AutismKB 2.0

Annotation Detail for ESRRG


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Basic Information Top
Gene Symbol:ESRRG ( DKFZp781L1617,ERR3,ERRgamma,FLJ16023,KIAA0832,NR3B3 )
Gene Full Name: estrogen-related receptor gamma
Band: 1q41
Quick LinksEntrez ID:2104; OMIM: 602969; Uniprot ID:ERR3_HUMAN; ENSEMBL ID: ENSG00000196482; HGNC ID: 3474
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Gene Expression
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Related Diseases/Disorders Top
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Desease IDDesease Name
2031Endometrial cancer
2220Dermatitis
No data
Desease Name
Optic disc size (cup)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ESRRG mRNAincreases expression 19933214
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen binds to and affects the activity of ESRRG proteinaffects activity|affects binding 16889744
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen binds to and results in decreased activity of ESRRG proteinaffects binding|decreases activity 17049190
18197296
11447273
14751226
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen binds to and results in decreased activity of [ESRRG protein binds to ESRRA protein]affects binding|decreases activity 14751226
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen inhibits the reaction [ESRRG protein binds to NCOA1 protein]affects binding|decreases reaction 11447273
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen inhibits the reaction [PPARGC1A protein binds to ESRRG protein]affects binding|decreases reaction 16889744
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased activity of ESRRG proteindecreases activity 15149736
C016601 4-hydroxytamoxifen bisphenol A inhibits the reaction [4-hydroxytamoxifen binds to and results in decreased activity of ESRRG protein]affects binding|decreases activity|decreases reaction 18197296
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen binds to and results in decreased activity of ESRRG proteinaffects binding|decreases activity 15161930
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen binds to and results in decreased activity of ESRRG proteinaffects binding|decreases activity 16515477
C062262 4-hydroxytoremifene 4-hydroxytoremifene results in decreased activity of ESRRG proteindecreases activity 15149736
C062262 4-hydroxytoremifene 4-hydroxytoremifene binds to and results in decreased activity of ESRRG proteinaffects binding|decreases activity 16515477
D000082 Acetaminophen Acetaminophen affects the expression of ESRRG mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ESRRG proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in increased expression of ESRRG mRNAincreases expression 20458559
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of ESRRG mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ESRRG mRNAdecreases expression 20106945
C004541 biochanin A biochanin A promotes the reaction [ESRRG protein binds to PNRC1 protein]affects binding|increases reaction 14638870
C006780 bisphenol A bisphenol A analog binds to ESRRG proteinaffects binding 18197296
C006780 bisphenol A bisphenol A binds to and results in increased activity of ESRRG proteinaffects binding|increases activity 20427257
C006780 bisphenol A bisphenol A binds to ESRRG proteinaffects binding 19304792
18197296
C006780 bisphenol A bisphenol A inhibits the reaction [4-hydroxytamoxifen binds to and results in decreased activity of ESRRG protein]affects binding|decreases activity|decreases reaction 18197296
D016572 Cyclosporine Cyclosporine results in decreased expression of ESRRG mRNAdecreases expression 20106945
C004742 daidzein daidzein promotes the reaction [ESRRG protein binds to PNRC1 protein]affects binding|increases reaction 14638870
D016047 Zalcitabine [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ESRRG mRNAaffects cotreatment|decreases expression 18606552
D004041 Dietary Fats Dietary Fats results in increased expression of ESRRG mRNAincreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol binds to and affects the activity of ESRRG proteinaffects activity|affects binding 16889744
D004054 Diethylstilbestrol Diethylstilbestrol binds to and results in decreased activity of ESRRG proteinaffects binding|decreases activity 11559547
14751226
D004054 Diethylstilbestrol Diethylstilbestrol binds to and results in increased activity of ESRRG proteinaffects binding|increases activity 12579585
D004054 Diethylstilbestrol Diethylstilbestrol binds to ESRRG proteinaffects binding 11447273
17049190
D004054 Diethylstilbestrol Diethylstilbestrol inhibits the reaction [ESRRG protein results in increased expression of TFF1 mRNA]decreases reaction|increases expression 11559547
D004054 Diethylstilbestrol Diethylstilbestrol binds to and results in decreased activity of ESRRG proteinaffects binding|decreases activity 15161930
D004054 Diethylstilbestrol Diethylstilbestrol binds to and results in increased activity of ESRRG proteinaffects binding|increases activity 12579585
D004054 Diethylstilbestrol Diethylstilbestrol binds to and results in decreased activity of ESRRG proteinaffects binding|decreases activity 16515477
D019833 Genistein Genistein promotes the reaction [ESRRG protein binds to PNRC1 protein]affects binding|increases reaction 14638870
C514793 gp120 protein, Human immunodeficiency virus 1 [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ESRRG mRNAaffects cotreatment|decreases expression 18606552
C501618 N'-((1E)-(4-(diethylamino)phenyl)methylene)-4-hydroxybenzohydrazide N'-((1E)-(4-(diethylamino)phenyl)methylene)-4-hydroxybenzohydrazide binds to and results in increased activity of ESRRG proteinaffects binding|increases activity 15713377
C041786 palm oil palm oil results in increased expression of ESRRG mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ESRRG mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of ESRRG mRNAincreases expression 18301758
D013629 Tamoxifen Tamoxifen binds to and affects the activity of ESRRG proteinaffects activity|affects binding 16889744
D013629 Tamoxifen Tamoxifen binds to ESRRG proteinaffects binding 11447273
D013629 Tamoxifen Tamoxifen inhibits the reaction [PPARGC1A protein binds to ESRRG protein]affects binding|decreases reaction 16889744
C004648 testosterone enanthate testosterone enanthate affects the expression of ESRRG mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of ESRRG mRNAaffects binding|increases expression 16214954
C012589 trichostatin A trichostatin A results in increased activity of ESRRG proteinincreases activity 11705994
C025643 vinclozolin vinclozolin affects the expression of ESRRG mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6611752688 15322242 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 2.9418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 9.8411798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.8420127859 20464547
MESH:D000230 Adenocarcinoma daidzein 9.8411473722
MESH:D000230 Adenocarcinoma Genistein 9.8411473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.546695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2616835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3015469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4919015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8819183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.7015238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.2816206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.2819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.2812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001862 Bone Resorption bisphenol A 3.6911985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6520146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 3.6517123778
MESH:D001943 Breast Neoplasms Dietary Fats 3.6520435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.6515324884 17129689
MESH:D001943 Breast Neoplasms Genistein 3.6517200150 16873071 16541309
MESH:D001943 Breast Neoplasms Tamoxifen 3.6518425577 19189210 20859285 19142967 17242785 19221464 19066611 16202921 21138602 18815881 19288272 15668708 16873071 18351453 20065188 19011961 19289846 17049068 21152245 17440819 17261762 19115204 19200415 17893378 20005174 20544844 18821012 19189212 18997820 19487384 18984771 19155303 19410462 18629630 16818667 15565566 20390343 19084267 19103187 18855134 19059307 20135344 11161223 19244106 16273361
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6520435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1511589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.983084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 10.9812907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 10.9816217749 11135700 14691202 15073043 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 10.9816924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Genistein 10.9816924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.9816924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.8017123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6819014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9512490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0020419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2618670907 16120746 18850075
MESH:D009202 Cardiomyopathies Zalcitabine 4.5910591146
MESH:D002318 Cardiovascular Diseases daidzein 7.3616332659
MESH:D002318 Cardiovascular Diseases Genistein 7.3616332659
MESH:D002386 Cataract Acetaminophen 2.4710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.4012371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0016835633
MESH:D002779 Cholestasis Cyclosporine 7.2919486331
MESH:D002779 Cholestasis pirinixic acid 7.2919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0316354765 8697196 12621046 15340226 15668235
MESH:D003110 Colonic Neoplasms Genistein 2.2617182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9017141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4115322242 10048152 20055451
MESH:D003456 Cryptorchidism Diethylstilbestrol 10.7612952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 10.7614966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9215213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 6.9916647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.9916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.9917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.3219279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.3712153990 16177239 19420014 18713872 12540782 19739265 14550746 10915739 15619225 16227642 10774834 15968718 10663392 16781746 12392966 18071297 11529661 16109766 2444490 11739529 19164858 19085960 12594235 11834606 12958197 19416960 16485898 14986274 16393943 12705907 11421492 14725611 19923254 11287661 17522070 11743745 19370779 11461765 17562736 16081117 17906064
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.3720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0811462148
MESH:D004362 Drug Toxicity Zalcitabine 8.087515130
MESH:D050171 Dyslipidemias Dietary Fats 3.3218367378
MESH:D004487 Edema pirinixic acid 5.9712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.9711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7116714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.3619031437
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 5.4519294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.2516402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.2516402032
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 22.0719148513
MESH:D016889 Endometrial Neoplasms daidzein 22.0711473722
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 22.0716804899 15700306
MESH:D016889 Endometrial Neoplasms Genistein 22.0711473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 22.0716202921 17893378 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.869294722 10568697
MESH:D007172 Erectile Dysfunction daidzein 4.8314972507
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.2712903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005234 Fatty Liver arsenic trioxide 28.4715073043
MESH:D005234 Fatty Liver Cyclosporine 28.4719224547
MESH:D005234 Fatty Liver Dietary Fats 28.4717967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver pirinixic acid 28.4719236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 28.4719224547 14986274
MESH:D005234 Fatty Liver Zalcitabine 28.4718299183
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.8316513791 16002989 16534752 15751030 16611131
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.8316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005355 Fibrosis Cyclosporine 13.6212639820 12168785
MESH:D005355 Fibrosis Dietary Fats 13.6218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.6220067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0816904648
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7416973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1116417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D005909 Glioblastoma biochanin A 11.4816598420
MESH:D005909 Glioblastoma Genistein 11.4816598420
MESH:D005909 Glioblastoma trichostatin A 11.4818801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006529 Hepatomegaly pirinixic acid 7.6316221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.6315340226 16120746 12621046
MESH:D015658 HIV Infections Zalcitabine 4.2417457083
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.5517440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8515340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5516870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4221332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4421332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2512960047 14722030
MESH:D006973 Hypertension Cyclosporine 8.2610903974
MESH:D006973 Hypertension daidzein 8.2617169123
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.2618670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 4.3916002989
MESH:D007246 Infertility Diethylstilbestrol 4.1715036965
MESH:D007248 Infertility, Male vinclozolin 2.9216467254
MESH:D007249 Inflammation Dietary Fats 7.7020412841
MESH:D007249 Inflammation Tamoxifen 7.7019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.7012200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 11.6216393666
MESH:D007333 Insulin Resistance Dietary Fats 11.6211836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 11.6216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D007674 Kidney Diseases Acetaminophen 5.4312587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.438314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 11.5412371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.5415003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Tamoxifen 11.5418625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8717184923
MESH:D007938 Leukemia arsenic trioxide 6.1215070760
MESH:D007938 Leukemia Genistein 6.1218980019 17468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.5919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0617050201 20471514 19850784 16968895 16467208
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.0618206229
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0911468182 16823087 15336539 19642359 17217047 17649720 17107899 17712046 16112521 19075265 12018890 9834237 17869043 19035177 19225113 12712474 16966277 15213294 12679006 16891316 15748426 16331271 11161223 16330433 15622746
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1716882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5416417039
MESH:D008064 Lipidoses Tamoxifen 3.0217567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.7718296743
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.7417823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.7418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7412878042
MESH:D008107 Liver Diseases Acetaminophen 1.5916611625 12587719 12969438 11587558 19460945 19784758 19014921 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0716871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.7915890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms arsenic trioxide 20.7914682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.7920195826 21137059
MESH:D008113 Liver Neoplasms Diethylstilbestrol 20.7915890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 20.7915890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 20.7916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.7916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.148603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.1420377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.1412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2115213294
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.8417365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.3214755239
MESH:D008175 Lung Neoplasms arsenic trioxide 6.3219825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.3217053015 18816296 18520028 20464547 20869020 6695378 20064080 20135361 18569708
MESH:D008175 Lung Neoplasms Tamoxifen 6.3218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.3211884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9615166399
MESH:D008223 Lymphoma Diethylstilbestrol 7.7315700306
MESH:D008223 Lymphoma Zalcitabine 7.738764131 17941976 11980663 9488045 9205081 8840982 18798262
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3216002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5719428831
MESH:D008325 Mammary Neoplasms, Experimental Genistein 5.7112929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.7111731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.3519453300
MESH:D008545 Melanoma Tamoxifen 3.4819393235 12393984
MESH:D008545 Melanoma trichostatin A 3.4816505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1118303189 16966607 16166281
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0416381670
MESH:D009101 Multiple Myeloma arsenic trioxide 7.1215949261 14977855 19417148 11468182 19549372
MESH:D009101 Multiple Myeloma trichostatin A 7.1218172295
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0316105982 16882451
MESH:D009203 Myocardial Infarction Genistein 5.4117141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.4119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.9117141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9116411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7816624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.6911141357
MESH:D009369 Neoplasms Diethylstilbestrol 7.6915313581
MESH:D009369 Neoplasms pirinixic acid 7.6917405874
MESH:D009374 Neoplasms, Experimental Zalcitabine 4.919205081 9488045 8764131
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119196722 19189210 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1219348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 21.9516427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 21.9511399458
MESH:D009421 Nervous System Malformations Genistein 21.9516427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.9514600291
MESH:D009437 Neuralgia Zalcitabine 6.1217292584
MESH:D009436 Neural Tube Defects arsenic trioxide 2.9910525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7218514411
MESH:D009765 Obesity Dietary Fats 4.2719632207 17217161 20518802 21332399 18457598 20132043 18674790 11836018 16723640
MESH:D009765 Obesity pirinixic acid 4.2720558911
MESH:D010024 Osteoporosis Genistein 3.1419401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9116169203
MESH:D010049 Ovarian Diseases bisphenol A 4.8011985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.6812452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Genistein 7.6819005980
MESH:D010051 Ovarian Neoplasms trichostatin A 7.6819331143
MESH:D010146 Pain Acetaminophen 2.2416870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.3615580305
MESH:D010190 Pancreatic Neoplasms trichostatin A 5.3619294695
MESH:D010235 Paraganglioma arsenic trioxide 3.9819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010523 Peripheral Nervous System Diseases gp120 protein, Human immunodeficiency virus 1 10.3218606552
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 10.3218606552
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9814722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4815687265 16977796
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.7010923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0612371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 21.6710548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 21.6717184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 21.6711222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 21.6718042343 18220299 19015723
MESH:D055728 Primary Myelofibrosis trichostatin A 5.0617616702
MESH:D011469 Prostatic Diseases vinclozolin 4.7418220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.0320887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.4219131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4217292933
MESH:D011471 Prostatic Neoplasms biochanin A 2.4212111696
MESH:D011471 Prostatic Neoplasms bisphenol A 2.4216740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.4217136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Genistein 2.4215256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4215067354
MESH:D011471 Prostatic Neoplasms trichostatin A 2.4219789329 18798265
MESH:D011472 Prostatitis vinclozolin 4.7418629315
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011629 Puberty, Precocious bisphenol A 4.5910548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9615814490 17365031 17975199 17322281
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7816646077
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.1810029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1816192470
MESH:D013088 Spermatocele Diethylstilbestrol 11.2016709447 16002989
MESH:D013088 Spermatocele Tamoxifen 11.2016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8519457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.3217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3220155912 2093021
MESH:D019966 Substance-Related Disorders bisphenol A 3.7916045194 16684133
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 2.9419014326
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7715213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.3212973940 11780464 12845720 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.3217053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.3216712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.328653321 16712894 17572228
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.8716175088
MESH:D014591 Uterine Diseases bisphenol A 13.1714652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 13.1714652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.8915809267 16690809
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2516513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D015430 Weight Gain Dietary Fats 3.5816723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
Pathway ID Pathway Name
REACT:71 Gene Expression
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27891
    • No data
    Releated disease ID Related disease Name
    PA446714Neoplasm, Residual
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA449594fenofibrate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00197 inverse agonist Troglitazone Antineoplastic Agents;Hypoglycemic Agents;Vasodilator Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents
    DB00255 agonist Diethylstilbestrol Antineoplastic Agents, Hormonal;Carcinogens;Estrogens, Non-Steroidal
    DB02659 - Cholic Acid
    DB06884 - 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
    DB06902 - 4-(1-methyl-1-phenylethyl)phenol
    DB06973 - 4,4'-PROPANE-2,2-DIYLDIPHENOL
    DB07485 - 4,4'-cyclohexane-1,1-diyldiphenol
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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