Annotation Detail for R3HCC1
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C016403 |
2,4-dinitrotoluene |
2,4-dinitrotoluene affects the expression of R3HCC1 mRNA | affects expression | 21346803
|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene affects the expression of R3HCC1 mRNA | affects expression | 21346803
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of R3HCC1 mRNA | affects binding|decreases expression|increases activity | 19710929
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.64 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.22 | 16434500 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.63 | 19483382 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,4-dinitrotoluene |
3.11 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
3.11 | 16705839 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
3.06 | 6135515 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.15 | 19176532 |
| MESH:D003490 |
Cyanosis |
|
2,4-dinitrotoluene |
13.16 | 18551238 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
13.16 | 18551238 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.59 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,4-dinitrotoluene |
4.19 | 21346803 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
4.19 | 21346803 18551238 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.96 | 12083418 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.25 | 20131406 19236843 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.78 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.64 | 16221962 18467677 19772884 19176532 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.63 | 20558911 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.90 | 16306350 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,4-dinitrotoluene |
8.67 | 16705839 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
8.67 | 16705839 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
4.85 | 7678174 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
4.85 | 15890375 16377806 20007298 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.79 | 2876786 2876784 6135515 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
4.16 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.29 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.29 | 16411023 |
| MESH:D009336 |
Necrosis |
|
2,4-dinitrotoluene |
12.96 | 18551238 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
12.96 | 18551238 7678174 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.12 | 17405874 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.89 | 20558911 |
| MESH:D009784 |
Occupational Diseases |
|
2,4-dinitrotoluene |
10.41 | 12819281 16049721 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
10.41 | 16049721 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.56 | 19058328 |
| MESH:D012640 |
Seizures |
|
2,4-dinitrotoluene |
6.84 | 18551238 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
6.84 | 18551238 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,4-dinitrotoluene |
5.48 | 16049721 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
5.48 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,4-dinitrotoluene |
14.60 | 10091137 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
14.60 | 10091137 |
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