AutismKB 2.0

Annotation Detail for EPHA5


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Basic Information Top
Gene Symbol:EPHA5 ( CEK7,EHK1,HEK7,TYRO4 )
Gene Full Name: EPH receptor A5
Band: 4q13.1-q13.2
Quick LinksEntrez ID:2044; OMIM: 600004; Uniprot ID:EPHA5_HUMAN; ENSEMBL ID: ENSG00000145242; HGNC ID: 3389
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
No data
Pathway IDPathway Name
200048Ephrin A reverse signaling
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1859Ovarian cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of EPHA5 mRNAdecreases expression 20406850
D000643 Ammonium Chloride Ammonium Chloride affects the expression of EPHA5 mRNAaffects expression 16483693
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of EPHA5 mRNAaffects cotreatment|decreases expression 12634122
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of EPHA5 mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of EPHA5 mRNAaffects cotreatment|decreases expression 12634122
D016572 Cyclosporine Cyclosporine results in decreased expression of EPHA5 mRNAdecreases expression 20106945
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of EPHA5 mRNAaffects cotreatment|decreases expression 12634122
C025299 polyphenols polyphenols results in decreased expression of EPHA5 mRNAdecreases expression 16293270
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of EPHA5 mRNAaffects cotreatment|decreases expression 12634122
C017947 sodium arsenite sodium arsenite results in increased expression of EPHA5 mRNAincreases expression 12634122
C017947 sodium arsenite sodium arsenite results in increased expression of EPHA5 mRNAincreases expression 16014739
D013750 Tetrachloroethylene Tetrachloroethylene results in increased expression of EPHA5 mRNAincreases expression 16010555
C025643 vinclozolin vinclozolin affects the expression of EPHA5 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1217306315 16712894
MESH:D001008 Anxiety Disorders vinclozolin 3.7519015723
MESH:D001943 Breast Neoplasms Tetrachloroethylene 3.8315986119
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1016705839
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.1017306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4118572023
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.736135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.7312371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.7320056578 19524636
MESH:D002779 Cholestasis Cyclosporine 3.0219486331
MESH:D003110 Colonic Neoplasms polyphenols 2.6916293270
MESH:D019465 Craniofacial Abnormalities lead acetate 3.1519769572
MESH:D003456 Cryptorchidism vinclozolin 4.5014966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.2618551238 21346803
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.2619370779
MESH:D005234 Fatty Liver Cyclosporine 2.9919224547
MESH:D005317 Fetal Growth Retardation lead acetate 5.5419769572
MESH:D005355 Fibrosis Cyclosporine 3.3212168785 12639820
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5216417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8716452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006689 Hodgkin Disease sodium arsenite 3.2712676792
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D007248 Infertility, Male sodium arsenite 7.1512646999 15346721
MESH:D007248 Infertility, Male vinclozolin 7.1516467254
MESH:D007249 Inflammation polyphenols 3.1216366677
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cadmium Chloride 10.6216962696
MESH:D007674 Kidney Diseases Cyclosporine 10.6210903974 18776723 8314463
MESH:D007674 Kidney Diseases sodium arsenite 10.6220008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.6716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.6712371664
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9316417039
MESH:D008107 Liver Diseases polyphenols 5.0316698588
MESH:D008107 Liver Diseases Tetrachloroethylene 5.0317267091
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.777678174
MESH:D008113 Liver Neoplasms sodium arsenite 4.7715276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.802876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachloroethylene 6.807955063
MESH:D008171 Lung Diseases sodium arsenite 3.2619095001
MESH:D008175 Lung Neoplasms sodium arsenite 1.8916712894 19931552 17306315 17077188 15276417
MESH:D008545 Melanoma sodium arsenite 2.0516487513 19082730
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009369 Neoplasms sodium arsenite 5.9011559025
MESH:D009369 Neoplasms Tetrachloroethylene 5.9011911487
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009436 Neural Tube Defects sodium arsenite 3.2312854658
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4717306315 15276417
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0918042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.1318220299
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2816039940
MESH:D011472 Prostatitis vinclozolin 5.1318629315
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D012878 Skin Neoplasms sodium arsenite 2.7518572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9012854658
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.4717997062
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2616049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.2611723127 17306315 16452187 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9011813266
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:04360 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27821
    • No data
    No data
    Releated drug ID Related drug Name
    PA452229antidepressants
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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