AutismKB 2.0

Annotation Detail for ERG


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ERG ( erg-3,p55 )
Gene Full Name: v-ets erythroblastosis virus E26 oncogene homolog (avian)
Band: 21q22.2
Quick LinksEntrez ID:2078; OMIM: 165080; Uniprot ID:ERG_HUMAN; ENSEMBL ID: ENSG00000157554; HGNC ID: 3446
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
No data
Pathway IDPathway Name
P00047PDGF signaling pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
H00035Ewing's sarcoma
Cancers of soft tissues and bone
Desease IDDesease Name
1740Alzheimer's disease
1831Prostate cancer
1935Ewings sarcoma
1983Down syndrome
2051Leukemia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ERG mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ERG mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ERG mRNAaffects expression 16483693
D000728 Androgens Androgens promotes the reaction [TOP2B protein results in increased mutagenesis of ERG gene]increases mutagenesis|increases reaction 20601956
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of ERG mRNAincreases expression 17403535
C014347 decitabine decitabine results in decreased methylation of ERG promoter alternative formdecreases methylation 19108891
C014347 decitabine decitabine results in increased expression of ERG mRNAincreases expression 19194470
C014347 decitabine decitabine results in increased expression of ERG mRNA alternative formincreases expression 19108891
D005419 Flavonoids Flavonoids results in decreased expression of ERG mRNAdecreases expression 18035473
C065180 fluvastatin [zoledronic acid co-treated with fluvastatin] results in increased expression of ERG mRNAaffects cotreatment|increases expression 16996129
D020366 Methylmethacrylate Methylmethacrylate results in increased expression of ERG mRNAincreases expression 16916219
C016766 sulforafan sulforafan inhibits the reaction [AR protein binds to ERG enhancer]affects binding|decreases reaction 19805354
C016766 sulforafan sulforafan results in decreased expression of ERG mRNAdecreases expression 19805354
C016766 sulforafan sulforafan results in decreased expression of ERG proteindecreases expression 19805354
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of ERG mRNAincreases expression 18087596
C012589 trichostatin A trichostatin A results in decreased expression of ERG mRNAdecreases expression 19805354
C025643 vinclozolin vinclozolin affects the expression of ERG mRNAaffects expression 19015723
C088658 zoledronic acid [zoledronic acid co-treated with fluvastatin] results in increased expression of ERG mRNAaffects cotreatment|increases expression 16996129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D058186 Acute Kidney Injury zoledronic acid 4.5119715164
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.5620200999
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.6315814487
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.783712494
MESH:D011125 Adenomatous Polyposis Coli sulforafan 5.3217942926
MESH:D000544 Alzheimer Disease Androgens 3.6217917157 17182789
MESH:D001008 Anxiety Disorders vinclozolin 3.6819015723
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.6715014928
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.1919898480
MESH:D001327 Autoimmune Diseases sulforafan 5.6519761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1211289319 1440618
MESH:D001859 Bone Neoplasms zoledronic acid 5.0216121404 16778634 19442620 15867366 11697798 17312309
MESH:D001862 Bone Resorption zoledronic acid 4.768053405 11869084 16769263 18404659 15845617 18496637
MESH:D001943 Breast Neoplasms Androgens 2.1517018787
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.1516978400 11325840 15093573 17388661 17020986 18323546 15136595 18234424 12006526
MESH:D001943 Breast Neoplasms decitabine 2.1518320071 19208741
MESH:D001943 Breast Neoplasms zoledronic acid 2.1516096432 18695136
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.727296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 4.7219701751
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.9716152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 6.1911212258
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 6.1919233551
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 11.097296757
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 11.0916201981
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 11.0918507039
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.1519215824
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 5.1511212258
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.786135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.787505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.199022650 19486331
MESH:D003110 Colonic Neoplasms decitabine 2.3417616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D003327 Coronary Disease fluvastatin 4.8416142594
MESH:D016638 Critical Illness Androgens 6.1416670151
MESH:D003456 Cryptorchidism vinclozolin 4.4114966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0918551238
MESH:D003556 Cystitis Cyclophosphamide 5.0817979934 16413132 12161096 10498854 11948286 15276878 18483878 15643279 10700343 16614059 16989017 12388444 18295254 12913760 18372110 18093676 18433785 18710439 16651033 17010015
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8711906362 2524372 11298694 14531868 8970840 8156756 12868966 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.552952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.1115331540 11751995 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2318772604
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.9021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.909328219 1440618 18692083 16192314 8291058 18289764 7440962 11289319 18648102 6482804 9653073 6679447 9022650
MESH:D004701 Endocrine Gland Neoplasms decitabine 14.3619294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 14.3619294695
MESH:D004802 Eosinophilia Cyclophosphamide 4.2911006010
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005264 Femoral Fractures zoledronic acid 5.9116234978
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4016417039
MESH:D005909 Glioblastoma trichostatin A 3.8618801729
MESH:D018316 Gliosarcoma Cyclophosphamide 5.6011389073
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.1116376943 11014644 15172196
MESH:D006258 Head and Neck Neoplasms decitabine 3.5219215824
MESH:D006467 Hemophilia A Cyclophosphamide 5.3611918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.6314986274
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006628 Hirsutism Androgens 6.1817019078 16914592
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.8317606976 16135485
MESH:D006930 Hyperalgesia zoledronic acid 4.2916769263
MESH:D017588 Hyperandrogenism Androgens 5.8317019078
MESH:D006934 Hypercalcemia zoledronic acid 5.1019622757 18089816
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006996 Hypocalcemia zoledronic acid 6.2912669777
MESH:D007154 Immune System Diseases Cyclophosphamide 5.4316076520
MESH:D007248 Infertility, Male Cyclophosphamide 11.6016517039 7193160
MESH:D007248 Infertility, Male decitabine 11.6017581917
MESH:D007248 Infertility, Male vinclozolin 11.6016467254
MESH:D007249 Inflammation Flavonoids 5.6317296493
MESH:D007249 Inflammation Tobacco Smoke Pollution 5.6318590791
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.5116705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.516582329
MESH:D007938 Leukemia marker/mechanism 19108891
MESH:D007938 Leukemia Cyclophosphamide 6.7810602166
MESH:D007938 Leukemia decitabine 6.7819235587 18980019
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5218587576 17658394 17296974 17802794 18172266 17008537
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.8218089816
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.1310373061
MESH:D007951 Leukemia, Myeloid decitabine 4.0618454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.3017679729 18704418 18460780 19387464 18206229 19010910
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.3018206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.5618055864
MESH:D007970 Leukopenia Cyclophosphamide 5.0510052129 11830472
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8116417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.239327722 15034207
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.177678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.002876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.00598648 1399818 3712494 6587162
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 2.723440675 11091918 16288123 12111688
MESH:D008223 Lymphoma Cyclophosphamide 7.9912854902
MESH:D008223 Lymphoma decitabine 7.9919470736
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.6516675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.2111911406
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 3.7517312309
MESH:D008545 Melanoma decitabine 3.7517785578 16505122
MESH:D008545 Melanoma trichostatin A 3.7516505122
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.8716388313
MESH:D008654 Mesothelioma zoledronic acid 3.7716675582
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.3915006635
MESH:D009101 Multiple Myeloma decitabine 17.7518172295
MESH:D009101 Multiple Myeloma fluvastatin 17.7516996129
MESH:D009101 Multiple Myeloma trichostatin A 17.7518172295
MESH:D009101 Multiple Myeloma zoledronic acid 17.7519621390 16996129 18089719
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4116882708 19157545 18608210 19010910
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.947678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.163581430
MESH:D009362 Neoplasm Metastasis zoledronic acid 6.1617312309 19139120 15867366
MESH:D009369 Neoplasms Cyclophosphamide 5.5418854779
MESH:D009369 Neoplasms decitabine 5.5417925555 19116145 19470736
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.956679447
MESH:D009447 Neuroblastoma Cyclophosphamide 3.6616115947 15176712 8761367
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.978761367 12837982
MESH:D009503 Neutropenia Cyclophosphamide 4.388291058
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.0516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.056482804 4026338
MESH:D009845 Oligospermia Cyclophosphamide 4.7916517039
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010014 Osteolysis zoledronic acid 5.4515867366
MESH:D010024 Osteoporosis zoledronic acid 4.0617882678
MESH:D010051 Ovarian Neoplasms decitabine 5.3219331143 19259094
MESH:D010051 Ovarian Neoplasms trichostatin A 5.3219331143
MESH:D010146 Pain Cyclophosphamide 7.5718093676 12161096
MESH:D010146 Pain zoledronic acid 7.5716475674
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 8.9711332152
MESH:D010190 Pancreatic Neoplasms decitabine 8.9719294695
MESH:D010190 Pancreatic Neoplasms trichostatin A 8.9719294695
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.8321297632
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.9818220299 18042343 19015723
MESH:D055728 Primary Myelofibrosis decitabine 12.6717616702
MESH:D055728 Primary Myelofibrosis trichostatin A 12.6717616702
MESH:D011469 Prostatic Diseases vinclozolin 5.0218220299
MESH:D011471 Prostatic Neoplasms marker/mechanism 19396168 17173048 18798265
MESH:D011471 Prostatic Neoplasms Androgens 2.2616998812 15389811 17909013
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.2617136230
MESH:D011471 Prostatic Neoplasms trichostatin A 2.2619789329 18798265
MESH:D011471 Prostatic Neoplasms zoledronic acid 2.2612438248 19103299
MESH:D011472 Prostatitis vinclozolin 5.0218629315
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3016636934
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.6918410779
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.4619155313
MESH:D012512 Sarcoma, Ewing's zoledronic acid 5.0016121404
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.8816636934
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5718551238
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 3.5518590791
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.6016517039
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.1412837982
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.386587162 6582329 1399818 7505956 3712494
MESH:D013964 Thyroid Neoplasms decitabine 7.3817967635
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 16.0616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 16.068074119
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 16.0614692829
MESH:D001749 Urinary Bladder Neoplasms decitabine 16.0619087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 16.0612846360
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4010091137
MESH:D014604 Uveal Neoplasms decitabine 5.0117785578
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27858
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved