Annotation Detail for ESR1
Basic Information Top
| Gene Symbol: | ESR1 ( DKFZp686N23123,ER,ESR,ESRA,Era,NR3A1 ) |
|---|---|
| Gene Full Name: | estrogen receptor 1 |
| Band: | 6q25.1-q25.2 |
| Quick Links | Entrez ID:2099; OMIM: 133430; Uniprot ID:ESR1_HUMAN; ENSEMBL ID: ENSG00000091831; HGNC ID: 3467 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| Gene Expression |
| Pathway ID | Pathway Name |
|---|---|
| 200002 | Regulation of nuclear SMAD2/3 signaling |
| 200154 | Signaling mediated by p38-alpha and p38-beta |
| 200019 | Signaling events mediated by HDAC Class II |
| 200120 | FOXM1 transcription factor network |
| 200061 | LKB1 signaling events |
| 200072 | Regulation of Telomerase |
| 200118 | AP-1 transcription factor network |
| 200116 | ATF-2 transcription factor network |
| 200029 | Plasma membrane estrogen receptor signaling |
| No data |
| No data |
| No data |
| Desease ID | Desease Name |
|---|---|
| 1708 | Bronchial hyperreactivity |
| 1709 | Parkinson disease |
| 1740 | Alzheimer's disease |
| 1743 | Late pregnancy |
| 1800 | Lupus vulgaris |
| 1836 | Panic disorder |
| 1850 | Herpes |
| 1856 | Obesity |
| 1868 | Thymoma |
| 1881 | Uterine disease |
| 1888 | Myasthenia Gravis |
| 1901 | Endometriosis |
| 1902 | Kidney failure |
| 1904 | Diabetes mellitus |
| 1907 | Depression |
| 1909 | Migraine |
| 1914 | Cerebrovascular disorder |
| 1918 | Atherosclerosis |
| 1934 | Cancer |
| 1940 | Ovarian disease |
| 1954 | Stroke |
| 1964 | Primary biliary cirrhosis |
| 2025 | Polyarthritis |
| 1983 | Down syndrome |
| 1997 | Dental plaque |
| 2091 | Hypertension |
| 2045 | Bipolar disorder |
| 2060 | Glaucoma |
| 2069 | Schizophrenia |
| 2070 | Cholelithiasis |
| 1823 | Infertility, Male |
| 2097 | Hyperlipidemia |
| 2120 | Rabies |
| 2121 | Ovarian failure |
| 2123 | Vitiligo |
| 2138 | Osteoporosis |
| 2146 | Lupus erythematosus |
| 2152 | Renal tubular acidosis |
| 2208 | Synovitis |
| 2241 | Infertility |
| Desease Name |
|---|
| bone density fractures, vertebral |
| rheumatoid arthritis |
| ovarian cancer |
| neuroticism |
| cognitive function |
| cardiovascular disease |
| endothelial-dependent vasolidation |
| Bone mineral density (spine) |
| Scoliosis |
| blood pressure, arterial |
| CARDIOVASCULAR |
| Coronary Artery Disease |
| Diabetes Mellitus |
| osteoporotic fractures but polymorphisms |
| endometriosis |
| Osteoporosis |
| CHEMDEPENDENCY |
| Alzheimer's disease |
| bone mass |
| ovulatory dysfunctions |
| Bone Mineral Density |
| CANCER |
| PSYCH |
| age of menarche |
| Osteoporosis, Postmenopausal |
| PHARMACOGENOMIC |
| bone density |
| endometrial cancer |
| idiopathic azoospermia |
| endometriosis adenomyosis and leiomyomata. |
| spondylosis, lumbar |
| Endometrial Neoplasms |
| breast cancer |
| overall effect |
| Bone mineral density (hip) |
| in vitro fertilization |
| dry eye syndrome |
| lipid and apolipoprotein levels |
| IMMUNE |
| NEUROLOGICAL |
| male infertility |
| varicose ulcers |
| methamphetamine induced psychosis |
| alcohol dependence |
| prostate carcinoma |
| Obesity, Morbid |
| METABOLIC |
| Infertility, Male |
| serum low-density lipoprotein metabolism |
| Myocardial Infarction |
| acute myocardial infarction |
| osteopenia osteoporosis |
| urolithiasis |
| DEVELOPMENTAL |
| radiographic osteoarthritis of the knee |
| skeletal responsiveness to estrogen |
| body fat distribution |
| quantitative calcaneal ultrasounds |
| REPRODUCTION |
| psychoses |
| calcium excretion |
| Uterine Prolapse |
| Carcinoma, Endometrioid |
| Desease Name |
|---|
| Height |
| Bone mineral density (hip) |
| Breast cancer |
| Bone mineral density (spine) |
| Alcohol dependence |
| Desease Name |
|---|
| Migraine, susceptibility to |
| Atherosclerosis, susceptibility to |
| Myocardial infarction, susceptibility to |
| HDL response to hormone replacement, augmented |
| Breast cancer |
| Estrogen resistance |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C003600 | 11-ketotestosterone | 11-ketotestosterone binds to ESR1 protein | affects binding | 11944962 |
| C003600 | 11-ketotestosterone | 11-ketotestosterone binds to ESR1 protein | affects binding | 11944962 |
| C419153 | 1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole | 1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 17088409 |
| C524478 | 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole | 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [exemestane binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 18677558 |
| C524478 | 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole | 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 20419096 |
| C524478 | 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole | 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [fulvestrant binds to and results in decreased activity of ESR1 protein] | affects binding|decreases activity|decreases reaction | 20419096 |
| C042146 | 1,3-dichlorobenzene | 1,3-dichlorobenzene results in increased activity of ESR1 protein | increases activity | 12558164 |
| C496950 | 1-(4-(octahydropyrido(1,2-a)pyrazin-2-yl)phenyl)-2-phenyl-1,2,3,4-tetrahydroisoquinolin-6-ol | 1-(4-(octahydropyrido(1,2-a)pyrazin-2-yl)phenyl)-2-phenyl-1,2,3,4-tetrahydroisoquinolin-6-ol binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 15658851 |
| C034554 | 16 alpha-bromo-17 beta-estradiol | 16 alpha-bromo-17 beta-estradiol binds to ESR1 protein | affects binding | 9751507 |
| C034554 | 16 alpha-bromo-17 beta-estradiol | 16 alpha-bromo-17 beta-estradiol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9751507 |
| C024871 | 16 alpha-iodoestradiol | 16 alpha-iodoestradiol binds to and affects the activity of ESR1 protein | affects activity|affects binding | 12950458 |
| C002029 | 17alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol | 17alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12206426 |
| C033729 | 1H,1H,2H,2H-perfluorodecanol | 1H,1H,2H,2H-perfluorodecanol promotes the reaction [ESR1 protein binds to NCOA2 protein] | affects binding|increases reaction | 17603182 |
| C033729 | 1H,1H,2H,2H-perfluorodecanol | 1H,1H,2H,2H-perfluorodecanol results in increased activity of ESR1 protein | increases activity | 17603182 |
| C033729 | 1H,1H,2H,2H-perfluorodecanol | 1H,1H,2H,2H-perfluorodecanol results in increased expression of ESR1 mRNA | increases expression | 16393665 |
| C508406 | 1H,1H,2H,2H-perfluorooctan-1-ol | 1H,1H,2H,2H-perfluorooctan-1-ol promotes the reaction [ESR1 protein binds to NCOA2 protein] | affects binding|increases reaction | 17603182 |
| C508406 | 1H,1H,2H,2H-perfluorooctan-1-ol | 1H,1H,2H,2H-perfluorooctan-1-ol results in increased activity of ESR1 protein | increases activity | 17603182 |
| C508406 | 1H,1H,2H,2H-perfluorooctan-1-ol | 1H,1H,2H,2H-perfluorooctan-1-ol results in increased expression of ESR1 mRNA | increases expression | 16393665 |
| C548651 | 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester | 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ESR1 mRNA | decreases expression | 19933214 |
| C054919 | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| C054919 | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene binds to ESR1 protein | affects binding | 14579009 |
| C054919 | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| C054919 | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| C054919 | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12206426 |
| C054919 | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene binds to ESR1 protein | affects binding | 11162928 |
| C035476 | 2,2',4,4'-tetrahydroxybenzophenone | 2,2',4,4'-tetrahydroxybenzophenone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16079615 12765246 |
| C035476 | 2,2',4,4'-tetrahydroxybenzophenone | 2,2',4,4'-tetrahydroxybenzophenone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15458795 |
| C035476 | 2,2',4,4'-tetrahydroxybenzophenone | 2,2',4,4'-tetrahydroxybenzophenone results in decreased expression of ESR1 mRNA | decreases expression | 15458797 |
| C035476 | 2,2',4,4'-tetrahydroxybenzophenone | 2,2',4,4'-tetrahydroxybenzophenone results in increased activity of ESR1 protein | increases activity | 12504345 |
| C035476 | 2,2',4,4'-tetrahydroxybenzophenone | 2,2',4,4'-tetrahydroxybenzophenone results in increased expression of ESR1 mRNA | increases expression | 15458795 |
| C404910 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane binds to ESR1 protein | affects binding | 11162928 |
| C404910 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane binds to ESR1 protein | affects binding | 11162928 |
| C404910 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 10579340 11530281 10999957 15840436 10774817 |
| C404910 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane binds to ESR1 protein | affects binding | 11162928 |
| C404910 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [Genistein binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 11861976 |
| C404910 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Genistein binds to and results in increased activity of ESR1 protein] | affects binding|increases activity|increases reaction | 11861976 |
| C404910 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane binds to ESR1 protein | affects binding | 11162928 |
| C404910 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased expression of ESR1 mRNA | decreases expression | 11509743 |
| C404910 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane | ESR1 protein promotes the reaction [2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased phosphorylation of and results in increased activity of IGF1R protein] | increases activity|increases phosphorylation|increases reaction | 10965916 |
| C404910 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane | [Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of ESR1 mRNA | affects cotreatment|decreases expression | 11509743 |
| C404910 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane binds to ESR1 protein | affects binding | 11162928 |
| C404910 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 10579340 |
| C404910 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 11509743 |
| C404910 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane binds to ESR1 protein | affects binding | 14664857 |
| C002462 | 2,2-di(4-methacryloxyphenyl)propane | [Bisphenol A-Glycidyl Methacrylate co-treated with 2,2-di(4-methacryloxyphenyl)propane co-treated with triethylene glycol dimethacrylate] results in increased activity of ESR1 protein | affects cotreatment|increases activity | 11145352 |
| C003585 | 22-hydroxycholesterol | 22-hydroxycholesterol binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 17873880 |
| C003585 | 22-hydroxycholesterol | 22-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17873880 |
| C087667 | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl binds to ESR1 protein | affects binding | 16293362 |
| C104006 | 2',3',4',5'-tetrachloro-4-biphenylol | 2',3',4',5'-tetrachloro-4-biphenylol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 11530281 |
| C104006 | 2',3',4',5'-tetrachloro-4-biphenylol | 2',3',4',5'-tetrachloro-4-biphenylol binds to ESR1 protein | affects binding | 10964929 |
| C104006 | 2',3',4',5'-tetrachloro-4-biphenylol | 2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 10964929 |
| C101851 | 2-(((3,5-dichlorophenyl)carbamoyl)oxy)-2-methyl-3-butenoic acid | 2-(((3,5-dichlorophenyl)carbamoyl)oxy)-2-methyl-3-butenoic acid binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16750840 |
| C486182 | 2,3-bis(4-hydroxyphenyl)-propionitrile | ESR1 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of BCL2 protein] | affects reaction|increases expression | 19264808 |
| C486182 | 2,3-bis(4-hydroxyphenyl)-propionitrile | ESR1 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PDCD4 protein] | affects reaction|increases expression | 19264808 |
| C486182 | 2,3-bis(4-hydroxyphenyl)-propionitrile | ESR1 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PTEN protein] | affects reaction|increases expression | 19264808 |
| C014024 | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl binds to ESR1 protein | affects binding | 16293362 |
| C067259 | 2,4,6-trichlorophenyl-4'-aminophenyl ether | 2,4,6-trichlorophenyl-4'-aminophenyl ether binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12676605 |
| C067259 | 2,4,6-trichlorophenyl-4'-aminophenyl ether | 2,4,6-trichlorophenyl-4'-aminophenyl ether binds to ESR1 protein | affects binding | 12676605 |
| C067259 | 2,4,6-trichlorophenyl-4'-aminophenyl ether | 2,4,6-trichlorophenyl-4'-aminophenyl ether results in increased activity of ESR1 protein | increases activity | 15064155 |
| C010422 | 2,4,6-trichlorophenyl 4-nitrophenyl ether | 2,4,6-trichlorophenyl 4-nitrophenyl ether binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12676605 |
| C010422 | 2,4,6-trichlorophenyl 4-nitrophenyl ether | 2,4,6-trichlorophenyl 4-nitrophenyl ether binds to ESR1 protein | affects binding | 12676605 |
| C010422 | 2,4,6-trichlorophenyl 4-nitrophenyl ether | 2,4,6-trichlorophenyl 4-nitrophenyl ether results in increased activity of ESR1 protein | increases activity | 15064155 |
| C121479 | 2,4-dihydroxybenzophenone | 2,4-dihydroxybenzophenone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16079615 |
| C044563 | 24-hydroxycholesterol | 24-hydroxycholesterol binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 17873880 |
| C044563 | 24-hydroxycholesterol | 24-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17873880 |
| C439584 | 2-(4-hydroxyphenyl)-3-methyl-1-(4-(2-piperidin-1-yl-ethoxy)-benzyl)-1H-indol-5-ol | 2-(4-hydroxyphenyl)-3-methyl-1-(4-(2-piperidin-1-yl-ethoxy)-benzyl)-1H-indol-5-ol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ESR1 protein | decreases activity|decreases expression|decreases phosphorylation | 16954435 |
| C085911 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein affects the localization of ESR1 protein] | affects localization|decreases reaction | 15947004 |
| C085911 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[KGF protein results in increased phosphorylation of AKT1 protein] which results in increased expression of ESR1 protein] | decreases reaction|increases expression|increases phosphorylation | 19661335 |
| C007997 | 25-hydroxycholesterol | 25-hydroxycholesterol binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 17873880 |
| C007997 | 25-hydroxycholesterol | 25-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17873880 |
| C076996 | 27-hydroxycholesterol | 27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR1 protein | affects binding|affects folding|increases activity | 17872378 |
| C076996 | 27-hydroxycholesterol | 27-hydroxycholesterol binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 17873880 |
| C076996 | 27-hydroxycholesterol | 27-hydroxycholesterol inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 17872378 |
| C076996 | 27-hydroxycholesterol | 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17873880 |
| C076996 | 27-hydroxycholesterol | 27-hydroxycholesterol promotes the reaction [ESR1 protein binds to TFF1 promoter] | affects binding|increases reaction | 17872378 |
| C076996 | 27-hydroxycholesterol | 27-hydroxycholesterol results in increased degradation of ESR1 protein | increases degradation | 17872378 |
| C076996 | 27-hydroxycholesterol | fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17872378 |
| C076996 | 27-hydroxycholesterol | ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA] | affects reaction|decreases expression | 17873880 |
| C076996 | 27-hydroxycholesterol | ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA] | affects reaction|decreases expression | 17873880 |
| C076996 | 27-hydroxycholesterol | ESR1 protein affects the susceptibility to 27-hydroxycholesterol | affects response to substance | 17873880 |
| C496953 | 2-ethyl-4-(4-hydroxyphenyl)-5-(4-(2-piperidin-1-ylethoxy)phenyl)-2-imidazoline | 2-ethyl-4-(4-hydroxyphenyl)-5-(4-(2-piperidin-1-ylethoxy)phenyl)-2-imidazoline inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 15658860 |
| C024980 | 2-hydroxyestrone | 2-hydroxyestrone binds to ESR1 protein | affects binding | 16728493 |
| C024980 | 2-hydroxyestrone | 2-hydroxyestrone binds to ESR1 protein | affects binding | 15001543 |
| C004369 | 2-phenylphenol | 2-phenylphenol results in decreased expression of ESR1 mRNA | decreases expression | 12822488 |
| C004369 | 2-phenylphenol | 2-phenylphenol results in increased expression of ESR1 mRNA | increases expression | 12737316 |
| C041525 | 3,3',4,5'-tetrahydroxystilbene | 3,3',4,5'-tetrahydroxystilbene binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15120416 |
| C016392 | 3,3'-diindolylmethane | 3,3'-diindolylmethane binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16972788 |
| C016392 | 3,3'-diindolylmethane | 3,3'-diindolylmethane promotes the reaction [ESR1 protein binds to CYP1A1 promoter] | affects binding|increases reaction | 16972788 |
| C016392 | 3,3'-diindolylmethane | 3,3'-diindolylmethane promotes the reaction [ESR1 protein binds to TFF1 promoter] | affects binding|increases reaction | 16972788 |
| C016392 | 3,3'-diindolylmethane | 3,3'-diindolylmethane results in decreased expression of ESR1 | decreases expression | 19223575 |
| C087550 | 3-(4-(1,2-diphenylbut-1-enyl)phenyl)acrylic acid | 3-(4-(1,2-diphenylbut-1-enyl)phenyl)acrylic acid binds to and affects the folding of and results in decreased stability of and results in decreased activity of ESR1 protein | affects binding|affects folding|decreases activity|decreases stability | 15893725 |
| C087550 | 3-(4-(1,2-diphenylbut-1-enyl)phenyl)acrylic acid | 3-(4-(1,2-diphenylbut-1-enyl)phenyl)acrylic acid results in increased degradation of ESR1 protein | increases degradation | 19477949 |
| C028451 | 3,4,3',4'-tetrachlorobiphenyl | 3,4,3',4'-tetrachlorobiphenyl binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16972788 |
| C028451 | 3,4,3',4'-tetrachlorobiphenyl | 3,4,3',4'-tetrachlorobiphenyl binds to ESR1 protein | affects binding | 16293362 |
| C028451 | 3,4,3',4'-tetrachlorobiphenyl | 3,4,3',4'-tetrachlorobiphenyl promotes the reaction [ESR1 protein binds to CYP1A1 promoter] | affects binding|increases reaction | 16972788 |
| C028451 | 3,4,3',4'-tetrachlorobiphenyl | 3,4,3',4'-tetrachlorobiphenyl promotes the reaction [ESR1 protein binds to TFF1 promoter] | affects binding|increases reaction | 16972788 |
| C028451 | 3,4,3',4'-tetrachlorobiphenyl | 3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [nonylphenol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 16291559 |
| C028451 | 3,4,3',4'-tetrachlorobiphenyl | [4-nonylphenol co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 17291011 |
| C028451 | 3,4,3',4'-tetrachlorobiphenyl | alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 17291011 |
| C023035 | 3,4,5,3',4'-pentachlorobiphenyl | 3,4,5,3',4'-pentachlorobiphenyl binds to ESR1 protein | affects binding | 16489053 |
| C023035 | 3,4,5,3',4'-pentachlorobiphenyl | 3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [ESR1 protein binds to CYP1A1 promoter] | affects binding|increases reaction | 16489053 |
| C023035 | 3,4,5,3',4'-pentachlorobiphenyl | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ESR1 mRNA | increases expression | 16489053 |
| C023035 | 3,4,5,3',4'-pentachlorobiphenyl | fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 16489053 |
| C548780 | 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide | 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide binds to ESR1 protein | affects binding | 20861237 |
| C548780 | 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide | 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 20861237 |
| C548780 | 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide | 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide results in decreased activity of ESR1 protein | decreases activity | 20861237 |
| C053286 | 3,4-dihydroxybenzaldoxime | 3,4-dihydroxybenzaldoxime analog binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12954056 |
| C038939 | 3-(4'-methylbenzylidene)camphor | 3-(4'-methylbenzylidene)camphor binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16079615 |
| C101850 | 3',5'-dichloro-2-hydroxy-2-methylbut-3-enanilide | 3',5'-dichloro-2-hydroxy-2-methylbut-3-enanilide binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16750840 |
| C439024 | 3,5-dihydroxy-4'-methoxystilbene | 3,5-dihydroxy-4'-methoxystilbene results in increased expression of ESR1 mRNA | increases expression | 15820104 |
| C026423 | 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one | 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one binds to and affects the activity of ESR1 protein | affects activity|affects binding | 16506809 |
| C047368 | 3-methylquercetin | 3-methylquercetin binds to ESR1 protein | affects binding | 14706564 |
| C064808 | 3-phenoxybenzaldehyde | 3-phenoxybenzaldehyde binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16395479 |
| C064809 | 3-phenoxybenzylalcohol | 3-phenoxybenzylalcohol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16395479 |
| C432591 | 4-(1-adamantyl)phenol | 4-(1-adamantyl)phenol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 19666091 |
| C432591 | 4-(1-adamantyl)phenol | 4-(1-adamantyl)phenol results in increased expression of ESR1 mRNA | increases expression | 15820104 |
| C432591 | 4-(1-adamantyl)phenol | 4-(1-adamantyl)phenol results in increased activity of ESR1 protein | increases activity | 12504345 |
| C496751 | 4-(1H-imidazol-1-yl)retinoic acid | 4-(1H-imidazol-1-yl)retinoic acid results in decreased expression of ESR1 protein | decreases expression | 17145897 |
| C496751 | 4-(1H-imidazol-1-yl)retinoic acid | 4-(1H-imidazol-1-yl)retinoic acid results in increased expression of ESR1 protein | increases expression | 17387344 |
| C496751 | 4-(1H-imidazol-1-yl)retinoic acid | 4-(1H-imidazol-1-yl)retinoic acid results in decreased expression of ESR1 protein | decreases expression | 17145897 |
| C496952 | 4-(2-chloro-4-(2-piperidin-1-ylethoxy)phenyl)-5-(2,6-dichloro-4-hydroxyphenyl)-2-imidazoline | 4-(2-chloro-4-(2-piperidin-1-ylethoxy)phenyl)-5-(2,6-dichloro-4-hydroxyphenyl)-2-imidazoline binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15658860 |
| C486184 | 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol | 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 17234159 20926581 15994857 |
| C445860 | 4,4'-bis(2-sulfostyryl)biphenyl | 4,4'-bis(2-sulfostyryl)biphenyl binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 18348622 |
| C027439 | 4,4'-dihydroxybiphenyl | 4,4'-dihydroxybiphenyl binds to ESR1 protein | affects binding | 12753421 |
| C008745 | 4,4'-methylenebis(phenol) | 4,4'-methylenebis(phenol) binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15110108 |
| C516284 | 4-cumylphenol | 4-cumylphenol results in increased activity of ESR1 protein | increases activity | 12504345 11750080 |
| C077547 | 4-cyclododecyl-2,6-dimethylmorpholine acetate | 4-cyclododecyl-2,6-dimethylmorpholine acetate binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9460653 |
| C018511 | 4-dichlorobenzene | 4-dichlorobenzene results in increased activity of ESR1 protein | increases activity | 12558164 |
| C477728 | 4-fluorobenzoyl-TN-14003 | 4-fluorobenzoyl-TN-14003 inhibits the reaction [SDF1 protein results in increased activity of ESR1 protein] | decreases reaction|increases activity | 19584281 |
| C524594 | 4-hydroxyazobenzene | 4-hydroxyazobenzene results in increased activity of ESR1 protein | increases activity | 12504345 |
| C024292 | 4-hydroxybenzophenone | 4-hydroxybenzophenone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12765246 16079615 |
| C024292 | 4-hydroxybenzophenone | 4-hydroxybenzophenone results in increased activity of ESR1 protein | increases activity | 12504345 |
| C050622 | 4-hydroxyclomiphene | 4-hydroxyclomiphene binds to ESR1 protein | affects binding | 15521089 |
| C065250 | 4-hydroxy-equilenin | 4-hydroxy-equilenin results in increased activity of ESR1 protein | increases activity | 19158089 |
| C065250 | 4-hydroxy-equilenin | ESR1 protein results in increased susceptibility to 4-hydroxy-equilenin | increases response to substance | 19158089 |
| C014036 | 4-hydroxyestradiol-17 beta | 4-hydroxyestradiol-17 beta binds to ESR1 protein | affects binding | 15993745 |
| C055492 | 4-hydroxy-N-desmethyltamoxifen | 4-hydroxy-N-desmethyltamoxifen inhibits the reaction [[Tamoxifen co-treated with N-desmethyltamoxifen co-treated with 4-hydroxytamoxifen] results in increased stability of ESR1 protein] | affects cotreatment|decreases reaction|increases stability | 19244106 |
| C055492 | 4-hydroxy-N-desmethyltamoxifen | 4-hydroxy-N-desmethyltamoxifen results in decreased expression of ESR1 mRNA | decreases expression | 19244106 |
| C055492 | 4-hydroxy-N-desmethyltamoxifen | 4-hydroxy-N-desmethyltamoxifen results in decreased expression of ESR1 protein | decreases expression | 19244106 |
| C055492 | 4-hydroxy-N-desmethyltamoxifen | 4-hydroxy-N-desmethyltamoxifen results in increased degradation of ESR1 protein | increases degradation | 19244106 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen binds to ESR1 protein | affects binding | 11162928 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen binds to ESR1 protein | affects binding | 11162928 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxy-N-desmethyltamoxifen inhibits the reaction [[Tamoxifen co-treated with N-desmethyltamoxifen co-treated with 4-hydroxytamoxifen] results in increased stability of ESR1 protein] | affects cotreatment|decreases reaction|increases stability | 19244106 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 12765246 17049190 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 11530281 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen binds to ESR1 protein | affects binding | 17400923 11162928 15521089 9751507 16037132 17203231 10397250 |
| C016601 | 4-hydroxytamoxifen | [4-hydroxytamoxifen binds to ESR1 protein] which binds to TFF1 protein | affects binding | 14617632 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen inhibits the reaction [bisphenol A results in increased activity of ESR1 protein] | decreases reaction|increases activity | 14754635 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen inhibits the reaction [ESR1 protein binds to STUB1 protein] | affects binding|decreases reaction | 16037132 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9751507 11751013 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 15885261 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen inhibits the reaction [nonylphenol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 14754635 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]] | affects binding|decreases reaction|increases reaction | 19460354 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]] | affects binding|decreases reaction|increases reaction | 19460354 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen promotes the reaction [ESR1 protein binds to CDH1 promoter] | affects binding|increases reaction | 19593637 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen promotes the reaction [ESR1 protein binds to TFF1 promoter] | affects binding|increases reaction | 19858209 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen results in decreased activity of ESR1 protein | decreases activity | 9846162 14754635 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen results in increased expression of ESR1 protein | increases expression | 19244106 |
| C016601 | 4-hydroxytamoxifen | ARID5A protein inhibits the reaction [4-hydroxytamoxifen results in increased activity of ESR1 protein] | decreases reaction|increases activity | 15941852 |
| C016601 | 4-hydroxytamoxifen | ESR1 protein promotes the reaction [4-hydroxytamoxifen results in increased expression of SERPINB9 mRNA] | increases expression|increases reaction | 17237823 |
| C016601 | 4-hydroxytamoxifen | [lapatinib co-treated with 4-hydroxytamoxifen] results in decreased activity of ESR1 protein | affects cotreatment|decreases activity | 15665275 |
| C016601 | 4-hydroxytamoxifen | [methylselenic acid co-treated with 4-hydroxytamoxifen] results in decreased expression of ESR1 mRNA | affects cotreatment|decreases expression | 16093440 |
| C016601 | 4-hydroxytamoxifen | [methylselenic acid co-treated with 4-hydroxytamoxifen] results in decreased expression of ESR1 protein | affects cotreatment|decreases expression | 16093440 |
| C016601 | 4-hydroxytamoxifen | Plicamycin inhibits the reaction [4-hydroxytamoxifen promotes the reaction [ESR1 protein binds to CDH1 promoter]] | affects binding|decreases reaction|increases reaction | 19593637 |
| C016601 | 4-hydroxytamoxifen | [Tamoxifen co-treated with N-desmethyltamoxifen co-treated with 4-hydroxytamoxifen] results in increased stability of ESR1 protein | affects cotreatment|increases stability | 19244106 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen binds to ESR1 protein | affects binding | 15001543 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen binds to ESR1 protein | affects binding | 11162928 15161930 |
| C016601 | 4-hydroxytamoxifen | ESR1 protein promotes the reaction [4-hydroxytamoxifen results in increased phosphorylation of and results in increased activity of IGF1R protein] | increases activity|increases phosphorylation|increases reaction | 10965916 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen binds to ESR1 protein | affects binding | 11162928 11944962 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen inhibits the reaction [Chlordecone results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 8800639 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen inhibits the reaction [Lindane results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 8800639 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen inhibits the reaction [nonylphenol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 8800639 |
| C016601 | 4-hydroxytamoxifen | 4-hydroxytamoxifen binds to ESR1 protein | affects binding | 11944962 |
| C041594 | 4-nonylphenol | 4-nonylphenol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 11530281 |
| C041594 | 4-nonylphenol | 4-nonylphenol binds to ESR1 protein | affects binding | 11518614 |
| C041594 | 4-nonylphenol | 4-nonylphenol results in decreased expression of ESR1 mRNA | decreases expression | 16393665 |
| C041594 | 4-nonylphenol | 4-nonylphenol results in increased activity of ESR1 protein mutant form | increases activity | 17141713 |
| C041594 | 4-nonylphenol | 4-nonylphenol binds to ESR1 protein | affects binding | 15081833 |
| C041594 | 4-nonylphenol | 4-nonylphenol results in decreased expression of ESR1 mRNA | decreases expression | 16759644 |
| C041594 | 4-nonylphenol | 4-nonylphenol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12206426 |
| C041594 | 4-nonylphenol | 4-nonylphenol binds to ESR1 protein | affects binding | 11944962 |
| C041594 | 4-nonylphenol | 4-nonylphenol results in increased activity of ESR1 protein | increases activity | 17174995 |
| C041594 | 4-nonylphenol | 4-nonylphenol binds to ESR1 protein | affects binding | 11944962 |
| C041594 | 4-nonylphenol | [4-nonylphenol co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 17291011 |
| C041594 | 4-nonylphenol | 4-nonylphenol promotes the reaction [ESR1 protein binds to ESR1 protein] | affects binding|increases reaction | 15891078 |
| C041594 | 4-nonylphenol | 4-nonylphenol results in increased expression of ESR1 mRNA | increases expression | 17291011 |
| C041594 | 4-nonylphenol | fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 17291011 |
| C041594 | 4-nonylphenol | Tamoxifen inhibits the reaction [4-nonylphenol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 17291011 |
| C041594 | 4-nonylphenol | 4-nonylphenol results in increased expression of ESR1 mRNA | increases expression | 17258427 |
| C041594 | 4-nonylphenol | 4-nonylphenol results in increased expression of ESR1 mRNA | increases expression | 16198636 |
| C041594 | 4-nonylphenol | 4-nonylphenol results in increased activity of ESR1 protein | increases activity | 11403899 |
| C080417 | 4-octylphenol | 4-octylphenol results in increased activity of ESR1 protein | increases activity | 18028983 |
| C080417 | 4-octylphenol | 4-octylphenol binds to ESR1 protein | affects binding | 15081833 |
| C080417 | 4-octylphenol | 4-octylphenol results in increased activity of ESR1 protein | increases activity | 18028983 |
| C019046 | 4-phenylphenol | 4-phenylphenol binds to ESR1 protein | affects binding | 12753421 |
| C019046 | 4-phenylphenol | 4-phenylphenol results in increased activity of ESR1 protein | increases activity | 18028983 |
| C019046 | 4-phenylphenol | 4-phenylphenol results in increased expression of ESR1 mRNA | increases expression | 12737316 |
| C019046 | 4-phenylphenol | 4-phenylphenol results in increased activity of ESR1 protein | increases activity | 18028983 |
| C099327 | 4-propylphenol | 4-propylphenol results in increased activity of ESR1 protein | increases activity | 18028983 |
| C099327 | 4-propylphenol | 4-propylphenol results in increased activity of ESR1 protein | increases activity | 18028983 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol binds to ESR1 protein | affects binding | 11162928 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol results in increased activity of ESR1 protein | increases activity | 18980245 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol binds to ESR1 protein | affects binding | 11162928 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 11530281 19666091 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol binds to ESR1 protein | affects binding | 11162928 10964929 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 10964929 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol promotes the reaction [ESR1 protein binds to NCOA1 protein] | affects binding|increases reaction | 10964929 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol promotes the reaction [ESR1 protein binds to NCOA2 protein] | affects binding|increases reaction | 10964929 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol results in increased activity of ESR1 protein mutant form | increases activity | 17141713 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol results in increased expression of ESR1 mRNA | increases expression | 12737316 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol binds to ESR1 protein | affects binding | 11162928 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12206426 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol binds to ESR1 protein | affects binding | 11162928 11944962 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol binds to ESR1 protein | affects binding | 11086226 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol results in increased activity of ESR1 protein | increases activity | 12504345 11750080 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol binds to ESR1 protein | affects binding | 11944962 |
| C105260 | 4-tert-octylphenol | 4-tert-octylphenol results in increased expression of ESR1 mRNA | increases expression | 17258427 |
| C120076 | 5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol | 5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15465114 |
| C113977 | 5-octylphenol | 5-octylphenol binds to ESR1 protein | affects binding | 11518614 |
| C462031 | 6-(1,1-dimethylallyl)naringenin | [6-(1,1-dimethylallyl)naringenin binds to ESR1 protein] which results in increased activity of ALPL protein | affects binding|increases activity | 12650720 |
| C462031 | 6-(1,1-dimethylallyl)naringenin | fulvestrant inhibits the reaction [[6-(1,1-dimethylallyl)naringenin binds to ESR1 protein] which results in increased activity of ALPL protein] | affects binding|decreases reaction|increases activity | 12650720 |
| C027880 | 6-deisopropylatrazine | 6-deisopropylatrazine binds to ESR1 protein | affects binding | 8858116 |
| C027880 | 6-deisopropylatrazine | 6-deisopropylatrazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 8858116 |
| C054923 | 6-methyl-1,3,8-trichlorodibenzofuran | 6-methyl-1,3,8-trichlorodibenzofuran binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16972788 |
| C054923 | 6-methyl-1,3,8-trichlorodibenzofuran | 6-methyl-1,3,8-trichlorodibenzofuran promotes the reaction [ESR1 protein binds to CYP1A1 promoter] | affects binding|increases reaction | 16972788 |
| C054923 | 6-methyl-1,3,8-trichlorodibenzofuran | 6-methyl-1,3,8-trichlorodibenzofuran promotes the reaction [ESR1 protein binds to TFF1 promoter] | affects binding|increases reaction | 16972788 |
| C121707 | 7,3'-dihydroxy-4'-methoxyisoflavone | 7,3'-dihydroxy-4'-methoxyisoflavone binds to ESR1 protein | affects binding | 20686605 |
| C121707 | 7,3'-dihydroxy-4'-methoxyisoflavone | 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 20686605 |
| C475050 | 7alpha-methyl-17alpha-ethynylestradiol | 7alpha-methyl-17alpha-ethynylestradiol binds to ESR1 protein | affects binding | 12117614 |
| C119737 | 8-prenylnaringenin | 8-prenylnaringenin analog binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 17149865 |
| C119737 | 8-prenylnaringenin | 8-prenylnaringenin binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15876408 16076101 |
| C119737 | 8-prenylnaringenin | [8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein | affects binding|increases activity | 12650720 |
| C119737 | 8-prenylnaringenin | 8-prenylnaringenin results in increased activity of ESR1 protein | increases activity | 12623674 |
| C119737 | 8-prenylnaringenin | fulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein] | affects binding|decreases reaction|increases activity | 12650720 |
| D000082 | Acetaminophen | Acetaminophen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to ESR1 protein]] | affects binding|decreases reaction|increases reaction | 15713566 |
| D000082 | Acetaminophen | Acetaminophen affects the expression of ESR1 mRNA | affects expression | 17562736 |
| D000109 | Acetylcholine | ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Acetylcholine] | affects cotreatment|affects response to substance | 17158209 |
| D000109 | Acetylcholine | ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Acetylcholine] | affects cotreatment|affects response to substance | 17158209 |
| D000242 | Cyclic AMP | CARM1 protein promotes the reaction [Cyclic AMP results in increased activity of ESR1 protein] | increases activity|increases reaction | 20360387 |
| D000242 | Cyclic AMP | CREBBP protein promotes the reaction [Cyclic AMP results in increased activity of ESR1 protein] | increases activity|increases reaction | 20360387 |
| D000242 | Cyclic AMP | Cyclic AMP promotes the reaction [CARM1 protein binds to ESR1 protein] | affects binding|increases reaction | 20360387 |
| D000242 | Cyclic AMP | Cyclic AMP results in increased activity of ESR1 protein | increases activity | 20360387 |
| D000242 | Cyclic AMP | [Cyclic AMP results in increased phosphorylation of CARM1 protein] promotes the reaction [CARM1 protein binds to ESR1 protein] | affects binding|increases phosphorylation|increases reaction | 20360387 |
| D000242 | Cyclic AMP | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cyclic AMP results in increased activity of ESR1 protein] | decreases reaction|increases activity | 20360387 |
| D000272 | Adipic Acids | Adipic Acids results in increased activity of ESR1 protein | increases activity | 16756374 |
| C412373 | AG 1879 | AG 1879 inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein] | decreases reaction|increases phosphorylation | 15615701 |
| C412373 | AG 1879 | AG 1879 inhibits the reaction [fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]] | affects binding|decreases reaction|increases reaction | 19815064 |
| C412373 | AG 1879 | AG 1879 inhibits the reaction [resveratrol affects the localization of ESR1 protein] | affects localization|decreases reaction | 17513867 |
| C412373 | AG 1879 | AG 1879 inhibits the reaction [resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]] | affects binding|decreases reaction|increases reaction | 17513867 |
| C412373 | AG 1879 | AG 1879 inhibits the reaction [resveratrol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17513867 |
| C412373 | AG 1879 | AG 1879 inhibits the reaction [resveratrol results in increased phosphorylation of ESR1 protein] | decreases reaction|increases phosphorylation | 15615701 |
| C412373 | AG 1879 | [AG 1879 results in decreased activity of SRC protein] which affects the localization of ESR1 protein | affects localization|decreases activity | 19815064 |
| C000188 | alachlor | alachlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| C000188 | alachlor | alachlor binds to ESR1 protein | affects binding | 14579009 |
| C000188 | alachlor | alachlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| C000188 | alachlor | [Dieldrin co-treated with alachlor] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D000448 | Aldicarb | Aldicarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 9126867 |
| D000452 | Aldrin | Aldrin binds to ESR1 protein | affects binding | 14579009 |
| D000452 | Aldrin | Aldrin inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D000452 | Aldrin | Aldrin results in increased activity of ESR1 protein | increases activity | 15064155 |
| C103303 | alitretinoin | alitretinoin inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 19340624 |
| C103303 | alitretinoin | alitretinoin results in decreased expression of ESR1 mRNA | decreases expression | 16051031 |
| C103303 | alitretinoin | Melatonin promotes the reaction [alitretinoin results in decreased expression of ESR1 mRNA] | decreases expression|increases reaction | 16051031 |
| D043582 | 5-alpha-Dihydroprogesterone | 5-alpha-Dihydroprogesterone results in increased expression of ESR1 mRNA | increases expression | 17683929 |
| D013196 | Dihydrotestosterone | Dihydrotestosterone binds to ESR1 protein | affects binding | 11162928 |
| D013196 | Dihydrotestosterone | Dihydrotestosterone binds to ESR1 protein | affects binding | 11162928 |
| D013196 | Dihydrotestosterone | Dihydrotestosterone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12676605 |
| D013196 | Dihydrotestosterone | Dihydrotestosterone binds to ESR1 protein | affects binding | 11162928 |
| D013196 | Dihydrotestosterone | Dihydrotestosterone binds to ESR1 protein | affects binding | 11162928 |
| D013196 | Dihydrotestosterone | Dihydrotestosterone binds to ESR1 protein | affects binding | 11162928 |
| D013196 | Dihydrotestosterone | Dihydrotestosterone results in increased activity of ESR1 protein | increases activity | 11750080 |
| C040534 | alpha-hexachlorocyclohexane | alpha-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 10580743 |
| C011512 | alpha-naphthoflavone | alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 17291011 |
| D005680 | gamma-Aminobutyric Acid | ESR1 protein promotes the reaction [Estradiol inhibits the reaction [Potassium results in increased secretion of gamma-Aminobutyric Acid]] | decreases reaction|increases reaction|increases secretion | 19211896 |
| D015113 | Androstane-3,17-diol | Androstane-3,17-diol analog binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 17003281 |
| D015113 | Androstane-3,17-diol | Androstane-3,17-diol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 17003281 |
| D015113 | Androstane-3,17-diol | fulvestrant inhibits the reaction [Androstane-3,17-diol analog binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 17003281 |
| D015113 | Androstane-3,17-diol | fulvestrant inhibits the reaction [Androstane-3,17-diol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 17003281 |
| D000814 | Aniline Compounds | Aniline Compounds binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12820998 |
| D000814 | Aniline Compounds | Aniline Compounds analog binds to ESR1 protein | affects binding | 19303142 |
| D047310 | Apigenin | Apigenin binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16541309 |
| D047310 | Apigenin | Apigenin binds to ESR1 protein | affects binding | 14579009 |
| D047310 | Apigenin | Apigenin inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D047310 | Apigenin | Apigenin results in decreased expression of ESR1 protein | decreases expression | 16541309 |
| D047310 | Apigenin | Apigenin results in increased activity of ESR1 protein | increases activity | 16860978 16118406 |
| D047310 | Apigenin | Apigenin results in increased phosphorylation of ESR1 protein | increases phosphorylation | 17323972 |
| C032739 | aroclor 1221 | aroclor 1221 binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9460653 |
| C027423 | aroclor 1242 | aroclor 1242 inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| C028617 | aroclor 1248 | aroclor 1248 binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9460653 |
| D001151 | Arsenic | Arsenic results in increased expression of ESR1 mRNA | increases expression | 17306315 |
| D001151 | Arsenic | Arsenic results in decreased methylation of ESR1 promoter | decreases methylation | 15026472 |
| D001151 | Arsenic | Arsenic results in increased expression of ESR1 mRNA | increases expression | 15026472 |
| C006632 | arsenic trioxide | arsenic trioxide results in decreased expression of ESR1 mRNA | decreases expression | 19088370 |
| C006632 | arsenic trioxide | arsenic trioxide results in decreased expression of ESR1 protein | decreases expression | 12014631 19088370 |
| C006632 | arsenic trioxide | arsenic trioxide results in increased expression of ESR1 mRNA | increases expression | 20458559 |
| C006632 | arsenic trioxide | arsenic trioxide results in decreased methylation of ESR1 promoter | decreases methylation | 15073043 |
| C006632 | arsenic trioxide | arsenic trioxide results in increased expression of ESR1 mRNA | increases expression | 15073043 |
| C006632 | arsenic trioxide | arsenic trioxide results in increased expression of ESR1 protein | increases expression | 15073043 |
| C015001 | arsenite | arsenite binds to ESR1 protein | affects binding | 15963345 |
| C015001 | arsenite | arsenite results in increased expression of ESR1 mRNA | increases expression | 18991936 |
| D001280 | Atrazine | Atrazine inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D001280 | Atrazine | Atrazine binds to ESR1 protein | affects binding | 8858116 14579009 |
| D001280 | Atrazine | Atrazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 8858116 |
| D001280 | Atrazine | Atrazine inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D001280 | Atrazine | Atrazine inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 15056801 |
| C447119 | bazedoxifene acetate | bazedoxifene acetate binds to ESR1 protein | affects binding | 15961563 |
| C007725 | bendiocarb | bendiocarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 9126867 |
| D001542 | Benomyl | Benomyl binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16626760 |
| D001542 | Benomyl | Benomyl binds to ESR1 protein | affects binding | 14579009 |
| D001542 | Benomyl | Benomyl inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| C030935 | benz(a)anthracene | benz(a)anthracene promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 12441364 |
| C030935 | benz(a)anthracene | benz(a)anthracene results in increased expression of ESR1 mRNA | increases expression | 11922773 |
| C030935 | benz(a)anthracene | benz(a)anthracene results in increased phosphorylation of ESR1 protein | increases phosphorylation | 12441364 |
| C030935 | benz(a)anthracene | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with chrysene] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 11922773 |
| C030935 | benz(a)anthracene | fulvestrant inhibits the reaction [benz(a)anthracene promotes the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity|increases reaction | 12441364 |
| D001565 | Benzoates | Benzoates results in increased activity of ESR1 protein | increases activity | 16756374 |
| D019324 | beta-Naphthoflavone | [beta-Naphthoflavone co-treated with Tamoxifen] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 19456386 |
| C020225 | benzohydrol | benzohydrol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16079615 |
| C047723 | benzophenone | benzophenone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16079615 |
| D001577 | Benzophenones | Benzophenones results in increased activity of ESR1 protein | increases activity | 12504345 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene affects the activity of ESR1 protein | affects activity | 20624995 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16972788 |
| D001564 | Benzo(a)pyrene | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with chrysene] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 11922773 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene promotes the reaction [ESR1 protein binds to CYP1A1 promoter] | affects binding|increases reaction | 16972788 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene promotes the reaction [ESR1 protein binds to TFF1 promoter] | affects binding|increases reaction | 16972788 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 12441364 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of ESR1 mRNA | increases expression | 11922773 |
| D001564 | Benzo(a)pyrene | fulvestrant inhibits the reaction [Benzo(a)pyrene promotes the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity|increases reaction | 12441364 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene affects the reaction [Ethinyl Estradiol results in decreased expression of ESR1 protein] | affects reaction|decreases expression | 17583486 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of ESR1 protein | decreases expression | 17583486 |
| D003374 | Coumarins | Coumarins analog results in decreased expression of ESR1 protein | decreases expression | 17275315 |
| C088015 | benzothiophene | benzothiophene analog binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15713417 |
| D001585 | Benzoyl Peroxide | Benzoyl Peroxide binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 15348454 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Butyrophenones results in increased degradation of ESR1 protein] | decreases reaction|increases degradation | 21041310 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Carbamazepine results in decreased expression of ESR1 mRNA] | decreases expression|decreases reaction | 16965676 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Carbamazepine results in decreased expression of ESR1 protein] | decreases expression|decreases reaction | 16965676 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Okadaic Acid results in increased degradation of ESR1 mRNA] | decreases reaction|increases degradation | 15965230 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Estradiol results in decreased expression of ESR1 protein] | decreases expression|decreases reaction | 16055746 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gonadotropin-Releasing Hormone results in decreased expression of ESR1 protein] | decreases expression|decreases reaction | 16055746 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [fulvestrant results in increased degradation of ESR1 protein] | decreases reaction|increases degradation | 20419096 |
| D001608 | Beryllium | Beryllium results in increased methylation of ESR1 gene | increases methylation | 11872642 |
| D019207 | beta Carotene | beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17051425 |
| D019207 | beta Carotene | beta Carotene inhibits the reaction [Genistein results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17051425 |
| D019207 | beta Carotene | beta Carotene inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 19340624 |
| C023888 | beta-hexachlorocyclohexane | beta-hexachlorocyclohexane results in decreased expression of ESR1 protein | decreases expression | 12948864 |
| C023888 | beta-hexachlorocyclohexane | beta-hexachlorocyclohexane results in increased activity of ESR1 protein | increases activity | 15064155 |
| C023888 | beta-hexachlorocyclohexane | beta-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| C023888 | beta-hexachlorocyclohexane | beta-hexachlorocyclohexane results in increased expression of ESR1 protein | increases expression | 15541753 |
| C095105 | bexarotene | bexarotene results in decreased expression of ESR1 mRNA | decreases expression | 17849452 |
| C004541 | biochanin A | biochanin A results in increased activity of ESR1 protein | increases activity | 18980245 |
| C004541 | biochanin A | biochanin A binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16076101 9751507 |
| C004541 | biochanin A | biochanin A binds to ESR1 protein | affects binding | 14579009 |
| C004541 | biochanin A | biochanin A inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D017438 | Bisphenol A-Glycidyl Methacrylate | [Bisphenol A-Glycidyl Methacrylate co-treated with 2,2-di(4-methacryloxyphenyl)propane co-treated with triethylene glycol dimethacrylate] results in increased activity of ESR1 protein | affects cotreatment|increases activity | 11145352 |
| D017438 | Bisphenol A-Glycidyl Methacrylate | Bisphenol A-Glycidyl Methacrylate results in increased activity of ESR1 protein | increases activity | 11145352 |
| C070515 | bisindolylmaleimide I | bisindolylmaleimide I results in increased expression of ESR1 protein | increases expression | 12927369 |
| C070515 | bisindolylmaleimide I | [Estradiol co-treated with bisindolylmaleimide I] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 12927369 |
| C006780 | bisphenol A | ESR1 protein inhibits the reaction [[bisphenol A co-treated with GH1 protein] results in increased activity of GHR1 protein] | affects cotreatment|decreases reaction|increases activity | 20467862 |
| C006780 | bisphenol A | ESR1 protein inhibits the reaction [[bisphenol A co-treated with GH1 protein] results in increased activity of GHR2 protein] | affects cotreatment|decreases reaction|increases activity | 20467862 |
| C006780 | bisphenol A | bisphenol A binds to ESR1 protein | affects binding | 11162928 |
| C006780 | bisphenol A | bisphenol A results in increased activity of ESR1 protein | increases activity | 18980245 |
| C006780 | bisphenol A | bisphenol A binds to ESR1 protein | affects binding | 11162928 |
| C006780 | bisphenol A | bisphenol A results in increased expression of ESR1 mRNA | increases expression | 16297413 |
| C006780 | bisphenol A | 4-hydroxytamoxifen inhibits the reaction [bisphenol A results in increased activity of ESR1 protein] | decreases reaction|increases activity | 14754635 |
| C006780 | bisphenol A | bisphenol A affects the activity of ESR1 protein | affects activity | 18635651 |
| C006780 | bisphenol A | [bisphenol A affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein] | affects activity|increases activity|increases reaction | 14975756 |
| C006780 | bisphenol A | bisphenol A affects the expression of ESR1 mRNA | affects expression | 20170705 |
| C006780 | bisphenol A | bisphenol A affects the localization of ESR1 protein | affects localization | 20678512 |
| C006780 | bisphenol A | bisphenol A analog binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 11335189 20427257 |
| C006780 | bisphenol A | bisphenol A binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 14709801 15110108 20304042 9751507 11258963 15026083 15952375 11530281 |
| C006780 | bisphenol A | bisphenol A binds to ESR1 protein | affects binding | 17400923 11162928 10964929 11518614 15521089 12753421 11693576 14579009 |
| C006780 | bisphenol A | [bisphenol A binds to ESR1 protein] which results in increased activity of ALPL protein | affects binding|increases activity | 12650720 |
| C006780 | bisphenol A | bisphenol A inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 11530281 |
| C006780 | bisphenol A | bisphenol A inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 11258963 9751507 14579009 10964929 |
| C006780 | bisphenol A | bisphenol A promotes the reaction [ESR1 protein binds to ESR1 protein] | affects binding|increases reaction | 15713566 |
| C006780 | bisphenol A | bisphenol A promotes the reaction [ESR1 protein binds to NCOA1 protein] | affects binding|increases reaction | 10964929 |
| C006780 | bisphenol A | bisphenol A promotes the reaction [ESR1 protein binds to NCOA2 protein] | affects binding|increases reaction | 10964929 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of ESR1 mRNA | decreases expression | 14709801 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of ESR1 protein | decreases expression | 14754635 14709801 12753421 |
| C006780 | bisphenol A | bisphenol A results in increased activity of and results in increased localization of ESR1 protein | increases activity|increases localization | 14754635 |
| C006780 | bisphenol A | bisphenol A results in increased activity of ESR1 protein | increases activity | 18028983 16029874 11145352 14975756 16328721 11485867 19161236 16756374 20868731 |
| C006780 | bisphenol A | bisphenol A results in increased activity of ESR1 protein mutant form | increases activity | 16328721 |
| C006780 | bisphenol A | [bisphenol A results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA | increases activity|increases expression | 14754635 |
| C006780 | bisphenol A | [bisphenol A results in increased activity of ESR1 protein] which results in increased expression of TFF1 mRNA | increases activity|increases expression | 14754635 |
| C006780 | bisphenol A | bisphenol A results in increased expression of ESR1 mRNA | increases expression | 12737316 |
| C006780 | bisphenol A | BRCA1 protein affects the reaction [bisphenol A results in increased activity of ESR1 protein] | affects reaction|increases activity | 20868731 |
| C006780 | bisphenol A | ESR1 protein affects the reaction [bisphenol A results in decreased expression of ATP2A3 mRNA] | affects reaction|decreases expression | 15223131 |
| C006780 | bisphenol A | ESR1 protein affects the reaction [bisphenol A results in decreased expression of CEACAM3 mRNA] | affects reaction|decreases expression | 15223131 |
| C006780 | bisphenol A | ESR1 protein affects the reaction [bisphenol A results in decreased expression of EIF5A mRNA] | affects reaction|decreases expression | 15223131 |
| C006780 | bisphenol A | ESR1 protein affects the reaction [bisphenol A results in decreased expression of ELAC2 mRNA] | affects reaction|decreases expression | 15223131 |
| C006780 | bisphenol A | ESR1 protein affects the reaction [bisphenol A results in decreased expression of ETFB mRNA] | affects reaction|decreases expression | 15223131 |
| C006780 | bisphenol A | ESR1 protein affects the reaction [bisphenol A results in decreased expression of PTPRO mRNA] | affects reaction|decreases expression | 15223131 |
| C006780 | bisphenol A | ESR1 protein affects the reaction [bisphenol A results in decreased expression of SEC16A mRNA] | affects reaction|decreases expression | 15223131 |
| C006780 | bisphenol A | ESR1 protein affects the reaction [bisphenol A results in increased expression of CCKBR mRNA] | affects reaction|increases expression | 15223131 |
| C006780 | bisphenol A | ESR1 protein affects the reaction [bisphenol A results in increased expression of HSPCB mRNA] | affects reaction|increases expression | 15223131 |
| C006780 | bisphenol A | ESR1 protein affects the reaction [bisphenol A results in increased expression of PIP5K1A mRNA] | affects reaction|increases expression | 15223131 |
| C006780 | bisphenol A | hydroxytamoxifen inhibits the reaction [bisphenol A results in increased activity of ESR1 protein] | decreases reaction|increases activity | 14709801 |
| C006780 | bisphenol A | NCOA2 protein promotes the reaction [bisphenol A results in increased activity of ESR1 protein] | increases activity|increases reaction | 16328721 |
| C006780 | bisphenol A | PD 98059 inhibits the reaction [[bisphenol A affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]] | affects activity|decreases reaction|increases activity|increases reaction | 14975756 |
| C006780 | bisphenol A | Tamoxifen inhibits the reaction [[bisphenol A affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]] | affects activity|decreases reaction|increases activity|increases reaction | 14975756 |
| C006780 | bisphenol A | Tamoxifen inhibits the reaction [bisphenol A results in increased activity of ESR1 protein] | decreases reaction|increases activity | 16328721 |
| C006780 | bisphenol A | Tamoxifen promotes the reaction [bisphenol A results in increased activity of ESR1 protein mutant form] | increases activity|increases reaction | 16328721 |
| C006780 | bisphenol A | bisphenol A results in increased expression of ESR1 mRNA | increases expression | 16759644 |
| C006780 | bisphenol A | bisphenol A binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 20209442 |
| C006780 | bisphenol A | bisphenol A binds to ESR1 protein | affects binding | 11162928 |
| C006780 | bisphenol A | [bisphenol A co-treated with fulvestrant] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 12927369 |
| C006780 | bisphenol A | bisphenol A promotes the reaction [ESR1 protein binds to HOXA10 promoter] | affects binding|increases reaction | 20181937 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of ESR1 protein | decreases expression | 12927369 |
| C006780 | bisphenol A | bisphenol A results in increased activity of ESR1 protein | increases activity | 18446233 |
| C006780 | bisphenol A | bisphenol A results in increased expression of ESR1 mRNA | increases expression | 12505546 |
| C006780 | bisphenol A | bisphenol A results in increased expression of ESR1 protein | increases expression | 17222491 15689538 12505546 |
| C006780 | bisphenol A | ESR1 protein affects the reaction [bisphenol A results in increased expression of INS2 protein] | affects reaction|increases expression | 18446233 |
| C006780 | bisphenol A | ESR1 protein promotes the reaction [bisphenol A results in increased phosphorylation of and results in increased activity of IGF1R protein] | increases activity|increases phosphorylation|increases reaction | 10965916 |
| C006780 | bisphenol A | fulvestrant promotes the reaction [bisphenol A results in decreased expression of ESR1 protein] | decreases expression|increases reaction | 12927369 |
| C006780 | bisphenol A | bisphenol A binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12206426 |
| C006780 | bisphenol A | bisphenol A binds to ESR1 protein | affects binding | 11162928 |
| C006780 | bisphenol A | bisphenol A results in increased expression of ESR1 mRNA | increases expression | 19009365 |
| C006780 | bisphenol A | bisphenol A binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15952375 |
| C006780 | bisphenol A | bisphenol A metabolite results in increased activity of ESR1 protein | increases activity | 17031755 |
| C006780 | bisphenol A | bisphenol A metabolite results in increased expression of ESR1 mRNA | increases expression | 15820104 |
| C006780 | bisphenol A | bisphenol A results in increased expression of ESR1 mRNA | increases expression | 15820104 17327697 |
| C006780 | bisphenol A | bisphenol A results in increased expression of ESR1 mRNA | increases expression | 20621667 |
| C006780 | bisphenol A | bisphenol A results in increased expression of ESR1 protein | increases expression | 14652134 |
| C006780 | bisphenol A | bisphenol A affects the expression of ESR1 mRNA | affects expression | 19696011 |
| C006780 | bisphenol A | bisphenol A affects the expression of ESR1 mRNA alternative form | affects expression | 17592034 |
| C006780 | bisphenol A | bisphenol A binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 15348454 |
| C006780 | bisphenol A | bisphenol A binds to ESR1 protein | affects binding | 11086226 15204698 |
| C006780 | bisphenol A | bisphenol A inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 10580743 15204698 |
| C006780 | bisphenol A | bisphenol A inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ESR1 protein] | affects cotreatment|decreases reaction|increases expression | 18653720 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of ESR1 mRNA | decreases expression | 19577632 20144698 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of ESR1 protein | decreases expression | 17592034 |
| C006780 | bisphenol A | bisphenol A results in increased activity of ESR1 protein | increases activity | 11750080 12504345 17174995 18028983 |
| C006780 | bisphenol A | bisphenol A results in increased expression of ESR1 mRNA | increases expression | 12062901 15947454 17589598 18569609 |
| C006780 | bisphenol A | bisphenol A results in increased expression of ESR1 protein | increases expression | 17157476 |
| C006780 | bisphenol A | bisphenol A promotes the reaction [ESR1 protein binds to ESR1 protein] | affects binding|increases reaction | 15891078 |
| C006780 | bisphenol A | bisphenol A binds to ESR1 protein | affects binding | 19303142 |
| C006780 | bisphenol A | bisphenol A results in increased expression of ESR1 mRNA | increases expression | 17258427 |
| C006780 | bisphenol A | bisphenol A results in increased expression of ESR1 mRNA | increases expression | 16198636 |
| C006780 | bisphenol A | bisphenol A results in increased activity of ESR1 protein | increases activity | 11403899 |
| C492482 | bisphenol B | bisphenol B results in increased activity of ESR1 protein | increases activity | 12504345 11750080 |
| C001371 | boldenone undecylenate | [boldenone undecylenate co-treated with estradiol 3-benzoate] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 16023321 |
| C037311 | bromoethane | bromoethane results in increased expression of ESR1 mRNA | increases expression | 15922381 |
| C037311 | bromoethane | bromoethane results in increased expression of ESR1 protein | increases expression | 15922381 |
| C037311 | bromoethane | bromoethane results in increased expression of ESR1 mRNA | increases expression | 15922381 |
| C037311 | bromoethane | bromoethane results in increased expression of ESR1 protein | increases expression | 15922381 |
| C100092 | bromophos | bromophos results in increased activity of ESR1 protein | increases activity | 15064155 |
| D002083 | Butylated Hydroxyanisole | Butylated Hydroxyanisole binds to ESR1 protein | affects binding | 12822488 14579009 |
| D002083 | Butylated Hydroxyanisole | Butylated Hydroxyanisole inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 12822488 |
| D002083 | Butylated Hydroxyanisole | Butylated Hydroxyanisole results in decreased expression of ESR1 mRNA | decreases expression | 12822488 |
| D002083 | Butylated Hydroxyanisole | Butylated Hydroxyanisole results in increased activity of ESR1 protein | increases activity | 16756374 |
| C027561 | butylbenzyl phthalate | butylbenzyl phthalate binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15840436 |
| C027561 | butylbenzyl phthalate | butylbenzyl phthalate results in decreased methylation of ESR1 promoter | decreases methylation | 16326419 |
| C027561 | butylbenzyl phthalate | Tamoxifen inhibits the reaction [butylbenzyl phthalate binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 15840436 |
| C027561 | butylbenzyl phthalate | butylbenzyl phthalate metabolite binds to ESR1 protein | affects binding | 11162928 |
| C027561 | butylbenzyl phthalate | butylbenzyl phthalate results in increased activity of ESR1 protein | increases activity | 11403899 |
| C038091 | butylparaben | butylparaben binds to ESR1 protein | affects binding | 15204698 |
| C038091 | butylparaben | butylparaben inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 15204698 |
| C006862 | butylphen | butylphen results in increased activity of ESR1 protein | increases activity | 18028983 |
| C006862 | butylphen | butylphen results in increased activity of ESR1 protein | increases activity | 18028983 |
| D002087 | Butyrates | [estradiol dipropionate co-treated with Butyrates] results in decreased expression of ESR1 protein | affects cotreatment|decreases expression | 15930180 |
| D002090 | Butyrophenones | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Butyrophenones results in increased degradation of ESR1 protein] | decreases reaction|increases degradation | 21041310 |
| D002090 | Butyrophenones | Butyrophenones inhibits the reaction [[Estradiol results in increased activity of ESR1 protein] which results in increased expression of CCND1 mRNA] | decreases reaction|increases activity|increases expression | 21041310 |
| D002090 | Butyrophenones | Butyrophenones inhibits the reaction [[Estradiol results in increased activity of ESR1 protein] which results in increased expression of SERPINB9 mRNA] | decreases reaction|increases activity|increases expression | 21041310 |
| D002090 | Butyrophenones | Butyrophenones results in decreased expression of ESR1 mRNA | decreases expression | 21041310 |
| D002090 | Butyrophenones | Butyrophenones results in increased degradation of ESR1 protein | increases degradation | 21041310 |
| C402943 | bu-zhong-yi-qi-tang | bu-zhong-yi-qi-tang inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 17089059 |
| D002104 | Cadmium | Cadmium results in decreased expression of ESR1 protein | decreases expression | 17125913 |
| D002104 | Cadmium | Cadmium results in increased activity of ESR1 protein | increases activity | 16635015 |
| D002104 | Cadmium | Cadmium results in increased activity of ESR1 protein mutant form | increases activity | 16635015 |
| D002104 | Cadmium | Melatonin inhibits the reaction [Cadmium results in increased activity of ESR1 protein] | decreases reaction|increases activity | 16635015 |
| D019256 | Cadmium Chloride | Cadmium Chloride results in decreased expression of ESR1 protein | decreases expression | 17125913 |
| D002215 | Captan | Captan binds to ESR1 protein | affects binding | 15253041 |
| D002220 | Carbamazepine | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Carbamazepine results in decreased expression of ESR1 mRNA] | decreases expression|decreases reaction | 16965676 |
| D002220 | Carbamazepine | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Carbamazepine results in decreased expression of ESR1 protein] | decreases expression|decreases reaction | 16965676 |
| D002220 | Carbamazepine | Carbamazepine results in decreased expression of ESR1 mRNA | decreases expression | 16965676 |
| D002220 | Carbamazepine | Carbamazepine results in decreased expression of ESR1 protein | decreases expression | 16965676 |
| D002220 | Carbamazepine | Carbamazepine results in increased expression of ESR1 mRNA | increases expression | 19490052 |
| D012721 | Carbaryl | Carbaryl binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 16626760 |
| D012721 | Carbaryl | Carbaryl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 9126867 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride results in decreased expression of ESR1 mRNA | decreases expression | 17484886 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride results in increased expression of ESR1 mRNA | increases expression | 14716833 |
| C103436 | CB 1093 | CB 1093 results in increased expression of ESR1 protein | increases expression | 17029789 |
| C450419 | CHF 4056 | CHF 4056 binds to ESR1 protein | affects binding | 11861784 |
| D002706 | Chlordan | [Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D002706 | Chlordan | [Toxaphene co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D002706 | Chlordan | Chlordan results in increased activity of ESR1 protein | increases activity | 15064155 |
| D002706 | Chlordan | Chlordan results in increased activity of ESR1 protein mutant form | increases activity | 17141713 |
| D002706 | Chlordan | [Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D002706 | Chlordan | [Toxaphene co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D002706 | Chlordan | [Toxaphene co-treated with Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D007631 | Chlordecone | Chlordecone inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D007631 | Chlordecone | Chlordecone binds to ESR1 protein | affects binding | 11162928 |
| D007631 | Chlordecone | Chlordecone binds to ESR1 protein | affects binding | 11162928 |
| D007631 | Chlordecone | Chlordecone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16626760 10774817 15026083 |
| D007631 | Chlordecone | Chlordecone binds to ESR1 protein | affects binding | 15253041 9751507 14579009 11162928 |
| D007631 | Chlordecone | Chlordecone inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 15253041 9751507 |
| D007631 | Chlordecone | Chlordecone results in increased activity of ESR1 protein mutant form | increases activity | 17141713 |
| D007631 | Chlordecone | Chlordecone inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| D007631 | Chlordecone | Chlordecone binds to ESR1 protein | affects binding | 11162928 |
| D007631 | Chlordecone | 4-hydroxytamoxifen inhibits the reaction [Chlordecone results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 8800639 |
| D007631 | Chlordecone | Chlordecone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9460653 |
| D007631 | Chlordecone | Chlordecone binds to ESR1 protein | affects binding | 11162928 |
| D007631 | Chlordecone | Chlordecone results in increased expression of ESR1 mRNA | increases expression | 8800639 |
| D007631 | Chlordecone | ICI 164384 inhibits the reaction [Chlordecone results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 8800639 |
| C023386 | chlorinated dibenzofurans | [Polychlorinated Biphenyls co-treated with chlorinated dibenzofurans co-treated with polychlorodibenzo-4-dioxin analog] results in decreased expression of ESR1 mRNA | affects cotreatment|decreases expression | 12883090 |
| C023386 | chlorinated dibenzofurans | [Polychlorinated Biphenyls co-treated with polychlorodibenzo-4-dioxin co-treated with chlorinated dibenzofurans] results in decreased expression of ESR1 mRNA | affects cotreatment|decreases expression | 15858227 |
| C004659 | chlorobenzilate | chlorobenzilate results in increased activity of ESR1 protein | increases activity | 15064155 |
| C004663 | chloropropylate | chloropropylate results in increased activity of ESR1 protein | increases activity | 15064155 |
| D004390 | Chlorpyrifos | Chlorpyrifos results in increased activity of ESR1 protein | increases activity | 15064155 |
| D002839 | Chromans | Chromans analog results in decreased activity of ESR1 protein | decreases activity | 15737489 |
| C031180 | chrysene | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with chrysene] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 11922773 |
| C031180 | chrysene | chrysene results in increased expression of ESR1 mRNA | increases expression | 11922773 |
| C043561 | chrysin | chrysin binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16972788 9751507 |
| C043561 | chrysin | chrysin promotes the reaction [ESR1 protein binds to CYP1A1 promoter] | affects binding|increases reaction | 16972788 |
| C043561 | chrysin | chrysin promotes the reaction [ESR1 protein binds to TFF1 promoter] | affects binding|increases reaction | 16972788 |
| D002996 | Clomiphene | Clomiphene binds to ESR1 protein | affects binding | 15521089 |
| D002996 | Clomiphene | Clomiphene binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 18348622 |
| D003375 | Coumestrol | Coumestrol binds to ESR1 protein | affects binding | 11162928 |
| D003375 | Coumestrol | Coumestrol binds to ESR1 protein | affects binding | 11162928 |
| D003375 | Coumestrol | CCND1 protein promotes the reaction [Coumestrol results in increased activity of ESR1 protein] | increases activity|increases reaction | 16328721 |
| D003375 | Coumestrol | Coumestrol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15876408 9751507 10397250 |
| D003375 | Coumestrol | Coumestrol binds to ESR1 protein | affects binding | 16566672 11162928 11518614 |
| D003375 | Coumestrol | [Coumestrol binds to ESR1 protein] which results in increased activity of ALPL protein | affects binding|increases activity | 12650720 |
| D003375 | Coumestrol | Coumestrol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 16566672 |
| D003375 | Coumestrol | Coumestrol promotes the reaction [NCOA2 protein binds to ESR1 protein] | affects binding|increases reaction | 15084758 |
| D003375 | Coumestrol | Coumestrol results in decreased expression of ESR1 protein | decreases expression | 11867264 |
| D003375 | Coumestrol | Coumestrol results in increased activity of ESR1 protein | increases activity | 16118406 16328721 |
| D003375 | Coumestrol | ESR1 protein affects the susceptibility to Coumestrol | affects response to substance | 17275032 |
| D003375 | Coumestrol | fulvestrant inhibits the reaction [[Coumestrol binds to ESR1 protein] which results in increased activity of ALPL protein] | affects binding|decreases reaction|increases activity | 12650720 |
| D003375 | Coumestrol | Tamoxifen inhibits the reaction [Coumestrol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 16328721 |
| D003375 | Coumestrol | Tamoxifen promotes the reaction [Coumestrol results in increased activity of ESR1 protein mutant form] | increases activity|increases reaction | 16328721 |
| D003375 | Coumestrol | Coumestrol binds to ESR1 protein | affects binding | 11162928 |
| D003375 | Coumestrol | Coumestrol binds to ESR1 protein | affects binding | 11162928 |
| D003375 | Coumestrol | Coumestrol results in increased activity of ESR1 protein | increases activity | 17174995 |
| D003474 | Curcumin | Curcumin inhibits the reaction [Estradiol results in increased degradation of ESR1 protein] | decreases reaction|increases degradation | 15899841 |
| D003474 | Curcumin | Curcumin inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein] | decreases reaction|increases phosphorylation | 15899841 |
| D003474 | Curcumin | Curcumin inhibits the reaction [fulvestrant results in increased degradation of ESR1 protein] | decreases reaction|increases degradation | 15899841 |
| D003474 | Curcumin | Curcumin results in decreased expression of ESR1 protein | decreases expression | 18347134 |
| D003474 | Curcumin | Curcumin results in decreased expression of ESR1 | decreases expression | 18462866 |
| C007168 | cyanazine | cyanazine inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| C007168 | cyanazine | cyanazine binds to ESR1 protein | affects binding | 8858116 |
| C007168 | cyanazine | cyanazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 8858116 |
| C002488 | cyanophenphos | cyanophenphos results in increased activity of ESR1 protein | increases activity | 15064155 |
| D003520 | Cyclophosphamide | [Doxorubicin co-treated with Cyclophosphamide] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 16322899 |
| C052570 | cyfluthrin | cyfluthrin results in increased activity of ESR1 protein | increases activity | 15064155 |
| C037304 | cyhalothrin | cyhalothrin results in decreased expression of ESR1 mRNA | decreases expression | 18419197 |
| C037304 | cyhalothrin | cyhalothrin results in decreased expression of ESR1 protein | decreases expression | 18419197 |
| C017160 | cypermethrin | cypermethrin metabolite binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16395479 |
| C017160 | cypermethrin | cypermethrin results in increased activity of ESR1 protein | increases activity | 15064155 |
| C017160 | cypermethrin | cypermethrin binds to ESR1 protein | affects binding | 12396874 |
| C004742 | daidzein | daidzein binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9751507 16076101 15876408 |
| C004742 | daidzein | daidzein binds to ESR1 protein | affects binding | 14579009 16773531 16506809 |
| C004742 | daidzein | [daidzein binds to ESR1 protein] which results in increased activity of ALPL protein | affects binding|increases activity | 12650720 |
| C004742 | daidzein | [daidzein co-treated with ESR1 protein] results in decreased expression of EGFR mRNA | affects cotreatment|decreases expression | 19347870 |
| C004742 | daidzein | [daidzein co-treated with ESR1 protein] results in decreased expression of EGFR protein | affects cotreatment|decreases expression | 19347870 |
| C004742 | daidzein | [daidzein co-treated with ESR1 protein] results in increased expression of BGLAP mRNA | affects cotreatment|increases expression | 19347870 |
| C004742 | daidzein | [daidzein co-treated with ESR1 protein] results in increased expression of BSP mRNA | affects cotreatment|increases expression | 19347870 |
| C004742 | daidzein | daidzein inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| C004742 | daidzein | daidzein metabolite binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15084758 |
| C004742 | daidzein | daidzein metabolite promotes the reaction [NCOA2 protein binds to ESR1 protein] | affects binding|increases reaction | 15084758 |
| C004742 | daidzein | daidzein promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 16118406 |
| C004742 | daidzein | daidzein results in decreased expression of ESR1 mRNA | decreases expression | 16033089 |
| C004742 | daidzein | daidzein results in decreased expression of ESR1 protein | decreases expression | 16033089 |
| C004742 | daidzein | daidzein results in increased activity of ESR1 protein | increases activity | 16118406 19161236 |
| C004742 | daidzein | Estradiol affects the reaction [daidzein metabolite affects the activity of ESR1 protein] | affects activity|affects reaction | 16965913 |
| C004742 | daidzein | fulvestrant inhibits the reaction [[daidzein binds to ESR1 protein] which results in increased activity of ALPL protein] | affects binding|decreases reaction|increases activity | 12650720 |
| C004742 | daidzein | daidzein results in increased activity of ESR1 protein | increases activity | 19495926 |
| C004742 | daidzein | daidzein results in increased activity of ESR1 protein | increases activity | 11403899 |
| D008939 | Mitotane | Mitotane inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D008939 | Mitotane | Mitotane binds to ESR1 protein | affects binding | 14579009 |
| D008939 | Mitotane | Mitotane inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 8930550 14579009 |
| D008939 | Mitotane | Mitotane binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12206426 |
| D008939 | Mitotane | Mitotane inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 10580743 |
| C021112 | DDOH | DDOH inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D003634 | DDT | DDT inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D003634 | DDT | DDT binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12676605 15026083 16626760 |
| D003634 | DDT | DDT binds to ESR1 protein | affects binding | 12676605 |
| D003634 | DDT | DDT results in increased activity of ESR1 protein | increases activity | 15064155 11485867 |
| D003634 | DDT | [Lindane co-treated with DDT] results in increased expression of ESR1 | affects cotreatment|increases expression | 16329587 |
| D003634 | DDT | DDT results in increased expression of ESR1 protein | increases expression | 15541753 |
| D003634 | DDT | DDT binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12206426 |
| D003634 | DDT | DDT binds to ESR1 protein | affects binding | 11162928 |
| C017180 | decamethrin | decamethrin binds to ESR1 protein | affects binding | 12396874 |
| C014347 | decitabine | [decitabine co-treated with TFAP2C protein] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 19458056 |
| C014347 | decitabine | [decitabine co-treated with trichostatin A] affects the expression of ESR1 mRNA | affects cotreatment|affects expression | 18264725 |
| C014347 | decitabine | [decitabine co-treated with trichostatin A] promotes the reaction [TFAP2C protein binds to ESR1 promoter] | affects binding|affects cotreatment|increases reaction | 19458056 |
| C014347 | decitabine | [decitabine co-treated with trichostatin A] promotes the reaction [TFAP2C protein results in increased expression of ESR1 mRNA] | affects cotreatment|increases expression|increases reaction | 19458056 |
| C014347 | decitabine | [decitabine co-treated with trichostatin A] results in decreased expression of ESR1 mRNA | affects cotreatment|decreases expression | 17891453 |
| C014347 | decitabine | [decitabine co-treated with trichostatin A] results in decreased expression of ESR1 protein | affects cotreatment|decreases expression | 17891453 |
| C014347 | decitabine | [decitabine co-treated with trichostatin A] results in decreased stability of ESR1 mRNA | affects cotreatment|decreases stability | 17891453 |
| C014347 | decitabine | [decitabine co-treated with trichostatin A] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 19458056 17533736 |
| C014347 | decitabine | decitabine promotes the reaction [trichostatin A results in increased expression of ESR1 mRNA] | increases expression|increases reaction | 18092350 |
| C014347 | decitabine | decitabine results in decreased expression of ESR1 mRNA | decreases expression | 17891453 |
| C014347 | decitabine | decitabine results in decreased expression of ESR1 protein | decreases expression | 17891453 |
| C014347 | decitabine | decitabine results in decreased stability of ESR1 mRNA | decreases stability | 17891453 |
| C014347 | decitabine | decitabine results in increased expression of ESR1 mRNA | increases expression | 18701604 19458056 |
| C014347 | decitabine | TFAP2C protein promotes the reaction [[decitabine co-treated with trichostatin A] results in increased expression of ESR1 mRNA] | affects cotreatment|increases expression|increases reaction | 19458056 |
| D003687 | Dehydroepiandrosterone | Dehydroepiandrosterone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15994348 |
| D003687 | Dehydroepiandrosterone | Dehydroepiandrosterone binds to ESR1 protein | affects binding | 11162928 |
| D003687 | Dehydroepiandrosterone | Dehydroepiandrosterone results in increased expression of ESR1 mRNA | increases expression | 17823450 18709148 |
| C086916 | delta-hexachlorocyclohexane | delta-hexachlorocyclohexane results in increased activity of ESR1 protein | increases activity | 15064155 |
| C406602 | deoxymiroestrol | deoxymiroestrol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15876408 |
| D017135 | Desogestrel | Desogestrel results in increased activity of ESR1 protein | increases activity | 10836199 |
| D003907 | Dexamethasone | Dexamethasone results in decreased expression of ESR1 mRNA | decreases expression | 19022236 16691199 |
| C061481 | dibenzoylmethane | dibenzoylmethane inhibits the reaction [ESR1 protein binds to BCL2 enhancer] | affects binding|decreases reaction | 16051634 |
| C061481 | dibenzoylmethane | dibenzoylmethane inhibits the reaction [ESR1 protein binds to MYC enhancer] | affects binding|decreases reaction | 16051634 |
| C061481 | dibenzoylmethane | dibenzoylmethane inhibits the reaction [ESR1 protein binds to TERT enhancer] | affects binding|decreases reaction | 16051634 |
| C088674 | dibromoacetic acid | dibromoacetic acid inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 10580743 |
| D003993 | Dibutyl Phthalate | Dibutyl Phthalate results in increased activity of ESR1 protein | increases activity | 18980245 |
| D003993 | Dibutyl Phthalate | Dibutyl Phthalate analog binds to ESR1 protein | affects binding | 15464722 |
| D003993 | Dibutyl Phthalate | Dibutyl Phthalate binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15840436 |
| D003993 | Dibutyl Phthalate | Dibutyl Phthalate results in decreased methylation of ESR1 promoter | decreases methylation | 16326419 |
| D003993 | Dibutyl Phthalate | Tamoxifen inhibits the reaction [Dibutyl Phthalate binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 15840436 |
| C011445 | dichlofenthion | dichlofenthion results in increased activity of ESR1 protein | increases activity | 15064155 |
| C012891 | dichlorfop-methyl | dichlorfop-methyl binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9460653 |
| D003632 | Dichlorodiphenyldichloroethane | Dichlorodiphenyldichloroethane analog results in increased activity of ESR1 protein | increases activity | 15064155 |
| D003632 | Dichlorodiphenyldichloroethane | Dichlorodiphenyldichloroethane binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12206426 |
| D003633 | Dichlorodiphenyl Dichloroethylene | Dichlorodiphenyl Dichloroethylene inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D003633 | Dichlorodiphenyl Dichloroethylene | [o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9118873 |
| D003633 | Dichlorodiphenyl Dichloroethylene | Dichlorodiphenyl Dichloroethylene analog results in increased activity of ESR1 protein | increases activity | 15064155 |
| D003633 | Dichlorodiphenyl Dichloroethylene | Dichlorodiphenyl Dichloroethylene binds to ESR1 protein | affects binding | 14579009 |
| D003633 | Dichlorodiphenyl Dichloroethylene | Dichlorodiphenyl Dichloroethylene inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D003633 | Dichlorodiphenyl Dichloroethylene | Dichlorodiphenyl Dichloroethylene metabolite binds to ESR1 protein | affects binding | 10492897 |
| D003633 | Dichlorodiphenyl Dichloroethylene | Dichlorodiphenyl Dichloroethylene affects the expression of ESR1 mRNA | affects expression | 16707152 16765462 |
| D003633 | Dichlorodiphenyl Dichloroethylene | Dichlorodiphenyl Dichloroethylene binds to ESR1 protein | affects binding | 11162928 |
| D003633 | Dichlorodiphenyl Dichloroethylene | Dichlorodiphenyl Dichloroethylene results in increased activity of ESR1 protein | increases activity | 17174995 |
| D004010 | Dicofol | Dicofol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D004010 | Dicofol | [o,p'-DDT co-treated with Dicofol] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9118873 |
| D004010 | Dicofol | Dicofol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 10789375 16337670 |
| D004010 | Dicofol | Dicofol binds to ESR1 protein | affects binding | 15253041 |
| D004010 | Dicofol | Dicofol results in increased activity of ESR1 protein | increases activity | 15064155 |
| C036042 | dicyclohexyl phthalate | dicyclohexyl phthalate binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15840436 |
| C036042 | dicyclohexyl phthalate | Tamoxifen inhibits the reaction [dicyclohexyl phthalate binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 15840436 |
| D004026 | Dieldrin | [Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D004026 | Dieldrin | [Toxaphene co-treated with Dieldrin] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D004026 | Dieldrin | Dieldrin binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 10774817 16626760 |
| D004026 | Dieldrin | Dieldrin binds to ESR1 protein | affects binding | 14579009 |
| D004026 | Dieldrin | [Dieldrin co-treated with alachlor] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D004026 | Dieldrin | [Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D004026 | Dieldrin | Dieldrin inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004026 | Dieldrin | Dieldrin inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA] | decreases expression|decreases reaction | 15261991 |
| D004026 | Dieldrin | Dieldrin results in increased activity of ESR1 protein | increases activity | 15064155 |
| D004026 | Dieldrin | Dieldrin results in increased expression of ESR1 mRNA | increases expression | 11922773 |
| D004026 | Dieldrin | [o,p'-DDT co-treated with Methoxychlor co-treated with Dieldrin] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 11922773 |
| D004026 | Dieldrin | [Toxaphene co-treated with Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D004026 | Dieldrin | Dieldrin affects the expression of ESR1 mRNA | affects expression | 16707152 |
| D004026 | Dieldrin | Dieldrin binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9460653 |
| D004026 | Dieldrin | Dieldrin results in increased activity of ESR1 protein | increases activity | 17174995 |
| D004028 | Dienestrol | Dienestrol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15026083 |
| D004051 | Diethylhexyl Phthalate | Diethylhexyl Phthalate binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15840436 |
| D004051 | Diethylhexyl Phthalate | Diethylhexyl Phthalate results in increased activity of ESR1 protein | increases activity | 16756374 |
| D004051 | Diethylhexyl Phthalate | Tamoxifen inhibits the reaction [Diethylhexyl Phthalate binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 15840436 |
| C007379 | diethyl phthalate | diethyl phthalate analog binds to ESR1 protein | affects binding | 15464722 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol binds to ESR1 protein | affects binding | 11162928 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in increased activity of ESR1 protein | increases activity | 18980245 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol binds to ESR1 protein | affects binding | 11162928 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12579585 15120416 10397250 18028983 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol binds to ESR1 protein | affects binding | 9751507 15253041 11162928 11518614 17287592 17400923 15521089 10964929 |
| D004054 | Diethylstilbestrol | [Diethylstilbestrol binds to ESR1 protein] which binds to NCOA2 protein | affects binding | 15123288 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9751507 10964929 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol promotes the reaction [ESR1 protein binds to HOXA10 promoter] | affects binding|increases reaction | 15236964 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol promotes the reaction [ESR1 protein binds to NCOA1 protein] | affects binding|increases reaction | 10964929 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol promotes the reaction [ESR1 protein binds to NCOA2 protein] | affects binding|increases reaction | 10964929 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol promotes the reaction [NCOA2 protein binds to ESR1 protein] | affects binding|increases reaction | 15084758 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in increased activity of ESR1 protein | increases activity | 11331656 9846162 17141713 19161236 |
| D004054 | Diethylstilbestrol | fulvestrant inhibits the reaction [Diethylstilbestrol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 18028983 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol affects the activity of ESR1 protein | affects activity | 15451043 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol binds to ESR1 protein | affects binding | 15001543 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol affects the activity of ESR1 protein | affects activity | 16468032 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15465114 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol binds to ESR1 protein | affects binding | 11162928 |
| D004054 | Diethylstilbestrol | [Diethylstilbestrol co-treated with sodium arsenite] results in increased expression of ESR1 protein | affects cotreatment|increases expression | 16452187 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in decreased expression of ESR1 mRNA | decreases expression | 17213693 14871586 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in decreased expression of ESR1 protein | decreases expression | 15082075 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in increased expression of ESR1 mRNA | increases expression | 15070830 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in increased expression of ESR1 protein | increases expression | 15082075 |
| D004054 | Diethylstilbestrol | ESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of AR protein] | affects reaction|decreases expression | 15458790 |
| D004054 | Diethylstilbestrol | ESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of HOXA10 mRNA] | affects reaction|decreases expression | 15458790 |
| D004054 | Diethylstilbestrol | ESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of HOXA11 mRNA] | affects reaction|decreases expression | 15458790 |
| D004054 | Diethylstilbestrol | ESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of WNT7A mRNA] | affects reaction|decreases expression | 15458790 |
| D004054 | Diethylstilbestrol | ESR1 protein affects the susceptibility to Diethylstilbestrol | affects response to substance | 15458790 |
| D004054 | Diethylstilbestrol | ESR1 protein promotes the reaction [Diethylstilbestrol results in increased phosphorylation of and results in increased activity of IGF1R protein] | increases activity|increases phosphorylation|increases reaction | 10965916 |
| D004054 | Diethylstilbestrol | [sodium arsenite co-treated with Diethylstilbestrol] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 19665456 |
| D004054 | Diethylstilbestrol | [sodium arsenite co-treated with Diethylstilbestrol] results in increased expression of ESR1 protein | affects cotreatment|increases expression | 16712894 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol binds to ESR1 protein | affects binding | 11944962 11162928 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in increased activity of ESR1 protein | increases activity | 11331656 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in increased expression of ESR1 mRNA | increases expression | 17823450 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in increased expression of ESR1 protein | increases expression | 14652134 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol affects the activity of ESR1 protein | affects activity | 15746884 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol affects the expression of ESR1 mRNA | affects expression | 19696011 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol affects the expression of ESR1 mRNA alternative form | affects expression | 17592034 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol affects the expression of ESR1 protein | affects expression | 17592034 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol binds to ESR1 protein | affects binding | 15204698 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 15204698 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ESR1 protein] | affects cotreatment|decreases reaction|increases expression | 18653720 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in increased activity of ESR1 protein | increases activity | 17174995 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in increased expression of ESR1 protein | increases expression | 14749301 11748029 15855622 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol binds to ESR1 protein | affects binding | 11944962 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol binds to ESR1 protein | affects binding | 19303142 |
| C089799 | diheptyl phthalate | diheptyl phthalate analog binds to ESR1 protein | affects binding | 15464722 |
| D002117 | Calcitriol | Calcitriol results in increased expression of ESR1 mRNA | increases expression | 16002434 |
| C025605 | diisobutyl phthalate | diisobutyl phthalate binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15840436 |
| C025605 | diisobutyl phthalate | Tamoxifen inhibits the reaction [diisobutyl phthalate binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 15840436 |
| C015835 | dimethyl-4-toluidine | dimethyl-4-toluidine binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 15348454 |
| D015127 | 9,10-Dimethyl-1,2-benzanthracene | 9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ESR1 protein | decreases expression | 16891317 |
| D015127 | 9,10-Dimethyl-1,2-benzanthracene | [Estradiol co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of ESR1 protein | affects cotreatment|decreases expression | 16891317 |
| D015127 | 9,10-Dimethyl-1,2-benzanthracene | [Methylnitrosourea co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of ESR1 protein | affects cotreatment|decreases expression | 16891317 |
| D004121 | Dimethyl Sulfoxide | Dimethyl Sulfoxide promotes the reaction [ESR1 protein binds to CAD promoter] | affects binding|increases reaction | 16675542 |
| C027387 | di-n-hexyl phthalate | di-n-hexyl phthalate analog binds to ESR1 protein | affects binding | 15464722 |
| C027387 | di-n-hexyl phthalate | di-n-hexyl phthalate binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15840436 |
| C027387 | di-n-hexyl phthalate | Tamoxifen inhibits the reaction [di-n-hexyl phthalate binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 15840436 |
| C010715 | di-n-octyl phthalate | di-n-octyl phthalate analog binds to ESR1 protein | affects binding | 15464722 |
| C034171 | di-n-pentyl phthalate | di-n-pentyl phthalate analog binds to ESR1 protein | affects binding | 15464722 |
| C034171 | di-n-pentyl phthalate | di-n-pentyl phthalate binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15840436 |
| C034171 | di-n-pentyl phthalate | Tamoxifen inhibits the reaction [di-n-pentyl phthalate binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 15840436 |
| C106479 | di-n-propylphthalate | di-n-propylphthalate analog binds to ESR1 protein | affects binding | 15464722 |
| D004147 | Dioxins | Dioxins binds to ESR1 protein | affects binding | 10492897 |
| C004839 | dioxybenzone | dioxybenzone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16079615 |
| C109695 | dong quai | dong quai binds to ESR1 protein | affects binding | 11368622 |
| C109695 | dong quai | dong quai inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 11368622 |
| D004317 | Doxorubicin | [Doxorubicin co-treated with Cyclophosphamide] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 16322899 |
| D004317 | Doxorubicin | Doxorubicin promotes the reaction [CARM1 protein binds to ESR1 promoter] | affects binding|increases reaction | 19351845 |
| D004317 | Doxorubicin | Doxorubicin promotes the reaction [CREBBP protein binds to ESR1 promoter] | affects binding|increases reaction | 19351845 |
| D004317 | Doxorubicin | Doxorubicin promotes the reaction [JUN protein binds to ESR1 promoter] | affects binding|increases reaction | 19351845 |
| D004317 | Doxorubicin | Doxorubicin promotes the reaction [SP1 protein binds to ESR1 promoter] | affects binding|increases reaction | 19351845 |
| D004317 | Doxorubicin | Doxorubicin promotes the reaction [TP53 protein binds to ESR1 promoter] | affects binding|increases reaction | 19351845 |
| D004317 | Doxorubicin | Doxorubicin results in increased expression of ESR1 mRNA | increases expression | 19351845 |
| D004317 | Doxorubicin | Doxorubicin results in increased expression of ESR1 protein | increases expression | 19351845 |
| D004317 | Doxorubicin | TP53 protein affects the reaction [Doxorubicin results in increased expression of ESR1 mRNA] | affects reaction|increases expression | 19351845 |
| D004317 | Doxorubicin | TP53 protein affects the reaction [Doxorubicin results in increased expression of ESR1 protein] | affects reaction|increases expression | 19351845 |
| D004365 | Drugs, Chinese Herbal | Drugs, Chinese Herbal binds to ESR1 protein | affects binding | 17095596 |
| C506907 | EHT 1864 | EHT 1864 results in decreased activity of ESR1 protein | decreases activity | 21118977 |
| C506907 | EHT 1864 | EHT 1864 results in decreased expression of ESR1 mRNA | decreases expression | 21118977 |
| C506907 | EHT 1864 | EHT 1864 results in decreased expression of ESR1 protein | decreases expression | 21118977 |
| D004642 | Emodin | Emodin results in increased activity of ESR1 protein | increases activity | 19161236 |
| D004726 | Endosulfan | Endosulfan inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D004726 | Endosulfan | Endosulfan results in increased activity of ESR1 protein | increases activity | 18980245 |
| D004726 | Endosulfan | Endosulfan results in increased expression of ESR1 mRNA | increases expression | 12735107 |
| D004726 | Endosulfan | [Endosulfan affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein] | affects activity|increases activity|increases reaction | 14975756 |
| D004726 | Endosulfan | Endosulfan binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 10397250 10774817 16626760 |
| D004726 | Endosulfan | Endosulfan binds to ESR1 protein | affects binding | 14579009 |
| D004726 | Endosulfan | Endosulfan inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004726 | Endosulfan | Endosulfan results in decreased expression of ESR1 mRNA | decreases expression | 15261991 |
| D004726 | Endosulfan | Endosulfan results in increased activity of ESR1 protein | increases activity | 15064155 |
| D004726 | Endosulfan | PD 98059 inhibits the reaction [[Endosulfan affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]] | affects activity|decreases reaction|increases activity|increases reaction | 14975756 |
| D004726 | Endosulfan | Tamoxifen inhibits the reaction [[Endosulfan affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]] | affects activity|decreases reaction|increases activity|increases reaction | 14975756 |
| D004726 | Endosulfan | Endosulfan binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9460653 |
| D004726 | Endosulfan | Endosulfan binds to ESR1 protein | affects binding | 11162928 |
| D004726 | Endosulfan | Endosulfan results in decreased expression of ESR1 mRNA | decreases expression | 18790044 |
| D004726 | Endosulfan | Endosulfan results in decreased expression of ESR1 protein | decreases expression | 18790044 |
| D004726 | Endosulfan | Endosulfan results in increased activity of ESR1 protein | increases activity | 17174995 |
| D004732 | Endrin | Endrin binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16626760 |
| D004732 | Endrin | Endrin results in increased activity of ESR1 protein | increases activity | 15064155 |
| D004857 | Equilin | Equilin results in increased activity of ESR1 protein | increases activity | 12504345 11750080 |
| C007610 | equol | equol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15876408 |
| C007610 | equol | equol binds to ESR1 protein | affects binding | 15993745 |
| C007610 | equol | equol results in increased activity of ESR1 protein | increases activity | 16118406 |
| C007610 | equol | Estradiol affects the reaction [equol affects the activity of ESR1 protein] | affects activity|affects reaction | 16965913 |
| C025483 | estradiol-17 beta-glucuronide | estradiol-17 beta-glucuronide binds to ESR1 protein | affects binding | 11944962 |
| C025483 | estradiol-17 beta-glucuronide | estradiol-17 beta-glucuronide binds to ESR1 protein | affects binding | 11944962 |
| C074283 | estradiol 3-benzoate | estradiol 3-benzoate binds to ESR1 protein | affects binding | 11162928 |
| C074283 | estradiol 3-benzoate | [boldenone undecylenate co-treated with estradiol 3-benzoate] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 16023321 |
| C074283 | estradiol 3-benzoate | [Testosterone co-treated with estradiol 3-benzoate] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 16023321 |
| C074283 | estradiol 3-benzoate | estradiol 3-benzoate binds to ESR1 protein | affects binding | 11162928 |
| C074283 | estradiol 3-benzoate | estradiol 3-benzoate binds to ESR1 protein | affects binding | 11162928 |
| C074283 | estradiol 3-benzoate | estradiol 3-benzoate binds to ESR1 protein | affects binding | 11162928 |
| C074283 | estradiol 3-benzoate | estradiol 3-benzoate binds to ESR1 protein | affects binding | 11162928 |
| C074283 | estradiol 3-benzoate | estradiol 3-benzoate affects the expression of ESR1 mRNA | affects expression | 15925091 19350480 |
| C074283 | estradiol 3-benzoate | estradiol 3-benzoate results in decreased expression of ESR1 | decreases expression | 15375486 |
| C074283 | estradiol 3-benzoate | estradiol 3-benzoate results in decreased expression of ESR1 protein | decreases expression | 15778002 |
| C074283 | estradiol 3-benzoate | estradiol 3-benzoate results in increased expression of ESR1 mRNA | increases expression | 15716488 |
| D004958 | Estradiol | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D004958 | Estradiol | alachlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D004958 | Estradiol | aroclor 1242 inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D004958 | Estradiol | Atrazine inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D004958 | Estradiol | Chlordecone inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D004958 | Estradiol | cyanazine inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D004958 | Estradiol | DDOH inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D004958 | Estradiol | DDT inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D004958 | Estradiol | Dichlorodiphenyl Dichloroethylene inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D004958 | Estradiol | Dicofol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D004958 | Estradiol | [Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D004958 | Estradiol | Endosulfan inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D004958 | Estradiol | Estradiol binds to ESR1 protein | affects binding | 9168004 |
| D004958 | Estradiol | Heptachlor Epoxide inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 12505301 |
| D004958 | Estradiol | Heptachlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 12505301 |
| D004958 | Estradiol | Mitotane inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D004958 | Estradiol | nonachlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D004958 | Estradiol | [o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9118873 |
| D004958 | Estradiol | [o,p'-DDT co-treated with Dicofol] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9118873 |
| D004958 | Estradiol | o,p'-DDT inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| D004958 | Estradiol | [Toxaphene co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D004958 | Estradiol | [Toxaphene co-treated with Dieldrin] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D004958 | Estradiol | Estradiol binds to ESR1 protein | affects binding | 11162928 |
| D004958 | Estradiol | Estradiol results in increased phosphorylation of ESR1 protein | increases phosphorylation | 15615701 |
| D004958 | Estradiol | Estradiol affects the expression of ESR1 protein | affects expression | 16483645 |
| D004958 | Estradiol | Estradiol results in increased activity of ESR1 protein | increases activity | 18980245 |
| D004958 | Estradiol | malachite green inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 18980245 |
| D004958 | Estradiol | Estradiol binds to ESR1 protein | affects binding | 11162928 |
| D004958 | Estradiol | Estradiol results in increased expression of ESR1 mRNA | increases expression | 19456386 |
| D004958 | Estradiol | Tamoxifen inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 19456386 |
| D004958 | Estradiol | 16 alpha-bromo-17 beta-estradiol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9751507 |
| D004958 | Estradiol | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | 22-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17873880 |
| D004958 | Estradiol | 2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 10964929 |
| D004958 | Estradiol | 24-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17873880 |
| D004958 | Estradiol | 25-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17873880 |
| D004958 | Estradiol | 27-hydroxycholesterol inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 17872378 |
| D004958 | Estradiol | 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17873880 |
| D004958 | Estradiol | 2-ethyl-4-(4-hydroxyphenyl)-5-(4-(2-piperidin-1-ylethoxy)phenyl)-2-imidazoline inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 15658860 |
| D004958 | Estradiol | 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 20861237 |
| D004958 | Estradiol | 4-hydroxytamoxifen inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9751507 11751013 |
| D004958 | Estradiol | 4-hydroxytamoxifen inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 15885261 |
| D004958 | Estradiol | 4-tert-octylphenol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 10964929 |
| D004958 | Estradiol | 6-deisopropylatrazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 8858116 |
| D004958 | Estradiol | Acetaminophen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to ESR1 protein]] | affects binding|decreases reaction|increases reaction | 15713566 |
| D004958 | Estradiol | AG 1879 inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein] | decreases reaction|increases phosphorylation | 15615701 |
| D004958 | Estradiol | [AHR protein binds to ESR1 protein] affects the reaction [Estradiol results in increased expression of BRCA1 mRNA] | affects binding|affects reaction|increases expression | 16489025 |
| D004958 | Estradiol | alachlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | Aldicarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 9126867 |
| D004958 | Estradiol | Aldrin inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | Apigenin inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | ARID5A protein inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 15941852 |
| D004958 | Estradiol | Atrazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 8858116 |
| D004958 | Estradiol | Atrazine inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | bendiocarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 9126867 |
| D004958 | Estradiol | Benomyl inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | benz(a)anthracene promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 12441364 |
| D004958 | Estradiol | Benzo(a)pyrene promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 12441364 |
| D004958 | Estradiol | beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17051425 |
| D004958 | Estradiol | biochanin A inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | bisphenol A inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 11530281 |
| D004958 | Estradiol | bisphenol A inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 10964929 11258963 9751507 |
| D004958 | Estradiol | BRCA1 protein affects the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]] | affects binding|affects reaction|increases reaction | 18997820 |
| D004958 | Estradiol | BRCA1 protein promotes the reaction [indole-3-carbinol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity|increases reaction | 11110848 |
| D004958 | Estradiol | Butylated Hydroxyanisole inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 12822488 |
| D004958 | Estradiol | Butyrophenones inhibits the reaction [[Estradiol results in increased activity of ESR1 protein] which results in increased expression of CCND1 mRNA] | decreases reaction|increases activity|increases expression | 21041310 |
| D004958 | Estradiol | Butyrophenones inhibits the reaction [[Estradiol results in increased activity of ESR1 protein] which results in increased expression of SERPINB9 mRNA] | decreases reaction|increases activity|increases expression | 21041310 |
| D004958 | Estradiol | Carbaryl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 9126867 |
| D004958 | Estradiol | CCND1 protein promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 16328721 |
| D004958 | Estradiol | Chlordecone inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9751507 14579009 15253041 |
| D004958 | Estradiol | Coumestrol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 16566672 |
| D004958 | Estradiol | Curcumin inhibits the reaction [Estradiol results in increased degradation of ESR1 protein] | decreases reaction|increases degradation | 15899841 |
| D004958 | Estradiol | Curcumin inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein] | decreases reaction|increases phosphorylation | 15899841 |
| D004958 | Estradiol | cyanazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 8858116 |
| D004958 | Estradiol | daidzein inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | daidzein promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 16118406 |
| D004958 | Estradiol | Dichlorodiphenyl Dichloroethylene inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | [Dieldrin co-treated with alachlor] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D004958 | Estradiol | [Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D004958 | Estradiol | Dieldrin inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | Dieldrin inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA] | decreases expression|decreases reaction | 15261991 |
| D004958 | Estradiol | Diethylstilbestrol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 10964929 9751507 |
| D004958 | Estradiol | dong quai inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 11368622 |
| D004958 | Estradiol | Endosulfan inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | ESR1 gene polymorphism affects the abundance of Estradiol | affects abundance | 16061840 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to CECR6 gene]] | affects binding|affects reaction|increases reaction | 17962382 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to H19 gene]] | affects binding|affects reaction|increases reaction | 17962382 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to LLGL2 gene]] | affects binding|affects reaction|increases reaction | 17962382 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to CECR6 gene]] | affects binding|affects reaction|increases reaction | 17962382 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to H19 gene]] | affects binding|affects reaction|increases reaction | 17962382 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to KLRC1 gene]] | affects binding|affects reaction|increases reaction | 17962382 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to LLGL2 gene]] | affects binding|affects reaction|increases reaction | 17962382 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to NKD1 gene]] | affects binding|affects reaction|increases reaction | 17962382 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to CECR6 gene]] | affects binding|affects reaction|increases reaction | 17962382 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to H19 gene]] | affects binding|affects reaction|increases reaction | 17962382 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to KLRC1 gene]] | affects binding|affects reaction|increases reaction | 17962382 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to NKD1 gene]] | affects binding|affects reaction|increases reaction | 17962382 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to SPATA13 gene]] | affects binding|affects reaction|increases reaction | 17962382 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in decreased activity of CCL2 protein] | affects reaction|decreases activity | 17006379 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in decreased expression of ABCB1 protein] | affects reaction|decreases expression | 16925584 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in decreased expression of ATP2A3 mRNA] | affects reaction|decreases expression | 15223131 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in decreased expression of CEACAM3 mRNA] | affects reaction|decreases expression | 15223131 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in decreased expression of EIF5A mRNA] | affects reaction|decreases expression | 15223131 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in decreased expression of ELAC2 mRNA] | affects reaction|decreases expression | 15223131 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in decreased expression of EMP1 mRNA] | affects reaction|decreases expression | 14699072 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in decreased expression of ETFB mRNA] | affects reaction|decreases expression | 15223131 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in decreased expression of HAS2 mRNA] | affects reaction|decreases expression | 14699072 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in decreased expression of MIR21 mRNA] | affects reaction|decreases expression | 19264808 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in decreased expression of PTPRO mRNA] | affects reaction|decreases expression | 15223131 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in decreased expression of SEC16A mRNA] | affects reaction|decreases expression | 15223131 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of AGT mRNA] | affects reaction|increases expression | 14699072 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of BCL2 mRNA] | affects reaction|increases expression | 19264808 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of BCL2 protein] | affects reaction|increases expression | 19264808 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of CCKBR mRNA] | affects reaction|increases expression | 15223131 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of GPR176 mRNA] | affects reaction|increases expression | 14699072 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of HSPCB mRNA] | affects reaction|increases expression | 15223131 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of KLRC3 mRNA] | affects reaction|increases expression | 17395694 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of KRT19 mRNA] | affects reaction|increases expression | 14699072 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of PDCD4 mRNA] | affects reaction|increases expression | 19264808 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of PDCD4 protein] | affects reaction|increases expression | 19264808 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of PIP5K1A mRNA] | affects reaction|increases expression | 15223131 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of PTEN mRNA] | affects reaction|increases expression | 19264808 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of PTEN protein] | affects reaction|increases expression | 19264808 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of SERPINA1 mRNA] | affects reaction|increases expression | 14699072 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of TGM2 mRNA] | affects reaction|increases expression | 14699072 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of WISP2 mRNA] | affects reaction|increases expression | 14699072 |
| D004958 | Estradiol | ESR1 protein affects the susceptibility to Estradiol | affects response to substance | 17275032 |
| D004958 | Estradiol | ESR1 protein alternative form inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA] | decreases expression|decreases reaction | 20302909 |
| D004958 | Estradiol | ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA] | decreases reaction|increases expression | 20302909 |
| D004958 | Estradiol | ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of NRF1 mRNA] | decreases reaction|increases expression | 20302909 |
| D004958 | Estradiol | ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of PDCD4 mRNA] | decreases reaction|increases expression | 20302909 |
| D004958 | Estradiol | ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of PDCD4 protein] | decreases reaction|increases expression | 20302909 |
| D004958 | Estradiol | ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of PGR mRNA] | decreases reaction|increases expression | 20302909 |
| D004958 | Estradiol | ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of PTEN mRNA] | decreases reaction|increases expression | 20302909 |
| D004958 | Estradiol | ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of PTEN protein] | decreases reaction|increases expression | 20302909 |
| D004958 | Estradiol | ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA] | decreases reaction|increases expression | 20302909 |
| D004958 | Estradiol | ESR1 protein promotes the reaction [Estradiol inhibits the reaction [Potassium results in increased secretion of gamma-Aminobutyric Acid]] | decreases reaction|increases reaction|increases secretion | 19211896 |
| D004958 | Estradiol | ESR1 protein promotes the reaction [Estradiol results in increased expression of AGER protein] | increases expression|increases reaction | 15878629 |
| D004958 | Estradiol | ESR1 protein promotes the reaction [Estradiol results in increased expression of CYP2A6 mRNA] | increases expression|increases reaction | 17646279 |
| D004958 | Estradiol | ESR1 protein promotes the reaction [Estradiol results in increased expression of DMBT1 mRNA] | increases expression|increases reaction | 15564322 |
| D004958 | Estradiol | ESR1 protein promotes the reaction [Estradiol results in increased expression of FOXM1 mRNA] | increases expression|increases reaction | 20208560 |
| D004958 | Estradiol | ESR1 protein promotes the reaction [Estradiol results in increased expression of FOXM1 protein] | increases expression|increases reaction | 20208560 |
| D004958 | Estradiol | ESR1 protein promotes the reaction [Estradiol results in increased expression of SERPINB9 mRNA] | increases expression|increases reaction | 17237823 |
| D004958 | Estradiol | ESR1 protein promotes the reaction [Estradiol results in increased phosphorylation of MAPK1 protein] | increases phosphorylation|increases reaction | 20372779 |
| D004958 | Estradiol | ESR1 protein promotes the reaction [Estradiol results in increased phosphorylation of MAPK3 protein] | increases phosphorylation|increases reaction | 20372779 |
| D004958 | Estradiol | ESR2 affects the reaction [Estradiol affects the expression of ESR1 mRNA] | affects expression|affects reaction | 19434490 |
| D004958 | Estradiol | Estradiol affects the activity of ESR1 protein | affects activity | 18635651 |
| D004958 | Estradiol | Estradiol affects the localization of ESR1 protein | affects localization | 16061635 15947004 |
| D004958 | Estradiol | Estradiol affects the reaction [daidzein metabolite affects the activity of ESR1 protein] | affects activity|affects reaction | 16965913 |
| D004958 | Estradiol | Estradiol affects the reaction [equol affects the activity of ESR1 protein] | affects activity|affects reaction | 16965913 |
| D004958 | Estradiol | Estradiol affects the reaction [kaempferol results in increased activity of ESR1 protein] | affects reaction|increases activity | 16118406 |
| D004958 | Estradiol | Estradiol affects the reaction [O-desmethylangolensin affects the activity of ESR1 protein] | affects activity|affects reaction | 16965913 |
| D004958 | Estradiol | Estradiol affects the reaction [Quercetin results in increased activity of ESR1 protein] | affects reaction|increases activity | 16118406 |
| D004958 | Estradiol | Estradiol affects the reaction [tetrahydrodaidzein affects the activity of ESR1 protein] | affects activity|affects reaction | 16965913 |
| D004958 | Estradiol | Estradiol analog binds to ESR1 protein | affects binding | 16728493 |
| D004958 | Estradiol | Estradiol analog results in increased activity of ESR1 protein | increases activity | 11331656 |
| D004958 | Estradiol | Estradiol binds to and affects the folding of and results in increased activity of ESR1 protein | affects binding|affects folding|increases activity | 17872378 |
| D004958 | Estradiol | Estradiol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 19666091 15120416 10397250 11530281 20332105 20427257 16337670 17873880 8858116 14709801 15937998 15876408 12676605 20211987 11174852 15026083 16079615 |
| D004958 | Estradiol | [Estradiol binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA | affects binding|increases activity|increases expression | 11174852 |
| D004958 | Estradiol | Estradiol binds to ESR1 protein | affects binding | 14579009 16037132 9751507 15961563 15946813 12822488 17400923 10964929 15833885 16728493 12021401 11518614 11368622 9168004 16839579 11162928 15955695 17203231 16024245 11258963 15521089 |
| D004958 | Estradiol | [Estradiol binds to ESR1 protein] which affects the folding of ESR1 protein | affects binding|affects folding | 16216903 |
| D004958 | Estradiol | [Estradiol binds to ESR1 protein] which binds to NCOA2 protein | affects binding | 15123288 |
| D004958 | Estradiol | [Estradiol binds to ESR1 protein] which results in decreased expression of ABCG2 | affects binding|decreases expression | 15695404 |
| D004958 | Estradiol | [Estradiol binds to ESR1 protein] which results in increased activity of ALPL protein | affects binding|increases activity | 12650720 |
| D004958 | Estradiol | [Estradiol co-treated with ESR1 protein] results in decreased expression of EGFR mRNA | affects cotreatment|decreases expression | 19347870 |
| D004958 | Estradiol | [Estradiol co-treated with ESR1 protein] results in decreased expression of EGFR protein | affects cotreatment|decreases expression | 19347870 |
| D004958 | Estradiol | [Estradiol co-treated with ESR1 protein] results in increased expression of BGLAP mRNA | affects cotreatment|increases expression | 19347870 |
| D004958 | Estradiol | [Estradiol co-treated with ESR1 protein] results in increased expression of BSP mRNA | affects cotreatment|increases expression | 19347870 |
| D004958 | Estradiol | [Estradiol co-treated with ESR1 protein] results in increased expression of IGFBP4 mRNA | affects cotreatment|increases expression | 12399409 |
| D004958 | Estradiol | [Estradiol co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA | affects cotreatment|increases expression | 19351862 |
| D004958 | Estradiol | [Estradiol co-treated with ESR1 protein] results in increased expression of NOS3 mRNA | affects cotreatment|increases expression | 14742696 |
| D004958 | Estradiol | [Estradiol co-treated with ESR1 protein] results in increased expression of PTGS2 mRNA | affects cotreatment|increases expression | 19347870 |
| D004958 | Estradiol | [Estradiol co-treated with ESR1 protein] results in increased phosphorylation of MAPK1 protein | affects cotreatment|increases phosphorylation | 15185748 |
| D004958 | Estradiol | [Estradiol co-treated with fulvestrant co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA | affects cotreatment|increases expression | 19351862 |
| D004958 | Estradiol | [Estradiol co-treated with Genistein co-treated with o,p'-DDT] affects the expression of ESR1 mRNA | affects cotreatment|affects expression | 11922773 |
| D004958 | Estradiol | [Estradiol co-treated with Tamoxifen co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA | affects cotreatment|increases expression | 19351862 |
| D004958 | Estradiol | [Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [ESR1 protein binds to CYP1A1 enhancer] | affects binding|affects cotreatment|increases reaction | 15837795 |
| D004958 | Estradiol | Estradiol inhibits the reaction [ESR1 protein binds to PHB2 protein] | affects binding|decreases reaction | 18997820 |
| D004958 | Estradiol | Estradiol inhibits the reaction [ESR1 protein binds to STUB1 protein] | affects binding|decreases reaction | 16037132 |
| D004958 | Estradiol | Estradiol inhibits the reaction [royal jelly binds to ESR1 protein] | affects binding|decreases reaction | 17287592 |
| D004958 | Estradiol | Estradiol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CAD promoter]] | affects binding|decreases reaction|increases reaction | 16675542 |
| D004958 | Estradiol | Estradiol metabolite binds to ESR1 protein | affects binding | 16728493 |
| D004958 | Estradiol | Estradiol promotes the reaction [CREBBP protein binds to ESR1 promoter] | affects binding|increases reaction | 19620290 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to ADORA1 promoter] | affects binding|increases reaction | 19698761 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to AGR2 promoter] | affects binding|increases reaction | 20531310 |
| D004958 | Estradiol | Estradiol promotes the reaction [[ESR1 protein binds to AGR2 promoter] which results in increased expression of AGR2 mRNA] | affects binding|increases expression|increases reaction | 20531310 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to AGT promoter] | affects binding|increases reaction | 19698761 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to AICDA promoter] | affects binding|increases reaction | 19139166 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to BRCA1 promoter] | affects binding|increases reaction | 16489025 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to CDKN1A promoter] | affects binding|increases reaction | 20696891 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to CEBPB protein] | affects binding|increases reaction | 17395694 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to CECR6 gene] | affects binding|increases reaction | 17962382 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to CREBBP protein binds to BRCA1 protein] | affects binding|increases reaction | 16417649 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to CTSD promoter] | affects binding|increases reaction | 19698761 |
| D004958 | Estradiol | Estradiol promotes the reaction [[ESR1 protein binds to CTSD promoter] which results in increased expression of CTSD mRNA] | affects binding|increases expression|increases reaction | 11165043 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to CYP2A6 promoter] | affects binding|increases reaction | 17646279 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to ESR1 promoter] | affects binding|increases reaction | 19620290 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to ESR1 protein] | affects binding|increases reaction | 15713566 20061804 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to ESR2 protein] | affects binding|increases reaction | 20061804 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to FOXM1 promoter] | affects binding|increases reaction | 20208560 |
| D004958 | Estradiol | Estradiol promotes the reaction [[ESR1 protein binds to FOXM1 promoter] which results in increased expression of FOXM1 mRNA] | affects binding|increases expression|increases reaction | 20208560 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to GREB1 enhancer] | affects binding|increases reaction | 20068169 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to H19 gene] | affects binding|increases reaction | 17962382 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to HOXA10 gene] | affects binding|increases reaction | 15890768 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to HOXA10 promoter] | affects binding|increases reaction | 15236964 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to HSF2 protein] | affects binding|increases reaction | 17395694 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to HSPB1 promoter] | affects binding|increases reaction | 11174852 19698761 |
| D004958 | Estradiol | Estradiol promotes the reaction [[ESR1 protein binds to HSPB1 promoter] which results in increased expression of HSPB1 mRNA] | affects binding|increases expression|increases reaction | 11174852 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to IGF1 promoter] | affects binding|increases reaction | 17872375 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to IGF1R protein] | affects binding|increases reaction | 19815064 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to JUN protein] | affects binding|increases reaction | 17395694 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to KLRC1 gene] | affects binding|increases reaction | 17962382 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to KLRC3 gene] | affects binding|increases reaction | 17395694 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to LCN2 promoter] | affects binding|increases reaction | 19698761 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to LLGL2 gene] | affects binding|increases reaction | 17962382 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to MYC promoter] | affects binding|increases reaction | 19698761 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein] | affects binding|increases reaction | 10964929 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to NCOA2 protein] | affects binding|increases reaction | 10964929 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein] | affects binding|increases reaction | 18997820 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to NKD1 gene] | affects binding|increases reaction | 17962382 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to PTGS2 promoter] | affects binding|increases reaction | 17872375 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to RORA promoter] | affects binding|increases reaction | 21359227 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to SERPINB9 protein] | affects binding|increases reaction | 14617632 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to SOCS3 promoter] | affects binding|increases reaction | 16055089 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to SP1 protein] | affects binding|increases reaction | 16675542 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to SPATA13 gene] | affects binding|increases reaction | 17962382 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter] | affects binding|increases reaction | 16972788 17872378 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to TFF1 protein] | affects binding|increases reaction | 14617632 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to TFF2 promoter] | affects binding|increases reaction | 20696891 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to TTF1 promoter] | affects binding|increases reaction | 19698761 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to XBP1 enhancer] | affects binding|increases reaction | 20068169 |
| D004958 | Estradiol | Estradiol promotes the reaction [FHL2 protein binds to ESR1 protein] | affects binding|increases reaction | 15666801 |
| D004958 | Estradiol | Estradiol promotes the reaction [NCOA1 protein binds to ESR1 protein] | affects binding|increases reaction | 17135255 |
| D004958 | Estradiol | Estradiol promotes the reaction [NCOA2 protein binds to ESR1 protein] | affects binding|increases reaction | 15084758 |
| D004958 | Estradiol | Estradiol promotes the reaction [NCOA3 protein binds to ESR1 promoter] | affects binding|increases reaction | 19620290 |
| D004958 | Estradiol | Estradiol promotes the reaction [PIAS1 protein binds to ESR1 protein] | affects binding|increases reaction | 15666801 |
| D004958 | Estradiol | Estradiol promotes the reaction [SHC1 protein binds to ESR1 protein] | affects binding|increases reaction | 16024245 |
| D004958 | Estradiol | Estradiol promotes the reaction [SIN3A protein binds to ESR1 promoter] | affects binding|increases reaction | 19620290 |
| D004958 | Estradiol | Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]] | affects binding|increases reaction | 16675542 |
| D004958 | Estradiol | Estradiol promotes the reaction [UBE2I protein binds to ESR1 protein] | affects binding|increases reaction | 15666801 |
| D004958 | Estradiol | Estradiol results in decreased expression of ESR1 mRNA | decreases expression | 16029874 12822488 15219790 19620290 15130599 14709801 16393665 15261991 19942988 |
| D004958 | Estradiol | Estradiol results in decreased expression of ESR1 protein | decreases expression | 15118252 19815064 17904202 19288272 14709801 18997820 12948864 14754635 16202921 19416221 17125913 12753421 11867264 16739346 |
| D004958 | Estradiol | Estradiol results in increased activity of and results in increased localization of ESR1 protein | increases activity|increases localization | 14754635 |
| D004958 | Estradiol | Estradiol results in increased activity of ESR1 protein | increases activity | 18028983 15885261 19339991 17141713 15103026 12441364 20204298 12623674 16328721 12558164 19161236 16434996 16118406 16055089 16029874 20360387 9846162 17935960 21041310 20008677 17266178 16756374 18486176 15064155 20061804 11335189 11875334 |
| D004958 | Estradiol | [Estradiol results in increased activity of ESR1 protein] which results in increased expression of CCND1 mRNA | increases activity|increases expression | 21041310 |
| D004958 | Estradiol | [Estradiol results in increased activity of ESR1 protein] which results in increased expression of SERPINB9 mRNA | increases activity|increases expression | 21041310 |
| D004958 | Estradiol | Estradiol results in increased degradation of ESR1 protein | increases degradation | 15899841 17872378 |
| D004958 | Estradiol | Estradiol results in increased expression of ESR1 mRNA | increases expression | 11922773 19432593 15968319 12737316 12377985 16076840 |
| D004958 | Estradiol | Estradiol results in increased expression of ESR1 protein | increases expression | 14999240 20103631 |
| D004958 | Estradiol | Estradiol results in increased phosphorylation of ESR1 protein | increases phosphorylation | 12441364 15615701 20103631 15899841 16076840 18997820 |
| D004958 | Estradiol | Estradiol results in increased phosphorylation of ESR1 protein alternative form | increases phosphorylation | 15913882 |
| D004958 | Estradiol | FKBPL protein inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein] | decreases reaction|increases phosphorylation | 20103631 |
| D004958 | Estradiol | fluoranthene promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 12441364 |
| D004958 | Estradiol | FOXA1 protein affects the reaction [Estradiol affects the activity of ESR1 protein] | affects activity|affects reaction | 21151129 |
| D004958 | Estradiol | fulvestrant inhibits the reaction [benz(a)anthracene promotes the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity|increases reaction | 12441364 |
| D004958 | Estradiol | fulvestrant inhibits the reaction [Benzo(a)pyrene promotes the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity|increases reaction | 12441364 |
| D004958 | Estradiol | fulvestrant inhibits the reaction [[Estradiol binds to ESR1 protein] which results in increased activity of ALPL protein] | affects binding|decreases reaction|increases activity | 12650720 |
| D004958 | Estradiol | fulvestrant inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased expression of NOS3 mRNA] | affects cotreatment|decreases reaction|increases expression | 14742696 |
| D004958 | Estradiol | fulvestrant inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA] | decreases expression|decreases reaction | 19620290 15130599 |
| D004958 | Estradiol | fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 20061804 12441364 17872378 |
| D004958 | Estradiol | fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 16076840 |
| D004958 | Estradiol | fulvestrant inhibits the reaction [fluoranthene promotes the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity|increases reaction | 12441364 |
| D004958 | Estradiol | geldanamycin inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 11448926 |
| D004958 | Estradiol | Genistein inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 16566672 14579009 10964929 11368622 |
| D004958 | Estradiol | Genistein inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 16434996 |
| D004958 | Estradiol | Genistein promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 16118406 |
| D004958 | Estradiol | glyceollin inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 19797619 |
| D004958 | Estradiol | glycitein inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | GW 7604 analog inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17033922 |
| D004958 | Estradiol | GW 7604 inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17033922 |
| D004958 | Estradiol | indole-3-carbinol inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 11110848 16434996 |
| D004958 | Estradiol | kaempferol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | KRT18 protein promotes the reaction [fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity|increases reaction | 20061804 |
| D004958 | Estradiol | KRT8 protein promotes the reaction [fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity|increases reaction | 20061804 |
| D004958 | Estradiol | leptomycin B inhibits the reaction [Estradiol results in increased degradation of ESR1 protein] | decreases reaction|increases degradation | 15899841 |
| D004958 | Estradiol | Lindane inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | Lithium Chloride inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 16076840 |
| D004958 | Estradiol | Lithium Chloride inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein] | decreases reaction|increases phosphorylation | 16076840 |
| D004958 | Estradiol | Luteolin inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | lycopene inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17051425 |
| D004958 | Estradiol | Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 15813899 |
| D004958 | Estradiol | Methomyl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 9126867 |
| D004958 | Estradiol | methoxyacetic acid promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 15103026 18486176 |
| D004958 | Estradiol | Methoxychlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9751507 14579009 |
| D004958 | Estradiol | Methoxychlor inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to HOXA10 gene]] | affects binding|decreases reaction|increases reaction | 15890768 |
| D004958 | Estradiol | methylselenic acid inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 15833885 |
| D004958 | Estradiol | Mitotane inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 8930550 |
| D004958 | Estradiol | [NCOA1 protein binds to ESR1 protein] which results in increased susceptibility to Estradiol | affects binding|increases response to substance | 20332105 |
| D004958 | Estradiol | NCOA2 protein promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 16328721 |
| D004958 | Estradiol | nonachlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | nonylphenol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | o,p'-DDT inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 8930550 14579009 |
| D004958 | Estradiol | oxamyl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 9126867 |
| D004958 | Estradiol | PD 98059 inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein] | decreases reaction|increases phosphorylation | 15615701 |
| D004958 | Estradiol | Pertussis Toxin inhibits the reaction [Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity | 15813899 |
| D004958 | Estradiol | phthalic acid analog inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | [phytoene co-treated with phytofluene] inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | affects cotreatment|decreases reaction|increases activity | 17051425 |
| D004958 | Estradiol | Plant Extracts inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 16566672 11368622 |
| D004958 | Estradiol | Polychlorinated Biphenyls metabolite inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 12377985 |
| D004958 | Estradiol | prochloraz inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA] | decreases expression|decreases reaction | 15261991 |
| D004958 | Estradiol | Propoxur inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 9126867 |
| D004958 | Estradiol | pyridate inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 15253041 |
| D004958 | Estradiol | Raloxifene inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9751507 |
| D004958 | Estradiol | resveratrol promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 16118406 |
| D004958 | Estradiol | royal jelly inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 15946813 |
| D004958 | Estradiol | Simazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 8858116 |
| D004958 | Estradiol | [Tamoxifen co-treated with Estradiol] results in decreased expression of ESR1 mRNA | affects cotreatment|decreases expression | 19434490 |
| D004958 | Estradiol | Tamoxifen inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 12676605 |
| D004958 | Estradiol | Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to AICDA promoter]] | affects binding|decreases reaction|increases reaction | 19139166 |
| D004958 | Estradiol | Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to ESR1 protein]] | affects binding|decreases reaction|increases reaction | 15713566 |
| D004958 | Estradiol | Tamoxifen inhibits the reaction [Estradiol promotes the reaction [[ESR1 protein binds to FOXM1 promoter] which results in increased expression of FOXM1 mRNA]] | affects binding|decreases reaction|increases expression|increases reaction | 20208560 |
| D004958 | Estradiol | Tamoxifen inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA] | decreases expression|decreases reaction | 19942988 |
| D004958 | Estradiol | Tamoxifen inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 20061804 16328721 20204298 |
| D004958 | Estradiol | Tamoxifen inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 12377985 |
| D004958 | Estradiol | Tamoxifen promotes the reaction [Estradiol results in increased activity of ESR1 protein mutant form] | increases activity|increases reaction | 16328721 |
| D004958 | Estradiol | TBX21 protein inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to GREB1 enhancer]] | affects binding|decreases reaction|increases reaction | 20068169 |
| D004958 | Estradiol | TBX21 protein inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to XBP1 enhancer]] | affects binding|decreases reaction|increases reaction | 20068169 |
| D004958 | Estradiol | [Tetrachlorodibenzodioxin co-treated with Estradiol] promotes the reaction [ESR1 protein binds to CYP1A1 promoter] | affects binding|affects cotreatment|increases reaction | 15964790 |
| D004958 | Estradiol | Tetrachlorodibenzodioxin inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 12021401 |
| D004958 | Estradiol | Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to SP1 protein]] | affects binding|decreases reaction|increases reaction | 16675542 |
| D004958 | Estradiol | Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in decreased expression of ESR1 protein] | decreases expression|decreases reaction | 19416221 |
| D004958 | Estradiol | [Toxaphene co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D004958 | Estradiol | [Toxaphene co-treated with Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D004958 | Estradiol | Toxaphene inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | tri-(2-ethylhexyl)trimellitate promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 16756374 |
| D004958 | Estradiol | triclocarban analog promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 18795164 |
| D004958 | Estradiol | triclocarban promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 18795164 |
| D004958 | Estradiol | Triclosan inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 17992702 |
| D004958 | Estradiol | Triclosan inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 18795164 |
| D004958 | Estradiol | vinclozolin inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D004958 | Estradiol | ZNF366 protein inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 20008677 |
| D004958 | Estradiol | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| D004958 | Estradiol | beta-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| D004958 | Estradiol | Chlordecone inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| D004958 | Estradiol | Diethylstilbestrol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| D004958 | Estradiol | Estradiol binds to ESR1 protein | affects binding | 9439733 |
| D004958 | Estradiol | Estradiol results in increased expression of ESR1 protein | increases expression | 9439733 |
| D004958 | Estradiol | Ethinyl Estradiol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| D004958 | Estradiol | Mestranol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| D004958 | Estradiol | Methoxychlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| D004958 | Estradiol | nonylphenol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| D004958 | Estradiol | o,p'-DDT inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| D004958 | Estradiol | Tamoxifen inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| D004958 | Estradiol | Estradiol binds to ESR1 protein | affects binding | 15001543 |
| D004958 | Estradiol | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Estradiol results in decreased expression of ESR1 protein] | decreases expression|decreases reaction | 16055746 |
| D004958 | Estradiol | bu-zhong-yi-qi-tang inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 17089059 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in decreased expression of CYP17A1 mRNA] | affects reaction|decreases expression | 17158782 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of G6PDX mRNA] | affects reaction|increases expression | 10433208 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of INS2 protein] | affects reaction|increases expression | 18446233 |
| D004958 | Estradiol | ESR1 protein affects the reaction [Estradiol results in increased expression of LTF mRNA] | affects reaction|increases expression | 10433208 |
| D004958 | Estradiol | ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA] | increases expression|increases reaction | 17974624 |
| D004958 | Estradiol | Estradiol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 20209442 |
| D004958 | Estradiol | Estradiol binds to ESR1 protein | affects binding | 11162928 |
| D004958 | Estradiol | [Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of ESR1 mRNA | affects cotreatment|decreases expression | 11509743 |
| D004958 | Estradiol | [Estradiol co-treated with bisindolylmaleimide I] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 12927369 |
| D004958 | Estradiol | [Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of ESR1 mRNA | affects cotreatment|decreases expression | 11509743 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to FOS promoter] | affects binding|increases reaction | 17991765 |
| D004958 | Estradiol | Estradiol results in decreased expression of ESR1 mRNA | decreases expression | 11509743 16985261 |
| D004958 | Estradiol | Estradiol results in decreased expression of ESR1 protein | decreases expression | 15916834 12927369 16055746 |
| D004958 | Estradiol | Estradiol results in increased activity of ESR1 protein | increases activity | 18446233 19495926 |
| D004958 | Estradiol | Estradiol results in increased expression of ESR1 mRNA | increases expression | 16280380 8829249 19340542 17089059 16606610 10825672 |
| D004958 | Estradiol | Estradiol results in increased expression of ESR1 protein | increases expression | 15541753 19340542 15916834 |
| D004958 | Estradiol | fulvestrant inhibits the reaction [ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]] | decreases reaction|increases expression|increases reaction | 17974624 |
| D004958 | Estradiol | fulvestrant inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 20209442 |
| D004958 | Estradiol | fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 16280380 |
| D004958 | Estradiol | fulvestrant promotes the reaction [Estradiol results in increased expression of ESR1 protein] | increases expression|increases reaction | 19340542 |
| D004958 | Estradiol | PD 98059 inhibits the reaction [Estradiol results in increased expression of ESR1 protein] | decreases reaction|increases expression | 19340542 |
| D004958 | Estradiol | Progesterone inhibits the reaction [ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]] | decreases reaction|increases expression|increases reaction | 17974624 |
| D004958 | Estradiol | SB 203580 inhibits the reaction [Estradiol results in increased expression of ESR1 protein] | decreases reaction|increases expression | 19340542 |
| D004958 | Estradiol | Tamoxifen promotes the reaction [Estradiol results in increased expression of ESR1 protein] | increases expression|increases reaction | 19340542 |
| D004958 | Estradiol | Tetradecanoylphorbol Acetate promotes the reaction [Estradiol results in increased expression of ESR1 protein] | increases expression|increases reaction | 19340542 |
| D004958 | Estradiol | Toremifene inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 12079510 |
| D004958 | Estradiol | Toremifene inhibits the reaction [Estradiol results in increased expression of ESR1 protein] | decreases reaction|increases expression | 12079510 |
| D004958 | Estradiol | Estradiol analog results in increased activity of ESR1 protein | increases activity | 11331656 |
| D004958 | Estradiol | Estradiol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 18348622 12206426 9460653 |
| D004958 | Estradiol | Estradiol binds to ESR1 protein | affects binding | 11162928 11944962 |
| D004958 | Estradiol | [Estradiol co-treated with Tamoxifen] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 17823450 |
| D004958 | Estradiol | Estradiol results in increased expression of ESR1 mRNA | increases expression | 18709148 17823450 |
| D004958 | Estradiol | Estradiol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15994857 |
| D004958 | Estradiol | Methoxychlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9171990 |
| D004958 | Estradiol | nonylphenol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9171990 |
| D004958 | Estradiol | o,p'-DDT inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9171990 |
| D004958 | Estradiol | Pentachlorophenol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9171990 |
| D004958 | Estradiol | Estradiol results in increased expression of ESR1 mRNA | increases expression | 17327697 |
| D004958 | Estradiol | [Progesterone co-treated with Estradiol] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 15829624 |
| D004958 | Estradiol | Estradiol promotes the reaction [[ESR1 protein binds to VEGFA promoter] which results in increased expression of VEGFA mRNA] | affects binding|increases expression|increases reaction | 15774498 |
| D004958 | Estradiol | alpha-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 10580743 |
| D004958 | Estradiol | Atrazine inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 15056801 |
| D004958 | Estradiol | bisphenol A inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 10580743 15204698 |
| D004958 | Estradiol | bisphenol A inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ESR1 protein] | affects cotreatment|decreases reaction|increases expression | 18653720 |
| D004958 | Estradiol | butylparaben inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 15204698 |
| D004958 | Estradiol | dibromoacetic acid inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 10580743 |
| D004958 | Estradiol | Diethylstilbestrol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 15204698 |
| D004958 | Estradiol | Diethylstilbestrol inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ESR1 protein] | affects cotreatment|decreases reaction|increases expression | 18653720 |
| D004958 | Estradiol | Estradiol affects the activity of ESR1 protein | affects activity | 15746884 |
| D004958 | Estradiol | Estradiol binds to ESR1 protein | affects binding | 9492041 11086226 15458795 |
| D004958 | Estradiol | [Estradiol co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of ESR1 protein | affects cotreatment|decreases expression | 16891317 |
| D004958 | Estradiol | [Estradiol co-treated with ormeloxifene] promotes the reaction [NCOR1 protein binds to ESR1 protein] | affects binding|affects cotreatment|increases reaction | 19460436 |
| D004958 | Estradiol | [Estradiol co-treated with ormeloxifene] promotes the reaction [NRIP1 protein binds to ESR1 protein] | affects binding|affects cotreatment|increases reaction | 19460436 |
| D004958 | Estradiol | [Estradiol co-treated with ormeloxifene] results in decreased expression of ESR1 protein | affects cotreatment|decreases expression | 19460436 |
| D004958 | Estradiol | [Estradiol co-treated with Progesterone] results in decreased expression of ESR1 mRNA alternative form | affects cotreatment|decreases expression | 16002535 |
| D004958 | Estradiol | [Estradiol co-treated with Progesterone] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 18653720 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein] | affects binding|increases reaction | 19460436 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR2 protein alternative form binds to ESR1 protein] | affects binding|increases reaction | 9492041 |
| D004958 | Estradiol | Estradiol results in decreased expression of ESR1 mRNA | decreases expression | 16414171 20144698 18790044 15070829 16002535 |
| D004958 | Estradiol | Estradiol results in decreased expression of ESR1 mRNA alternative form | decreases expression | 16002535 |
| D004958 | Estradiol | Estradiol results in decreased expression of ESR1 protein | decreases expression | 16002535 16607101 19460436 18790044 |
| D004958 | Estradiol | Estradiol results in increased activity of ESR1 protein | increases activity | 15901789 12504345 17174995 11750080 |
| D004958 | Estradiol | Estradiol results in increased expression of ESR1 mRNA | increases expression | 17589598 12062901 14716833 |
| D004958 | Estradiol | Estradiol results in increased phosphorylation of ESR1 protein | increases phosphorylation | 17323972 |
| D004958 | Estradiol | Genistein inhibits the reaction [Estradiol affects the expression of ESR1 mRNA] | affects expression|decreases reaction | 17049845 |
| D004958 | Estradiol | Methoxychlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 10580743 |
| D004958 | Estradiol | Mitotane inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 10580743 |
| D004958 | Estradiol | ormeloxifene inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]] | affects binding|decreases reaction|increases reaction | 19460436 |
| D004958 | Estradiol | Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]] | affects binding|decreases reaction|increases reaction | 19460436 |
| D004958 | Estradiol | TS 108 inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 15671561 |
| D004958 | Estradiol | Estradiol results in increased activity of ESR1 protein | increases activity | 17539551 |
| D004958 | Estradiol | Estradiol binds to ESR1 protein | affects binding | 11944962 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to ESR1 protein] | affects binding|increases reaction | 15891078 |
| D004958 | Estradiol | Estradiol promotes the reaction [ESR1 protein binds to ESR2 protein] | affects binding|increases reaction | 15891078 |
| D004958 | Estradiol | Estradiol binds to ESR1 protein | affects binding | 19303142 |
| D004958 | Estradiol | Estradiol affects the expression of ESR1 protein | affects expression | 15653758 16680078 |
| D004958 | Estradiol | Estradiol results in decreased expression of ESR1 protein | decreases expression | 16431846 |
| D004958 | Estradiol | Estradiol results in decreased expression of ESR1 protein alternative form | decreases expression | 17348974 |
| D004958 | Estradiol | Estradiol results in increased expression of ESR1 mRNA | increases expression | 17258427 |
| D004958 | Estradiol | Estradiol results in increased expression of ESR1 mRNA | increases expression | 16198636 |
| D004958 | Estradiol | 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 20686605 |
| D004958 | Estradiol | Estradiol binds to ESR1 protein | affects binding | 20686605 |
| C023482 | estradiol dipropionate | [estradiol dipropionate co-treated with Butyrates] results in decreased expression of ESR1 protein | affects cotreatment|decreases expression | 15930180 |
| C023482 | estradiol dipropionate | [estradiol dipropionate co-treated with trichostatin A] results in decreased expression of ESR1 protein | affects cotreatment|decreases expression | 15930180 |
| C015854 | estradiol valerate | estradiol valerate results in increased expression of ESR1 mRNA | increases expression | 15976194 |
| D004964 | Estriol | Estriol binds to ESR1 protein | affects binding | 11162928 |
| D004964 | Estriol | Estriol binds to ESR1 protein | affects binding | 11162928 |
| D004964 | Estriol | Estriol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15026083 |
| D004964 | Estriol | Estriol binds to ESR1 protein | affects binding | 11162928 11518614 |
| D004964 | Estriol | Estriol binds to ESR1 protein | affects binding | 15001543 |
| D004964 | Estriol | Estriol binds to ESR1 protein | affects binding | 11162928 |
| D004964 | Estriol | Estriol binds to ESR1 protein | affects binding | 11162928 |
| D004967 | Estrogens | ESR1 protein affects the reaction [Estrogens results in increased expression of VDR mRNA] | affects reaction|increases expression | 15664452 |
| D004967 | Estrogens | Estrogens deficiency results in decreased expression of ESR1 protein | decreases expression | 12021401 |
| D004967 | Estrogens | HDAC4 protein inhibits the reaction [Estrogens results in increased activity of ESR1 protein] | decreases reaction|increases activity | 16051668 |
| D004967 | Estrogens | Estrogens affects the activity of ESR1 protein | affects activity | 15893308 |
| D004967 | Estrogens | Estrogens results in increased expression of ESR1 protein | increases expression | 15994367 |
| D004966 | Estrogens, Conjugated (USP) | Estrogens, Conjugated (USP) affects the expression of ESR1 protein | affects expression | 16680078 15653758 |
| D004970 | Estrone | Estrone binds to ESR1 protein | affects binding | 11162928 |
| D004970 | Estrone | Estrone binds to ESR1 protein | affects binding | 11162928 |
| D004970 | Estrone | Estrone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12676605 |
| D004970 | Estrone | Estrone binds to ESR1 protein | affects binding | 11518614 11162928 |
| D004970 | Estrone | Estrone results in increased activity of ESR1 protein | increases activity | 11331656 |
| D004970 | Estrone | Estrone binds to ESR1 protein | affects binding | 15001543 |
| D004970 | Estrone | Estrone binds to ESR1 protein | affects binding | 11162928 |
| D004970 | Estrone | Estrone binds to ESR1 protein | affects binding | 11162928 11944962 |
| D004970 | Estrone | Estrone results in increased activity of ESR1 protein | increases activity | 11331656 |
| D004970 | Estrone | Estrone results in increased activity of ESR1 protein | increases activity | 11750080 |
| D004970 | Estrone | Estrone results in increased activity of ESR1 protein | increases activity | 17539551 |
| D004970 | Estrone | Estrone binds to ESR1 protein | affects binding | 11944962 |
| D004970 | Estrone | Estrone binds to ESR1 protein | affects binding | 19303142 |
| D000431 | Ethanol | Ethanol results in increased expression of ESR1 protein | increases expression | 15659783 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol binds to ESR1 protein | affects binding | 11162928 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol affects the expression of ESR1 mRNA | affects expression | 12505378 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased activity of ESR1 protein | increases activity | 12387416 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of ESR1 mRNA | increases expression | 17606305 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol binds to ESR1 protein | affects binding | 11162928 |
| D004997 | Ethinyl Estradiol | ESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of SCARB1 protein modified form] | decreases expression|increases reaction | 17673517 |
| D004997 | Ethinyl Estradiol | ESR1 protein promotes the reaction [Ethinyl Estradiol results in increased expression of SCARB2 protein modified form] | increases expression|increases reaction | 17673517 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol binds to ESR1 protein | affects binding | 11518614 11162928 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased activity of ESR1 protein | increases activity | 12387416 11331656 12623674 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| D004997 | Ethinyl Estradiol | ESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA] | decreases expression|increases reaction | 16606610 |
| D004997 | Ethinyl Estradiol | ESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of ABCG5 mRNA] | decreases expression|increases reaction | 16606610 |
| D004997 | Ethinyl Estradiol | ESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of ABCG8 mRNA] | decreases expression|increases reaction | 16606610 |
| D004997 | Ethinyl Estradiol | ESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of CYP7A1 mRNA] | decreases expression|increases reaction | 16606610 |
| D004997 | Ethinyl Estradiol | ESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of CYP8B1 mRNA] | decreases expression|increases reaction | 16606610 |
| D004997 | Ethinyl Estradiol | ESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA] | decreases expression|increases reaction | 16606610 |
| D004997 | Ethinyl Estradiol | ESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A1 mRNA] | decreases expression|increases reaction | 16606610 |
| D004997 | Ethinyl Estradiol | ESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of SLCO1B2 mRNA] | decreases expression|increases reaction | 16606610 |
| D004997 | Ethinyl Estradiol | ESR1 protein promotes the reaction [Ethinyl Estradiol results in increased expression of CYP7B1 mRNA] | increases expression|increases reaction | 16606610 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol affects the expression of ESR1 mRNA | affects expression | 17555576 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol binds to ESR1 protein | affects binding | 11162928 |
| D004997 | Ethinyl Estradiol | [Ethinyl Estradiol co-treated with ESR1 protein] inhibits the reaction [IL1B protein results in increased expression of BCL3 mRNA] | affects cotreatment|decreases reaction|increases expression | 12072388 |
| D004997 | Ethinyl Estradiol | [Ethinyl Estradiol co-treated with ESR1 protein] inhibits the reaction [IL1B protein results in increased expression of CISH mRNA] | affects cotreatment|decreases reaction|increases expression | 12072388 |
| D004997 | Ethinyl Estradiol | [Ethinyl Estradiol co-treated with ESR1 protein] inhibits the reaction [IL1B protein results in increased expression of CXCL5 mRNA] | affects cotreatment|decreases reaction|increases expression | 12072388 |
| D004997 | Ethinyl Estradiol | [Ethinyl Estradiol co-treated with ESR1 protein] inhibits the reaction [IL1B protein results in increased expression of NR0B2 mRNA] | affects cotreatment|decreases reaction|increases expression | 12072388 |
| D004997 | Ethinyl Estradiol | [Ethinyl Estradiol co-treated with ESR1 protein] inhibits the reaction [IL1B protein results in increased expression of PLK3 mRNA] | affects cotreatment|decreases reaction|increases expression | 12072388 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in decreased expression of ESR1 mRNA | decreases expression | 17942748 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of ESR1 mRNA | increases expression | 17509364 16606610 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of ESR1 protein | increases expression | 17509364 |
| D004997 | Ethinyl Estradiol | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 17942748 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol binds to ESR1 protein | affects binding | 11944962 11162928 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased activity of ESR1 protein | increases activity | 11331656 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of ESR1 mRNA | increases expression | 17089724 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of ESR1 mRNA | increases expression | 18000313 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of ESR1 mRNA | increases expression | 15820104 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol affects the expression of ESR1 mRNA | affects expression | 17222921 |
| D004997 | Ethinyl Estradiol | Benzo(a)pyrene affects the reaction [Ethinyl Estradiol results in decreased expression of ESR1 protein] | affects reaction|decreases expression | 17583486 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol affects the expression of ESR1 mRNA | affects expression | 20170705 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in decreased expression of ESR1 mRNA | decreases expression | 17161848 16551644 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in decreased expression of ESR1 protein | decreases expression | 16837883 17583486 11218048 14709816 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased activity of ESR1 protein | increases activity | 11750080 12504345 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of ESR1 protein | increases expression | 17157476 11731036 11748029 |
| D004997 | Ethinyl Estradiol | Tretinoin inhibits the reaction [Ethinyl Estradiol results in decreased expression of ESR1 mRNA] | decreases expression|decreases reaction | 17161848 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol affects the expression of ESR1 | affects expression | 17539551 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol binds to ESR1 protein | affects binding | 11944962 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in decreased expression of ESR1 mRNA | decreases expression | 17875331 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of ESR1 mRNA | increases expression | 16484284 |
| D004997 | Ethinyl Estradiol | tributyltin inhibits the reaction [Ethinyl Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 16484284 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol binds to ESR1 protein | affects binding | 19303142 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol analog binds to ESR1 protein | affects binding | 15041288 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol binds to ESR1 protein | affects binding | 15041288 |
| D008656 | Mestranol | Mestranol results in increased activity of ESR1 protein | increases activity | 12623674 |
| D008656 | Mestranol | Mestranol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| D019304 | Ethinyl Estradiol-Norgestrel Combination | Ethinyl Estradiol-Norgestrel Combination results in increased expression of ESR1 protein | increases expression | 11056131 |
| C100038 | ethion | ethion results in increased activity of ESR1 protein | increases activity | 15064155 |
| C041062 | ethyl bromophos | ethyl bromophos results in increased activity of ESR1 protein | increases activity | 15064155 |
| C451418 | ethyl cinnamate | ethyl cinnamate binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16079615 |
| C056516 | exemestane | 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [exemestane binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 18677558 |
| C056516 | exemestane | exemestane binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 18677558 |
| C056516 | exemestane | fulvestrant inhibits the reaction [exemestane binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 18677558 |
| D015025 | Zearalenone | Zearalenone binds to ESR1 protein | affects binding | 11162928 |
| D015025 | Zearalenone | Zearalenone binds to ESR1 protein | affects binding | 11162928 |
| D015025 | Zearalenone | fulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein] | affects binding|decreases reaction|increases activity | 12650720 |
| D015025 | Zearalenone | Zearalenone binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 15084758 |
| D015025 | Zearalenone | Zearalenone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9751507 15084758 |
| D015025 | Zearalenone | Zearalenone binds to ESR1 protein | affects binding | 11162928 15169976 |
| D015025 | Zearalenone | [Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein | affects binding|increases activity | 12650720 |
| D015025 | Zearalenone | Zearalenone promotes the reaction [NCOA2 protein binds to ESR1 protein] | affects binding|increases reaction | 15084758 |
| D015025 | Zearalenone | Zearalenone results in increased activity of ESR1 protein | increases activity | 11331656 |
| D015025 | Zearalenone | Zearalenone binds to ESR1 protein | affects binding | 15001543 |
| D015025 | Zearalenone | Zearalenone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 20209442 |
| D015025 | Zearalenone | Zearalenone binds to ESR1 protein | affects binding | 11162928 |
| D015025 | Zearalenone | Zearalenone binds to ESR1 protein | affects binding | 11162928 11944962 |
| D015025 | Zearalenone | Zearalenone results in increased activity of ESR1 protein | increases activity | 11331656 |
| D015025 | Zearalenone | Zearalenone results in increased expression of ESR1 mRNA | increases expression | 18538753 |
| D015025 | Zearalenone | Zearalenone results in increased activity of ESR1 protein | increases activity | 11750080 |
| D015025 | Zearalenone | Zearalenone binds to ESR1 protein | affects binding | 11944962 |
| C015881 | farrerol | farrerol results in increased phosphorylation of ESR1 protein | increases phosphorylation | 17323972 |
| C033789 | fenarimol | fenarimol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16626760 10789375 |
| C033789 | fenarimol | fenarimol binds to ESR1 protein | affects binding | 15253041 |
| C033789 | fenarimol | fenarimol results in decreased expression of ESR1 mRNA | decreases expression | 15261991 |
| C033789 | fenarimol | fenarimol results in increased activity of ESR1 protein | increases activity | 15064155 |
| C504383 | fenbuconazole | fenbuconazole binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16626760 |
| C017690 | fenvalerate | fenvalerate binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16626760 |
| C017690 | fenvalerate | fenvalerate results in increased activity of ESR1 protein | increases activity | 15064155 |
| C017690 | fenvalerate | fenvalerate binds to ESR1 protein | affects binding | 12396874 |
| C017875 | fisetin | fisetin results in increased activity of ESR1 protein | increases activity | 18980245 |
| D005419 | Flavonoids | Flavonoids analog binds to ESR1 protein | affects binding | 16892383 |
| C050585 | fluazifop-butyl | fluazifop-butyl results in increased activity of ESR1 protein | increases activity | 15064155 |
| C027975 | flucythrinate | flucythrinate results in increased activity of ESR1 protein | increases activity | 15064155 |
| C007738 | fluoranthene | fluoranthene promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 12441364 |
| C007738 | fluoranthene | fulvestrant inhibits the reaction [fluoranthene promotes the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity|increases reaction | 12441364 |
| D005485 | Flutamide | Flutamide results in decreased expression of ESR1 mRNA | decreases expression | 17222921 |
| D005485 | Flutamide | Flutamide results in increased expression of ESR1 mRNA | increases expression | 16003321 |
| D005485 | Flutamide | Flutamide results in increased expression of ESR1 protein | increases expression | 11748029 16003321 |
| C475882 | flutolanil | flutolanil binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 17904202 |
| C475882 | flutolanil | flutolanil results in decreased expression of ESR1 protein | decreases expression | 17904202 |
| C007768 | formononetin | formononetin results in increased activity of ESR1 protein | increases activity | 18980245 |
| C007768 | formononetin | formononetin binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9751507 16076101 |
| C007768 | formononetin | formononetin binds to ESR1 protein | affects binding | 16773531 |
| C070081 | fulvestrant | AG 1879 inhibits the reaction [fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]] | affects binding|decreases reaction|increases reaction | 19815064 |
| C070081 | fulvestrant | Curcumin inhibits the reaction [fulvestrant results in increased degradation of ESR1 protein] | decreases reaction|increases degradation | 15899841 |
| C070081 | fulvestrant | [Estradiol co-treated with fulvestrant co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA | affects cotreatment|increases expression | 19351862 |
| C070081 | fulvestrant | fulvestrant affects the activity of ESR1 protein | affects activity | 15950373 19339991 18635651 |
| C070081 | fulvestrant | fulvestrant affects the expression of ESR1 mRNA | affects expression | 20543978 |
| C070081 | fulvestrant | fulvestrant affects the folding of and affects the activity of ESR1 protein | affects activity|affects folding | 17299137 |
| C070081 | fulvestrant | fulvestrant binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 20211987 |
| C070081 | fulvestrant | [fulvestrant binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA | affects binding|increases activity|increases expression | 11174852 |
| C070081 | fulvestrant | fulvestrant binds to ESR1 protein | affects binding | 15842231 11518614 17203231 16037132 |
| C070081 | fulvestrant | [fulvestrant co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA | affects cotreatment|increases expression | 19351862 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17872378 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 16489053 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [[6-(1,1-dimethylallyl)naringenin binds to ESR1 protein] which results in increased activity of ALPL protein] | affects binding|decreases reaction|increases activity | 12650720 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein] | affects binding|decreases reaction|increases activity | 12650720 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [Androstane-3,17-diol analog binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 17003281 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [Androstane-3,17-diol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 17003281 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [benz(a)anthracene promotes the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity|increases reaction | 12441364 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [Benzo(a)pyrene promotes the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity|increases reaction | 12441364 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [[Coumestrol binds to ESR1 protein] which results in increased activity of ALPL protein] | affects binding|decreases reaction|increases activity | 12650720 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [[daidzein binds to ESR1 protein] which results in increased activity of ALPL protein] | affects binding|decreases reaction|increases activity | 12650720 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [Diethylstilbestrol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 18028983 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [ESR1 protein binds to CDKN1A promoter] | affects binding|decreases reaction | 20696891 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [ESR1 protein binds to STUB1 protein] | affects binding|decreases reaction | 16037132 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [[Estradiol binds to ESR1 protein] which results in increased activity of ALPL protein] | affects binding|decreases reaction|increases activity | 12650720 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased expression of NOS3 mRNA] | affects cotreatment|decreases reaction|increases expression | 14742696 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA] | decreases expression|decreases reaction | 15130599 19620290 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 20061804 17872378 12441364 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 16076840 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [exemestane binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 18677558 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [fluoranthene promotes the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity|increases reaction | 12441364 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [[Genistein binds to ESR1 protein] which results in increased activity of ALPL protein] | affects binding|decreases reaction|increases activity | 12650720 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [Methylcholanthrene results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 16489053 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein] | affects binding|decreases reaction|increases activity | 12650720 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [prochloraz results in decreased expression of ESR1 mRNA] | decreases expression|decreases reaction | 15130599 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]] | affects binding|decreases reaction|increases reaction | 17513867 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]] | affects binding|decreases reaction|increases reaction | 19460354 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]] | affects binding|decreases reaction|increases reaction | 19460354 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein] | affects binding|decreases reaction|increases activity | 12650720 |
| C070081 | fulvestrant | fulvestrant promotes the reaction [ESR1 protein binds to ESR1 protein] | affects binding|increases reaction | 20061804 |
| C070081 | fulvestrant | fulvestrant promotes the reaction [ESR1 protein binds to ESR2 protein] | affects binding|increases reaction | 20061804 |
| C070081 | fulvestrant | fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein] | affects binding|increases reaction | 19815064 |
| C070081 | fulvestrant | fulvestrant results in decreased activity of and results in decreased expression of ESR1 protein | decreases activity|decreases expression | 20208560 |
| C070081 | fulvestrant | fulvestrant results in decreased activity of ESR1 protein | decreases activity | 16010691 |
| C070081 | fulvestrant | fulvestrant results in decreased expression of ESR1 protein | decreases expression | 11867264 19815064 19435893 19264808 15950373 16202921 |
| C070081 | fulvestrant | fulvestrant results in increased degradation of and results in decreased expression of and results in decreased activity of ESR1 protein | decreases activity|decreases expression|increases degradation | 15475434 |
| C070081 | fulvestrant | fulvestrant results in increased degradation of ESR1 mRNA | increases degradation | 20215421 |
| C070081 | fulvestrant | fulvestrant results in increased degradation of ESR1 protein | increases degradation | 20179196 15899841 19620290 20208560 20061804 19477949 |
| C070081 | fulvestrant | KRT18 protein promotes the reaction [fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity|increases reaction | 20061804 |
| C070081 | fulvestrant | KRT18 protein promotes the reaction [fulvestrant results in increased degradation of ESR1 protein] | increases degradation|increases reaction | 20061804 |
| C070081 | fulvestrant | KRT8 protein promotes the reaction [fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity|increases reaction | 20061804 |
| C070081 | fulvestrant | KRT8 protein promotes the reaction [fulvestrant results in increased degradation of ESR1 protein] | increases degradation|increases reaction | 20061804 |
| C070081 | fulvestrant | tyrphostin AG 1024 inhibits the reaction [fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]] | affects binding|decreases reaction|increases reaction | 19815064 |
| C070081 | fulvestrant | fulvestrant binds to ESR1 protein | affects binding | 15001543 |
| C070081 | fulvestrant | [bisphenol A co-treated with fulvestrant] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 12927369 |
| C070081 | fulvestrant | fulvestrant binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 18417718 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]] | decreases reaction|increases expression|increases reaction | 17974624 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 20209442 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 16280380 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [octylphenol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 18417718 |
| C070081 | fulvestrant | fulvestrant promotes the reaction [bisphenol A results in decreased expression of ESR1 protein] | decreases expression|increases reaction | 12927369 |
| C070081 | fulvestrant | fulvestrant promotes the reaction [Estradiol results in increased expression of ESR1 protein] | increases expression|increases reaction | 19340542 |
| C070081 | fulvestrant | fulvestrant results in decreased expression of ESR1 protein | decreases expression | 12927369 |
| C070081 | fulvestrant | 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [fulvestrant binds to and results in decreased activity of ESR1 protein] | affects binding|decreases activity|decreases reaction | 20419096 |
| C070081 | fulvestrant | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [fulvestrant results in increased degradation of ESR1 protein] | decreases reaction|increases degradation | 20419096 |
| C070081 | fulvestrant | fulvestrant binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 20419096 19570671 |
| C070081 | fulvestrant | fulvestrant results in increased degradation of ESR1 protein | increases degradation | 20419096 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 17291011 |
| C070081 | fulvestrant | fulvestrant binds to ESR1 protein | affects binding | 19303142 |
| C070081 | fulvestrant | fulvestrant results in decreased activity of ESR1 protein | decreases activity | 15458977 |
| C070081 | fulvestrant | fulvestrant results in increased expression of ESR1 | increases expression | 19528477 |
| C037032 | galangin | galangin results in increased phosphorylation of ESR1 protein | increases phosphorylation | 17323972 |
| C419708 | gefitinib | gefitinib results in decreased phosphorylation of ESR1 protein | decreases phosphorylation | 16261397 |
| C001277 | geldanamycin | geldanamycin inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 11448926 |
| C001277 | geldanamycin | geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein] | affects binding|increases reaction | 16037132 |
| C001277 | geldanamycin | geldanamycin results in decreased expression of ESR1 protein | decreases expression | 11448926 |
| C001277 | geldanamycin | geldanamycin results in decreased stability of ESR1 protein | decreases stability | 11448926 |
| C001277 | geldanamycin | geldanamycin results in increased degradation of ESR1 protein | increases degradation | 16037132 |
| C001277 | geldanamycin | STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein] | increases degradation|increases reaction | 16037132 |
| D019833 | Genistein | Genistein binds to ESR1 protein | affects binding | 11162928 |
| D019833 | Genistein | Genistein results in increased activity of ESR1 protein | increases activity | 18980245 |
| D019833 | Genistein | Genistein binds to ESR1 protein | affects binding | 11162928 |
| D019833 | Genistein | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [Genistein binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 11861976 |
| D019833 | Genistein | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Genistein binds to and results in increased activity of ESR1 protein] | affects binding|increases activity|increases reaction | 11861976 |
| D019833 | Genistein | beta Carotene inhibits the reaction [Genistein results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17051425 |
| D019833 | Genistein | ESR1 protein affects the susceptibility to Genistein | affects response to substance | 17275032 |
| D019833 | Genistein | [Estradiol co-treated with Genistein co-treated with o,p'-DDT] affects the expression of ESR1 mRNA | affects cotreatment|affects expression | 11922773 |
| D019833 | Genistein | fulvestrant inhibits the reaction [[Genistein binds to ESR1 protein] which results in increased activity of ALPL protein] | affects binding|decreases reaction|increases activity | 12650720 |
| D019833 | Genistein | Genistein binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16541309 9751507 15937998 11502892 15876408 15026083 10397250 11861976 16076101 |
| D019833 | Genistein | Genistein binds to ESR1 protein | affects binding | 11162928 14579009 11368622 16566672 15521089 11518614 17400923 16506809 |
| D019833 | Genistein | [Genistein binds to ESR1 protein] which binds to NCOA2 protein | affects binding | 15123288 |
| D019833 | Genistein | [Genistein binds to ESR1 protein] which results in increased activity of ALPL protein | affects binding|increases activity | 12650720 |
| D019833 | Genistein | [Genistein co-treated with ESR1 protein] results in decreased expression of EGFR mRNA | affects cotreatment|decreases expression | 19347870 |
| D019833 | Genistein | [Genistein co-treated with ESR1 protein] results in decreased expression of EGFR protein | affects cotreatment|decreases expression | 19347870 |
| D019833 | Genistein | [Genistein co-treated with ESR1 protein] results in increased expression of BGLAP mRNA | affects cotreatment|increases expression | 19347870 |
| D019833 | Genistein | [Genistein co-treated with ESR1] results in increased expression of BSP mRNA | affects cotreatment|increases expression | 19347870 |
| D019833 | Genistein | Genistein inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 11368622 14579009 16566672 10964929 |
| D019833 | Genistein | Genistein inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 16434996 |
| D019833 | Genistein | Genistein promotes the reaction [ESR1 protein binds to ESR1 protein] | affects binding|increases reaction | 15713566 |
| D019833 | Genistein | Genistein promotes the reaction [ESR1 protein binds to NCOA1 protein] | affects binding|increases reaction | 10964929 |
| D019833 | Genistein | Genistein promotes the reaction [ESR1 protein binds to NCOA2 protein] | affects binding|increases reaction | 10964929 |
| D019833 | Genistein | Genistein promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 16118406 |
| D019833 | Genistein | Genistein promotes the reaction [NCOA2 protein binds to ESR1 protein] | affects binding|increases reaction | 15084758 |
| D019833 | Genistein | Genistein results in decreased expression of ESR1 mRNA | decreases expression | 11502892 16033089 15968319 |
| D019833 | Genistein | Genistein results in decreased expression of ESR1 protein | decreases expression | 16033089 11502892 16541309 |
| D019833 | Genistein | Genistein results in increased activity of ESR1 protein | increases activity | 17132221 14975756 11485867 19161236 16118406 |
| D019833 | Genistein | Genistein results in increased expression of ESR1 mRNA | increases expression | 15968319 11922773 |
| D019833 | Genistein | Methoxychlor metabolite inhibits the reaction [Genistein binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 11861976 |
| D019833 | Genistein | Methoxychlor metabolite promotes the reaction [Genistein binds to and results in increased activity of ESR1 protein] | affects binding|increases activity|increases reaction | 11861976 |
| D019833 | Genistein | Genistein binds to ESR1 protein | affects binding | 15001543 |
| D019833 | Genistein | ESR1 protein promotes the reaction [Genistein results in increased phosphorylation of and results in increased activity of IGF1R protein] | increases activity|increases phosphorylation|increases reaction | 10965916 |
| D019833 | Genistein | Genistein binds to ESR1 protein | affects binding | 11162928 |
| D019833 | Genistein | Genistein results in decreased expression of ESR1 mRNA | decreases expression | 16985261 16857750 11880592 14871586 |
| D019833 | Genistein | Genistein results in increased activity of ESR1 protein | increases activity | 19495926 |
| D019833 | Genistein | Genistein results in increased expression of ESR1 mRNA | increases expression | 18359623 |
| D019833 | Genistein | Genistein binds to ESR1 protein | affects binding | 11944962 11162928 |
| D019833 | Genistein | Genistein affects the expression of ESR1 protein | affects expression | 11731036 |
| D019833 | Genistein | [Genistein co-treated with Methoxychlor] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 16443925 |
| D019833 | Genistein | Genistein inhibits the reaction [Estradiol affects the expression of ESR1 mRNA] | affects expression|decreases reaction | 17049845 |
| D019833 | Genistein | Genistein results in decreased expression of ESR1 | decreases expression | 12929590 |
| D019833 | Genistein | Genistein results in decreased expression of ESR1 protein | decreases expression | 15778002 |
| D019833 | Genistein | Genistein results in increased activity of ESR1 protein | increases activity | 11750080 |
| D019833 | Genistein | Genistein results in increased expression of ESR1 mRNA | increases expression | 17341692 16443925 |
| D019833 | Genistein | Genistein results in increased phosphorylation of ESR1 protein | increases phosphorylation | 17323972 |
| D019833 | Genistein | [Methoxychlor co-treated with Genistein] results in increased expression of ESR1 protein | affects cotreatment|increases expression | 11896288 |
| D019833 | Genistein | Genistein binds to ESR1 protein | affects binding | 11944962 |
| D019833 | Genistein | Genistein results in increased activity of ESR1 protein | increases activity | 11403899 |
| D005947 | Glucose | Glucose results in decreased expression of ESR1 mRNA | decreases expression | 16621514 |
| D005947 | Glucose | Glucose results in increased expression of ESR1 mRNA | increases expression | 16621514 |
| C017343 | glyceollin | glyceollin binds to ESR1 protein | affects binding | 19797619 |
| C017343 | glyceollin | glyceollin inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 19797619 |
| C086566 | glycitein | glycitein binds to ESR1 protein | affects binding | 14579009 |
| C086566 | glycitein | glycitein inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D007987 | Gonadotropin-Releasing Hormone | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gonadotropin-Releasing Hormone results in decreased expression of ESR1 protein] | decreases expression|decreases reaction | 16055746 |
| D007987 | Gonadotropin-Releasing Hormone | Gonadotropin-Releasing Hormone results in increased ubiquitination of and results in increased degradation of and results in decreased expression of ESR1 protein | decreases expression|increases degradation|increases ubiquitination | 16055746 |
| D017273 | Goserelin | Goserelin results in decreased expression of ESR1 protein | decreases expression | 16973256 |
| C401858 | GW 7604 | GW 7604 analog binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 17033922 |
| C401858 | GW 7604 | GW 7604 analog binds to ESR1 protein | affects binding | 17033922 |
| C401858 | GW 7604 | GW 7604 analog inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17033922 |
| C401858 | GW 7604 | GW 7604 binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 17033922 |
| C401858 | GW 7604 | GW 7604 binds to ESR1 protein | affects binding | 17033922 |
| C401858 | GW 7604 | GW 7604 inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17033922 |
| C401858 | GW 7604 | GW 7604 results in decreased expression of ESR1 protein | decreases expression | 17033922 |
| D055768 | Halogenated Diphenyl Ethers | Halogenated Diphenyl Ethers binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 11335189 |
| D006533 | Heptachlor | Heptachlor binds to ESR1 protein | affects binding | 12505301 |
| D006533 | Heptachlor | Heptachlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 12505301 |
| D006533 | Heptachlor | Heptachlor results in increased activity of ESR1 protein | increases activity | 18980245 |
| D006534 | Heptachlor Epoxide | Heptachlor Epoxide binds to ESR1 protein | affects binding | 12505301 |
| D006534 | Heptachlor Epoxide | Heptachlor Epoxide inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 12505301 |
| D006534 | Heptachlor Epoxide | Heptachlor Epoxide results in increased activity of ESR1 protein | increases activity | 15064155 |
| D006830 | Hydralazine | Hydralazine results in decreased methylation of ESR1 promoter | decreases methylation | 15862127 |
| D006830 | Hydralazine | Hydralazine results in increased expression of ESR1 mRNA | increases expression | 15862127 |
| C029424 | hydrazine | hydrazine results in decreased expression of ESR1 mRNA | decreases expression | 15282401 |
| D006854 | Hydrocortisone | Hydrocortisone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12676605 |
| D016627 | Oxidopamine | Oxidopamine results in increased expression of ESR1 mRNA | increases expression | 12486162 |
| C475919 | hydroxytamoxifen | hydroxytamoxifen binds to ESR1 protein | affects binding | 11518614 |
| C475919 | hydroxytamoxifen | hydroxytamoxifen inhibits the reaction [bisphenol A results in increased activity of ESR1 protein] | decreases reaction|increases activity | 14709801 |
| C475919 | hydroxytamoxifen | hydroxytamoxifen inhibits the reaction [nonylphenol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 14709801 |
| C051781 | ICI 164384 | ICI 164384 binds to ESR1 protein | affects binding | 11162928 |
| C051781 | ICI 164384 | ICI 164384 binds to ESR1 protein | affects binding | 11162928 |
| C051781 | ICI 164384 | ICI 164384 binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 11174852 |
| C051781 | ICI 164384 | [ICI 164384 binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA | affects binding|increases activity|increases expression | 11174852 |
| C051781 | ICI 164384 | ICI 164384 binds to ESR1 protein | affects binding | 11162928 |
| C051781 | ICI 164384 | ICI 164384 binds to ESR1 protein | affects binding | 15001543 |
| C051781 | ICI 164384 | ICI 164384 binds to ESR1 protein | affects binding | 11162928 |
| C051781 | ICI 164384 | ICI 164384 binds to ESR1 protein | affects binding | 11162928 |
| C051781 | ICI 164384 | ICI 164384 inhibits the reaction [Chlordecone results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 8800639 |
| C051781 | ICI 164384 | ICI 164384 inhibits the reaction [Lindane results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 8800639 |
| C051781 | ICI 164384 | ICI 164384 inhibits the reaction [nonylphenol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 8800639 |
| D007189 | Indans | Indans analog results in decreased activity of ESR1 protein | decreases activity | 15737489 |
| D007189 | Indans | Indans analog results in increased activity of ESR1 protein | increases activity | 15737489 |
| C047437 | indenestrol | indenestrol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15465114 |
| C016517 | indole-3-carbinol | BRCA1 protein promotes the reaction [indole-3-carbinol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity|increases reaction | 11110848 |
| C016517 | indole-3-carbinol | indole-3-carbinol analog results in decreased expression of ESR1 protein | decreases expression | 20570586 |
| C016517 | indole-3-carbinol | indole-3-carbinol inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 16434996 11110848 |
| D007211 | Indoles | Indoles analog binds to and affects the activity of ESR1 protein | affects activity|affects binding | 15911274 |
| C018986 | ipriflavone | ipriflavone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9751507 |
| C035019 | isofenphos | isofenphos results in increased activity of ESR1 protein | increases activity | 15064155 |
| D007529 | Isoflavones | Isoflavones results in increased activity of ESR1 protein | increases activity | 11485867 |
| C038267 | isopropyl 4,4'-dibromobenzilate | isopropyl 4,4'-dibromobenzilate results in increased activity of ESR1 protein | increases activity | 15064155 |
| C023889 | isoprothiolane | isoprothiolane binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 17904202 |
| C023889 | isoprothiolane | isoprothiolane results in decreased expression of ESR1 protein | decreases expression | 17904202 |
| C512910 | isoxanthohumol | isoxanthohumol results in increased activity of ESR1 protein | increases activity | 12623674 |
| C113642 | JK 1624F2-1 | JK 1624F2-1 results in increased expression of ESR1 mRNA | increases expression | 16406510 |
| C006552 | kaempferol | kaempferol results in increased activity of ESR1 protein | increases activity | 18980245 |
| C006552 | kaempferol | Estradiol affects the reaction [kaempferol results in increased activity of ESR1 protein] | affects reaction|increases activity | 16118406 |
| C006552 | kaempferol | kaempferol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9751507 15182386 |
| C006552 | kaempferol | kaempferol binds to ESR1 protein | affects binding | 14706564 14579009 |
| C006552 | kaempferol | kaempferol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| C006552 | kaempferol | kaempferol results in increased activity of ESR1 protein | increases activity | 16118406 |
| C006552 | kaempferol | kaempferol results in increased expression of ESR1 mRNA | increases expression | 15182386 |
| D007654 | Ketoconazole | Ketoconazole results in decreased expression of ESR1 mRNA | decreases expression | 18800561 |
| C490728 | lapatinib | [lapatinib co-treated with 4-hydroxytamoxifen] results in decreased activity of ESR1 protein | affects cotreatment|decreases activity | 15665275 |
| C490728 | lapatinib | lapatinib results in decreased activity of ESR1 protein | decreases activity | 15665275 |
| C038753 | leptomycin B | leptomycin B inhibits the reaction [Estradiol results in increased degradation of ESR1 protein] | decreases reaction|increases degradation | 15899841 |
| D010773 | Leptophos | Leptophos results in increased activity of ESR1 protein | increases activity | 15064155 |
| C067431 | letrozole | letrozole results in decreased expression of ESR1 mRNA | decreases expression | 20044124 |
| D001556 | Lindane | Lindane binds to ESR1 protein | affects binding | 15253041 14579009 |
| D001556 | Lindane | [Lindane co-treated with DDT] results in increased expression of ESR1 | affects cotreatment|increases expression | 16329587 |
| D001556 | Lindane | Lindane inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| D001556 | Lindane | Lindane binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 20209442 |
| D001556 | Lindane | 4-hydroxytamoxifen inhibits the reaction [Lindane results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 8800639 |
| D001556 | Lindane | ICI 164384 inhibits the reaction [Lindane results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 8800639 |
| D001556 | Lindane | Lindane binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9460653 |
| D001556 | Lindane | Lindane results in increased expression of ESR1 mRNA | increases expression | 8800639 |
| D008043 | Linseed Oil | Linseed Oil results in decreased expression of ESR1 protein | decreases expression | 19904759 |
| D008043 | Linseed Oil | Linseed Oil results in decreased expression of ESR1 protein | decreases expression | 21138602 |
| D008043 | Linseed Oil | Linseed Oil results in decreased phosphorylation of ESR1 protein | decreases phosphorylation | 21138602 |
| D008043 | Linseed Oil | Linseed Oil results in increased expression of ESR1 mRNA | increases expression | 21138602 |
| D008043 | Linseed Oil | Tamoxifen promotes the reaction [Linseed Oil results in decreased expression of ESR1 protein] | decreases expression|increases reaction | 21138602 |
| D008055 | Lipids | ESR1 protein promotes the reaction [Tamoxifen results in increased abundance of Lipids] | increases abundance|increases reaction | 20079722 |
| D008070 | Lipopolysaccharides | ESR1 protein affects the reaction [Lipopolysaccharides affects the expression of GUCY1A3 mRNA] | affects expression|affects reaction | 17158209 |
| D008070 | Lipopolysaccharides | ESR1 protein affects the reaction [Lipopolysaccharides affects the expression of GUCY1A3 protein] | affects expression|affects reaction | 17158209 |
| D008070 | Lipopolysaccharides | ESR1 protein affects the reaction [Lipopolysaccharides affects the expression of GUCY1B3 mRNA] | affects expression|affects reaction | 17158209 |
| D008070 | Lipopolysaccharides | ESR1 protein affects the reaction [Lipopolysaccharides affects the expression of GUCY1B3 protein] | affects expression|affects reaction | 17158209 |
| D008070 | Lipopolysaccharides | ESR1 protein affects the reaction [Lipopolysaccharides affects the expression of NOS3 mRNA] | affects expression|affects reaction | 17158209 |
| D008070 | Lipopolysaccharides | ESR1 protein affects the reaction [Lipopolysaccharides affects the expression of NOS3 protein] | affects expression|affects reaction | 17158209 |
| D008070 | Lipopolysaccharides | ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Acetylcholine] | affects cotreatment|affects response to substance | 17158209 |
| D008070 | Lipopolysaccharides | ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Nitroprusside] | affects cotreatment|affects response to substance | 17158209 |
| D008070 | Lipopolysaccharides | ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine] | affects cotreatment|affects response to substance | 17158209 |
| D008070 | Lipopolysaccharides | ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Acetylcholine] | affects cotreatment|affects response to substance | 17158209 |
| D008070 | Lipopolysaccharides | ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Nitroprusside] | affects cotreatment|affects response to substance | 17158209 |
| D008070 | Lipopolysaccharides | Lipopolysaccharides results in increased expression of ESR1 mRNA | increases expression | 12057914 |
| D018021 | Lithium Chloride | Lithium Chloride inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 16076840 |
| D018021 | Lithium Chloride | Lithium Chloride inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein] | decreases reaction|increases phosphorylation | 16076840 |
| D018021 | Lithium Chloride | Lithium Chloride results in decreased phosphorylation of and results in decreased stability of and results in decreased expression of ESR1 protein | decreases expression|decreases phosphorylation|decreases stability | 16076840 |
| D017336 | Loratadine | Loratadine results in increased expression of ESR1 mRNA | increases expression | 16407038 |
| D047311 | Luteolin | Luteolin results in increased activity of ESR1 protein | increases activity | 18980245 |
| D047311 | Luteolin | Luteolin binds to ESR1 protein | affects binding | 14579009 |
| D047311 | Luteolin | Luteolin inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| C025430 | LY 117018 | LY 117018 binds to ESR1 protein | affects binding | 10397250 |
| C504960 | LY2066948 | LY2066948 binds to ESR1 protein | affects binding | 16002528 |
| C115121 | LY 353381 | LY 353381 analog results in decreased activity of ESR1 protein | decreases activity | 17654759 |
| C115121 | LY 353381 | LY 353381 binds to ESR1 protein | affects binding | 16780356 11731420 |
| C115121 | LY 353381 | [LY 353381 co-treated with CCND1 protein] affects the folding of ESR1 protein | affects cotreatment|affects folding | 19477949 |
| C115121 | LY 353381 | [LY 353381 co-treated with CCND1 protein] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 19477949 |
| C115121 | LY 353381 | [LY 353381 co-treated with CCND1 protein] results in increased stability of [ESR1 protein binds to NCOA1 protein] | affects binding|affects cotreatment|increases stability | 19477949 |
| C115121 | LY 353381 | LY 353381 results in decreased activity of ESR1 protein | decreases activity | 17654759 |
| C115121 | LY 353381 | LY 353381 results in increased stability of ESR1 protein | increases stability | 19477949 |
| C115121 | LY 353381 | ESR1 protein promotes the reaction [LY 353381 results in increased phosphorylation of and results in increased activity of IGF1R protein] | increases activity|increases phosphorylation|increases reaction | 10965916 |
| C015329 | lycopene | lycopene inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17051425 |
| C015329 | lycopene | lycopene results in increased expression of ESR1 mRNA | increases expression | 16886892 |
| C005095 | malachite green | ESR1 protein inhibits the reaction [[malachite green co-treated with GH1 protein] results in increased activity of GHR1 protein] | affects cotreatment|decreases reaction|increases activity | 20467862 |
| C005095 | malachite green | ESR1 protein inhibits the reaction [[malachite green co-treated with GH1 protein] results in increased activity of GHR2 protein] | affects cotreatment|decreases reaction|increases activity | 20467862 |
| C005095 | malachite green | malachite green inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 18980245 |
| D017258 | Medroxyprogesterone Acetate | ESR1 protein promotes the reaction [Medroxyprogesterone Acetate results in increased expression of EPHX1 protein] | increases expression|increases reaction | 20383792 |
| D008550 | Melatonin | Melatonin inhibits the reaction [Cadmium results in increased activity of ESR1 protein] | decreases reaction|increases activity | 16635015 |
| D008550 | Melatonin | Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 15813899 |
| D008550 | Melatonin | Pertussis Toxin inhibits the reaction [Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity | 15813899 |
| D008550 | Melatonin | Melatonin results in decreased expression of ESR1 mRNA | decreases expression | 16030176 |
| D008550 | Melatonin | Melatonin promotes the reaction [alitretinoin results in decreased expression of ESR1 mRNA] | decreases expression|increases reaction | 16051031 |
| D008550 | Melatonin | Melatonin results in decreased expression of ESR1 mRNA | decreases expression | 16051031 |
| D008552 | Melengestrol Acetate | Melengestrol Acetate results in increased activity of ESR1 protein | increases activity | 11331656 |
| D000432 | Methanol | Methanol results in increased expression of ESR1 protein | increases expression | 15659783 |
| D008714 | Methiocarb | Methiocarb results in increased activity of ESR1 protein | increases activity | 15064155 |
| D008724 | Methomyl | Methomyl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 9126867 |
| C013598 | methoxyacetic acid | methoxyacetic acid promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 18486176 15103026 |
| C013598 | methoxyacetic acid | methoxyacetic acid promotes the reaction [Tamoxifen results in increased activity of ESR1 protein] | increases activity|increases reaction | 15103026 |
| D008731 | Methoxychlor | [Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein] | affects activity|increases activity|increases reaction | 14975756 |
| D008731 | Methoxychlor | Methoxychlor analog binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 10999957 |
| D008731 | Methoxychlor | Methoxychlor binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 10774817 16626760 |
| D008731 | Methoxychlor | Methoxychlor binds to ESR1 protein | affects binding | 15253041 9751507 14579009 |
| D008731 | Methoxychlor | Methoxychlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 9751507 |
| D008731 | Methoxychlor | Methoxychlor inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to HOXA10 gene]] | affects binding|decreases reaction|increases reaction | 15890768 |
| D008731 | Methoxychlor | Methoxychlor metabolite binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 10579340 |
| D008731 | Methoxychlor | Methoxychlor metabolite inhibits the reaction [Genistein binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 11861976 |
| D008731 | Methoxychlor | Methoxychlor metabolite promotes the reaction [Genistein binds to and results in increased activity of ESR1 protein] | affects binding|increases activity|increases reaction | 11861976 |
| D008731 | Methoxychlor | Methoxychlor metabolite results in increased activity of ESR1 protein | increases activity | 12623674 |
| D008731 | Methoxychlor | Methoxychlor promotes the reaction [ESR1 protein binds to HOXA10 gene] | affects binding|increases reaction | 15890768 |
| D008731 | Methoxychlor | Methoxychlor results in increased activity of ESR1 protein | increases activity | 15064155 11485867 12623674 |
| D008731 | Methoxychlor | Methoxychlor results in increased expression of ESR1 mRNA | increases expression | 11922773 |
| D008731 | Methoxychlor | [o,p'-DDT co-treated with Methoxychlor co-treated with Dieldrin] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 11922773 |
| D008731 | Methoxychlor | PD 98059 inhibits the reaction [[Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]] | affects activity|decreases reaction|increases activity|increases reaction | 14975756 |
| D008731 | Methoxychlor | Tamoxifen inhibits the reaction [[Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]] | affects activity|decreases reaction|increases activity|increases reaction | 14975756 |
| D008731 | Methoxychlor | Methoxychlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| D008731 | Methoxychlor | ESR1 protein results in increased susceptibility to Methoxychlor | increases response to substance | 16787999 |
| D008731 | Methoxychlor | [Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of ESR1 mRNA | affects cotreatment|decreases expression | 11509743 |
| D008731 | Methoxychlor | Methoxychlor metabolite results in decreased expression of ESR1 mRNA | decreases expression | 11509743 |
| D008731 | Methoxychlor | Methoxychlor results in increased expression of ESR1 mRNA | increases expression | 8829249 |
| D008731 | Methoxychlor | Methoxychlor binds to ESR1 protein | affects binding | 11162928 |
| D008731 | Methoxychlor | Methoxychlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9171990 |
| D008731 | Methoxychlor | [Genistein co-treated with Methoxychlor] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 16443925 |
| D008731 | Methoxychlor | [Methoxychlor co-treated with Genistein] results in increased expression of ESR1 protein | affects cotreatment|increases expression | 11896288 |
| D008731 | Methoxychlor | Methoxychlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 10580743 |
| D008731 | Methoxychlor | Methoxychlor metabolite binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 10579340 |
| D008731 | Methoxychlor | Methoxychlor metabolite promotes the reaction [ESR1 protein binds to NCOA1 protein] | affects binding|increases reaction | 14613717 |
| D008731 | Methoxychlor | Methoxychlor binds to ESR1 protein | affects binding | 16787999 |
| D008731 | Methoxychlor | Methoxychlor metabolite binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 11509743 |
| D008731 | Methoxychlor | Methoxychlor metabolite binds to ESR1 protein | affects binding | 14664857 |
| C005219 | methyl cellosolve | methyl cellosolve results in increased expression of ESR1 mRNA | increases expression | 19643169 |
| D008748 | Methylcholanthrene | fulvestrant inhibits the reaction [Methylcholanthrene results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 16489053 |
| D008748 | Methylcholanthrene | Methylcholanthrene binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16972788 |
| D008748 | Methylcholanthrene | Methylcholanthrene binds to ESR1 protein | affects binding | 16489053 |
| D008748 | Methylcholanthrene | Methylcholanthrene promotes the reaction [ESR1 protein binds to CYP1A1 promoter] | affects binding|increases reaction | 16489053 |
| D008748 | Methylcholanthrene | Methylcholanthrene results in increased activity of ESR1 protein | increases activity | 16257430 |
| D008748 | Methylcholanthrene | Methylcholanthrene results in increased expression of ESR1 mRNA | increases expression | 16489053 |
| D008770 | Methylnitrosourea | ESR1 protein results in increased susceptibility to Methylnitrosourea | increases response to substance | 15528971 |
| D008770 | Methylnitrosourea | [Methylnitrosourea co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of ESR1 protein | affects cotreatment|decreases expression | 16891317 |
| D008743 | Methyl Parathion | Methyl Parathion binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9460653 |
| C008493 | methylselenic acid | [methylselenic acid co-treated with 4-hydroxytamoxifen] results in decreased expression of ESR1 mRNA | affects cotreatment|decreases expression | 16093440 |
| C008493 | methylselenic acid | [methylselenic acid co-treated with 4-hydroxytamoxifen] results in decreased expression of ESR1 protein | affects cotreatment|decreases expression | 16093440 |
| C008493 | methylselenic acid | methylselenic acid inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 15833885 |
| C008493 | methylselenic acid | methylselenic acid results in decreased expression of and results in decreased activity of ESR1 protein | decreases activity|decreases expression | 15833885 |
| C008493 | methylselenic acid | methylselenic acid results in decreased expression of ESR1 mRNA | decreases expression | 16155795 16093440 15833885 |
| C008493 | methylselenic acid | methylselenic acid results in decreased expression of ESR1 protein | decreases expression | 16155795 16093440 |
| D008777 | Methyltestosterone | Methyltestosterone results in increased activity of ESR1 protein | increases activity | 12504345 |
| C517398 | MF101 extract | MF101 extract binds to ESR1 protein | affects binding | 17095596 |
| D015735 | Mifepristone | Mifepristone binds to ESR1 protein | affects binding | 15001543 |
| C016599 | mono-(2-ethylhexyl)phthalate | mono-(2-ethylhexyl)phthalate binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 20209442 |
| C035359 | monorden | monorden analog results in decreased expression of ESR1 protein | decreases expression | 11448926 |
| C035359 | monorden | monorden results in decreased expression of ESR1 protein | decreases expression | 11448926 |
| C011310 | moxestrol | moxestrol promotes the reaction [ESR1 protein binds to SERPINB9 protein] | affects binding|increases reaction | 14617632 |
| C011310 | moxestrol | moxestrol promotes the reaction [ESR1 protein binds to TFF1 protein] | affects binding|increases reaction | 14617632 |
| C011310 | moxestrol | moxestrol results in increased activity of ESR1 protein | increases activity | 10875235 |
| C011310 | moxestrol | moxestrol binds to ESR1 protein | affects binding | 15001543 |
| C063509 | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cyclic AMP results in increased activity of ESR1 protein] | decreases reaction|increases activity | 20360387 |
| C046170 | naphthenic acid | naphthenic acid binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 19924924 |
| C005273 | naringenin | naringenin binds to ESR1 protein | affects binding | 11162928 |
| C005273 | naringenin | naringenin results in increased activity of ESR1 protein | increases activity | 18980245 |
| C005273 | naringenin | naringenin binds to ESR1 protein | affects binding | 11162928 |
| C005273 | naringenin | fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein] | affects binding|decreases reaction|increases activity | 12650720 |
| C005273 | naringenin | naringenin affects the activity of ESR1 protein | affects activity | 15185748 |
| C005273 | naringenin | naringenin binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9751507 10397250 |
| C005273 | naringenin | [naringenin binds to ESR1 protein] which results in increased activity of ALPL protein | affects binding|increases activity | 12650720 |
| C005273 | naringenin | naringenin promotes the reaction [ESR1 protein binds to ESR1 protein] | affects binding|increases reaction | 15713566 |
| C005273 | naringenin | naringenin results in increased activity of ESR1 protein | increases activity | 10854714 16118406 |
| C005273 | naringenin | naringenin binds to ESR1 protein | affects binding | 11162928 |
| C028787 | N-desmethyltamoxifen | 4-hydroxy-N-desmethyltamoxifen inhibits the reaction [[Tamoxifen co-treated with N-desmethyltamoxifen co-treated with 4-hydroxytamoxifen] results in increased stability of ESR1 protein] | affects cotreatment|decreases reaction|increases stability | 19244106 |
| C028787 | N-desmethyltamoxifen | [Tamoxifen co-treated with N-desmethyltamoxifen co-treated with 4-hydroxytamoxifen] results in increased stability of ESR1 protein | affects cotreatment|increases stability | 19244106 |
| C007350 | nitrofen | nitrofen binds to ESR1 protein | affects binding | 15253041 |
| D009599 | Nitroprusside | ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Nitroprusside] | affects cotreatment|affects response to substance | 17158209 |
| D009599 | Nitroprusside | ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Nitroprusside] | affects cotreatment|affects response to substance | 17158209 |
| C004845 | N,N'-diphenyl-4-phenylenediamine | N,N'-diphenyl-4-phenylenediamine results in increased activity of ESR1 protein | increases activity | 12504345 |
| C001870 | nonachlor | nonachlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| C001870 | nonachlor | nonachlor binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16626760 |
| C001870 | nonachlor | nonachlor binds to ESR1 protein | affects binding | 14579009 |
| C001870 | nonachlor | nonachlor inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| C025256 | nonylphenol | [nonylphenol co-treated with Tamoxifen] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 19456386 |
| C025256 | nonylphenol | nonylphenol results in increased expression of ESR1 mRNA | increases expression | 19456386 |
| C025256 | nonylphenol | 4-hydroxytamoxifen inhibits the reaction [nonylphenol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 14754635 |
| C025256 | nonylphenol | hydroxytamoxifen inhibits the reaction [nonylphenol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 14709801 |
| C025256 | nonylphenol | nonylphenol affects the activity of ESR1 protein | affects activity | 18635651 |
| C025256 | nonylphenol | nonylphenol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 14709801 9751507 |
| C025256 | nonylphenol | nonylphenol binds to ESR1 protein | affects binding | 10492897 14579009 |
| C025256 | nonylphenol | [nonylphenol binds to ESR1 protein] which results in increased activity of ALPL protein | affects binding|increases activity | 12650720 |
| C025256 | nonylphenol | nonylphenol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| C025256 | nonylphenol | nonylphenol metabolite binds to ESR1 protein | affects binding | 10492897 |
| C025256 | nonylphenol | nonylphenol results in decreased expression of ESR1 mRNA | decreases expression | 14709801 |
| C025256 | nonylphenol | nonylphenol results in decreased expression of ESR1 protein | decreases expression | 14754635 14709801 |
| C025256 | nonylphenol | nonylphenol results in increased activity of and results in increased localization of ESR1 protein | increases activity|increases localization | 14754635 |
| C025256 | nonylphenol | nonylphenol results in increased activity of ESR1 protein | increases activity | 14975756 16756374 |
| C025256 | nonylphenol | [nonylphenol results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA | increases activity|increases expression | 14754635 |
| C025256 | nonylphenol | [nonylphenol results in increased activity of ESR1 protein] which results in increased expression of TFF1 mRNA | increases activity|increases expression | 14754635 |
| C025256 | nonylphenol | nonylphenol binds to ESR1 protein | affects binding | 9439733 |
| C025256 | nonylphenol | nonylphenol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| C025256 | nonylphenol | nonylphenol results in increased expression of ESR1 protein | increases expression | 9439733 |
| C025256 | nonylphenol | 3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [nonylphenol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 16291559 |
| C025256 | nonylphenol | 4-hydroxytamoxifen inhibits the reaction [nonylphenol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 8800639 |
| C025256 | nonylphenol | ICI 164384 inhibits the reaction [nonylphenol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 8800639 |
| C025256 | nonylphenol | nonylphenol results in increased expression of ESR1 mRNA | increases expression | 16291559 8800639 |
| C025256 | nonylphenol | nonylphenol results in increased expression of ESR1 mRNA | increases expression | 19009365 |
| C025256 | nonylphenol | nonylphenol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9171990 |
| C025256 | nonylphenol | nonylphenol results in increased expression of ESR1 mRNA | increases expression | 15820104 |
| C025256 | nonylphenol | nonylphenol binds to ESR1 protein | affects binding | 11086226 |
| C025256 | nonylphenol | nonylphenol results in increased activity of ESR1 protein | increases activity | 12504345 |
| C025256 | nonylphenol | nonylphenol results in increased expression of ESR1 mRNA | increases expression | 12062901 |
| C025256 | nonylphenol | nonylphenol results in increased expression of ESR1 protein | increases expression | 11731036 |
| D004963 | Estrenes | Estrenes analog binds to and affects the activity of ESR1 protein | affects activity|affects binding | 15219790 |
| D004963 | Estrenes | Estrenes analog results in decreased expression of ESR1 mRNA | decreases expression | 15219790 |
| D009640 | Norethindrone | Norethindrone results in increased activity of ESR1 protein | increases activity | 11750080 12504345 |
| D009640 | Norethindrone | Norethindrone results in increased activity of ESR1 protein | increases activity | 10836199 |
| D009641 | Norethynodrel | Norethynodrel results in increased activity of ESR1 protein | increases activity | 10836199 |
| C100284 | norgestomet | norgestomet results in decreased expression of ESR1 mRNA | decreases expression | 10954858 |
| C100284 | norgestomet | norgestomet results in decreased expression of ESR1 protein | decreases expression | 10954858 |
| D009644 | Norgestrel | Norgestrel results in increased activity of ESR1 protein | increases activity | 11750080 12504345 |
| C088673 | octocrylene | octocrylene binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16079615 |
| C474055 | octylphenol | [octylphenol binds to ESR1 protein] which results in increased activity of ALPL protein | affects binding|increases activity | 12650720 |
| C474055 | octylphenol | fulvestrant inhibits the reaction [octylphenol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 18417718 |
| C474055 | octylphenol | octylphenol results in increased activity of ESR1 protein | increases activity | 18417718 |
| C474055 | octylphenol | octylphenol results in decreased expression of ESR1 mRNA | decreases expression | 15070829 |
| C474055 | octylphenol | octylphenol results in increased expression of ESR1 mRNA | increases expression | 12062901 |
| C050052 | O-desmethylangolensin | Estradiol affects the reaction [O-desmethylangolensin affects the activity of ESR1 protein] | affects activity|affects reaction | 16965913 |
| D019319 | Okadaic Acid | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Okadaic Acid results in increased degradation of ESR1 mRNA] | decreases reaction|increases degradation | 15965230 |
| D019319 | Okadaic Acid | Okadaic Acid results in decreased expression of ESR1 protein | decreases expression | 15965230 |
| D019319 | Okadaic Acid | Okadaic Acid results in increased degradation of and results in decreased expression of ESR1 mRNA | decreases expression|increases degradation | 15965230 |
| C016340 | o,p'-DDT | [o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9118873 |
| C016340 | o,p'-DDT | [o,p'-DDT co-treated with Dicofol] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9118873 |
| C016340 | o,p'-DDT | o,p'-DDT inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9118873 |
| C016340 | o,p'-DDT | o,p'-DDT results in increased activity of ESR1 protein | increases activity | 18980245 |
| C016340 | o,p'-DDT | o,p'-DDT binds to ESR1 protein | affects binding | 11162928 |
| C016340 | o,p'-DDT | [Estradiol co-treated with Genistein co-treated with o,p'-DDT] affects the expression of ESR1 mRNA | affects cotreatment|affects expression | 11922773 |
| C016340 | o,p'-DDT | o,p'-DDT binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9751507 16626760 12676605 |
| C016340 | o,p'-DDT | o,p'-DDT binds to ESR1 protein | affects binding | 14579009 12676605 |
| C016340 | o,p'-DDT | [o,p'-DDT co-treated with Methoxychlor co-treated with Dieldrin] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 11922773 |
| C016340 | o,p'-DDT | o,p'-DDT inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 8930550 14579009 |
| C016340 | o,p'-DDT | o,p'-DDT results in decreased expression of ESR1 protein | decreases expression | 11867264 |
| C016340 | o,p'-DDT | o,p'-DDT results in increased activity of ESR1 protein | increases activity | 15064155 |
| C016340 | o,p'-DDT | o,p'-DDT results in increased expression of ESR1 mRNA | increases expression | 11922773 |
| C016340 | o,p'-DDT | o,p'-DDT inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| C016340 | o,p'-DDT | o,p'-DDT binds to ESR1 protein | affects binding | 11162928 |
| C016340 | o,p'-DDT | o,p'-DDT binds to ESR1 protein | affects binding | 11944962 11162928 |
| C016340 | o,p'-DDT | o,p'-DDT inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9171990 |
| C016340 | o,p'-DDT | o,p'-DDT binds to ESR1 protein | affects binding | 11086226 |
| C016340 | o,p'-DDT | o,p'-DDT binds to ESR1 protein | affects binding | 11944962 |
| C508548 | ormeloxifene | [Estradiol co-treated with ormeloxifene] promotes the reaction [NCOR1 protein binds to ESR1 protein] | affects binding|affects cotreatment|increases reaction | 19460436 |
| C508548 | ormeloxifene | [Estradiol co-treated with ormeloxifene] promotes the reaction [NRIP1 protein binds to ESR1 protein] | affects binding|affects cotreatment|increases reaction | 19460436 |
| C508548 | ormeloxifene | [Estradiol co-treated with ormeloxifene] results in decreased expression of ESR1 protein | affects cotreatment|decreases expression | 19460436 |
| C508548 | ormeloxifene | ormeloxifene inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]] | affects binding|decreases reaction|increases reaction | 19460436 |
| C508548 | ormeloxifene | ormeloxifene promotes the reaction [NCOR1 protein binds to ESR1 protein] | affects binding|increases reaction | 19460436 |
| C011960 | oxamyl | oxamyl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 9126867 |
| C005290 | oxybenzone | oxybenzone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16079615 |
| C005290 | oxybenzone | oxybenzone results in decreased expression of ESR1 mRNA | decreases expression | 15458797 |
| D010100 | Oxygen | Oxygen deficiency results in decreased expression of ESR1 protein | decreases expression | 19578757 |
| D010100 | Oxygen | [Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased activity of ESR1 protein | affects cotreatment|increases activity | 19578757 |
| D010100 | Oxygen | Oxygen deficiency results in increased expression of ESR1 protein | increases expression | 15927375 |
| D017239 | Paclitaxel | alitretinoin inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 19340624 |
| D017239 | Paclitaxel | beta Carotene inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 19340624 |
| D017239 | Paclitaxel | Paclitaxel results in increased expression of ESR1 mRNA | increases expression | 19340624 |
| D017239 | Paclitaxel | Vitamin A inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 19340624 |
| C093973 | PD 98059 | PD 98059 inhibits the reaction [[bisphenol A affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]] | affects activity|decreases reaction|increases activity|increases reaction | 14975756 |
| C093973 | PD 98059 | PD 98059 inhibits the reaction [EGF protein affects the localization of ESR1 protein] | affects localization|decreases reaction | 15947004 |
| C093973 | PD 98059 | PD 98059 inhibits the reaction [[Endosulfan affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]] | affects activity|decreases reaction|increases activity|increases reaction | 14975756 |
| C093973 | PD 98059 | PD 98059 inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein] | decreases reaction|increases phosphorylation | 15615701 |
| C093973 | PD 98059 | PD 98059 inhibits the reaction [[Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]] | affects activity|decreases reaction|increases activity|increases reaction | 14975756 |
| C093973 | PD 98059 | PD 98059 inhibits the reaction [resveratrol results in increased phosphorylation of ESR1 protein] | decreases reaction|increases phosphorylation | 15615701 |
| C093973 | PD 98059 | PD 98059 inhibits the reaction [Estradiol results in increased expression of ESR1 protein] | decreases reaction|increases expression | 19340542 |
| C093973 | PD 98059 | PD 98059 results in decreased expression of ESR1 protein | decreases expression | 19340542 |
| C030856 | pendimethalin | pendimethalin results in increased activity of ESR1 protein | increases activity | 15064155 |
| C086401 | pentabromodiphenyl ether | pentabromodiphenyl ether results in increased expression of ESR1 mRNA | increases expression | 16414171 |
| D010416 | Pentachlorophenol | Pentachlorophenol binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 16626760 |
| D010416 | Pentachlorophenol | Pentachlorophenol inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9171990 |
| D010420 | Pentanes | Pentanes results in increased activity of ESR1 protein | increases activity | 12504345 |
| C023036 | perfluorooctanoic acid | perfluorooctanoic acid results in increased expression of ESR1 mRNA | increases expression | 18709148 |
| D026023 | Permethrin | Permethrin metabolite binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16395479 |
| D026023 | Permethrin | Permethrin results in increased activity of ESR1 protein | increases activity | 15064155 |
| D026023 | Permethrin | Permethrin binds to ESR1 protein | affects binding | 12396874 |
| D037342 | Pertussis Toxin | Pertussis Toxin inhibits the reaction [Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]] | decreases reaction|increases activity | 15813899 |
| C031181 | phenanthrene | phenanthrene analog binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 12672240 |
| D010636 | Phenols | Phenols analog binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15952375 |
| D010636 | Phenols | Phenols analog binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15952375 |
| C006166 | phenothrin | phenothrin results in decreased expression of ESR1 protein | decreases expression | 15118252 |
| C008838 | phenthoate | phenthoate results in increased activity of ESR1 protein | increases activity | 15064155 |
| D010656 | Phenylephrine | ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine] | affects cotreatment|affects response to substance | 17158209 |
| D010656 | Phenylephrine | ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Acetylcholine] | affects cotreatment|affects response to substance | 17158209 |
| D010656 | Phenylephrine | ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Nitroprusside] | affects cotreatment|affects response to substance | 17158209 |
| D004849 | Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester | Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester results in increased activity of ESR1 protein | increases activity | 15064155 |
| D010672 | Phenytoin | Phenytoin results in increased expression of ESR1 mRNA | increases expression | 19490052 |
| D010672 | Phenytoin | Phenytoin results in increased expression of ESR1 protein | increases expression | 19490052 |
| D010693 | Phloretin | Phloretin binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9751507 |
| D017905 | Phosphites | Phosphites results in increased activity of ESR1 protein | increases activity | 16756374 |
| C032279 | phthalic acid | phthalic acid analog binds to ESR1 protein | affects binding | 14579009 |
| C032279 | phthalic acid | phthalic acid analog inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| C032279 | phthalic acid | phthalic acid binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15840436 |
| C032279 | phthalic acid | Tamoxifen inhibits the reaction [phthalic acid metabolite binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 15840436 |
| D010795 | Phthalic Acids | Phthalic Acids results in increased activity of ESR1 protein | increases activity | 16756374 |
| C100185 | phytoene | [phytoene co-treated with phytofluene] inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | affects cotreatment|decreases reaction|increases activity | 17051425 |
| D048789 | Phytoestrogens | Phytoestrogens binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16076101 |
| D048789 | Phytoestrogens | Phytoestrogens results in decreased expression of ESR1 mRNA | decreases expression | 16033089 |
| D048789 | Phytoestrogens | Phytoestrogens results in decreased expression of ESR1 protein | decreases expression | 16033089 |
| D048789 | Phytoestrogens | Phytoestrogens results in decreased expression of ESR1 mRNA | decreases expression | 16731787 |
| D048789 | Phytoestrogens | Phytoestrogens results in increased expression of ESR1 mRNA | increases expression | 16731787 |
| C003140 | phytofluene | [phytoene co-treated with phytofluene] inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | affects cotreatment|decreases reaction|increases activity | 17051425 |
| C049032 | pinosylvin | pinosylvin binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 18348622 |
| C011994 | pirimicarb | pirimicarb results in decreased expression of ESR1 mRNA | decreases expression | 15261991 |
| C014153 | pirimiphos methyl | pirimiphos methyl results in increased activity of ESR1 protein | increases activity | 15064155 |
| C006253 | pirinixic acid | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ESR1 mRNA | affects binding|decreases expression|increases activity | 19710929 |
| D010936 | Plant Extracts | Plant Extracts binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16076101 |
| D010936 | Plant Extracts | Plant Extracts binds to ESR1 protein | affects binding | 16566672 11368622 14706564 |
| D010936 | Plant Extracts | [Plant Extracts binds to ESR1 protein] which results in increased activity of ALPL protein | affects binding|increases activity | 12650720 |
| D010936 | Plant Extracts | Plant Extracts inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 16566672 11368622 |
| D010936 | Plant Extracts | Plant Extracts inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 20559769 |
| D010936 | Plant Extracts | Plant Extracts promotes the reaction [Tamoxifen inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ESR1 mRNA]] | decreases reaction|increases expression|increases reaction | 20559769 |
| D028321 | Plant Preparations | Plant Preparations results in increased activity of ESR1 protein | increases activity | 17935960 |
| D028321 | Plant Preparations | Plant Preparations results in increased expression of ESR1 protein | increases expression | 17398067 |
| D008926 | Plicamycin | Plicamycin inhibits the reaction [4-hydroxytamoxifen promotes the reaction [ESR1 protein binds to CDH1 promoter]] | affects binding|decreases reaction|increases reaction | 19593637 |
| D011075 | Polybrominated Biphenyls | Polybrominated Biphenyls analog binds to ESR1 protein | affects binding | 11693576 |
| D011078 | Polychlorinated Biphenyls | Polychlorinated Biphenyls results in decreased expression of ESR1 mRNA | decreases expression | 16962596 |
| D011078 | Polychlorinated Biphenyls | Polychlorinated Biphenyls metabolite inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 12377985 |
| D011078 | Polychlorinated Biphenyls | Polychlorinated Biphenyls binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16079073 |
| D011078 | Polychlorinated Biphenyls | [Polychlorinated Biphenyls co-treated with chlorinated dibenzofurans co-treated with polychlorodibenzo-4-dioxin analog] results in decreased expression of ESR1 mRNA | affects cotreatment|decreases expression | 12883090 |
| D011078 | Polychlorinated Biphenyls | [Polychlorinated Biphenyls co-treated with polychlorodibenzo-4-dioxin co-treated with chlorinated dibenzofurans] results in decreased expression of ESR1 mRNA | affects cotreatment|decreases expression | 15858227 |
| C008954 | polychlorodibenzo-4-dioxin | [Polychlorinated Biphenyls co-treated with chlorinated dibenzofurans co-treated with polychlorodibenzo-4-dioxin analog] results in decreased expression of ESR1 mRNA | affects cotreatment|decreases expression | 12883090 |
| C008954 | polychlorodibenzo-4-dioxin | [Polychlorinated Biphenyls co-treated with polychlorodibenzo-4-dioxin co-treated with chlorinated dibenzofurans] results in decreased expression of ESR1 mRNA | affects cotreatment|decreases expression | 15858227 |
| D011188 | Potassium | ESR1 protein promotes the reaction [Estradiol inhibits the reaction [Potassium results in increased secretion of gamma-Aminobutyric Acid]] | decreases reaction|increases reaction|increases secretion | 19211896 |
| C023617 | pregna-4,17-diene-3,16-dione | pregna-4,17-diene-3,16-dione results in increased activity of ESR1 protein | increases activity | 15075359 |
| C045362 | prochloraz | fulvestrant inhibits the reaction [prochloraz results in decreased expression of ESR1 mRNA] | decreases expression|decreases reaction | 15130599 |
| C045362 | prochloraz | prochloraz inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA] | decreases expression|decreases reaction | 15261991 |
| C045362 | prochloraz | prochloraz results in decreased expression of ESR1 mRNA | decreases expression | 15130599 |
| C045362 | prochloraz | prochloraz results in decreased expression of ESR1 protein | decreases expression | 15130599 |
| C045362 | prochloraz | prochloraz results in decreased expression of ESR1 mRNA | decreases expression | 18800561 |
| D011374 | Progesterone | Progesterone affects the expression of ESR1 protein | affects expression | 16483645 |
| D011374 | Progesterone | Progesterone results in decreased expression of ESR1 mRNA | decreases expression | 18037150 |
| D011374 | Progesterone | Progesterone inhibits the reaction [ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]] | decreases reaction|increases expression|increases reaction | 17974624 |
| D011374 | Progesterone | [Progesterone co-treated with Estradiol] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 15829624 |
| D011374 | Progesterone | Progesterone results in increased expression of ESR1 mRNA | increases expression | 15829624 |
| D011374 | Progesterone | bisphenol A inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ESR1 protein] | affects cotreatment|decreases reaction|increases expression | 18653720 |
| D011374 | Progesterone | Diethylstilbestrol inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ESR1 protein] | affects cotreatment|decreases reaction|increases expression | 18653720 |
| D011374 | Progesterone | [Estradiol co-treated with Progesterone] results in decreased expression of ESR1 mRNA alternative form | affects cotreatment|decreases expression | 16002535 |
| D011374 | Progesterone | [Estradiol co-treated with Progesterone] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 18653720 |
| D011374 | Progesterone | Progesterone results in decreased expression of ESR1 mRNA | decreases expression | 16002535 |
| D011374 | Progesterone | Progesterone results in decreased expression of ESR1 mRNA alternative form | decreases expression | 16002535 |
| D011374 | Progesterone | Progesterone results in decreased expression of ESR1 protein | decreases expression | 16002535 |
| D001074 | Propoxur | Propoxur inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 9126867 |
| D011435 | Propyl Gallate | Propyl Gallate results in increased activity of ESR1 protein | increases activity | 16756374 |
| C467746 | propyl pyrazole triol | propyl pyrazole triol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15585566 15207704 |
| C467746 | propyl pyrazole triol | [propyl pyrazole triol co-treated with ESR1 protein] results in increased expression of IGFBP4 mRNA | affects cotreatment|increases expression | 12399409 |
| C467746 | propyl pyrazole triol | propyl pyrazole triol results in increased activity of ESR1 protein | increases activity | 17935960 |
| C467746 | propyl pyrazole triol | propyl pyrazole triol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 18446233 15465114 |
| C467746 | propyl pyrazole triol | [propyl pyrazole triol binds to and results in increased activity of ESR1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein | affects binding|increases activity|increases phosphorylation | 18446233 |
| C467746 | propyl pyrazole triol | [propyl pyrazole triol binds to and results in increased activity of ESR1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein | affects binding|increases activity|increases phosphorylation | 18446233 |
| C467746 | propyl pyrazole triol | propyl pyrazole triol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15910780 |
| C467746 | propyl pyrazole triol | propyl pyrazole triol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15912132 15615701 |
| C435023 | proteolipid protein 139-151 | proteolipid protein 139-151 binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15845917 |
| C032072 | prothiophos | prothiophos results in increased activity of ESR1 protein | increases activity | 15064155 |
| C031280 | pyrazole | pyrazole analog binds to ESR1 protein | affects binding | 17909483 |
| D011720 | Pyrazoles | Pyrazoles analog binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 19772920 |
| C043100 | pyridate | pyridate binds to ESR1 protein | affects binding | 15253041 |
| C043100 | pyridate | pyridate inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 15253041 |
| D011794 | Quercetin | Quercetin binds to ESR1 protein | affects binding | 11162928 |
| D011794 | Quercetin | Quercetin binds to ESR1 protein | affects binding | 11162928 |
| D011794 | Quercetin | Estradiol affects the reaction [Quercetin results in increased activity of ESR1 protein] | affects reaction|increases activity | 16118406 |
| D011794 | Quercetin | Quercetin affects the activity of ESR1 protein | affects activity | 15185748 |
| D011794 | Quercetin | Quercetin binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 11502892 9751507 15182386 15937998 |
| D011794 | Quercetin | Quercetin binds to ESR1 protein | affects binding | 14706564 |
| D011794 | Quercetin | Quercetin results in decreased expression of ESR1 mRNA | decreases expression | 11502892 |
| D011794 | Quercetin | Quercetin results in decreased expression of ESR1 protein | decreases expression | 11502892 |
| D011794 | Quercetin | Quercetin results in increased activity of ESR1 protein | increases activity | 16118406 |
| D011794 | Quercetin | Quercetin binds to ESR1 protein | affects binding | 11162928 |
| C009145 | quinalphos | quinalphos results in increased activity of ESR1 protein | increases activity | 15064155 |
| D020849 | Raloxifene | ARID5A protein inhibits the reaction [Raloxifene results in increased activity of ESR1 protein] | decreases reaction|increases activity | 15941852 |
| D020849 | Raloxifene | ESR1 exon polymorphism results in increased susceptibility to Raloxifene | increases response to substance | 17350824 |
| D020849 | Raloxifene | ESR1 gene polymorphism affects the susceptibility to Raloxifene | affects response to substance | 15807179 16604479 |
| D020849 | Raloxifene | ESR1 protein affects the reaction [Raloxifene results in decreased expression of EMP1 mRNA] | affects reaction|decreases expression | 14699072 |
| D020849 | Raloxifene | ESR1 protein affects the reaction [Raloxifene results in decreased expression of HSPA1B mRNA] | affects reaction|decreases expression | 14699072 |
| D020849 | Raloxifene | ESR1 protein affects the reaction [Raloxifene results in decreased expression of MFAP5 mRNA] | affects reaction|decreases expression | 14699072 |
| D020849 | Raloxifene | ESR1 protein affects the reaction [Raloxifene results in increased expression of IDH2 mRNA] | affects reaction|increases expression | 14699072 |
| D020849 | Raloxifene | ESR1 protein affects the reaction [Raloxifene results in increased expression of KLRC2 mRNA] | affects reaction|increases expression | 14699072 |
| D020849 | Raloxifene | ESR1 protein affects the reaction [Raloxifene results in increased expression of KLRC3 mRNA] | affects reaction|increases expression | 17395694 |
| D020849 | Raloxifene | ESR1 protein affects the reaction [Raloxifene results in increased expression of PPAP2B mRNA] | affects reaction|increases expression | 14699072 |
| D020849 | Raloxifene | ESR1 protein affects the reaction [Raloxifene results in increased expression of TGFB3 mRNA] | affects reaction|increases expression | 14699072 |
| D020849 | Raloxifene | ESR1 protein affects the reaction [Raloxifene results in increased expression of ZFP36 mRNA] | affects reaction|increases expression | 14699072 |
| D020849 | Raloxifene | ESR1 protein promotes the reaction [Raloxifene results in increased activity of TERT protein] | increases activity|increases reaction | 16798746 |
| D020849 | Raloxifene | Raloxifene affects the folding of and affects the activity of ESR1 protein | affects activity|affects folding | 17299137 |
| D020849 | Raloxifene | Raloxifene affects the folding of ESR1 protein | affects folding | 16497877 |
| D020849 | Raloxifene | Raloxifene binds to ESR1 protein | affects binding | 17203231 15842231 9751507 15961563 15521089 |
| D020849 | Raloxifene | [Raloxifene binds to ESR1 protein] which binds to SERPINB9 protein | affects binding | 14617632 |
| D020849 | Raloxifene | [Raloxifene binds to ESR1 protein] which binds to TFF1 protein | affects binding | 14617632 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in decreased expression of ANKRD28 mRNA | affects cotreatment|decreases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in decreased expression of CSF2 mRNA | affects cotreatment|decreases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in decreased expression of ENC1 mRNA | affects cotreatment|decreases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in decreased expression of HAS2 mRNA | affects cotreatment|decreases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in decreased expression of KCNN4 mRNA | affects cotreatment|decreases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in decreased expression of LMCD1 mRNA | affects cotreatment|decreases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in decreased expression of NCRNA00312 mRNA | affects cotreatment|decreases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in decreased expression of NOV mRNA | affects cotreatment|decreases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in decreased expression of PLAU mRNA | affects cotreatment|decreases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in decreased expression of RGS16 mRNA | affects cotreatment|decreases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in decreased expression of SLN mRNA | affects cotreatment|decreases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in decreased expression of TGFBI mRNA | affects cotreatment|decreases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in decreased expression of TNFRSF11B mRNA | affects cotreatment|decreases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in decreased expression of TXNIP mRNA | affects cotreatment|decreases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of C6ORF32 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of CA12 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of CRISPLD2 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of EDNRA mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of EIF1 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of ENPP2 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of FHL2 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of G0S2 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of GOLSYN mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of GRK5 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of HEG1 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of HK1 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of IDH2 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of ISG20 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of KCTD12 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of KLRC2 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of LPL mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of MSMB mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of NLRP3 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of NPR2 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of OSBPL3 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of PFKFB3 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of PTPRE mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of RASGRP1 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of RET mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of RGS4 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of RHOBTB3 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of SEMA3B mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of SGK1 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of TIPARP mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of TMOD1 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of TMPRSS3 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of ZNF395 mRNA | affects cotreatment|increases expression | 19059307 |
| D020849 | Raloxifene | Raloxifene inhibits the reaction [ESR1 protein binds to CCL3 promoter] | affects binding|decreases reaction | 16497877 |
| D020849 | Raloxifene | Raloxifene inhibits the reaction [ESR1 protein binds to RELA protein] | affects binding|decreases reaction | 16497877 |
| D020849 | Raloxifene | Raloxifene inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9751507 |
| D020849 | Raloxifene | Raloxifene promotes the reaction [ESR1 protein binds to IGF1 promoter] | affects binding|increases reaction | 17872375 |
| D020849 | Raloxifene | Raloxifene promotes the reaction [ESR1 protein binds to KLRC3 gene] | affects binding|increases reaction | 17395694 |
| D020849 | Raloxifene | Raloxifene promotes the reaction [ESR1 protein binds to PTGS2 promoter] | affects binding|increases reaction | 17872375 |
| D020849 | Raloxifene | Raloxifene results in decreased activity of ESR1 protein | decreases activity | 17654759 |
| D020849 | Raloxifene | Raloxifene results in decreased expression of ESR1 protein | decreases expression | 11867264 |
| D020849 | Raloxifene | Raloxifene results in increased expression of ESR1 mRNA | increases expression | 19432593 |
| D020849 | Raloxifene | Raloxifene binds to ESR1 protein | affects binding | 15161930 |
| D020849 | Raloxifene | Raloxifene affects the expression of ESR1 mRNA | affects expression | 19350480 |
| D020849 | Raloxifene | Raloxifene metabolite binds to ESR1 protein | affects binding | 16790557 |
| D020849 | Raloxifene | Raloxifene affects the expression of ESR1 protein | affects expression | 16680078 15653758 |
| D020849 | Raloxifene | Raloxifene metabolite binds to ESR1 protein | affects binding | 16790557 |
| D020849 | Raloxifene | Raloxifene results in decreased expression of ESR1 protein alternative form | decreases expression | 17348974 |
| D020849 | Raloxifene | Raloxifene binds to ESR1 protein | affects binding | 16679488 |
| C059514 | resveratrol | resveratrol results in increased phosphorylation of ESR1 protein | increases phosphorylation | 15615701 |
| C059514 | resveratrol | AG 1879 inhibits the reaction [resveratrol affects the localization of ESR1 protein] | affects localization|decreases reaction | 17513867 |
| C059514 | resveratrol | AG 1879 inhibits the reaction [resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]] | affects binding|decreases reaction|increases reaction | 17513867 |
| C059514 | resveratrol | AG 1879 inhibits the reaction [resveratrol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 17513867 |
| C059514 | resveratrol | AG 1879 inhibits the reaction [resveratrol results in increased phosphorylation of ESR1 protein] | decreases reaction|increases phosphorylation | 15615701 |
| C059514 | resveratrol | ESR1 protein affects the reaction [resveratrol affects the secretion of CTSD protein] | affects reaction|affects secretion | 16393696 |
| C059514 | resveratrol | ESR1 protein affects the reaction [resveratrol results in increased expression of VDR mRNA] | affects reaction|increases expression | 15664452 |
| C059514 | resveratrol | FOXA1 protein promotes the reaction [resveratrol results in increased activity of ESR1 protein] | increases activity|increases reaction | 17513867 |
| C059514 | resveratrol | fulvestrant inhibits the reaction [resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]] | affects binding|decreases reaction|increases reaction | 17513867 |
| C059514 | resveratrol | PD 98059 inhibits the reaction [resveratrol results in increased phosphorylation of ESR1 protein] | decreases reaction|increases phosphorylation | 15615701 |
| C059514 | resveratrol | resveratrol affects the localization of ESR1 protein | affects localization | 17513867 |
| C059514 | resveratrol | resveratrol binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 15084758 |
| C059514 | resveratrol | resveratrol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15876408 15120416 |
| C059514 | resveratrol | resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter] | affects binding|increases reaction | 17513867 |
| C059514 | resveratrol | resveratrol promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 16118406 |
| C059514 | resveratrol | resveratrol promotes the reaction [NCOA2 protein binds to ESR1 protein] | affects binding|increases reaction | 15084758 |
| C059514 | resveratrol | resveratrol results in decreased expression of ESR1 protein | decreases expression | 17486135 |
| C059514 | resveratrol | resveratrol results in increased activity of ESR1 protein | increases activity | 16118406 17513867 10854714 17935960 |
| C059514 | resveratrol | resveratrol results in increased activity of ESR1 protein mutant form | increases activity | 17141713 |
| C059514 | resveratrol | resveratrol results in increased phosphorylation of ESR1 protein | increases phosphorylation | 15615701 |
| C059514 | resveratrol | Tamoxifen inhibits the reaction [resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]] | affects binding|decreases reaction|increases reaction | 17513867 |
| C059514 | resveratrol | ESR1 protein results in increased susceptibility to resveratrol | increases response to substance | 17872969 |
| C059514 | resveratrol | resveratrol binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 18348622 |
| C059514 | resveratrol | resveratrol results in decreased expression of ESR1 mRNA | decreases expression | 11218048 |
| C059514 | resveratrol | resveratrol results in decreased expression of ESR1 protein | decreases expression | 11218048 |
| C059514 | resveratrol | resveratrol binds to ESR1 protein | affects binding | 16614383 |
| C431126 | rhapontigenin | rhapontigenin analog results in increased activity of ESR1 protein | increases activity | 17935960 |
| C058787 | royal jelly | Estradiol inhibits the reaction [royal jelly binds to ESR1 protein] | affects binding|decreases reaction | 17287592 |
| C058787 | royal jelly | royal jelly binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15946813 |
| C058787 | royal jelly | royal jelly binds to ESR1 protein | affects binding | 17287592 |
| C058787 | royal jelly | royal jelly inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 15946813 |
| C058787 | royal jelly | royal jelly results in increased activity of ESR1 protein | increases activity | 15946813 |
| C086511 | RU 58668 | RU 58668 results in decreased stability of and results in decreased expression of ESR1 protein | decreases expression|decreases stability | 15868441 |
| C005704 | salicylaldoxime | salicylaldoxime analog binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12954056 |
| C093642 | SB 203580 | SB 203580 inhibits the reaction [Estradiol results in increased expression of ESR1 protein] | decreases reaction|increases expression | 19340542 |
| C093642 | SB 203580 | SB 203580 results in decreased expression of ESR1 protein | decreases expression | 19340542 |
| C090142 | secoisolariciresinol diglucoside | secoisolariciresinol diglucoside results in decreased expression of ESR1 protein | decreases expression | 19904759 |
| D020845 | Selective Estrogen Receptor Modulators | HDAC4 protein inhibits the reaction [Selective Estrogen Receptor Modulators results in increased activity of ESR1 protein] | decreases reaction|increases activity | 16051668 |
| D020845 | Selective Estrogen Receptor Modulators | Selective Estrogen Receptor Modulators binds to and affects the folding of and results in decreased stability of and results in decreased activity of ESR1 protein | affects binding|affects folding|decreases activity|decreases stability | 15893725 |
| D020845 | Selective Estrogen Receptor Modulators | Selective Estrogen Receptor Modulators binds to and affects the activity of ESR1 protein | affects activity|affects binding | 15925950 |
| C002979 | selenomethylselenocysteine | [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of ESR1 protein | affects cotreatment|decreases expression | 18855134 |
| C002979 | selenomethylselenocysteine | selenomethylselenocysteine results in decreased expression of ESR1 protein | decreases expression | 18855134 |
| C440975 | silybin | silybin results in increased activity of [ESR1 protein binds to ESR2 protein] | affects binding|increases activity | 16076518 |
| C440975 | silybin | silybin results in increased activity of [ESR1 protein binds to ESR2 protein] | affects binding|increases activity | 16076518 |
| D012838 | Silymarin | Silymarin results in increased activity of [ESR1 protein binds to ESR2 protein] | affects binding|increases activity | 16076518 |
| D012838 | Silymarin | Silymarin results in increased activity of [ESR1 protein binds to ESR2 protein] | affects binding|increases activity | 16076518 |
| D012839 | Simazine | Simazine binds to ESR1 protein | affects binding | 8858116 |
| D012839 | Simazine | Simazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 8858116 |
| C025473 | sitosterol | sitosterol binds to ESR1 protein | affects binding | 11518614 |
| C017947 | sodium arsenite | sodium arsenite results in decreased expression of ESR1 mRNA | decreases expression | 17283378 |
| C017947 | sodium arsenite | [Diethylstilbestrol co-treated with sodium arsenite] results in increased expression of ESR1 protein | affects cotreatment|increases expression | 16452187 |
| C017947 | sodium arsenite | [sodium arsenite co-treated with Diethylstilbestrol] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 19665456 |
| C017947 | sodium arsenite | [sodium arsenite co-treated with Diethylstilbestrol] results in increased expression of ESR1 protein | affects cotreatment|increases expression | 16712894 |
| C017947 | sodium arsenite | [sodium arsenite co-treated with Tamoxifen] results in increased expression of ESR1 protein | affects cotreatment|increases expression | 16712894 |
| C017947 | sodium arsenite | [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 16368122 |
| C017947 | sodium arsenite | [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ESR1 protein | affects cotreatment|increases expression | 16368122 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of ESR1 mRNA | increases expression | 16452187 14691202 17077188 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of ESR1 protein | increases expression | 17077188 16507464 |
| D013228 | Stearates | Stearates results in increased activity of ESR1 protein | increases activity | 16756374 |
| C025462 | sulindac sulfide | sulindac sulfide results in decreased expression of ESR1 mRNA | decreases expression | 16740773 |
| C025462 | sulindac sulfide | sulindac sulfide results in decreased expression of ESR1 protein | decreases expression | 16740773 |
| C025463 | sulindac sulfone | sulindac sulfone results in decreased expression of ESR1 mRNA | decreases expression | 16740773 |
| C025463 | sulindac sulfone | sulindac sulfone results in decreased expression of ESR1 protein | decreases expression | 16740773 |
| C446685 | systhane | systhane binds to ESR1 protein | affects binding | 15253041 |
| D015085 | 2,4,5-Trichlorophenoxyacetic Acid | 2,4,5-Trichlorophenoxyacetic Acid binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 16626760 |
| D014284 | Triiodothyronine | Tamoxifen inhibits the reaction [Triiodothyronine results in decreased expression of ESR1 mRNA] | decreases expression|decreases reaction | 19942988 |
| D014284 | Triiodothyronine | Triiodothyronine results in decreased expression of ESR1 mRNA | decreases expression | 19942988 |
| C028226 | taleranol | taleranol results in increased activity of ESR1 protein | increases activity | 11331656 |
| C028226 | taleranol | taleranol results in increased activity of ESR1 protein | increases activity | 11331656 |
| D013629 | Tamoxifen | Tamoxifen binds to ESR1 protein | affects binding | 11162928 |
| D013629 | Tamoxifen | Tamoxifen affects the expression of ESR1 mRNA | affects expression | 20044124 |
| D013629 | Tamoxifen | Tamoxifen binds to ESR1 protein | affects binding | 11162928 |
| D013629 | Tamoxifen | [beta-Naphthoflavone co-treated with Tamoxifen] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 19456386 |
| D013629 | Tamoxifen | [nonylphenol co-treated with Tamoxifen] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 19456386 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 19456386 |
| D013629 | Tamoxifen | 4-hydroxy-N-desmethyltamoxifen inhibits the reaction [[Tamoxifen co-treated with N-desmethyltamoxifen co-treated with 4-hydroxytamoxifen] results in increased stability of ESR1 protein] | affects cotreatment|decreases reaction|increases stability | 19244106 |
| D013629 | Tamoxifen | BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]] | affects binding|affects reaction|increases reaction | 18997820 |
| D013629 | Tamoxifen | BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOR2 protein]] | affects binding|affects reaction|increases reaction | 18997820 |
| D013629 | Tamoxifen | BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to PHB2 protein]] | affects binding|affects reaction|increases reaction | 18997820 |
| D013629 | Tamoxifen | [CARM1 protein binds to ESR1 protein] which affects the susceptibility to Tamoxifen | affects binding|affects response to substance | 20360387 |
| D013629 | Tamoxifen | CARM1 protein promotes the reaction [Tamoxifen results in increased activity of ESR1 protein] | increases activity|increases reaction | 20360387 |
| D013629 | Tamoxifen | ESR1 gene polymorphism results in decreased susceptibility to Tamoxifen | decreases response to substance | 19487384 |
| D013629 | Tamoxifen | ESR1 mRNA alternative form affects the susceptibility to Tamoxifen | affects response to substance | 19011961 |
| D013629 | Tamoxifen | ESR1 protein affects the reaction [GATA3 protein affects the susceptibility to Tamoxifen] | affects reaction|affects response to substance | 19084267 |
| D013629 | Tamoxifen | ESR1 protein affects the reaction [Tamoxifen results in decreased expression of CAP2 mRNA] | affects reaction|decreases expression | 14699072 |
| D013629 | Tamoxifen | ESR1 protein affects the reaction [Tamoxifen results in decreased expression of F2R mRNA] | affects reaction|decreases expression | 14699072 |
| D013629 | Tamoxifen | ESR1 protein affects the reaction [Tamoxifen results in decreased expression of LGR5 mRNA] | affects reaction|decreases expression | 14699072 |
| D013629 | Tamoxifen | ESR1 protein affects the reaction [Tamoxifen results in decreased expression of NEK7 mRNA] | affects reaction|decreases expression | 14699072 |
| D013629 | Tamoxifen | ESR1 protein affects the reaction [Tamoxifen results in increased expression of FLOT1 mRNA] | affects reaction|increases expression | 14699072 |
| D013629 | Tamoxifen | ESR1 protein affects the reaction [Tamoxifen results in increased expression of FOXO1 mRNA] | affects reaction|increases expression | 14699072 |
| D013629 | Tamoxifen | ESR1 protein affects the reaction [Tamoxifen results in increased expression of G0S2 mRNA] | affects reaction|increases expression | 14699072 |
| D013629 | Tamoxifen | ESR1 protein affects the reaction [Tamoxifen results in increased expression of KLRC3 mRNA] | affects reaction|increases expression | 14699072 17395694 |
| D013629 | Tamoxifen | ESR1 protein affects the susceptibility to Tamoxifen | affects response to substance | 19487384 20458558 |
| D013629 | Tamoxifen | ESR1 protein alternative form results in increased susceptibility to Tamoxifen | increases response to substance | 20302909 |
| D013629 | Tamoxifen | ESR1 protein inhibits the reaction [Tamoxifen results in decreased expression of FOXM1 mRNA] | decreases expression|decreases reaction | 20208560 |
| D013629 | Tamoxifen | ESR1 protein promotes the reaction [Tamoxifen results in decreased expression of FOXM1 protein] | decreases expression|increases reaction | 20208560 |
| D013629 | Tamoxifen | ESR1 protein promotes the reaction [Tamoxifen results in increased abundance of Lipids] | increases abundance|increases reaction | 20079722 |
| D013629 | Tamoxifen | ESR1 protein results in decreased susceptibility to Tamoxifen | decreases response to substance | 20556506 |
| D013629 | Tamoxifen | ESR1 protein results in increased susceptibility to Tamoxifen | increases response to substance | 20208560 |
| D013629 | Tamoxifen | [Estradiol co-treated with Tamoxifen co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA | affects cotreatment|increases expression | 19351862 |
| D013629 | Tamoxifen | [EZH2 protein results in decreased expression of ESR1 protein] which results in decreased susceptibility to Tamoxifen | decreases expression|decreases response to substance | 20306127 |
| D013629 | Tamoxifen | FKBPL protein inhibits the reaction [Tamoxifen results in increased phosphorylation of ESR1 protein] | decreases reaction|increases phosphorylation | 20103631 |
| D013629 | Tamoxifen | FOXA1 protein affects the reaction [Tamoxifen affects the activity of ESR1 protein] | affects activity|affects reaction | 21151129 |
| D013629 | Tamoxifen | FOXL2 protein inhibits the reaction [[Tamoxifen results in increased activity of ESR1 protein] which results in increased expression of COX2 mRNA] | decreases reaction|increases activity|increases expression | 19797124 |
| D013629 | Tamoxifen | FOXM1 protein affects the reaction [ESR1 protein results in increased susceptibility to Tamoxifen] | affects reaction|increases response to substance | 20208560 |
| D013629 | Tamoxifen | HDAC4 protein inhibits the reaction [Tamoxifen results in increased activity of ESR1 protein] | decreases reaction|increases activity | 16051668 |
| D013629 | Tamoxifen | [HER2 protein results in increased activity of ESR1 protein] which results in decreased susceptibility to Tamoxifen | decreases response to substance|increases activity | 20179226 |
| D013629 | Tamoxifen | methoxyacetic acid promotes the reaction [Tamoxifen results in increased activity of ESR1 protein] | increases activity|increases reaction | 15103026 |
| D013629 | Tamoxifen | [NCOA1 protein binds to ESR1 protein] which results in increased susceptibility to Tamoxifen | affects binding|increases response to substance | 20332105 |
| D013629 | Tamoxifen | NCOR2 protein inhibits the reaction [Tamoxifen results in increased activity of ESR1 protein] | decreases reaction|increases activity | 20406620 |
| D013629 | Tamoxifen | Plant Extracts promotes the reaction [Tamoxifen inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ESR1 mRNA]] | decreases reaction|increases expression|increases reaction | 20559769 |
| D013629 | Tamoxifen | [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of ESR1 protein | affects cotreatment|decreases expression | 18855134 |
| D013629 | Tamoxifen | Tamoxifen affects the activity of ESR1 protein | affects activity | 19339991 |
| D013629 | Tamoxifen | Tamoxifen affects the expression of ESR1 mRNA | affects expression | 20543978 |
| D013629 | Tamoxifen | Tamoxifen affects the methylation of ESR1 promoter | affects methylation | 20473856 |
| D013629 | Tamoxifen | Tamoxifen analog binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 20621492 |
| D013629 | Tamoxifen | Tamoxifen binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 20211987 20406620 20208560 |
| D013629 | Tamoxifen | Tamoxifen binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 19059307 12765246 20332105 11174852 |
| D013629 | Tamoxifen | [Tamoxifen binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA | affects binding|increases activity|increases expression | 11174852 |
| D013629 | Tamoxifen | Tamoxifen binds to ESR1 protein | affects binding | 11518614 11162928 15842231 15521089 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in decreased expression of ANKRD28 mRNA | affects cotreatment|decreases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in decreased expression of CSF2 mRNA | affects cotreatment|decreases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in decreased expression of EGFR mRNA | affects cotreatment|decreases expression | 19347870 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in decreased expression of EGFR protein | affects cotreatment|decreases expression | 19347870 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in decreased expression of ENC1 mRNA | affects cotreatment|decreases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in decreased expression of HAS2 mRNA | affects cotreatment|decreases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in decreased expression of KCNN4 mRNA | affects cotreatment|decreases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in decreased expression of LMCD1 mRNA | affects cotreatment|decreases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in decreased expression of NCRNA00312 mRNA | affects cotreatment|decreases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in decreased expression of NOV mRNA | affects cotreatment|decreases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in decreased expression of PLAU mRNA | affects cotreatment|decreases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in decreased expression of RGS16 mRNA | affects cotreatment|decreases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in decreased expression of SLN mRNA | affects cotreatment|decreases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in decreased expression of TGFBI mRNA | affects cotreatment|decreases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in decreased expression of TNFRSF11B mRNA | affects cotreatment|decreases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in decreased expression of TXNIP mRNA | affects cotreatment|decreases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of BGLAP mRNA | affects cotreatment|increases expression | 19347870 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of BSP mRNA | affects cotreatment|increases expression | 19347870 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of C6ORF32 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of CA12 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of CRISPLD2 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of EDNRA mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of EIF1 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of ENPP2 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of FHL2 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of G0S2 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of GOLSYN mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of GRK5 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of HEG1 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of HK1 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of IDH2 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of ISG20 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA | affects cotreatment|increases expression | 19351862 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of KCTD12 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of KLRC2 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of LPL mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of MSMB mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of NLRP3 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of NPR2 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of OSBPL3 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of PFKFB3 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of PTPRE mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of RASGRP1 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of RET mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of RGS4 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of RHOBTB3 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of SEMA3B mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of SGK1 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of TIPARP mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of TMOD1 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of TMPRSS3 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of ZNF395 mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with Estradiol] results in decreased expression of ESR1 mRNA | affects cotreatment|decreases expression | 19434490 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with N-desmethyltamoxifen co-treated with 4-hydroxytamoxifen] results in increased stability of ESR1 protein | affects cotreatment|increases stability | 19244106 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [[bisphenol A affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]] | affects activity|decreases reaction|increases activity|increases reaction | 14975756 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [bisphenol A results in increased activity of ESR1 protein] | decreases reaction|increases activity | 16328721 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [butylbenzyl phthalate binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 15840436 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [Coumestrol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 16328721 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [Dibutyl Phthalate binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 15840436 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [dicyclohexyl phthalate binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 15840436 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [Diethylhexyl Phthalate binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 15840436 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [diisobutyl phthalate binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 15840436 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [di-n-hexyl phthalate binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 15840436 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [di-n-pentyl phthalate binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 15840436 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [[Endosulfan affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]] | affects activity|decreases reaction|increases activity|increases reaction | 14975756 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [ESR1 protein binds to CDKN1A promoter] | affects binding|decreases reaction | 20696891 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 12676605 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to AICDA promoter]] | affects binding|decreases reaction|increases reaction | 19139166 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to ESR1 protein]] | affects binding|decreases reaction|increases reaction | 15713566 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [Estradiol promotes the reaction [[ESR1 protein binds to FOXM1 promoter] which results in increased expression of FOXM1 mRNA]] | affects binding|decreases reaction|increases expression|increases reaction | 20208560 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA] | decreases expression|decreases reaction | 19942988 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 20061804 20204298 16328721 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 12377985 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [MEN1 protein binds to ESR1 protein] | affects binding|decreases reaction | 19847644 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [[Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]] | affects activity|decreases reaction|increases activity|increases reaction | 14975756 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [phthalic acid metabolite binds to and results in increased activity of ESR1 protein] | affects binding|decreases reaction|increases activity | 15840436 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]] | affects binding|decreases reaction|increases reaction | 17513867 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 20559769 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [Triiodothyronine results in decreased expression of ESR1 mRNA] | decreases expression|decreases reaction | 19942988 |
| D013629 | Tamoxifen | Tamoxifen metabolite binds to ESR1 protein | affects binding | 15135306 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [bisphenol A results in increased activity of ESR1 protein mutant form] | increases activity|increases reaction | 16328721 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [Coumestrol results in increased activity of ESR1 protein mutant form] | increases activity|increases reaction | 16328721 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [ESR1 protein binds to AGR2 promoter] | affects binding|increases reaction | 20531310 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [[ESR1 protein binds to AGR2 promoter] which results in increased expression of AGR2 mRNA] | affects binding|increases expression|increases reaction | 20531310 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [ESR1 protein binds to ESR1 protein] | affects binding|increases reaction | 20061804 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [ESR1 protein binds to ESR2 protein] | affects binding|increases reaction | 20061804 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [ESR1 protein binds to FOXL2 protein] | affects binding|increases reaction | 19797124 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [ESR1 protein binds to KLRC3 gene] | affects binding|increases reaction | 17395694 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [ESR1 protein binds to NCOR2 protein] | affects binding|increases reaction | 18997820 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [ESR1 protein binds to PGR promoter] | affects binding|increases reaction | 20406620 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [ESR1 protein binds to PHB2 protein] | affects binding|increases reaction | 18997820 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter] | affects binding|increases reaction | 20215421 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [[[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter] which results in increased expression of E2F1 mRNA] | affects binding|increases expression|increases reaction | 20215421 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [ESR1 protein binds to TFF1 promoter] | affects binding|increases reaction | 19858209 20406620 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [Estradiol results in increased activity of ESR1 protein mutant form] | increases activity|increases reaction | 16328721 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [SP1 protein binds to ESR1 protein] | affects binding|increases reaction | 20215421 |
| D013629 | Tamoxifen | Tamoxifen results in decreased activity of ESR1 protein | decreases activity | 20208560 |
| D013629 | Tamoxifen | Tamoxifen results in decreased expression of ESR1 mRNA | decreases expression | 20549698 |
| D013629 | Tamoxifen | Tamoxifen results in increased activity of ESR1 protein | increases activity | 17962382 15103026 20360387 20406620 |
| D013629 | Tamoxifen | [Tamoxifen results in increased activity of ESR1 protein] which results in increased expression of COX2 mRNA | increases activity|increases expression | 19797124 |
| D013629 | Tamoxifen | Tamoxifen results in increased expression of ESR1 mRNA | increases expression | 19432593 16010412 |
| D013629 | Tamoxifen | Tamoxifen results in increased expression of ESR1 protein | increases expression | 20549698 19244106 19435893 |
| D013629 | Tamoxifen | Tamoxifen results in increased phosphorylation of ESR1 protein | increases phosphorylation | 20103631 |
| D013629 | Tamoxifen | Tamoxifen results in increased stability of ESR1 protein | increases stability | 19477949 |
| D013629 | Tamoxifen | TP53 protein inhibits the reaction [Tamoxifen results in increased expression of ESR1 protein] | decreases reaction|increases expression | 20549698 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 9439733 |
| D013629 | Tamoxifen | Tamoxifen binds to ESR1 protein | affects binding | 15001543 |
| D013629 | Tamoxifen | [sodium arsenite co-treated with Tamoxifen] results in increased expression of ESR1 protein | affects cotreatment|increases expression | 16712894 |
| D013629 | Tamoxifen | Tamoxifen affects the expression of ESR1 mRNA | affects expression | 17555576 |
| D013629 | Tamoxifen | Tamoxifen binds to ESR1 protein | affects binding | 11162928 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [Estradiol results in increased expression of ESR1 protein] | increases expression|increases reaction | 19340542 |
| D013629 | Tamoxifen | Tamoxifen promotes the reaction [Linseed Oil results in decreased expression of ESR1 protein] | decreases expression|increases reaction | 21138602 |
| D013629 | Tamoxifen | [Estradiol co-treated with Tamoxifen] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 17823450 |
| D013629 | Tamoxifen | Tamoxifen binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 18348622 |
| D013629 | Tamoxifen | Tamoxifen binds to ESR1 protein | affects binding | 11162928 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]] | affects binding|decreases reaction|increases reaction | 19460436 |
| D013629 | Tamoxifen | Tamoxifen metabolite binds to ESR1 protein | affects binding | 16790557 |
| D013629 | Tamoxifen | Tamoxifen results in increased expression of ESR1 protein | increases expression | 11748029 |
| D013629 | Tamoxifen | Tamoxifen inhibits the reaction [4-nonylphenol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 17291011 |
| D013629 | Tamoxifen | Tamoxifen binds to ESR1 protein | affects binding | 19303142 |
| D013629 | Tamoxifen | Tamoxifen metabolite binds to ESR1 protein | affects binding | 16790557 |
| D013629 | Tamoxifen | Tamoxifen binds to ESR1 protein | affects binding | 16679488 16010412 |
| D013629 | Tamoxifen | Tamoxifen results in increased expression of ESR1 | increases expression | 19528477 |
| C401859 | temsirolimus | temsirolimus results in decreased activity of ESR1 protein | decreases activity | 16954435 |
| D013739 | Testosterone | [Testosterone co-treated with estradiol 3-benzoate] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 16023321 |
| D013739 | Testosterone | Testosterone binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 12676605 |
| D013739 | Testosterone | Testosterone results in decreased expression of ESR1 protein | decreases expression | 15916834 |
| D013739 | Testosterone | Testosterone binds to ESR1 protein | affects binding | 11944962 |
| D013739 | Testosterone | Testosterone results in increased expression of ESR1 mRNA | increases expression | 15917159 |
| D013739 | Testosterone | Testosterone binds to ESR1 protein | affects binding | 11944962 |
| C004648 | testosterone enanthate | testosterone enanthate results in increased activity of ESR1 protein | increases activity | 12504345 |
| C020806 | tetrabromobisphenol A | tetrabromobisphenol A binds to ESR1 protein | affects binding | 11693576 12753421 |
| C020806 | tetrabromobisphenol A | tetrabromobisphenol A results in decreased expression of ESR1 protein | decreases expression | 12505372 |
| C471350 | tetrabromobisphenol A-bisallylether | tetrabromobisphenol A-bisallylether results in decreased expression of ESR1 protein | decreases expression | 12505372 |
| C041181 | tetrachlorodian | tetrachlorodian binds to ESR1 protein | affects binding | 12753421 |
| D013749 | Tetrachlorodibenzodioxin | 4-hydroxytamoxifen inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]] | affects binding|decreases reaction|increases reaction | 19460354 |
| D013749 | Tetrachlorodibenzodioxin | 4-hydroxytamoxifen inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]] | affects binding|decreases reaction|increases reaction | 19460354 |
| D013749 | Tetrachlorodibenzodioxin | ESR1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] | increases expression|increases reaction | 19460354 |
| D013749 | Tetrachlorodibenzodioxin | ESR1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] | increases expression|increases reaction | 19460354 |
| D013749 | Tetrachlorodibenzodioxin | [Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [ESR1 protein binds to CYP1A1 enhancer] | affects binding|affects cotreatment|increases reaction | 15837795 |
| D013749 | Tetrachlorodibenzodioxin | Estradiol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CAD promoter]] | affects binding|decreases reaction|increases reaction | 16675542 |
| D013749 | Tetrachlorodibenzodioxin | Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]] | affects binding|increases reaction | 16675542 |
| D013749 | Tetrachlorodibenzodioxin | fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]] | affects binding|decreases reaction|increases reaction | 19460354 |
| D013749 | Tetrachlorodibenzodioxin | fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]] | affects binding|decreases reaction|increases reaction | 19460354 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of ESR1 protein | affects expression | 17960587 |
| D013749 | Tetrachlorodibenzodioxin | [Tetrachlorodibenzodioxin co-treated with Estradiol] promotes the reaction [ESR1 protein binds to CYP1A1 promoter] | affects binding|affects cotreatment|increases reaction | 15964790 |
| D013749 | Tetrachlorodibenzodioxin | [Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased activity of ESR1 protein | affects cotreatment|increases activity | 19578757 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin inhibits the reaction [ESR1 protein binds to ESR2 promoter] | affects binding|decreases reaction | 15207704 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 12021401 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to SP1 protein]] | affects binding|decreases reaction|increases reaction | 16675542 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in decreased expression of ESR1 protein] | decreases expression|decreases reaction | 19416221 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CAD promoter] | affects binding|increases reaction | 16675542 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter] | affects binding|increases reaction | 19460354 15964790 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter] | affects binding|increases reaction | 19460354 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of ESR1 mRNA | decreases expression | 12021401 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of ESR1 protein | decreases expression | 12021401 19578757 |
| D013749 | Tetrachlorodibenzodioxin | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 17942748 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased activity of ESR1 protein | decreases activity | 17991765 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of ESR1 mRNA | decreases expression | 19933214 |
| D013749 | Tetrachlorodibenzodioxin | CGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ESR1 protein] | decreases reaction|increases expression | 12128104 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of ESR1 mRNA | decreases expression | 16254025 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of ESR1 mRNA | increases expression | 11399792 17611358 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of ESR1 protein | increases expression | 12128104 11399792 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of ESR1 mRNA | decreases expression | 16431846 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of ESR1 protein | decreases expression | 16431846 |
| D013755 | Tetradecanoylphorbol Acetate | Plant Extracts inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 20559769 |
| D013755 | Tetradecanoylphorbol Acetate | Plant Extracts promotes the reaction [Tamoxifen inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ESR1 mRNA]] | decreases reaction|increases expression|increases reaction | 20559769 |
| D013755 | Tetradecanoylphorbol Acetate | Tamoxifen inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 20559769 |
| D013755 | Tetradecanoylphorbol Acetate | Tetradecanoylphorbol Acetate results in decreased expression of ESR1 protein | decreases expression | 10633228 |
| D013755 | Tetradecanoylphorbol Acetate | Tetradecanoylphorbol Acetate results in increased expression of ESR1 mRNA | increases expression | 20559769 |
| D013755 | Tetradecanoylphorbol Acetate | [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 16368122 |
| D013755 | Tetradecanoylphorbol Acetate | [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ESR1 protein | affects cotreatment|increases expression | 16368122 |
| D013755 | Tetradecanoylphorbol Acetate | Tetradecanoylphorbol Acetate promotes the reaction [Estradiol results in increased expression of ESR1 protein] | increases expression|increases reaction | 19340542 |
| C433164 | tetrahydrodaidzein | Estradiol affects the reaction [tetrahydrodaidzein affects the activity of ESR1 protein] | affects activity|affects reaction | 16965913 |
| C095210 | tetralin | tetralin analog results in decreased activity of ESR1 protein | decreases activity | 15737489 |
| C095210 | tetralin | tetralin analog results in increased activity of ESR1 protein | increases activity | 15737489 |
| C009424 | tetramethrin | tetramethrin results in decreased expression of ESR1 protein | decreases expression | 16326440 |
| C027385 | tibolone | tibolone metabolite results in increased activity of ESR1 protein | increases activity | 16720731 |
| C027385 | tibolone | tibolone results in increased activity of ESR1 protein | increases activity | 16720731 |
| C426783 | tolclofos-methyl | tolclofos-methyl results in increased activity of ESR1 protein | increases activity | 15064155 |
| D017312 | Toremifene | Toremifene inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 12079510 |
| D017312 | Toremifene | Toremifene inhibits the reaction [Estradiol results in increased expression of ESR1 protein] | decreases reaction|increases expression | 12079510 |
| D014112 | Toxaphene | [Toxaphene co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D014112 | Toxaphene | [Toxaphene co-treated with Dieldrin] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D014112 | Toxaphene | Toxaphene binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 10774817 11356845 16626760 |
| D014112 | Toxaphene | Toxaphene binds to ESR1 protein | affects binding | 14579009 |
| D014112 | Toxaphene | [Toxaphene co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D014112 | Toxaphene | [Toxaphene co-treated with Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|affects cotreatment|decreases reaction | 9168004 |
| D014112 | Toxaphene | Toxaphene inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| C411671 | TRAM 34 | TRAM 34 results in decreased expression of ESR1 mRNA | decreases expression | 20050851 |
| D014204 | Trenbolone | Trenbolone results in increased activity of ESR1 protein | increases activity | 11331656 |
| D014212 | Tretinoin | ESR1 protein promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein] | increases expression|increases reaction | 16730657 |
| D014212 | Tretinoin | Tretinoin results in increased expression of ESR1 protein | increases expression | 17387344 |
| D014212 | Tretinoin | Tretinoin affects the expression of ESR1 mRNA | affects expression | 11751013 |
| D014212 | Tretinoin | Tretinoin inhibits the reaction [Ethinyl Estradiol results in decreased expression of ESR1 mRNA] | decreases expression|decreases reaction | 17161848 |
| C036101 | tri-(2-ethylhexyl)trimellitate | tri-(2-ethylhexyl)trimellitate promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 16756374 |
| C036101 | tri-(2-ethylhexyl)trimellitate | tri-(2-ethylhexyl)trimellitate results in increased activity of ESR1 protein | increases activity | 16756374 |
| C032910 | triadimefon | triadimefon binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 10789375 |
| C032910 | triadimefon | triadimefon results in increased expression of ESR1 mRNA | increases expression | 19363144 |
| C032910 | triadimefon | triadimefon binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 9460653 |
| C011559 | tributyltin | tributyltin inhibits the reaction [Ethinyl Estradiol results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 16484284 |
| C012589 | trichostatin A | [decitabine co-treated with trichostatin A] affects the expression of ESR1 mRNA | affects cotreatment|affects expression | 18264725 |
| C012589 | trichostatin A | [decitabine co-treated with trichostatin A] promotes the reaction [TFAP2C protein binds to ESR1 promoter] | affects binding|affects cotreatment|increases reaction | 19458056 |
| C012589 | trichostatin A | [decitabine co-treated with trichostatin A] promotes the reaction [TFAP2C protein results in increased expression of ESR1 mRNA] | affects cotreatment|increases expression|increases reaction | 19458056 |
| C012589 | trichostatin A | [decitabine co-treated with trichostatin A] results in decreased expression of ESR1 mRNA | affects cotreatment|decreases expression | 17891453 |
| C012589 | trichostatin A | [decitabine co-treated with trichostatin A] results in decreased expression of ESR1 protein | affects cotreatment|decreases expression | 17891453 |
| C012589 | trichostatin A | [decitabine co-treated with trichostatin A] results in decreased stability of ESR1 mRNA | affects cotreatment|decreases stability | 17891453 |
| C012589 | trichostatin A | [decitabine co-treated with trichostatin A] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 17533736 19458056 |
| C012589 | trichostatin A | decitabine promotes the reaction [trichostatin A results in increased expression of ESR1 mRNA] | increases expression|increases reaction | 18092350 |
| C012589 | trichostatin A | TFAP2C protein promotes the reaction [[decitabine co-treated with trichostatin A] results in increased expression of ESR1 mRNA] | affects cotreatment|increases expression|increases reaction | 19458056 |
| C012589 | trichostatin A | [trichostatin A co-treated with TFAP2C protein] results in increased expression of ESR1 mRNA | affects cotreatment|increases expression | 19458056 |
| C012589 | trichostatin A | trichostatin A results in decreased expression of ESR1 mRNA | decreases expression | 17891453 |
| C012589 | trichostatin A | trichostatin A results in decreased expression of ESR1 protein | decreases expression | 17891453 |
| C012589 | trichostatin A | trichostatin A results in decreased stability of ESR1 mRNA | decreases stability | 17891453 |
| C012589 | trichostatin A | trichostatin A results in increased expression of ESR1 mRNA | increases expression | 18092350 |
| C012589 | trichostatin A | [estradiol dipropionate co-treated with trichostatin A] results in decreased expression of ESR1 protein | affects cotreatment|decreases expression | 15930180 |
| C009540 | triclocarban | triclocarban analog promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 18795164 |
| C009540 | triclocarban | triclocarban promotes the reaction [Estradiol results in increased activity of ESR1 protein] | increases activity|increases reaction | 18795164 |
| D014260 | Triclosan | Triclosan inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 17992702 |
| D014260 | Triclosan | Triclosan inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 18795164 |
| C020946 | triethylene glycol dimethacrylate | [Bisphenol A-Glycidyl Methacrylate co-treated with 2,2-di(4-methacryloxyphenyl)propane co-treated with triethylene glycol dimethacrylate] results in increased activity of ESR1 protein | affects cotreatment|increases activity | 11145352 |
| C482068 | TS 108 | TS 108 inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | decreases reaction|increases activity | 15671561 |
| C482068 | TS 108 | TS 108 binds to ESR1 protein | affects binding | 15671561 |
| C447031 | tyrphostin AG 1024 | tyrphostin AG 1024 inhibits the reaction [fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]] | affects binding|decreases reaction|increases reaction | 19815064 |
| C113580 | U 0126 | U 0126 promotes the reaction [NCOR2 protein binds to ESR1 protein] | affects binding|increases reaction | 20406620 |
| C113580 | U 0126 | [U 0126 promotes the reaction [NCOR2 protein binds to ESR1 protein]] which results in decreased activity of ESR1 protein | affects binding|decreases activity|increases reaction | 20406620 |
| C113580 | U 0126 | U 0126 results in increased expression of ESR1 mRNA | increases expression | 19088370 |
| C113580 | U 0126 | U 0126 results in increased expression of ESR1 protein | increases expression | 19088370 |
| D014635 | Valproic Acid | Valproic Acid results in increased expression of ESR1 mRNA | increases expression | 19772891 |
| D014635 | Valproic Acid | Valproic Acid results in increased expression of ESR1 protein | increases expression | 19772891 |
| C025643 | vinclozolin | vinclozolin binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 16626760 16750840 |
| C025643 | vinclozolin | vinclozolin binds to ESR1 protein | affects binding | 14579009 |
| C025643 | vinclozolin | vinclozolin inhibits the reaction [Estradiol binds to ESR1 protein] | affects binding|decreases reaction | 14579009 |
| C025643 | vinclozolin | vinclozolin results in decreased expression of ESR1 mRNA | decreases expression | 16504050 |
| C025643 | vinclozolin | vinclozolin results in increased expression of ESR1 mRNA | increases expression | 17980475 |
| C025643 | vinclozolin | vinclozolin results in increased expression of ESR1 mRNA alternative form | increases expression | 17980475 |
| C017963 | vinyl carbamate | vinyl carbamate results in decreased expression of ESR1 mRNA | decreases expression | 17849452 |
| D014801 | Vitamin A | Vitamin A inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA] | decreases reaction|increases expression | 19340624 |
| C518540 | Y134 compound | Y134 compound binds to and results in decreased activity of ESR1 protein | affects binding|decreases activity | 17115070 |
| C029659 | zearalenol | zearalenol binds to ESR1 protein | affects binding | 11162928 |
| C029659 | zearalenol | zearalenol binds to ESR1 protein | affects binding | 11162928 |
| C029659 | zearalenol | zearalenol binds to and results in increased activity of ESR1 protein | affects binding|increases activity | 15026083 |
| C029659 | zearalenol | zearalenol binds to ESR1 protein | affects binding | 11162928 |
| C029659 | zearalenol | zearalenol results in increased activity of ESR1 protein | increases activity | 11331656 |
| C029659 | zearalenol | zearalenol binds to ESR1 protein | affects binding | 11162928 |
| C029659 | zearalenol | zearalenol binds to ESR1 protein | affects binding | 11162928 |
| C029659 | zearalenol | zearalenol results in increased activity of ESR1 protein | increases activity | 11331656 |
| D015029 | Zeranol | Zeranol results in increased activity of ESR1 protein | increases activity | 11331656 |
| D015029 | Zeranol | Zeranol results in increased activity of ESR1 protein | increases activity | 11331656 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000008 | Abdominal Neoplasms | Tamoxifen | 2.94 | 14745880 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Carbamazepine | 20.09 | 8986270 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Diethylhexyl Phthalate | 20.09 | 6734493 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Ethanol | 20.09 | 17676605 18926900 | |
| MESH:D000014 | Abnormalities, Drug-Induced | methoxyacetic acid | 20.09 | 15959878 1761407 1761404 12805644 3652986 | |
| MESH:D000014 | Abnormalities, Drug-Induced | methyl cellosolve | 20.09 | 6474471 6499812 3652986 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Phenytoin | 20.09 | 6195326 10563481 9118846 9677735 8986270 3425630 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Tetrachlorodibenzodioxin | 20.09 | 15322242 14514962 11752688 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Valproic Acid | 20.09 | 8875741 | |
| MESH:D000015 | Abnormalities, Multiple | Valproic Acid | 5.48 | 19490988 | |
| MESH:D000015 | Abnormalities, Multiple | Vitamin A | 5.48 | 10992263 | |
| MESH:D000038 | Abscess | Drugs, Chinese Herbal | 4.69 | 15043669 | |
| MESH:D000052 | Acanthosis Nigricans | diethyl phthalate | 5.81 | 12616302 | |
| MESH:D000138 | Acidosis | Ethanol | 2.95 | 11192467 | |
| MESH:D000152 | Acne Vulgaris | Ethinyl Estradiol | 2.35 | 17505938 | |
| MESH:D000168 | Acrocephalosyndactylia | U 0126 | 3.92 | 17694057 | |
| MESH:D058186 | Acute Kidney Injury | resveratrol | 2.47 | 16538975 | |
| MESH:D055371 | Acute Lung Injury | Lipopolysaccharides | 6.82 | 11850527 18653653 | |
| MESH:D055371 | Acute Lung Injury | Oxygen | 6.82 | 16759491 | |
| MESH:D055371 | Acute Lung Injury | pirinixic acid | 6.82 | 18653653 | |
| MESH:D000230 | Adenocarcinoma | marker/mechanism | 15639718 20458558 | ||
| MESH:D000230 | Adenocarcinoma | 9,10-Dimethyl-1,2-benzanthracene | 14.84 | 12844480 10697514 | |
| MESH:D000230 | Adenocarcinoma | arsenic trioxide | 14.84 | 11798837 19825857 | |
| MESH:D000230 | Adenocarcinoma | Benzo(a)pyrene | 14.84 | 20464547 20127859 | |
| MESH:D000230 | Adenocarcinoma | daidzein | 14.84 | 11473722 | |
| MESH:D000230 | Adenocarcinoma | Doxorubicin | 14.84 | 17418594 | |
| MESH:D000230 | Adenocarcinoma | Estradiol | 14.84 | 11473722 | |
| MESH:D000230 | Adenocarcinoma | Ethinyl Estradiol | 14.84 | 14692618 | |
| MESH:D000230 | Adenocarcinoma | Genistein | 14.84 | 11473722 | |
| MESH:D000230 | Adenocarcinoma | Methylnitrosourea | 14.84 | 15113128 15688392 | |
| MESH:D000230 | Adenocarcinoma | vinyl carbamate | 14.84 | 16247444 17363558 | |
| MESH:D000236 | Adenoma | 4-dichlorobenzene | 13.72 | 12748734 | |
| MESH:D000236 | Adenoma | 9,10-Dimethyl-1,2-benzanthracene | 13.72 | 11376689 | |
| MESH:D000236 | Adenoma | Benzo(a)pyrene | 13.72 | 6695378 | |
| MESH:D000236 | Adenoma | beta-Naphthoflavone | 13.72 | 19389873 | |
| MESH:D000236 | Adenoma | Melatonin | 13.72 | 17195641 | |
| MESH:D000236 | Adenoma | Methylcholanthrene | 13.72 | 6695378 10545420 | |
| MESH:D000236 | Adenoma | resveratrol | 13.72 | 15688382 | |
| MESH:D018248 | Adenoma, Liver Cell | 3,4,5,3',4'-pentachlorobiphenyl | 20.91 | 16628245 | |
| MESH:D018248 | Adenoma, Liver Cell | DDT | 20.91 | 12597452 | |
| MESH:D018248 | Adenoma, Liver Cell | diethyl phthalate | 20.91 | 12616302 | |
| MESH:D018248 | Adenoma, Liver Cell | pirinixic acid | 20.91 | 16434500 | |
| MESH:D018248 | Adenoma, Liver Cell | Tetrachlorodibenzodioxin | 20.91 | 16835633 | |
| MESH:D018248 | Adenoma, Liver Cell | vinyl carbamate | 20.91 | 12371669 | |
| MESH:D011125 | Adenomatous Polyposis Coli | dibenzoylmethane | 6.01 | 17942926 | |
| MESH:D011125 | Adenomatous Polyposis Coli | sulindac sulfone | 6.01 | 16150858 | |
| MESH:D000310 | Adrenal Gland Neoplasms | Pentachlorophenol | 7.98 | 10696769 | |
| MESH:D000310 | Adrenal Gland Neoplasms | sodium arsenite | 7.98 | 15276417 | |
| MESH:D000309 | Adrenal Insufficiency | Dehydroepiandrosterone | 4.20 | 17302879 | |
| MESH:D018246 | Adrenocortical Adenoma | Arsenic | 8.47 | 17306315 | |
| MESH:D018246 | Adrenocortical Adenoma | sodium arsenite | 8.47 | 16712894 17306315 | |
| MESH:D000382 | Agricultural Workers' Diseases | alachlor | 31.07 | 11874814 14769641 | |
| MESH:D000382 | Agricultural Workers' Diseases | Atrazine | 31.07 | 11874814 | |
| MESH:D000382 | Agricultural Workers' Diseases | Chlorpyrifos | 31.07 | 17119214 16611668 11874814 | |
| MESH:D000382 | Agricultural Workers' Diseases | cypermethrin | 31.07 | 16487989 | |
| MESH:D000382 | Agricultural Workers' Diseases | DDT | 31.07 | 16487989 12584743 | |
| MESH:D000382 | Agricultural Workers' Diseases | Dichlorodiphenyl Dichloroethylene | 31.07 | 16487989 | |
| MESH:D000382 | Agricultural Workers' Diseases | Dicofol | 31.07 | 12584743 | |
| MESH:D000382 | Agricultural Workers' Diseases | Heptachlor | 31.07 | 12661182 | |
| MESH:D000382 | Agricultural Workers' Diseases | Lindane | 31.07 | 12661182 | |
| MESH:D000382 | Agricultural Workers' Diseases | Simazine | 31.07 | 12661182 | |
| MESH:D000382 | Agricultural Workers' Diseases | Toxaphene | 31.07 | 16132792 | |
| MESH:D000419 | Albuminuria | Doxorubicin | 6.37 | 21441931 | |
| MESH:D000419 | Albuminuria | Raloxifene | 6.37 | 17308373 17451421 | |
| MESH:D020268 | Alcohol-Induced Disorders, Nervous System | Ethanol | 3.71 | 15451039 15451040 | |
| MESH:D019973 | Alcohol-Related Disorders | Curcumin | 3.47 | 17887948 | |
| OMIM:607154 | ALLERGIC RHINITIS | Loratadine | 4.28 | 16527031 | |
| MESH:D000505 | Alopecia | Isoflavones | 4.98 | 17569567 | |
| MESH:D000505 | Alopecia | Tretinoin | 4.98 | 15955085 | |
| MESH:D000544 | Alzheimer Disease | marker/mechanism | 17192785 | ||
| MESH:D000544 | Alzheimer Disease | 24-hydroxycholesterol | 9.51 | 14523054 | |
| MESH:D000544 | Alzheimer Disease | 27-hydroxycholesterol | 9.51 | 20157255 14523054 | |
| MESH:D000544 | Alzheimer Disease | Curcumin | 9.51 | 15590663 | |
| MESH:D000544 | Alzheimer Disease | Goserelin | 9.51 | 16050439 | |
| MESH:D000544 | Alzheimer Disease | Plant Extracts | 9.51 | 16962711 | |
| MESH:D000544 | Alzheimer Disease | Raloxifene | 9.51 | 15800139 | |
| MESH:D000544 | Alzheimer Disease | resveratrol | 9.51 | 16162502 16183991 | |
| MESH:D000544 | Alzheimer Disease | sulindac sulfide | 9.51 | 18759972 | |
| MESH:D000550 | Amblyopia | Valproic Acid | 3.62 | 17688650 | |
| MESH:D000686 | Amyloidosis | Diethylstilbestrol | 2.96 | 15469931 | |
| MESH:D000740 | Anemia | Drugs, Chinese Herbal | 6.76 | 15504547 17963324 | |
| MESH:D000740 | Anemia | Tetrachlorodibenzodioxin | 6.76 | 11748828 | |
| MESH:D000740 | Anemia | Vitamin A | 6.76 | 16960172 | |
| MESH:D000743 | Anemia, Hemolytic | Quercetin | 2.78 | 17084956 | |
| MESH:D018798 | Anemia, Iron-Deficiency | Vitamin A | 3.36 | 16960172 | |
| MESH:D000748 | Anemia, Macrocytic | methyl cellosolve | 4.73 | 3699323 | |
| MESH:D000787 | Angina Pectoris | Drugs, Chinese Herbal | 3.83 | 11477813 | |
| MESH:D000799 | Angioedema | Acetaminophen | 2.25 | 10982225 | |
| MESH:D000853 | Anophthalmos | Benomyl | 7.25 | 15907663 | |
| MESH:D000853 | Anophthalmos | Ethanol | 7.25 | 15513904 | |
| MESH:D000860 | Anoxia | Oxygen | 3.49 | 20872349 | |
| MESH:D000987 | Antisocial Personality Disorder | Testosterone | 4.24 | 7506515 | |
| MESH:D001004 | Anus Diseases | Drugs, Chinese Herbal | 4.35 | 15043669 | |
| MESH:D001008 | Anxiety Disorders | Ethanol | 6.90 | 11141031 | |
| MESH:D001008 | Anxiety Disorders | Valproic Acid | 6.90 | 17497229 | |
| MESH:D001008 | Anxiety Disorders | vinclozolin | 6.90 | 19015723 | |
| MESH:D017544 | Aortic Aneurysm, Abdominal | Benzo(a)pyrene | 2.52 | 19183758 | |
| MESH:D001145 | Arrhythmias, Cardiac | Phenylephrine | 2.73 | 17460149 | |
| MESH:D020261 | Arsenic Poisoning | Arsenic | 2.21 | 16251483 12569548 18414634 16835338 | |
| MESH:D001161 | Arteriosclerosis | Cyclophosphamide | 8.48 | 15014928 | |
| MESH:D001161 | Arteriosclerosis | Ethinyl Estradiol | 8.48 | 11256880 | |
| MESH:D001161 | Arteriosclerosis | tibolone | 8.48 | 11256880 | |
| MESH:D001169 | Arthritis, Experimental | Dexamethasone | 10.14 | 17659584 | |
| MESH:D001169 | Arthritis, Experimental | Ethinyl Estradiol | 10.14 | 15885639 | |
| MESH:D001169 | Arthritis, Experimental | Plant Extracts | 10.14 | 14686799 | |
| MESH:D001169 | Arthritis, Experimental | resveratrol | 10.14 | 17115116 | |
| MESH:D001169 | Arthritis, Experimental | Tretinoin | 10.14 | 16412693 | |
| MESH:D015210 | Arthritis, Gouty | Drugs, Chinese Herbal | 4.16 | 19655406 | |
| MESH:D001172 | Arthritis, Rheumatoid | Curcumin | 3.45 | 16807698 | |
| MESH:D001172 | Arthritis, Rheumatoid | LY 117018 | 3.45 | 17907171 | |
| MESH:D001172 | Arthritis, Rheumatoid | Tretinoin | 3.45 | 16292516 | |
| MESH:D053627 | Asthenozoospermia | methyl cellosolve | 3.95 | 3987992 | |
| MESH:D001249 | Asthma | Loratadine | 3.42 | 9196086 | |
| MESH:D001249 | Asthma | Tretinoin | 3.42 | 16456186 | |
| MESH:D001249 | Asthma | Vitamin A | 3.42 | 16732791 | |
| MESH:D001260 | Ataxia Telangiectasia | Quercetin | 3.39 | 15336622 | |
| MESH:D050197 | Atherosclerosis | marker/mechanism | |||
| MESH:D050197 | Atherosclerosis | 27-hydroxycholesterol | 18.44 | 9059518 11166758 | |
| MESH:D050197 | Atherosclerosis | Arsenic | 18.44 | 19371607 12928151 | |
| MESH:D050197 | Atherosclerosis | Cadmium | 18.44 | 15687053 | |
| MESH:D050197 | Atherosclerosis | Curcumin | 18.44 | 18704882 | |
| MESH:D050197 | Atherosclerosis | Ethinyl Estradiol-Norgestrel Combination | 18.44 | 11996209 | |
| MESH:D050197 | Atherosclerosis | Methylcholanthrene | 18.44 | 11922910 | |
| MESH:D050197 | Atherosclerosis | Oxygen | 18.44 | 16391483 | |
| MESH:D050197 | Atherosclerosis | Phenytoin | 18.44 | 15136057 | |
| MESH:D050197 | Atherosclerosis | resveratrol | 18.44 | 16873680 17967414 | |
| MESH:D001284 | Atrophy | fulvestrant | 6.17 | 11514358 | |
| MESH:D001284 | Atrophy | methyl cellosolve | 6.17 | 3699323 2626667 6705890 | |
| MESH:D001289 | Attention Deficit Disorder with Hyperactivity | Oxidopamine | 4.71 | 14699433 | |
| MESH:D001289 | Attention Deficit Disorder with Hyperactivity | Phthalic Acids | 4.71 | 20106747 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 2.57 | 18445737 | |
| MESH:D001321 | Autistic Disorder | Melatonin | 2.57 | 16919138 16897403 | |
| MESH:D001321 | Autistic Disorder | Valproic Acid | 2.57 | 18177632 17507914 17688650 18940202 19232924 18985861 18775368 15238991 16609825 20603192 19460635 18558336 17157402 18396377 18316065 | |
| MESH:D001327 | Autoimmune Diseases | Curcumin | 5.73 | 19761891 | |
| MESH:D001327 | Autoimmune Diseases | Quercetin | 5.73 | 19761891 | |
| MESH:D001471 | Barrett Esophagus | Tretinoin | 2.86 | 16935849 | |
| MESH:D001607 | Berylliosis | Beryllium | 4.68 | 19589099 | |
| MESH:D001714 | Bipolar Disorder | Carbamazepine | 3.86 | 17594078 20046352 | |
| MESH:D001714 | Bipolar Disorder | Valproic Acid | 3.86 | 20046352 17594078 | |
| MESH:D001778 | Blood Coagulation Disorders | arsenic trioxide | 10.03 | 16206674 | |
| MESH:D001778 | Blood Coagulation Disorders | pirinixic acid | 10.03 | 19483382 | |
| MESH:D001778 | Blood Coagulation Disorders | Tetrachlorodibenzodioxin | 10.03 | 12125929 | |
| MESH:D001778 | Blood Coagulation Disorders | Tretinoin | 10.03 | 16206674 16197459 | |
| MESH:D001836 | Body Weight Changes | Tetrachlorodibenzodioxin | 2.19 | 15340226 | |
| MESH:D001848 | Bone Diseases, Developmental | Tetrachlorodibenzodioxin | 3.86 | 15746008 | |
| MESH:D001848 | Bone Diseases, Developmental | Valproic Acid | 3.86 | 8888407 | |
| MESH:D019046 | Bone Marrow Neoplasms | Doxorubicin | 3.10 | 14601052 | |
| MESH:D001859 | Bone Neoplasms | Paclitaxel | 3.08 | 15867366 | |
| MESH:D001862 | Bone Resorption | bisphenol A | 4.99 | 11985600 | |
| MESH:D001862 | Bone Resorption | Drugs, Chinese Herbal | 4.99 | 9881647 | |
| MESH:D001919 | Bradycardia | Phenylephrine | 3.00 | 15306635 | |
| MESH:D020201 | Brain Hemorrhage, Traumatic | Progesterone | 3.72 | 17868700 | |
| MESH:D001930 | Brain Injuries | Nitroprusside | 9.68 | 14637104 | |
| MESH:D001930 | Brain Injuries | Progesterone | 9.68 | 15665606 15845082 15380490 | |
| MESH:D001930 | Brain Injuries | Raloxifene | 9.68 | 16580743 | |
| MESH:D002545 | Brain Ischemia | beta Carotene | 11.62 | 16157235 | |
| MESH:D002545 | Brain Ischemia | Curcumin | 11.62 | 16770732 | |
| MESH:D002545 | Brain Ischemia | Plant Extracts | 11.62 | 16041641 | |
| MESH:D002545 | Brain Ischemia | resveratrol | 11.62 | 17600658 | |
| MESH:D001932 | Brain Neoplasms | Curcumin | 4.24 | 17596214 | |
| MESH:D001932 | Brain Neoplasms | Doxorubicin | 4.24 | 17150277 | |
| MESH:D001943 | Breast Neoplasms | marker/mechanism | 20104649 20421688 20458558 17417639 | ||
| MESH:D001943 | Breast Neoplasms | 2-(4-hydroxyphenyl)-3-methyl-1-(4-(2-piperidin-1-yl-ethoxy)-benzyl)-1H-indol-5-ol | 65.15 | 16954435 | |
| MESH:D001943 | Breast Neoplasms | 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide | 65.15 | 20861237 | |
| MESH:D001943 | Breast Neoplasms | 4-(1H-imidazol-1-yl)retinoic acid | 65.15 | 17387344 17145897 | |
| MESH:D001943 | Breast Neoplasms | 4-hydroxyestradiol-17 beta | 65.15 | 16675129 | |
| MESH:D001943 | Breast Neoplasms | 9,10-Dimethyl-1,2-benzanthracene | 65.15 | 18840765 16153821 20435547 15565634 17127718 | |
| MESH:D001943 | Breast Neoplasms | alitretinoin | 65.15 | 16344269 | |
| MESH:D001943 | Breast Neoplasms | Apigenin | 65.15 | 16541309 17132221 | |
| MESH:D001943 | Breast Neoplasms | Benzo(a)pyrene | 65.15 | 20146248 17474063 | |
| MESH:D001943 | Breast Neoplasms | beta-hexachlorocyclohexane | 65.15 | 17640349 12948864 | |
| MESH:D001943 | Breast Neoplasms | bexarotene | 65.15 | 16344269 16818667 | |
| MESH:D001943 | Breast Neoplasms | bisphenol A | 65.15 | 17123778 | |
| MESH:D001943 | Breast Neoplasms | Calcitriol | 65.15 | 11237771 | |
| MESH:D001943 | Breast Neoplasms | Curcumin | 65.15 | 16243823 19250217 18462866 18593918 | |
| MESH:D001943 | Breast Neoplasms | Cyclophosphamide | 65.15 | 12006526 18234424 17020986 18323546 15093573 11325840 15136595 17388661 16978400 | |
| MESH:D001943 | Breast Neoplasms | DDT | 65.15 | 12709520 16792888 | |
| MESH:D001943 | Breast Neoplasms | decitabine | 65.15 | 19208741 18320071 | |
| MESH:D001943 | Breast Neoplasms | Dichlorodiphenyl Dichloroethylene | 65.15 | 15061365 | |
| MESH:D001943 | Breast Neoplasms | Dieldrin | 65.15 | 15770527 11859874 | |
| MESH:D001943 | Breast Neoplasms | Diethylstilbestrol | 65.15 | 15324884 17129689 | |
| MESH:D001943 | Breast Neoplasms | Doxorubicin | 65.15 | 17983394 15993339 16935488 15692762 15634643 16826403 16322301 16096432 18382427 18628466 16115903 16264153 17369602 15939500 18234424 18695136 16595493 15136595 17426702 19526202 15994142 15668708 15567936 11325840 | |
| MESH:D001943 | Breast Neoplasms | EHT 1864 | 65.15 | 21118977 | |
| MESH:D001943 | Breast Neoplasms | equol | 65.15 | 16898868 | |
| MESH:D001943 | Breast Neoplasms | Estradiol | 65.15 | 17289903 19861407 12948864 18497071 16675129 14630087 17261762 17018787 | |
| MESH:D001943 | Breast Neoplasms | exemestane | 65.15 | 17952589 17892469 16002280 | |
| MESH:D001943 | Breast Neoplasms | fulvestrant | 65.15 | 18984771 | |
| MESH:D001943 | Breast Neoplasms | Genistein | 65.15 | 17200150 16873071 16541309 | |
| MESH:D001943 | Breast Neoplasms | Goserelin | 65.15 | 15668708 | |
| MESH:D001943 | Breast Neoplasms | GW 7604 | 65.15 | 17033922 | |
| MESH:D001943 | Breast Neoplasms | Heptachlor | 65.15 | 8738476 | |
| MESH:D001943 | Breast Neoplasms | Heptachlor Epoxide | 65.15 | 15770527 8738476 | |
| MESH:D001943 | Breast Neoplasms | indole-3-carbinol | 65.15 | 16082211 | |
| MESH:D001943 | Breast Neoplasms | kaempferol | 65.15 | 16756079 | |
| MESH:D001943 | Breast Neoplasms | lapatinib | 65.15 | 16091755 | |
| MESH:D001943 | Breast Neoplasms | letrozole | 65.15 | 16002280 17892469 | |
| MESH:D001943 | Breast Neoplasms | Lindane | 65.15 | 14688026 | |
| MESH:D001943 | Breast Neoplasms | Linseed Oil | 65.15 | 21138602 | |
| MESH:D001943 | Breast Neoplasms | LY 353381 | 65.15 | 19477949 | |
| MESH:D001943 | Breast Neoplasms | Methylcholanthrene | 65.15 | 17474063 | |
| MESH:D001943 | Breast Neoplasms | Methylnitrosourea | 65.15 | 14633655 11306469 16253758 | |
| MESH:D001943 | Breast Neoplasms | Oxygen | 65.15 | 17263869 | |
| MESH:D001943 | Breast Neoplasms | Paclitaxel | 65.15 | 16244791 15136595 16273361 16115903 18223236 18323546 18234424 11325840 | |
| MESH:D001943 | Breast Neoplasms | Phytoestrogens | 65.15 | 17176212 17158751 | |
| MESH:D001943 | Breast Neoplasms | Plant Preparations | 65.15 | 17398067 | |
| MESH:D001943 | Breast Neoplasms | Progesterone | 65.15 | 17614352 15562024 16175315 | |
| MESH:D001943 | Breast Neoplasms | Quercetin | 65.15 | 18628248 | |
| MESH:D001943 | Breast Neoplasms | Raloxifene | 65.15 | 17440819 16912660 17595753 15572757 15775269 17893378 17242785 15758505 17261762 17952589 16837676 17049068 | |
| MESH:D001943 | Breast Neoplasms | resveratrol | 65.15 | 17651959 17534123 16393696 | |
| MESH:D001943 | Breast Neoplasms | selenomethylselenocysteine | 65.15 | 18855134 | |
| MESH:D001943 | Breast Neoplasms | Tamoxifen | 65.15 | 18351453 20390343 20544844 17440819 19410462 17242785 19115204 18821012 19011961 18997820 19189210 17261762 19084267 21152245 16202921 19487384 19221464 16818667 18855134 19289846 15668708 19103187 20135344 21138602 17893378 18425577 19189212 19288272 15565566 20065188 18815881 19066611 19142967 17049068 16873071 20859285 19155303 18984771 16273361 19200415 11161223 20005174 19244106 18629630 19059307 | |
| MESH:D001943 | Breast Neoplasms | temsirolimus | 65.15 | 16954435 | |
| MESH:D001943 | Breast Neoplasms | Testosterone | 65.15 | 17261762 | |
| MESH:D001943 | Breast Neoplasms | Tetrachlorodibenzodioxin | 65.15 | 20435547 | |
| MESH:D001943 | Breast Neoplasms | Toremifene | 65.15 | 16273361 | |
| MESH:D001943 | Breast Neoplasms | Tretinoin | 65.15 | 16166294 16873071 16443354 | |
| MESH:D001997 | Bronchopulmonary Dysplasia | Tretinoin | 7.77 | 16813970 | |
| MESH:D001997 | Bronchopulmonary Dysplasia | Vitamin A | 7.77 | 17426644 17377406 | |
| MESH:D002051 | Burkitt Lymphoma | arsenic trioxide | 2.82 | 11589617 | |
| MESH:D002056 | Burns | Ethanol | 3.11 | 16374292 | |
| MESH:D002057 | Burns, Chemical | Plant Extracts | 3.73 | 9625245 | |
| MESH:D002105 | Cadmium Poisoning | Quercetin | 3.93 | 16962696 | |
| MESH:D002181 | Candidiasis, Vulvovaginal | Estradiol | 2.88 | 16111702 | |
| MESH:D002252 | Carbon Tetrachloride Poisoning | Carbon Tetrachloride | 5.35 | 18705752 16192424 16124888 16050911 16097048 15673190 10355542 15700767 3786805 16227642 16011737 15721981 | |
| MESH:D002252 | Carbon Tetrachloride Poisoning | Melatonin | 5.35 | 15700767 | |
| MESH:D002276 | Carcinoid Tumor | Doxorubicin | 3.21 | 16051944 | |
| MESH:D002277 | Carcinoma | 4-dichlorobenzene | 8.86 | 12748734 | |
| MESH:D002277 | Carcinoma | Curcumin | 8.86 | 18593918 | |
| MESH:D002277 | Carcinoma | Methylcholanthrene | 8.86 | 10545420 | |
| MESH:D002277 | Carcinoma | Tetrachlorodibenzodioxin | 8.86 | 16835633 | |
| MESH:D002280 | Carcinoma, Basal Cell | Arsenic | 2.46 | 15504454 17687452 | |
| MESH:D018270 | Carcinoma, Ductal, Breast | Tamoxifen | 2.94 | 19066611 | |
| MESH:D018236 | Carcinoma, Embryonal | Tretinoin | 3.54 | 16168501 | |
| MESH:D006528 | Carcinoma, Hepatocellular | marker/mechanism | 19363144 | ||
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 30.96 | 3084413 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Arsenic | 30.96 | 16507464 17306315 | |
| MESH:D006528 | Carcinoma, Hepatocellular | arsenic trioxide | 30.96 | 14691202 15553829 16217749 11135700 15073043 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Carbon Tetrachloride | 30.96 | 18788625 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Cyclophosphamide | 30.96 | 19701751 | |
| MESH:D006528 | Carcinoma, Hepatocellular | DDT | 30.96 | 12597452 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Diethylstilbestrol | 30.96 | 15948411 16924424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Doxorubicin | 30.96 | 17876044 18059187 16023760 16234567 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Estradiol | 30.96 | 16924424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Estrogens | 30.96 | 15341023 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Ethanol | 30.96 | 15763234 15289165 18788625 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Genistein | 30.96 | 16924424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | malachite green | 30.96 | 12616621 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Paclitaxel | 30.96 | 16313753 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Plant Extracts | 30.96 | 18834353 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Quercetin | 30.96 | 12508355 19519916 | |
| MESH:D006528 | Carcinoma, Hepatocellular | resveratrol | 30.96 | 16227395 19321006 | |
| MESH:D006528 | Carcinoma, Hepatocellular | sodium arsenite | 30.96 | 16507464 17306315 15276417 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Tamoxifen | 30.96 | 16924424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Tretinoin | 30.96 | 1917145 | |
| MESH:D006528 | Carcinoma, Hepatocellular | vinyl carbamate | 30.96 | 12371669 | |
| MESH:D002278 | Carcinoma in Situ | bisphenol A | 3.39 | 17123778 | |
| MESH:D018827 | Carcinoma, Lewis Lung | Cyclophosphamide | 6.27 | 16152834 | |
| MESH:D018827 | Carcinoma, Lewis Lung | resveratrol | 6.27 | 16675471 | |
| MESH:D002289 | Carcinoma, Non-Small-Cell Lung | bexarotene | 8.99 | 16247446 | |
| MESH:D002289 | Carcinoma, Non-Small-Cell Lung | Curcumin | 8.99 | 18414057 | |
| MESH:D002289 | Carcinoma, Non-Small-Cell Lung | gefitinib | 8.99 | 15496427 16230376 18347146 17290066 20005069 19233551 | |
| MESH:D002289 | Carcinoma, Non-Small-Cell Lung | sulindac sulfide | 8.99 | 12391285 | |
| MESH:D002289 | Carcinoma, Non-Small-Cell Lung | sulindac sulfone | 8.99 | 18758305 | |
| MESH:D002289 | Carcinoma, Non-Small-Cell Lung | vinyl carbamate | 8.99 | 16247446 | |
| MESH:D021441 | Carcinoma, Pancreatic Ductal | Quercetin | 3.39 | 17234771 | |
| MESH:D002291 | Carcinoma, Papillary | arsenic trioxide | 3.26 | 19014326 | |
| MESH:D002292 | Carcinoma, Renal Cell | Cyclophosphamide | 3.39 | 16201981 | |
| MESH:D002292 | Carcinoma, Renal Cell | Doxorubicin | 3.39 | 1485588 16201981 | |
| MESH:D018288 | Carcinoma, Small Cell | arsenic trioxide | 2.66 | 12490120 | |
| MESH:D002294 | Carcinoma, Squamous Cell | 9,10-Dimethyl-1,2-benzanthracene | 20.16 | 11376689 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Arsenic | 20.16 | 18922899 17687452 15504454 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Benzo(a)pyrene | 20.16 | 20419170 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Calcitriol | 20.16 | 11237771 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Curcumin | 20.16 | 18462866 | |
| MESH:D002294 | Carcinoma, Squamous Cell | decitabine | 20.16 | 19215824 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Doxorubicin | 20.16 | 6189445 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Plant Preparations | 20.16 | 17418620 | |
| MESH:D002294 | Carcinoma, Squamous Cell | resveratrol | 20.16 | 16227395 | |
| MESH:D002294 | Carcinoma, Squamous Cell | sodium arsenite | 20.16 | 18572023 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Tetradecanoylphorbol Acetate | 20.16 | 18922899 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Tretinoin | 20.16 | 16096774 16051514 | |
| MESH:D002295 | Carcinoma, Transitional Cell | Arsenic | 7.58 | 18640142 | |
| MESH:D002295 | Carcinoma, Transitional Cell | Raloxifene | 7.58 | 17572228 | |
| MESH:D002295 | Carcinoma, Transitional Cell | Tamoxifen | 7.58 | 17572228 | |
| MESH:D006332 | Cardiomegaly | Ethanol | 9.21 | 19332462 | |
| MESH:D006332 | Cardiomegaly | Phenylephrine | 9.21 | 16170337 11754973 17124262 11179087 15728586 17287366 | |
| MESH:D006332 | Cardiomegaly | Plant Extracts | 9.21 | 17645561 | |
| MESH:D006332 | Cardiomegaly | Quercetin | 9.21 | 19794523 | |
| MESH:D006332 | Cardiomegaly | Tetrachlorodibenzodioxin | 9.21 | 18670907 16120746 18850075 | |
| MESH:D009202 | Cardiomyopathies | Doxorubicin | 2.35 | 17924179 15505089 16455267 16731534 15792986 17382496 17928571 16651473 16242529 17974986 16952015 17351982 16278810 15476868 15811867 16269455 16364871 17519947 17329180 16109756 17007740 17308081 17131338 18627295 16612575 | |
| MESH:D002311 | Cardiomyopathy, Dilated | Doxorubicin | 2.18 | 17334414 16243910 | |
| MESH:D002318 | Cardiovascular Diseases | Arsenic | 24.24 | 15738583 19152805 17938729 | |
| MESH:D002318 | Cardiovascular Diseases | daidzein | 24.24 | 16332659 | |
| MESH:D002318 | Cardiovascular Diseases | Dioxins | 24.24 | 19057694 | |
| MESH:D002318 | Cardiovascular Diseases | Genistein | 24.24 | 16332659 | |
| MESH:D002318 | Cardiovascular Diseases | Isoflavones | 24.24 | 17689850 | |
| MESH:D002318 | Cardiovascular Diseases | kaempferol | 24.24 | 16756079 | |
| MESH:D002318 | Cardiovascular Diseases | Phytoestrogens | 24.24 | 16862667 | |
| MESH:D002318 | Cardiovascular Diseases | Plant Preparations | 24.24 | 16862667 | |
| MESH:D002318 | Cardiovascular Diseases | Raloxifene | 24.24 | 15775269 | |
| MESH:D002318 | Cardiovascular Diseases | resveratrol | 24.24 | 15458977 | |
| MESH:D002340 | Carotid Artery Diseases | Arsenic | 2.88 | 18022660 16973168 | |
| MESH:D016893 | Carotid Stenosis | Plant Preparations | 4.54 | 15158307 | |
| MESH:D002386 | Cataract | Acetaminophen | 5.49 | 10977129 | |
| MESH:D002386 | Cataract | Methylnitrosourea | 5.49 | 12484553 | |
| MESH:D002386 | Cataract | Tretinoin | 5.49 | 17460283 | |
| MESH:D002471 | Cell Transformation, Neoplastic | 4-hydroxyestradiol-17 beta | 10.13 | 18566989 18226522 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Cadmium | 10.13 | 17332340 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Estradiol | 10.13 | 18566989 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Methylcholanthrene | 10.13 | 16192471 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Methylnitrosourea | 10.13 | 7505956 2727394 | |
| MESH:D002471 | Cell Transformation, Neoplastic | sodium arsenite | 10.13 | 20056578 19524636 | |
| MESH:D002493 | Central Nervous System Diseases | Phenytoin | 3.75 | 4080065 | |
| MESH:D018290 | Cervical Intraepithelial Neoplasia | Tretinoin | 3.00 | 16129372 | |
| MESH:D002659 | Child Development Disorders, Pervasive | Testosterone | 3.23 | 20678186 | |
| MESH:D002659 | Child Development Disorders, Pervasive | Valproic Acid | 3.23 | 20734317 | |
| MESH:D015362 | Child Nutrition Disorders | Vitamin A | 3.87 | 16153327 | |
| MESH:D054506 | Chloracne | Dioxins | 4.07 | 18329192 | |
| MESH:D018281 | Cholangiocarcinoma | 3,4,5,3',4'-pentachlorobiphenyl | 5.07 | 16628245 | |
| MESH:D018281 | Cholangiocarcinoma | Tetrachlorodibenzodioxin | 5.07 | 16835633 | |
| MESH:D002764 | Cholecystitis | methyl cellosolve | 4.19 | 6499794 | |
| MESH:D002779 | Cholestasis | estradiol-17 beta-glucuronide | 8.54 | 12893835 | |
| MESH:D002779 | Cholestasis | Ethinyl Estradiol | 8.54 | 17333356 16105132 11677210 17681005 17110522 16919318 15861022 | |
| MESH:D002779 | Cholestasis | pirinixic acid | 8.54 | 19176532 | |
| MESH:D002779 | Cholestasis | Vitamin A | 8.54 | 16175620 | |
| OMIM:601042 | CHOREOATHETOSIS/SPASTICITY, EPISODIC | Phenytoin | 4.27 | 11748493 | |
| MESH:D002822 | Choriocarcinoma | Tretinoin | 3.54 | 16461808 | |
| MESH:D016770 | Ciliophora Infections | malachite green | 4.25 | 16175963 15900690 | |
| MESH:D002971 | Cleft Lip | Ethanol | 4.19 | 15513904 | |
| MESH:D002971 | Cleft Lip | Phenytoin | 4.19 | 2227380 | |
| MESH:D002972 | Cleft Palate | Ethanol | 15.20 | 15513904 | |
| MESH:D002972 | Cleft Palate | Hydrocortisone | 15.20 | 15826874 | |
| MESH:D002972 | Cleft Palate | Methanol | 15.20 | 8946559 | |
| MESH:D002972 | Cleft Palate | Phenytoin | 15.20 | 6862529 2227380 3877104 6856622 10789828 1687470 | |
| MESH:D002972 | Cleft Palate | Tetrachlorodibenzodioxin | 15.20 | 15668235 8697196 12621046 15340226 16354765 | |
| MESH:D002972 | Cleft Palate | Tretinoin | 15.20 | 9407595 | |
| MESH:D002972 | Cleft Palate | triadimefon | 15.20 | 16781842 | |
| MESH:D002972 | Cleft Palate | Vitamin A | 15.20 | 16054864 | |
| MESH:D003072 | Cognition Disorders | Raloxifene | 3.07 | 15800139 | |
| MESH:D003092 | Colitis | Curcumin | 7.27 | 16782535 18200517 16804969 | |
| MESH:D003092 | Colitis | resveratrol | 7.27 | 16474422 | |
| MESH:D003092 | Colitis | Tretinoin | 7.27 | 17035595 | |
| MESH:D003103 | Coloboma | Curcumin | 6.40 | 18809619 | |
| MESH:D003103 | Coloboma | Phenytoin | 6.40 | 9212184 | |
| MESH:D003110 | Colonic Neoplasms | arsenite | 10.14 | 15037631 | |
| MESH:D003110 | Colonic Neoplasms | Butyrates | 10.14 | 15936596 | |
| MESH:D003110 | Colonic Neoplasms | Curcumin | 10.14 | 16340194 19359593 | |
| MESH:D003110 | Colonic Neoplasms | decitabine | 10.14 | 17616700 | |
| MESH:D003110 | Colonic Neoplasms | Dexamethasone | 10.14 | 15824018 | |
| MESH:D003110 | Colonic Neoplasms | Genistein | 10.14 | 17182828 | |
| MESH:D003110 | Colonic Neoplasms | Quercetin | 10.14 | 17191121 11134977 19056647 16640504 15741050 19440933 17148506 | |
| MESH:D003110 | Colonic Neoplasms | resveratrol | 10.14 | 16338953 | |
| MESH:D003110 | Colonic Neoplasms | Vitamin A | 10.14 | 16267017 17219422 | |
| MESH:D015179 | Colorectal Neoplasms | arsenic trioxide | 7.26 | 20501625 | |
| MESH:D015179 | Colorectal Neoplasms | decitabine | 7.26 | 18981723 | |
| MESH:D015179 | Colorectal Neoplasms | Doxorubicin | 7.26 | 18802399 18259882 | |
| MESH:D015179 | Colorectal Neoplasms | gefitinib | 7.26 | 17594712 | |
| MESH:D015179 | Colorectal Neoplasms | Isoflavones | 7.26 | 17116718 | |
| MESH:D015179 | Colorectal Neoplasms | Paclitaxel | 7.26 | 18802399 | |
| MESH:D015179 | Colorectal Neoplasms | Polychlorinated Biphenyls | 7.26 | 15531428 | |
| MESH:D015179 | Colorectal Neoplasms | Quercetin | 7.26 | 18852136 18095365 | |
| MESH:D015179 | Colorectal Neoplasms | resveratrol | 7.26 | 16550006 | |
| MESH:D015179 | Colorectal Neoplasms | sulindac sulfone | 7.26 | 10666051 10416599 18059344 11197048 | |
| MESH:D000013 | Congenital Abnormalities | DDT | 18.05 | 15095906 | |
| MESH:D000013 | Congenital Abnormalities | Dichlorodiphenyldichloroethane | 18.05 | 15095906 | |
| MESH:D000013 | Congenital Abnormalities | methyl cellosolve | 18.05 | 6499821 12530607 | |
| MESH:D000013 | Congenital Abnormalities | Phenytoin | 18.05 | 10627286 | |
| MESH:D000013 | Congenital Abnormalities | Tetrachlorodibenzodioxin | 18.05 | 14669216 17141729 | |
| MESH:D000013 | Congenital Abnormalities | Triclosan | 18.05 | 19283420 | |
| MESH:D016510 | Corneal Neovascularization | Curcumin | 3.33 | 18497527 | |
| MESH:D003324 | Coronary Artery Disease | marker/mechanism | 20559769 | ||
| MESH:D003324 | Coronary Artery Disease | Plant Preparations | 3.19 | 15158307 | |
| MESH:D003327 | Coronary Disease | Phytoestrogens | 4.89 | 17367797 | |
| MESH:D003327 | Coronary Disease | resveratrol | 4.89 | 16507316 | |
| MESH:D023903 | Coronary Restenosis | arsenic trioxide | 2.66 | 12609071 | |
| MESH:D019465 | Craniofacial Abnormalities | 3,4,5,3',4'-pentachlorobiphenyl | 18.46 | 17686920 | |
| MESH:D019465 | Craniofacial Abnormalities | arsenic trioxide | 18.46 | 10525206 | |
| MESH:D019465 | Craniofacial Abnormalities | Carbamazepine | 18.46 | 9014606 | |
| MESH:D019465 | Craniofacial Abnormalities | decamethrin | 18.46 | 19861644 | |
| MESH:D019465 | Craniofacial Abnormalities | Dexamethasone | 18.46 | 17728286 | |
| MESH:D019465 | Craniofacial Abnormalities | Ethanol | 18.46 | 15513904 15451039 10194807 19302082 11873399 11198716 15451040 | |
| MESH:D019465 | Craniofacial Abnormalities | Hydrocortisone | 18.46 | 17728286 | |
| MESH:D019465 | Craniofacial Abnormalities | Methanol | 18.46 | 15108243 | |
| MESH:D019465 | Craniofacial Abnormalities | nitrofen | 18.46 | 11405365 | |
| MESH:D019465 | Craniofacial Abnormalities | Permethrin | 18.46 | 19861644 | |
| MESH:D019465 | Craniofacial Abnormalities | Phenytoin | 18.46 | 9212184 8986270 19952982 | |
| MESH:D019465 | Craniofacial Abnormalities | Tetrachlorodibenzodioxin | 18.46 | 10048152 15322242 20055451 | |
| MESH:D019465 | Craniofacial Abnormalities | Tretinoin | 18.46 | 16925845 9211117 10589399 9664655 17551590 8800419 14991402 9224671 9142499 9125849 | |
| MESH:D019465 | Craniofacial Abnormalities | triadimefon | 18.46 | 15834900 16875885 | |
| MESH:D019465 | Craniofacial Abnormalities | Valproic Acid | 18.46 | 16575769 8888407 17688650 | |
| MESH:D019465 | Craniofacial Abnormalities | Vitamin A | 18.46 | 10992263 | |
| MESH:D016638 | Critical Illness | Estrogens | 4.36 | 16670151 | |
| MESH:D003456 | Cryptorchidism | Dibutyl Phthalate | 10.55 | 16037377 | |
| MESH:D003456 | Cryptorchidism | Diethylstilbestrol | 10.55 | 12952375 16002989 | |
| MESH:D003456 | Cryptorchidism | vinclozolin | 10.55 | 14966744 | |
| MESH:D003490 | Cyanosis | Endosulfan | 4.00 | 7900959 | |
| MESH:D003556 | Cystitis | Cyclophosphamide | 3.39 | 12913760 16989017 12388444 10700343 15276878 17979934 16614059 18710439 18372110 18295254 18093676 12161096 16413132 16651033 11948286 17010015 15643279 18483878 18433785 10498854 | |
| MESH:D016757 | Death, Sudden, Cardiac | arsenic trioxide | 2.60 | 15213294 | |
| MESH:D003704 | Dementia | Polychlorinated Biphenyls | 3.25 | 16140633 | |
| MESH:D003711 | Demyelinating Diseases | Tamoxifen | 2.80 | 19031437 | |
| MESH:D003715 | Dengue | 24-hydroxycholesterol | 6.97 | 19427377 | |
| MESH:D003715 | Dengue | 27-hydroxycholesterol | 6.97 | 19427377 | |
| MESH:D003865 | Depressive Disorder, Major | Raloxifene | 2.75 | 17474826 | |
| MESH:D017449 | Dermatitis, Allergic Contact | alachlor | 3.94 | 8428444 | |
| MESH:D017449 | Dermatitis, Allergic Contact | Dexamethasone | 3.94 | 12438553 | |
| MESH:D017449 | Dermatitis, Allergic Contact | naphthenic acid | 3.94 | 16426290 | |
| MESH:D003876 | Dermatitis, Atopic | Diethylhexyl Phthalate | 3.47 | 16882537 | |
| MESH:D003876 | Dermatitis, Atopic | pirinixic acid | 3.47 | 18249437 | |
| MESH:D003877 | Dermatitis, Contact | bu-zhong-yi-qi-tang | 5.73 | 12188032 | |
| MESH:D003877 | Dermatitis, Contact | Permethrin | 5.73 | 14617103 | |
| MESH:D002658 | Developmental Disabilities | 2,3,3',4,4',5-hexachlorobiphenyl | 4.20 | 19647017 | |
| MESH:D003921 | Diabetes Mellitus, Experimental | Cyclophosphamide | 6.07 | 15331540 11751995 10990075 | |
| MESH:D003921 | Diabetes Mellitus, Experimental | Quercetin | 6.07 | 19496084 | |
| MESH:D003921 | Diabetes Mellitus, Experimental | resveratrol | 6.07 | 16873680 | |
| MESH:D003922 | Diabetes Mellitus, Type 1 | Cyclophosphamide | 4.19 | 18772604 | |
| MESH:D003922 | Diabetes Mellitus, Type 1 | Dehydroepiandrosterone | 4.19 | 16616286 | |
| MESH:D003922 | Diabetes Mellitus, Type 1 | Vitamin A | 4.19 | 16506275 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Curcumin | 3.99 | 18403477 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | daidzein | 3.99 | 16647724 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Genistein | 3.99 | 16647724 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Tetrachlorodibenzodioxin | 3.99 | 17107852 | |
| MESH:D003928 | Diabetic Nephropathies | Curcumin | 16.84 | 18204486 | |
| MESH:D003928 | Diabetic Nephropathies | Estradiol | 16.84 | 19279558 | |
| MESH:D003928 | Diabetic Nephropathies | Plant Extracts | 16.84 | 19706694 | |
| MESH:D003928 | Diabetic Nephropathies | Raloxifene | 16.84 | 17451421 15920148 17308373 | |
| MESH:D003928 | Diabetic Nephropathies | resveratrol | 16.84 | 16286809 | |
| MESH:D003928 | Diabetic Nephropathies | Tamoxifen | 16.84 | 19279558 | |
| MESH:D003929 | Diabetic Neuropathies | Progesterone | 2.94 | 17187935 | |
| MESH:D003967 | Diarrhea | Dexamethasone | 3.84 | 7237001 | |
| MESH:D003967 | Diarrhea | Hydrocortisone | 3.84 | 7237001 | |
| MESH:D018450 | Disease Progression | marker/mechanism | 20104649 | ||
| OMIM:607208 | DRAVET SYNDROME | Carbamazepine | 7.24 | 11748493 | |
| OMIM:607208 | DRAVET SYNDROME | Phenytoin | 7.24 | 11748493 | |
| MESH:D003875 | Drug Eruptions | Phenytoin | 3.94 | 15024534 | |
| MESH:D004342 | Drug Hypersensitivity | Carbamazepine | 3.23 | 16538176 20216337 16538175 15057820 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 12.52 | 12540782 2444490 11739529 14986274 11529661 12594235 16485898 11834606 16393943 19923254 10663392 16227642 17562736 19164858 19370779 19739265 19420014 16781746 18713872 16081117 10774834 19416960 11743745 11421492 15619225 12958197 14550746 18071297 12153990 14725611 12392966 15968718 17522070 19085960 17906064 11287661 10915739 16109766 12705907 16177239 11461765 | |
| MESH:D056486 | Drug-Induced Liver Injury | Carbamazepine | 12.52 | 17465707 | |
| MESH:D056486 | Drug-Induced Liver Injury | Carbon Tetrachloride | 12.52 | 7440962 10092053 15968718 15027814 16177239 11566570 2869522 3732212 16227642 7120509 4309450 6623471 17522070 15998439 9327722 3786805 19085960 19336974 6884620 10915739 21278145 7179309 | |
| MESH:D056486 | Drug-Induced Liver Injury | Doxorubicin | 12.52 | 17416283 | |
| MESH:D056486 | Drug-Induced Liver Injury | Drugs, Chinese Herbal | 12.52 | 15027814 | |
| MESH:D056486 | Drug-Induced Liver Injury | Ethanol | 12.52 | 11566570 | |
| MESH:D056486 | Drug-Induced Liver Injury | Ketoconazole | 12.52 | 18289764 | |
| MESH:D056486 | Drug-Induced Liver Injury | pyrazole | 12.52 | 12499123 | |
| MESH:D056486 | Drug-Induced Liver Injury | Silymarin | 12.52 | 14998559 | |
| MESH:D056486 | Drug-Induced Liver Injury | Tetrachlorodibenzodioxin | 12.52 | 20420201 | |
| MESH:D056486 | Drug-Induced Liver Injury | Valproic Acid | 12.52 | 1733752 19641884 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 2.49 | 19426721 | |
| MESH:D004362 | Drug Toxicity | Carbamazepine | 8.83 | 20216337 | |
| MESH:D004362 | Drug Toxicity | Doxorubicin | 8.83 | 18602426 | |
| MESH:D004362 | Drug Toxicity | Plant Preparations | 8.83 | 11033412 | |
| MESH:D004362 | Drug Toxicity | Tetrachlorodibenzodioxin | 8.83 | 11462148 | |
| MESH:D015352 | Dry Eye Syndromes | Vitamin A | 4.21 | 16146918 | |
| MESH:D004381 | Duodenal Ulcer | Curcumin | 2.60 | 17351913 | |
| MESH:D004417 | Dyspnea | cypermethrin | 15.51 | 16487989 | |
| MESH:D004417 | Dyspnea | DDT | 15.51 | 16487989 | |
| MESH:D004417 | Dyspnea | Dichlorodiphenyl Dichloroethylene | 15.51 | 16487989 | |
| MESH:D004417 | Dyspnea | Endosulfan | 15.51 | 7900959 3388749 | |
| MESH:D004417 | Dyspnea | Oxygen | 15.51 | 20016425 | |
| MESH:D004421 | Dystonia | Valproic Acid | 2.56 | 1851702 | |
| MESH:C538011 | Eales disease | Vitamin A | 4.01 | 9068938 | |
| MESH:D004480 | Ectromelia | Vitamin A | 4.21 | 16054864 | |
| MESH:D004485 | Eczema | Dexamethasone | 2.95 | 12438553 | |
| MESH:D004487 | Edema | bisindolylmaleimide I | 16.19 | 8273558 | |
| MESH:D004487 | Edema | Dexamethasone | 16.19 | 19703484 | |
| MESH:D004487 | Edema | perfluorooctanoic acid | 16.19 | 17259670 12083418 | |
| MESH:D004487 | Edema | pirinixic acid | 16.19 | 12083418 | |
| MESH:D004487 | Edema | Plant Extracts | 16.19 | 12787963 | |
| MESH:D004487 | Edema | Raloxifene | 16.19 | 15860553 | |
| MESH:D004487 | Edema | resveratrol | 16.19 | 8985016 | |
| MESH:D004487 | Edema | Tetrachlorodibenzodioxin | 16.19 | 12711302 11000095 | |
| MESH:D004487 | Edema | Tetradecanoylphorbol Acetate | 16.19 | 15177302 8273558 16716910 8113982 7812673 9599246 11698051 | |
| MESH:D004489 | Edema, Cardiac | 3,4,5,3',4'-pentachlorobiphenyl | 11.91 | 17686920 | |
| MESH:D004489 | Edema, Cardiac | Tetrachlorodibenzodioxin | 11.91 | 15322242 18230668 16714409 | |
| MESH:D004489 | Edema, Cardiac | Tretinoin | 11.91 | 18230668 | |
| MESH:D004646 | Emphysema | Endosulfan | 4.94 | 7900959 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | 24-hydroxycholesterol | 37.53 | 17410599 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | 27-hydroxycholesterol | 37.53 | 17410599 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Calcitriol | 37.53 | 15138306 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Carbamazepine | 37.53 | 17654737 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Ethinyl Estradiol | 37.53 | 12538720 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Phenytoin | 37.53 | 17654737 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Progesterone | 37.53 | 17692515 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | proteolipid protein 139-151 | 37.53 | 15845917 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Raloxifene | 37.53 | 15845917 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | resveratrol | 37.53 | 17872969 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Tamoxifen | 37.53 | 19031437 | |
| MESH:D004701 | Endocrine Gland Neoplasms | decitabine | 8.70 | 19294695 | |
| MESH:D004701 | Endocrine Gland Neoplasms | trichostatin A | 8.70 | 19294695 | |
| MESH:D018159 | Endolymphatic Hydrops | Dimethyl Sulfoxide | 4.94 | 20641076 | |
| MESH:D004714 | Endometrial Hyperplasia | Diethylstilbestrol | 16.44 | 16402032 | |
| MESH:D004714 | Endometrial Hyperplasia | Estriol | 16.44 | 16402032 | |
| MESH:D004714 | Endometrial Hyperplasia | Genistein | 16.44 | 16402032 | |
| MESH:D004714 | Endometrial Hyperplasia | Phytoestrogens | 16.44 | 16402032 | |
| MESH:D016889 | Endometrial Neoplasms | 4-hydroxytamoxifen | 26.26 | 19148513 | |
| MESH:D016889 | Endometrial Neoplasms | bu-zhong-yi-qi-tang | 26.26 | 17089059 | |
| MESH:D016889 | Endometrial Neoplasms | daidzein | 26.26 | 11473722 | |
| MESH:D016889 | Endometrial Neoplasms | Diethylstilbestrol | 26.26 | 15700306 16804899 | |
| MESH:D016889 | Endometrial Neoplasms | Doxorubicin | 26.26 | 17359293 | |
| MESH:D016889 | Endometrial Neoplasms | Estradiol | 26.26 | 18566989 11473722 19148513 | |
| MESH:D016889 | Endometrial Neoplasms | Genistein | 26.26 | 11473722 | |
| MESH:D016889 | Endometrial Neoplasms | Phytoestrogens | 26.26 | 16543667 | |
| MESH:D016889 | Endometrial Neoplasms | Tamoxifen | 26.26 | 19155303 20544844 17893378 16202921 | |
| MESH:D016889 | Endometrial Neoplasms | Tretinoin | 26.26 | 16569247 | |
| MESH:D004715 | Endometriosis | Mifepristone | 7.02 | 16134523 | |
| MESH:D004715 | Endometriosis | Progesterone | 7.02 | 16134523 | |
| MESH:D004715 | Endometriosis | Tetrachlorodibenzodioxin | 7.02 | 9294722 10568697 | |
| MESH:D004719 | Endomyocardial Fibrosis | Doxorubicin | 8.73 | 18037988 | |
| MESH:D004719 | Endomyocardial Fibrosis | Plant Extracts | 8.73 | 15268973 | |
| MESH:D019446 | Endotoxemia | dong quai | 6.08 | 16424112 | |
| MESH:D019446 | Endotoxemia | Lipopolysaccharides | 6.08 | 15328337 17637181 15821434 | |
| MESH:D020345 | Enterocolitis, Necrotizing | resveratrol | 3.29 | 17923197 | |
| MESH:D004802 | Eosinophilia | Cyclophosphamide | 2.77 | 11006010 | |
| MESH:D004816 | Epidermal Necrolysis, Toxic | Carbamazepine | 6.65 | 19915237 18855540 16415921 16538176 20485159 | |
| MESH:D004816 | Epidermal Necrolysis, Toxic | Phenytoin | 6.65 | 20235791 | |
| MESH:D004820 | Epidermolysis Bullosa | Phenytoin | 4.62 | 6251365 1399206 | |
| MESH:D004831 | Epilepsies, Myoclonic | Carbamazepine | 6.06 | 17275665 | |
| MESH:D004831 | Epilepsies, Myoclonic | Valproic Acid | 6.06 | 3659116 17275665 | |
| MESH:D004828 | Epilepsies, Partial | Carbamazepine | 8.02 | 16628512 17116037 15008574 | |
| MESH:D004828 | Epilepsies, Partial | Phenytoin | 8.02 | 11558140 17116037 | |
| MESH:D004828 | Epilepsies, Partial | Valproic Acid | 8.02 | 16628512 3922381 | |
| MESH:D004827 | Epilepsy | Carbamazepine | 6.67 | 17178248 9014606 18234410 19700373 7988514 19439326 821787 20417680 17465707 19620853 | |
| MESH:D004827 | Epilepsy | Phenytoin | 6.67 | 821787 11434505 20417680 | |
| MESH:D004827 | Epilepsy | Plant Extracts | 6.67 | 19700373 19439326 | |
| MESH:D004827 | Epilepsy | Valproic Acid | 6.67 | 18234410 20417680 | |
| MESH:D004832 | Epilepsy, Absence | Valproic Acid | 2.22 | 6254150 6426943 7562514 | |
| MESH:D017029 | Epilepsy, Complex Partial | Carbamazepine | 10.63 | 7750514 | |
| MESH:D017029 | Epilepsy, Complex Partial | Phenytoin | 10.63 | 7750514 | |
| MESH:D017029 | Epilepsy, Complex Partial | Valproic Acid | 10.63 | 7750514 | |
| MESH:D004830 | Epilepsy, Tonic-Clonic | Carbamazepine | 9.01 | 15276670 3659116 | |
| MESH:D004830 | Epilepsy, Tonic-Clonic | Phenytoin | 9.01 | 3659116 | |
| MESH:D004830 | Epilepsy, Tonic-Clonic | Valproic Acid | 9.01 | 3659116 | |
| MESH:D007172 | Erectile Dysfunction | daidzein | 6.00 | 14972507 | |
| MESH:D007172 | Erectile Dysfunction | estradiol valerate | 6.00 | 14972507 | |
| MESH:D004916 | Erythromelalgia | Carbamazepine | 4.13 | 19549232 | |
| MESH:D004938 | Esophageal Neoplasms | arsenic trioxide | 5.39 | 12903497 | |
| MESH:D004938 | Esophageal Neoplasms | Benzo(a)pyrene | 5.39 | 16530937 | |
| MESH:D004938 | Esophageal Neoplasms | Ethanol | 5.39 | 16704527 | |
| MESH:D004938 | Esophageal Neoplasms | Paclitaxel | 5.39 | 16481741 | |
| MESH:D004938 | Esophageal Neoplasms | Plant Preparations | 5.39 | 16510608 | |
| MESH:D005076 | Exanthema | Carbamazepine | 3.89 | 20485159 | |
| MESH:D005124 | Eye Abnormalities | Benomyl | 7.61 | 1914497 | |
| MESH:D005124 | Eye Abnormalities | Tetrachlorodibenzodioxin | 7.61 | 11564622 | |
| MESH:D005124 | Eye Abnormalities | Tretinoin | 7.61 | 9664655 16938888 | |
| MESH:D005234 | Fatty Liver | arsenic trioxide | 28.48 | 15073043 | |
| MESH:D005234 | Fatty Liver | arsenite | 28.48 | 18296743 | |
| MESH:D005234 | Fatty Liver | Carbon Tetrachloride | 28.48 | 15959796 16045604 16239168 61145 12631006 17595544 12795759 19224547 | |
| MESH:D005234 | Fatty Liver | Curcumin | 28.48 | 19297423 | |
| MESH:D005234 | Fatty Liver | Ethanol | 28.48 | 16409862 18620774 19236843 | |
| MESH:D005234 | Fatty Liver | Ethinyl Estradiol | 28.48 | 15345470 | |
| MESH:D005234 | Fatty Liver | pirinixic acid | 28.48 | 20131406 19236843 | |
| MESH:D005234 | Fatty Liver | Plant Extracts | 28.48 | 15975614 | |
| MESH:D005234 | Fatty Liver | Raloxifene | 28.48 | 17473493 | |
| MESH:D005234 | Fatty Liver | Tamoxifen | 28.48 | 19224547 14986274 | |
| MESH:D005234 | Fatty Liver | Valproic Acid | 28.48 | 14986274 19224547 | |
| MESH:D005235 | Fatty Liver, Alcoholic | Ethanol | 4.05 | 17920746 | |
| MESH:D052776 | Female Urogenital Diseases | marker/mechanism | 16002989 | ||
| MESH:D052776 | Female Urogenital Diseases | Diethylstilbestrol | 6.83 | 16513791 16611131 16534752 16002989 15751030 | |
| MESH:D052776 | Female Urogenital Diseases | Tamoxifen | 6.83 | 16709447 | |
| MESH:D052776 | Female Urogenital Diseases | Toremifene | 6.83 | 16709447 | |
| MESH:D005310 | Fetal Alcohol Syndrome | Ethanol | 3.71 | 15451040 16946407 15513904 10194807 | |
| MESH:D005313 | Fetal Death | Phenytoin | 5.61 | 10627286 | |
| MESH:D005313 | Fetal Death | Tetrachlorodibenzodioxin | 5.61 | 11858732 | |
| MESH:D005315 | Fetal Diseases | Valproic Acid | 3.27 | 16575769 | |
| MESH:D005317 | Fetal Growth Retardation | Valproic Acid | 2.61 | 18558336 8888407 | |
| MESH:D005327 | Fetal Resorption | methyl cellosolve | 7.24 | 6499812 6474471 3987992 6499821 | |
| MESH:D005327 | Fetal Resorption | Vitamin A | 7.24 | 16054864 | |
| MESH:D020567 | Fetal Weight | methyl cellosolve | 4.19 | 6474471 6499821 6499812 | |
| MESH:D005334 | Fever | Lipopolysaccharides | 2.62 | 11852909 9205823 | |
| MESH:D018221 | Fibromatosis, Abdominal | Tamoxifen | 2.94 | 14745880 | |
| MESH:D018222 | Fibromatosis, Aggressive | Doxorubicin | 6.21 | 19069698 | |
| MESH:D018222 | Fibromatosis, Aggressive | Tamoxifen | 6.21 | 19069698 | |
| MESH:D005354 | Fibrosarcoma | Methylcholanthrene | 6.98 | 14633661 10962813 | |
| MESH:D005354 | Fibrosarcoma | Methylnitrosourea | 6.98 | 11555667 | |
| MESH:D005355 | Fibrosis | arsenite | 18.58 | 18296743 | |
| MESH:D005355 | Fibrosis | Carbon Tetrachloride | 18.58 | 18705752 | |
| MESH:D005355 | Fibrosis | Curcumin | 18.58 | 18705752 | |
| MESH:D005355 | Fibrosis | Emodin | 18.58 | 19474275 | |
| MESH:D005355 | Fibrosis | Quercetin | 18.58 | 19474275 | |
| MESH:D005355 | Fibrosis | Tetrachlorodibenzodioxin | 18.58 | 20067830 | |
| MESH:D005355 | Fibrosis | Tretinoin | 18.58 | 17994277 | |
| MESH:D005391 | Firesetting Behavior | Testosterone | 4.24 | 7506515 | |
| MESH:D005393 | Fish Diseases | malachite green | 4.22 | 16175963 15900690 | |
| MESH:D005532 | Foot Deformities, Congenital | methoxyacetic acid | 7.39 | 3652986 | |
| MESH:D005532 | Foot Deformities, Congenital | methyl cellosolve | 7.39 | 3652986 | |
| MESH:D005534 | Foot Diseases | Arsenic | 3.94 | 6392382 | |
| MESH:D005706 | Gallbladder Neoplasms | arsenic trioxide | 2.73 | 16904648 | |
| MESH:D005739 | Gas Poisoning | Oxygen | 3.63 | 20016425 | |
| MESH:D005756 | Gastritis | Acetaminophen | 5.85 | 16983495 | |
| MESH:D005756 | Gastritis | Ethanol | 5.85 | 15046732 | |
| MESH:D005770 | Gastrointestinal Neoplasms | Captan | 7.17 | 8441825 | |
| MESH:D005770 | Gastrointestinal Neoplasms | Curcumin | 7.17 | 18462866 | |
| MESH:D030342 | Genetic Diseases, Inborn | vinclozolin | 3.34 | 16973722 | |
| MESH:D005832 | Genital Diseases, Male | vinclozolin | 3.68 | 16417039 | |
| MESH:D005833 | Genital Neoplasms, Female | Diethylstilbestrol | 7.56 | 16452187 | |
| MESH:D005833 | Genital Neoplasms, Female | sodium arsenite | 7.56 | 16452187 | |
| MESH:D005885 | Gingival Hyperplasia | Phenytoin | 4.08 | 9029455 | |
| MESH:D019214 | Gingival Overgrowth | Phenytoin | 4.62 | 16390469 14659971 | |
| MESH:D005909 | Glioblastoma | biochanin A | 20.67 | 16598420 | |
| MESH:D005909 | Glioblastoma | Curcumin | 20.67 | 17596214 | |
| MESH:D005909 | Glioblastoma | Doxorubicin | 20.67 | 17150277 | |
| MESH:D005909 | Glioblastoma | Genistein | 20.67 | 16598420 | |
| MESH:D005909 | Glioblastoma | Okadaic Acid | 20.67 | 17312396 | |
| MESH:D005909 | Glioblastoma | Quercetin | 20.67 | 19804834 | |
| MESH:D005909 | Glioblastoma | Testosterone | 20.67 | 17162496 | |
| MESH:D005909 | Glioblastoma | Tretinoin | 20.67 | 17312396 | |
| MESH:D005909 | Glioblastoma | trichostatin A | 20.67 | 18801729 | |
| MESH:D005910 | Glioma | Methylnitrosourea | 3.28 | 9825942 | |
| MESH:D005910 | Glioma | Quercetin | 3.28 | 17643826 | |
| MESH:D018316 | Gliosarcoma | Cyclophosphamide | 3.92 | 11389073 | |
| MESH:D006058 | Gonadal Disorders | Tetrachlorodibenzodioxin | 2.98 | 10696789 | |
| MESH:D006086 | Graft vs Host Disease | Cyclophosphamide | 3.48 | 16376943 11014644 15172196 | |
| MESH:D006099 | Granuloma | Beryllium | 5.90 | 19070257 | |
| MESH:D006177 | Gynecomastia | dong quai | 5.43 | 11405562 | |
| MESH:D006258 | Head and Neck Neoplasms | Curcumin | 8.05 | 18462866 18829502 | |
| MESH:D006258 | Head and Neck Neoplasms | decitabine | 8.05 | 19215824 | |
| MESH:D006258 | Head and Neck Neoplasms | Doxorubicin | 8.05 | 15692506 | |
| MESH:D006258 | Head and Neck Neoplasms | Tretinoin | 8.05 | 16096774 | |
| MESH:D034381 | Hearing Loss | Dimethyl Sulfoxide | 3.76 | 20641076 | |
| MESH:D006317 | Hearing Loss, Noise-Induced | Tretinoin | 3.54 | 16084493 | |
| MESH:D006330 | Heart Defects, Congenital | 3,4,3',4'-tetrachlorobiphenyl | 17.40 | 11294989 | |
| MESH:D006330 | Heart Defects, Congenital | 3,4,5,3',4'-pentachlorobiphenyl | 17.40 | 20471113 17686920 | |
| MESH:D006330 | Heart Defects, Congenital | Benzo(a)pyrene | 17.40 | 20471113 | |
| MESH:D006330 | Heart Defects, Congenital | nitrofen | 17.40 | 16080930 | |
| MESH:D006330 | Heart Defects, Congenital | polychlorodibenzo-4-dioxin | 17.40 | 11294989 | |
| MESH:D006330 | Heart Defects, Congenital | Tetrachlorodibenzodioxin | 17.40 | 11294989 10048152 | |
| MESH:D006330 | Heart Defects, Congenital | Tretinoin | 17.40 | 9664655 14991402 | |
| MESH:D006330 | Heart Defects, Congenital | Vitamin A | 17.40 | 10992263 16080930 | |
| MESH:D006331 | Heart Diseases | Doxorubicin | 3.65 | 17875725 18674790 16495754 16244371 18006777 17888722 16244372 16144979 16330681 14766674 12587719 16707910 16879835 | |
| MESH:D006331 | Heart Diseases | Raloxifene | 3.65 | 11110106 | |
| MESH:D006333 | Heart Failure | Doxorubicin | 4.92 | 17481944 | |
| MESH:D006333 | Heart Failure | pirinixic acid | 4.92 | 20558911 | |
| MESH:D006333 | Heart Failure | Plant Extracts | 4.92 | 18097624 | |
| MESH:D006345 | Heart Septal Defects, Ventricular | methyl cellosolve | 4.19 | 6499821 | |
| MESH:D006394 | Hemangiosarcoma | Doxorubicin | 4.83 | 15692506 | |
| MESH:D006394 | Hemangiosarcoma | Pentachlorophenol | 4.83 | 15200160 | |
| MESH:D006461 | Hemolysis | methyl cellosolve | 3.86 | 17874071 | |
| MESH:D006463 | Hemolytic-Uremic Syndrome | Lipopolysaccharides | 2.93 | 16366002 | |
| MESH:D006467 | Hemophilia A | Cyclophosphamide | 3.72 | 11918545 | |
| MESH:D006470 | Hemorrhage | Endosulfan | 5.54 | 7900959 | |
| MESH:D006470 | Hemorrhage | Tetrachlorodibenzodioxin | 5.54 | 11000095 | |
| MESH:D006504 | Hepatic Veno-Occlusive Disease | Cyclophosphamide | 3.92 | 14986274 | |
| MESH:D006505 | Hepatitis | Carbon Tetrachloride | 13.63 | 19900420 19110552 | |
| MESH:D006505 | Hepatitis | cypermethrin | 13.63 | 16487989 | |
| MESH:D006505 | Hepatitis | DDT | 13.63 | 16487989 | |
| MESH:D006505 | Hepatitis | Dichlorodiphenyl Dichloroethylene | 13.63 | 16487989 | |
| MESH:D006505 | Hepatitis | Drugs, Chinese Herbal | 13.63 | 18339527 | |
| MESH:D006529 | Hepatomegaly | chlorobenzilate | 36.95 | 2387028 | |
| MESH:D006529 | Hepatomegaly | DDT | 36.95 | 2387028 | |
| MESH:D006529 | Hepatomegaly | dichlorfop-methyl | 36.95 | 11275354 | |
| MESH:D006529 | Hepatomegaly | Dicofol | 36.95 | 2387028 | |
| MESH:D006529 | Hepatomegaly | fenarimol | 36.95 | 2387028 | |
| MESH:D006529 | Hepatomegaly | fenvalerate | 36.95 | 15602828 | |
| MESH:D006529 | Hepatomegaly | isopropyl 4,4'-dibromobenzilate | 36.95 | 2387028 | |
| MESH:D006529 | Hepatomegaly | perfluorooctanoic acid | 36.95 | 3609246 | |
| MESH:D006529 | Hepatomegaly | pirinixic acid | 36.95 | 16221962 18467677 19772884 19176532 | |
| MESH:D006529 | Hepatomegaly | systhane | 36.95 | 17178689 17178688 | |
| MESH:D006529 | Hepatomegaly | Tetrachlorodibenzodioxin | 36.95 | 15340226 16120746 12621046 | |
| MESH:D006529 | Hepatomegaly | triadimefon | 36.95 | 17178689 17178688 | |
| MESH:D015417 | Hereditary Sensory and Motor Neuropathy | Curcumin | 3.47 | 17701891 | |
| MESH:D006548 | Hernia, Diaphragmatic | Dexamethasone | 4.49 | 7520565 | |
| MESH:D006548 | Hernia, Diaphragmatic | nitrofen | 4.49 | 7520565 18280292 11409163 17618886 10898224 12746050 15764645 10541330 15578192 10370017 12904592 16473863 12759764 15756563 16863852 11588001 10359170 9473106 11584395 9575882 7576705 10898222 8863223 17270546 16490937 11051153 12194112 15707848 12505043 10646786 16720372 16292651 10370016 16080930 15136996 18280291 7760232 11685700 12407540 9476886 11057544 12547725 15185205 11329586 15088113 18958481 11076806 9859898 17245593 12021965 9698600 10693666 15793718 | |
| MESH:D006548 | Hernia, Diaphragmatic | Vitamin A | 4.49 | 16292552 15707848 17436238 16877224 16490937 16863852 | |
| MESH:D006558 | Herpes Genitalis | Estradiol | 3.41 | 15709030 | |
| MESH:D006561 | Herpes Simplex | Plant Extracts | 4.98 | 10715843 | |
| MESH:D006561 | Herpes Simplex | resveratrol | 4.98 | 16876885 | |
| MESH:D006628 | Hirsutism | Testosterone | 4.05 | 17019078 | |
| MESH:D015658 | HIV Infections | beta Carotene | 4.67 | 16960176 | |
| MESH:D015658 | HIV Infections | Plant Extracts | 4.67 | 12878215 | |
| MESH:D015658 | HIV Infections | Vitamin A | 4.67 | 16960176 | |
| MESH:D006679 | HIV Seropositivity | Vitamin A | 4.01 | 17209195 | |
| MESH:D019247 | HIV Wasting Syndrome | testosterone enanthate | 4.13 | 17440010 | |
| MESH:D006689 | Hodgkin Disease | Cyclophosphamide | 4.49 | 17606976 16135485 | |
| MESH:D006689 | Hodgkin Disease | Doxorubicin | 4.49 | 15147373 18501091 17606976 | |
| MESH:D006689 | Hodgkin Disease | sodium arsenite | 4.49 | 12676792 | |
| MESH:D019584 | Hot Flashes | 8-prenylnaringenin | 15.50 | 17088409 | |
| MESH:D019584 | Hot Flashes | dong quai | 15.50 | 18568789 | |
| MESH:D019584 | Hot Flashes | Estradiol | 15.50 | 17088409 | |
| MESH:D019584 | Hot Flashes | Isoflavones | 15.50 | 17290160 14716179 | |
| MESH:D019584 | Hot Flashes | Plant Extracts | 15.50 | 16566672 17454163 14716179 | |
| MESH:D006849 | Hydrocephalus | Valproic Acid | 3.27 | 17688650 | |
| MESH:D006869 | Hydronephrosis | Lithium Chloride | 7.71 | 19797860 | |
| MESH:D006869 | Hydronephrosis | Tetrachlorodibenzodioxin | 7.71 | 18606429 15340226 16959395 8697196 16354765 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 7.60 | 16870215 | |
| MESH:D006930 | Hyperalgesia | Ethanol | 7.60 | 18783367 | |
| MESH:D006930 | Hyperalgesia | perfluorooctanoic acid | 7.60 | 12083418 | |
| MESH:D006930 | Hyperalgesia | Tretinoin | 7.60 | 16870215 | |
| MESH:D017588 | Hyperandrogenism | Flutamide | 6.94 | 15356085 | |
| MESH:D017588 | Hyperandrogenism | Testosterone | 6.94 | 17019078 | |
| MESH:D006932 | Hyperbilirubinemia | Carbon Tetrachloride | 2.94 | 16899240 | |
| MESH:D006937 | Hypercholesterolemia | 27-hydroxycholesterol | 7.16 | 17873880 | |
| MESH:D006937 | Hypercholesterolemia | Curcumin | 7.16 | 18704882 | |
| MESH:D006937 | Hypercholesterolemia | resveratrol | 7.16 | 17188708 | |
| MESH:D017681 | Hypereosinophilic Syndrome | Tretinoin | 3.00 | 16778211 | |
| MESH:D006943 | Hyperglycemia | kaempferol | 7.47 | 18262572 | |
| MESH:D006943 | Hyperglycemia | pirinixic acid | 7.47 | 20558911 | |
| MESH:D006943 | Hyperglycemia | Quercetin | 7.47 | 11834736 18262572 | |
| MESH:D020138 | Hyperhomocysteinemia | Carbamazepine | 7.54 | 10459572 | |
| MESH:D020138 | Hyperhomocysteinemia | Phenytoin | 7.54 | 10459572 | |
| MESH:D020138 | Hyperhomocysteinemia | Plant Extracts | 7.54 | 16484555 | |
| MESH:D017488 | Hyperkeratosis, Epidermolytic | Arsenic | 3.00 | 17050553 | |
| MESH:D006949 | Hyperlipidemias | Plant Extracts | 4.71 | 15975614 15268973 | |
| MESH:D006949 | Hyperlipidemias | resveratrol | 4.71 | 16873680 | |
| MESH:D006965 | Hyperplasia | Carbamazepine | 6.16 | 18773962 | |
| MESH:D006965 | Hyperplasia | Diethylstilbestrol | 6.16 | 12960047 14722030 | |
| MESH:D006973 | Hypertension | Arsenic | 10.17 | 16076760 9931084 11953799 | |
| MESH:D006973 | Hypertension | daidzein | 10.17 | 17169123 | |
| MESH:D006973 | Hypertension | Dexamethasone | 10.17 | 17042910 | |
| MESH:D006973 | Hypertension | Phenylephrine | 10.17 | 8949925 12717712 | |
| MESH:D006973 | Hypertension | Quercetin | 10.17 | 18356687 | |
| MESH:D006973 | Hypertension | Raloxifene | 10.17 | 17577099 15787275 | |
| MESH:D006973 | Hypertension | Tetrachlorodibenzodioxin | 10.17 | 18850075 18670907 | |
| MESH:D006975 | Hypertension, Portal | Carbon Tetrachloride | 2.54 | 15338365 | |
| MESH:D046110 | Hypertension, Pregnancy-Induced | Hydralazine | 3.07 | 16612254 | |
| MESH:D006976 | Hypertension, Pulmonary | gefitinib | 3.46 | 18424623 | |
| MESH:D006984 | Hypertrophy | Phenylephrine | 3.08 | 12791704 18502941 | |
| MESH:D017379 | Hypertrophy, Left Ventricular | resveratrol | 2.86 | 17488730 | |
| MESH:D017380 | Hypertrophy, Right Ventricular | gefitinib | 4.64 | 18424623 | |
| MESH:D006986 | Hypervitaminosis A | Vitamin A | 4.55 | 16054864 | |
| MESH:D006987 | Hypesthesia | Arsenic | 3.94 | 16093927 | |
| MESH:D007006 | Hypogonadism | Testosterone | 3.30 | 12002444 | |
| MESH:D020514 | Hypokalemic Periodic Paralysis | Potassium | 4.28 | 19822448 | |
| MESH:D007018 | Hypopituitarism | Testosterone | 4.58 | 17426086 | |
| MESH:D007021 | Hypospadias | dichlorfop-methyl | 15.37 | 17035148 | |
| MESH:D007021 | Hypospadias | Diethylstilbestrol | 15.37 | 16002989 | |
| MESH:D007021 | Hypospadias | Ethinyl Estradiol | 15.37 | 16569931 16945680 | |
| MESH:D007021 | Hypospadias | Loratadine | 15.37 | 16407038 | |
| MESH:D007154 | Immune System Diseases | Cyclophosphamide | 3.72 | 16076520 | |
| MESH:D007174 | Impulse Control Disorders | Testosterone | 4.24 | 7506515 | |
| MESH:D020244 | Infarction, Middle Cerebral Artery | Progesterone | 6.33 | 15869954 | |
| MESH:D020244 | Infarction, Middle Cerebral Artery | resveratrol | 6.33 | 17600658 | |
| MESH:D007246 | Infertility | Diethylstilbestrol | 2.84 | 15036965 | |
| MESH:D007247 | Infertility, Female | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene | 12.42 | 12515675 | |
| MESH:D007247 | Infertility, Female | Dicofol | 12.42 | 10631594 11762692 | |
| MESH:D007247 | Infertility, Female | Dieldrin | 12.42 | 10630421 | |
| MESH:D007247 | Infertility, Female | Ethinyl Estradiol | 12.42 | 12013081 | |
| MESH:D007248 | Infertility, Male | 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene | 60.62 | 12515675 | |
| MESH:D007248 | Infertility, Male | alachlor | 60.62 | 16466525 12948887 17049205 | |
| MESH:D007248 | Infertility, Male | Atrazine | 60.62 | 12948887 | |
| MESH:D007248 | Infertility, Male | Chlordan | 60.62 | 9432128 | |
| MESH:D007248 | Infertility, Male | Clomiphene | 60.62 | 19371211 | |
| MESH:D007248 | Infertility, Male | Coumestrol | 60.62 | 16892005 | |
| MESH:D007248 | Infertility, Male | Cyclophosphamide | 60.62 | 7193160 16517039 | |
| MESH:D007248 | Infertility, Male | DDT | 60.62 | 17192596 17157474 | |
| MESH:D007248 | Infertility, Male | decitabine | 60.62 | 17581917 | |
| MESH:D007248 | Infertility, Male | Dichlorodiphenyl Dichloroethylene | 60.62 | 12948891 17192596 | |
| MESH:D007248 | Infertility, Male | Endosulfan | 60.62 | 8588293 9432128 | |
| MESH:D007248 | Infertility, Male | Ethinyl Estradiol | 60.62 | 17937319 | |
| MESH:D007248 | Infertility, Male | fulvestrant | 60.62 | 11514358 | |
| MESH:D007248 | Infertility, Male | Methoxychlor | 60.62 | 11955947 16467254 | |
| MESH:D007248 | Infertility, Male | methyl cellosolve | 60.62 | 3987992 | |
| MESH:D007248 | Infertility, Male | Methylnitrosourea | 60.62 | 7193160 | |
| MESH:D007248 | Infertility, Male | Phytoestrogens | 60.62 | 16731787 | |
| MESH:D007248 | Infertility, Male | pirimiphos methyl | 60.62 | 17604518 | |
| MESH:D007248 | Infertility, Male | sodium arsenite | 60.62 | 15346721 12646999 | |
| MESH:D007248 | Infertility, Male | Triclosan | 60.62 | 20821571 | |
| MESH:D007248 | Infertility, Male | vinclozolin | 60.62 | 16467254 | |
| MESH:D007249 | Inflammation | bisindolylmaleimide I | 22.57 | 8273558 | |
| MESH:D007249 | Inflammation | Curcumin | 22.57 | 16956363 18403477 17151092 | |
| MESH:D007249 | Inflammation | Dexamethasone | 22.57 | 8960868 11099482 | |
| MESH:D007249 | Inflammation | Flavonoids | 22.57 | 17296493 | |
| MESH:D007249 | Inflammation | Lipopolysaccharides | 22.57 | 17963957 17237260 17255318 12878042 9205823 | |
| MESH:D007249 | Inflammation | perfluorooctanoic acid | 22.57 | 12083418 | |
| MESH:D007249 | Inflammation | Plant Extracts | 22.57 | 15997105 12787963 19332304 16366677 | |
| MESH:D007249 | Inflammation | Progesterone | 22.57 | 15869954 | |
| MESH:D007249 | Inflammation | resveratrol | 22.57 | 16366677 | |
| MESH:D007249 | Inflammation | Silymarin | 22.57 | 17213517 | |
| MESH:D007249 | Inflammation | Tamoxifen | 22.57 | 19457130 | |
| MESH:D007249 | Inflammation | Tetrachlorodibenzodioxin | 22.57 | 12200463 12878042 | |
| MESH:D007249 | Inflammation | Tetradecanoylphorbol Acetate | 22.57 | 15177302 8273558 11698051 7812673 7562506 | |
| MESH:D007249 | Inflammation | Triclosan | 22.57 | 20507366 9584910 | |
| MESH:D015212 | Inflammatory Bowel Diseases | Curcumin | 2.34 | 18200517 18596194 | |
| MESH:D007251 | Influenza, Human | Quercetin | 5.92 | 16624496 | |
| MESH:D007251 | Influenza, Human | resveratrol | 5.92 | 16624496 | |
| MESH:D007299 | Insect Bites and Stings | cyhalothrin | 18.11 | 15189238 | |
| MESH:D007299 | Insect Bites and Stings | cypermethrin | 18.11 | 15189238 | |
| MESH:D007299 | Insect Bites and Stings | decamethrin | 18.11 | 15189238 | |
| MESH:D007299 | Insect Bites and Stings | Permethrin | 18.11 | 12749493 15189238 12971516 | |
| MESH:D007333 | Insulin Resistance | bisphenol A | 7.52 | 16393666 | |
| MESH:D007333 | Insulin Resistance | Estradiol | 7.52 | 16393666 16627594 | |
| MESH:D007333 | Insulin Resistance | pirinixic acid | 7.52 | 16306350 | |
| MESH:D007333 | Insulin Resistance | royal jelly | 7.52 | 18981581 | |
| MESH:D007410 | Intestinal Diseases | Tretinoin | 2.26 | 17994277 | |
| MESH:D007414 | Intestinal Neoplasms | Curcumin | 5.30 | 10783313 | |
| MESH:D007414 | Intestinal Neoplasms | Plant Extracts | 5.30 | 12584176 12628509 12351151 | |
| MESH:D019586 | Intracranial Hypertension | Vitamin A | 4.21 | 15955940 | |
| MESH:D019189 | Iron Metabolism Disorders | Lipopolysaccharides | 3.12 | 17255318 | |
| MESH:D007569 | Jaw Abnormalities | Ethanol | 12.65 | 15513904 | |
| MESH:D007569 | Jaw Abnormalities | Tetrachlorodibenzodioxin | 12.65 | 16580747 | |
| MESH:D007569 | Jaw Abnormalities | Tretinoin | 12.65 | 15992940 17551590 | |
| MESH:D007569 | Jaw Abnormalities | triadimefon | 12.65 | 15992940 15834900 | |
| MESH:D007627 | Keloid | Quercetin | 3.39 | 17086741 | |
| MESH:D007642 | Keratosis | Arsenic | 3.40 | 16930632 12749816 | |
| MESH:D017492 | Keratosis, Seborrheic | alitretinoin | 4.04 | 16144296 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 11.12 | 15629191 12587719 | |
| MESH:D007674 | Kidney Diseases | Cadmium | 11.12 | 16226777 16322080 16962696 | |
| MESH:D007674 | Kidney Diseases | Cadmium Chloride | 11.12 | 16962696 | |
| MESH:D007674 | Kidney Diseases | Doxorubicin | 11.12 | 16775033 15369732 15699352 | |
| MESH:D007674 | Kidney Diseases | Estradiol | 11.12 | 15618244 | |
| MESH:D007674 | Kidney Diseases | Quercetin | 11.12 | 16962696 | |
| MESH:D007674 | Kidney Diseases | sodium arsenite | 11.12 | 20008137 | |
| MESH:D007676 | Kidney Failure, Chronic | Doxorubicin | 2.70 | 16707910 | |
| MESH:D007680 | Kidney Neoplasms | 4-dichlorobenzene | 14.34 | 2471290 | |
| MESH:D007680 | Kidney Neoplasms | Captan | 14.34 | 8441825 | |
| MESH:D007680 | Kidney Neoplasms | Diethylstilbestrol | 14.34 | 16762066 15003126 14681315 | |
| MESH:D007680 | Kidney Neoplasms | Estradiol | 14.34 | 15610895 | |
| MESH:D007680 | Kidney Neoplasms | Estrone | 14.34 | 15610895 | |
| MESH:D007680 | Kidney Neoplasms | gefitinib | 14.34 | 18625569 | |
| MESH:D007680 | Kidney Neoplasms | Tamoxifen | 14.34 | 18625569 | |
| MESH:D007859 | Learning Disorders | DDT | 10.51 | 7589230 | |
| MESH:D007859 | Learning Disorders | Diethylstilbestrol | 10.51 | 17184923 | |
| MESH:D007859 | Learning Disorders | Endosulfan | 10.51 | 8157075 | |
| MESH:D007859 | Learning Disorders | Ethanol | 10.51 | 15451040 | |
| MESH:D007889 | Leiomyoma | marker/mechanism | 18701604 | ||
| MESH:D007889 | Leiomyoma | Curcumin | 10.24 | 18555241 | |
| MESH:D007889 | Leiomyoma | Goserelin | 10.24 | 16973256 | |
| MESH:D007889 | Leiomyoma | Raloxifene | 10.24 | 16973256 | |
| MESH:D007896 | Leishmaniasis | fenarimol | 4.06 | 18372651 | |
| MESH:D016773 | Leishmaniasis, Cutaneous | Ketoconazole | 3.38 | 2166429 19744259 8889330 1311351 | |
| MESH:D007898 | Leishmaniasis, Visceral | Ketoconazole | 3.31 | 11332679 | |
| MESH:D007938 | Leukemia | marker/mechanism | 18808365 | ||
| MESH:D007938 | Leukemia | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 24.57 | 12970779 | |
| MESH:D007938 | Leukemia | alachlor | 24.57 | 14769641 | |
| MESH:D007938 | Leukemia | arsenic trioxide | 24.57 | 15070760 | |
| MESH:D007938 | Leukemia | Curcumin | 24.57 | 18462866 | |
| MESH:D007938 | Leukemia | Cyclophosphamide | 24.57 | 10602166 | |
| MESH:D007938 | Leukemia | decitabine | 24.57 | 19235587 18980019 | |
| MESH:D007938 | Leukemia | Genistein | 24.57 | 18980019 17468513 | |
| MESH:D007938 | Leukemia | kaempferol | 24.57 | 17468513 | |
| MESH:D007938 | Leukemia | Permethrin | 24.57 | 12937054 | |
| MESH:D007938 | Leukemia | Quercetin | 24.57 | 17468513 | |
| MESH:D007938 | Leukemia | Tretinoin | 24.57 | 17143497 | |
| MESH:D004915 | Leukemia, Erythroblastic, Acute | Doxorubicin | 3.54 | 16085563 | |
| MESH:D015451 | Leukemia, Lymphocytic, Chronic, B-Cell | Cyclophosphamide | 3.71 | 17802794 18587576 17658394 17296974 18172266 17008537 | |
| MESH:D015451 | Leukemia, Lymphocytic, Chronic, B-Cell | Drugs, Chinese Herbal | 3.71 | 15802533 | |
| MESH:D007945 | Leukemia, Lymphoid | Toxaphene | 4.70 | 16132792 | |
| MESH:D015459 | Leukemia-Lymphoma, Adult T-Cell | arsenic trioxide | 7.93 | 17077332 12560223 | |
| MESH:D015459 | Leukemia-Lymphoma, Adult T-Cell | Curcumin | 7.93 | 16106398 | |
| MESH:D015459 | Leukemia-Lymphoma, Adult T-Cell | Emodin | 7.93 | 17077332 | |
| MESH:D007948 | Leukemia, Monocytic, Acute | arsenic trioxide | 10.61 | 16972261 | |
| MESH:D007948 | Leukemia, Monocytic, Acute | PD 98059 | 10.61 | 16972261 | |
| MESH:D007948 | Leukemia, Monocytic, Acute | U 0126 | 10.61 | 16972261 | |
| MESH:D015464 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | arsenic trioxide | 4.22 | 14633726 | |
| MESH:D015464 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | Cyclophosphamide | 4.22 | 10373061 | |
| MESH:D007951 | Leukemia, Myeloid | arsenic trioxide | 7.53 | 19077051 | |
| MESH:D007951 | Leukemia, Myeloid | decitabine | 7.53 | 17236224 19117987 18454857 | |
| MESH:D007951 | Leukemia, Myeloid | Tretinoin | 7.53 | 19285840 16482212 16932348 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | arsenic trioxide | 4.61 | 17050201 16467208 20471514 19850784 16968895 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | decitabine | 4.61 | 17679729 19387464 18704418 18206229 18460780 19010910 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | Tretinoin | 4.61 | 16294345 19850784 17596541 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | trichostatin A | 4.61 | 18206229 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | Valproic Acid | 4.61 | 16294345 17596541 | |
| MESH:D015477 | Leukemia, Myelomonocytic, Chronic | decitabine | 3.84 | 18055864 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | Arsenic | 7.91 | 17339181 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | arsenic trioxide | 7.91 | 11468182 16330433 16112521 11161223 16823087 15336539 17107899 12679006 17712046 19225113 9834237 16966277 16891316 19642359 19075265 15748426 12712474 19035177 15213294 12018890 17869043 16331271 15622746 17217047 17649720 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | resveratrol | 7.91 | 16087638 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | Tretinoin | 7.91 | 17294898 12679006 19075265 17506722 17649720 19225113 17361223 19029980 16823087 16140955 17712046 16935935 16788101 17301526 19642359 17368321 9834237 17217047 16891316 16331271 17339181 15748426 17107899 16766008 19035177 | |
| MESH:D015458 | Leukemia, T-Cell | arsenic trioxide | 6.62 | 16882451 | |
| MESH:D015458 | Leukemia, T-Cell | Curcumin | 6.62 | 16106398 | |
| MESH:D007970 | Leukopenia | Cyclophosphamide | 6.54 | 11830472 10052129 | |
| MESH:D007970 | Leukopenia | Lipopolysaccharides | 6.54 | 15821434 | |
| MESH:D007984 | Leydig Cell Tumor | perfluorooctanoic acid | 7.68 | 8812269 | |
| MESH:D007984 | Leydig Cell Tumor | vinclozolin | 7.68 | 16417039 | |
| MESH:D017880 | Limb Deformities, Congenital | Dichlorodiphenyl Dichloroethylene | 18.44 | 12745335 | |
| MESH:D017880 | Limb Deformities, Congenital | Ethanol | 18.44 | 17676605 | |
| MESH:D017880 | Limb Deformities, Congenital | methoxyacetic acid | 18.44 | 15959878 12805644 | |
| MESH:D017880 | Limb Deformities, Congenital | methyl cellosolve | 18.44 | 6499821 | |
| MESH:D017880 | Limb Deformities, Congenital | Methylnitrosourea | 18.44 | 15526292 | |
| MESH:D017880 | Limb Deformities, Congenital | Tretinoin | 18.44 | 9224671 | |
| MESH:D017880 | Limb Deformities, Congenital | Vitamin A | 18.44 | 16054864 | |
| MESH:D008064 | Lipidoses | Ketoconazole | 5.99 | 17567588 | |
| MESH:D008064 | Lipidoses | Loratadine | 5.99 | 17567588 | |
| MESH:D008064 | Lipidoses | Tamoxifen | 5.99 | 17567588 15342952 | |
| MESH:D008080 | Liposarcoma | Paclitaxel | 3.31 | 17353645 | |
| MESH:D008103 | Liver Cirrhosis | arsenite | 13.69 | 18296743 | |
| MESH:D008103 | Liver Cirrhosis | Carbon Tetrachloride | 13.69 | 16239168 11408273 21278145 16943688 17157831 17334410 16221502 17174718 11903743 | |
| MESH:D008103 | Liver Cirrhosis | Drugs, Chinese Herbal | 13.69 | 17163593 | |
| MESH:D008103 | Liver Cirrhosis | Ethanol | 13.69 | 15289165 | |
| MESH:D008103 | Liver Cirrhosis | Plant Extracts | 13.69 | 17157831 | |
| MESH:D008103 | Liver Cirrhosis | Silymarin | 13.69 | 17213517 | |
| MESH:D008103 | Liver Cirrhosis | Vitamin A | 13.69 | 16256175 | |
| MESH:D008104 | Liver Cirrhosis, Alcoholic | Ethanol | 3.51 | 18295389 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Carbon Tetrachloride | 28.64 | 17976157 17721639 18472332 15362042 16011737 16027843 12609069 18156304 18395095 18418968 18263696 18279442 14748882 17766677 15959796 12667390 18420326 18166357 18277467 10355542 16015684 12958196 14716833 12632512 15818738 15876570 15931870 17631135 17708605 17900296 17869086 16097048 12546737 20821823 15730626 12741479 14716496 16248980 18006644 11481614 17557913 17805973 17481882 15996030 14620537 18317297 12632514 12445421 17761835 17565644 15925388 18205269 18054572 15650968 17698563 15893842 17922224 15052691 18472094 14724832 12389079 18339082 16638106 18210741 12898905 13678700 12445418 18429990 16136751 17640975 12666154 18481824 15673190 18705752 17823541 16192424 14512876 15057751 15370692 16116963 17714472 17525996 18376398 18187930 12649538 12586293 18251166 18412020 18395914 17944888 15123356 16033810 15338365 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Curcumin | 28.64 | 17355460 18705752 18006644 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Dexamethasone | 28.64 | 16718785 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Dimethyl Sulfoxide | 28.64 | 11682029 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Doxorubicin | 28.64 | 16439617 16595196 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Drugs, Chinese Herbal | 28.64 | 18606216 18567088 15744066 18371158 15383259 15754396 16610055 12632512 17666798 17348192 17036385 17881167 15641146 15763062 18237412 15864749 17629604 15849816 15818738 15339415 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Emodin | 28.64 | 15288473 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Estradiol | 28.64 | 14716833 14659978 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Ethanol | 28.64 | 18166357 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Genistein | 28.64 | 17823541 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Lipopolysaccharides | 28.64 | 12878042 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Melatonin | 28.64 | 15298665 15925388 16703270 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | naringenin | 28.64 | 14709902 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | pirinixic acid | 28.64 | 15474484 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Plant Extracts | 28.64 | 15479170 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Plant Preparations | 28.64 | 17724770 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Quercetin | 28.64 | 12741479 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | silybin | 28.64 | 16169303 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Silymarin | 28.64 | 15754394 17198567 18277467 15864749 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Tamoxifen | 28.64 | 18564211 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Tetrachlorodibenzodioxin | 28.64 | 12878042 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Tretinoin | 28.64 | 16248980 18397230 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Vitamin A | 28.64 | 16248980 | |
| MESH:D008107 | Liver Diseases | 1,3-dichlorobenzene | 28.84 | 1853346 8661352 | |
| MESH:D008107 | Liver Diseases | 4-dichlorobenzene | 28.84 | 8661352 1715830 1949037 7801330 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 28.84 | 16610002 19014921 12969438 12587719 16611625 19460945 11587558 19784758 | |
| MESH:D008107 | Liver Diseases | Arsenic | 28.84 | 11134558 | |
| MESH:D008107 | Liver Diseases | Carbon Tetrachloride | 28.84 | 17285989 15830285 15720792 16246199 16964402 | |
| MESH:D008107 | Liver Diseases | Chlorpyrifos | 28.84 | 15991261 | |
| MESH:D008107 | Liver Diseases | Curcumin | 28.84 | 16956363 | |
| MESH:D008107 | Liver Diseases | cypermethrin | 28.84 | 15991261 | |
| MESH:D008107 | Liver Diseases | DDT | 28.84 | 15729006 | |
| MESH:D008107 | Liver Diseases | Drugs, Chinese Herbal | 28.84 | 17207593 | |
| MESH:D008107 | Liver Diseases | Lindane | 28.84 | 1715830 | |
| MESH:D008107 | Liver Diseases | naringenin | 28.84 | 16945181 | |
| MESH:D008107 | Liver Diseases | Phenytoin | 28.84 | 14986274 | |
| MESH:D008107 | Liver Diseases | Plant Extracts | 28.84 | 17034775 | |
| MESH:D008107 | Liver Diseases | Silymarin | 28.84 | 17213517 | |
| MESH:D008107 | Liver Diseases | triadimefon | 28.84 | 19363144 | |
| MESH:D008107 | Liver Diseases | Vitamin A | 28.84 | 16175620 | |
| MESH:D008108 | Liver Diseases, Alcoholic | Ethanol | 10.26 | 17347304 17207112 | |
| MESH:D008108 | Liver Diseases, Alcoholic | Silymarin | 10.26 | 17213517 | |
| MESH:D008108 | Liver Diseases, Alcoholic | Vitamin A | 10.26 | 16762690 | |
| MESH:D017093 | Liver Failure | Carbon Tetrachloride | 2.61 | 15123358 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 4.60 | 16871587 17185352 | |
| MESH:D017114 | Liver Failure, Acute | Carbon Tetrachloride | 4.60 | 14706259 16899240 | |
| MESH:D008113 | Liver Neoplasms | marker/mechanism | 16712894 | ||
| MESH:D008113 | Liver Neoplasms | 2,4,5,2',4',5'-hexachlorobiphenyl | 62.42 | 18644402 16835634 | |
| MESH:D008113 | Liver Neoplasms | 4-dichlorobenzene | 62.42 | 17688981 12748734 | |
| MESH:D008113 | Liver Neoplasms | 9,10-Dimethyl-1,2-benzanthracene | 62.42 | 9643874 | |
| MESH:D008113 | Liver Neoplasms | Arsenic | 62.42 | 16368122 | |
| MESH:D008113 | Liver Neoplasms | arsenic trioxide | 62.42 | 14682389 | |
| MESH:D008113 | Liver Neoplasms | Benzo(a)pyrene | 62.42 | 20195826 21137059 | |
| MESH:D008113 | Liver Neoplasms | beta-Naphthoflavone | 62.42 | 19389873 21295105 | |
| MESH:D008113 | Liver Neoplasms | Carbon Tetrachloride | 62.42 | 19294768 | |
| MESH:D008113 | Liver Neoplasms | Chlordan | 62.42 | 2422723 | |
| MESH:D008113 | Liver Neoplasms | DDT | 62.42 | 15975961 11948501 | |
| MESH:D008113 | Liver Neoplasms | Dehydroepiandrosterone | 62.42 | 18709148 | |
| MESH:D008113 | Liver Neoplasms | Dieldrin | 62.42 | 8742319 9539021 | |
| MESH:D008113 | Liver Neoplasms | Diethylhexyl Phthalate | 62.42 | 11940454 | |
| MESH:D008113 | Liver Neoplasms | Diethylstilbestrol | 62.42 | 16712894 15890375 | |
| MESH:D008113 | Liver Neoplasms | Drugs, Chinese Herbal | 62.42 | 18339527 | |
| MESH:D008113 | Liver Neoplasms | Heptachlor | 62.42 | 2422723 9544696 | |
| MESH:D008113 | Liver Neoplasms | Heptachlor Epoxide | 62.42 | 11246134 | |
| MESH:D008113 | Liver Neoplasms | Pentachlorophenol | 62.42 | 10696769 | |
| MESH:D008113 | Liver Neoplasms | perfluorooctanoic acid | 62.42 | 18709148 14757943 | |
| MESH:D008113 | Liver Neoplasms | pirinixic acid | 62.42 | 16377806 20007298 15890375 | |
| MESH:D008113 | Liver Neoplasms | Plant Extracts | 62.42 | 19168119 | |
| MESH:D008113 | Liver Neoplasms | Quercetin | 62.42 | 18980244 | |
| MESH:D008113 | Liver Neoplasms | resveratrol | 62.42 | 20405173 19812893 19321006 19073162 | |
| MESH:D008113 | Liver Neoplasms | Silymarin | 62.42 | 19168119 | |
| MESH:D008113 | Liver Neoplasms | sodium arsenite | 62.42 | 16712894 15276417 | |
| MESH:D008113 | Liver Neoplasms | Tamoxifen | 62.42 | 16684651 | |
| MESH:D008113 | Liver Neoplasms | Tetrachlorodibenzodioxin | 62.42 | 16984957 | |
| MESH:D008113 | Liver Neoplasms | triadimefon | 62.42 | 19028983 | |
| MESH:D008114 | Liver Neoplasms, Experimental | 9,10-Dimethyl-1,2-benzanthracene | 28.03 | 1399818 | |
| MESH:D008114 | Liver Neoplasms, Experimental | arsenic trioxide | 28.03 | 20377131 | |
| MESH:D008114 | Liver Neoplasms, Experimental | beta Carotene | 28.03 | 17113696 | |
| MESH:D008114 | Liver Neoplasms, Experimental | beta-Naphthoflavone | 28.03 | 18164116 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Carbon Tetrachloride | 28.03 | 12014681 15583823 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Dehydroepiandrosterone | 28.03 | 8603461 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Doxorubicin | 28.03 | 17085340 16842330 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Methylcholanthrene | 28.03 | 598648 1399818 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Polychlorinated Biphenyls | 28.03 | 1423854 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Quercetin | 28.03 | 19519916 | |
| MESH:D008114 | Liver Neoplasms, Experimental | systhane | 28.03 | 17178689 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Tetrachlorodibenzodioxin | 28.03 | 12151625 | |
| MESH:D008114 | Liver Neoplasms, Experimental | triadimefon | 28.03 | 17178689 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Vitamin A | 28.03 | 17113696 | |
| MESH:D008133 | Long QT Syndrome | arsenic trioxide | 2.08 | 15213294 | |
| MESH:D038061 | Lower Extremity Deformities, Congenital | Methylnitrosourea | 3.90 | 16080182 | |
| MESH:D008171 | Lung Diseases | nitrofen | 5.35 | 9859898 17245593 16863852 9614859 | |
| MESH:D008171 | Lung Diseases | sodium arsenite | 5.35 | 19095001 | |
| MESH:D008171 | Lung Diseases | Vitamin A | 5.35 | 16863852 | |
| MESH:D017563 | Lung Diseases, Interstitial | Valproic Acid | 2.68 | 17228818 | |
| MESH:D055370 | Lung Injury | Lipopolysaccharides | 4.47 | 21114838 | |
| MESH:D055370 | Lung Injury | Oxygen | 4.47 | 18339021 | |
| MESH:D008175 | Lung Neoplasms | marker/mechanism | 11872642 17077188 | ||
| MESH:D008175 | Lung Neoplasms | 9,10-Dimethyl-1,2-benzanthracene | 30.20 | 11376689 | |
| MESH:D008175 | Lung Neoplasms | alitretinoin | 30.20 | 16413115 | |
| MESH:D008175 | Lung Neoplasms | Arsenic | 30.20 | 17976673 17306315 19168569 | |
| MESH:D008175 | Lung Neoplasms | arsenic trioxide | 30.20 | 19825857 11798837 | |
| MESH:D008175 | Lung Neoplasms | arsenite | 30.20 | 16809336 | |
| MESH:D008175 | Lung Neoplasms | Benzo(a)pyrene | 30.20 | 18569708 20869020 20464547 20135361 18816296 20064080 18520028 6695378 17053015 | |
| MESH:D008175 | Lung Neoplasms | Beryllium | 30.20 | 8933044 9255578 9715507 7545909 | |
| MESH:D008175 | Lung Neoplasms | beta Carotene | 30.20 | 16401635 | |
| MESH:D008175 | Lung Neoplasms | bexarotene | 30.20 | 17849452 | |
| MESH:D008175 | Lung Neoplasms | Curcumin | 30.20 | 19359593 16243823 18462866 | |
| MESH:D008175 | Lung Neoplasms | Dexamethasone | 30.20 | 15824018 11195469 | |
| MESH:D008175 | Lung Neoplasms | Doxorubicin | 30.20 | 6189445 17418594 | |
| MESH:D008175 | Lung Neoplasms | Drugs, Chinese Herbal | 30.20 | 18339527 | |
| MESH:D008175 | Lung Neoplasms | Melatonin | 30.20 | 17195641 | |
| MESH:D008175 | Lung Neoplasms | Methylcholanthrene | 30.20 | 17909032 10545420 7750092 21163286 16337739 20512841 20970405 1399818 15390079 6695378 9230183 11893704 16271038 | |
| MESH:D008175 | Lung Neoplasms | Methylnitrosourea | 30.20 | 18062963 | |
| MESH:D008175 | Lung Neoplasms | Plant Extracts | 30.20 | 20869020 | |
| MESH:D008175 | Lung Neoplasms | Quercetin | 30.20 | 16280456 | |
| MESH:D008175 | Lung Neoplasms | silybin | 30.20 | 16788158 | |
| MESH:D008175 | Lung Neoplasms | sodium arsenite | 30.20 | 17306315 19931552 16712894 15276417 17077188 | |
| MESH:D008175 | Lung Neoplasms | Tamoxifen | 30.20 | 18625569 | |
| MESH:D008175 | Lung Neoplasms | Tetrachlorodibenzodioxin | 30.20 | 11884234 19555203 | |
| MESH:D008175 | Lung Neoplasms | Tetradecanoylphorbol Acetate | 30.20 | 11807781 | |
| MESH:D008175 | Lung Neoplasms | vinyl carbamate | 30.20 | 15824018 17363558 12438228 12117777 15172992 17361011 11195469 11134547 16247444 17163412 14755239 16885199 12765245 | |
| MESH:D008180 | Lupus Erythematosus, Systemic | Carbamazepine | 3.51 | 16628512 | |
| MESH:D008180 | Lupus Erythematosus, Systemic | Melatonin | 3.51 | 16373423 | |
| MESH:D008181 | Lupus Nephritis | Diethylstilbestrol | 3.56 | 15166399 | |
| MESH:D008223 | Lymphoma | 9,10-Dimethyl-1,2-benzanthracene | 18.65 | 11376689 | |
| MESH:D008223 | Lymphoma | Curcumin | 18.65 | 18462866 | |
| MESH:D008223 | Lymphoma | Cyclophosphamide | 18.65 | 12854902 | |
| MESH:D008223 | Lymphoma | decitabine | 18.65 | 19470736 | |
| MESH:D008223 | Lymphoma | Diethylstilbestrol | 18.65 | 15700306 | |
| MESH:D008223 | Lymphoma | Doxorubicin | 18.65 | 16098063 | |
| MESH:D008223 | Lymphoma | Methylnitrosourea | 18.65 | 16257854 11418001 | |
| MESH:D008223 | Lymphoma | Pentachlorophenol | 18.65 | 12669308 | |
| MESH:D016393 | Lymphoma, B-Cell | Cyclophosphamide | 8.67 | 16675587 | |
| MESH:D016393 | Lymphoma, B-Cell | Methylnitrosourea | 8.67 | 14633661 | |
| MESH:D016393 | Lymphoma, B-Cell | resveratrol | 8.67 | 17088997 | |
| MESH:D008228 | Lymphoma, Non-Hodgkin | Cyclophosphamide | 9.35 | 11911406 | |
| MESH:D008228 | Lymphoma, Non-Hodgkin | Doxorubicin | 9.35 | 17654614 | |
| MESH:D008228 | Lymphoma, Non-Hodgkin | Paclitaxel | 9.35 | 14749477 | |
| MESH:D008228 | Lymphoma, Non-Hodgkin | resveratrol | 9.35 | 14749477 | |
| MESH:D016399 | Lymphoma, T-Cell | Curcumin | 6.41 | 16173963 | |
| MESH:D016399 | Lymphoma, T-Cell | Doxorubicin | 6.41 | 15621674 | |
| MESH:D016410 | Lymphoma, T-Cell, Cutaneous | bexarotene | 3.58 | 11161223 | |
| MESH:D008231 | Lymphopenia | methyl cellosolve | 4.19 | 3699323 | |
| MESH:D052801 | Male Urogenital Diseases | Diethylstilbestrol | 3.90 | 16002989 | |
| MESH:D015674 | Mammary Neoplasms, Animal | resveratrol | 4.84 | 15688416 | |
| MESH:D015674 | Mammary Neoplasms, Animal | Tamoxifen | 4.84 | 19428831 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | 9,10-Dimethyl-1,2-benzanthracene | 37.19 | 18840765 12844480 1500032 16153821 16082771 10697514 11807958 8985016 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | bexarotene | 37.19 | 19196722 19196723 15591091 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Dehydroepiandrosterone | 37.19 | 16457693 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Doxorubicin | 37.19 | 15458769 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Drugs, Chinese Herbal | 37.19 | 14758024 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Estradiol | 37.19 | 11408345 11807958 16891317 17203775 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | estradiol 3-benzoate | 37.19 | 15375486 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | gefitinib | 37.19 | 18375820 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Genistein | 37.19 | 12929590 14578162 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | LY 353381 | 37.19 | 11731420 12374698 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Methylnitrosourea | 37.19 | 11807958 10838139 12931682 15688392 15113128 16944150 11751437 16827153 10767621 14999141 15313902 17020996 16619500 16051031 14633655 19196723 17131329 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Progesterone | 37.19 | 11408345 17203775 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | resveratrol | 37.19 | 8985016 11606380 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | selenomethylselenocysteine | 37.19 | 15318939 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Tamoxifen | 37.19 | 14580682 16827153 11731420 19196722 19196723 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Tetradecanoylphorbol Acetate | 37.19 | 8985016 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Triclosan | 37.19 | 15358634 | |
| MESH:D020149 | Manganese Poisoning | Estradiol | 7.33 | 19453300 | |
| MESH:D020149 | Manganese Poisoning | Tamoxifen | 7.33 | 19453300 | |
| MESH:D008527 | Medulloblastoma | Tretinoin | 1.90 | 17453147 | |
| MESH:D008545 | Melanoma | Curcumin | 11.72 | 18462866 17885582 | |
| MESH:D008545 | Melanoma | decitabine | 11.72 | 16505122 17785578 | |
| MESH:D008545 | Melanoma | Doxorubicin | 11.72 | 16827129 | |
| MESH:D008545 | Melanoma | Glucose | 11.72 | 14993021 | |
| MESH:D008545 | Melanoma | Paclitaxel | 11.72 | 12025231 16342250 12040289 | |
| MESH:D008545 | Melanoma | resveratrol | 11.72 | 17992120 | |
| MESH:D008545 | Melanoma | sodium arsenite | 11.72 | 19082730 16487513 | |
| MESH:D008545 | Melanoma | Tamoxifen | 11.72 | 12393984 19393235 | |
| MESH:D008545 | Melanoma | temsirolimus | 11.72 | 17508024 | |
| MESH:D008545 | Melanoma | Tretinoin | 11.72 | 16752155 | |
| MESH:D008545 | Melanoma | trichostatin A | 11.72 | 16505122 | |
| MESH:D018328 | Melanoma, Amelanotic | Tamoxifen | 2.61 | 15990972 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 5.69 | 19513568 | |
| MESH:D008546 | Melanoma, Experimental | Cyclophosphamide | 5.69 | 16388313 | |
| MESH:D008569 | Memory Disorders | Curcumin | 4.76 | 17263510 | |
| MESH:D008569 | Memory Disorders | Ethanol | 4.76 | 15451040 18411066 | |
| MESH:D008591 | Meningomyelocele | Tretinoin | 2.86 | 16940565 | |
| MESH:D008607 | Mental Retardation | Carbamazepine | 3.60 | 9014606 | |
| MESH:D008607 | Mental Retardation | Phenytoin | 3.60 | 9212184 | |
| MESH:D008654 | Mesothelioma | marker/mechanism | 15639718 17659810 | ||
| MESH:D008654 | Mesothelioma | Atrazine | 3.35 | 1916698 | |
| MESH:D008654 | Mesothelioma | Doxorubicin | 3.35 | 17638057 | |
| MESH:D008659 | Metabolic Diseases | resveratrol | 2.91 | 17112576 | |
| MESH:D008708 | Methemoglobinemia | malachite green | 4.05 | 18363129 | |
| MESH:D008881 | Migraine Disorders | marker/mechanism | |||
| MESH:D008881 | Migraine Disorders | Phytoestrogens | 3.98 | 12224599 | |
| MESH:D008881 | Migraine Disorders | Valproic Acid | 3.98 | 18803445 18765137 | |
| MESH:D020326 | Migraine without Aura | Cyclic AMP | 3.65 | 11304026 | |
| MESH:D028361 | Mitochondrial Diseases | Doxorubicin | 3.01 | 15792986 | |
| MESH:D018200 | Mixed Tumor, Mullerian | Raloxifene | 3.94 | 15863610 | |
| MESH:D009062 | Mouth Neoplasms | Benzo(a)pyrene | 4.47 | 16381670 | |
| MESH:D009062 | Mouth Neoplasms | Plant Preparations | 4.47 | 17418620 | |
| MESH:D052016 | Mucositis | Doxorubicin | 3.21 | 17415656 | |
| MESH:D009101 | Multiple Myeloma | alachlor | 23.75 | 14769641 | |
| MESH:D009101 | Multiple Myeloma | arsenic trioxide | 23.75 | 19549372 19417148 14977855 15949261 11468182 | |
| MESH:D009101 | Multiple Myeloma | Curcumin | 23.75 | 19372569 | |
| MESH:D009101 | Multiple Myeloma | decitabine | 23.75 | 18172295 | |
| MESH:D009101 | Multiple Myeloma | Dexamethasone | 23.75 | 16118317 15867202 15744524 | |
| MESH:D009101 | Multiple Myeloma | Paclitaxel | 23.75 | 14749477 | |
| MESH:D009101 | Multiple Myeloma | Raloxifene | 23.75 | 16497877 | |
| MESH:D009101 | Multiple Myeloma | resveratrol | 23.75 | 17164350 17049120 16267019 16490592 17935668 14749477 | |
| MESH:D009101 | Multiple Myeloma | trichostatin A | 23.75 | 18172295 | |
| MESH:D009101 | Multiple Myeloma | Vitamin A | 23.75 | 16374440 | |
| MESH:D009134 | Muscular Atrophy, Spinal | Curcumin | 7.17 | 17962980 | |
| MESH:D009134 | Muscular Atrophy, Spinal | resveratrol | 7.17 | 17962980 | |
| MESH:D009135 | Muscular Diseases | pirinixic acid | 1.98 | 16239165 | |
| MESH:D009139 | Musculoskeletal Abnormalities | Valproic Acid | 2.56 | 8888407 | |
| MESH:D009145 | Mushroom Poisoning | Silymarin | 5.32 | 17213517 | |
| MESH:D009182 | Mycosis Fungoides | arsenic trioxide | 3.07 | 18349030 | |
| MESH:D009190 | Myelodysplastic Syndromes | arsenic trioxide | 10.56 | 16105982 16882451 | |
| MESH:D009190 | Myelodysplastic Syndromes | decitabine | 10.56 | 19157545 18608210 19010910 16882708 | |
| MESH:D009190 | Myelodysplastic Syndromes | Dexamethasone | 10.56 | 9809623 | |
| MESH:D009190 | Myelodysplastic Syndromes | Tretinoin | 10.56 | 17596541 | |
| MESH:D009190 | Myelodysplastic Syndromes | Valproic Acid | 10.56 | 17596541 | |
| MESH:D009203 | Myocardial Infarction | marker/mechanism | |||
| MESH:D009203 | Myocardial Infarction | Doxorubicin | 7.19 | 15857846 19429709 | |
| MESH:D009203 | Myocardial Infarction | Genistein | 7.19 | 17141266 | |
| MESH:D009203 | Myocardial Infarction | pirinixic acid | 7.19 | 19151258 | |
| MESH:D009203 | Myocardial Infarction | Quercetin | 7.19 | 19595682 | |
| MESH:D009203 | Myocardial Infarction | resveratrol | 7.19 | 17015251 17188708 16456233 16525036 17125593 16317513 | |
| MESH:D017202 | Myocardial Ischemia | Arsenic | 10.64 | 15371236 | |
| MESH:D017202 | Myocardial Ischemia | Dioxins | 10.64 | 19057694 | |
| MESH:D017202 | Myocardial Ischemia | resveratrol | 10.64 | 17125593 17015251 | |
| MESH:D017202 | Myocardial Ischemia | Tetrachlorodibenzodioxin | 10.64 | 12213967 | |
| MESH:D015428 | Myocardial Reperfusion Injury | dong quai | 12.43 | 10815014 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Estradiol | 12.43 | 16810080 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Genistein | 12.43 | 17141266 | |
| MESH:D015428 | Myocardial Reperfusion Injury | pirinixic acid | 12.43 | 16411023 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Quercetin | 12.43 | 19207477 | |
| MESH:D009205 | Myocarditis | resveratrol | 3.18 | 17322642 | |
| MESH:D020191 | Myoclonic Epilepsies, Progressive | Phenytoin | 3.94 | 17484760 | |
| MESH:D009224 | Myotonia Congenita | Carbamazepine | 7.24 | 20399394 | |
| MESH:D009224 | Myotonia Congenita | Phenytoin | 7.24 | 1896199 | |
| MESH:D009232 | Myxoma | Raloxifene | 3.94 | 16343187 | |
| MESH:D009336 | Necrosis | Melatonin | 3.91 | 12195237 | |
| MESH:D009361 | Neoplasm Invasiveness | arsenic trioxide | 5.28 | 16624393 | |
| MESH:D009361 | Neoplasm Invasiveness | Curcumin | 5.28 | 18495463 | |
| MESH:D009362 | Neoplasm Metastasis | marker/mechanism | 20104649 | ||
| MESH:D009362 | Neoplasm Metastasis | Doxorubicin | 3.95 | 18259882 | |
| MESH:D009362 | Neoplasm Metastasis | Paclitaxel | 3.95 | 15867366 | |
| MESH:D009362 | Neoplasm Metastasis | Tamoxifen | 3.95 | 19393235 | |
| MESH:D009364 | Neoplasm Recurrence, Local | marker/mechanism | 20556506 | ||
| MESH:D009364 | Neoplasm Recurrence, Local | Tamoxifen | 1.77 | 19410462 | |
| MESH:D009369 | Neoplasms | 2,4,5,2',4',5'-hexachlorobiphenyl | 45.03 | 8820588 | |
| MESH:D009369 | Neoplasms | 9,10-Dimethyl-1,2-benzanthracene | 45.03 | 11544531 | |
| MESH:D009369 | Neoplasms | alitretinoin | 45.03 | 16946489 | |
| MESH:D009369 | Neoplasms | Benzo(a)pyrene | 45.03 | 11141357 | |
| MESH:D009369 | Neoplasms | beta Carotene | 45.03 | 17051425 | |
| MESH:D009369 | Neoplasms | Cyclophosphamide | 45.03 | 18854779 | |
| MESH:D009369 | Neoplasms | DDT | 45.03 | 8820588 | |
| MESH:D009369 | Neoplasms | decitabine | 45.03 | 17925555 19116145 19470736 | |
| MESH:D009369 | Neoplasms | Dieldrin | 45.03 | 8820588 | |
| MESH:D009369 | Neoplasms | Diethylstilbestrol | 45.03 | 15313581 | |
| MESH:D009369 | Neoplasms | fenvalerate | 45.03 | 2895627 | |
| MESH:D009369 | Neoplasms | Lindane | 45.03 | 16818664 12807735 | |
| MESH:D009369 | Neoplasms | lycopene | 45.03 | 17051425 | |
| MESH:D009369 | Neoplasms | Methylnitrosourea | 45.03 | 15533788 | |
| MESH:D009369 | Neoplasms | naringenin | 45.03 | 15185748 | |
| MESH:D009369 | Neoplasms | phytoene | 45.03 | 17051425 | |
| MESH:D009369 | Neoplasms | phytofluene | 45.03 | 17051425 | |
| MESH:D009369 | Neoplasms | pirinixic acid | 45.03 | 17405874 | |
| MESH:D009369 | Neoplasms | Quercetin | 45.03 | 15185748 | |
| MESH:D009369 | Neoplasms | sodium arsenite | 45.03 | 11559025 | |
| MESH:D009369 | Neoplasms | Toxaphene | 45.03 | 8820588 | |
| MESH:D009369 | Neoplasms | Tretinoin | 45.03 | 16594593 16946489 | |
| MESH:D009374 | Neoplasms, Experimental | Captan | 9.49 | 8441825 | |
| MESH:D009374 | Neoplasms, Experimental | Methylnitrosourea | 9.49 | 12696579 | |
| MESH:D009374 | Neoplasms, Experimental | resveratrol | 9.49 | 8985016 | |
| MESH:D009374 | Neoplasms, Experimental | sodium arsenite | 9.49 | 20056578 | |
| MESH:D009376 | Neoplasms, Hormone-Dependent | bexarotene | 13.28 | 19196722 | |
| MESH:D009376 | Neoplasms, Hormone-Dependent | Curcumin | 13.28 | 12497104 | |
| MESH:D009376 | Neoplasms, Hormone-Dependent | Phytoestrogens | 13.28 | 16912569 | |
| MESH:D009376 | Neoplasms, Hormone-Dependent | Tamoxifen | 13.28 | 19196722 19189210 19200415 | |
| MESH:D018301 | Neoplasms, Mesothelial | Pentachlorophenol | 5.04 | 10696769 | |
| MESH:D009389 | Neovascularization, Pathologic | arsenite | 4.99 | 15738583 | |
| MESH:D009389 | Neovascularization, Pathologic | Estradiol | 4.99 | 17289903 | |
| MESH:D009401 | Nephrosis | Doxorubicin | 3.21 | 16636307 16899518 | |
| MESH:D009404 | Nephrotic Syndrome | Doxorubicin | 2.60 | 16889571 15640375 | |
| MESH:D009422 | Nervous System Diseases | Dicofol | 4.28 | 1856875 | |
| MESH:D009421 | Nervous System Malformations | Benomyl | 28.00 | 14502586 | |
| MESH:D009421 | Nervous System Malformations | bisphenol A | 28.00 | 16427766 11399458 | |
| MESH:D009421 | Nervous System Malformations | Carbamazepine | 28.00 | 16990009 | |
| MESH:D009421 | Nervous System Malformations | Diethylstilbestrol | 28.00 | 11399458 | |
| MESH:D009421 | Nervous System Malformations | Estradiol | 28.00 | 16427766 11399458 | |
| MESH:D009421 | Nervous System Malformations | Genistein | 28.00 | 16427766 | |
| MESH:D009421 | Nervous System Malformations | Tetrachlorodibenzodioxin | 28.00 | 14600291 | |
| MESH:D009421 | Nervous System Malformations | Tretinoin | 28.00 | 9125849 | |
| MESH:D009423 | Nervous System Neoplasms | Curcumin | 4.01 | 18462866 | |
| MESH:D009436 | Neural Tube Defects | Arsenic | 15.27 | 16620997 | |
| MESH:D009436 | Neural Tube Defects | arsenic trioxide | 15.27 | 10525206 | |
| MESH:D009436 | Neural Tube Defects | Phenytoin | 15.27 | 9118846 | |
| MESH:D009436 | Neural Tube Defects | sodium arsenite | 15.27 | 12854658 | |
| MESH:D009436 | Neural Tube Defects | Tretinoin | 15.27 | 9142499 | |
| MESH:D009436 | Neural Tube Defects | Valproic Acid | 15.27 | 8888407 16359493 | |
| MESH:D009436 | Neural Tube Defects | Vitamin A | 15.27 | 17400914 | |
| OMIM:601634 | NEURAL TUBE DEFECTS, FOLATE-SENSITIVE | Methanol | 4.99 | 8946559 | |
| MESH:D009442 | Neurilemmoma | Methylnitrosourea | 3.90 | 11555667 | |
| MESH:D019954 | Neurobehavioral Manifestations | 2,3,3',4,4',5-hexachlorobiphenyl | 7.54 | 19647017 | |
| MESH:D019954 | Neurobehavioral Manifestations | Plant Extracts | 7.54 | 17168769 | |
| MESH:D009447 | Neuroblastoma | Cyclophosphamide | 3.56 | 8761367 15176712 16115947 | |
| MESH:D009447 | Neuroblastoma | Doxorubicin | 3.56 | 15555623 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 6.24 | 18514411 | |
| MESH:D019636 | Neurodegenerative Diseases | Oxidopamine | 6.24 | 18514411 | |
| MESH:D019636 | Neurodegenerative Diseases | resveratrol | 6.24 | 17652729 | |
| MESH:D017599 | Neuroectodermal Tumors | Cyclophosphamide | 3.32 | 12837982 8761367 | |
| MESH:D020078 | Neurogenic Inflammation | Arsenic | 9.17 | 17056641 | |
| MESH:D020078 | Neurogenic Inflammation | Quercetin | 9.17 | 17929310 | |
| MESH:D020078 | Neurogenic Inflammation | resveratrol | 9.17 | 17929310 | |
| MESH:D020258 | Neurotoxicity Syndromes | Aldicarb | 6.30 | 15081274 | |
| MESH:D020258 | Neurotoxicity Syndromes | Chlorpyrifos | 6.30 | 15081274 | |
| MESH:D020258 | Neurotoxicity Syndromes | Methyl Parathion | 6.30 | 19784758 | |
| MESH:D009503 | Neutropenia | Cyclophosphamide | 2.89 | 8291058 | |
| MESH:D052556 | Niemann-Pick Disease, Type C | perfluorooctanoic acid | 3.40 | 9802331 | |
| MESH:D009669 | Nose Neoplasms | alachlor | 3.34 | 16698726 16178123 11127290 15580706 14563481 | |
| MESH:D009765 | Obesity | Curcumin | 3.16 | 19297423 | |
| MESH:D009765 | Obesity | pirinixic acid | 3.16 | 20558911 | |
| MESH:D009765 | Obesity | Plant Extracts | 3.16 | 19056576 20132043 | |
| MESH:D009845 | Oligospermia | Cyclophosphamide | 5.95 | 16517039 | |
| MESH:D009845 | Oligospermia | methyl cellosolve | 5.95 | 3987992 | |
| MESH:D010014 | Osteolysis | Paclitaxel | 3.40 | 15867366 | |
| MESH:D010018 | Osteomalacia | Carbamazepine | 7.24 | 17016548 | |
| MESH:D010018 | Osteomalacia | Phenytoin | 7.24 | 17016548 | |
| MESH:D010024 | Osteoporosis | Curcumin | 12.04 | 18719352 | |
| MESH:D010024 | Osteoporosis | Genistein | 12.04 | 19401787 | |
| MESH:D010024 | Osteoporosis | Isoflavones | 12.04 | 16562857 | |
| MESH:D010024 | Osteoporosis | kaempferol | 12.04 | 16756079 | |
| MESH:D010024 | Osteoporosis | ormeloxifene | 12.04 | 15261309 | |
| MESH:D010024 | Osteoporosis | Raloxifene | 12.04 | 17882678 15775268 19059307 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | Dehydroepiandrosterone | 24.82 | 16397352 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | Drugs, Chinese Herbal | 24.82 | 16548355 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | Genistein | 24.82 | 16169203 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | LY 117018 | 24.82 | 17907171 17638036 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | Quercetin | 24.82 | 19495926 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | Raloxifene | 24.82 | 15579764 17823083 15758505 17893378 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | resveratrol | 24.82 | 17513867 | |
| MESH:D012516 | Osteosarcoma | Doxorubicin | 2.73 | 15930896 | |
| MESH:D010049 | Ovarian Diseases | bisphenol A | 3.39 | 11985600 | |
| MESH:D010051 | Ovarian Neoplasms | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 38.27 | 16211241 | |
| MESH:D010051 | Ovarian Neoplasms | 9,10-Dimethyl-1,2-benzanthracene | 38.27 | 16891317 | |
| MESH:D010051 | Ovarian Neoplasms | Arsenic | 38.27 | 17306315 | |
| MESH:D010051 | Ovarian Neoplasms | arsenic trioxide | 38.27 | 12452020 19769630 16624393 | |
| MESH:D010051 | Ovarian Neoplasms | Curcumin | 38.27 | 19020741 18462866 | |
| MESH:D010051 | Ovarian Neoplasms | decitabine | 38.27 | 19259094 19331143 | |
| MESH:D010051 | Ovarian Neoplasms | Estradiol | 38.27 | 19401270 | |
| MESH:D010051 | Ovarian Neoplasms | Genistein | 38.27 | 19005980 | |
| MESH:D010051 | Ovarian Neoplasms | Luteolin | 38.27 | 19005980 | |
| MESH:D010051 | Ovarian Neoplasms | Medroxyprogesterone Acetate | 38.27 | 17393432 | |
| MESH:D010051 | Ovarian Neoplasms | Mifepristone | 38.27 | 16525653 | |
| MESH:D010051 | Ovarian Neoplasms | Paclitaxel | 38.27 | 11161223 | |
| MESH:D010051 | Ovarian Neoplasms | Progesterone | 38.27 | 16525653 17393432 | |
| MESH:D010051 | Ovarian Neoplasms | Quercetin | 38.27 | 19005980 | |
| MESH:D010051 | Ovarian Neoplasms | sodium arsenite | 38.27 | 15276417 17306315 | |
| MESH:D010051 | Ovarian Neoplasms | Tretinoin | 38.27 | 16936753 | |
| MESH:D010051 | Ovarian Neoplasms | trichostatin A | 38.27 | 19331143 | |
| MESH:D010051 | Ovarian Neoplasms | U 0126 | 38.27 | 16211241 | |
| MESH:D010146 | Pain | Acetaminophen | 7.11 | 16870215 | |
| MESH:D010146 | Pain | Carbamazepine | 7.11 | 15215642 | |
| MESH:D010146 | Pain | Cyclophosphamide | 7.11 | 18093676 12161096 | |
| MESH:D010146 | Pain | Phenytoin | 7.11 | 15215642 | |
| MESH:D010146 | Pain | Tretinoin | 7.11 | 16870215 | |
| MESH:D010190 | Pancreatic Neoplasms | arsenic trioxide | 20.25 | 15580305 | |
| MESH:D010190 | Pancreatic Neoplasms | Curcumin | 20.25 | 19196508 17440100 19401701 | |
| MESH:D010190 | Pancreatic Neoplasms | Cyclophosphamide | 20.25 | 11332152 | |
| MESH:D010190 | Pancreatic Neoplasms | decitabine | 20.25 | 19294695 | |
| MESH:D010190 | Pancreatic Neoplasms | Ethanol | 20.25 | 12384795 | |
| MESH:D010190 | Pancreatic Neoplasms | Methylnitrosourea | 20.25 | 16965848 | |
| MESH:D010190 | Pancreatic Neoplasms | pendimethalin | 20.25 | 19142867 | |
| MESH:D010190 | Pancreatic Neoplasms | Quercetin | 20.25 | 16965848 | |
| MESH:D010190 | Pancreatic Neoplasms | Tetradecanoylphorbol Acetate | 20.25 | 15976015 | |
| MESH:D010190 | Pancreatic Neoplasms | Tretinoin | 20.25 | 15976015 | |
| MESH:D010190 | Pancreatic Neoplasms | trichostatin A | 20.25 | 19294695 | |
| MESH:D010195 | Pancreatitis | Methomyl | 4.95 | 16258382 15767733 | |
| MESH:D010195 | Pancreatitis | Phytoestrogens | 4.95 | 17269527 | |
| MESH:D016584 | Panic Disorder | Ethinyl Estradiol | 2.18 | 11578682 | |
| MESH:D010212 | Papilloma | 9,10-Dimethyl-1,2-benzanthracene | 9.95 | 16517061 15173996 17234724 | |
| MESH:D010212 | Papilloma | Benzoyl Peroxide | 9.95 | 8330346 12065085 | |
| MESH:D010212 | Papilloma | Plant Extracts | 9.95 | 16517061 15173996 | |
| MESH:D010212 | Papilloma | Tetradecanoylphorbol Acetate | 9.95 | 12065085 18922899 18404319 8330346 | |
| MESH:D010235 | Paraganglioma | arsenic trioxide | 2.66 | 19927285 | |
| MESH:D010243 | Paralysis | fenvalerate | 4.42 | 8952708 | |
| MESH:D010267 | Parapsoriasis | Carbamazepine | 4.13 | 16538176 | |
| MESH:D010300 | Parkinson Disease | Atrazine | 3.64 | 17218051 | |
| MESH:D010300 | Parkinson Disease | Dieldrin | 3.64 | 16112328 17291500 11445065 11181820 16809432 | |
| MESH:D010300 | Parkinson Disease | Polychlorinated Biphenyls | 3.64 | 16702228 | |
| MESH:D010302 | Parkinson Disease, Secondary | Oxidopamine | 3.92 | 11771942 15893579 | |
| MESH:D020734 | Parkinsonian Disorders | Melatonin | 3.64 | 15574749 | |
| OMIM:167400 | PAROXYSMAL EXTREME PAIN DISORDER | Carbamazepine | 4.33 | 17679678 17145499 | |
| MESH:D010382 | Peliosis Hepatis | Tetrachlorodibenzodioxin | 2.64 | 12520081 | |
| MESH:D010523 | Peripheral Nervous System Diseases | Arsenic | 2.69 | 16093927 | |
| MESH:D016491 | Peripheral Vascular Diseases | Arsenic | 7.83 | 16905509 6392382 15371236 | |
| MESH:D016491 | Peripheral Vascular Diseases | Cadmium | 7.83 | 15687053 | |
| MESH:D010538 | Peritonitis | Melatonin | 3.80 | 15707874 | |
| MESH:D003557 | Phyllodes Tumor | Doxorubicin | 3.54 | 17983394 | |
| MESH:D010900 | Pituitary Diseases | Diethylstilbestrol | 3.56 | 14722030 | |
| MESH:D010911 | Pituitary Neoplasms | Diethylstilbestrol | 3.11 | 15687265 16977796 | |
| MESH:D010997 | Pleural Neoplasms | Doxorubicin | 3.54 | 17638057 | |
| MESH:D011014 | Pneumonia | Lipopolysaccharides | 2.99 | 11605937 12224865 | |
| MESH:D011041 | Poisoning | Methomyl | 5.05 | 11800311 | |
| MESH:D011041 | Poisoning | Methyl Parathion | 5.05 | 17603234 | |
| MESH:D011085 | Polycystic Ovary Syndrome | Flutamide | 3.55 | 15356085 | |
| MESH:D017689 | Polydactyly | Phenytoin | 3.61 | 9212184 | |
| MESH:D011141 | Polyuria | Lithium Chloride | 4.41 | 19692487 | |
| MESH:D017499 | Porokeratosis | alitretinoin | 4.39 | 16144296 | |
| MESH:D017119 | Porphyria Cutanea Tarda | Tetrachlorodibenzodioxin | 2.03 | 18163543 | |
| MESH:D011230 | Precancerous Conditions | Quercetin | 2.59 | 19056647 | |
| MESH:D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | Cyclophosphamide | 3.96 | 21297632 | |
| MESH:D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | Dexamethasone | 3.96 | 21297632 | |
| MESH:D011248 | Pregnancy Complications | Carbamazepine | 6.51 | 9014606 | |
| MESH:D011248 | Pregnancy Complications | Toxaphene | 6.51 | 2087686 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | bisphenol A | 31.22 | 10548101 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Carbamazepine | 31.22 | 9014606 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Diethylstilbestrol | 31.22 | 17184923 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | methyl cellosolve | 31.22 | 7974496 6499817 12530607 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | perfluorooctanoic acid | 31.22 | 17132714 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | resveratrol | 31.22 | 16679765 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Tetrachlorodibenzodioxin | 31.22 | 11118676 11222880 11399792 11896295 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Valproic Acid | 31.22 | 20603192 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | vinclozolin | 31.22 | 18220299 18042343 19015723 | |
| MESH:D055728 | Primary Myelofibrosis | decitabine | 7.25 | 17616702 | |
| MESH:D055728 | Primary Myelofibrosis | trichostatin A | 7.25 | 17616702 | |
| MESH:D011469 | Prostatic Diseases | vinclozolin | 3.34 | 18220299 | |
| MESH:D011470 | Prostatic Hyperplasia | Calcitriol | 3.20 | 15572423 | |
| MESH:D019048 | Prostatic Intraepithelial Neoplasia | marker/mechanism | 16220300 | ||
| MESH:D019048 | Prostatic Intraepithelial Neoplasia | bisphenol A | 9.51 | 20887781 | |
| MESH:D019048 | Prostatic Intraepithelial Neoplasia | Estradiol | 9.51 | 20887781 | |
| MESH:D019048 | Prostatic Intraepithelial Neoplasia | Testosterone | 9.51 | 20887781 | |
| MESH:D011471 | Prostatic Neoplasms | marker/mechanism | 16220300 17176215 | ||
| MESH:D011471 | Prostatic Neoplasms | Apigenin | 28.01 | 17132221 | |
| MESH:D011471 | Prostatic Neoplasms | Arsenic | 28.01 | 16140617 | |
| MESH:D011471 | Prostatic Neoplasms | arsenic trioxide | 28.01 | 19131511 | |
| MESH:D011471 | Prostatic Neoplasms | Benzo(a)pyrene | 28.01 | 17292933 | |
| MESH:D011471 | Prostatic Neoplasms | biochanin A | 28.01 | 12111696 | |
| MESH:D011471 | Prostatic Neoplasms | bisphenol A | 28.01 | 16740699 | |
| MESH:D011471 | Prostatic Neoplasms | Cadmium | 28.01 | 17075824 | |
| MESH:D011471 | Prostatic Neoplasms | Calcitriol | 28.01 | 16289102 12479363 18247401 16644109 15754350 | |
| MESH:D011471 | Prostatic Neoplasms | Coumestrol | 28.01 | 16921512 | |
| MESH:D011471 | Prostatic Neoplasms | Curcumin | 28.01 | 12497104 15129424 18156803 10851300 11398177 18226269 18769126 | |
| MESH:D011471 | Prostatic Neoplasms | Cyclophosphamide | 28.01 | 17136230 | |
| MESH:D011471 | Prostatic Neoplasms | DDT | 28.01 | 12584743 | |
| MESH:D011471 | Prostatic Neoplasms | Dicofol | 28.01 | 12584743 | |
| MESH:D011471 | Prostatic Neoplasms | Diethylstilbestrol | 28.01 | 15046698 17136230 15846301 | |
| MESH:D011471 | Prostatic Neoplasms | Doxorubicin | 28.01 | 16888761 15897917 15749863 18437689 16868541 16729912 | |
| MESH:D011471 | Prostatic Neoplasms | equol | 28.01 | 16925846 16898868 | |
| MESH:D011471 | Prostatic Neoplasms | Estradiol | 28.01 | 16740699 | |
| MESH:D011471 | Prostatic Neoplasms | fisetin | 28.01 | 18922931 | |
| MESH:D011471 | Prostatic Neoplasms | Flutamide | 28.01 | 3169114 | |
| MESH:D011471 | Prostatic Neoplasms | gefitinib | 28.01 | 15651060 17914592 16685379 | |
| MESH:D011471 | Prostatic Neoplasms | Genistein | 28.01 | 15378649 15256057 16925846 | |
| MESH:D011471 | Prostatic Neoplasms | Heptachlor | 28.01 | 12661182 | |
| MESH:D011471 | Prostatic Neoplasms | Isoflavones | 28.01 | 17571952 16365062 17374662 17219775 | |
| MESH:D011471 | Prostatic Neoplasms | Ketoconazole | 28.01 | 17404083 | |
| MESH:D011471 | Prostatic Neoplasms | Lindane | 28.01 | 14688026 12661182 | |
| MESH:D011471 | Prostatic Neoplasms | lycopene | 28.01 | 17337101 15084515 | |
| MESH:D011471 | Prostatic Neoplasms | Methylnitrosourea | 28.01 | 15682402 12376480 | |
| MESH:D011471 | Prostatic Neoplasms | methylselenic acid | 28.01 | 16205645 | |
| MESH:D011471 | Prostatic Neoplasms | O-desmethylangolensin | 28.01 | 16925846 | |
| MESH:D011471 | Prostatic Neoplasms | Paclitaxel | 28.01 | 17136230 17172428 16729912 16356831 | |
| MESH:D011471 | Prostatic Neoplasms | Phytoestrogens | 28.01 | 16921512 | |
| MESH:D011471 | Prostatic Neoplasms | Plant Extracts | 28.01 | 17804756 14666653 | |
| MESH:D011471 | Prostatic Neoplasms | Polychlorinated Biphenyls | 28.01 | 15721890 | |
| MESH:D011471 | Prostatic Neoplasms | Quercetin | 28.01 | 17292933 14715546 | |
| MESH:D011471 | Prostatic Neoplasms | Raloxifene | 28.01 | 16220300 15731164 16536755 | |
| MESH:D011471 | Prostatic Neoplasms | resveratrol | 28.01 | 15767336 17675339 17718901 17636462 16731767 17804756 | |
| MESH:D011471 | Prostatic Neoplasms | Simazine | 28.01 | 12661182 | |
| MESH:D011471 | Prostatic Neoplasms | sodium arsenite | 28.01 | 16039940 | |
| MESH:D011471 | Prostatic Neoplasms | sulindac sulfone | 28.01 | 17908994 15570007 | |
| MESH:D011471 | Prostatic Neoplasms | Tamoxifen | 28.01 | 15067354 | |
| MESH:D011471 | Prostatic Neoplasms | trichostatin A | 28.01 | 19789329 18798265 | |
| MESH:D011472 | Prostatitis | vinclozolin | 3.34 | 18629315 | |
| MESH:D011507 | Proteinuria | Arsenic | 4.38 | 21343184 | |
| MESH:D011507 | Proteinuria | Tretinoin | 4.38 | 16636307 | |
| MESH:D011537 | Pruritus | Ethinyl Estradiol | 1.80 | 15861022 16919318 | |
| MESH:D019310 | Pseudolymphoma | Carbamazepine | 12.12 | 9591791 12752131 | |
| MESH:D019310 | Pseudolymphoma | Phenytoin | 12.12 | 8603615 1419762 12752131 | |
| MESH:D019310 | Pseudolymphoma | Valproic Acid | 12.12 | 11422049 12752131 | |
| MESH:D011625 | Pterygium | Tretinoin | 3.20 | 16723453 | |
| MESH:D011629 | Puberty, Precocious | bisphenol A | 3.20 | 10548101 | |
| MESH:D011649 | Pulmonary Alveolar Proteinosis | 27-hydroxycholesterol | 4.78 | 15466366 | |
| MESH:D011656 | Pulmonary Emphysema | Curcumin | 3.07 | 19168576 | |
| MESH:D011658 | Pulmonary Fibrosis | Cyclophosphamide | 4.12 | 16636934 | |
| MESH:D011658 | Pulmonary Fibrosis | Drugs, Chinese Herbal | 4.12 | 16987627 | |
| MESH:D011658 | Pulmonary Fibrosis | gefitinib | 4.12 | 18424623 | |
| MESH:D011693 | Purpura | Raloxifene | 3.94 | 15770314 | |
| MESH:D012003 | Rectal Fistula | Drugs, Chinese Herbal | 4.35 | 15043669 | |
| MESH:D051437 | Renal Insufficiency | Doxorubicin | 2.70 | 17922066 | |
| MESH:D051436 | Renal Insufficiency, Chronic | resveratrol | 3.97 | 16325855 | |
| MESH:D015427 | Reperfusion Injury | pirinixic acid | 3.02 | 19058328 | |
| MESH:D015427 | Reperfusion Injury | resveratrol | 3.02 | 15827377 16314181 17520802 17058453 16317513 | |
| MESH:D012128 | Respiratory Distress Syndrome, Adult | Curcumin | 6.81 | 18379247 10666014 | |
| MESH:D012128 | Respiratory Distress Syndrome, Adult | Dexamethasone | 6.81 | 18379247 11700416 | |
| MESH:D012128 | Respiratory Distress Syndrome, Adult | Oxygen | 6.81 | 18339021 17627322 | |
| MESH:D012127 | Respiratory Distress Syndrome, Newborn | Vitamin A | 4.21 | 16877224 | |
| MESH:D012130 | Respiratory Hypersensitivity | Acetylcholine | 4.37 | 9413022 | |
| MESH:D012130 | Respiratory Hypersensitivity | Lipopolysaccharides | 4.37 | 10835634 | |
| MESH:D012135 | Respiratory Sounds | alachlor | 7.55 | 11874814 | |
| MESH:D012135 | Respiratory Sounds | Atrazine | 7.55 | 11874814 | |
| MESH:D012135 | Respiratory Sounds | Chlorpyrifos | 7.55 | 16611668 11874814 17119214 | |
| MESH:D015619 | Respiratory System Abnormalities | Tetrachlorodibenzodioxin | 2.30 | 18990726 | |
| MESH:D012140 | Respiratory Tract Diseases | Chlorpyrifos | 3.33 | 16611668 17119214 | |
| MESH:D012162 | Retinal Degeneration | Methylnitrosourea | 3.10 | 18172121 18155124 | |
| MESH:D012175 | Retinoblastoma | Methylnitrosourea | 3.90 | 11555667 | |
| MESH:D012208 | Rhabdomyosarcoma | decitabine | 9.85 | 19155313 | |
| MESH:D012208 | Rhabdomyosarcoma | Tretinoin | 9.85 | 16283617 16116481 | |
| MESH:D012208 | Rhabdomyosarcoma | Valproic Acid | 9.85 | 19155313 | |
| MESH:D012221 | Rhinitis, Allergic, Perennial | Drugs, Chinese Herbal | 3.69 | 15015336 | |
| MESH:D012468 | Salivary Gland Neoplasms | Progesterone | 2.05 | 18045962 | |
| MESH:D012509 | Sarcoma | Curcumin | 4.79 | 18462866 | |
| MESH:D012509 | Sarcoma | Doxorubicin | 4.79 | 15625365 16767912 18313854 17203757 17710206 15675481 | |
| MESH:D012512 | Sarcoma, Ewing's | arsenic trioxide | 5.24 | 16646077 | |
| MESH:D012512 | Sarcoma, Ewing's | Doxorubicin | 5.24 | 16326096 14601052 | |
| MESH:D012514 | Sarcoma, Kaposi | Doxorubicin | 3.21 | 17846226 | |
| MESH:D012554 | Schistosomiasis japonica | Quercetin | 3.93 | 16862918 | |
| MESH:D012559 | Schizophrenia | Valproic Acid | 1.93 | 19110320 15737665 | |
| MESH:D012595 | Scleroderma, Systemic | Cyclophosphamide | 3.32 | 16636934 | |
| MESH:D012640 | Seizures | Carbamazepine | 9.39 | 16876388 16180713 9046859 9844417 16938433 15946322 19414003 | |
| MESH:D012640 | Seizures | Endosulfan | 9.39 | 10698677 7539098 | |
| MESH:D012640 | Seizures | Ethanol | 9.39 | 9754883 | |
| MESH:D012640 | Seizures | Lindane | 9.39 | 12842176 15475178 7539098 | |
| MESH:D012640 | Seizures | Methomyl | 9.39 | 12660363 11218047 | |
| MESH:D012640 | Seizures | Phenytoin | 9.39 | 16876388 3137016 19919933 10029267 3691417 15946322 9844417 11044598 | |
| MESH:D012640 | Seizures | Valproic Acid | 9.39 | 11044598 11738929 14763951 16876388 3137016 15475178 1511512 17978042 | |
| MESH:D018805 | Sepsis | Curcumin | 5.47 | 18389075 | |
| MESH:D018805 | Sepsis | dong quai | 5.47 | 16424112 | |
| MESH:D012729 | Sex Chromosome Aberrations | Chlorpyrifos | 4.47 | 6418539 | |
| MESH:D012735 | Sexual Dysfunction, Physiological | Testosterone | 4.58 | 16631401 | |
| MESH:D012852 | Sinusitis | Phenylephrine | 3.14 | 7327846 | |
| MESH:D012871 | Skin Diseases | Arsenic | 2.93 | 17548696 19834688 16353154 15952646 16702368 17050553 18709164 16759981 6392382 17453740 17938729 | |
| MESH:D012871 | Skin Diseases | Vitamin A | 2.93 | 18709164 | |
| MESH:D012878 | Skin Neoplasms | 9,10-Dimethyl-1,2-benzanthracene | 26.95 | 15173996 11376689 8985016 16517061 | |
| MESH:D012878 | Skin Neoplasms | Arsenic | 26.95 | 17976673 17029826 16251483 15504454 19538983 17050553 | |
| MESH:D012878 | Skin Neoplasms | Benzo(a)pyrene | 26.95 | 19755658 10029692 | |
| MESH:D012878 | Skin Neoplasms | Benzoyl Peroxide | 26.95 | 12065085 8532709 8330346 | |
| MESH:D012878 | Skin Neoplasms | Doxorubicin | 26.95 | 15692506 | |
| MESH:D012878 | Skin Neoplasms | Glucose | 26.95 | 14993021 | |
| MESH:D012878 | Skin Neoplasms | Okadaic Acid | 26.95 | 12628509 | |
| MESH:D012878 | Skin Neoplasms | Plant Extracts | 26.95 | 15173996 16517061 | |
| MESH:D012878 | Skin Neoplasms | resveratrol | 26.95 | 8985016 15837718 | |
| MESH:D012878 | Skin Neoplasms | sodium arsenite | 26.95 | 18572023 19524636 | |
| MESH:D012878 | Skin Neoplasms | Tetrachlorodibenzodioxin | 26.95 | 16192470 | |
| MESH:D012878 | Skin Neoplasms | Tetradecanoylphorbol Acetate | 26.95 | 18404319 11807781 8330346 8985016 12065085 | |
| MESH:D012878 | Skin Neoplasms | Tretinoin | 26.95 | 16467112 | |
| MESH:D012893 | Sleep Disorders | Carbamazepine | 6.21 | 19414003 | |
| MESH:D012893 | Sleep Disorders | Melatonin | 6.21 | 18182647 16897403 16919138 | |
| MESH:D020178 | Sleep Disorders, Circadian Rhythm | Melatonin | 5.02 | 18078449 19452292 | |
| MESH:D007319 | Sleep Initiation and Maintenance Disorders | Melatonin | 3.71 | 18078449 | |
| MESH:D019082 | Smith-Lemli-Opitz Syndrome | 24-hydroxycholesterol | 8.19 | 11254748 | |
| MESH:D019082 | Smith-Lemli-Opitz Syndrome | 27-hydroxycholesterol | 8.19 | 11254748 | |
| MESH:D012983 | Soft Tissue Neoplasms | Doxorubicin | 3.02 | 16767912 17203757 15625365 | |
| OMIM:270800 | SPASTIC PARAPLEGIA 5A, AUTOSOMAL RECESSIVE | 27-hydroxycholesterol | 4.78 | 19812052 | |
| MESH:D013088 | Spermatocele | Diethylstilbestrol | 16.35 | 16002989 16709447 | |
| MESH:D013088 | Spermatocele | Ethinyl Estradiol | 16.35 | 16709447 | |
| MESH:D013088 | Spermatocele | Tamoxifen | 16.35 | 16709447 | |
| MESH:D013088 | Spermatocele | Toremifene | 16.35 | 16709447 | |
| OMIM:102530 | SPERMATOGENIC FAILURE 6 | Cyclophosphamide | 3.92 | 16517039 | |
| MESH:D013119 | Spinal Cord Injuries | Progesterone | 5.66 | 16503802 15862959 | |
| MESH:D013119 | Spinal Cord Injuries | Tamoxifen | 5.66 | 19457130 | |
| MESH:D016135 | Spinal Dysraphism | sodium arsenite | 4.98 | 12854658 | |
| MESH:D016135 | Spinal Dysraphism | Valproic Acid | 4.98 | 19490988 | |
| MESH:D013160 | Splenic Neoplasms | Pentachlorophenol | 4.70 | 10696769 | |
| MESH:D013226 | Status Epilepticus | Valproic Acid | 2.94 | 12833885 | |
| MESH:D013262 | Stevens-Johnson Syndrome | Carbamazepine | 6.43 | 16538176 16415921 19694795 18855540 19915237 20485159 15057820 | |
| MESH:D013262 | Stevens-Johnson Syndrome | Phenytoin | 6.43 | 20235791 | |
| MESH:D013272 | Stomach Diseases | beta Carotene | 5.45 | 17638125 | |
| MESH:D013272 | Stomach Diseases | Dexamethasone | 5.45 | 15472012 | |
| MESH:D013274 | Stomach Neoplasms | arsenic trioxide | 5.71 | 17007042 | |
| MESH:D013274 | Stomach Neoplasms | Benzo(a)pyrene | 5.71 | 20155912 2093021 | |
| MESH:D013274 | Stomach Neoplasms | Butylated Hydroxyanisole | 5.71 | 1399818 3581430 | |
| MESH:D013274 | Stomach Neoplasms | decitabine | 5.71 | 19037991 | |
| MESH:D013274 | Stomach Neoplasms | Drugs, Chinese Herbal | 5.71 | 18339527 | |
| MESH:D013274 | Stomach Neoplasms | Ethanol | 5.71 | 18456281 | |
| MESH:D013274 | Stomach Neoplasms | Methylnitrosourea | 5.71 | 16257854 18593901 15930296 | |
| MESH:D013274 | Stomach Neoplasms | Paclitaxel | 5.71 | 18396642 18506536 | |
| MESH:D013274 | Stomach Neoplasms | Tretinoin | 5.71 | 17261132 | |
| MESH:D013276 | Stomach Ulcer | beta Carotene | 9.94 | 12500499 | |
| MESH:D013276 | Stomach Ulcer | Curcumin | 9.94 | 16631530 19188055 | |
| MESH:D013276 | Stomach Ulcer | Dexamethasone | 9.94 | 15138204 | |
| MESH:D013276 | Stomach Ulcer | Ethanol | 9.94 | 9211565 16755016 9562338 17918041 17189318 11906479 | |
| MESH:D013276 | Stomach Ulcer | Melatonin | 9.94 | 12500499 16150113 11523592 | |
| MESH:D013276 | Stomach Ulcer | Plant Extracts | 9.94 | 17135157 15255614 12787963 18237397 18193104 | |
| MESH:D020521 | Stroke | Raloxifene | 2.50 | 16837676 | |
| OMIM:601367 | STROKE, ISCHEMIC | resveratrol | 3.02 | 16321402 | |
| MESH:D013345 | Subarachnoid Hemorrhage | Drugs, Chinese Herbal | 4.16 | 17634840 | |
| MESH:D019966 | Substance-Related Disorders | bisphenol A | 2.46 | 16684133 16045194 | |
| MESH:D013375 | Substance Withdrawal Syndrome | Ethanol | 2.83 | 9754883 | |
| MESH:D013398 | Sudden Infant Death | Oxygen | 3.96 | 12563064 | |
| MESH:D015173 | Supratentorial Neoplasms | Cyclophosphamide | 3.48 | 12837982 | |
| MESH:D013576 | Syndactyly | methoxyacetic acid | 4.10 | 1761404 1761407 | |
| MESH:D013610 | Tachycardia | Nitroprusside | 4.10 | 15306635 | |
| MESH:D024801 | Tauopathies | Paclitaxel | 3.25 | 16930453 | |
| MESH:D013705 | Temporomandibular Joint Disorders | Plant Extracts | 3.87 | 17997062 | |
| MESH:D013733 | Testicular Diseases | methoxyacetic acid | 8.63 | 18486176 6499806 | |
| MESH:D013733 | Testicular Diseases | methyl cellosolve | 8.63 | 6499806 | |
| MESH:D013733 | Testicular Diseases | pyrazole | 8.63 | 6499806 | |
| MESH:D013921 | Thrombocytopenia | Lipopolysaccharides | 2.74 | 15821434 | |
| MESH:D019851 | Thrombophilia | Ethinyl Estradiol | 2.12 | 11994571 | |
| MESH:D013927 | Thrombosis | Ethinyl Estradiol | 1.77 | 15669648 | |
| MESH:D013953 | Thymus Neoplasms | Methylnitrosourea | 3.65 | 11418001 | |
| MESH:D013959 | Thyroid Diseases | Tetrachlorodibenzodioxin | 7.19 | 12697716 | |
| MESH:D013959 | Thyroid Diseases | Triclosan | 7.19 | 19910387 | |
| MESH:D013964 | Thyroid Neoplasms | alachlor | 19.51 | 8812207 | |
| MESH:D013964 | Thyroid Neoplasms | arsenic trioxide | 19.51 | 19014326 | |
| MESH:D013964 | Thyroid Neoplasms | Butyrates | 19.51 | 17967635 | |
| MESH:D013964 | Thyroid Neoplasms | decitabine | 19.51 | 17967635 | |
| MESH:D013964 | Thyroid Neoplasms | Doxorubicin | 19.51 | 17909728 16010429 | |
| MESH:D013964 | Thyroid Neoplasms | gefitinib | 19.51 | 16940797 | |
| MESH:D013964 | Thyroid Neoplasms | Methylnitrosourea | 19.51 | 7505956 3078959 | |
| MESH:D013964 | Thyroid Neoplasms | Tretinoin | 19.51 | 16026305 17045167 | |
| MESH:D013964 | Thyroid Neoplasms | triadimefon | 19.51 | 17178689 | |
| MESH:D013978 | Tibial Fractures | Estradiol | 8.39 | 19048282 | |
| MESH:D013978 | Tibial Fractures | Raloxifene | 8.39 | 19048282 | |
| MESH:D014062 | Tongue Neoplasms | resveratrol | 5.09 | 16227395 | |
| MESH:D014062 | Tongue Neoplasms | Tretinoin | 5.09 | 16051514 | |
| MESH:D016171 | Torsades de Pointes | arsenic trioxide | 2.42 | 15213294 | |
| MESH:D014178 | Translocation, Genetic | Valproic Acid | 3.62 | 17262798 | |
| MESH:D014202 | Tremor | Chlordecone | 6.55 | 6175765 | |
| MESH:D014202 | Tremor | fenvalerate | 6.55 | 8952708 | |
| MESH:D014376 | Tuberculosis | Tretinoin | 2.05 | 16040207 | |
| MESH:D020194 | Unverricht-Lundborg Syndrome | Valproic Acid | 2.94 | 3119515 | |
| MESH:D001749 | Urinary Bladder Neoplasms | marker/mechanism | 16712894 | ||
| MESH:D001749 | Urinary Bladder Neoplasms | 2-phenylphenol | 28.96 | 6654951 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Arsenic | 28.96 | 17976673 18640142 19322015 17306315 11144890 19429237 15987713 | |
| MESH:D001749 | Urinary Bladder Neoplasms | arsenic trioxide | 28.96 | 12845720 20435036 11780464 12973940 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Benzo(a)pyrene | 28.96 | 17053015 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Butylated Hydroxyanisole | 28.96 | 1399818 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Curcumin | 28.96 | 18593936 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Cyclophosphamide | 28.96 | 14692829 | |
| MESH:D001749 | Urinary Bladder Neoplasms | decitabine | 28.96 | 17616700 19087683 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Diethylstilbestrol | 28.96 | 17306315 16452187 16712894 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Doxorubicin | 28.96 | 17653716 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Plant Preparations | 28.96 | 11251952 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Quercetin | 28.96 | 16720314 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Raloxifene | 28.96 | 17572228 | |
| MESH:D001749 | Urinary Bladder Neoplasms | sodium arsenite | 28.96 | 16712894 11723127 17306315 16452187 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Tamoxifen | 28.96 | 16712894 17572228 8653321 | |
| MESH:D014564 | Urogenital Abnormalities | Valproic Acid | 3.08 | 8888407 | |
| MESH:D014565 | Urogenital Neoplasms | Curcumin | 3.67 | 18462866 | |
| MESH:D014570 | Urologic Diseases | cypermethrin | 11.54 | 16487989 | |
| MESH:D014570 | Urologic Diseases | DDT | 11.54 | 16487989 | |
| MESH:D014570 | Urologic Diseases | Dichlorodiphenyl Dichloroethylene | 11.54 | 16487989 | |
| MESH:D014581 | Urticaria | Acetaminophen | 4.39 | 10982225 | |
| MESH:D014581 | Urticaria | Loratadine | 4.39 | 2568013 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Diethylstilbestrol | 14.55 | 16175088 | |
| MESH:D002583 | Uterine Cervical Neoplasms | indole-3-carbinol | 14.55 | 16082211 | |
| MESH:D002583 | Uterine Cervical Neoplasms | resveratrol | 14.55 | 17473185 | |
| MESH:D002583 | Uterine Cervical Neoplasms | sodium arsenite | 14.55 | 11813266 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Tretinoin | 14.55 | 16129372 | |
| MESH:D014591 | Uterine Diseases | bisphenol A | 8.49 | 14652134 | |
| MESH:D014591 | Uterine Diseases | Diethylstilbestrol | 8.49 | 14652134 | |
| MESH:D014594 | Uterine Neoplasms | Captan | 14.25 | 8441825 | |
| MESH:D014594 | Uterine Neoplasms | Diethylstilbestrol | 14.25 | 15809267 16690809 | |
| MESH:D014594 | Uterine Neoplasms | Ethinyl Estradiol | 14.25 | 14692618 | |
| MESH:D014594 | Uterine Neoplasms | resveratrol | 14.25 | 17044934 | |
| MESH:D014594 | Uterine Neoplasms | sulindac sulfide | 14.25 | 18645019 | |
| MESH:D014604 | Uveal Neoplasms | decitabine | 7.51 | 17785578 | |
| MESH:D014604 | Uveal Neoplasms | Tretinoin | 7.51 | 16752155 | |
| MESH:D014605 | Uveitis | Dexamethasone | 3.22 | 1336536 | |
| MESH:D014625 | Vaginal Neoplasms | Diethylstilbestrol | 2.90 | 16002989 16513791 | |
| MESH:D014652 | Vascular Diseases | Arsenic | 6.61 | 17056641 | |
| MESH:D014652 | Vascular Diseases | sodium arsenite | 6.61 | 17056641 | |
| MESH:D054079 | Vascular Malformations | Tetrachlorodibenzodioxin | 2.98 | 12125929 | |
| MESH:D054556 | Venous Thromboembolism | Raloxifene | 3.60 | 16837676 | |
| MESH:D020246 | Venous Thrombosis | Ethinyl Estradiol | 2.07 | 14671159 15869587 | |
| MESH:D018487 | Ventricular Dysfunction, Left | Doxorubicin | 8.37 | 16364871 17334414 17638931 17678736 | |
| MESH:D018487 | Ventricular Dysfunction, Left | Plant Extracts | 8.37 | 18097624 | |
| MESH:D018487 | Ventricular Dysfunction, Left | resveratrol | 8.37 | 17488730 | |
| MESH:D020257 | Ventricular Remodeling | Plant Extracts | 3.73 | 18097624 | |
| MESH:D014802 | Vitamin A Deficiency | Vitamin A | 3.76 | 16175781 16960172 16146918 | |
| MESH:D014820 | Vitiligo | Tretinoin | 2.54 | 16761959 | |
| MESH:D014846 | Vulvar Neoplasms | Raloxifene | 3.94 | 16343187 | |
| MESH:D019282 | Wasting Syndrome | Tetrachlorodibenzodioxin | 2.64 | 15886252 | |
| MESH:D009396 | Wilms Tumor | Tretinoin | 2.53 | 16287080 | |
| MESH:D014947 | Wounds and Injuries | Drugs, Chinese Herbal | 6.52 | 16313111 | |
| MESH:D014947 | Wounds and Injuries | Estrogens | 6.52 | 11172683 | |
| MESH:D014947 | Wounds and Injuries | Plant Extracts | 6.52 | 20213670 19894650 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04961 | Endocrine and other factor-regulated calcium reabsorption |
| REACT:71 | Gene Expression |
| Releated gene ID | Related gene Name |
|---|---|
| PA24583 | ADORA1 |
| PA33856 | PSEN2 |
| PA27844 | ERBB2 |
| Releated disease ID | Related disease Name |
|---|---|
| PA445857 | Thyroid Neoplasms |
| PA445190 | Osteoporosis |
| PA443890 | Diabetes Mellitus, Type 2 |
| PA443539 | Bone Resorption |
| PA443708 | Cholestasis, Intrahepatic |
| PA443560 | Breast Neoplasms |
| PA445204 | Ovarian Neoplasms |
| PA443536 | Bone Diseases, Metabolic |
| PA445019 | Myocardial Infarction |
| PA443324 | Amenorrhea |
| PA443796 | Coronary Artery Disease |
| PA446852 | Hot Flashes |
| PA444517 | Hyperlipoproteinemia Type II |
| PA443319 | Alzheimer Disease |
| PA446411 | Endometrial Neoplasms |
| PA444039 | Endometrial Hyperplasia |
| PA162370415 | metabolic syndrome |
| Releated drug ID | Related drug Name |
|---|---|
| PA164747170 | fulvestrant |
| PA152241907 | lapatinib |
| PA451743 | trastuzumab |
| PA449503 | estradiol |
| PA448478 | l-arginine |
| PA450635 | nitric oxide |
| PA164768822 | chlorotrianisene |
| PA164754789 | conjugated estrogens |
| PA164745534 | dienestrol |
| PA449307 | diethylstilbestrol |
| PA449503 | estradiol |
| PA449509 | estrogens |
| PA449512 | estrone |
| PA449527 | ethinyl estradiol |
| PA451581 | tamoxifen |
| PA450500 | mifepristone |
| PA449509 | estrogens |
| Drugbank ID | Action | Drug Name | Description |
|---|---|---|---|
| DB00255 | agonist | Diethylstilbestrol | Antineoplastic Agents, Hormonal;Carcinogens;Estrogens, Non-Steroidal |
| DB00269 | agonist | Chlorotrianisene | Antineoplastic Agents;Antineoplastic Agents, Hormonal;Estrogens, Non-Steroidal |
| DB00286 | agonist | Prempro | Estrogens |
| DB00294 | agonist | Nuvaring | Contraceptives;Contraceptive Agents, Female |
| DB00304 | agonist | Ortho-Cept 28 Day | Contraceptives, Oral, Synthetic;Progestins |
| DB00367 | other | Triquilar 28 Tab | Contraceptives;Contraceptives, Oral, Synthetic;Contraceptive Agents, Female |
| DB00396 | agonist | Synovex S | Contraceptives;Progestins |
| DB00481 | agonist | Raloxifene | Antihypocalcemic Agents;Osteoporosis Prophylactic;Selective Estrogen Receptor Modulators;Estrogen Antagonists;Bone Density Conservation Agents |
| DB00506 | agonist | Ovral 28 Tablets | Contraceptives;Contraceptives, Oral, Synthetic;Contraceptive Agents, Female |
| DB00539 | modulator | Toremifene | Antineoplastic Agents;Antineoplastic Agents, Hormonal;Selective Estrogen Receptor Modulators;Bone Density Conservation Agents |
| DB00603 | agonist | Lunelle | Contraceptives;Contraceptives, Oral, Synthetic;Progestins |
| DB00655 | agonist | Holis 98 | Antineoplastic Agents;Estrogens;Osteoporosis Prophylactic;Anti-menopausal Agents |
| DB00675 | other/unknown | Tamoxifen | Antineoplastic Agents, Hormonal;Selective Estrogen Receptor Modulators;Estrogen Antagonists;Bone Density Conservation Agents |
| DB00783 | agonist | Triquilar 21 | Anticholesteremic Agents;Estrogens;Anti-menopausal Agents |
| DB00823 | agonist | Demulen 50 (28 Day Pack) | Contraceptives, Oral, Synthetic |
| DB00882 | agonist | Clomifene | Selective Estrogen Receptor Modulators;Estrogen Antagonists;Fertility Agents, Female |
| DB00890 | agonist | Dienestrol | Estrogens, Non-Steroidal |
| DB00947 | antagonist | Fulvestrant | Antineoplastic Agents;Antineoplastic Agents, Hormonal;Estrogen Antagonists |
| DB00957 | agonist | Tri-Cyclen Tablets - 28-Day | Contraceptives;Contraceptives, Oral, Synthetic |
| DB00977 | agonist | Yasmin 28 | Estrogens |
| DB01065 | antagonist | Plenovit Melatonina | Antioxidants;Free Radical Scavengers;Anticonvulsants;Adjuvants, Immunologic;Central Nervous System Depressants |
| DB01108 | allosteric modulator | Trilostane | Antiadrenal;Anticorticosteroids |
| DB01183 | other/unknown | Naloxone | Antinarcotic Agents;Narcotic Antagonists;Depressants;Opiate Antagonists |
| DB01185 | antagonist | Fluoxymesterone | Anabolic Agents;Antineoplastic Agents, Hormonal |
| DB01196 | agonist | Estramustine | Antineoplastic Agents;Antineoplastic Agents, Hormonal;Radiation-Protective Agents;Antineoplastic Agents, Alkylating |
| DB01357 | agonist | Mestranol | Estrogens |
| DB01406 | agonist | Danazol | Estrogen Antagonists |
| DB01431 | agonist | Allylestrenol | Progestins |
| DB01645 | - | Genistein | Antineoplastic Agents;Enzyme Inhibitors;Growth Inhibitors;Anticarcinogenic Agents;Protein Kinase Inhibitors;Phytoestrogens |
| DB01943 | - | Compound 15 | |
| DB02615 | - | Compound 19 | |
| DB02634 | - | Compound 16 | |
| DB02715 | - | Compound 18 | |
| DB03742 | - | Compound 4-D | |
| DB03802 | - | 1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol | |
| DB04471 | - | 2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol | |
| DB04573 | agonist | Estriol | Estrogens |
| DB04574 | agonist | Estropipate | Hormone Replacement Agents;Estrogens |
| DB04575 | modulator | Quinestrol | Hormone Replacement Agents;Estrogens |
| DB06713 | agonist | Ortho Evra | Contraceptives;Contraceptive Agents, Female |
| DB06871 | - | 17-METHYL-17-ALPHA-DIHYDROEQUILENIN | |
| DB06898 | - | 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol | |
| DB06927 | - | [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE | |
| DB07086 | - | 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL | |
| DB07087 | - | 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL | |
| DB07195 | - | 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL | |
| DB07567 | - | (2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL | |
| DB07638 | - | (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL | |
| DB07678 | - | (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL | |
| DB07707 | - | (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL | |
| DB07708 | - | 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL | |
| DB07712 | - | 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL | |
| DB07932 | - | dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate | |
| DB07933 | - | (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL | |
| DB07991 | - | N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE | |
| DB08020 | - | (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL | |
| DB08047 | - | 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol | |
| DB08048 | - | 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL | |
| DB08320 | - | DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE | |
| DB08398 | - | 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE | |
| DB08595 | - | 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL | |
| DB08737 | - | (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL | |
| DB08773 | - | RALOXIFENE CORE |
| No data |
| No data |
| No data |