AutismKB 2.0

Annotation Detail for EPHA3


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Basic Information Top
Gene Symbol:EPHA3 ( EK4,ETK,ETK1,HEK,HEK4,TYRO4 )
Gene Full Name: EPH receptor A3
Band: 3p11.1
Quick LinksEntrez ID:2042; OMIM: 179611; Uniprot ID:EPHA3_HUMAN; ENSEMBL ID: ENSG00000044524; HGNC ID: 3387
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
No data
Pathway IDPathway Name
200121EPHA forward signaling
Pathway IDPathway Name
P00005Angiogenesis
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015081 2-Naphthylamine 2-Naphthylamine results in decreased expression of EPHA3 mRNAdecreases expression 18247414
D000643 Ammonium Chloride Ammonium Chloride affects the expression of EPHA3 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of EPHA3 mRNAdecreases expression 18247414
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of EPHA3 mRNAaffects expression 17484886
D009538 Nicotine Nicotine results in decreased expression of EPHA3 mRNAdecreases expression 18247414
D010126 Ozone Ozone results in decreased expression of EPHA3 mRNAdecreases expression 16330353
C116926 rofecoxib rofecoxib results in decreased expression of EPHA3 mRNAdecreases expression 17070997
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D000544 Alzheimer Disease Nicotine 4.8216627626
MESH:D000544 Alzheimer Disease Ozone 4.8215513908
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001169 Arthritis, Experimental rofecoxib 4.5016690336
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6115570426
MESH:D001249 Asthma Ozone 2.7016373670 17854713
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0017474063 20146248
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9017626835 18417511 14754758 18315731 19059883 15516495 16777450
MESH:D002100 Cachexia Ozone 5.1416183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1415700767 18705752 15721981 16192424 15673190 16124888 16227642 16050911 3786805 10355542 16097048 16011737
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8518788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D003110 Colonic Neoplasms rofecoxib 3.3312902858
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.1015968718 6884620 2869522 10092053 17522070 3732212 10915739 7120509 16227642 7179309 21278145 3786805 4309450 15998439 9327722 15027814 11566570 6623471 7440962 19336974 19085960 16177239
MESH:D020821 Dystonic Disorders Nicotine 6.3217881519
MESH:D004715 Endometriosis rofecoxib 5.1215652904
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.4515959796 16239168 12795759 61145 12631006 19224547 17595544 16045604
MESH:D005355 Fibrosis Carbon Tetrachloride 3.8118705752
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219110552 19900420
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D007410 Intestinal Diseases rofecoxib 5.3915831440
MESH:D007417 Intestinal Polyps rofecoxib 5.6711245490
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9417174718 11408273 11903743 21278145 17157831 16943688 17334410 16239168 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.0318279442 16033810 12586293 12649538 18429990 18472332 15730626 16097048 17721639 16136751 12741479 17823541 10355542 18006644 12898905 14716496 15996030 17698563 16027843 17708605 12546737 12666154 17557913 14512876 12632514 17805973 15673190 16638106 18205269 18251166 18263696 17761835 15362042 17481882 18187930 18054572 17976157 17922224 18420326 17869086 18339082 15338365 15123356 18376398 18481824 15931870 18166357 12389079 18418968 18395914 17766677 16248980 13678700 18277467 12609069 18472094 17565644 18210741 17944888 15818738 18317297 12445418 15057751 15052691 18705752 18412020 16116963 14748882 12445421 15925388 12958196 16015684 14716833 15370692 17640975 17900296 16011737 17714472 17631135 14620537 16192424 12632512 14724832 18395095 17525996 15650968 15893842 15959796 11481614 15876570 12667390 18156304 20821823
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 3.0317565644
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1317285989 15720792 16246199 16964402 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9514706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8121137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8119294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7712014681 15583823
MESH:D008171 Lung Diseases Ozone 3.558266340 19066396
MESH:D055370 Lung Injury Ozone 4.2120417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.566695378 17053015 20135361 20064080 18569708 20869020 20464547 18520028 18816296
MESH:D008175 Lung Neoplasms Ozone 2.568597069 7614698
MESH:D008679 Metaplasia Ozone 5.5510496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009369 Neoplasms Benzo(a)pyrene 5.8111141357
MESH:D009369 Neoplasms Nicotine 5.8116365874
MESH:D009389 Neovascularization, Pathologic Nicotine 5.3916365874
MESH:D010003 Osteoarthritis rofecoxib 4.5316690336
MESH:D010149 Pain, Postoperative rofecoxib 5.8318165598 16678543
MESH:D010538 Peritonitis Ozone 4.4916369182
MESH:D011014 Pneumonia Ozone 4.7918381685 18929643 18007984
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D012640 Seizures Nicotine 3.9717873105
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4810029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.9216785264 11259349 16720336
MESH:D014029 Tobacco Use Disorder Nicotine 5.8117979512 18041664 15735609 18305452
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 5.8111144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.8117053015
Pathway ID Pathway Name
KEGG:04360 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27819
    • No data
    Releated disease ID Related disease Name
    PA443265Adenocarcinoma
    PA443756Colonic Neoplasms
    No data
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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