AutismKB 2.0

Annotation Detail for EP300


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Basic Information Top
Gene Symbol:EP300 ( KAT3B,p300 )
Gene Full Name: E1A binding protein p300
Band: 22q13.2
Quick LinksEntrez ID:2033; OMIM: 602700; Uniprot ID:EP300_HUMAN; ENSEMBL ID: ENSG00000100393; HGNC ID: 3373
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa04720Long-term potentiation
hsa04310Wnt signaling pathway
hsa05016Huntington's disease
hsa04630Jak-STAT signaling pathway
hsa04330Notch signaling pathway
hsa04350TGF-beta signaling pathway
hsa05211Renal cell carcinoma
hsa04110Cell cycle
hsa04520Adherens junction
hsa05215Prostate cancer
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200030HIF-2-alpha transcription factor network
200171Validated targets of C-MYC transcriptional repression
200070Signaling events mediated by HDAC Class I
200002Regulation of nuclear SMAD2/3 signaling
200027E2F transcription factor network
200130C-MYB transcription factor network
200013Notch signaling pathway
200020Signaling events mediated by HDAC Class III
200120FOXM1 transcription factor network
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
200091FoxO family signaling
200172HIF-1-alpha transcription factor network
200175p53 pathway
200077Glucocorticoid receptor regulatory network
200076Role of Calcineurin-dependent NFAT signaling in lymphocytes
200118AP-1 transcription factor network
200110IFN-gamma pathway
200116ATF-2 transcription factor network
200044Validated transcriptional targets of AP1 family members Fra1 and Fra2
200045Validated targets of C-MYC transcriptional activation
200101Direct p53 effectors
200102Regulation of Androgen receptor activity
200191Regulation of retinoblastoma protein
200196Notch-mediated HES/HEY network
200194FOXA1 transcription factor network
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00052TGF-beta signaling pathway
P00029Huntington disease
P00059p53 pathway
P00055Transcription regulation by bZIP transcription factor
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1712Yersinia infection
1818Systemic scleroderma
1831Prostate cancer
1832Congenital abnormality
1904Diabetes mellitus
1944Breast cancer
2031Endometrial cancer
2048Hepatoblastoma
2053Colon cancer
2157Scleroderma
2201Myeloproliferative disease
Desease Name
CANCER
breast cancer
No data
Desease Name
Colorectal cancer
Rubinstein-Taybi syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C477819 15-deoxyprostaglandin J2 15-deoxyprostaglandin J2 results in decreased localization of EP300 proteindecreases localization 15641079
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of EP300 mRNAaffects expression 21346803
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Doxorubicin results in decreased expression of EP300 protein]decreases expression|decreases reaction 15767673
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Doxorubicin results in increased degradation of EP300 protein]decreases reaction|increases degradation 15767673
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [MAP2K6 protein results in decreased expression of EP300 protein]decreases expression|decreases reaction 15767673
D013196 Dihydrotestosterone Dihydrotestosterone promotes the reaction [AR protein binds to EP300 protein]affects binding|increases reaction 18487222
D013196 Dihydrotestosterone Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 promoter]affects binding|increases reaction 18487222
D000643 Ammonium Chloride Ammonium Chloride affects the expression of EP300 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide promotes the reaction [EP300 protein binds to and results in increased acetylation of TP73 protein]affects binding|increases acetylation|increases reaction 15031205
C006632 arsenic trioxide arsenic trioxide results in increased activity of EP300 proteinincreases activity 15031205
C006632 arsenic trioxide arsenic trioxide results in increased expression of EP300 mRNAincreases expression 20458559
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein]affects localization|decreases reaction 17927689
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 mRNA]decreases expression|decreases reaction 17927689
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 protein]decreases expression|decreases reaction 17927689
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased degradation of EP300 protein]decreases reaction|increases degradation 15767673
D002166 Camptothecin Camptothecin results in decreased expression of EP300 mRNAdecreases expression 10344722
D002166 Camptothecin Camptothecin results in decreased expression of EP300 proteindecreases expression 10344722
D003474 Curcumin benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein]affects localization|decreases reaction 17927689
D003474 Curcumin benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 mRNA]decreases expression|decreases reaction 17927689
D003474 Curcumin benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 protein]decreases expression|decreases reaction 17927689
D003474 Curcumin Curcumin affects the localization of EP300 proteinaffects localization 17927689
D003474 Curcumin Curcumin results in decreased expression of EP300 mRNAdecreases expression 17927689
D003474 Curcumin Curcumin results in decreased expression of EP300 proteindecreases expression 17927689
C014347 decitabine decitabine affects the methylation of EP300 promoteraffects methylation 17965222
C014347 decitabine decitabine promotes the reaction [EP300 protein binds to TP53 protein]affects binding|increases reaction 17977830
D003907 Dexamethasone EP300 protein promotes the reaction [Dexamethasone results in increased expression of UCP3 mRNA]increases expression|increases reaction 17884810
D003907 Dexamethasone SIRT1 protein inhibits the reaction [EP300 protein promotes the reaction [Dexamethasone results in increased expression of UCP3 mRNA]]decreases reaction|increases expression|increases reaction 17884810
D002945 Cisplatin Cisplatin results in decreased expression of EP300 proteindecreases expression 17498666
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of EP300 proteindecreases expression 15019724
D002117 Calcitriol Calcitriol affects the localization of EP300 proteinaffects localization 15647825
D002117 Calcitriol Calcitriol promotes the reaction [EP300 protein binds to CYP24A1 promoter]affects binding|increases reaction 15647825
D002117 Calcitriol Calcitriol promotes the reaction [EP300 protein binds to SPP1 promoter]affects binding|increases reaction 15647825
D004317 Doxorubicin Doxorubicin results in decreased expression of EP300 mRNAdecreases expression 10344722
D004317 Doxorubicin Doxorubicin results in decreased expression of EP300 proteindecreases expression 17498666
10344722
D004317 Doxorubicin [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with Doxorubicin] results in increased expression of EP300 proteinaffects cotreatment|increases expression 15767673
D004317 Doxorubicin 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Doxorubicin results in decreased expression of EP300 protein]decreases expression|decreases reaction 15767673
D004317 Doxorubicin 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Doxorubicin results in increased degradation of EP300 protein]decreases reaction|increases degradation 15767673
D004317 Doxorubicin benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased degradation of EP300 protein]decreases reaction|increases degradation 15767673
D004317 Doxorubicin Doxorubicin results in decreased expression of EP300 proteindecreases expression 15767673
D004317 Doxorubicin Doxorubicin results in increased phosphorylation of and results in increased degradation of EP300 proteinincreases degradation|increases phosphorylation 15767673
D004317 Doxorubicin SB 203580 inhibits the reaction [Doxorubicin results in decreased expression of EP300 protein]decreases expression|decreases reaction 15767673
D004610 Ellagic Acid Ellagic Acid results in increased expression of EP300 mRNAincreases expression 12002526
D004958 Estradiol Estradiol promotes the reaction [EP300 protein binds to BRCA1 promoter]affects binding|increases reaction 16489025
D004958 Estradiol Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [EP300 protein binds to BRCA1 promoter]]affects binding|decreases reaction|increases reaction 16489025
D004958 Estradiol Estradiol promotes the reaction [[EP300 protein binds to VEGFA promoter] which results in increased expression of VEGFA mRNA]affects binding|increases expression|increases reaction 15774498
D019307 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with Doxorubicin] results in increased expression of EP300 proteinaffects cotreatment|increases expression 15767673
D019307 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in increased expression of EP300 proteinincreases expression 15767673
C051890 irinotecan irinotecan metabolite results in decreased expression of EP300 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of EP300 mRNAdecreases expression 15956246
C011890 kojic acid kojic acid results in increased expression of EP300 mRNAincreases expression 16595896
D009151 Mustard Gas Mustard Gas results in decreased expression of EP300 mRNAdecreases expression 18955075
C093973 PD 98059 PD 98059 inhibits the reaction [resveratrol promotes the reaction [PTGS2 protein binds to EP300 protein]]affects binding|decreases reaction|increases reaction 16928824
C093973 PD 98059 PD 98059 inhibits the reaction [Phenylephrine results in increased expression of EP300 mRNA]decreases reaction|increases expression 11705990
D010656 Phenylephrine EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]increases activity|increases expression|increases reaction 12724418
D010656 Phenylephrine EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]affects reaction|increases expression 11705990
D010656 Phenylephrine EP300 protein promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]increases expression|increases reaction 15593114
D010656 Phenylephrine EP300 protein results in increased susceptibility to Phenylephrineincreases response to substance 12477714
D010656 Phenylephrine MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of EP300 mRNA]increases expression|increases reaction 11705990
D010656 Phenylephrine PD 98059 inhibits the reaction [Phenylephrine results in increased expression of EP300 mRNA]decreases reaction|increases expression 11705990
D010656 Phenylephrine Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]affects binding|increases reaction 15220332
D010656 Phenylephrine [Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA proteinincreases activity|increases expression 12477714
D010656 Phenylephrine Phenylephrine results in increased expression of EP300 mRNAincreases expression 11705990
D010656 Phenylephrine Phenylephrine results in increased phosphorylation of and results in increased activity of EP300 proteinincreases activity|increases phosphorylation 15006641
D010656 Phenylephrine ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]affects binding|decreases reaction|increases reaction 15220332
C059514 resveratrol PD 98059 inhibits the reaction [resveratrol promotes the reaction [PTGS2 protein binds to EP300 protein]]affects binding|decreases reaction|increases reaction 16928824
C059514 resveratrol resveratrol promotes the reaction [PTGS2 protein binds to EP300 protein]affects binding|increases reaction 16928824
C059514 resveratrol resveratrol results in increased expression of EP300 mRNAincreases expression 12569576
12002526
C014794 retinol palmitate retinol palmitate promotes the reaction [EP300 protein binds to MMP9 protein]affects binding|increases reaction 17164434
C093642 SB 203580 SB 203580 inhibits the reaction [Doxorubicin results in decreased expression of EP300 protein]decreases expression|decreases reaction 15767673
C093642 SB 203580 SB 203580 inhibits the reaction [MAP2K6 protein results in decreased expression of EP300 protein]decreases expression|decreases reaction 15767673
C017947 sodium arsenite sodium arsenite inhibits the reaction [EP300 protein binds to IVL promoter]affects binding|decreases reaction 20006635
D018038 Sodium Selenite Sodium Selenite results in decreased expression of EP300 mRNAdecreases expression 10344722
D018038 Sodium Selenite Sodium Selenite results in decreased expression of EP300 proteindecreases expression 10344722
D013749 Tetrachlorodibenzodioxin EP300 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]affects reaction|increases expression 18842620
D013749 Tetrachlorodibenzodioxin EP300 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]affects reaction|increases expression 18842620
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [EP300 protein binds to BRCA1 promoter]]affects binding|decreases reaction|increases reaction 16489025
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [EP300 protein binds to CYP1A1 enhancer]affects binding|increases reaction 18842620
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [EP300 protein binds to CYP1A1 promoter]affects binding|increases reaction 18842620
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [EP300 protein binds to CYP1B1 enhancer]affects binding|increases reaction 18842620
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [EP300 protein binds to CYP1B1 promoter]affects binding|increases reaction 18842620
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [EP300 protein binds to PTGS2 promoter]affects binding|increases reaction 19056653
D014212 Tretinoin EP300 protein promotes the reaction [Tretinoin results in increased expression of ITGB2 mRNA]increases expression|increases reaction 16581781
D014212 Tretinoin [GABPA protein binds to EP300 protein] promotes the reaction [Tretinoin results in increased expression of ITGB2 mRNA]affects binding|increases expression|increases reaction 16581781
D014212 Tretinoin Tretinoin inhibits the reaction [EP300 protein binds to RETN promoter]affects binding|decreases reaction 15047602
C012589 trichostatin A trichostatin A affects the localization of EP300 proteinaffects localization 15647279
C012589 trichostatin A trichostatin A promotes the reaction [EP300 protein binds to TGFBR2 promoter]affects binding|increases reaction 15647279
C012589 trichostatin A trichostatin A promotes the reaction [[EP300 protein co-treated with EGR1 protein] results in increased expression of PTEN mRNA]affects cotreatment|increases expression|increases reaction 17330857
C012589 trichostatin A EP300 protein results in increased susceptibility to trichostatin Aincreases response to substance 12477714
D015032 Zinc Zinc affects the expression of EP300 proteinaffects expression 16636310
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5415322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2518287403
MESH:D000169 Acrodermatitis Zinc 5.0916889938 17190629 17202136
MESH:D058186 Acute Kidney Injury Cisplatin 7.9715814532 12690470 17670903
MESH:D058186 Acute Kidney Injury resveratrol 7.9716538975
MESH:D000230 Adenocarcinoma arsenic trioxide 9.5211798837 19825857
MESH:D000230 Adenocarcinoma Cisplatin 9.5211798837 17638652
MESH:D000230 Adenocarcinoma Doxorubicin 9.5217418594
MESH:D000230 Adenocarcinoma Estradiol 9.5211473722
MESH:D000236 Adenoma resveratrol 3.1415688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5917306315 16712894
MESH:D000419 Albuminuria Doxorubicin 4.2521441931
MESH:D019973 Alcohol-Related Disorders Curcumin 4.7717887948
MESH:D000505 Alopecia Tretinoin 3.3715955085
MESH:D000544 Alzheimer Disease Curcumin 6.3215590663
MESH:D000544 Alzheimer Disease resveratrol 6.3216162502 16183991
MESH:D000544 Alzheimer Disease Zinc 6.3216410023 17119284 16580781 16325427
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1815469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6811748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.6116916123
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.8517460149
MESH:D001169 Arthritis, Experimental Dexamethasone 11.2817659584
MESH:D001169 Arthritis, Experimental resveratrol 11.2817115116
MESH:D001169 Arthritis, Experimental Tretinoin 11.2816412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.4716807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4716292516
MESH:D001249 Asthma Mustard Gas 7.4110378619
MESH:D001249 Asthma Tretinoin 7.4116456186
MESH:D001249 Asthma Zinc 7.4117085522
MESH:D050197 Atherosclerosis Curcumin 6.3018704882
MESH:D050197 Atherosclerosis resveratrol 6.3016873680 17967414
MESH:D001327 Autoimmune Diseases Curcumin 4.1919761891
MESH:D001471 Barrett Esophagus Tretinoin 4.1116935849
MESH:D001768 Blister Mustard Gas 4.8519167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.7316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.7312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.7316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5715746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 11.0014601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 11.0014601052
MESH:D001919 Bradycardia Phenylephrine 4.2315306635
MESH:D001930 Brain Injuries Zinc 4.3917109824
MESH:D002545 Brain Ischemia Curcumin 9.2916770732
MESH:D002545 Brain Ischemia resveratrol 9.2917600658
MESH:D001932 Brain Neoplasms Curcumin 8.0717596214
MESH:D001932 Brain Neoplasms Doxorubicin 8.0717150277
MESH:D001943 Breast Neoplasms Calcitriol 6.6511237771
MESH:D001943 Breast Neoplasms Cisplatin 6.6519526202 18382427
MESH:D001943 Breast Neoplasms Curcumin 6.6519250217 18462866 18593918 16243823
MESH:D001943 Breast Neoplasms decitabine 6.6518320071 19208741
MESH:D001943 Breast Neoplasms Diethylstilbestrol 6.6517129689 15324884
MESH:D001943 Breast Neoplasms Doxorubicin 6.6515136595 16935488 16096432 15994142 18628466 18382427 16264153 15993339 18695136 16322301 15939500 15634643 19526202 18234424 16826403 15567936 17369602 16595493 11325840 15668708 17426702 16115903 17983394 15692762
MESH:D001943 Breast Neoplasms Estradiol 6.6517289903 12948864 17261762 18497071 19861407 17018787 14630087 16675129
MESH:D001943 Breast Neoplasms resveratrol 6.6516393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.6520435547
MESH:D001943 Breast Neoplasms Tretinoin 6.6516166294 16873071 16443354
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6617687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2816813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0411589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1516111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.4916051944
MESH:D002277 Carcinoma Curcumin 7.4818593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.4816835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8416168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 18.8116705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 18.8115553829 14691202 11135700 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 18.8117982673
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 18.8116924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 18.8116234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 18.8116924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 18.8119321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 18.8115276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 18.811917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.2816675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.4116685392 12023789
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.4118414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5619014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.0116201981 1485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8512490120
MESH:D002294 Carcinoma, Squamous Cell marker/mechanism 17965222
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 32.5311237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 32.536189445 17066447 18337622
MESH:D002294 Carcinoma, Squamous Cell Curcumin 32.5318462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 32.5319215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 32.536189445
MESH:D002294 Carcinoma, Squamous Cell resveratrol 32.5316227395
MESH:D002294 Carcinoma, Squamous Cell retinol palmitate 32.5315984520
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 32.5318572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 32.5316096774 16051514
MESH:D002294 Carcinoma, Squamous Cell Zinc 32.5316543248
MESH:D006332 Cardiomegaly Phenylephrine 6.3115728586 11754973 17124262 11179087 16170337 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3118670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.3316952015 16364871 16278810 17519947 17007740 17131338 15792986 16651473 17928571 17308081 16612575 16731534 17974986 17329180 17924179 15476868 16455267 16269455 16242529 16109756 15505089 15811867 17351982 17382496 18627295
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8416243910 17334414
MESH:D002318 Cardiovascular Diseases resveratrol 6.9415458977
MESH:D002318 Cardiovascular Diseases Zinc 6.9416936243
MESH:D002386 Cataract Tretinoin 2.9117460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.0418566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.0420056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9016835633
MESH:D002822 Choriocarcinoma Tretinoin 4.8416461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.4515894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3215668235 8697196 16354765 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.329407595
MESH:D003092 Colitis Curcumin 14.3416782535 16804969 18200517
MESH:D003092 Colitis resveratrol 14.3416474422
MESH:D003092 Colitis Tretinoin 14.3417035595
MESH:D003103 Coloboma Curcumin 4.2718809619
MESH:D003110 Colonic Neoplasms Curcumin 10.4316340194 19359593
MESH:D003110 Colonic Neoplasms decitabine 10.4317616700
MESH:D003110 Colonic Neoplasms Dexamethasone 10.4315824018
MESH:D003110 Colonic Neoplasms irinotecan 10.4317287894 17725105
MESH:D003110 Colonic Neoplasms resveratrol 10.4316338953
MESH:D015179 Colorectal Neoplasms marker/mechanism
MESH:D015179 Colorectal Neoplasms arsenic trioxide 7.9620501625
MESH:D015179 Colorectal Neoplasms Cisplatin 7.9615273666
MESH:D015179 Colorectal Neoplasms decitabine 7.9618981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 7.9618802399 18259882
MESH:D015179 Colorectal Neoplasms irinotecan 7.9618259882 15273666 16391804 16303861 17159606 17454858 18509181
MESH:D015179 Colorectal Neoplasms resveratrol 7.9616550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8017141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.5918497527
MESH:D003327 Coronary Disease resveratrol 3.5516507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 6.9310525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 6.9317728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.9310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.939142499 17551590 9211117 10589399 9125849 16925845 8800419 9664655 9224671 14991402
MESH:D019465 Craniofacial Abnormalities Zinc 6.9319302082
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.2612952375 16002989
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7118551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8115213294
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.1212438553
MESH:D003920 Diabetes Mellitus Sodium Selenite 8.5316285004
MESH:D003920 Diabetes Mellitus Zinc 8.5316479319
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5216873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.1318403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1317107852
MESH:D003928 Diabetic Nephropathies Curcumin 13.6018204486
MESH:D003928 Diabetic Nephropathies Estradiol 13.6019279558
MESH:D003928 Diabetic Nephropathies resveratrol 13.6016286809
MESH:D003967 Diarrhea Dexamethasone 3.417237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.1818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.1817416283
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 8.1815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.1820420201
MESH:D004362 Drug Toxicity Cisplatin 12.4619839026 12231392 15033597 12649298
MESH:D004362 Drug Toxicity Doxorubicin 12.4618602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.4611462148
MESH:D004381 Duodenal Ulcer Curcumin 3.7617351913
MESH:D004485 Eczema Dexamethasone 4.1612438553
MESH:D004487 Edema Dexamethasone 14.2319703484
MESH:D004487 Edema Mustard Gas 14.2311428631 11428647 9260866 11402378
MESH:D004487 Edema resveratrol 14.238985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.2312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.8915322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.8918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 8.4215138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 8.4217872969
MESH:D004701 Endocrine Gland Neoplasms decitabine 12.9719294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 12.9719294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.3816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.1416804899 15700306
MESH:D016889 Endometrial Neoplasms Doxorubicin 16.1417359293
MESH:D016889 Endometrial Neoplasms Estradiol 16.1411473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 16.1416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.769294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8418037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5417923197
MESH:D004890 Erythema Mustard Gas 4.859357497
MESH:D004938 Esophageal Neoplasms marker/mechanism 17965222
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.9112903497
MESH:D004938 Esophageal Neoplasms Cisplatin 6.9116481741 17638652 15464296 16785472 15173087
MESH:D004938 Esophageal Neoplasms Zinc 6.9116543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.0811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.089664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 7.1515073043
MESH:D005234 Fatty Liver Curcumin 7.1519297423
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.4716611131 16513791 16534752 16002989 15751030
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1511858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.2819069698
MESH:D005355 Fibrosis Curcumin 13.0718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.0720067830
MESH:D005355 Fibrosis Tretinoin 13.0717994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9716904648
MESH:D005756 Gastritis Zinc 4.4817241300
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.3918462866
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.7816452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.7816452187
MESH:D005909 Glioblastoma Curcumin 15.3517596214
MESH:D005909 Glioblastoma Doxorubicin 15.3517150277
MESH:D005909 Glioblastoma Tretinoin 15.3517312396
MESH:D005909 Glioblastoma trichostatin A 15.3518801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2810696789
MESH:D006130 Growth Disorders Zinc 3.7617217573
MESH:D006258 Head and Neck Neoplasms Cisplatin 27.4515102660 15464296
MESH:D006258 Head and Neck Neoplasms Curcumin 27.4518462866 18829502
MESH:D006258 Head and Neck Neoplasms decitabine 27.4519215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 27.4515692506
MESH:D006258 Head and Neck Neoplasms retinol palmitate 27.4515984520
MESH:D006258 Head and Neck Neoplasms Tretinoin 27.4516096774
MESH:D034381 Hearing Loss Cisplatin 4.0419898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8416084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.1715464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9910048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 5.9914991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 3.2714766674 16244371 16879835 16707910 16330681 16144979 17875725 12587719 16244372 17888722 18006777 18674790 16495754
MESH:D006333 Heart Failure Doxorubicin 6.8117481944
MESH:D006333 Heart Failure Zinc 6.8117162251
MESH:D006335 Heart Injuries Zinc 5.4517074742
MESH:D016481 Helicobacter Infections Zinc 4.2517241300
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6315692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0611000095
MESH:D006527 Hepatolenticular Degeneration Zinc 4.3917276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5916120746 15340226 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.7417701891
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.967520565
MESH:D006558 Herpes Genitalis Estradiol 4.7215709030
MESH:D006561 Herpes Simplex resveratrol 3.8716876885
MESH:D006689 Hodgkin Disease Cisplatin 10.8516170182 16200630
MESH:D006689 Hodgkin Disease Doxorubicin 10.8515147373 18501091 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 10.8512676792
MESH:D019584 Hot Flashes Estradiol 3.4417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7315340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Tretinoin 2.9716870215
MESH:D006937 Hypercholesterolemia Curcumin 8.4618704882
MESH:D006937 Hypercholesterolemia resveratrol 8.4617188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2616778211
MESH:D006949 Hyperlipidemias resveratrol 3.7416873680
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1314722030 12960047
MESH:D006973 Hypertension Dexamethasone 8.0117042910
MESH:D006973 Hypertension Phenylephrine 8.0112717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.0118670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.2818502941 12791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0317488730
MESH:D007021 Hypospadias Diethylstilbestrol 4.2816002989
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.3417600658
MESH:D007246 Infertility Diethylstilbestrol 4.0615036965
MESH:D007248 Infertility, Male decitabine 6.2217581917
MESH:D007248 Infertility, Male sodium arsenite 6.2212646999 15346721
MESH:D007249 Inflammation Curcumin 14.1417151092 18403477 16956363
MESH:D007249 Inflammation Dexamethasone 14.1411099482 8960868
MESH:D007249 Inflammation Mustard Gas 14.1417524151 8975870 11428620 9357497 9260866 11428631 11428647 16001271 11402378
MESH:D007249 Inflammation resveratrol 14.1416366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.1412200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0818596194 18200517
MESH:D007251 Influenza, Human resveratrol 4.2316624496
MESH:D007333 Insulin Resistance Estradiol 6.7616627594 16393666
MESH:D007333 Insulin Resistance Sodium Selenite 6.7614714311
MESH:D007410 Intestinal Diseases Tretinoin 3.4617994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.9510783313
MESH:D007511 Ischemia Zinc 4.3316584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.0116580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.0115992940 17551590
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.8215464296
MESH:D007674 Kidney Diseases Cisplatin 17.1715190930 12649298 19839026 18289764 12231392
MESH:D007674 Kidney Diseases Doxorubicin 17.1715369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 17.1715618244
MESH:D007674 Kidney Diseases sodium arsenite 17.1720008137
MESH:D007674 Kidney Diseases Zinc 17.1716960431
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.2616707910
MESH:D007676 Kidney Failure, Chronic Zinc 9.2616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.0216705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.0215003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 11.0215610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.4811231351
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7617184923
MESH:D007889 Leiomyoma Curcumin 4.2818555241
MESH:D007938 Leukemia arsenic trioxide 13.6915070760
MESH:D007938 Leukemia Curcumin 13.6918462866
MESH:D007938 Leukemia decitabine 13.6918980019 19235587
MESH:D007938 Leukemia Tretinoin 13.6917143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8416085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.8412560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.8416106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 10.6916972261
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 10.6916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 14.3919077051
MESH:D007951 Leukemia, Myeloid decitabine 14.3919117987 17236224 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 14.3916482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 8.2716467208 17050201 16968895 19850784 20471514
MESH:D015470 Leukemia, Myeloid, Acute decitabine 8.2718704418 19010910 19387464 18460780 18206229 17679729
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 8.2716294345 17596541 19850784
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 8.2718206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1518055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 11.6112712474 19075265 19035177 12679006 17649720 11161223 16891316 17869043 16823087 15622746 11468182 15748426 19642359 16331271 16112521 17217047 17712046 16966277 15213294 12018890 9834237 19225113 17107899 16330433 15336539
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 11.6116087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 11.6116823087 17368321 17712046 17217047 17107899 16331271 19075265 16140955 17361223 12679006 19035177 16935935 9834237 17301526 19642359 17506722 16766008 16891316 16788101 19029980 17339181 19225113 17294898 17649720 15748426
MESH:D015458 Leukemia, T-Cell arsenic trioxide 10.7316882451
MESH:D015458 Leukemia, T-Cell Curcumin 10.7316106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.099224671
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 8.1818705752 18006644 17355460
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 8.1816718785
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.1816595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.1814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.1812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.1816248980 18397230
MESH:D008107 Liver Diseases Curcumin 2.5416956363
MESH:D008113 Liver Neoplasms arsenic trioxide 12.9414682389
MESH:D008113 Liver Neoplasms Diethylstilbestrol 12.9415890375 16712894
MESH:D008113 Liver Neoplasms resveratrol 12.9419812893 19321006 19073162 20405173
MESH:D008113 Liver Neoplasms sodium arsenite 12.9416712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.9416984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 12.5720377131
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 12.5716842330 17085340
MESH:D008114 Liver Neoplasms, Experimental kojic acid 12.5718544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.5712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1215213294
MESH:D008171 Lung Diseases Mustard Gas 6.8518702808 18161513
MESH:D008171 Lung Diseases sodium arsenite 6.8519095001
MESH:D008175 Lung Neoplasms arsenic trioxide 12.2411798837 19825857
MESH:D008175 Lung Neoplasms Cisplatin 12.246189445 17225452 11798837
MESH:D008175 Lung Neoplasms Curcumin 12.2416243823 18462866 19359593
MESH:D008175 Lung Neoplasms Dexamethasone 12.2415824018 11195469
MESH:D008175 Lung Neoplasms Doxorubicin 12.2417418594 6189445
MESH:D008175 Lung Neoplasms Mustard Gas 12.243148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 12.2419931552 16712894 15276417 17306315 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.2411884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8415166399
MESH:D008223 Lymphoma Curcumin 16.1118462866
MESH:D008223 Lymphoma decitabine 16.1119470736
MESH:D008223 Lymphoma Diethylstilbestrol 16.1115700306
MESH:D008223 Lymphoma Doxorubicin 16.1116098063
MESH:D016393 Lymphoma, B-Cell resveratrol 9.3217088997
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 9.3214737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.0517654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 8.0514749477
MESH:D016399 Lymphoma, T-Cell Curcumin 10.5516173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 10.5515621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2016002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.9415688416
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 12.6915458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.6911807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 12.698985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Zinc 12.6912773700
MESH:D020149 Manganese Poisoning Estradiol 4.1719453300
MESH:D008527 Medulloblastoma Tretinoin 2.6617453147
MESH:D008545 Melanoma Cisplatin 17.3912883367 16809738 18332650 12374674 18176117 18505091 11135225 16432458 15577323 17761969 12393984 17023156 16248763
MESH:D008545 Melanoma Curcumin 17.3917885582 18462866
MESH:D008545 Melanoma decitabine 17.3916505122 17785578
MESH:D008545 Melanoma Doxorubicin 17.3916827129
MESH:D008545 Melanoma resveratrol 17.3917992120
MESH:D008545 Melanoma sodium arsenite 17.3919082730 16487513
MESH:D008545 Melanoma Tretinoin 17.3916752155
MESH:D008545 Melanoma trichostatin A 17.3916505122
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.4615990972
MESH:D008569 Memory Disorders Curcumin 3.8617263510
MESH:D008591 Meningomyelocele Tretinoin 4.1216940565
MESH:D008654 Mesothelioma Cisplatin 6.0317638057
MESH:D008654 Mesothelioma Doxorubicin 6.0317638057
MESH:D008659 Metabolic Diseases resveratrol 4.1017112576
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2215792986
MESH:D052016 Mucositis Doxorubicin 11.3817415656
MESH:D052016 Mucositis irinotecan 11.3817159606
MESH:D009101 Multiple Myeloma arsenic trioxide 25.4119417148 14977855 11468182 19549372 15949261
MESH:D009101 Multiple Myeloma Curcumin 25.4119372569
MESH:D009101 Multiple Myeloma decitabine 25.4118172295
MESH:D009101 Multiple Myeloma Dexamethasone 25.4115867202 16118317 15744524
MESH:D009101 Multiple Myeloma resveratrol 25.4117935668 16490592 14749477 17049120 16267019 17164350
MESH:D009101 Multiple Myeloma trichostatin A 25.4118172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 11.3817962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 11.3817962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 16.1316882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 16.1318608210 19157545 19010910 16882708
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 16.139809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 16.1317596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.5919429709 15857846
MESH:D009203 Myocardial Infarction resveratrol 5.5916525036 16456233 17188708 17125593 16317513 17015251
MESH:D017202 Myocardial Ischemia resveratrol 8.2017125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.2012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0516810080
MESH:D009205 Myocarditis resveratrol 4.4517322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.5518551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 9.3416624393
MESH:D009361 Neoplasm Invasiveness Curcumin 9.3418495463
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.6818259882
MESH:D009362 Neoplasm Metastasis irinotecan 5.6818259882
MESH:D009369 Neoplasms Cisplatin 14.0816773208
MESH:D009369 Neoplasms decitabine 14.0817925555 19116145 19470736
MESH:D009369 Neoplasms Diethylstilbestrol 14.0815313581
MESH:D009369 Neoplasms sodium arsenite 14.0811559025
MESH:D009369 Neoplasms Tretinoin 14.0816594593 16946489
MESH:D009374 Neoplasms, Experimental resveratrol 8.228985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.2220056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.2212497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4217289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.1815464296
MESH:D009401 Nephrosis Doxorubicin 4.4616899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.7416889571 15640375
MESH:D009421 Nervous System Malformations Diethylstilbestrol 21.0111399458
MESH:D009421 Nervous System Malformations Estradiol 21.0111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.0114600291
MESH:D009421 Nervous System Malformations Tretinoin 21.019125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.3118462866
MESH:D009436 Neural Tube Defects arsenic trioxide 10.9810525206
MESH:D009436 Neural Tube Defects sodium arsenite 10.9812854658
MESH:D009436 Neural Tube Defects Tretinoin 10.989142499
MESH:D009447 Neuroblastoma Cisplatin 10.598761367
MESH:D009447 Neuroblastoma Doxorubicin 10.5915555623
MESH:D009447 Neuroblastoma irinotecan 10.598761367
MESH:D019636 Neurodegenerative Diseases resveratrol 3.5617652729
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.438761367
MESH:D017599 Neuroectodermal Tumors irinotecan 10.438761367
MESH:D020078 Neurogenic Inflammation resveratrol 4.1117929310
MESH:D009503 Neutropenia Mustard Gas 3.697688884 16761898
MESH:D009765 Obesity Curcumin 2.6719297423
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.1616049721 12819281
MESH:D010024 Osteoporosis Curcumin 3.2818719352
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.9717513867
MESH:D012516 Osteosarcoma Doxorubicin 3.8715930896
MESH:D010033 Otitis Media retinol palmitate 6.5617303254
MESH:D010051 Ovarian Neoplasms arsenic trioxide 25.3416624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Cisplatin 25.3419769630 17225452 6897625 15464296
MESH:D010051 Ovarian Neoplasms Curcumin 25.3419020741 18462866
MESH:D010051 Ovarian Neoplasms decitabine 25.3419259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 25.3419401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 25.3417306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 25.3416936753
MESH:D010051 Ovarian Neoplasms trichostatin A 25.3419331143
MESH:D010146 Pain Tretinoin 2.6616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 19.0015580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 19.0019003803
MESH:D010190 Pancreatic Neoplasms Curcumin 19.0017440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms decitabine 19.0019294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 19.0015976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 19.0019294695
MESH:D010235 Paraganglioma arsenic trioxide 3.8819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9312520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.0115464296
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8417983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8514722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3716977796 15687265
MESH:D010997 Pleural Neoplasms Cisplatin 12.8817638057
MESH:D010997 Pleural Neoplasms Doxorubicin 12.8817638057
MESH:D011041 Poisoning Mustard Gas 3.5115727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2618163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3721297632
MESH:D011225 Pre-Eclampsia Zinc 3.9417114810
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 14.5117184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 14.5116679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.5111222880 11399792 11118676 11896295
MESH:D055728 Primary Myelofibrosis decitabine 11.4117616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.4117616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.4715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6120887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 4.0819131511
MESH:D011471 Prostatic Neoplasms Calcitriol 4.0812479363 16289102 18247401 15754350 16644109
MESH:D011471 Prostatic Neoplasms Curcumin 4.0818769126 12497104 18226269 18156803 10851300 15129424 11398177
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 4.0815846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 4.0815897917 15749863 18437689 16868541 16729912 16888761
MESH:D011471 Prostatic Neoplasms Estradiol 4.0816740699
MESH:D011471 Prostatic Neoplasms resveratrol 4.0817718901 17804756 15767336 17675339 16731767 17636462
MESH:D011471 Prostatic Neoplasms sodium arsenite 4.0816039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 4.0818760546
MESH:D011471 Prostatic Neoplasms trichostatin A 4.0819789329 18798265
MESH:D011471 Prostatic Neoplasms Zinc 4.0812429649 16700911 16517595 16606632
MESH:D011507 Proteinuria Tretinoin 3.3216636307
MESH:D011537 Pruritus Mustard Gas 3.7818058305
MESH:D011625 Pterygium Tretinoin 4.4816723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.2619168576
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8117894541 17620002 17266442 17720292 10334151
MESH:D051437 Renal Insufficiency Cisplatin 9.3715464296
MESH:D051437 Renal Insufficiency Doxorubicin 9.3717922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.2716325855
MESH:D015427 Reperfusion Injury resveratrol 3.1216317513 16314181 17058453 17520802 15827377
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 8.3610666014 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 8.3618379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5418990726
MESH:D012162 Retinal Degeneration Zinc 3.9016584753
MESH:D012208 Rhabdomyosarcoma decitabine 9.9919155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.9916116481 16283617
MESH:D012415 Rubinstein-Taybi Syndrome marker/mechanism
MESH:D012509 Sarcoma Curcumin 8.6818462866
MESH:D012509 Sarcoma Doxorubicin 8.6816767912 17203757 15625365 18313854 17710206 15675481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 15.5716646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 15.5714601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 15.5714601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4817846226
MESH:D012640 Seizures 2,4-dinitrotoluene 2.3318551238
MESH:D018805 Sepsis Curcumin 3.8218389075
MESH:D012852 Sinusitis Phenylephrine 4.397327846
MESH:D012871 Skin Diseases Mustard Gas 2.6312880345 16961503 15451306
MESH:D012878 Skin Neoplasms Doxorubicin 16.3515692506
MESH:D012878 Skin Neoplasms resveratrol 16.3515837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 16.3518572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.3516192470
MESH:D012878 Skin Neoplasms Tretinoin 16.3516467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.0315464296
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2616767912 17203757 15625365
MESH:D013088 Spermatocele Diethylstilbestrol 4.4016709447 16002989
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5612854658
MESH:D013272 Stomach Diseases Dexamethasone 4.0115472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 6.0417007042
MESH:D013274 Stomach Neoplasms Cisplatin 6.0415958060 17522103 18396642
MESH:D013274 Stomach Neoplasms decitabine 6.0419037991
MESH:D013274 Stomach Neoplasms irinotecan 6.0415723263
MESH:D013274 Stomach Neoplasms Tretinoin 6.0417261132
MESH:D013276 Stomach Ulcer Curcumin 6.6319188055 16631530
MESH:D013276 Stomach Ulcer Dexamethasone 6.6315138204
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2116321402
MESH:D024801 Tauopathies Camptothecin 5.3116930453
MESH:D013736 Testicular Neoplasms Cisplatin 4.3415464296 17225452
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5912697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 15.2219014326
MESH:D013964 Thyroid Neoplasms decitabine 15.2217967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 15.2217909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 15.2217045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.3719048282
MESH:D014062 Tongue Neoplasms resveratrol 15.0816227395
MESH:D014062 Tongue Neoplasms Tretinoin 15.0816051514
MESH:D014062 Tongue Neoplasms Zinc 15.0816543248
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6515213294
MESH:D014376 Tuberculosis Tretinoin 3.0416040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 26.3316049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 26.3312845720 11780464 20435036 12973940
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 26.3315464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms Curcumin 26.3318593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 26.3319087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 26.3317306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 26.3317653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 26.3317306315 11723127 16712894 16452187
MESH:D014565 Urogenital Neoplasms Curcumin 4.9518462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0010091137
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 26.7916803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 26.7916175088
MESH:D002583 Uterine Cervical Neoplasms resveratrol 26.7917473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 26.7911813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 26.7916129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.8514652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.8016690809 15809267
MESH:D014594 Uterine Neoplasms resveratrol 8.8017044934
MESH:D014604 Uveal Neoplasms decitabine 11.7717785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.7716752155
MESH:D014605 Uveitis Dexamethasone 4.501336536
MESH:D014625 Vaginal Neoplasms Cisplatin 10.0715577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 10.0716002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.1117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2812125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 9.3317334414 16364871 17678736 17638931
MESH:D018487 Ventricular Dysfunction, Left resveratrol 9.3317488730
MESH:D014820 Vitiligo Tretinoin 3.7616761959
MESH:D014839 Vomiting Cisplatin 4.4011897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9315886252
MESH:D009396 Wilms Tumor Tretinoin 3.7116287080
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:04110 Cell cycle
REACT:15380 Diabetes pathways
KEGG:05016 Huntington's disease
KEGG:04630 Jak-STAT signaling pathway
KEGG:04720 Long-term potentiation
KEGG:04916 Melanogenesis
KEGG:04330 Notch signaling pathway
KEGG:05200 Pathways in cancer
KEGG:05215 Prostate cancer
KEGG:05211 Renal cell carcinoma
REACT:6900 Signaling in Immune system
KEGG:04350 TGF-beta signaling pathway
KEGG:05152 Tuberculosis
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27807
    • Releated gene ID Related gene Name
    PA26866CREBBP
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA151958596curcumin
    PA164743471adenosine triphosphate
    PA449773glucose
    PA164778686pyruvic acid
    PA449247dexamethasone
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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