AutismKB 2.0

Annotation Detail for EPHA7


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Basic Information Top
Gene Symbol:EPHA7 ( EHK3,HEK11 )
Gene Full Name: EPH receptor A7
Band: 6q16.1
Quick LinksEntrez ID:2045; OMIM: 602190; Uniprot ID:EPHA7_HUMAN; ENSEMBL ID: ENSG00000135333; HGNC ID: 3390
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1841Stomach cancer
2004Solid tumor
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of EPHA7 mRNAdecreases expression 19933214
D000643 Ammonium Chloride Ammonium Chloride affects the expression of EPHA7 mRNAaffects expression 16483693
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of EPHA7 mRNAaffects cotreatment|increases expression 18585445
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of EPHA7 mRNAaffects cotreatment|increases expression 18585445
D003024 Clozapine Clozapine results in increased expression of EPHA7 mRNAincreases expression 17266109
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of EPHA7 mRNAdecreases expression 17108234
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of EPHA7 mRNAdecreases expression 19933214
D014212 Tretinoin Tretinoin results in increased expression of EPHA7 mRNAincreases expression 16604517
D014415 Tunicamycin Tunicamycin results in decreased expression of EPHA7 mRNAdecreases expression 17127020
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of EPHA7 mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0815322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 11.4318287403
MESH:D000138 Acidosis Zinc Sulfate 11.437265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000380 Agranulocytosis Clozapine 5.2714617031 12649775 16160616
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.4611874814
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000860 Anoxia Zinc Sulfate 5.267265320
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.5415885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.5416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.5216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9716166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.901917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3316051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 16120746 18850075
MESH:D002386 Cataract Tretinoin 3.1917460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0017333356 16919318 11677210 16105132 15861022 17681005 17110522
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9815668235 15340226 12621046 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.989407595
MESH:D003072 Cognition Disorders Clozapine 5.1817123785
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4915322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.499224671 10589399 9664655 17551590 9125849 16925845 9211117 9142499 14991402 8800419
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.6316402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6317107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.8215331141
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D050171 Dyslipidemias Clozapine 4.3016402076
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.8516714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 12.8518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.2611564622
MESH:D005124 Eye Abnormalities Tretinoin 9.2616938888 9664655
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.9815345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3520067830
MESH:D005355 Fibrosis Tretinoin 9.3517994277
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8111294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.819664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 5.2117063115
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1112621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3115340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.3516870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006948 Hyperkinesis Clozapine 5.1516046005
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007022 Hypotension Zinc Sulfate 4.657265320
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Atrazine 7.2812948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.2817937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.5116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.5115992940 17551590
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.4115237267
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8716482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1016294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2617107899 16140955 19642359 17368321 17294898 19029980 16823087 17301526 19035177 16766008 16891316 16331271 16788101 17217047 17339181 12679006 9834237 19225113 17712046 17506722 19075265 16935935 17649720 15748426 17361223
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008064 Lipidoses Clozapine 4.0817567588
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3518397230 16248980
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2012151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D001523 Mental Disorders Clozapine 4.1816856516
MESH:D008654 Mesothelioma Atrazine 3.591916698
MESH:D024821 Metabolic Syndrome X Clozapine 4.5619142101
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009369 Neoplasms Tretinoin 2.4816946489 16594593
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1814600291
MESH:D009421 Nervous System Malformations Tretinoin 10.189125849
MESH:D009436 Neural Tube Defects Tretinoin 3.169142499
MESH:D009765 Obesity Clozapine 3.0519142110 18515891
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3916936753
MESH:D010146 Pain Tretinoin 3.0416870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010300 Parkinson Disease Atrazine 3.3317218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311222880 11399792 11118676 11896295
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D011618 Psychotic Disorders Clozapine 4.3015331141
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D012135 Respiratory Sounds Atrazine 4.7311874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816283617 16116481
MESH:D012559 Schizophrenia Clozapine 2.7511151749 20580759 18806925 17726453 20521320 20452607 20168265 11763009 17123785 20521326 19369910 20107430 16141801 17667964 18855531
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8016192470
MESH:D012878 Skin Neoplasms Tretinoin 5.8016467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1516026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D015430 Weight Gain Clozapine 4.6216402076 20107430 20564506 16141801 20521320 17502770
MESH:D015431 Weight Loss Clozapine 5.3117933447
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
Pathway ID Pathway Name
KEGG:04360 Axon guidance
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB07970 - 5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide
No data
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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