AutismKB 2.0

Annotation Detail for AIM1


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Basic Information Top
Gene Symbol:AIM1 ( CRYBG1,ST4 )
Gene Full Name: absent in melanoma 1
Band: 6q21
Quick LinksEntrez ID:202; OMIM: 601797; Uniprot ID:AIM1_HUMAN; ENSEMBL ID: ENSG00000112297; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
Desease Name
NEUROLOGICAL
Stroke
Desease Name
Stroke
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of AIM1 mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of AIM1 mRNAaffects expression 17562736
C430898 AGN 194204 AGN 194204 results in decreased expression of AIM1 mRNAdecreases expression 16339527
D003907 Dexamethasone Dexamethasone results in increased expression of AIM1 mRNAincreases expression 12782123
C006253 pirinixic acid pirinixic acid results in increased expression of AIM1 mRNAincreases expression 18445702
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of AIM1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of AIM1 mRNAdecreases expression 19933214
18691609
D019772 Topotecan AIM1 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014635 Valproic Acid Valproic Acid results in increased expression of AIM1 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4614514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.468875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0516835633
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001169 Arthritis, Experimental Dexamethasone 3.6717659584
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618775368 18940202 18316065 19460635 18177632 18985861 17688650 18558336 16609825 15238991 17157402 19232924 20603192 18396377 17507914
MESH:D001714 Bipolar Disorder Valproic Acid 3.1817594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.5015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.508888407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.393084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915668235 15340226 12621046 8697196 16354765
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5215824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.9417728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9410048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.9417688650 16575769 8888407
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.7012438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003967 Diarrhea Dexamethasone 3.977237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5016109766 16393943 19739265 19420014 11287661 19923254 16081117 19164858 10915739 12392966 12705907 11834606 16177239 2444490 15968718 12958197 19085960 16485898 17906064 11421492 18071297 15619225 12153990 17562736 11743745 16227642 11739529 14986274 14725611 10663392 12540782 19370779 19416960 10774834 11461765 11529661 16781746 12594235 18713872 17522070 14550746
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.5019641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004485 Eczema Dexamethasone 4.7412438553
MESH:D004487 Edema Dexamethasone 12.8919703484
MESH:D004487 Edema pirinixic acid 12.8912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.8911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.463659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.293922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.806426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver pirinixic acid 8.5420131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 8.5414986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4118558336 8888407
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly pirinixic acid 9.3016221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3016120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.147520565
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4215340226 16959395 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Dexamethasone 5.5117042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5118850075 18670907
MESH:D007249 Inflammation Dexamethasone 5.4611099482 8960868
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4612878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1817596541 16294345
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 3.5816718785
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5812878042
MESH:D008107 Liver Diseases Acetaminophen 1.6719784758 12969438 19014921 16611625 19460945 12587719 11587558 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 4.5115890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008175 Lung Neoplasms Dexamethasone 2.5015824018 11195469
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5019555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008881 Migraine Disorders Valproic Acid 3.3618803445 18765137
MESH:D009101 Multiple Myeloma Dexamethasone 3.6716118317 15744524 15867202
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.989809623
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.9817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.2716359493 8888407
MESH:D009447 Neuroblastoma Topotecan 3.9615176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.6621297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6111399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.6120603192
MESH:D011471 Prostatic Neoplasms AGN 194204 4.2516000583
MESH:D019310 Pseudolymphoma Valproic Acid 4.9211422049 12752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.2818379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8911738929 11044598 16876388 3137016 15475178 14763951 17978042 1511512
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D013272 Stomach Diseases Dexamethasone 4.6615472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.7215138204
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Dexamethasone 5.191336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24649
    • No data
    Releated disease ID Related disease Name
    PA447054Stroke
    No data
    Drug Bank Top

    Simple Query:


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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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