AutismKB 2.0

Annotation Detail for AK2


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Basic Information Top
Gene Symbol:AK2 ( ADK2 )
Gene Full Name: adenylate kinase 2
Band: 1p35.1
Quick LinksEntrez ID:204; OMIM: 103020; Uniprot ID:KAD2_HUMAN; ENSEMBL ID: ENSG00000004455; HGNC ID: 362
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00230Purine metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of nucleotides
No data
Pathway IDPathway Name
P02738De novo purine biosynthesis
Pathway IDPathway Name
500233Synthesis and interconversion of nucleotide di- and triphosphates
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of AK2 mRNAdecreases expression 12958071
C041594 4-nonylphenol 4-nonylphenol affects the expression of AK2 mRNAaffects expression 15792627
D000082 Acetaminophen Acetaminophen affects the expression of AK2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AK2 mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of AK2 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of AK2 mRNAincreases expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of AK2 mRNAaffects expression 12734012
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of AK2 mRNAdecreases expression 16239168
C099555 CD 437 CD 437 results in decreased expression of AK2 mRNAdecreases expression 12958071
D016572 Cyclosporine Cyclosporine results in decreased expression of AK2 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of AK2 mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of AK2 mRNAaffects expression 17555576
C051890 irinotecan AK2 protein results in increased susceptibility to irinotecanincreases response to substance 16734730
C041786 palm oil palm oil results in decreased expression of AK2 mRNAdecreases expression 18042831
C076994 perfluorooctane sulfonic acid perfluorooctane sulfonic acid results in decreased expression of AK2 proteindecreases expression 19474218
D010634 Phenobarbital Phenobarbital results in increased expression of AK2 mRNAincreases expression 19270015
D012643 Selenium Selenium results in increased expression of AK2 mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of AK2 mRNAaffects expression 17555576
C066340 tolcapone tolcapone binds to AK2 proteinaffects binding 19783845
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5514745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.436195326
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8114692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 3.9617620307
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.2911080934
MESH:D000544 Alzheimer Disease tolcapone 3.2720150427
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001161 Arteriosclerosis Dietary Fats 9.8615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.8611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001943 Breast Neoplasms Dietary Fats 2.1820435547
MESH:D001943 Breast Neoplasms Tamoxifen 2.1819189210 21152245 19221464 17261762 17049068 19288272 18815881 18997820 18351453 18821012 18855134 20065188 15565566 20859285 19487384 19066611 15668708 19410462 19115204 18984771 17440819 18425577 19084267 20005174 19011961 17242785 19189212 20390343 16873071 19289846 17893378 16818667 21138602 19200415 20544844 19059307 18629630 16273361 16202921 19142967 19155303 11161223 19244106 20135344 19103187
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7716192424 18705752 15721981 16097048 16227642 16011737 15673190 16124888 16050911 3786805 15700767 10355542
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4919066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.533084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.5318788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.5320935162 17173139 6705139 20007298 1701930
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.5316924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6017572228
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5112371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.244080065
MESH:D002779 Cholestasis Cyclosporine 7.7219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.7216919318 17110522 16105132 15861022 17681005 11677210 17333356
MESH:D003092 Colitis Selenium 3.7717936198
MESH:D003110 Colonic Neoplasms irinotecan 2.5917725105 17287894
MESH:D015179 Colorectal Neoplasms irinotecan 2.3616303861 18259882 17159606 16391804 15273666 17454858 18509181
MESH:D003638 Deafness marker/mechanism 19043416
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3519031437
MESH:D003866 Depressive Disorder tolcapone 4.2911224284 7768276
MESH:D003865 Depressive Disorder, Major tolcapone 4.8810440460
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9919164858 19739265 19923254 11743745 17562736 17906064 12594235 15968718 16485898 11461765 16227642 19085960 16081117 10915739 11834606 12705907 16109766 11287661 16393943 16781746 12958197 18071297 2444490 19416960 14986274 14725611 17522070 18713872 11421492 11739529 19370779 16177239 14550746 12540782 15619225 12153990 12392966 19420014 11529661 10774834 10663392
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.9919336974 6623471 16177239 7120509 7440962 10092053 9327722 15998439 4309450 3786805 15968718 15027814 16227642 3732212 11566570 6884620 17522070 2869522 19085960 21278145 10915739 7179309
MESH:D056486 Drug-Induced Liver Injury Selenium 8.9915131321
MESH:D056486 Drug-Induced Liver Injury tolcapone 8.9919783845 16604736
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.4011455177
MESH:D050171 Dyslipidemias Dietary Fats 3.4418367378
MESH:D004421 Dystonia Phenobarbital 3.991851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.8919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0317893378 19155303 20544844 16202921
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.093659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.8711558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.8820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.526401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.247750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.013659116
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 5.9519578428
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.4717595544 16045604 19224547 12795759 61145 15959796 12631006 16239168
MESH:D005234 Fatty Liver Cyclosporine 24.4719224547
MESH:D005234 Fatty Liver Dietary Fats 24.4717967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.4715345470
MESH:D005234 Fatty Liver Tamoxifen 24.4714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2216709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 14.7218705752
MESH:D005355 Fibrosis Cyclosporine 14.7212168785 12639820
MESH:D005355 Fibrosis Dietary Fats 14.7218296743
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D005909 Glioblastoma perfluorooctane sulfonic acid 4.2517162496
MESH:D006333 Heart Failure Selenium 3.0617162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5819110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 3.4716109766
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5216899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5721332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6021332399
MESH:D006973 Hypertension Cyclosporine 2.0910903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0715338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4717937319
MESH:D007249 Inflammation Dietary Fats 5.0620412841
MESH:D007249 Inflammation Tamoxifen 5.0619457130
MESH:D007251 Influenza, Human Selenium 4.2016624496
MESH:D007333 Insulin Resistance Dietary Fats 3.0911836018 18457598
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007674 Kidney Diseases Acetaminophen 5.7515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.758314463 10903974 18776723
MESH:D007676 Kidney Failure, Chronic Selenium 3.8716518626
MESH:D007680 Kidney Neoplasms Cyclosporine 7.2412371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.2418625569
MESH:D008064 Lipidoses Tamoxifen 3.1417567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.9611903743 17157831 16943688 16221502 17334410 16239168 17174718 21278145 11408273
MESH:D008103 Liver Cirrhosis Dietary Fats 10.9618296743
MESH:D008103 Liver Cirrhosis Phenobarbital 10.9621047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.4615893842 12666154 18205269 17944888 15338365 14716833 17805973 18705752 15673190 17900296 18279442 17823541 16027843 16011737 18187930 16116963 18156304 16033810 18412020 16097048 18429990 15052691 11481614 14716496 10355542 18481824 18210741 15959796 12898905 18166357 15876570 18317297 16248980 18395095 12958196 14748882 12667390 15057751 12445421 18263696 20821823 14724832 12586293 17976157 18339082 18420326 16192424 18472332 13678700 18277467 17721639 12609069 15730626 17565644 18395914 17869086 12632514 17481882 15123356 17922224 17525996 18054572 15650968 16638106 12741479 15931870 15996030 16136751 17640975 12445418 18418968 18376398 12632512 18251166 17557913 17714472 15362042 16015684 17631135 15370692 17766677 14512876 12546737 18472094 17698563 12389079 12649538 18006644 17708605 14620537 15925388 17761835 15818738
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.4618564211
MESH:D008107 Liver Diseases Acetaminophen 6.4512587719 12969438 11587558 16611625 19460945 19014921 16610002 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.4517285989 15720792 15830285 16964402 16246199
MESH:D008107 Liver Diseases Phenobarbital 6.4519363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.3517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.3516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.4219294768
MESH:D008113 Liver Neoplasms Phenobarbital 7.4219482888 19812893 21047994 15975961 19073162 8742319
MESH:D008113 Liver Neoplasms Tamoxifen 7.4216684651
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.9312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 5.9317172636 6150874 1399818 2563599 18308698
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7519428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.0015318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.0011731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.5519453300
MESH:D008545 Melanoma Tamoxifen 1.8819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008654 Mesothelioma Selenium 2.7815107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D052016 Mucositis irinotecan 5.0017159606
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4717484760
MESH:D009362 Neoplasm Metastasis irinotecan 5.9218259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.9219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5119410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0019189210 19200415 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2719348381 18481113
MESH:D009447 Neuroblastoma irinotecan 3.478761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.728761367
MESH:D009765 Obesity Dietary Fats 2.2817217161 21332399 16723640 19632207 18674790 18457598 11836018 20518802 20132043
MESH:D010018 Osteomalacia Phenobarbital 4.3617016548
MESH:D010051 Ovarian Neoplasms CD 437 3.3117474084
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.4816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010300 Parkinson Disease tolcapone 3.599333106 1977408 18328768 11746615 17089403 8635184 20334432 19578428 7566641 9708959 11586115 11432539 19783845 16758261 8739811 9305320 9754991 10651109 11793426 20216409 9591521
MESH:D010954 Plasmacytoma Selenium 4.8915087411
MESH:D011230 Precancerous Conditions Cyclosporine 8.9112371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.912563599
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1615067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3015861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.5012752131
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:C538361 Reticular dysgenesis marker/mechanism
MESH:D012640 Seizures Phenobarbital 2.6811442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.816407741
MESH:D016511 Severe Combined Immunodeficiency marker/mechanism 19043416 19043417
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.688532709
MESH:D013088 Spermatocele Ethinyl Estradiol 11.5616709447
MESH:D013088 Spermatocele Tamoxifen 11.5616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0319457130
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.041399818
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 5.9519578428
MESH:D001749 Urinary Bladder Neoplasms CD 437 5.4116720286
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.4117572228 16712894 8653321
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5215869587 14671159
MESH:D014820 Vitiligo tolcapone 5.1710573327
MESH:D015430 Weight Gain Dietary Fats 3.7216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:1698 Metabolism of nucleotides
KEGG:00230 Purine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24656
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443796Coronary Artery Disease
    PA445019Myocardial Infarction
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01717 - Bis(Adenosine)-5'-Pentaphosphate
    DB03366 - Imidazole Enzyme Inhibitors
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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