AutismKB 2.0

Annotation Detail for ALAD


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Basic Information Top
Gene Symbol:ALAD ( ALADH,MGC5057,PBGS )
Gene Full Name: aminolevulinate dehydratase
Band: 9q32
Quick LinksEntrez ID:210; OMIM: 125270; Uniprot ID:HEM2_HUMAN; ENSEMBL ID: ENSG00000148218; HGNC ID: 395
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5920heme biosynthesis II
PWY-5189tetrapyrrole biosynthesis II
Pathway IDPathway Name
hsa00860Porphyrin and chlorophyll metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of porphyrins
No data
Pathway IDPathway Name
P02746Heme biosynthesis
Pathway IDPathway Name
500860Heme biosynthesis
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of cofactor/vitamin metabolism
H00202Hepatic porphyria
Genetic disorders
Desease IDDesease Name
1904Diabetes mellitus
1950Parasitic disease
2007Liver tumor
2022Liver cancer
2136Hypothyroidism
Desease Name
lead toxicity
zinc
METABOLIC
lead blood levels
No data
Desease Name
Lead poisoning, susceptibility to
Porphyria, acute hepatic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ALAD mRNAdecreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ALAD mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ALAD mRNAdecreases expression 18648102
C001969 acephate acephate results in decreased activity of ALAD proteindecreases activity 8687997
D000082 Acetaminophen Acetaminophen affects the expression of ALAD mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen affects the expression of ALAD proteinaffects expression 16687475
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ALAD proteinaffects expression 20106945
D000622 Aminolevulinic Acid ALAD protein results in increased metabolism of Aminolevulinic Acidincreases metabolic processing 8687997
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ALAD mRNAaffects expression 16483693
D001374 Azacitidine Azacitidine results in decreased expression of ALAD mRNAdecreases expression 19194470
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ALAD mRNAdecreases expression 15336504
D002104 Cadmium Cadmium results in decreased activity of ALAD proteindecreases activity 8687997
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ALAD mRNAdecreases expression 17484886
D002330 Carmustine Carmustine results in decreased expression of ALAD mRNAdecreases expression 15980968
D003300 Copper Copper results in decreased activity of ALAD proteindecreases activity 19888908
D016572 Cyclosporine Cyclosporine results in decreased expression of ALAD mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of ALAD mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of ALAD mRNAdecreases expression 19638242
D004958 Estradiol Estradiol affects the expression of ALAD mRNAaffects expression 16684588
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ALAD mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ALAD mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALAD mRNAaffects cotreatment|increases expression 17942748
D006581 Hexachlorobenzene Hexachlorobenzene affects the expression of ALAD mRNAaffects expression 15159207
D007854 Lead ALAD gene polymorphism affects the susceptibility to Leadaffects response to substance 16487505
D007854 Lead ALAD gene SNP affects the abundance of Leadaffects abundance 16341691
D007854 Lead ALAD gene SNP results in increased susceptibility to Leadincreases response to substance 16341691
D008300 Maleic Hydrazide Maleic Hydrazide results in decreased activity of ALAD proteindecreases activity 8687997
C014655 methamidophos methamidophos results in decreased activity of ALAD proteindecreases activity 8687997
C008493 methylselenic acid methylselenic acid results in increased expression of ALAD mRNAincreases expression 18548127
D009538 Nicotine Nicotine results in decreased activity of ALAD proteindecreases activity 8687997
C041786 palm oil palm oil results in increased expression of ALAD mRNAincreases expression 18042831
D010269 Paraquat Paraquat results in decreased activity of ALAD proteindecreases activity 12180188
D010575 Pesticides Pesticides results in decreased activity of ALAD proteindecreases activity 15922524
D013629 Tamoxifen Tamoxifen affects the expression of ALAD mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALAD mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ALAD mRNAdecreases expression 18163543
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ALAD mRNAincreases expression 17942748
D019772 Topotecan ALAD protein affects the susceptibility to Topotecanaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2618287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6417505938
MESH:D000230 Adenocarcinoma Estradiol 3.9511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.9514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.103712494
MESH:D000236 Adenoma Diethylnitrosamine 6.1010737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.0718056438 19061943 17620307 19052882 17162532 16434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.0716835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 8.4511874814
MESH:D000382 Agricultural Workers' Diseases Pesticides 8.4517119214
MESH:D000544 Alzheimer Disease Copper 4.7017119284 16886094 16410023 16866297 16325427 16962711
MESH:D000544 Alzheimer Disease Nicotine 4.7016627626
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 4.1110694572
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6911748828
MESH:D018798 Anemia, Iron-Deficiency Copper 4.6216614410
MESH:D000799 Angioedema Acetaminophen 3.5410982225
MESH:D001161 Arteriosclerosis Dietary Fats 8.9515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4815885639
MESH:D050197 Atherosclerosis Cadmium 3.4715687053
MESH:D001289 Attention Deficit Disorder with Hyperactivity Pesticides 5.2720478945
MESH:D001321 Autistic Disorder Acetaminophen 2.6318445737
MESH:D001321 Autistic Disorder Pesticides 2.6317938740
MESH:D001342 Autonomic Nervous System Diseases methamidophos 6.4811527224
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.721440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5815746008
MESH:D001932 Brain Neoplasms Carmustine 8.5616187019
MESH:D001932 Brain Neoplasms Copper 8.5617079463
MESH:D001943 Breast Neoplasms Copper 3.5717079463 15986119
MESH:D001943 Breast Neoplasms Dietary Fats 3.5720435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.5717474063
MESH:D001943 Breast Neoplasms Estradiol 3.5718497071 12948864 17289903 16675129 17018787 17261762 19861407 14630087
MESH:D001943 Breast Neoplasms Hexachlorobenzene 3.5715061365 12709520
MESH:D001943 Breast Neoplasms Tamoxifen 3.5716873071 18629630 19084267 19142967 17261762 16818667 19487384 19103187 19221464 18821012 17440819 18855134 21152245 19066611 17049068 19289846 19189212 20065188 20390343 18425577 19059307 20005174 19200415 16202921 18815881 18997820 19011961 18984771 20859285 19244106 17242785 11161223 19288272 19115204 21138602 20135344 19410462 19155303 19189210 15668708 16273361 15565566 17893378 18351453 20544844
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.5720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4916227642 16011737 15721981 16097048 15700767 16124888 15673190 18705752 16192424 10355542 3786805 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5716835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2219066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.0116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 16.017296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.013084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.0121507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.0118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.0110672840 20935162 16935385 19394651 20514400 17428255 16698587 19519916 18978308 17173139 17055752 19171122 19208518 17761372 16569478 17138121 19701751 19539802 16328049 18210153 20214788 11831363 20727157 18785209 18506893 17978847 16540662 3084413 19919837 16288022 16878318 16807293 16830150 20084675 18788625 18393292 16502159 19052882 18691550 16681979 19335982 3581430 18056438 18494052 20432363 19107877 19383236 20101231 20524982 17162532 20007298 19822196 16779866 20512989 19418558 10737359 21159647 18665156 18971187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.0116924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 16.0116924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.547296757
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3617572228
MESH:D006332 Cardiomegaly Copper 6.5117327471
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.5116120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.4110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 23.746135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 23.747505956
MESH:D002471 Cell Transformation, Neoplastic Cadmium 23.7417332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 23.7412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 23.742727394 7505956 21159647 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 23.7418566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5016835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.1319486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.1319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.1317681005 16919318 17110522 15861022 17333356 11677210 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9815668235 8697196 12621046 16354765 15340226
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8114669216 17141729
MESH:D019465 Craniofacial Abnormalities Lead 2.9019769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.9020055451 10048152 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.7318551238
MESH:D003704 Dementia Lead 4.9916140633
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0719031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.538156756 11298694 14531868 8970840 2524372 18759878 11906362 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.222952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.9620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9617107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.0219279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.0219279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 14.0418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.041440618 6679447 16192314 9328219 9022650 8291058 7440962 18289764 6482804 9653073 11289319 18648102 18692083
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.0412705907 12594235 11421492 19370779 16081117 17562736 17522070 15968718 16177239 12392966 16781746 19420014 16227642 19164858 14725611 16485898 11834606 10774834 19085960 16393943 18071297 11739529 11461765 19739265 14986274 17906064 19416960 19923254 16109766 10663392 12958197 14550746 11287661 18713872 12540782 11743745 12153990 2444490 11529661 10915739 15619225
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.0419085960 15998439 15968718 9327722 10915739 10092053 16177239 6884620 17522070 3786805 7440962 3732212 7179309 4309450 21278145 11566570 2869522 6623471 15027814 16227642 7120509 19336974
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 14.0419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.0420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5511462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2418367378
MESH:D020821 Dystonic Disorders Nicotine 5.6317881519
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.1312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.0112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.0119031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.7519148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.7517893378 16202921 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7710568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8216302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.033581430
MESH:D020329 Essential Tremor Lead 5.6318007985 14594619
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8011564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 27.2815959796 12631006 17595544 16045604 19224547 12795759 61145 16239168
MESH:D005234 Fatty Liver Cyclosporine 27.2819224547
MESH:D005234 Fatty Liver Dietary Fats 27.2818296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 27.2821071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.2815345470
MESH:D005234 Fatty Liver Tamoxifen 27.2814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0616709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D005317 Fetal Growth Retardation Lead 5.2619769572
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.726705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2314745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8919069698
MESH:D005355 Fibrosis Carbon Tetrachloride 18.7518705752
MESH:D005355 Fibrosis Cyclosporine 18.7512168785 12639820
MESH:D005355 Fibrosis Dietary Fats 18.7518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.7520067830
MESH:D005517 Foodborne Diseases methamidophos 6.8411527224
MESH:D005756 Gastritis Acetaminophen 3.3816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.928708960
MESH:D005909 Glioblastoma Carmustine 3.7416187019
MESH:D005911 Gliosis Paraquat 4.8611124998
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.767505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1811294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.296705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.2919900420 19110552
MESH:D006521 Hepatitis, Chronic Copper 4.9817338147
MESH:D006527 Hepatolenticular Degeneration Copper 4.8817276780 16607473 17109627 19888908 17182432
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6112621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D019584 Hot Flashes Estradiol 3.4517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7516354765 18606429 16959395 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.4716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2416899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.3421332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6515034207
MESH:D006973 Hypertension Cyclosporine 4.5610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.5618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 14.6117937319
MESH:D007248 Infertility, Male Lead 14.6116780224
MESH:D007248 Infertility, Male methamidophos 14.6110828210
MESH:D007248 Infertility, Male Paraquat 14.614850670
MESH:D007249 Inflammation Dietary Fats 10.6620412841
MESH:D007249 Inflammation Diethylnitrosamine 10.6618785209
MESH:D007249 Inflammation Tamoxifen 10.6619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.6612878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 6.7318457598 11836018
MESH:D007333 Insulin Resistance Estradiol 6.7316393666 16627594
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.729022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0716580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1415604871
MESH:D007674 Kidney Diseases Acetaminophen 13.0515629191 12587719
MESH:D007674 Kidney Diseases Cadmium 13.0516962696 16322080 16226777
MESH:D007674 Kidney Diseases Cyclosporine 13.0510903974 8314463 18776723
MESH:D007674 Kidney Diseases Estradiol 13.0515618244
MESH:D007676 Kidney Failure, Chronic Copper 4.6316518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 20.8016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 20.806582329
MESH:D007680 Kidney Neoplasms Cyclosporine 20.8012371664
MESH:D007680 Kidney Neoplasms Estradiol 20.8015610895
MESH:D007680 Kidney Neoplasms Tamoxifen 20.8018625569
MESH:D007855 Lead Poisoning Lead 5.6316700817
MESH:D007859 Learning Disorders Copper 9.4517134702
MESH:D007859 Learning Disorders Lead 9.4516384672
MESH:D007938 Leukemia Azacitidine 3.5519148494
MESH:D007951 Leukemia, Myeloid Azacitidine 4.3619077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 2.9517596541 18720364
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.9219299654
MESH:D008064 Lipidoses Tamoxifen 2.9515342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.0711903743 16943688 17157831 17334410 21278145 11408273 16221502 16239168 17174718
MESH:D008103 Liver Cirrhosis Dietary Fats 10.0718296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.0719638242 18407596 18665156 20032147 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.019327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.6112898905 16027843 15338365 15052691 17766677 18279442 18412020 17721639 18187930 10355542 17761835 17944888 18376398 15057751 15818738 18705752 17631135 18420326 15730626 16033810 18210741 18205269 15931870 18395095 15362042 13678700 12632514 12609069 16638106 16097048 18395914 11481614 18251166 17900296 17805973 15876570 15123356 14716833 15996030 12445421 16192424 17640975 15673190 18166357 16248980 12667390 12632512 14724832 18339082 17525996 17922224 18481824 17708605 18418968 12546737 20821823 12958196 18156304 12741479 18429990 12586293 18054572 17557913 15893842 17714472 17698563 12649538 15959796 18277467 12389079 14620537 16011737 12445418 18263696 14716496 17823541 18317297 18472332 15650968 16116963 15370692 17565644 15925388 18006644 17869086 14748882 17481882 17976157 18472094 16015684 12666154 14512876 16136751
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.6114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.6118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.6112878042
MESH:D008107 Liver Diseases Acetaminophen 5.9919460945 16611625 12969438 19784758 19014921 16610002 11587558 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.9915830285 16246199 17285989 16964402 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 5.9917034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.5617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.5616899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 20.127678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.1218177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.1219294768
MESH:D008113 Liver Neoplasms Copper 20.1220302851
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.122422723 21278145 19427195 15175105 15885732 21167192 19833225 18648771 18978307 19426721 20118626 18977376 20501860 19996281 16942905 19254457 19551842 20583210 19073162 21071580 19850985 19638242 21047994 19499222 20434301 20101389 19090486 19294768 19690152 19255062 18754104 19642983 20137499 2862719 9163691 12771043 19256749 19812893 20492335 10737359 20452335 12112319 18644402 20405173
MESH:D008113 Liver Neoplasms Tamoxifen 20.1216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.1216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 25.452876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 25.451399818 6587162 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 25.458603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 25.4515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 25.4518775883 19004024 18544905 18253720 17942915 18164116 18079962 21159647 18282651 17174075 19519916 19126423 18308698 18093689 16842330 2563599 19009564 3124819 9362446 17854601 16267830 19539802
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 25.451423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.4512151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.1814755239
MESH:D008175 Lung Neoplasms Azacitidine 6.1821224363
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.1820970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 6.1818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.1811884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.3511807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.3511731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.6519453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.6519453300
MESH:D008545 Melanoma Carmustine 3.4512393984
MESH:D008545 Melanoma Tamoxifen 3.4512393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2819513568
MESH:D008569 Memory Disorders Lead 4.8816384672 17263510
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.5817109627 17268249
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4916801185
MESH:D009006 Monosomy Azacitidine 5.7819299654
MESH:D009101 Multiple Myeloma Azacitidine 3.7618443271 19549372
MESH:D018908 Muscle Weakness methamidophos 6.4817849254
MESH:D009190 Myelodysplastic Syndromes Azacitidine 3.8317611569 19805378 17596541 18720364
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0616810080
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.577678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.753581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.753581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.7519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4219410462
MESH:D009369 Neoplasms Nicotine 3.4116365874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7019200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Copper 15.4817308104
MESH:D009389 Neovascularization, Pathologic Estradiol 15.4817289903
MESH:D009389 Neovascularization, Pathologic Nicotine 15.4816365874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0418481113 19348381
MESH:D009410 Nerve Degeneration Paraquat 3.4916893418
MESH:D009422 Nervous System Diseases methamidophos 5.3915938848 2238440
MESH:D009421 Nervous System Malformations Estradiol 8.5311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.5314600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.726679447
MESH:D009447 Neuroblastoma Topotecan 3.7015176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.3918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.3920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8220387270
MESH:D009765 Obesity Dietary Fats 2.2118674790 20518802 18457598 17217161 16723640 19632207 20132043 21332399 11836018
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.0416049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.046482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.723988306
MESH:D010051 Ovarian Neoplasms Estradiol 2.1319401270
MESH:D010146 Pain Acetaminophen 2.1616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3216540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.207296757
MESH:D010300 Parkinson Disease Paraquat 2.7115824117 11445065 15451049 16510128 12911755 11181820 11124998 16140633
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1416190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D010523 Peripheral Nervous System Diseases methamidophos 5.487654138 2170085 10447555
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.0915687053
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.176228378
MESH:D011014 Pneumonia Paraquat 4.1612504350
MESH:D011041 Poisoning methamidophos 5.1416119251 17849254
MESH:D011115 Polyneuropathies methamidophos 5.797654138
OMIM:612740 PORPHYRIA, ACUTE HEPATIC marker/mechanism
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 10.179918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 10.1718163543
MESH:D011164 Porphyrias Aminolevulinic Acid 6.958937451
MESH:D011230 Precancerous Conditions Cyclosporine 8.1212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.122563599
MESH:D011297 Prenatal Exposure Delayed Effects Lead 14.9916384672
MESH:D011297 Prenatal Exposure Delayed Effects Pesticides 14.9917938740
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.9911118676 11222880 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6220887781
MESH:D011471 Prostatic Neoplasms Azacitidine 1.8918324645
MESH:D011471 Prostatic Neoplasms Cadmium 1.8917075824
MESH:D011471 Prostatic Neoplasms Copper 1.8917308104 17079463
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.8916205645
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.0216919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8016324872 17997886
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.6411700416
MESH:D012135 Respiratory Sounds Paraquat 9.4411874814
MESH:D012135 Respiratory Sounds Pesticides 9.4417119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012140 Respiratory Tract Diseases Pesticides 5.8617119214
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.193692021
MESH:D012162 Retinal Degeneration Paraquat 8.1916458197
MESH:D012559 Schizophrenia Copper 3.0416842975
MESH:D012640 Seizures 2,6-dinitrotoluene 5.6818551238
MESH:D012640 Seizures Nicotine 5.6817873105
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.128532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.5616709447
MESH:D013088 Spermatocele Tamoxifen 10.5616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7419457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.381399818 6582329 3712494 7505956 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.387505956
MESH:D013978 Tibial Fractures Estradiol 4.3919048282
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.5216785264 16720336 11259349
MESH:D014029 Tobacco Use Disorder Nicotine 5.1618041664 18305452 17979512 15735609
MESH:D014202 Tremor Lead 5.1921145352
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.5916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 7.598074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.5916712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.0210091137
MESH:D014581 Urticaria Acetaminophen 2.7110982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0214692618
MESH:D014605 Uveitis Cyclosporine 3.681336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
MESH:D015430 Weight Gain Dietary Fats 3.4916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.1417120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:9431 Metabolism of porphyrins
KEGG:00860 Porphyrin and chlorophyll metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24687
    • No data
    No data
    Releated drug ID Related drug Name
    PA449789glycine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00855 agonist Aminolevulinic acid Photosensitizing Agents
    DB02068 - Delta-Amino Valeric Acid
    DB02239 - Laevulinic Acid Enzyme Inhibitors
    DB02260 - 4-Oxosebacic Acid
    DB02272 - Porphobilinogen
    DB02878 - 3-(2-Aminoethyl)-4-(Aminomethyl)Heptanedioic Acid
    DB03131 - Beta-Mercaptoethanol
    DB04560 - 4,7-Dioxosebacic Acid
    DB04781 - 5-hydroxyvaleric acid
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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