 mRNAincreases expression 19925653
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SLC39A11 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SLC39A11 mRNAaffects cotreatment|decreases expression 17942748
D013629 Tamoxifen Tamoxifen affects the expression of SLC39A11 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SLC39A11 mRNAaffects cotreatment|decreases expression 17942748
D014303 Trinitrotoluene Trinitrotoluene affects the expression of SLC39A11 mRNAaffects expression 21346803
D015032 Zinc SLC39A11 protein results in increased transport of Zincincreases transport 18326752
D015032 Zinc SLC39A11 protein results in increased uptake of Zincincreases uptake 17126599
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.3715322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 9.377525203
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000169 Acrodermatitis Zinc 5.6417202136 17190629 16889938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3020464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3014692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000544 Alzheimer Disease Zinc 2.7916325427 17119284 16580781 16410023
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000755 Anemia, Sickle Cell Zinc 5.1016916123
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001249 Asthma Zinc 3.0017085522
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001930 Brain Injuries Zinc 4.9017109824
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7920146248 17474063
MESH:D001943 Breast Neoplasms Tamoxifen 1.7918821012 17261762 18425577 21138602 19289846 19103187 19142967 21152245 16202921 19410462 20544844 16273361 20065188 16873071 16818667 17893378 11161223 19084267 18997820 19059307 15565566 19200415 18629630 17242785 20005174 20390343 18984771 20859285 20135344 19244106 18351453 19011961 19155303 17440819 18855134 19189212 19066611 19189210 15668708 19115204 19288272 17049068 19487384 18815881 19221464
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7716705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7721507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.7716924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9420419170
MESH:D002294 Carcinoma, Squamous Cell Zinc 4.9416543248
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Zinc 3.7716936243
MESH:D002386 Cataract Trinitrotoluene 3.9615817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.886135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0016919318 17110522 17333356 17681005 11677210 15861022 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615340226 16354765 15668235 8697196 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.7917141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 9.7915095906
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7115322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Zinc 2.7119302082
MESH:D003490 Cyanosis 2,4-dinitrotoluene 20.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 20.1218551238
MESH:D003490 Cyanosis Trinitrotoluene 20.1218551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003920 Diabetes Mellitus Zinc 4.3616479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6319279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.3818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.3818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3820420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 9.3818551238 21346803
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.6212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.6219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1516202921 20544844 17893378 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7716530937
MESH:D004938 Esophageal Neoplasms Zinc 4.7716543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.2715345470
MESH:D005234 Fatty Liver Tamoxifen 8.2714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005756 Gastritis Zinc 5.0617241300
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006130 Growth Disorders Zinc 4.0717217573
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7210048152 11294989
MESH:D006333 Heart Failure Zinc 3.7117162251
MESH:D006335 Heart Injuries Zinc 6.0317074742
MESH:D016481 Helicobacter Infections Zinc 4.7217241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006527 Hepatolenticular Degeneration Zinc 4.9017276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4412621046 15340226 16120746
MESH:D006529 Hepatomegaly Trinitrotoluene 9.4415817613
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116959395 8697196 16354765 15340226 18606429
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.6717604070
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.2617937319
MESH:D007248 Infertility, Male Trinitrotoluene 7.2612150543
MESH:D007249 Inflammation Tamoxifen 5.1619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1612878042 12200463
MESH:D007511 Ischemia Zinc 4.8516584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Zinc 3.4116960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.5916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.2616705839
MESH:D007680 Kidney Neoplasms Tamoxifen 13.2618625569
MESH:D008064 Lipidoses Tamoxifen 3.2715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.777678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 18.7715890375 2125692 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.7721137059 20195826
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 18.7718177683
MESH:D008113 Liver Neoplasms Tamoxifen 18.7716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.7716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.406135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.408603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4012151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.7914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.7918816296 20869020 18569708 17053015 20464547 20064080 18520028 20135361 6695378
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 6.7919925653 18597497 19359593 15390079 11696405 11246140 16337739
MESH:D008175 Lung Neoplasms Tamoxifen 6.7918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.7911884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 10.821500032
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 10.8219196723 11731420 16827153 14580682 19196722
MESH:D008325 Mammary Neoplasms, Experimental Zinc 10.8212773700
MESH:D020149 Manganese Poisoning Tamoxifen 4.8119453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 19.2418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 19.2418551238 7678174
MESH:D009336 Necrosis Trinitrotoluene 19.2418551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2411141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.1616049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.1616049721
MESH:D009784 Occupational Diseases Trinitrotoluene 16.1612819281 14694615 17852074
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D011014 Pneumonia Butylated Hydroxytoluene 5.4011893704
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011225 Pre-Eclampsia Zinc 4.3117114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5717292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5715067354
MESH:D011471 Prostatic Neoplasms Zinc 2.5716517595 16606632 12429649 16700911
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration Zinc 4.2516584753
MESH:D012640 Seizures 2,4-dinitrotoluene 10.5918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.5918551238
MESH:D012640 Seizures Trinitrotoluene 10.5918551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4616709447
MESH:D013088 Spermatocele Tamoxifen 12.4616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2819457130
MESH:D013163 Splenomegaly Trinitrotoluene 5.4215817613
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D014062 Tongue Neoplasms Zinc 4.5616543248
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.4116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.4116049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.4117053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.4116712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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