AutismKB 2.0

Annotation Detail for EPHB6


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Basic Information Top
Gene Symbol:EPHB6 ( HEP,MGC129910,MGC129911 )
Gene Full Name: EPH receptor B6
Band: 7q34
Quick LinksEntrez ID:2051; OMIM: 602757; Uniprot ID:EPHB6_HUMAN; ENSEMBL ID: ENSG00000106123; HGNC ID: 3396
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
2237Neoplasm metastasis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of EPHB6 mRNAaffects expression 21346803
D006710 Homocysteine Homocysteine results in decreased expression of EPHB6 mRNAdecreases expression 17320366
D016572 Cyclosporine Cyclosporine results in decreased expression of EPHB6 mRNAdecreases expression 20106945
D005492 Folic Acid Folic Acid affects the expression of EPHB6 mRNAaffects expression 17320366
D007052 Ibuprofen Ibuprofen affects the expression of EPHB6 mRNAaffects expression 17070997
C116926 rofecoxib rofecoxib results in decreased expression of EPHB6 mRNAdecreases expression 17070997
D012643 Selenium Selenium results in increased expression of EPHB6 mRNAincreases expression 19244175
C113580 U 0126 U 0126 results in increased expression of EPHB6 mRNAincreases expression 17320366
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000168 Acrocephalosyndactylia U 0126 5.7517694057
MESH:D058186 Acute Kidney Injury Folic Acid 10.0616595132 16316344 17003819
MESH:D058186 Acute Kidney Injury Ibuprofen 10.066375363
MESH:D000230 Adenocarcinoma Ibuprofen 3.2910697514
MESH:D000236 Adenoma Folic Acid 3.9216963246
MESH:D000544 Alzheimer Disease Folic Acid 4.9817116317
MESH:D000544 Alzheimer Disease Ibuprofen 4.9818351690
MESH:D000707 Anaphylaxis Ibuprofen 5.559532969
MESH:D001169 Arthritis, Experimental rofecoxib 4.4816690336
MESH:D001321 Autistic Disorder Folic Acid 2.7621388746
MESH:D001321 Autistic Disorder Homocysteine 2.7616297937 20468076
MESH:D002545 Brain Ischemia Ibuprofen 5.2215837124
MESH:D001943 Breast Neoplasms Folic Acid 3.1516777985
MESH:D002100 Cachexia Ibuprofen 5.8115141370
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 1.7816705839
MESH:D002318 Cardiovascular Diseases Folic Acid 4.1116755160
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D002971 Cleft Lip Folic Acid 4.0921254359
MESH:D002972 Cleft Palate Folic Acid 3.6521254359 8946559
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D003110 Colonic Neoplasms rofecoxib 3.3312902858
MESH:D015179 Colorectal Neoplasms Folic Acid 2.7016985020 17087956 16963246 17116713 17245555
MESH:D003324 Coronary Artery Disease Homocysteine 3.8216379339
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3218551238
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 3.1816886840
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.1321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Selenium 4.1315131321
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.9516133044 18450898 18446180
MESH:D016889 Endometrial Neoplasms Folic Acid 4.1617301261
MESH:D004715 Endometriosis Ibuprofen 10.6815652904
MESH:D004715 Endometriosis rofecoxib 10.6815652904
MESH:D019446 Endotoxemia Ibuprofen 5.3011545620
MESH:D017889 Exfoliation Syndrome Folic Acid 14.5416504073
MESH:D017889 Exfoliation Syndrome Homocysteine 14.5416504073
MESH:D005234 Fatty Liver Cyclosporine 3.1019224547
MESH:D005334 Fever Ibuprofen 4.8116997862
MESH:D005355 Fibrosis Cyclosporine 3.4512168785 12639820
MESH:D005756 Gastritis Folic Acid 5.4617171786
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005901 Glaucoma Folic Acid 12.7416504073
MESH:D005901 Glaucoma Homocysteine 12.7416504073
MESH:D006330 Heart Defects, Congenital Folic Acid 7.8617286298 16524890
MESH:D006330 Heart Defects, Congenital Homocysteine 7.8619638421
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006679 HIV Seropositivity Folic Acid 5.8317209195
MESH:D020138 Hyperhomocysteinemia Folic Acid 10.5616433478 16865747 16755160 16395265 16397167
MESH:D020138 Hyperhomocysteinemia Homocysteine 10.5618234410 17369066 17292331
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D006984 Hypertrophy Ibuprofen 5.2216672835
MESH:D007235 Infant, Premature, Diseases Ibuprofen 6.2116133044
MESH:D007249 Inflammation Ibuprofen 3.553291741
MESH:D007251 Influenza, Human Selenium 4.5716624496
MESH:D007410 Intestinal Diseases rofecoxib 5.3415831440
MESH:D007417 Intestinal Polyps rofecoxib 5.6311245490
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.468314463 18776723 10903974
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.9516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D007948 Leukemia, Monocytic, Acute U 0126 5.6416972261
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 3.0817565644
MESH:D008107 Liver Diseases Folic Acid 3.0916877991
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3917718048
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 6.9310697514
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.9315318939
MESH:D019767 Maxillofacial Abnormalities Folic Acid 6.0316832597
MESH:D008591 Meningomyelocele Homocysteine 5.8416602021
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009203 Myocardial Infarction Homocysteine 3.8017412321
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2018551238
MESH:D009395 Nephritis, Interstitial Ibuprofen 5.366375363
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009410 Nerve Degeneration Ibuprofen 4.5710961664
MESH:D009436 Neural Tube Defects Folic Acid 4.1017438019
MESH:D009503 Neutropenia Folic Acid 4.7616322990
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6616049721 12819281
MESH:D010003 Osteoarthritis Ibuprofen 8.757009135
MESH:D010003 Osteoarthritis rofecoxib 8.7516690336
MESH:D010051 Ovarian Neoplasms U 0126 3.4716211241
MESH:D010146 Pain Ibuprofen 4.123291741
MESH:D010149 Pain, Postoperative Ibuprofen 13.0316678543
MESH:D010149 Pain, Postoperative rofecoxib 13.0318165598 16678543
MESH:D010190 Pancreatic Neoplasms Ibuprofen 3.5612384795
MESH:D010300 Parkinson Disease Homocysteine 3.6416275827
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011471 Prostatic Neoplasms Ibuprofen 4.1917409433
MESH:D011507 Proteinuria Ibuprofen 4.896375363
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D051437 Renal Insufficiency Folic Acid 5.0815728788
MESH:D012559 Schizophrenia Folic Acid 4.3616641680
MESH:D012559 Schizophrenia Homocysteine 4.3616641680
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6818551238
MESH:D012871 Skin Diseases Folic Acid 3.3018709164
MESH:D013118 Spinal Cord Diseases Folic Acid 5.8316361298
MESH:D013274 Stomach Neoplasms Folic Acid 2.7017171786
MESH:D020521 Stroke Folic Acid 4.5216517955
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3616049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6510091137
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D020301 Vasospasm, Intracranial Ibuprofen 5.5319057314
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
KEGG:04360 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27828
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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