AutismKB 2.0

Annotation Detail for EPHB2


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Basic Information Top
Gene Symbol:EPHB2 ( CAPB,DRT,EK5,EPHT3,ERK,Hek5,MGC87492,PCBC,Tyro5 )
Gene Full Name: EPH receptor B2
Band: 1p36.12
Quick LinksEntrez ID:2048; OMIM: 600997; Uniprot ID:EPHB2_HUMAN; ENSEMBL ID: ENSG00000133216; HGNC ID: 3393
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200141EphrinB-EPHB pathway
200173Ephrin B reverse signaling
200164Syndecan-2-mediated signaling events
200041EPHB forward signaling
Pathway IDPathway Name
P00005Angiogenesis
Pathway IDPathway Name
500097L1CAM interactions
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1832Congenital abnormality
1934Cancer
Desease Name
prostate cancer
CANCER
colorectal cancer hyperplastic polyposis
No data
Desease Name
Prostate cancer, progression and metastasis of
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of EPHB2 mRNAaffects cotreatment|increases expression 18585445
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of EPHB2 mRNAaffects cotreatment|increases expression 18585445
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of EPHB2 mRNAincreases expression 15336504
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of EPHB2 mRNAincreases expression 12057914
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of EPHB2 mRNAincreases expression 16137721
D014212 Tretinoin Tretinoin affects the expression of EPHB2 mRNAaffects expression 16251210
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.3811850527 18653653
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 6.0515814487
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.6811874814
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.2516412693
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 5.1019898480
MESH:D001172 Arthritis, Rheumatoid Tretinoin 5.1016292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9316206674 16197459
MESH:D001943 Breast Neoplasms Tretinoin 2.2416443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.911917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.5111212258
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 5.2411212258
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.2416051514 16096774
MESH:D002386 Cataract Tretinoin 3.2617460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tretinoin 2.789407595
MESH:D003092 Colitis Tretinoin 4.1217035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839142499 17551590 9224671 16925845 8800419 10589399 9211117 9664655 9125849 14991402
MESH:D004489 Edema, Cardiac Tretinoin 4.9918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3016569247
MESH:D019446 Endotoxemia Lipopolysaccharides 4.8615328337 17637181 15821434
MESH:D005124 Eye Abnormalities Tretinoin 3.8116938888 9664655
MESH:D005334 Fever Lipopolysaccharides 4.329205823 11852909
MESH:D005355 Fibrosis Tretinoin 3.9317994277
MESH:D005909 Glioblastoma Tretinoin 3.1917312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.049664655 14991402
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.6916366002
MESH:D006930 Hyperalgesia Tretinoin 3.4616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D007248 Infertility, Male Atrazine 3.9112948887
MESH:D007249 Inflammation Lipopolysaccharides 6.1112878042 17255318 17237260 17963957 9205823
MESH:D007249 Inflammation Tobacco Smoke Pollution 6.1118590791
MESH:D007410 Intestinal Diseases Tretinoin 4.1817994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.9817255318
MESH:D007569 Jaw Abnormalities Tretinoin 4.2317551590 15992940
MESH:D007938 Leukemia Tretinoin 2.9017143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0216482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1219850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3417339181 16823087 19029980 17294898 19225113 16788101 16766008 17506722 16331271 12679006 15748426 19642359 17217047 9834237 17368321 17712046 16140955 17649720 17107899 19035177 17301526 17361223 16935935 19075265 16891316
MESH:D007970 Leukopenia Lipopolysaccharides 5.1615821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.7612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.7616248980 18397230
MESH:D055370 Lung Injury Lipopolysaccharides 4.4221114838
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 2.7212111688 16288123 3440675 11091918
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D008654 Mesothelioma Atrazine 3.631916698
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.5915006635
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2417596541
MESH:D009369 Neoplasms Tretinoin 2.5416946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.169125849
MESH:D009436 Neural Tube Defects Tretinoin 3.249142499
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4216936753
MESH:D010146 Pain Tretinoin 3.1616870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5515976015
MESH:D010300 Parkinson Disease Atrazine 3.3717218051
MESH:D011014 Pneumonia Lipopolysaccharides 5.0211605937 12224865
OMIM:603688 PROSTATE CANCER/BRAIN CANCER SUSCEPTIBILITY marker/mechanism
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.9210835634
MESH:D012135 Respiratory Sounds Atrazine 11.5311874814
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 11.5318410779
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4516283617 16116481
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 10.388532709
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 10.3818590791
MESH:D012878 Skin Neoplasms Tretinoin 10.3816467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.4715821434
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2617045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0916051514
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 3.4312846360
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9816129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.1316752155
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04360 Axon guidance
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB04395 - Phosphoaminophosphonic Acid-Adenylate Ester
No data
No data
No data

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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