AutismKB 2.0

Annotation Detail for EYA4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:EYA4 ( CMD1J,DFNA10 )
Gene Full Name: eyes absent homolog 4 (Drosophila)
Band: 6q23.2
Quick LinksEntrez ID:2070; OMIM: 603550; Uniprot ID:EYA4_HUMAN; ENSEMBL ID: ENSG00000112319; HGNC ID: 3522
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2096Otitis media
2207Deafness
Desease Name
protein quantitative trait loci
Desease Name
Protein quantitative trait loci
Desease Name
Deafness, autosomal dominant 10
Cardiomyopathy, dilated, 1J
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of EYA4 mRNAdecreases expression 18648102
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EYA4 mRNAdecreases expression 19150397
D008345 Manganese Manganese results in decreased expression of EYA4 mRNAdecreases expression 17175027
C025340 manganese chloride manganese chloride results in decreased expression of EYA4 mRNAdecreases expression 17175027
C406082 monomethylarsonous acid [monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of EYA4 promoteraffects acetylation|affects methylation 18448484
C017947 sodium arsenite [sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of EYA4 promoteraffects acetylation|affects methylation 18448484
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of EYA4 mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 14514962 11752688
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.903712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.1415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.3516712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000756 Anemia, Sideroblastic Manganese 11.9916910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 11.9916910769
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.461440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.143581430 7296757
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.1416507464 17306315 15276417
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4418572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated marker/mechanism
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 17.647505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.6420889678
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 17.6419716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 17.6420056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3519486331 9022650
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2016354765 15340226 15668235 8697196 12621046
MESH:D015179 Colorectal Neoplasms marker/mechanism 21278247
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
OMIM:601316 DEAFNESS, AUTOSOMAL DOMINANT 10 marker/mechanism
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1511298694 18759878 14531868 8156756 8970840 12868966 2524372 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.793621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.9211289319 7440962 9022650 18289764 6482804 18692083 6679447 16192314 9653073 18648102 8291058 1440618 9328219
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.583581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5820426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0816452187
MESH:D005909 Glioblastoma Manganese 4.0817043766
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.4012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4918606429 8697196 16354765 15340226 16959395
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007248 Infertility, Male sodium arsenite 3.1615346721 12646999
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812878042 12200463
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.469022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases sodium arsenite 2.9420008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.206582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3515034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms sodium arsenite 4.7415276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7416984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.27598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2712151625
MESH:D008171 Lung Diseases sodium arsenite 3.3519095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.3717306315 19931552 16712894 15276417 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3711884234 19555203
MESH:D020149 Manganese Poisoning Manganese 5.9616551646 16568477 19453300
MESH:D008545 Melanoma sodium arsenite 2.0616487513 19082730
MESH:D009069 Movement Disorders Manganese 5.3116551646
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms sodium arsenite 2.6111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0220056578
MESH:D009410 Nerve Degeneration Manganese 4.4816551646
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.836679447
MESH:D009436 Neural Tube Defects sodium arsenite 7.8312854658
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.684026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5015276417 17306315
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010300 Parkinson Disease Manganese 3.4511181820
MESH:D020734 Parkinsonian Disorders Manganese 4.7316140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2516039940
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012871 Skin Diseases monomethylarsonous acid 3.4317431481
MESH:D012878 Skin Neoplasms sodium arsenite 5.9718572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9716192470
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0112854658
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.096587162 1399818 7505956 6582329 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 9.018074119
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 9.0120375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 9.0116712894 16452187 17306315 11723127
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0311813266
MESH:D014652 Vascular Diseases sodium arsenite 4.8217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27934
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved