AutismKB 2.0

Annotation Detail for ENO3


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Basic Information Top
Gene Symbol:ENO3 ( GSD13,MSE )
Gene Full Name: enolase 3 (beta, muscle)
Band: 17p13.2
Quick LinksEntrez ID:2027; OMIM: 131370; Uniprot ID:ENOB_HUMAN; ENSEMBL ID: ENSG00000108515; HGNC ID: 3354
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
ANARESP1-PWYrespiration (anaerobic)
GLYCOLYSISglycolysis I
PWY-5484glycolysis II
GLUCONEO-PWYgluconeogenesis I
ANAGLYCOLYSIS-PWYglycolysis III
Pathway IDPathway Name
hsa00010Glycolysis / Gluconeogenesis
hsa03018RNA degradation
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of carbohydrates
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Glycogen storage disease XIII
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063609 1,2-dimethyl-4-nitrobenzene 1,2-dimethyl-4-nitrobenzene results in increased expression of ENO3 mRNAincreases expression 19784758
D000082 Acetaminophen Acetaminophen affects the expression of ENO3 mRNAaffects expression 19784758
D000082 Acetaminophen Acetaminophen results in decreased expression of ENO3 mRNAdecreases expression 19784758
D000082 Acetaminophen Acetaminophen results in increased expression of ENO3 mRNAincreases expression 19784758
C430898 AGN 194204 AGN 194204 results in increased expression of ENO3 mRNAincreases expression 16339527
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ENO3 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ENO3 mRNAincreases expression 17484886
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of ENO3 mRNA]affects binding|increases expression|increases reaction 16940432
C004742 daidzein daidzein results in decreased expression of ENO3 mRNAdecreases expression 15757668
D004317 Doxorubicin [Doxorubicin co-treated with MT2A protein] results in decreased expression of ENO3 proteinaffects cotreatment|decreases expression 16144979
D004958 Estradiol Estradiol results in decreased expression of ENO3 mRNAdecreases expression 15757668
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ENO3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENO3 mRNAaffects cotreatment|increases expression 17942748
D019833 Genistein Genistein results in decreased expression of ENO3 mRNAdecreases expression 15757668
C001654 hyperforin hyperforin affects the expression of ENO3 proteinaffects expression 15095150
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of ENO3 mRNA]affects binding|increases expression|increases reaction 16940432
C029938 nickel sulfate nickel sulfate affects the expression of ENO3 mRNAaffects expression 12718980
D009578 Nitrobenzenes Nitrobenzenes analog results in increased expression of ENO3 mRNAincreases expression 19784758
D010081 Oxazolone Oxazolone results in increased expression of ENO3 mRNAincreases expression 11379042
D010126 Ozone Ozone results in decreased expression of ENO3 mRNAdecreases expression 12763052
C008776 pelargonic acid pelargonic acid results in decreased expression of ENO3 mRNAdecreases expression 11379042
D010656 Phenylephrine Phenylephrine results in increased expression of ENO3 mRNAincreases expression 18158353
C006253 pirinixic acid pirinixic acid results in increased expression of ENO3 mRNAincreases expression 17426115
C059514 resveratrol resveratrol results in decreased expression of ENO3 mRNAdecreases expression 15582268
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENO3 mRNAaffects cotreatment|increases expression 17942748
D013853 Thioacetamide Thioacetamide results in increased expression of ENO3 mRNAincreases expression 19784758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7014514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D058186 Acute Kidney Injury resveratrol 3.7116538975
MESH:D055371 Acute Lung Injury nickel sulfate 8.6711954676 16100012 19131640 12718980
MESH:D055371 Acute Lung Injury pirinixic acid 8.6718653653
MESH:D000230 Adenocarcinoma daidzein 13.1611473722
MESH:D000230 Adenocarcinoma Doxorubicin 13.1617418594
MESH:D000230 Adenocarcinoma Estradiol 13.1611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 13.1614692618
MESH:D000230 Adenocarcinoma Genistein 13.1611473722
MESH:D000236 Adenoma resveratrol 3.2315688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3916835633
MESH:D000419 Albuminuria Doxorubicin 4.4021441931
MESH:D000544 Alzheimer Disease Ozone 4.2715513908
MESH:D000544 Alzheimer Disease resveratrol 4.2716162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9817460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.0515885639
MESH:D001169 Arthritis, Experimental resveratrol 7.0517115116
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5215570426
MESH:D001249 Asthma Ozone 2.5917854713 16373670
MESH:D050197 Atherosclerosis resveratrol 3.1817967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.5419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.5412125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 14.5419483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5514601052
MESH:D001919 Bradycardia Phenylephrine 4.3915306635
MESH:D002545 Brain Ischemia resveratrol 4.1317600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.6817150277
MESH:D001943 Breast Neoplasms Chromium 2.9015986119
MESH:D001943 Breast Neoplasms Doxorubicin 2.9011325840 18234424 15567936 15668708 15994142 16096432 17426702 15993339 16322301 18695136 17369602 19526202 16115903 15136595 17983394 15939500 16595493 16264153 15634643 15692762 18382427 16826403 16935488 18628466
MESH:D001943 Breast Neoplasms Estradiol 2.9017018787 16675129 14630087 17289903 18497071 12948864 19861407 17261762
MESH:D001943 Breast Neoplasms Genistein 2.9017200150 16873071 16541309
MESH:D001943 Breast Neoplasms resveratrol 2.9017651959 17534123 16393696
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9020435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5616777450 14754758 18417511 19059883 15516495 18315731 17626835
MESH:D002100 Cachexia Ozone 4.5916183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6316011737 15673190 16124888 15721981 18705752 15700767 3786805 16227642 10355542 16050911 16097048 16192424
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6616051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.723084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.7218788625
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 13.7216023760 18059187 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.7216924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.7216924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 13.7216227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 13.7217997003
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4416675471
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.091485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.796189445
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.7916227395
MESH:D006332 Cardiomegaly Phenylephrine 6.6015728586 11754973 17124262 11179087 16170337 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.6018670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.4317924179 16731534 16278810 15505089 15811867 16109756 17131338 15476868 17329180 17519947 16364871 16269455 16242529 17308081 16952015 16651473 15792986 17974986 17928571 17382496 16612575 17351982 16455267 18627295 17007740
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8916243910 17334414
MESH:D002318 Cardiovascular Diseases daidzein 11.7616332659
MESH:D002318 Cardiovascular Diseases Genistein 11.7616332659
MESH:D002318 Cardiovascular Diseases resveratrol 11.7615458977
MESH:D002386 Cataract Acetaminophen 2.4910977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.6718566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.1216835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.1218291259
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3716105132 11677210 17681005 15861022 16919318 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 7.3719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0416354765 15668235 8697196 12621046 15340226
MESH:D003092 Colitis resveratrol 3.9816474422
MESH:D003110 Colonic Neoplasms Genistein 3.8417182828
MESH:D003110 Colonic Neoplasms resveratrol 3.8416338953
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.7018259882 18802399
MESH:D015179 Colorectal Neoplasms resveratrol 2.7016550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9317141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.6616507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 10048152 20055451
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.5311298694 16780908 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003877 Dermatitis, Contact Oxazolone 4.9512811023 15944321
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6416873680
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 7.0516647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 7.0516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.0517107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.5919279558
MESH:D003928 Diabetic Nephropathies resveratrol 8.5916286809
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.5314550746 11287661 16393943 12705907 11743745 18071297 10774834 10915739 12540782 16781746 16485898 11421492 19370779 19416960 17562736 17522070 11529661 17906064 14986274 11461765 19164858 16177239 16227642 19085960 10663392 15968718 12153990 19739265 19923254 16081117 12594235 12958197 15619225 16109766 11739529 14725611 12392966 19420014 11834606 18713872 2444490
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.534309450 11566570 21278145 15027814 17522070 10915739 9327722 7120509 15968718 15998439 2869522 19336974 16177239 6623471 19085960 10092053 7440962 3786805 16227642 6884620 3732212 7179309
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.5317416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.5320420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 11.5312963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Doxorubicin 7.7418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.7411462148
MESH:D004487 Edema pirinixic acid 10.6312083418
MESH:D004487 Edema resveratrol 10.638985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.6312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7516714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.6312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 8.6317872969
MESH:D004714 Endometrial Hyperplasia Genistein 4.4416402032
MESH:D016889 Endometrial Neoplasms daidzein 17.0511473722
MESH:D016889 Endometrial Neoplasms Doxorubicin 17.0517359293
MESH:D016889 Endometrial Neoplasms Estradiol 17.0511473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 17.0511473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8910568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0118037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7017923197
MESH:D007172 Erectile Dysfunction daidzein 4.8714972507
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005218 Fat Necrosis Thioacetamide 5.5716456712
MESH:D005234 Fatty Liver Carbon Tetrachloride 12.2415959796 19224547 12631006 61145 16239168 12795759 16045604 17595544
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.2415345470
MESH:D005234 Fatty Liver pirinixic acid 12.2420131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4419069698
MESH:D005355 Fibrosis Carbon Tetrachloride 8.1018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1020067830
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D005909 Glioblastoma Doxorubicin 7.0117150277
MESH:D005909 Glioblastoma Genistein 7.0116598420
OMIM:612932 GLYCOGEN STORAGE DISEASE XIII marker/mechanism
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.4315692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2510048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.3816144979 16495754 16879835 18006777 14766674 16244372 17888722 17875725 16330681 18674790 12587719 16707910 16244371
MESH:D006333 Heart Failure Doxorubicin 6.7417481944
MESH:D006333 Heart Failure pirinixic acid 6.7420558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7615692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.4318665440 17276928 15929193
MESH:D006505 Hepatitis Carbon Tetrachloride 8.9919110552 19900420
MESH:D006505 Hepatitis Thioacetamide 8.9916456712
MESH:D006529 Hepatomegaly pirinixic acid 7.7616221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7615340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D006561 Herpes Simplex resveratrol 4.0316876885
MESH:D006689 Hodgkin Disease Doxorubicin 3.2815147373 17606976 18501091
MESH:D019584 Hot Flashes Estradiol 3.6017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.898697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
MESH:D006937 Hypercholesterolemia resveratrol 3.8717188708
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006949 Hyperlipidemias resveratrol 3.8916873680
MESH:D006973 Hypertension daidzein 8.4917169123
MESH:D006973 Hypertension Phenylephrine 8.498949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.4918670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D006984 Hypertrophy Phenylephrine 4.4218502941 12791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1717488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6616569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.5017600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3917937319
MESH:D007249 Inflammation resveratrol 4.8116366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8112878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.3916624496
MESH:D007333 Insulin Resistance Estradiol 6.8716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.8716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007674 Kidney Diseases Acetaminophen 13.7915629191 12587719
MESH:D007674 Kidney Diseases Chromium 13.7917934191
MESH:D007674 Kidney Diseases Doxorubicin 13.7915369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 13.7915618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0116707910
MESH:D007680 Kidney Neoplasms Estradiol 2.8615610895
MESH:D007938 Leukemia Genistein 2.9517468513 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0116085563
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4816087638
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7316943688 16239168 11408273 11903743 21278145 17157831 17174718 16221502 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.6412649538 18429990 18277467 15338365 17823541 16248980 17708605 18339082 17976157 12898905 18054572 18210741 18263696 15123356 16638106 12632514 18395095 18412020 14512876 18279442 18251166 17721639 17698563 17805973 18420326 10355542 18472094 16027843 17761835 18205269 14620537 15362042 16011737 18395914 15370692 18418968 16015684 12667390 12609069 17525996 14748882 15052691 12389079 17640975 18472332 12445421 18006644 12741479 17922224 20821823 12546737 11481614 17557913 16033810 12666154 15893842 15931870 15876570 15959796 15650968 15925388 16192424 14716496 12632512 15730626 17631135 18376398 14724832 15673190 12958196 16136751 15996030 17481882 17900296 17714472 16116963 12445418 18705752 14716833 15057751 17869086 17766677 15818738 17944888 18317297 18156304 17565644 18187930 13678700 16097048 18166357 18481824 12586293
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 10.6416439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.6414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 10.6417823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.6415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.6412878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 10.6416098781 17629604 18416461 15474484 11481614 17292413 15334695 15716488 12891558 18395095 12531686 18263696 17050028 15158331 15288473 11682029 15075984 15288472 12085344 17127702 10677585 15078482 16097051 18032466 18606216 15316131 14739098 17355460 12679928 15095483 15465738 18031379 16248980 18380797 15362042 18295389 12557150 16126171 16511523 11172339 18458672 16343077 12175628 18615449 16489207
MESH:D008107 Liver Diseases marker/mechanism 19784758
MESH:D008107 Liver Diseases Acetaminophen 6.3212587719 19784758 11587558 19014921 16610002 19460945 16611625 12969438
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.3215720792 16246199 17285989 15830285 16964402
MESH:D008107 Liver Diseases Thioacetamide 6.3216337175 18374380 15158337
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 15.4816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 15.4814706259 16899240
MESH:D017114 Liver Failure, Acute Thioacetamide 15.4812479984 15633222 15313186 17276928
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.2219294768
MESH:D008113 Liver Neoplasms pirinixic acid 10.2216377806 15890375 20007298
MESH:D008113 Liver Neoplasms resveratrol 10.2219073162 19812893 19321006 20405173
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.2216984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.3012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.3016842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.3012151625
MESH:D008171 Lung Diseases Ozone 3.2719066396 8266340
MESH:D055370 Lung Injury Ozone 3.7020417186
MESH:D008175 Lung Neoplasms Doxorubicin 3.3717418594 6189445
MESH:D008175 Lung Neoplasms Ozone 3.378597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3719555203 11884234
MESH:D008223 Lymphoma Doxorubicin 3.3516098063
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1617088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.4617654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 8.4614749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4215621674
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.0915688416
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 13.5115458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.5111807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 13.5114578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 13.518985016 11606380
MESH:D020149 Manganese Poisoning Estradiol 4.3319453300
MESH:D008545 Melanoma Doxorubicin 3.5016827129
MESH:D008545 Melanoma resveratrol 3.5017992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008654 Mesothelioma Doxorubicin 3.0017638057
MESH:D008659 Metabolic Diseases resveratrol 4.2417112576
MESH:D008679 Metaplasia Ozone 4.9610496685
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3615792986
MESH:D052016 Mucositis Doxorubicin 4.6417415656
MESH:D009101 Multiple Myeloma resveratrol 3.3616267019 17049120 17935668 16490592 17164350 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.7217962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009203 Myocardial Infarction Doxorubicin 13.0619429709 15857846
MESH:D009203 Myocardial Infarction Genistein 13.0617141266
MESH:D009203 Myocardial Infarction pirinixic acid 13.0619151258
MESH:D009203 Myocardial Infarction resveratrol 13.0616525036 17015251 17188708 16317513 16456233 17125593
MESH:D017202 Myocardial Ischemia resveratrol 8.6117015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.6112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.5016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.5017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.5016411023
MESH:D009205 Myocarditis resveratrol 4.6117322642
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.8918259882
MESH:D009369 Neoplasms pirinixic acid 1.8817405874
MESH:D009374 Neoplasms, Experimental resveratrol 3.858985016
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5817289903
MESH:D009401 Nephrosis Doxorubicin 4.6216899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8715640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 15.5116427766 11399458
MESH:D009421 Nervous System Malformations Genistein 15.5116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.5114600291
MESH:D009447 Neuroblastoma Doxorubicin 3.1915555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.9418514411
MESH:D019636 Neurodegenerative Diseases resveratrol 7.9417652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.2617929310
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D010024 Osteoporosis Genistein 3.1619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.6816169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.6817513867
MESH:D012516 Osteosarcoma Doxorubicin 3.9915930896
MESH:D010051 Ovarian Neoplasms Estradiol 4.7419401270
MESH:D010051 Ovarian Neoplasms Genistein 4.7419005980
MESH:D010146 Pain Acetaminophen 2.2716870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010538 Peritonitis Ozone 3.9816369182
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0117983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0117638057
MESH:D011014 Pneumonia Ozone 4.2418381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.0816679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0811896295 11222880 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7520887781
MESH:D011471 Prostatic Neoplasms AGN 194204 1.9016000583
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9016729912 15749863 15897917 16888761 16868541 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 1.9016740699
MESH:D011471 Prostatic Neoplasms Genistein 1.9015378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms resveratrol 1.9017718901 17675339 16731767 17804756 15767336 17636462
MESH:D011537 Pruritus Ethinyl Estradiol 3.1615861022 16919318
MESH:D051437 Renal Insufficiency Doxorubicin 4.0717922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.4316325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.3319058328
MESH:D015427 Reperfusion Injury resveratrol 6.3315827377 16317513 17520802 16314181 17058453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012509 Sarcoma Doxorubicin 3.8617203757 15625365 15675481 16767912 17710206 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.0916326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6417846226
MESH:D012852 Sinusitis Phenylephrine 4.557327846
MESH:D012878 Skin Neoplasms Doxorubicin 9.1115692506
MESH:D012878 Skin Neoplasms resveratrol 9.118985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.1116192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4216767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7916709447
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3516321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.2617909728 16010429
MESH:D013978 Tibial Fractures Estradiol 4.5319048282
MESH:D014062 Tongue Neoplasms resveratrol 4.0816227395
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.7117653716
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.9717473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.0114692618
MESH:D014594 Uterine Neoplasms resveratrol 9.0117044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4014671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 9.8417334414 16364871 17678736 17638931
MESH:D018487 Ventricular Dysfunction, Left resveratrol 9.8417488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
Pathway ID Pathway Name
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:01100 Metabolic pathways
REACT:474 Metabolism of carbohydrates
KEGG:03018 RNA degradation
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01819 - Phosphoenolpyruvate
DB02389 - Phosphoglycolic Acid
DB03465 - 2-Phospho-D-Glyceric Acid
DB03645 - Phosphonoacetohydroxamic Acid
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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