AutismKB 2.0

Annotation Detail for SLC29A1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC29A1 ( ENT1,MGC1465,MGC3778 )
Gene Full Name: solute carrier family 29 (nucleoside transporters), member 1
Band: 6p21.1
Quick LinksEntrez ID:2030; OMIM: 602193; Uniprot ID:S29A1_HUMAN; ENSEMBL ID: ENSG00000112759; HGNC ID: 11003
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of nucleotides
Transmembrane transport of small molecules
No data
No data
Pathway IDPathway Name
500224Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1809HIV infection
1895Gestational diabetes
2051Leukemia
2161Hodgkin's disease
2238Lipodystrophy
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SLC29A1 mRNAdecreases expression 16984957
C001789 4-nitrobenzylthioinosine 4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in decreased susceptibility to Fluorouracil]decreases reaction|decreases response to substance 17695509
C001789 4-nitrobenzylthioinosine 4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of gemcitabine]decreases reaction|increases uptake 17695509
D000082 Acetaminophen Acetaminophen affects the expression of SLC29A1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC29A1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC29A1 mRNAaffects expression 16483693
D003561 Cytarabine SLC29A1 gene polymorphism results in decreased susceptibility to Cytarabinedecreases response to substance 18381442
D002945 Cisplatin SLC29A1 protein affects the susceptibility to Cisplatinaffects response to substance 18728667
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of SLC29A1 mRNAdecreases expression 15289156
D004317 Doxorubicin SLC29A1 protein affects the susceptibility to Doxorubicinaffects response to substance 18452103
D004958 Estradiol Estradiol results in decreased expression of SLC29A1 mRNAdecreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SLC29A1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC29A1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SLC29A1 mRNAdecreases expression 17351261
D005472 Fluorouracil 4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in decreased susceptibility to Fluorouracil]decreases reaction|decreases response to substance 17695509
D005472 Fluorouracil Fluorouracil promotes the reaction [SLC29A1 protein results in increased uptake of gemcitabine]increases reaction|increases uptake 16868479
D005472 Fluorouracil Fluorouracil results in increased expression of SLC29A1increases expression 18383843
D005472 Fluorouracil Fluorouracil results in increased expression of SLC29A1 mRNAincreases expression 16868479
D005472 Fluorouracil SLC29A1 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D005472 Fluorouracil SLC29A1 protein results in decreased susceptibility to Fluorouracildecreases response to substance 17695509
C056933 fumonisin B1 fumonisin B1 results in decreased expression of SLC29A1 mRNAdecreases expression 16221962
C056507 gemcitabine 4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of gemcitabine]decreases reaction|increases uptake 17695509
C056507 gemcitabine Fluorouracil promotes the reaction [SLC29A1 protein results in increased uptake of gemcitabine]increases reaction|increases uptake 16868479
C056507 gemcitabine [S 1 (combination) results in increased expression of SLC29A1 mRNA] which results in increased uptake of gemcitabineincreases expression|increases uptake 18383843
C056507 gemcitabine SLC29A1 mRNA results in increased susceptibility to gemcitabineincreases response to substance 18490900
C056507 gemcitabine SLC29A1 protein affects the susceptibility to gemcitabineaffects response to substance 18452103
18728667
C056507 gemcitabine SLC29A1 protein results in decreased susceptibility to gemcitabinedecreases response to substance 17695509
C056507 gemcitabine SLC29A1 protein results in increased susceptibility to gemcitabineincreases response to substance 18992248
C056507 gemcitabine SLC29A1 protein results in increased uptake of gemcitabineincreases uptake 18992248
16868479
17695509
18383843
D019833 Genistein Genistein results in decreased expression of SLC29A1 mRNAdecreases expression 15289156
D010656 Phenylephrine Phenylephrine results in increased expression of SLC29A1 mRNAincreases expression 19966059
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC29A1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of SLC29A1 mRNAdecreases expression 16221962
18445702
C079198 S 1 (combination) S 1 (combination) results in increased expression of SLC29A1 mRNAincreases expression 18383843
C079198 S 1 (combination) [S 1 (combination) results in increased expression of SLC29A1 mRNA] which results in increased uptake of gemcitabineincreases expression|increases uptake 18383843
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of SLC29A1 mRNAaffects cotreatment|increases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC29A1 mRNAaffects cotreatment|increases expression 17942748
C096910 UFT(R) drug UFT(R) drug results in increased expression of SLC29A1 mRNAincreases expression 16868479
D014529 Uridine SLC29A1 protein results in increased uptake of Uridineincreases uptake 18381442
C025643 vinclozolin vinclozolin affects the expression of SLC29A1 mRNAaffects expression 19015723
C030852 vinorelbine SLC29A1 protein affects the susceptibility to vinorelbineaffects response to substance 18452103
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of SLC29A1 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of SLC29A1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.7912690470 17670903 15814532
MESH:D055371 Acute Lung Injury pirinixic acid 2.9418653653
MESH:D000230 Adenocarcinoma Cisplatin 16.4917638652 11798837
MESH:D000230 Adenocarcinoma Doxorubicin 16.4917418594
MESH:D000230 Adenocarcinoma Estradiol 16.4911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 16.4914692618
MESH:D000230 Adenocarcinoma Fluorouracil 16.4917638652
MESH:D000230 Adenocarcinoma Genistein 16.4911473722
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 16.3416628245
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.3416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.3416835633
MESH:D000419 Albuminuria Doxorubicin 4.3621441931
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3015469931
MESH:D000740 Anemia Fluorouracil 8.1316511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.1311748828
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4919015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9517460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5515885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.1919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.1912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 11.4114601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 11.4114601052
MESH:D001919 Bradycardia Phenylephrine 4.3515306635
MESH:D001932 Brain Neoplasms Doxorubicin 3.6417150277
MESH:D001943 Breast Neoplasms Cisplatin 5.6519526202 18382427
MESH:D001943 Breast Neoplasms Diethylstilbestrol 5.6517129689 15324884
MESH:D001943 Breast Neoplasms Doxorubicin 5.6516096432 15939500 18695136 18382427 19526202 17426702 15668708 15567936 16264153 15136595 18234424 15692762 17983394 15994142 17369602 15634643 16115903 15993339 11325840 16322301 18628466 16935488 16595493 16826403
MESH:D001943 Breast Neoplasms Estradiol 5.6517289903 17261762 12948864 16675129 14630087 19861407 17018787 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 5.6516557594 15136595 16595493 19217205 18608205 18357371 16110121
MESH:D001943 Breast Neoplasms gemcitabine 5.6518382427 17039268
MESH:D001943 Breast Neoplasms Genistein 5.6517200150 16541309 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.6520435547
MESH:D001943 Breast Neoplasms vinorelbine 5.6516495393
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2716111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.7416050911
MESH:D002276 Carcinoid Tumor Doxorubicin 11.7116051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.7116051944
MESH:D002277 Carcinoma Fluorouracil 7.6917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.383084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.3821507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 16.3817982673
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 16.3815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 16.3816023760 18059187 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.3816924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.3817088986 16799960 17045692 18930000 16332177 17971768
MESH:D006528 Carcinoma, Hepatocellular Genistein 16.3816924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 9.0912023789 16685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 9.0918347146 18212800
MESH:D002289 Carcinoma, Non-Small-Cell Lung vinorelbine 9.0918758305
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.381485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.3818695887
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 10.4518337622 17066447 6189445
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.456189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.4518986760 16280240 17066447 16757204
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 10.4515984520
MESH:D006332 Cardiomegaly Phenylephrine 6.5311179087 15728586 16170337 17124262 17287366 11754973
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.5316120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.4117329180 16109756 18627295 17974986 17308081 16952015 16242529 15811867 16364871 17924179 15476868 15792986 17351982 16731534 16455267 17382496 17519947 17928571 17131338 16612575 16269455 17007740 15505089 16651473 16278810
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8816243910 17334414
MESH:D002318 Cardiovascular Diseases Genistein 3.1716332659
MESH:D002386 Cataract Acetaminophen 2.4710977129
MESH:D002471 Cell Transformation, Neoplastic Cytarabine 6.788243401
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7818566989
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 9.2816628245
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.2816105132 17110522 17333356 15861022 17681005 16919318 11677210
MESH:D002779 Cholestasis pirinixic acid 7.2819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.038697196 12621046 15668235 15340226 16354765
MESH:D003092 Colitis Selenium 3.5917936198
MESH:D003110 Colonic Neoplasms Fluorouracil 3.7316510598 17287894 18772588 17018589 15001691 17172411 17725105 17169374 16340194 17016597
MESH:D003110 Colonic Neoplasms Genistein 3.7317182828
MESH:D015179 Colorectal Neoplasms Cisplatin 3.4415273666
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.4418802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.4416391804 17255274 18448328 17454858 17401013 15289873 20501625 16303861 18802399 18288408 16524972 18949393 17695437 17594712 16282729 18383874 16331619 17094418 17016601 14970324 15148649 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9017141729 14669216
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 3.8217686920
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8220055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8219769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 10.7612952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 10.7614966744
MESH:D007644 Darier Disease Fluorouracil 4.6016733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.1716647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2519279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.4117522070 16393943 16109766 11287661 14986274 19164858 12392966 16485898 16081117 11461765 11834606 19416960 12958197 12594235 16781746 19739265 14725611 11739529 16227642 12540782 15968718 10663392 19085960 19370779 12705907 19420014 11421492 10915739 10774834 19923254 15619225 2444490 16177239 14550746 18713872 12153990 18071297 11529661 11743745 17562736 17906064
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.4117416283
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 11.4116221962
MESH:D056486 Drug-Induced Liver Injury Selenium 11.4115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.4120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Cisplatin 12.9612231392 19839026 15033597 12649298
MESH:D004362 Drug Toxicity Doxorubicin 12.9618602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.9611462148
MESH:C538011 Eales disease Vitamin E 4.519068938
MESH:D004487 Edema pirinixic acid 5.9712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.9712711302 11000095
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 11.7717686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.7718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0112538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.2516402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.2516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.8015700306 16804899
MESH:D016889 Endometrial Neoplasms Doxorubicin 16.8017359293
MESH:D016889 Endometrial Neoplasms Estradiol 16.8018566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 16.8011473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8610568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9618037988
MESH:D004938 Esophageal Neoplasms Cisplatin 4.6017638652 15464296 16481741 15173087 16785472
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6016481741 17638652 16337965 15173087 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 6.9715345470
MESH:D005234 Fatty Liver pirinixic acid 6.9720131406 19236843
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5416534752 16611131 15751030 16513791 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4019069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.7620067830
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 5.5819093184
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7416973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1116417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7516452187
MESH:D005909 Glioblastoma Doxorubicin 6.9317150277
MESH:D005909 Glioblastoma Genistein 6.9316598420
MESH:D005910 Glioma Fluorouracil 2.7916145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 17.5015102660 15464296
MESH:D006258 Head and Neck Neoplasms Doxorubicin 17.5015692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 17.5018337622 15102660 15162350
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 17.5015984520 18607998
MESH:D034381 Hearing Loss Cisplatin 4.1319898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2615464296
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 10.7320471113 17686920
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.7311294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 10.7316080930
MESH:D006331 Heart Diseases Doxorubicin 3.3516879835 16244372 14766674 16330681 16244371 16707910 16144979 12587719 16495754 17888722 18006777 17875725 18674790
MESH:D006333 Heart Failure Doxorubicin 11.1317481944
MESH:D006333 Heart Failure pirinixic acid 11.1320558911
MESH:D006333 Heart Failure Selenium 11.1317162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7315692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006529 Hepatomegaly fumonisin B1 13.3916221962
MESH:D006529 Hepatomegaly pirinixic acid 13.3916221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.3912621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6416490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.8415709030
MESH:D006689 Hodgkin Disease Cisplatin 11.5816200630 16170182
MESH:D006689 Hodgkin Disease Cytarabine 11.5816200630
MESH:D006689 Hodgkin Disease Doxorubicin 11.5815147373 18501091 17606976
MESH:D019584 Hot Flashes Estradiol 9.4117088409
MESH:D019584 Hot Flashes Vitamin E 9.4114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8516959395 8697196 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.5516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2514722030 12960047
MESH:D006973 Hypertension Phenylephrine 5.068949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0618670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.3812791704 18502941
MESH:D007021 Hypospadias Diethylstilbestrol 10.6116002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.6116569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.1715036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2417937319
MESH:D007248 Infertility, Male vinclozolin 6.2416467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.7612878042 12200463
MESH:D007251 Influenza, Human Selenium 10.3116624496
MESH:D007251 Influenza, Human Vitamin E 10.3116624496
MESH:D007333 Insulin Resistance Estradiol 6.7916627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.7916306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.9515464296
MESH:D007674 Kidney Diseases Acetaminophen 17.9115629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 17.9119839026 12649298 18289764 12231392 15190930
MESH:D007674 Kidney Diseases Doxorubicin 17.9116775033 15369732 15699352
MESH:D007674 Kidney Diseases Estradiol 17.9115618244
MESH:D007674 Kidney Diseases Vitamin E 17.9112488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.4116707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.4116518626
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.6114681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 11.6115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 11.6116985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.6011231351
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8717184923
MESH:D007938 Leukemia Genistein 2.9318980019 17468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9616085563
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5416417039
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.4216595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.4214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.4217823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.4212878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.4216169303
MESH:D008107 Liver Diseases Acetaminophen 1.5912969438 11587558 19460945 16610002 19784758 12587719 19014921 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0717185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.4715890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Diethylstilbestrol 13.4716712894 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 13.4715113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 13.4715890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.4716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.188603461
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.1816842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.1812151625
MESH:D008171 Lung Diseases Vitamin E 3.0516863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.2414755239
MESH:D008175 Lung Neoplasms Cisplatin 8.2417225452 11798837 6189445
MESH:D008175 Lung Neoplasms Doxorubicin 8.2417418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 8.2415246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2419555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 8.2411062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6015086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9615166399
MESH:D008223 Lymphoma Diethylstilbestrol 7.3015700306
MESH:D008223 Lymphoma Doxorubicin 7.3016098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3815621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3216002989
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 13.2915458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.2911408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 13.2914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Selenium 13.2915318939
MESH:D020149 Manganese Poisoning Estradiol 4.2919453300
MESH:D008545 Melanoma Cisplatin 3.5216248763 12393984 11135225 16432458 15577323 18176117 12883367 12374674 17023156 16809738 18332650 18505091 17761969
MESH:D008545 Melanoma Doxorubicin 3.5216827129
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.5815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008654 Mesothelioma Cisplatin 9.8217638057
MESH:D008654 Mesothelioma Doxorubicin 9.8217638057
MESH:D008654 Mesothelioma Selenium 9.8215107826
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3215792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4916757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.6017415656
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009203 Myocardial Infarction Doxorubicin 9.0315857846 19429709
MESH:D009203 Myocardial Infarction Genistein 9.0317141266
MESH:D009203 Myocardial Infarction pirinixic acid 9.0319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.3316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.3317141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.3316411023
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.8818259882
MESH:D009369 Neoplasms Cisplatin 11.1316773208
MESH:D009369 Neoplasms Diethylstilbestrol 11.1315313581
MESH:D009369 Neoplasms Fluorouracil 11.1318239605 16928823 18600527
MESH:D009369 Neoplasms pirinixic acid 11.1317405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5417289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.3015464296
MESH:D009401 Nephrosis Doxorubicin 4.5816636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8415640375 16889571
MESH:D009421 Nervous System Malformations Diethylstilbestrol 21.9411399458
MESH:D009421 Nervous System Malformations Estradiol 21.9416427766 11399458
MESH:D009421 Nervous System Malformations Genistein 21.9416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.9414600291
MESH:D009447 Neuroblastoma Cisplatin 6.828761367
MESH:D009447 Neuroblastoma Doxorubicin 6.8215555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7218514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.518761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3116436463
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D010024 Osteoporosis Genistein 3.1419401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9116169203
MESH:D012516 Osteosarcoma Doxorubicin 3.9615930896
MESH:D010051 Ovarian Neoplasms Cisplatin 7.616897625 17225452 19769630 15464296
MESH:D010051 Ovarian Neoplasms Estradiol 7.6119401270
MESH:D010051 Ovarian Neoplasms Genistein 7.6119005980
MESH:D010146 Pain Acetaminophen 2.2416870215
MESH:D010190 Pancreatic Neoplasms marker/mechanism 18728667
MESH:D010190 Pancreatic Neoplasms Cisplatin 8.4519003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.4515113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms gemcitabine 8.4516929163 17440100 18383843 18992248 11504793
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.1215464296
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9617983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9814722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4816977796 15687265
MESH:D010954 Plasmacytoma Selenium 4.7015087411
MESH:D010997 Pleural Neoplasms Cisplatin 13.2917638057
MESH:D010997 Pleural Neoplasms Doxorubicin 13.2917638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cytarabine 4.3421297632
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 15.1617184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.1611399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 15.1619015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.7418220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7120887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0817136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.0818437689 16729912 15749863 15897917 16868541 16888761
MESH:D011471 Prostatic Neoplasms Estradiol 2.0816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0819082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 2.0815256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms vinorelbine 2.0816888761
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0815084515
MESH:D011472 Prostatitis vinclozolin 4.7418629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.1215861022 16919318
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8518286688 15538739 16160472 18722050
MESH:D051437 Renal Insufficiency Cisplatin 9.7515464296
MESH:D051437 Renal Insufficiency Doxorubicin 9.7517922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012509 Sarcoma Doxorubicin 3.8217203757 15625365 17710206 15675481 18313854 16767912
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.8414601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.8416326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6017846226
MESH:D012852 Sinusitis Phenylephrine 4.517327846
MESH:D012871 Skin Diseases Vitamin E 2.3918709164
MESH:D012878 Skin Neoplasms Doxorubicin 5.3915692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3916192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.1515464296
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3817203757 15625365 16767912
MESH:D013088 Spermatocele Diethylstilbestrol 11.0716002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 11.0716709447
MESH:D013274 Stomach Neoplasms Cisplatin 3.5717522103 15958060 18396642
MESH:D013274 Stomach Neoplasms Fluorouracil 3.5716951190 16424979 19015929 18567086 18396642 17498489 19084572 17172411 15786421 17522103
MESH:D013274 Stomach Neoplasms S 1 (combination) 3.5716557585 18506536 18553229
MESH:D020521 Stroke Vitamin E 3.3716517955
MESH:D013736 Testicular Neoplasms Cisplatin 4.4515464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.2317909728 16010429
MESH:D013978 Tibial Fractures Estradiol 4.4919048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8216280240
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.0615464296 17225452 12973940
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.0616452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.0617653716
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 15.0016803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 15.0016175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 15.0016803524
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9814652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.8615809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.8614692618
MESH:D014625 Vaginal Neoplasms Cisplatin 10.4515577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 10.4516513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0317334414 17638931 17678736 16364871
MESH:D014839 Vomiting Cisplatin 4.5311897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
Pathway ID Pathway Name
REACT:1698 Metabolism of nucleotides
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA154
    • Releated gene ID Related gene Name
    PA154SLC29A1
    Releated disease ID Related disease Name
    PA444760Leukemia, Myeloid, Acute
    PA446166Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
    PA128407012cancer or viral infections
    PA444818Lung Neoplasms
    PA445062Neoplasms
    PA445218Pancreatic Neoplasms
    PA443756Colonic Neoplasms
    PA444283Glioblastoma
    PA443622Carcinoma, Non-Small-Cell Lung
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA448771capecitabine
    PA448515azathioprine
    PA449177cytarabine
    PA152530737dilazep
    PA449367dipyridamole
    PA128406956fluorouracil
    PA449748gemcitabine
    PA451241ribavirin
    PA152530738tubercidin
    PA452628nucleosides and nucleotides excl. reverse transcriptase inhibitors
    PA449014cisplatin
    PA449027cladribine
    PA164754863clofarabine
    PA449652floxuridine
    PA449655fludarabine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00197 antagonist Troglitazone Antineoplastic Agents;Hypoglycemic Agents;Vasodilator Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents
    No data
    Drugbank ID Action Drug Name Description
    DB00441 substrate Gemcitabine Antineoplastic Agents;Antiviral Agents;Radiation-Sensitizing Agents;Antimetabolites;Enzyme Inhibitors;Immunosuppressive Agents;Antimetabolites, Antineoplastic
    DB00811 substrate Rebetron (Schering-Plough) Antiviral Agents;Antimetabolites
    DB00987 substrate Cytarabine Antineoplastic Agents;Antiviral Agents;Antimetabolites;Immunosuppressive Agents;Antimetabolites, Antineoplastic
    DB01073 substrate Fludarabine Antineoplastic Agents;Antimetabolites;Immunosuppressive Agents;Antimetabolites, Antineoplastic
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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