AutismKB 2.0

Annotation Detail for ESRRA


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Basic Information Top
Gene Symbol:ESRRA ( ERR1,ERRa,ERRalpha,ESRL1,NR3B1 )
Gene Full Name: estrogen-related receptor alpha
Band: 11q13.1
Quick LinksEntrez ID:2101; OMIM: 601998; Uniprot ID:ERR1_HUMAN; ENSEMBL ID: ENSG00000173153; HGNC ID: 3471
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Gene Expression
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1859Ovarian cancer
1944Breast cancer
2031Endometrial cancer
2220Dermatitis
Desease Name
bone density
METABOLIC
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C517943 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of ESRRA mRNAincreases expression 20211987
C517943 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of ESRRA proteinincreases expression 20211987
C517943 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone GPER protein promotes the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of ESRRA mRNA]increases expression|increases reaction 20211987
C517943 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone PD 98059 inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
C517943 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone Pertussis Toxin inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
C035476 2,2',4,4'-tetrahydroxybenzophenone 2,2',4,4'-tetrahydroxybenzophenone results in decreased expression of ESRRA mRNAdecreases expression 15458797
C035476 2,2',4,4'-tetrahydroxybenzophenone 2,2',4,4'-tetrahydroxybenzophenone results in increased expression of ESRRA mRNAincreases expression 15458797
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ESRRA mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ESRRA mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen binds to and results in decreased activity of [ESRRG protein binds to ESRRA protein]affects binding|decreases activity 14751226
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen binds to ESRRA protein mutant formaffects binding 11447273
D000082 Acetaminophen Acetaminophen affects the expression of ESRRA mRNAaffects expression 17562736
C412373 AG 1879 AG 1879 inhibits the reaction [fulvestrant results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
C412373 AG 1879 AG 1879 inhibits the reaction [Tamoxifen results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
C004541 biochanin A biochanin A binds to and results in increased activity of ESRRA proteinaffects binding|increases activity 14638870
C004541 biochanin A biochanin A binds to ESRRA protein mutant formaffects binding 14638870
C004541 biochanin A biochanin A promotes the reaction [ESRRA protein binds to PNRC1 protein]affects binding|increases reaction 14638870
C004541 biochanin A biochanin A binds to and results in increased activity of ESRRA proteinaffects binding|increases activity 16515477
D002330 Carmustine Carmustine results in increased expression of ESRRA mRNAincreases expression 15980968
D002706 Chlordan Chlordan binds to and results in decreased activity of ESRRA proteinaffects binding|decreases activity 11850205
15955695
D002706 Chlordan Chlordan results in decreased activity of ESRRA proteindecreases activity 10493499
D002706 Chlordan Chlordan binds to and results in decreased activity of ESRRA proteinaffects binding|decreases activity 16515477
D002976 Clenbuterol Clenbuterol results in increased expression of ESRRA mRNAincreases expression 17446185
C004742 daidzein daidzein binds to and results in increased activity of ESRRA proteinaffects binding|increases activity 14638870
C004742 daidzein daidzein binds to and results in increased activity of ESRRA protein mutant formaffects binding|increases activity 14638870
C004742 daidzein daidzein promotes the reaction [ESRRA protein binds to PNRC1 protein]affects binding|increases reaction 14638870
C004742 daidzein daidzein binds to and results in increased activity of ESRRA proteinaffects binding|increases activity 16515477
D004054 Diethylstilbestrol Diethylstilbestrol binds to and results in decreased activity of ESRRA proteinaffects binding|decreases activity 11559547
D004054 Diethylstilbestrol Diethylstilbestrol inhibits the reaction [ESRRA protein results in increased expression of TFF1 mRNA]decreases reaction|increases expression 11559547
D004054 Diethylstilbestrol Diethylstilbestrol binds to and results in decreased activity of ESRRA proteinaffects binding|decreases activity 16515477
D004958 Estradiol Estradiol results in decreased expression of ESRRA mRNAdecreases expression 15968320
D004958 Estradiol Estradiol results in increased expression of ESRRA mRNAincreases expression 15223131
20211987
D004958 Estradiol Estradiol results in increased expression of ESRRA proteinincreases expression 20211987
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in decreased expression of ESRRA mRNA]decreases expression|decreases reaction 15968320
D004958 Estradiol GPER protein promotes the reaction [Estradiol results in increased expression of ESRRA mRNA]increases expression|increases reaction 20211987
D004958 Estradiol PD 98059 inhibits the reaction [Estradiol results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
D004958 Estradiol Pertussis Toxin inhibits the reaction [Estradiol results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
D004958 Estradiol Estradiol results in decreased expression of ESRRA mRNAdecreases expression 15458797
D004958 Estradiol Estradiol results in increased expression of ESRRA mRNAincreases expression 15458797
12193582
D004967 Estrogens Estrogens results in increased expression of ESRRAincreases expression 15821111
D004967 Estrogens Estrogens results in increased expression of ESRRA mRNAincreases expression 12960079
D004967 Estrogens Estrogens results in increased expression of ESRRAincreases expression 15821111
D004967 Estrogens Estrogens results in increased expression of ESRRA mRNAincreases expression 12960079
C043562 flavone flavone binds to and results in increased activity of ESRRA proteinaffects binding|increases activity 14638870
C043562 flavone flavone binds to ESRRA protein mutant formaffects binding 14638870
C070081 fulvestrant AG 1879 inhibits the reaction [fulvestrant results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in decreased expression of ESRRA mRNA]decreases expression|decreases reaction 15968320
C070081 fulvestrant fulvestrant promotes the reaction [SP1 protein binds to ESRRA promoter]affects binding|increases reaction 20211987
C070081 fulvestrant fulvestrant promotes the reaction [SP3 protein binds to ESRRA promoter]affects binding|increases reaction 20211987
C070081 fulvestrant fulvestrant results in increased expression of ESRRA mRNAincreases expression 20211987
C070081 fulvestrant fulvestrant results in increased expression of ESRRA proteinincreases expression 20211987
C070081 fulvestrant GPER protein promotes the reaction [fulvestrant results in increased expression of ESRRA mRNA]increases expression|increases reaction 20211987
C070081 fulvestrant PD 98059 inhibits the reaction [fulvestrant results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
C070081 fulvestrant Pertussis Toxin inhibits the reaction [fulvestrant results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
D019833 Genistein Genistein binds to and results in increased activity of ESRRA proteinaffects binding|increases activity 15955695
14638870
D019833 Genistein Genistein binds to and results in increased activity of ESRRA protein mutant formaffects binding|increases activity 14638870
D019833 Genistein Genistein binds to and results in increased activity of ESRRA proteinaffects binding|increases activity 16515477
D007529 Isoflavones Isoflavones binds to and results in increased activity of ESRRA proteinaffects binding|increases activity 14638870
D007529 Isoflavones Isoflavones binds to ESRRA protein mutant formaffects binding 14638870
C082161 lipopolysaccharide A lipopolysaccharide A inhibits the reaction [ESRRA protein binds to ACADM promoter]affects binding|decreases reaction 16061943
C082161 lipopolysaccharide A lipopolysaccharide A results in decreased expression of ESRRA mRNAdecreases expression 16061943
C005290 oxybenzone oxybenzone results in decreased expression of ESRRA mRNAdecreases expression 15458797
D010269 Paraquat Paraquat results in decreased expression of ESRRA mRNAdecreases expression 12595580
C093973 PD 98059 PD 98059 inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
C093973 PD 98059 PD 98059 inhibits the reaction [Estradiol results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
C093973 PD 98059 PD 98059 inhibits the reaction [fulvestrant results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
C093973 PD 98059 PD 98059 inhibits the reaction [Tamoxifen results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [Estradiol results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [fulvestrant results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [Tamoxifen results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
C119222 phorbol-12-myristate phorbol-12-myristate promotes the reaction [ESRRA protein binds to and results in increased expression of TFF1 mRNA]affects binding|increases expression|increases reaction 16024613
D048789 Phytoestrogens Phytoestrogens binds to and results in increased activity of ESRRA proteinaffects binding|increases activity 16515477
D011374 Progesterone Progesterone results in increased expression of ESRRA mRNAincreases expression 15968320
D013629 Tamoxifen AG 1879 inhibits the reaction [Tamoxifen results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
D013629 Tamoxifen GPER protein promotes the reaction [Tamoxifen results in increased expression of ESRRA mRNA]increases expression|increases reaction 20211987
D013629 Tamoxifen PD 98059 inhibits the reaction [Tamoxifen results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
D013629 Tamoxifen Pertussis Toxin inhibits the reaction [Tamoxifen results in increased expression of ESRRA mRNA]decreases reaction|increases expression 20211987
D013629 Tamoxifen Tamoxifen promotes the reaction [SP1 protein binds to ESRRA promoter]affects binding|increases reaction 20211987
D013629 Tamoxifen Tamoxifen promotes the reaction [SP3 protein binds to ESRRA promoter]affects binding|increases reaction 20211987
D013629 Tamoxifen Tamoxifen results in increased expression of ESRRA mRNAincreases expression 20211987
D013629 Tamoxifen Tamoxifen results in increased expression of ESRRA proteinincreases expression 20211987
D014112 Toxaphene Toxaphene binds to and results in decreased activity of ESRRA proteinaffects binding|decreases activity 11356845
11850205
15955695
D014112 Toxaphene Toxaphene binds to and results in increased activity of ESRRA protein mutant formaffects binding|increases activity 11356845
D014112 Toxaphene Toxaphene inhibits the reaction [NCOA2 protein results in increased activity of ESRRA protein]decreases reaction|increases activity 10493499
D014112 Toxaphene Toxaphene results in decreased activity of ESRRA proteindecreases activity 10493499
D014112 Toxaphene Toxaphene binds to and results in decreased activity of ESRRA proteinaffects binding|decreases activity 16515477
C012589 trichostatin A trichostatin A results in increased activity of ESRRA proteinincreases activity 11705994
D014425 Turpentine Turpentine results in decreased expression of ESRRA mRNAdecreases expression 16061943
C488234 XCT790 XCT790 results in decreased expression of ESRRA proteindecreases expression 19464277
C488234 XCT790 XCT790 binds to and affects the activity of ESRRA proteinaffects activity|affects binding 19464277
C488234 XCT790 XCT790 binds to and results in decreased activity of ESRRA proteinaffects binding|decreases activity 16515477
D015054 Zymosan Zymosan results in decreased expression of ESRRA mRNAdecreases expression 16061943
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2214745880
MESH:D000210 Acute-Phase Reaction Turpentine 5.8516044259
MESH:D000230 Adenocarcinoma daidzein 6.7611473722
MESH:D000230 Adenocarcinoma Estradiol 6.7611473722
MESH:D000230 Adenocarcinoma Genistein 6.7611473722
MESH:D000382 Agricultural Workers' Diseases Paraquat 8.2211874814
MESH:D000382 Agricultural Workers' Diseases Toxaphene 8.2216132792
MESH:D000505 Alopecia Isoflavones 4.4617569567
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1715469931
MESH:D000740 Anemia Zymosan 4.2818664788
MESH:D000799 Angioedema Acetaminophen 3.5110982225
MESH:D001169 Arthritis, Experimental Zymosan 3.9215188379 15142272 15944321 16872482 17659584
MESH:D001284 Atrophy fulvestrant 4.5411514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0117868700
MESH:D001930 Brain Injuries Progesterone 3.9415665606 15845082 15380490
MESH:D001932 Brain Neoplasms Carmustine 4.1116187019
MESH:D001943 Breast Neoplasms marker/mechanism 20961995
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.5515324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 3.5517289903 18497071 17261762 17018787 19861407 12948864 14630087 16675129
MESH:D001943 Breast Neoplasms fulvestrant 3.5518984771
MESH:D001943 Breast Neoplasms Genistein 3.5517200150 16873071 16541309
MESH:D001943 Breast Neoplasms Phytoestrogens 3.5517158751 17176212
MESH:D001943 Breast Neoplasms Progesterone 3.5516175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 3.5516202921 17440819 18629630 16873071 16818667 19200415 19155303 21152245 18351453 19115204 18855134 18984771 15668708 17049068 20544844 19059307 17893378 20859285 19189210 21138602 19011961 18425577 18997820 19289846 20135344 19288272 20065188 17242785 19221464 17261762 11161223 16273361 18815881 19103187 19189212 19410462 19084267 20390343 18821012 19487384 19142967 20005174 15565566 19066611 19244106
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1416111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1919066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 15.8916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 15.8916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.893084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 15.8916924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.8916924424
MESH:D006528 Carcinoma, Hepatocellular Estrogens 15.8915341023
MESH:D006528 Carcinoma, Hepatocellular Genistein 15.8916924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 15.8916924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3317572228
MESH:D002318 Cardiovascular Diseases daidzein 15.6716332659
MESH:D002318 Cardiovascular Diseases Genistein 15.6716332659
MESH:D002318 Cardiovascular Diseases Isoflavones 15.6717689850
MESH:D002318 Cardiovascular Diseases Phytoestrogens 15.6716862667
MESH:D002386 Cataract Acetaminophen 2.3910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 5.936135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.9318566989
MESH:D003110 Colonic Neoplasms Genistein 2.2317182828
MESH:D015179 Colorectal Neoplasms Isoflavones 2.9017116718
MESH:D003327 Coronary Disease Phytoestrogens 4.9917367797
MESH:D016638 Critical Illness Estrogens 5.6216670151
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.2516002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.8318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.8318551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0419031437
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 4.6916647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.6916647724
MESH:D003928 Diabetic Nephropathies Estradiol 7.9419279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.9419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1717187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 5.5718551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 5.5718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.5712705907 19164858 14725611 19085960 18713872 19739265 10663392 12594235 16781746 11461765 12540782 14986274 12392966 10915739 11739529 17906064 12153990 16227642 19923254 11421492 11743745 19416960 15619225 16177239 10774834 17522070 2444490 15968718 14550746 18071297 16485898 16081117 17562736 11834606 11529661 11287661 19370779 12958197 16393943 16109766 19420014
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7719426721
MESH:D004487 Edema Zymosan 3.717907874
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.1417692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.1419031437
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 5.3119294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 18.4816402032
MESH:D004714 Endometrial Hyperplasia Genistein 18.4816402032
MESH:D004714 Endometrial Hyperplasia Phytoestrogens 18.4816402032
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 31.8119148513
MESH:D016889 Endometrial Neoplasms daidzein 31.8111473722
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 31.8116804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 31.8111473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 31.8111473722
MESH:D016889 Endometrial Neoplasms Phytoestrogens 31.8116543667
MESH:D016889 Endometrial Neoplasms Tamoxifen 31.8116202921 20544844 17893378 19155303
MESH:D004715 Endometriosis Progesterone 3.4916134523
MESH:D007172 Erectile Dysfunction daidzein 4.7114972507
MESH:D005234 Fatty Liver Tamoxifen 2.8819224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.5515751030 16534752 16513791 16611131 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.5516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8619069698
MESH:D005756 Gastritis Acetaminophen 3.3416983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.6216452187
MESH:D005909 Glioblastoma biochanin A 15.3516598420
MESH:D005909 Glioblastoma Carmustine 15.3516187019
MESH:D005909 Glioblastoma Genistein 15.3516598420
MESH:D005909 Glioblastoma trichostatin A 15.3518801729
MESH:D005911 Gliosis Paraquat 4.8311124998
MESH:D006505 Hepatitis Zymosan 4.3919110552
MESH:D006558 Herpes Genitalis Estradiol 4.7015709030
MESH:D019584 Hot Flashes Estradiol 9.3217088409
MESH:D019584 Hot Flashes Isoflavones 9.3214716179 17290160
MESH:D006930 Hyperalgesia Acetaminophen 2.4516870215
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1212960047 14722030
MESH:D006973 Hypertension daidzein 3.5517169123
MESH:D007021 Hypospadias Diethylstilbestrol 4.2616002989
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0815869954
MESH:D007246 Infertility Diethylstilbestrol 4.0515036965
MESH:D007248 Infertility, Male Chlordan 14.519432128
MESH:D007248 Infertility, Male fulvestrant 14.5111514358
MESH:D007248 Infertility, Male Paraquat 14.514850670
MESH:D007248 Infertility, Male Phytoestrogens 14.5116731787
MESH:D007249 Inflammation Progesterone 7.5115869954
MESH:D007249 Inflammation Tamoxifen 7.5119457130
MESH:D007249 Inflammation Zymosan 7.518014878 11289658
MESH:D007333 Insulin Resistance Estradiol 2.7616393666 16627594
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.5117553498
MESH:D007674 Kidney Diseases Acetaminophen 5.2615629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.2615618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 20.5516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 20.5516705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 20.5516762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 20.5515610895
MESH:D007680 Kidney Neoplasms Tamoxifen 20.5518625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7517184923
MESH:D007938 Leukemia Genistein 2.8617468513 18980019
MESH:D007945 Leukemia, Lymphoid Toxaphene 5.9616132792
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 4.9016972261
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 2.8518206229
MESH:D008064 Lipidoses Tamoxifen 2.9315342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.3117823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.3118564211
MESH:D008107 Liver Diseases Acetaminophen 1.5516611625 12969438 19460945 19014921 12587719 19784758 11587558 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9617185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 12.957678174
MESH:D008113 Liver Neoplasms Chlordan 12.952422723
MESH:D008113 Liver Neoplasms Diethylstilbestrol 12.9515890375 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 12.9516684651
MESH:D008113 Liver Neoplasms XCT790 12.9519464277
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.356135515 2876786 2876784
MESH:D008175 Lung Neoplasms Tamoxifen 1.7318625569
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8215166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.2415700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.1816002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4419428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.5611408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.5612929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.5617203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.5619196723 14580682 19196722 11731420 16827153
MESH:D020149 Manganese Poisoning Estradiol 11.5419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.5419453300
MESH:D008545 Melanoma Carmustine 4.9512393984
MESH:D008545 Melanoma Tamoxifen 4.9512393984 19393235
MESH:D008545 Melanoma trichostatin A 4.9516505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2519513568
MESH:D008659 Metabolic Diseases therapeutic 16515477
MESH:D008881 Migraine Disorders Phytoestrogens 4.7612224599
MESH:D009101 Multiple Myeloma trichostatin A 3.6418172295
MESH:D009102 Multiple Organ Failure Zymosan 4.9112130978 10479408 15241586 15259001 18160304 15213630 17724436 12879239 15834315 10890648
MESH:D009203 Myocardial Infarction Genistein 2.7217141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.6916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.6917141266
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.2618551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.267678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4119410462
MESH:D009369 Neoplasms Diethylstilbestrol 5.3515313581
MESH:D009369 Neoplasms Toxaphene 5.358820588
MESH:D009376 Neoplasms, Hormone-Dependent Phytoestrogens 10.2516912569
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.2519196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4117289903
MESH:D009410 Nerve Degeneration Paraquat 3.4716893418
MESH:D009421 Nervous System Malformations Diethylstilbestrol 14.7011399458
MESH:D009421 Nervous System Malformations Estradiol 14.7016427766 11399458
MESH:D009421 Nervous System Malformations Genistein 14.7016427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6118514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.9512819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.9516049721
MESH:D010024 Osteoporosis Genistein 6.9219401787
MESH:D010024 Osteoporosis Isoflavones 6.9216562857
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.7916169203
MESH:D010051 Ovarian Neoplasms Estradiol 10.4419401270
MESH:D010051 Ovarian Neoplasms Genistein 10.4419005980
MESH:D010051 Ovarian Neoplasms Progesterone 10.4417393432 16525653
MESH:D010051 Ovarian Neoplasms trichostatin A 10.4419331143
MESH:D010146 Pain Acetaminophen 2.1416870215
MESH:D010190 Pancreatic Neoplasms trichostatin A 3.1719294695
MESH:D010195 Pancreatitis Phytoestrogens 4.9417269527
MESH:D010300 Parkinson Disease Paraquat 2.6915824117 12911755 11181820 11445065 16140633 15451049 11124998 16510128
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1116190885
MESH:D010538 Peritonitis Zymosan 4.5717371808 18977430 18557954 15979727 17826846 18760300 15259001 14761945 19641140 11985352 19088179
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3515687265 16977796
MESH:D011014 Pneumonia Paraquat 4.1312504350
MESH:D011248 Pregnancy Complications Toxaphene 5.542087686
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 3.7917184923
MESH:D055728 Primary Myelofibrosis trichostatin A 4.9317616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5920887781
MESH:D011471 Prostatic Neoplasms biochanin A 2.3812111696
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.3817136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 2.3816740699
MESH:D011471 Prostatic Neoplasms Genistein 2.3815378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms Isoflavones 2.3817374662 17571952 16365062 17219775
MESH:D011471 Prostatic Neoplasms Phytoestrogens 2.3816921512
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.3815067354
MESH:D011471 Prostatic Neoplasms trichostatin A 2.3819789329 18798265
MESH:D011658 Pulmonary Fibrosis Paraquat 2.7916324872 17997886
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.6111700416
MESH:D012135 Respiratory Sounds Paraquat 3.7411874814
MESH:D012162 Retinal Degeneration Paraquat 3.6316458197
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7418045962
MESH:D012640 Seizures 2,4-dinitrotoluene 5.1418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.1418551238
MESH:D018805 Sepsis Zymosan 4.3811441115
MESH:D013088 Spermatocele Diethylstilbestrol 10.7416709447 16002989
MESH:D013088 Spermatocele Tamoxifen 10.7416709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.7916503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.7919457130
MESH:D013978 Tibial Fractures Estradiol 4.3519048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 10.8316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 10.8316049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 10.8316452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 10.8316712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.9010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.9010091137
MESH:D014581 Urticaria Acetaminophen 2.6810982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.7516175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.8414652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.7615809267 16690809
MESH:D014605 Uveitis Zymosan 5.0711006244
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1216002989 16513791
MESH:D014947 Wounds and Injuries Estrogens 4.4811172683
Pathway ID Pathway Name
REACT:71 Gene Expression
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27887
    • No data
    Releated disease ID Related disease Name
    PA445131Obesity
    Releated drug ID Related drug Name
    PA449750gemfibrozil
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00197 inverse agonist Troglitazone Antineoplastic Agents;Hypoglycemic Agents;Vasodilator Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents
    DB06833 - 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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