AutismKB 2.0

Annotation Detail for ENDOG


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Basic Information Top
Gene Symbol:ENDOG ( FLJ27463 )
Gene Full Name: endonuclease G
Band: 9q34.11
Quick LinksEntrez ID:2021; OMIM: 600440; Uniprot ID:NUCG_HUMAN; ENSEMBL ID: ENSG00000167136; HGNC ID: 3346
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04210Apoptosis
No data
No data
Pathway IDPathway Name
P00006Apoptosis signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C046062 2-thiomalic acid [Hydrogen Peroxide co-treated with 2-thiomalic acid] affects the localization of ENDOG proteinaffects cotreatment|affects localization 16407272
D000640 Amitrole Amitrole results in decreased activity of ENDOG proteindecreases activity 16407272
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ENDOG mRNA]decreases expression|decreases reaction 11007951
D016572 Cyclosporine Cyclosporine results in decreased expression of ENDOG mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENDOG mRNAaffects cotreatment|increases expression 17942748
D006861 Hydrogen Peroxide [Hydrogen Peroxide co-treated with 2-thiomalic acid] affects the localization of ENDOG proteinaffects cotreatment|affects localization 16407272
D007529 Isoflavones Isoflavones results in decreased expression of ENDOG mRNAdecreases expression 17374662
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ENDOG mRNAaffects binding|decreases expression|increases activity 19710929
C059514 resveratrol resveratrol affects the localization of ENDOG proteinaffects localization 16617056
D012643 Selenium Selenium results in increased expression of ENDOG mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite results in decreased expression of ENDOG mRNAdecreases expression 12377979
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ENDOG mRNA]decreases expression|decreases reaction 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ENDOG mRNAdecreases expression 11007951
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENDOG mRNAaffects cotreatment|increases expression 17942748
D014810 Vitamin E Vitamin E results in increased expression of ENDOG mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9615322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D058186 Acute Kidney Injury resveratrol 3.9316538975
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma resveratrol 3.3615688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0416712894 17306315
MESH:D000505 Alopecia Isoflavones 4.7817569567
MESH:D000544 Alzheimer Disease resveratrol 2.5816162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.5215885639
MESH:D001169 Arthritis, Experimental resveratrol 7.5217115116
MESH:D050197 Atherosclerosis resveratrol 3.3217967414 16873680
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D002545 Brain Ischemia resveratrol 4.4017600658
MESH:D001943 Breast Neoplasms resveratrol 2.1316393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1320435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular resveratrol 3.2819321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.2815276417 17306315 16507464
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.7116675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.9216227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.9218572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 12.7116936243
MESH:D002318 Cardiovascular Diseases Isoflavones 12.7117689850
MESH:D002318 Cardiovascular Diseases resveratrol 12.7115458977
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8412371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.8420056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Cyclosporine 13.7019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.7016919318 17110522 16105132 15861022 17681005 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 13.7019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1312621046 15340226 16354765 15668235 8697196
MESH:D003092 Colitis resveratrol 10.0016474422
MESH:D003092 Colitis Selenium 10.0017936198
MESH:D003110 Colonic Neoplasms resveratrol 2.4716338953
MESH:D015179 Colorectal Neoplasms Isoflavones 3.0317116718
MESH:D015179 Colorectal Neoplasms resveratrol 3.0316550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.8016507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5015322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5019769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.8416873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies resveratrol 4.0316286809
MESH:D056486 Drug-Induced Liver Injury Selenium 3.8415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004487 Edema pirinixic acid 11.9112083418
MESH:D004487 Edema resveratrol 11.918985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.9112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.4417872969
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.9517923197
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 13.4819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.4815345470
MESH:D005234 Fatty Liver pirinixic acid 13.4820131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Cyclosporine 8.8312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8016452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7011294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7016080930
MESH:D006333 Heart Failure pirinixic acid 7.1120558911
MESH:D006333 Heart Failure Selenium 7.1117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.6119772884 19176532 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6112621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D006561 Herpes Simplex resveratrol 4.3016876885
MESH:D006689 Hodgkin Disease sodium arsenite 3.2212676792
MESH:D019584 Hot Flashes Isoflavones 10.9617290160 14716179
MESH:D019584 Hot Flashes Vitamin E 10.9614716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 18606429 8697196 16959395 16354765
MESH:D006937 Hypercholesterolemia resveratrol 4.0917188708
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006949 Hyperlipidemias resveratrol 4.1116873680
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.3817488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.7517600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8217937319
MESH:D007248 Infertility, Male sodium arsenite 6.8215346721 12646999
MESH:D007249 Inflammation resveratrol 5.2016366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2012878042 12200463
MESH:D007251 Influenza, Human resveratrol 19.4516624496
MESH:D007251 Influenza, Human Selenium 19.4516624496
MESH:D007251 Influenza, Human Vitamin E 19.4516624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Cyclosporine 10.358314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 10.3520008137
MESH:D007674 Kidney Diseases Vitamin E 10.3512488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 10.3016518626
MESH:D007676 Kidney Failure, Chronic Selenium 10.3016518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8012371664
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6316087638
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4512878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4516169303
MESH:D008113 Liver Neoplasms pirinixic acid 10.9420007298 16377806 15890375
MESH:D008113 Liver Neoplasms resveratrol 10.9420405173 19321006 19812893 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 10.9416712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1512151625
MESH:D008171 Lung Diseases sodium arsenite 7.6219095001
MESH:D008171 Lung Diseases Vitamin E 7.6216863852
MESH:D008175 Lung Neoplasms sodium arsenite 3.4515276417 16712894 19931552 17306315 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4511884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.4511062179
MESH:D016393 Lymphoma, B-Cell resveratrol 4.3917088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.9414749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.3615688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.3911606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.3915318939
MESH:D008545 Melanoma resveratrol 3.5417992120
MESH:D008545 Melanoma sodium arsenite 3.5416487513 19082730
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D008659 Metabolic Diseases resveratrol 4.4617112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009101 Multiple Myeloma resveratrol 3.5216267019 16490592 14749477 17049120 17935668 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.9917962980
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.8419151258
MESH:D009203 Myocardial Infarction resveratrol 5.8417188708 16456233 16525036 17015251 16317513 17125593
MESH:D017202 Myocardial Ischemia resveratrol 9.2317015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.2312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009205 Myocarditis resveratrol 4.8817322642
MESH:D009369 Neoplasms pirinixic acid 5.0717405874
MESH:D009369 Neoplasms sodium arsenite 5.0711559025
MESH:D009374 Neoplasms, Experimental resveratrol 9.588985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 9.5820056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1912854658
MESH:D019636 Neurodegenerative Diseases resveratrol 3.8717652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.4917929310
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D010024 Osteoporosis Isoflavones 4.1516562857
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.3417513867
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4615276417 17306315
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010212 Papilloma Hydrogen Peroxide 4.1912065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.9916679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.9911896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Isoflavones 2.1417571952 17374662 17219775 16365062
MESH:D011471 Prostatic Neoplasms resveratrol 2.1416731767 17718901 17804756 15767336 17675339 17636462
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1416039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1415084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.7216325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.7019058328
MESH:D015427 Reperfusion Injury resveratrol 6.7016314181 17058453 17520802 16317513 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 13.9012065085
MESH:D012878 Skin Neoplasms resveratrol 13.908985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 13.9018572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.9016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8612854658
MESH:D020521 Stroke Vitamin E 3.5816517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.5616321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D014062 Tongue Neoplasms resveratrol 4.2916227395
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5316712894 16452187 17306315 11723127
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.8217473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.8211813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.8214692618
MESH:D014594 Uterine Neoplasms resveratrol 9.8217044934
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D014652 Vascular Diseases sodium arsenite 4.5417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.4117488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
KEGG:04210 Apoptosis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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