AutismKB 2.0

Annotation Detail for EPHB3


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Basic Information Top
Gene Symbol:EPHB3 ( ETK2,HEK2,TYRO6 )
Gene Full Name: EPH receptor B3
Band: 3q27.1
Quick LinksEntrez ID:2049; OMIM: 601839; Uniprot ID:EPHB3_HUMAN; ENSEMBL ID: ENSG00000182580; HGNC ID: 3394
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
No data
Pathway IDPathway Name
200141EphrinB-EPHB pathway
200041EPHB forward signaling
Pathway IDPathway Name
P00005Angiogenesis
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of EPHB3 mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of EPHB3 mRNAaffects expression 17562736
D015081 2-Naphthylamine 2-Naphthylamine results in increased expression of EPHB3 mRNAincreases expression 18247414
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of EPHB3 mRNAdecreases expression 18247414
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in decreased expression of EPHB3 mRNAdecreases expression 12634122
C406082 monomethylarsonous acid monomethylarsonous acid results in decreased expression of EPHB3 mRNAdecreases expression 20024957
D009538 Nicotine Nicotine results in decreased expression of EPHB3 mRNAdecreases expression 18247414
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of EPHB3 mRNAdecreases expression 19933214
D014212 Tretinoin Tretinoin affects the expression of EPHB3 mRNAaffects expression 16251210
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of EPHB3 mRNAincreases expression 17982090
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0815322242 11752688 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000544 Alzheimer Disease Nicotine 3.3116627626
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.5216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8020146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8016166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.933084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 2.931917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7120419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.7116051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 7.5410977129
MESH:D002386 Cataract Tretinoin 7.5417460283
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 7.922727394
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 7.9219716837
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9816354765 15340226 15668235 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 5.989407595
MESH:D003092 Colitis Tretinoin 10.5117035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 10.5118023891 18200517 16867261 16474422 17936198 16782535 11698051 16804969 17991707
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.4917276891
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4920055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.499125849 17551590 9211117 16925845 9664655 10589399 14991402 9142499 9224671 8800419
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7016781746 11743745 11834606 11739529 14725611 12153990 11461765 2444490 18071297 12540782 19416960 10774834 14986274 14550746 19739265 11529661 15968718 12594235 10915739 19923254 11421492 19164858 17522070 19420014 11287661 17906064 12705907 18713872 16227642 10663392 16177239 15619225 16081117 12392966 16109766 12958197 17562736 19085960 16485898 19370779 16393943
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D020821 Dystonic Disorders Nicotine 6.1617881519
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.8518230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.8518230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.2611564622
MESH:D005124 Eye Abnormalities Tretinoin 9.2616938888 9664655
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.1920067830
MESH:D005355 Fibrosis Tretinoin 16.1917994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 16.1917994277
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.5720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.5711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 11.579664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116959395 18606429 8697196 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 8.0916870215
MESH:D006930 Hyperalgesia Tretinoin 8.0916870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.6318200517
MESH:D007410 Intestinal Diseases Tretinoin 10.7217994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 10.7217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.5116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.5115992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8716482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1016294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2617301526 16891316 17368321 17107899 16140955 17361223 19225113 16823087 12679006 17294898 17506722 16788101 19029980 17712046 17217047 17339181 16935935 17649720 16331271 19075265 15748426 19642359 16766008 19035177 9834237
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3518397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6619014921 19784758 12969438 16611625 19460945 16610002 12587719 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5220195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2012151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2217053015 18816296 6695378 18569708 20869020 20464547 20064080 20135361 18520028
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2219555203 11884234
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 6.1317671175
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009369 Neoplasms Benzo(a)pyrene 8.8711141357
MESH:D009369 Neoplasms Nicotine 8.8716365874
MESH:D009369 Neoplasms Tretinoin 8.8716594593 16946489
MESH:D009389 Neovascularization, Pathologic Nicotine 5.2316365874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1814600291
MESH:D009421 Nervous System Malformations Tretinoin 10.189125849
MESH:D009436 Neural Tube Defects Tretinoin 3.169142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3916936753
MESH:D010146 Pain Acetaminophen 7.0716870215
MESH:D010146 Pain Tretinoin 7.0716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5115976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.3817698068
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816283617 16116481
MESH:D012640 Seizures Nicotine 3.9117873105
MESH:D012871 Skin Diseases monomethylarsonous acid 3.4117431481
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.8216192470
MESH:D012878 Skin Neoplasms Tretinoin 9.8216467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.382093021 20155912
MESH:D013274 Stomach Neoplasms Tretinoin 2.3817261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1516026305 17045167
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.8516785264 11259349 16720336
MESH:D014029 Tobacco Use Disorder Nicotine 5.6615735609 17979512 18305452 18041664
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 8.9711144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.9717053015
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 8.9720375083
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
Pathway ID Pathway Name
KEGG:04360 Axon guidance
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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