AutismKB 2.0

Annotation Detail for EPHA1


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Basic Information Top
Gene Symbol:EPHA1 ( EPH,EPHT,EPHT1,MGC163163 )
Gene Full Name: EPH receptor A1
Band: 7q34-q35
Quick LinksEntrez ID:2041; OMIM: 179610; Uniprot ID:EPHA1_HUMAN; ENSEMBL ID: ENSG00000146904; HGNC ID: 3385
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1779Cervical cancer
1859Ovarian cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of EPHA1 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of EPHA1 mRNAaffects expression 17562736
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of EPHA1 mRNAaffects cotreatment|increases expression 18585445
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of EPHA1 mRNAaffects cotreatment|increases expression 18585445
C004742 daidzein [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of EPHA1 mRNAaffects cotreatment|increases expression 16963248
C014347 decitabine decitabine results in decreased methylation of EPHA1 promoterdecreases methylation 19277044
C014347 decitabine decitabine results in increased expression of EPHA1 mRNAincreases expression 19277044
C014347 decitabine decitabine results in increased expression of EPHA1 proteinincreases expression 19277044
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of EPHA1 mRNAincreases expression 17317680
D019833 Genistein [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of EPHA1 mRNAaffects cotreatment|increases expression 16963248
C086566 glycitein [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of EPHA1 mRNAaffects cotreatment|increases expression 16963248
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of EPHA1 mRNAincreases expression 12634122
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of EPHA1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of EPHA1 mRNAdecreases expression 18445702
C017947 sodium arsenite sodium arsenite results in increased expression of EPHA1 mRNAincreases expression 12760830
D014415 Tunicamycin Tunicamycin results in increased expression of EPHA1 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma daidzein 5.0111473722
MESH:D000230 Adenocarcinoma Genistein 5.0111473722
MESH:D000236 Adenoma 2-Acetylaminofluorene 7.1510737359
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.153712494
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.146705139
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6016434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0416712894 17306315
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.3411874814
MESH:D000544 Alzheimer Disease marker/mechanism 21460841 21460840
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.151440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2319483382
MESH:D001943 Breast Neoplasms decitabine 2.3919208741 18320071
MESH:D001943 Breast Neoplasms Genistein 2.3916541309 17200150 16873071
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 9.023084413 10737359 17761372 3581430 6705139
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.023581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.023084413
MESH:D006528 Carcinoma, Hepatocellular Genistein 9.0216924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 9.0217306315 15276417 16507464
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.8719215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.8718572023
MESH:D002318 Cardiovascular Diseases daidzein 7.9816332659
MESH:D002318 Cardiovascular Diseases Genistein 7.9816332659
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.707505956
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 11.702727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.7020056578 19524636
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.049022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.0419176532
MESH:D003110 Colonic Neoplasms decitabine 3.9317616700
MESH:D003110 Colonic Neoplasms Genistein 3.9317182828
MESH:D015179 Colorectal Neoplasms marker/mechanism 19277044
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.902524372 12868966 11906362 8156756 14531868 18759878 8970840 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.583621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 5.0416647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 5.0416647724
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.7816192314 8291058 7440962 9328219 18692083 9022650 18289764 11289319 9653073 18648102 1440618 6679447 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7816485898 12705907 19370779 2444490 19420014 16177239 19164858 11421492 17562736 16781746 10663392 16109766 16393943 16081117 12392966 16227642 12594235 11287661 11529661 15968718 12153990 12958197 18713872 17522070 10774834 17906064 19923254 19085960 12540782 10915739 11461765 11834606 19416960 14725611 11739529 19739265 11743745 15619225 14550746 14986274 18071297
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004487 Edema pirinixic acid 2.5612083418
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2519294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.7116402032
MESH:D016889 Endometrial Neoplasms daidzein 8.1711473722
MESH:D016889 Endometrial Neoplasms Genistein 8.1711473722
MESH:D007172 Erectile Dysfunction daidzein 5.1114972507
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005234 Fatty Liver pirinixic acid 2.8519236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8016452187
MESH:D005909 Glioblastoma Genistein 3.3116598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006258 Head and Neck Neoplasms decitabine 3.5419215824
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.456705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.496705139
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006529 Hepatomegaly pirinixic acid 3.1016221962 19772884 18467677 19176532
MESH:D006689 Hodgkin Disease sodium arsenite 3.2212676792
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006973 Hypertension daidzein 3.7017169123
MESH:D007248 Infertility, Male Atrazine 11.7112948887
MESH:D007248 Infertility, Male decitabine 11.7117581917
MESH:D007248 Infertility, Male sodium arsenite 11.7115346721 12646999
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.158074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 6.1115629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.1120008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.036582329
MESH:D007938 Leukemia decitabine 6.6518980019 19235587
MESH:D007938 Leukemia Genistein 6.6517468513 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.0819117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3918206229 19010910 19387464 17679729 18704418 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6018055864
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.249327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.4617823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4615474484
MESH:D008107 Liver Diseases Acetaminophen 1.6512587719 12969438 16610002 19784758 11587558 16611625 19014921 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 7.7111376686 16273603 14678523 10672840 18001218 10737359
MESH:D008113 Liver Neoplasms pirinixic acid 7.7120007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 7.7116712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 6.41534488 6150874 1399818
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.41598648 6587162 3712494 1399818
MESH:D008171 Lung Diseases sodium arsenite 3.2219095001
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 2.8411376686
MESH:D008175 Lung Neoplasms sodium arsenite 2.8415276417 17077188 19931552 17306315 16712894
MESH:D008223 Lymphoma decitabine 3.4719470736
MESH:D008325 Mammary Neoplasms, Experimental Genistein 2.9914578162 12929590
MESH:D008545 Melanoma decitabine 3.4916505122 17785578
MESH:D008545 Melanoma sodium arsenite 3.4916487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma Atrazine 3.561916698
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 6.0117671175
MESH:D009101 Multiple Myeloma decitabine 3.4018172295
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4319157545 16882708 18608210 19010910
MESH:D009203 Myocardial Infarction Genistein 5.7817141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.7819151258
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.6017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6016411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.503581430
MESH:D009369 Neoplasms decitabine 8.5017925555 19116145 19470736
MESH:D009369 Neoplasms pirinixic acid 8.5017405874
MESH:D009369 Neoplasms sodium arsenite 8.5011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7720056578
MESH:D009421 Nervous System Malformations Genistein 4.1316427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.436679447
MESH:D009436 Neural Tube Defects sodium arsenite 7.4312854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.506482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010024 Osteoporosis Genistein 3.3019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1716169203
MESH:D010051 Ovarian Neoplasms decitabine 8.1119331143 19259094
MESH:D010051 Ovarian Neoplasms Genistein 8.1119005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.1115276417 17306315
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.7919294695
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010300 Parkinson Disease Atrazine 3.3017218051
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D055728 Primary Myelofibrosis decitabine 4.8317616702
MESH:D011471 Prostatic Neoplasms Genistein 3.3516925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3516039940
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D012135 Respiratory Sounds Atrazine 4.6211874814
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.4919155313
MESH:D012878 Skin Neoplasms sodium arsenite 2.7318572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8612854658
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.456582329 3712494 1399818 6587162 7505956
MESH:D013964 Thyroid Neoplasms decitabine 7.4517967635
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 12.241399818 15867355 15289314
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.248074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 12.2419087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.2416452187 16712894 11723127 17306315
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.8411813266
MESH:D014604 Uveal Neoplasms decitabine 5.0517785578
MESH:D014652 Vascular Diseases sodium arsenite 4.5417056641
Pathway ID Pathway Name
KEGG:04360 Axon guidance
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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