AutismKB 2.0

Annotation Detail for ENO1


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Basic Information Top
Gene Symbol:ENO1 ( ENO1L1,MPB1,NNE,PPH )
Gene Full Name: enolase 1, (alpha)
Band: 1p36.23
Quick LinksEntrez ID:2023; OMIM: 172430; Uniprot ID:ENOA_HUMAN; ENSEMBL ID: ENSG00000074800; HGNC ID: 3350
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
ANARESP1-PWYrespiration (anaerobic)
GLYCOLYSISglycolysis I
PWY-5484glycolysis II
GLUCONEO-PWYgluconeogenesis I
ANAGLYCOLYSIS-PWYglycolysis III
Pathway IDPathway Name
hsa00010Glycolysis / Gluconeogenesis
hsa03018RNA degradation
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of carbohydrates
Pathway IDPathway Name
200013Notch signaling pathway
200172HIF-1-alpha transcription factor network
200045Validated targets of C-MYC transcriptional activation
Pathway IDPathway Name
P00024Glycolysis
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1781Rheumatoid arthritis
1831Prostate cancer
1869Behcet syndrome
2126Encephalopathies
No data
No data
Desease Name
Enolase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016614 1-nitronaphthalene 1-nitronaphthalene metabolite binds to ENO1 proteinaffects binding 16453347
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ENO1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ENO1 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of ENO1 mRNAdecreases expression 12958071
C016601 4-hydroxytamoxifen ENO1 mRNA results in decreased susceptibility to 4-hydroxytamoxifendecreases response to substance 19655245
D000082 Acetaminophen Acetaminophen results in increased expression of ENO1 mRNAincreases expression 15800402
D000082 Acetaminophen Acetaminophen results in increased expression of ENO1 proteinincreases expression 15800402
16538041
C061621 alpha-naphthyl isocyanate alpha-naphthyl isocyanate affects the expression of ENO1 proteinaffects expression 16099942
D000638 Amiodarone Amiodarone affects the expression of ENO1 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ENO1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of ENO1 mRNAdecreases expression 18315880
D001553 Benzbromarone Benzbromarone affects the expression of ENO1 mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ENO1 proteinincreases expression 17292933
C095105 bexarotene bexarotene results in increased expression of ENO1 mRNAincreases expression 16648578
C110172 BHTOH-QM BHTOH-QM binds to ENO1 proteinaffects binding 16533022
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in increased expression of ENO1 mRNAincreases expression 15912405
C006780 bisphenol A bisphenol A results in increased expression of ENO1 mRNAincreases expression 12075121
C099555 CD 437 CD 437 results in decreased expression of ENO1 mRNAdecreases expression 12958071
D002994 Clofibrate Clofibrate affects the expression of ENO1 mRNAaffects expression 19483382
D003024 Clozapine Clozapine results in increased expression of ENO1 mRNAincreases expression 15860345
D003474 Curcumin Curcumin results in decreased expression of ENO1 mRNAdecreases expression 16880289
C014347 decitabine decitabine results in increased expression of ENO1 mRNAincreases expression 17908484
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of ENO1 mRNAdecreases expression 17490981
D004052 Diethylnitrosamine [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of ENO1 mRNAaffects cotreatment|increases expression 16158176
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ENO1 mRNAaffects cotreatment|increases expression 14656948
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of ENO1 mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in increased expression of ENO1 mRNAincreases expression 15289156
D000431 Ethanol Ethanol results in increased expression of ENO1 mRNAincreases expression 15353170
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ENO1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ENO1 mRNAincreases expression 12075121
17557909
D005001 Ethionine Ethionine affects the expression of ENO1 mRNAaffects expression 19483382
D015073 2-Acetylaminofluorene [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of ENO1 mRNAaffects cotreatment|increases expression 16158176
D015073 2-Acetylaminofluorene [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ENO1 mRNAaffects cotreatment|increases expression 14656948
C039281 furan furan results in increased expression of ENO1 mRNAincreases expression 15120968
D019833 Genistein Genistein results in increased expression of ENO1 mRNAincreases expression 15289156
D019833 Genistein Genistein results in increased expression of ENO1 mRNAincreases expression 12075121
C511402 Grape Seed Proanthocyanidins Grape Seed Proanthocyanidins affects the expression of ENO1 proteinaffects expression 16414080
D006220 Haloperidol Haloperidol results in increased expression of ENO1 mRNAincreases expression 15860345
D007052 Ibuprofen Ibuprofen affects the expression of ENO1 proteinaffects expression 18351690
C051890 irinotecan irinotecan analog results in decreased expression of ENO1 mRNAdecreases expression 18927307
D008344 Maneb [Paraquat co-treated with Maneb] results in decreased expression of ENO1 mRNAaffects cotreatment|decreases expression 17532186
D008344 Maneb [Paraquat co-treated with Maneb] results in decreased expression of ENO1 proteinaffects cotreatment|decreases expression 17532186
C031721 naphthalene naphthalene metabolite binds to ENO1 proteinaffects binding 16453347
C029938 nickel sulfate nickel sulfate results in increased expression of ENO1 mRNAincreases expression 16100012
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of ENO1 mRNAincreases expression 17616710
C510003 nordy nordy results in increased expression of ENO1 proteinincreases expression 18232056
D009853 Omeprazole Omeprazole affects the expression of ENO1 mRNAaffects expression 19483382
D010269 Paraquat [Paraquat co-treated with Maneb] results in decreased expression of ENO1 mRNAaffects cotreatment|decreases expression 17532186
D010269 Paraquat [Paraquat co-treated with Maneb] results in decreased expression of ENO1 proteinaffects cotreatment|decreases expression 17532186
C006253 pirinixic acid pirinixic acid affects the expression of ENO1 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of ENO1 mRNAaffects expression 19483382
D011794 Quercetin Quercetin results in increased expression of ENO1 proteinincreases expression 17292933
C009159 rapeseed oil rapeseed oil affects the expression of ENO1 mRNAaffects expression 16177195
C059514 resveratrol resveratrol results in decreased expression of ENO1 mRNAdecreases expression 15582268
C017947 sodium arsenite sodium arsenite results in increased expression of ENO1 mRNAincreases expression 17450228
D014284 Triiodothyronine Triiodothyronine results in increased expression of ENO1 mRNAincreases expression 15507505
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ENO1 proteindecreases expression 16548065
D013853 Thioacetamide Thioacetamide affects the expression of ENO1 mRNAaffects expression 19483382
D014212 Tretinoin Tretinoin affects the expression of ENO1 mRNAaffects expression 16054129
D014212 Tretinoin Tretinoin results in decreased expression of ENO1 proteindecreases expression 17051635
D014810 Vitamin E Vitamin E results in increased expression of ENO1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 11.3117676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Maneb 11.31982313
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.3115322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 8.6218287403
MESH:D000138 Acidosis Ethanol 8.6211192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3817505938
MESH:D058186 Acute Kidney Injury Ibuprofen 7.426375363
MESH:D058186 Acute Kidney Injury resveratrol 7.4216538975
MESH:D055371 Acute Lung Injury 1-nitronaphthalene 12.5515204773
MESH:D055371 Acute Lung Injury nickel sulfate 12.5511954676 16100012 19131640 12718980
MESH:D055371 Acute Lung Injury pirinixic acid 12.5518653653
MESH:D000230 Adenocarcinoma marker/mechanism 15378696
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 11.6520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 11.6511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 11.6514692618
MESH:D000230 Adenocarcinoma Genistein 11.6511473722
MESH:D000230 Adenocarcinoma Ibuprofen 11.6510697514
MESH:D000236 Adenoma 2-Acetylaminofluorene 13.1810737359
MESH:D000236 Adenoma Benzo(a)pyrene 13.186695378
MESH:D000236 Adenoma Diethylnitrosamine 13.186695378 10737359
MESH:D000236 Adenoma resveratrol 13.1815688382
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.446705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.0617620307 18056438 19061943 17162532 19052882 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.0616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.0616835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1315276417
MESH:D018246 Adrenocortical Adenoma Arsenic 11.9017306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 11.9016712894 17306315
MESH:D000380 Agranulocytosis Clozapine 4.5112649775 16160616 14617031
MESH:D000382 Agricultural Workers' Diseases Maneb 7.488807224
MESH:D000382 Agricultural Workers' Diseases Paraquat 7.4811874814
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.7515451040 15451039
MESH:D019973 Alcohol-Related Disorders Curcumin 4.5117887948
MESH:D000505 Alopecia Tretinoin 3.1715955085
MESH:D000544 Alzheimer Disease Curcumin 5.8715590663
MESH:D000544 Alzheimer Disease Ibuprofen 5.8718351690
MESH:D000544 Alzheimer Disease resveratrol 5.8716162502 16183991
MESH:D000686 Amyloidosis Diethylstilbestrol 3.9515469931
MESH:D000707 Anaphylaxis Ibuprofen 4.709532969
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4611748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.7417084956
MESH:D000799 Angioedema Acetaminophen 3.2810982225
MESH:D000853 Anophthalmos Ethanol 4.2815513904
MESH:D001008 Anxiety Disorders Ethanol 3.5611141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5319183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.3220041841 18218290 18057881
MESH:D020261 Arsenic Poisoning Arsenic 2.6912569548 16835338 16251483 18414634
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.1615885639
MESH:D001169 Arthritis, Experimental resveratrol 10.1617115116
MESH:D001169 Arthritis, Experimental Tretinoin 10.1616412693
MESH:D001172 Arthritis, Rheumatoid marker/mechanism 19898480
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.1816807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.1816292516
MESH:D001249 Asthma Tretinoin 2.1616456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4215336622
MESH:D050197 Atherosclerosis Arsenic 9.0612928151 19371607
MESH:D050197 Atherosclerosis Curcumin 9.0618704882
MESH:D050197 Atherosclerosis resveratrol 9.0616873680 17967414
MESH:D001281 Atrial Fibrillation Amiodarone 3.4819698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 2.1318445737
MESH:D001321 Autistic Disorder Haloperidol 2.1318080171 19368416
MESH:D001327 Autoimmune Diseases Curcumin 9.0619761891
MESH:D001327 Autoimmune Diseases Quercetin 9.0619761891
MESH:D001471 Barrett Esophagus Tretinoin 3.8716935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 55.1419483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 55.1419483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 55.1419483382
MESH:D001778 Blood Coagulation Disorders Ethionine 55.1419483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 55.1419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 55.1419483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 55.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 55.1412125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 55.1419483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 55.1416197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3915746008
MESH:D001862 Bone Resorption bisphenol A 3.3711985600
MESH:D002545 Brain Ischemia Curcumin 13.9616770732
MESH:D002545 Brain Ischemia Ibuprofen 13.9615837124
MESH:D002545 Brain Ischemia resveratrol 13.9617600658
MESH:D001932 Brain Neoplasms Curcumin 3.4617596214
MESH:D001943 Breast Neoplasms marker/mechanism 19655245
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 11.4217474063 20146248
MESH:D001943 Breast Neoplasms bexarotene 11.4216818667 16344269
MESH:D001943 Breast Neoplasms bisphenol A 11.4217123778
MESH:D001943 Breast Neoplasms Curcumin 11.4218462866 19250217 16243823 18593918
MESH:D001943 Breast Neoplasms decitabine 11.4219208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 11.4217474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 11.4217129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 11.4212948864 16675129 14630087 17261762 17018787 19861407 17289903 18497071
MESH:D001943 Breast Neoplasms Genistein 11.4217200150 16873071 16541309
MESH:D001943 Breast Neoplasms Grape Seed Proanthocyanidins 11.4220146248
MESH:D001943 Breast Neoplasms Quercetin 11.4218628248
MESH:D001943 Breast Neoplasms resveratrol 11.4216393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.4220435547
MESH:D001943 Breast Neoplasms Tretinoin 11.4216873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0316813970
MESH:D002056 Burns Ethanol 4.1116374292
MESH:D002100 Cachexia Ibuprofen 4.9115141370
MESH:D002105 Cadmium Poisoning Quercetin 4.9816962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9116111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.3916050911
MESH:D002277 Carcinoma Curcumin 6.8118593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.8116835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.2615504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 39.2216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 39.2216705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 39.2217761372 6705139 3084413 3581430 10737359
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 39.223084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 39.2217306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 39.221701930
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 39.2219208518 16779866 18788625 20512989 19701751 18785209 20214788 11831363 18210153 20101231 16878318 18056438 16569478 19394651 19052882 3581430 16935385 21159647 18506893 18971187 3084413 19519916 17055752 19107877 17138121 20432363 19171122 20084675 10672840 18691550 17978847 17761372 19539802 17162532 17173139 19383236 16288022 16681979 19919837 20935162 16502159 18494052 18978308 20007298 20727157 18665156 16328049 19418558 16540662 17428255 16830150 19822196 20514400 18393292 16698587 10737359 16807293 19335982 20524982
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 39.2216924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 39.2216924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 39.2215289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 39.2216924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 39.2219519916 12508355
MESH:D006528 Carcinoma, Hepatocellular resveratrol 39.2219321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 39.2215276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 39.2217997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 39.221917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.4317123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.0416675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.0916247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.0918414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4117234771
MESH:D002294 Carcinoma, Squamous Cell Arsenic 18.9417687452 15504454 18922899
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 18.9420419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 18.9418462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 18.9419215824
MESH:D002294 Carcinoma, Squamous Cell resveratrol 18.9416227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 18.9418572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 18.9416096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.5918640142
MESH:D006332 Cardiomegaly Ethanol 9.5319332462
MESH:D006332 Cardiomegaly Quercetin 9.5319794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 9.5318670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.6819225199 15710769
MESH:D002318 Cardiovascular Diseases Arsenic 9.9517938729 19152805 15738583
MESH:D002318 Cardiovascular Diseases Genistein 9.9516332659
MESH:D002318 Cardiovascular Diseases resveratrol 9.9515458977
MESH:D002340 Carotid Artery Diseases Arsenic 3.8418022660 16973168
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.5318974383
MESH:D002375 Catalepsy Haloperidol 4.3615215559 1977408
MESH:D002386 Cataract Acetaminophen 6.0610977129
MESH:D002386 Cataract Tretinoin 6.0617460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.916135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 16.911399818
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.912727394 17174075 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.9118566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 16.9119524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0316129372
MESH:D002637 Chest Pain Omeprazole 4.5415447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 13.3919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 13.3916835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 13.3918291259
MESH:D002779 Cholestasis Ethinyl Estradiol 6.3417681005 16105132 17333356 16919318 15861022 11677210 17110522
MESH:D002779 Cholestasis pirinixic acid 6.3419176532
MESH:D002822 Choriocarcinoma Tretinoin 4.5916461808
MESH:D002971 Cleft Lip Ethanol 3.2715513904
MESH:D002972 Cleft Palate Ethanol 8.3015513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.3016354765 8697196 12621046 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 8.309407595
MESH:D003072 Cognition Disorders Clozapine 4.4217123785
MESH:D003092 Colitis Curcumin 12.9616804969 16782535 18200517
MESH:D003092 Colitis resveratrol 12.9616474422
MESH:D003092 Colitis Tretinoin 12.9617035595
MESH:D003103 Coloboma Curcumin 4.0518809619
MESH:D003110 Colonic Neoplasms Curcumin 12.2919359593 16340194
MESH:D003110 Colonic Neoplasms decitabine 12.2917616700
MESH:D003110 Colonic Neoplasms Genistein 12.2917182828
MESH:D003110 Colonic Neoplasms irinotecan 12.2917287894 17725105
MESH:D003110 Colonic Neoplasms Quercetin 12.2917148506 19056647 19440933 16640504 11134977 15741050 17191121
MESH:D003110 Colonic Neoplasms resveratrol 12.2916338953
MESH:D015179 Colorectal Neoplasms decitabine 4.2618981723
MESH:D015179 Colorectal Neoplasms irinotecan 4.2616391804 18509181 18259882 17454858 15273666 17159606 16303861
MESH:D015179 Colorectal Neoplasms Quercetin 4.2618095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 4.2616550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5914669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.3518497527
MESH:D003327 Coronary Disease resveratrol 3.3816507316
MESH:D019465 Craniofacial Abnormalities Ethanol 4.7415451039 11873399 19302082 15513904 11198716 15451040 10194807
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.7415322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.749664655 17551590 8800419 10589399 9125849 16925845 9211117 9224671 9142499 14991402
MESH:D019465 Craniofacial Abnormalities Vitamin E 4.7419769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.0316002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.0918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.0918551238
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.3320210726
MESH:D003704 Dementia Haloperidol 4.0811575062
MESH:D017449 Dermatitis, Allergic Contact Maneb 6.138807224
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 6.1311298694 16780908 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1418249437
MESH:D009783 Dermatitis, Occupational Maneb 5.318807224
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.0419496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 7.0416873680
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 11.7816402076
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 11.7818403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 11.7820387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 11.7816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 11.7817107852
MESH:D003928 Diabetic Nephropathies Curcumin 12.3718204486
MESH:D003928 Diabetic Nephropathies Estradiol 12.3719279558
MESH:D003928 Diabetic Nephropathies resveratrol 12.3716286809
MESH:D006970 Disorders of Excessive Somnolence Clozapine 4.9915331141
MESH:D056486 Drug-Induced Liver Injury marker/mechanism 16099942
MESH:D056486 Drug-Induced Liver Injury 1-nitronaphthalene 21.878212003
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 21.8721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 21.8718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 21.8712540782 10915739 11529661 14986274 14550746 12392966 17906064 11421492 11743745 16227642 11739529 18071297 2444490 17562736 19923254 19370779 10774834 17522070 12153990 16081117 15619225 16781746 12594235 15968718 18713872 11287661 19164858 16109766 10663392 19416960 19420014 11834606 12705907 11461765 19085960 16485898 16177239 19739265 16393943 12958197 14725611
MESH:D056486 Drug-Induced Liver Injury Amiodarone 21.8715265979 18218290
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 21.8719107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 21.8711566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 21.8720420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 21.8712963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3411462148
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.0618446180 16133044 18450898
MESH:D004381 Duodenal Ulcer Curcumin 7.7417351913
MESH:D004381 Duodenal Ulcer Omeprazole 7.7417151854 16613094 15991576 21218061
MESH:D050171 Dyslipidemias Clofibrate 7.7216707586
MESH:D050171 Dyslipidemias Clozapine 7.7216402076
MESH:C538011 Eales disease Vitamin E 4.149068938
MESH:D004487 Edema pirinixic acid 8.5912083418
MESH:D004487 Edema resveratrol 8.598985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.5911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.0618230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.0618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.3812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 7.3817872969
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.5519294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.0416402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.0416402032
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 19.3419148513
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 19.3416804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 19.3419148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 19.3411473722
MESH:D016889 Endometrial Neoplasms Tretinoin 19.3416569247
MESH:D004715 Endometriosis Ibuprofen 7.6315652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.639294722 10568697
MESH:D019446 Endotoxemia Ibuprofen 4.4111545620
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.3017923197
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5516302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.3216530937
MESH:D004938 Esophageal Neoplasms Ethanol 6.3216704527
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 6.3215264214 16805852 15547733 15878914 16510608 15150132 15623463 16704527 15547721
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.4311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.439664655 16938888
MESH:D005218 Fat Necrosis Thioacetamide 5.1516456712
MESH:D005234 Fatty Liver Amiodarone 29.3614986274
MESH:D005234 Fatty Liver Clofibrate 29.3619224547
MESH:D005234 Fatty Liver Curcumin 29.3619297423
MESH:D005234 Fatty Liver Diethylnitrosamine 29.3620387270 21071580
MESH:D005234 Fatty Liver Ethanol 29.3619236843 18620774 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.3615345470
MESH:D005234 Fatty Liver pirinixic acid 29.3619236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1017920746
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.3016534752 16513791 15751030 16611131 16002989
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.7415513904 10194807 15451040 16946407
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9111858732
MESH:D005334 Fever Ibuprofen 4.1016997862
MESH:D005355 Fibrosis Curcumin 16.7618705752
MESH:D005355 Fibrosis Quercetin 16.7619474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.7620067830
MESH:D005355 Fibrosis Tretinoin 16.7617994277
MESH:D005534 Foot Diseases Arsenic 4.996392382
MESH:D005756 Gastritis Acetaminophen 9.2416983495
MESH:D005756 Gastritis Ethanol 9.2415046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.1518462866
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 10.9616452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 10.9616452187
MESH:D005909 Glioblastoma Curcumin 13.8617596214
MESH:D005909 Glioblastoma Genistein 13.8616598420
MESH:D005909 Glioblastoma Quercetin 13.8619804834
MESH:D005909 Glioblastoma Tretinoin 13.8617312396
MESH:D005910 Glioma Quercetin 2.8117643826
MESH:D005911 Gliosis Maneb 12.5411124998
MESH:D005911 Gliosis Paraquat 12.5411124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0310696789
MESH:D006258 Head and Neck Neoplasms Curcumin 10.7518829502 18462866
MESH:D006258 Head and Neck Neoplasms decitabine 10.7519215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 10.7516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 13.3320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 13.3310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 13.339664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 13.3316080930
MESH:D006331 Heart Diseases Grape Seed Proanthocyanidins 4.6312587719
MESH:D006333 Heart Failure pirinixic acid 2.1820558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 4.756705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 3.916705139
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8411000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.0718665440 17276928 15929193
MESH:D006505 Hepatitis Thioacetamide 3.6916456712
MESH:D006529 Hepatomegaly Amiodarone 11.2915265979
MESH:D006529 Hepatomegaly pirinixic acid 11.2919176532 19772884 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.2912621046 16120746 15340226
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.5017701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.4816863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.4615709030
MESH:D006561 Herpes Simplex resveratrol 3.6316876885
MESH:D006689 Hodgkin Disease sodium arsenite 2.7012676792
MESH:D019584 Hot Flashes Estradiol 8.1717088409
MESH:D019584 Hot Flashes Vitamin E 8.1714716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4816959395 8697196 16354765 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 10.5016870215
MESH:D006930 Hyperalgesia Ethanol 10.5018783367
MESH:D006930 Hyperalgesia Tretinoin 10.5016870215
MESH:D006937 Hypercholesterolemia Amiodarone 12.538137927 9751232
MESH:D006937 Hypercholesterolemia Curcumin 12.5318704882
MESH:D006937 Hypercholesterolemia resveratrol 12.5317188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0216778211
MESH:D006943 Hyperglycemia pirinixic acid 7.6320558911
MESH:D006943 Hyperglycemia Quercetin 7.6311834736 18262572
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 3.9717050553
MESH:D006948 Hyperkinesis Clozapine 4.3516046005
MESH:D006949 Hyperlipidemias resveratrol 3.5216873680
MESH:D006965 Hyperplasia Diethylstilbestrol 3.8914722030 12960047
MESH:D006973 Hypertension Arsenic 7.2511953799 16076760 9931084
MESH:D006973 Hypertension Quercetin 7.2518356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.2518850075 18670907
MESH:D006984 Hypertrophy Ibuprofen 4.4816672835
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8217488730
MESH:D006987 Hypesthesia Arsenic 4.9916093927
MESH:D007021 Hypospadias Diethylstilbestrol 9.4416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.4416569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 9.8117991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 9.8118031379 8137927
MESH:D007235 Infant, Premature, Diseases Ibuprofen 5.2716133044
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.1017600658
MESH:D007246 Infertility Diethylstilbestrol 3.8315036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9512013081
MESH:D007248 Infertility, Male decitabine 12.8817581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 12.8817937319
MESH:D007248 Infertility, Male Paraquat 12.884850670
MESH:D007248 Infertility, Male sodium arsenite 12.8812646999 15346721
MESH:D007249 Inflammation Curcumin 12.5217151092 18403477 16956363
MESH:D007249 Inflammation Diethylnitrosamine 12.5218785209
MESH:D007249 Inflammation Ibuprofen 12.523291741
MESH:D007249 Inflammation resveratrol 12.5216366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.5212878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9618596194 18200517
MESH:D007251 Influenza, Human Quercetin 15.3916624496
MESH:D007251 Influenza, Human resveratrol 15.3916624496
MESH:D007251 Influenza, Human Vitamin E 15.3916624496
MESH:D007333 Insulin Resistance bisphenol A 10.1116393666
MESH:D007333 Insulin Resistance Estradiol 10.1116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 10.1116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.2317994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.7310783313
MESH:D007569 Jaw Abnormalities Ethanol 14.2915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 14.2916580747
MESH:D007569 Jaw Abnormalities Tretinoin 14.2915992940 17551590
MESH:D007627 Keloid Quercetin 4.4117086741
MESH:D007642 Keratosis Arsenic 4.4316930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 19.4212587719 15629191
MESH:D007674 Kidney Diseases Estradiol 19.4215618244
MESH:D007674 Kidney Diseases Grape Seed Proanthocyanidins 19.4212587719
MESH:D007674 Kidney Diseases Quercetin 19.4216962696
MESH:D007674 Kidney Diseases sodium arsenite 19.4220008137
MESH:D007674 Kidney Diseases Vitamin E 19.4212488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.0416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.0416705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 14.0414681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 14.0415610895
MESH:D007859 Learning Disorders Diethylstilbestrol 7.9917184923
MESH:D007859 Learning Disorders Ethanol 7.9915451040
MESH:D007889 Leiomyoma Curcumin 4.0618555241
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.6419248655
MESH:D007938 Leukemia Curcumin 16.4618462866
MESH:D007938 Leukemia decitabine 16.4619235587 18980019
MESH:D007938 Leukemia Genistein 16.4618980019 17468513
MESH:D007938 Leukemia Quercetin 16.4617468513
MESH:D007938 Leukemia Tretinoin 16.4617143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.7116106398
MESH:D007951 Leukemia, Myeloid decitabine 7.9119117987 17236224 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 7.9116932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.5418460780 18704418 19010910 19387464 17679729 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.5419850784 17596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.8918055864
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 10.6217339181
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 10.6216087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 10.6217368321 12679006 17217047 19029980 16935935 17506722 17301526 19075265 16331271 19225113 15748426 19642359 16766008 17339181 16140955 17294898 16788101 16891316 9834237 19035177 17649720 17107899 16823087 17361223 17712046
MESH:D015458 Leukemia, T-Cell Curcumin 4.2316106398
MESH:D017880 Limb Deformities, Congenital Ethanol 6.9517676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 6.959224671
MESH:D008064 Lipidoses Amiodarone 6.8517567588 15342952
MESH:D008064 Lipidoses Clozapine 6.8517567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.7118407596 18665156 20032147 19638242 18522880
MESH:D008103 Liver Cirrhosis Ethanol 5.7115289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.5418295389
MESH:D008106 Liver Cirrhosis, Experimental alpha-naphthyl isocyanate 18.5916015684
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 18.5918006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 18.5914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 18.5918166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 18.5917823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 18.5915474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 18.5912741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 18.5912878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 18.5916511523 15095483 18416461 16126171 11172339 17292413 18606216 17629604 15078482 16248980 12557150 18032466 16489207 18295389 15075984 18031379 17127702 15316131 15334695 15474484 12175628 11682029 15362042 15716488 18395095 18458672 14739098 18380797 16098781 17355460 12531686 15465738 12085344 15158331 18615449 16343077 15288473 15288472 17050028 12891558 18263696 16097051 12679928 11481614 10677585
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 18.5916248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 18.5916169303
MESH:D008107 Liver Diseases Acetaminophen 13.5212969438 12587719 19460945 16611625 19014921 11587558 19784758 16610002
MESH:D008107 Liver Diseases Arsenic 13.5211134558
MESH:D008107 Liver Diseases Curcumin 13.5216956363
MESH:D008107 Liver Diseases Diethylnitrosamine 13.5217034775
MESH:D008107 Liver Diseases Grape Seed Proanthocyanidins 13.5212587719
MESH:D008107 Liver Diseases Thioacetamide 13.5218374380 16337175 15158337
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1117207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 8.0217185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 8.0212479984 15633222 17276928 15313186
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 32.877678174
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 32.8718001218 10737359 10672840 14678523 16273603 11376686
MESH:D008113 Liver Neoplasms Arsenic 32.8716368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 32.8721137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 32.8719427195 19996281 20501860 19255062 19833225 20583210 9163691 19294768 20492335 19254457 20405173 19499222 10737359 19638242 15885732 15175105 19073162 18754104 20118626 19426721 21047994 21278145 19256749 18644402 2862719 18648771 21071580 19690152 2422723 12112319 20452335 20101389 19642983 18977376 19850985 20137499 20434301 12771043 16942905 21167192 19551842 18978307 19090486 19812893
MESH:D008113 Liver Neoplasms Diethylstilbestrol 32.8716712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 32.8715890375 20007298 16377806
MESH:D008113 Liver Neoplasms Quercetin 32.8718980244
MESH:D008113 Liver Neoplasms resveratrol 32.8719073162 19812893 20405173 19321006
MESH:D008113 Liver Neoplasms sodium arsenite 32.8716712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 32.8716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.782876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 14.78534488 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.7818775883 18282651 19539802 19519916 19009564 9362446 16267830 18544905 18253720 21159647 17174075 19126423 17854601 2563599 18164116 16842330 17942915 18308698 3124819 19004024 18079962 18093689
MESH:D008114 Liver Neoplasms, Experimental Quercetin 14.7819519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.7812151625
MESH:D008133 Long QT Syndrome Amiodarone 3.1511989578 15350150 17391786
MESH:D008171 Lung Diseases 1-nitronaphthalene 19.028212003
MESH:D008171 Lung Diseases Amiodarone 19.0212587719
MESH:D008171 Lung Diseases Grape Seed Proanthocyanidins 19.0212587719
MESH:D008171 Lung Diseases sodium arsenite 19.0219095001
MESH:D008171 Lung Diseases Vitamin E 19.0216863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.9118516814
MESH:D055370 Lung Injury 1-nitronaphthalene 8.402384072
MESH:D055370 Lung Injury naphthalene 8.406834280
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 15.8411376686
MESH:D008175 Lung Neoplasms Arsenic 15.8419168569 17306315 17976673
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 15.8418569708 20064080 20464547 17053015 18816296 20135361 18520028 6695378 20869020
MESH:D008175 Lung Neoplasms bexarotene 15.8417849452
MESH:D008175 Lung Neoplasms Curcumin 15.8419359593 16243823 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 15.846695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Quercetin 15.8416280456
MESH:D008175 Lung Neoplasms sodium arsenite 15.8416712894 15276417 17306315 17077188 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 15.8419555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 15.8411062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.5915166399
MESH:D008223 Lymphoma Curcumin 10.2818462866
MESH:D008223 Lymphoma decitabine 10.2819470736
MESH:D008223 Lymphoma Diethylstilbestrol 10.2815700306
MESH:D016393 Lymphoma, B-Cell resveratrol 3.7917088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.4114749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.1516173963
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.6011161223
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.9516002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.6915688416
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 14.8819196723 15591091 19196722
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 14.8816891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 14.8814578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 14.8810697514
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 14.888985016 11606380
MESH:D020149 Manganese Poisoning Estradiol 3.9219453300
MESH:D008527 Medulloblastoma Tretinoin 2.5417453147
MESH:D008545 Melanoma Curcumin 8.4018462866 17885582
MESH:D008545 Melanoma decitabine 8.4017785578 16505122
MESH:D008545 Melanoma resveratrol 8.4017992120
MESH:D008545 Melanoma sodium arsenite 8.4016487513 19082730
MESH:D008545 Melanoma Tretinoin 8.4016752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0219513568
MESH:D008569 Memory Disorders Curcumin 8.0017263510
MESH:D008569 Memory Disorders Ethanol 8.0018411066 15451040
MESH:D008591 Meningomyelocele Tretinoin 3.8816940565
MESH:D001523 Mental Disorders Clozapine 6.5516856516
MESH:D001523 Mental Disorders Haloperidol 6.5516856516
MESH:D008659 Metabolic Diseases resveratrol 3.8817112576
MESH:D024821 Metabolic Syndrome X Clozapine 3.9519142101
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.7616381670
MESH:D052016 Mucositis irinotecan 4.4517159606
MESH:D009101 Multiple Myeloma Curcumin 9.8719372569
MESH:D009101 Multiple Myeloma decitabine 9.8718172295
MESH:D009101 Multiple Myeloma resveratrol 9.8714749477 16490592 16267019 17935668 17164350 17049120
MESH:D009134 Muscular Atrophy, Spinal Curcumin 10.5617962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 10.5617962980
MESH:D009135 Muscular Diseases pirinixic acid 2.9716239165
MESH:D009181 Mycoses Amiodarone 4.3317974566 12754197
MESH:D009190 Myelodysplastic Syndromes decitabine 6.3419010910 16882708 19157545 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.3417596541
MESH:D009203 Myocardial Infarction Genistein 11.3917141266
MESH:D009203 Myocardial Infarction pirinixic acid 11.3919151258
MESH:D009203 Myocardial Infarction Quercetin 11.3919595682
MESH:D009203 Myocardial Infarction resveratrol 11.3916456233 17188708 17125593 16317513 16525036 17015251
MESH:D017202 Myocardial Ischemia Arsenic 12.7215371236
MESH:D017202 Myocardial Ischemia resveratrol 12.7217015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 12.7212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 16.7416810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 16.7417141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 16.7416411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 16.7419207477
MESH:D009205 Myocarditis resveratrol 4.2017322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.5018551238 7678174
MESH:D009361 Neoplasm Invasiveness Curcumin 3.8418495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.119029167 3581430
MESH:D009362 Neoplasm Metastasis irinotecan 5.1118259882
MESH:D009369 Neoplasms Benzo(a)pyrene 19.3711141357
MESH:D009369 Neoplasms decitabine 19.3717925555 19116145 19470736
MESH:D009369 Neoplasms Diethylstilbestrol 19.3715313581
MESH:D009369 Neoplasms pirinixic acid 19.3717405874
MESH:D009369 Neoplasms Quercetin 19.3715185748
MESH:D009369 Neoplasms sodium arsenite 19.3711559025
MESH:D009369 Neoplasms Tretinoin 19.3716946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 7.438985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.4320056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 9.2519196722
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.2512497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.1817289903
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.426375363
MESH:D009410 Nerve Degeneration Ibuprofen 11.8910961664
MESH:D009410 Nerve Degeneration Maneb 11.8915350641 16893418
MESH:D009410 Nerve Degeneration Paraquat 11.8916893418
MESH:D009421 Nervous System Malformations bisphenol A 31.4416427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 31.4411399458
MESH:D009421 Nervous System Malformations Estradiol 31.4411399458 16427766
MESH:D009421 Nervous System Malformations Genistein 31.4416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 31.4414600291
MESH:D009421 Nervous System Malformations Tretinoin 31.449125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.0618462866
MESH:D009436 Neural Tube Defects Arsenic 10.0016620997
MESH:D009436 Neural Tube Defects sodium arsenite 10.0012854658
MESH:D009436 Neural Tube Defects Tretinoin 10.009142499
MESH:D009447 Neuroblastoma irinotecan 3.178761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 11.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 11.4120387270
MESH:D019636 Neurodegenerative Diseases resveratrol 11.4117652729
MESH:D017599 Neuroectodermal Tumors irinotecan 4.178761367
MESH:D020078 Neurogenic Inflammation Arsenic 14.8517056641
MESH:D020078 Neurogenic Inflammation Quercetin 14.8517929310
MESH:D020078 Neurogenic Inflammation resveratrol 14.8517929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5520387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.399802331
MESH:D009765 Obesity Clozapine 6.5119142110 18515891
MESH:D009765 Obesity Curcumin 6.5119297423
MESH:D009765 Obesity pirinixic acid 6.5120558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.2816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.2816049721
MESH:D010003 Osteoarthritis Ibuprofen 3.787009135
MESH:D010024 Osteoporosis Curcumin 6.1518719352
MESH:D010024 Osteoporosis Genistein 6.1519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 13.9316169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 13.9319495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 13.9317513867
MESH:D010049 Ovarian Diseases bisphenol A 4.4311985600
MESH:D010051 Ovarian Neoplasms Arsenic 27.3017306315
MESH:D010051 Ovarian Neoplasms CD 437 27.3017474084
MESH:D010051 Ovarian Neoplasms Curcumin 27.3019020741 18462866
MESH:D010051 Ovarian Neoplasms decitabine 27.3019331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 27.3019401270
MESH:D010051 Ovarian Neoplasms Genistein 27.3019005980
MESH:D010051 Ovarian Neoplasms Quercetin 27.3019005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 27.3015276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 27.3016936753
MESH:D010146 Pain Acetaminophen 8.7216870215
MESH:D010146 Pain Ibuprofen 8.723291741
MESH:D010146 Pain Tretinoin 8.7216870215
MESH:D010149 Pain, Postoperative Ibuprofen 4.5816678543
MESH:D010190 Pancreatic Neoplasms Curcumin 21.2717440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms decitabine 21.2719294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 21.2716540662
MESH:D010190 Pancreatic Neoplasms Ethanol 21.2712384795
MESH:D010190 Pancreatic Neoplasms Ibuprofen 21.2712384795
MESH:D010190 Pancreatic Neoplasms Quercetin 21.2716965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 21.2715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1711578682
MESH:D010300 Parkinson Disease Maneb 5.2812911755 15824117 16140633 11124998 16510128
MESH:D010300 Parkinson Disease Paraquat 5.2815451049 16510128 12911755 16140633 11445065 15824117 11181820 11124998
MESH:D010302 Parkinson Disease, Secondary Paraquat 3.8916190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6812520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.6516093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.4315371236 6392382 16905509
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.6014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.1316977796 15687265
MESH:D011014 Pneumonia Paraquat 3.9012504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0318163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.662563599
MESH:D011230 Precancerous Conditions Quercetin 7.6619056647
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 18.7210548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 18.7217184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 18.7216679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 18.7211118676 11222880 11896295 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.1817616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.8920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.8920887781
MESH:D011471 Prostatic Neoplasms Arsenic 4.5416140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 4.5417292933
MESH:D011471 Prostatic Neoplasms bisphenol A 4.5416740699
MESH:D011471 Prostatic Neoplasms Curcumin 4.5411398177 12497104 18226269 18156803 18769126 15129424 10851300
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 4.5417136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 4.5416740699
MESH:D011471 Prostatic Neoplasms Genistein 4.5415256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Ibuprofen 4.5417409433
MESH:D011471 Prostatic Neoplasms Quercetin 4.5414715546 17292933
MESH:D011471 Prostatic Neoplasms resveratrol 4.5417675339 17718901 17804756 17636462 16731767 15767336
MESH:D011471 Prostatic Neoplasms sodium arsenite 4.5416039940
MESH:D011471 Prostatic Neoplasms Vitamin E 4.5415084515
MESH:D011507 Proteinuria Arsenic 12.6121343184
MESH:D011507 Proteinuria Ibuprofen 12.616375363
MESH:D011507 Proteinuria Tretinoin 12.6116636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.7616919318 15861022
MESH:D011595 Psychomotor Agitation Haloperidol 4.4111575062
MESH:D011618 Psychotic Disorders Clozapine 7.7915331141
MESH:D011618 Psychotic Disorders Haloperidol 7.7911575062
MESH:D011625 Pterygium Tretinoin 4.2416723453
MESH:D011629 Puberty, Precocious bisphenol A 4.2310548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.0419168576
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.0211597910 12490602 12832656
MESH:D011658 Pulmonary Fibrosis Paraquat 5.0216324872 17997886
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.0116325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.5719058328
MESH:D015427 Reperfusion Injury resveratrol 5.5716317513 16314181 17058453 17520802 15827377
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 7.5710666014 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 7.5711700416
MESH:D012135 Respiratory Sounds Paraquat 3.5211874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3118990726
MESH:D012162 Retinal Degeneration Paraquat 3.4416458197
MESH:D012208 Rhabdomyosarcoma decitabine 9.2419155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.2416283617 16116481
MESH:D012509 Sarcoma Curcumin 3.6318462866
MESH:D012554 Schistosomiasis japonica Quercetin 4.9816862918
MESH:D012559 Schizophrenia Clozapine 3.7417123785 20107430 20168265 11151749 19369910 20521320 17667964 11763009 16141801 20452607 18855531 17726453 18806925 20521326 20580759
MESH:D012559 Schizophrenia Haloperidol 3.7419369910 18513383 1830565 20107430
MESH:D012640 Seizures 2,4-dinitrotoluene 7.6118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 7.6118551238
MESH:D012640 Seizures Ethanol 7.619754883
MESH:D018805 Sepsis Curcumin 3.6218389075
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.5318724381
MESH:D012871 Skin Diseases Arsenic 4.4419834688 6392382 17548696 16759981 17938729 16702368 16353154 18709164 15952646 17453740 17050553
MESH:D012871 Skin Diseases Vitamin E 4.4418709164
MESH:D012878 Skin Neoplasms Arsenic 18.6817029826 19538983 17976673 16251483 17050553 15504454
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 18.6819755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 18.688985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 18.6819524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 18.6816192470
MESH:D012878 Skin Neoplasms Tretinoin 18.6816467112
MESH:D013088 Spermatocele Diethylstilbestrol 9.8316709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 9.8316709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3612854658
MESH:D013158 Splenic Diseases Grape Seed Proanthocyanidins 5.9312587719
MESH:D013272 Stomach Diseases Omeprazole 4.0618545984
MESH:D013274 Stomach Neoplasms marker/mechanism 15378696
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 9.172093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 9.1719037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 9.1718456281
MESH:D013274 Stomach Neoplasms Ethanol 9.1718456281
MESH:D013274 Stomach Neoplasms irinotecan 9.1715723263
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 9.1717575124 12958204
MESH:D013274 Stomach Neoplasms Tretinoin 9.1717261132
MESH:D013276 Stomach Ulcer Amiodarone 13.1918087811
MESH:D013276 Stomach Ulcer Curcumin 13.1916631530 19188055
MESH:D013276 Stomach Ulcer Ethanol 13.1911906479 17189318 17918041 9562338 9211565 16755016
MESH:D013276 Stomach Ulcer Omeprazole 13.1918237397 16755016 15991576 11906479 10750652 17977527
MESH:D020521 Stroke Vitamin E 3.0816517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.9916321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.4316684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.779754883
MESH:D013610 Tachycardia Amiodarone 3.7611238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 8.7819225199
MESH:D017180 Tachycardia, Ventricular Haloperidol 8.7820210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6815669648
MESH:D013959 Thyroid Diseases Amiodarone 10.1619731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.1612697716
MESH:D013964 Thyroid Neoplasms decitabine 13.6217967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 13.627505956
MESH:D013964 Thyroid Neoplasms Propylthiouracil 13.6215710170
MESH:D013964 Thyroid Neoplasms Tretinoin 13.6216026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 4.3218020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.1219048282
MESH:D014062 Tongue Neoplasms resveratrol 8.3016227395
MESH:D014062 Tongue Neoplasms Tretinoin 8.3016051514
MESH:D016171 Torsades de Pointes Amiodarone 3.6417467628 11989578
MESH:D014376 Tuberculosis Tretinoin 2.8616040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 36.3616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 36.3616049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 36.3615289314 1399818 15867355
MESH:D001749 Urinary Bladder Neoplasms Arsenic 36.3617976673 15987713 11144890 19429237 19322015 18640142 17306315
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 36.3617053015
MESH:D001749 Urinary Bladder Neoplasms CD 437 36.3616720286
MESH:D001749 Urinary Bladder Neoplasms Curcumin 36.3618593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 36.3619087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 36.3616712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Quercetin 36.3616720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 36.3616712894 16452187 11723127 17306315
MESH:D014565 Urogenital Neoplasms Curcumin 4.7118462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.1410091137
MESH:D014581 Urticaria Acetaminophen 2.4710982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 18.6716175088
MESH:D002583 Uterine Cervical Neoplasms resveratrol 18.6717473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 18.6711813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 18.6716129372
MESH:D014591 Uterine Diseases bisphenol A 11.9314652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 11.9314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 13.0216690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 13.0214692618
MESH:D014594 Uterine Neoplasms resveratrol 13.0217044934
MESH:D014604 Uveal Neoplasms decitabine 10.9417785578
MESH:D014604 Uveal Neoplasms Tretinoin 10.9416752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.8916513791 16002989
MESH:D014652 Vascular Diseases Arsenic 10.0017056641
MESH:D014652 Vascular Diseases sodium arsenite 10.0017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0312125929
MESH:D020301 Vasospasm, Intracranial Ibuprofen 4.6419057314
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0415869587 14671159
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.7617488730
MESH:D014820 Vitiligo Tretinoin 3.5316761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6815886252
MESH:D015430 Weight Gain Clozapine 4.0016402076 17502770 20564506 20107430 16141801 20521320
MESH:D015431 Weight Loss Clozapine 4.5217933447
MESH:D009396 Wilms Tumor Tretinoin 3.4916287080
Pathway ID Pathway Name
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:01100 Metabolic pathways
REACT:474 Metabolism of carbohydrates
KEGG:03018 RNA degradation
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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