AutismKB 2.0

Annotation Detail for ERBB4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ERBB4 ( HER4,MGC138404,p180erbB4 )
Gene Full Name: v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Band: 2q34
Quick LinksEntrez ID:2066; OMIM: 600543; Uniprot ID:ERBB4_HUMAN; ENSEMBL ID: ENSG00000178568; HGNC ID: 3432
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04012ErbB signaling pathway
hsa04020Calcium signaling pathway
hsa04144Endocytosis
No data
Pathway IDPathway Name
200009ErbB4 signaling events
200136ErbB receptor signaling network
Pathway IDPathway Name
P00018EGF receptor signaling pathway
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1934Cancer
2069Schizophrenia
Desease Name
PSYCH
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C076996 27-hydroxycholesterol 27-hydroxycholesterol results in decreased expression of ERBB4 mRNAdecreases expression 17872378
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of ERBB4 mRNAdecreases expression 12419474
C107875 6-(methylamino)pyrido(3,4-d)pyrimidine 6-(methylamino)pyrido(3,4-d)pyrimidine results in decreased activity of ERBB4 proteindecreases activity 15572027
D000082 Acetaminophen Acetaminophen affects the expression of ERBB4 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of ERBB4 mRNAincreases expression 20458559
19769630
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ERBB4 mRNAdecreases expression 12419474
D003520 Cyclophosphamide ERBB4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D003907 Dexamethasone Dexamethasone results in increased expression of ERBB4 mRNAincreases expression 16144937
D004317 Doxorubicin ERBB4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D004958 Estradiol ERBB4 protein promotes the reaction [Estradiol results in increased expression of PGR mRNA]increases expression|increases reaction 20550710
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ERBB4 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of ERBB4 mRNAdecreases expression 19619570
17872378
D005047 Etoposide Etoposide results in decreased expression of ERBB4 mRNAdecreases expression 15228094
D005472 Fluorouracil ERBB4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D006220 Haloperidol Haloperidol results in increased expression of ERBB4 proteinincreases expression 18184445
D007052 Ibuprofen Ibuprofen affects the cleavage of ERBB4 proteinaffects cleavage 12777371
C051890 irinotecan irinotecan metabolite results in increased expression of ERBB4 mRNAincreases expression 15956246
C051890 irinotecan irinotecan results in increased expression of ERBB4 mRNAincreases expression 15956246
D007649 Ketamine Ketamine results in decreased expression of ERBB4 mRNAdecreases expression 20000043
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of ERBB4 mRNAincreases expression 12634122
C406082 monomethylarsonous acid [monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of ERBB4 promoteraffects acetylation|affects methylation 18448484
D009151 Mustard Gas IL10 protein affects the reaction [Mustard Gas affects the expression of ERBB4 mRNA]affects expression|affects reaction 16173061
D017239 Paclitaxel ERBB4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
C017947 sodium arsenite [sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of ERBB4 promoteraffects acetylation|affects methylation 18448484
C025462 sulindac sulfide sulindac sulfide affects the cleavage of ERBB4 proteinaffects cleavage 12777371
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ERBB4 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ERBB4 mRNAdecreases expression 19619570
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7015322242 11752688 14514962
MESH:D058186 Acute Kidney Injury Ibuprofen 4.316375363
MESH:D000230 Adenocarcinoma arsenic trioxide 13.1611798837 19825857
MESH:D000230 Adenocarcinoma Doxorubicin 13.1617418594
MESH:D000230 Adenocarcinoma Estradiol 13.1611473722
MESH:D000230 Adenocarcinoma Fluorouracil 13.1617638652
MESH:D000230 Adenocarcinoma Ibuprofen 13.1610697514
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7517306315 16712894
MESH:D000419 Albuminuria Doxorubicin 4.4021441931
MESH:D000544 Alzheimer Disease 27-hydroxycholesterol 6.8520157255 14523054
MESH:D000544 Alzheimer Disease Ibuprofen 6.8518351690
MESH:D000544 Alzheimer Disease sulindac sulfide 6.8518759972
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.0110965797
MESH:D000707 Anaphylaxis Ibuprofen 5.099532969
MESH:D000740 Anemia Fluorouracil 8.2416511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.2411748828
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.4515014928
MESH:D001169 Arthritis, Experimental Dexamethasone 3.4517659584
MESH:D001249 Asthma Mustard Gas 2.6710378619
MESH:D050197 Atherosclerosis 27-hydroxycholesterol 4.3411166758 9059518
MESH:D001321 Autistic Disorder Acetaminophen 2.1218445737
MESH:D001321 Autistic Disorder Haloperidol 2.1218080171 19368416
MESH:D001768 Blister Mustard Gas 5.0119167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.5016206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.5012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 11.6514601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 11.6514601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.4215867366
MESH:D002545 Brain Ischemia Ibuprofen 4.7315837124
MESH:D001932 Brain Neoplasms Doxorubicin 3.6817150277
MESH:D001943 Breast Neoplasms Cyclophosphamide 3.6812006526 18234424 17388661 11325840 18323546 15093573 15136595 16978400 17020986
MESH:D001943 Breast Neoplasms Doxorubicin 3.6817983394 16096432 15668708 18695136 18234424 16264153 16322301 18628466 17369602 15939500 17426702 18382427 19526202 15136595 15993339 16826403 16595493 15994142 11325840 16935488 16115903 15634643 15567936 15692762
MESH:D001943 Breast Neoplasms Estradiol 3.6817289903 19861407 12948864 17261762 16675129 14630087 18497071 17018787
MESH:D001943 Breast Neoplasms Etoposide 3.6816322251
MESH:D001943 Breast Neoplasms Fluorouracil 3.6819217205 16595493 16557594 16110121 15136595 18357371 18608205
MESH:D001943 Breast Neoplasms Paclitaxel 3.6811325840 16273361 18234424 15136595 18223236 16244791 16115903 18323546
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6820435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.0115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.8317687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1911589617
MESH:D002100 Cachexia Ibuprofen 5.3215141370
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D002276 Carcinoid Tumor Doxorubicin 11.8516051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.8516051944
MESH:D002277 Carcinoma Fluorouracil 7.7817121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.7816835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.513084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.5114691202 16217749 11135700 15553829 15073043
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 16.5119701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 16.5118059187 17876044 16234567 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.5116924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.5117971768 17045692 16799960 16332177 18930000 17088986
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 16.5116313753
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.5115276417 17306315 16507464
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.7416152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.4012391285
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7219014326
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 10.4916201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.491485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.4918695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9812490120
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.366189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.3616757204 16280240 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.3618572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.4317928571 16109756 15792986 16269455 17007740 17131338 16278810 18627295 17974986 17329180 16952015 17351982 16612575 15505089 15811867 17924179 17382496 16651473 16242529 16731534 16455267 16364871 17308081 17519947 15476868
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8916243910 17334414
MESH:D002375 Catalepsy Haloperidol 4.7615215559 1977408
MESH:D002386 Cataract Acetaminophen 2.4910977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.2918566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 15.292727394
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 15.2919716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.2920056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0412621046 15340226 16354765 8697196 15668235
MESH:D003110 Colonic Neoplasms Dexamethasone 5.7815824018
MESH:D003110 Colonic Neoplasms Fluorouracil 5.7816510598 18772588 17725105 17169374 15001691 16340194 17172411 17016597 17287894 17018589
MESH:D003110 Colonic Neoplasms irinotecan 5.7817725105 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 6.3320501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 6.3318802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 6.3317695437 17454858 16282729 17401013 18802399 17094418 18383874 16303861 16331619 18509181 16524972 15148649 20501625 17594712 14970324 18448328 18288408 17016601 15289873 18949393 16391804 17255274
MESH:D015179 Colorectal Neoplasms irinotecan 6.3318259882 15273666 16391804 17454858 17159606 18509181 16303861
MESH:D015179 Colorectal Neoplasms Paclitaxel 6.3318802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9314669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0412609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7310525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.7317728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7310048152 15322242 20055451
MESH:D003556 Cystitis Cyclophosphamide 4.8318433785 17979934 12913760 17010015 10498854 16651033 16989017 11948286 18372110 18483878 16413132 18295254 18093676 12161096 15276878 10700343 16614059 18710439 12388444 15643279
MESH:D007644 Darier Disease Fluorouracil 4.6416733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 10.4415213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 10.4420210726
MESH:D003704 Dementia Haloperidol 4.4411575062
MESH:D003715 Dengue 27-hydroxycholesterol 5.5319427377
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.2612438553
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.9411751995 15331540 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1718772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6317107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2819279558
MESH:D003967 Diarrhea Dexamethasone 3.557237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.9119085960 19420014 11287661 17522070 18071297 11421492 11743745 12392966 15968718 15619225 16109766 12958197 18713872 12153990 14986274 12540782 16081117 19923254 11834606 14550746 16177239 2444490 11461765 17562736 19416960 19370779 11739529 10774834 16227642 16485898 14725611 19164858 17906064 10663392 16781746 12594235 10915739 16393943 19739265 11529661 12705907
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 5.9117416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.9120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Doxorubicin 7.7418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.7411462148
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.4618446180 16133044 18450898
MESH:D004485 Eczema Dexamethasone 4.3112438553
MESH:D004487 Edema Dexamethasone 10.7519703484
MESH:D004487 Edema Mustard Gas 10.759260866 11402378 11428631 11428647
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.7512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7515322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 27-hydroxycholesterol 5.0317410599
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.2117359293
MESH:D016889 Endometrial Neoplasms Estradiol 7.2119148513 11473722 18566989
MESH:D004715 Endometriosis Ibuprofen 8.7915652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.7910568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0118037988
MESH:D019446 Endotoxemia Ibuprofen 4.8111545620
MESH:D004802 Eosinophilia Cyclophosphamide 4.0711006010
MESH:D004890 Erythema Mustard Gas 5.019357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.1512903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.1516481741 15173087 16785472 16337965 17638652
MESH:D004938 Esophageal Neoplasms Paclitaxel 7.1516481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver arsenic trioxide 3.1515073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005334 Fever Ibuprofen 4.4516997862
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4419069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8020067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1116904648
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5316452187
MESH:D005909 Glioblastoma Doxorubicin 3.2517150277
MESH:D005910 Glioma Fluorouracil 2.8116145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.3611389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.8816376943 11014644 15172196
MESH:D006261 Headache Ketamine 5.8611554966
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.5815692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.5815162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2511294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.3812587719 17875725 16330681 16879835 16707910 18006777 17888722 16244372 16144979 14766674 18674790 16495754 16244371
MESH:D006333 Heart Failure Doxorubicin 3.2517481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7615692506
MESH:D006467 Hemophilia A Cyclophosphamide 5.1411918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.3814986274
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7415340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.027520565
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D006561 Herpes Simplex Etoposide 4.4110809021
MESH:D006689 Hodgkin Disease Cyclophosphamide 16.4716135485 17606976
MESH:D006689 Hodgkin Disease Doxorubicin 16.4717606976 15147373 18501091
MESH:D006689 Hodgkin Disease Etoposide 16.4718180244 15147373 16135485 16200630 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 16.4712676792
MESH:D019584 Hot Flashes Estradiol 3.6017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8915340226 16354765 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.5816870215
MESH:D006937 Hypercholesterolemia 27-hydroxycholesterol 5.0217873880
MESH:D006973 Hypertension Dexamethasone 5.0617042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0618850075 18670907
MESH:D006984 Hypertrophy Ibuprofen 4.8416672835
MESH:D007154 Immune System Diseases Cyclophosphamide 5.1816076520
MESH:D007235 Infant, Premature, Diseases Ibuprofen 5.6816133044
MESH:D007248 Infertility, Male Cyclophosphamide 6.7316517039 7193160
MESH:D007248 Infertility, Male sodium arsenite 6.7312646999 15346721
MESH:D007249 Inflammation Dexamethasone 11.3911099482 8960868
MESH:D007249 Inflammation Ibuprofen 11.393291741
MESH:D007249 Inflammation Mustard Gas 11.3911428620 17524151 11402378 16001271 9260866 11428647 11428631 8975870 9357497
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.3912878042 12200463
MESH:D007333 Insulin Resistance Estradiol 2.8716627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007674 Kidney Diseases Acetaminophen 13.7415629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 13.7415699352 15369732 16775033
MESH:D007674 Kidney Diseases Estradiol 13.7415618244
MESH:D007674 Kidney Diseases sodium arsenite 13.7420008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0116707910
MESH:D007680 Kidney Neoplasms Estradiol 7.0715610895
MESH:D007680 Kidney Neoplasms Fluorouracil 7.0716985049
MESH:D007938 Leukemia arsenic trioxide 6.3615070760
MESH:D007938 Leukemia Cyclophosphamide 6.3610602166
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0116085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4318172266 17802794 17658394 18587576 17296974 17008537
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6617077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.2414633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 8.2410373061
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6219077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1117050201 16968895 20471514 16467208 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1211468182 12018890 16112521 19225113 16330433 16966277 17107899 17217047 16891316 16331271 19642359 15336539 19075265 11161223 17649720 15622746 19035177 15748426 9834237 17869043 12712474 17712046 16823087 15213294 12679006
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2016882451
MESH:D007970 Leukopenia Cyclophosphamide 4.8111830472 10052129
MESH:D008080 Liposarcoma Paclitaxel 4.6817353645
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 4.8316718785
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.8316439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.8314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8312878042
MESH:D008107 Liver Diseases Acetaminophen 1.5919460945 11587558 19014921 16611625 12969438 12587719 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1016871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 10.2414682389
MESH:D008113 Liver Neoplasms Fluorouracil 10.2417045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms sodium arsenite 10.2416712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.2416984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.3220377131
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.3217085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.3212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2315213294
MESH:D008171 Lung Diseases Mustard Gas 7.2118161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 7.2119095001
MESH:D008175 Lung Neoplasms arsenic trioxide 10.4219825857 11798837
MESH:D008175 Lung Neoplasms Dexamethasone 10.4215824018 11195469
MESH:D008175 Lung Neoplasms Doxorubicin 10.426189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 10.4215246190
MESH:D008175 Lung Neoplasms Mustard Gas 10.428781369 3148597
MESH:D008175 Lung Neoplasms sodium arsenite 10.4215276417 17077188 19931552 17306315 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.4211884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6415086387
MESH:D008223 Lymphoma Cyclophosphamide 12.1312854902
MESH:D008223 Lymphoma Doxorubicin 12.1316098063
MESH:D008223 Lymphoma Etoposide 12.1312854902 12556972
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.4516675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 13.9511911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 13.9517654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 13.9514749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4215621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.5815458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.5811408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 9.5810697514
MESH:D020149 Manganese Poisoning Estradiol 4.3319453300
MESH:D008545 Melanoma marker/mechanism 19718025
MESH:D008545 Melanoma Doxorubicin 5.0816827129
MESH:D008545 Melanoma Paclitaxel 5.0816342250 12040289 12025231
MESH:D008545 Melanoma sodium arsenite 5.0819082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 10.3319513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 10.3316388313
MESH:D001523 Mental Disorders Haloperidol 3.8616856516
MESH:D008654 Mesothelioma Doxorubicin 3.0017638057
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.7417671175
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3615792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.5118986760 16757204
MESH:D052016 Mucositis Doxorubicin 11.9117415656
MESH:D052016 Mucositis irinotecan 11.9117159606
MESH:D009101 Multiple Myeloma arsenic trioxide 11.6119417148 14977855 15949261 11468182 19549372
MESH:D009101 Multiple Myeloma Dexamethasone 11.6116118317 15867202 15744524
MESH:D009101 Multiple Myeloma Paclitaxel 11.6114749477
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.2816882451 16105982
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.289809623
MESH:D009203 Myocardial Infarction Doxorubicin 2.8915857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1616810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8116624393
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.3518259882
MESH:D009362 Neoplasm Metastasis irinotecan 9.3518259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 9.3515867366
MESH:D009369 Neoplasms Cyclophosphamide 7.9918854779
MESH:D009369 Neoplasms Fluorouracil 7.9918239605 18600527 16928823
MESH:D009369 Neoplasms sodium arsenite 7.9911559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5220056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5817289903
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.836375363
MESH:D009401 Nephrosis Doxorubicin 4.6216899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8715640375 16889571
MESH:D009410 Nerve Degeneration Ibuprofen 4.2710961664
MESH:D009421 Nervous System Malformations Estradiol 8.9711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9714600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.0110525206
MESH:D009436 Neural Tube Defects sodium arsenite 7.0112854658
MESH:D009447 Neuroblastoma Cyclophosphamide 11.1115176712 8761367 16115947
MESH:D009447 Neuroblastoma Doxorubicin 11.1115555623
MESH:D009447 Neuroblastoma irinotecan 11.118761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7518514411
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 11.0312837982 8761367
MESH:D017599 Neuroectodermal Tumors irinotecan 11.038761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3416436463
MESH:D009503 Neutropenia Cyclophosphamide 9.058291058
MESH:D009503 Neutropenia Mustard Gas 9.057688884 16761898
MESH:D009845 Oligospermia Cyclophosphamide 4.5616517039
MESH:D010003 Osteoarthritis Ibuprofen 4.047009135
MESH:D010014 Osteolysis Paclitaxel 4.8315867366
MESH:D012516 Osteosarcoma Doxorubicin 3.9915930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.9316624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 10.9319401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 10.9311161223
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.9315276417 17306315
MESH:D010146 Pain Acetaminophen 10.7116870215
MESH:D010146 Pain Cyclophosphamide 10.7112161096 18093676
MESH:D010146 Pain Ibuprofen 10.713291741
MESH:D010149 Pain, Postoperative Ibuprofen 11.5016678543
MESH:D010149 Pain, Postoperative Ketamine 11.5011554966
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 15.7815580305
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 15.7811332152
MESH:D010190 Pancreatic Neoplasms Etoposide 15.7819003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.7819003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Ibuprofen 15.7812384795
MESH:D010235 Paraganglioma arsenic trioxide 4.0219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.3511550810
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0117983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0117638057
MESH:D011041 Poisoning Mustard Gas 3.6615727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 7.5321297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 7.5321297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0411399792 11118676 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7520887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.9119131511
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.9117136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.9116729912 15749863 18437689 16868541 15897917 16888761
MESH:D011471 Prostatic Neoplasms Estradiol 2.9116740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.9117172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.9119082440 18626508
MESH:D011471 Prostatic Neoplasms Ibuprofen 2.9117409433
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.9117136230 17172428 16729912 16356831
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.9116039940
MESH:D011507 Proteinuria Ibuprofen 4.486375363
MESH:D011537 Pruritus Mustard Gas 3.9418058305
MESH:D011595 Psychomotor Agitation Haloperidol 4.8011575062
MESH:D011618 Psychotic Disorders Haloperidol 4.1411575062
MESH:D011649 Pulmonary Alveolar Proteinosis 27-hydroxycholesterol 6.2415466366
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 5.8116636934
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.8117720292 17266442 17620002 17894541 10334151
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8818722050 15538739 18286688 16160472
MESH:D051437 Renal Insufficiency Doxorubicin 4.0717922066
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.8718379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012509 Sarcoma Doxorubicin 3.8615625365 15675481 16767912 17203757 18313854 17710206
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 16.4716646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 16.4716326096 14601052
MESH:D012512 Sarcoma, Ewing's Etoposide 16.4714601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6417846226
MESH:D012559 Schizophrenia Haloperidol 4.4819369910 1830565 20107430 18513383
MESH:D012559 Schizophrenia Ketamine 4.4820000043
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.6816636934
MESH:D012871 Skin Diseases monomethylarsonous acid 5.2417431481
MESH:D012871 Skin Diseases Mustard Gas 5.2412880345 15451306 16961503
MESH:D012878 Skin Neoplasms marker/mechanism 19718025
MESH:D012878 Skin Neoplasms Doxorubicin 13.0015692506
MESH:D012878 Skin Neoplasms sodium arsenite 13.0019524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.008532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.0016192470
MESH:D019082 Smith-Lemli-Opitz Syndrome 27-hydroxycholesterol 5.8711254748
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4216767912 17203757 15625365
OMIM:270800 SPASTIC PARAPLEGIA 5A, AUTOSOMAL RECESSIVE 27-hydroxycholesterol 6.2219812052
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.3616517039
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6812854658
MESH:D013272 Stomach Diseases Dexamethasone 4.1715472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.6617007042
MESH:D013274 Stomach Neoplasms Fluorouracil 4.6616951190 17522103 18567086 17498489 19015929 16424979 15786421 18396642 19084572 17172411
MESH:D013274 Stomach Neoplasms irinotecan 4.6615723263
MESH:D013274 Stomach Neoplasms Paclitaxel 4.6618396642 18506536
MESH:D013276 Stomach Ulcer Dexamethasone 3.3515138204
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.9012837982
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.5620210726
MESH:D024801 Tauopathies Paclitaxel 4.6616930453
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.9519014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 6.9517909728 16010429
MESH:D013978 Tibial Fractures Estradiol 4.5319048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8516280240
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8115213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.2212845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 15.2214692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 15.2217653716
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 15.2220375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 15.2217306315 11723127 16712894 16452187
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.0416803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.0411813266
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.5118645019
MESH:D014605 Uveitis Dexamethasone 4.671336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020301 Vasospasm, Intracranial Ibuprofen 5.0419057314
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0717334414 17638931 17678736 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04144 Endocytosis
KEGG:04012 ErbB signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27847
    • Releated gene ID Related gene Name
    PA28963GRB7
    Releated disease ID Related disease Name
    PA443265Adenocarcinoma
    PA444818Lung Neoplasms
    PA444903Melanoma
    PA447216Schizophrenia
    PA443560Breast Neoplasms
    PA443378Anorexia
    PA443899Diarrhea
    PA443937Drug Toxicity
    PA444153Fatigue
    PA445048Nausea
    PA446051Vomiting
    Releated drug ID Related drug Name
    PA451743trastuzumab
    PA165291472neratinib
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved