AutismKB 2.0

Annotation Detail for ETFB


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ETFB ( MADD )
Gene Full Name: electron-transfer-flavoprotein, beta polypeptide
Band: 19q13.41
Quick LinksEntrez ID:2109; OMIM: 130410; Uniprot ID:ETFB_HUMAN; ENSEMBL ID: ENSG00000105379; HGNC ID: 3482
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncou
No data
No data
Pathway IDPathway Name
500282Respiratory electron transport
Related Diseases/Disorders Top
Desease IDDesease Name
H00178Glutaric acidemia
Inherited disorders of amino acid metabolism
Genetic disorders
No data
No data
No data
Desease Name
Glutaricaciduria, type IIB
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C065250 4-hydroxy-equilenin 4-hydroxy-equilenin results in decreased expression of ETFB mRNAdecreases expression 15135645
D000082 Acetaminophen Acetaminophen affects the expression of ETFB mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ETFB proteinaffects expression 20106945
D000638 Amiodarone Amiodarone affects the expression of ETFB mRNAaffects expression 19483382
D001553 Benzbromarone Benzbromarone affects the expression of ETFB mRNAaffects expression 19483382
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ETFB mRNAincreases expression 19150397
C006780 bisphenol A bisphenol A results in decreased expression of ETFB mRNAdecreases expression 15223131
C006780 bisphenol A ESR1 protein affects the reaction [bisphenol A results in decreased expression of ETFB mRNA]affects reaction|decreases expression 15223131
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ETFB mRNAdecreases expression 15336504
D002994 Clofibrate Clofibrate affects the expression of ETFB mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in decreased expression of ETFB mRNAdecreases expression 20106945
D004317 Doxorubicin ETFB protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004958 Estradiol ESR1 protein affects the reaction [Estradiol results in decreased expression of ETFB mRNA]affects reaction|decreases expression 15223131
D004958 Estradiol Estradiol results in decreased expression of ETFB mRNAdecreases expression 15223131
D005001 Ethionine Ethionine affects the expression of ETFB mRNAaffects expression 19483382
D005472 Fluorouracil ETFB protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
D008628 Mercury Mercury results in increased expression of ETFB mRNAincreases expression 16823088
D009853 Omeprazole Omeprazole affects the expression of ETFB mRNAaffects expression 19483382
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ETFB mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of ETFB mRNAincreases expression 17426115
18301758
C006253 pirinixic acid pirinixic acid affects the expression of ETFB mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of ETFB mRNAaffects expression 19483382
D018038 Sodium Selenite Sodium Selenite results in increased expression of ETFB mRNAincreases expression 18175754
C025462 sulindac sulfide sulindac sulfide results in decreased expression of ETFB mRNAdecreases expression 16184548
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ETFB mRNAincreases expression 20106945
11489354
D013853 Thioacetamide Thioacetamide affects the expression of ETFB mRNAaffects expression 19483382
D014747 Vinblastine ETFB protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7015322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000230 Adenocarcinoma Doxorubicin 6.9417418594
MESH:D000230 Adenocarcinoma Estradiol 6.9411473722
MESH:D000230 Adenocarcinoma Fluorouracil 6.9417638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3916835633
MESH:D000419 Albuminuria Doxorubicin 4.4021441931
MESH:D000544 Alzheimer Disease sulindac sulfide 3.0618759972
MESH:D000740 Anemia Fluorouracil 8.2415504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.2411748828
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6720041841 18057881 18218290
MESH:D001281 Atrial Fibrillation Amiodarone 3.7919698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Mercury 2.1417497416
MESH:D001327 Autoimmune Diseases Mercury 4.7216634805
MESH:D001778 Blood Coagulation Disorders Amiodarone 55.7019483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 55.7019483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 55.7019483382
MESH:D001778 Blood Coagulation Disorders Ethionine 55.7019483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 55.7019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 55.7019483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 55.7019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 55.7012125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 55.7019483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5514601052
MESH:D001862 Bone Resorption bisphenol A 3.7211985600
MESH:D001932 Brain Neoplasms Doxorubicin 3.6817150277
MESH:D001943 Breast Neoplasms bisphenol A 2.2917123778
MESH:D001943 Breast Neoplasms Doxorubicin 2.2916595493 15136595 15668708 16096432 16115903 15939500 16826403 19526202 15634643 15567936 16935488 16264153 18628466 16322301 17983394 17426702 15993339 18695136 18234424 11325840 15692762 18382427 15994142 17369602
MESH:D001943 Breast Neoplasms Estradiol 2.2912948864 17289903 18497071 19861407 17018787 16675129 17261762 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 2.2919217205 18608205 16595493 16110121 15136595 16557594 18357371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D002276 Carcinoid Tumor Doxorubicin 11.8516051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.8516051944
MESH:D002277 Carcinoma Fluorouracil 7.7817121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.7816835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.723084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.7221507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 13.721701930
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 13.7218059187 16234567 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.7216924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.7218930000 17045692 16799960 16332177 17971768 17088986
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 13.7217997003
MESH:D002278 Carcinoma in Situ bisphenol A 4.8417123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.4012391285
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.5316201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.5318695887
MESH:D002292 Carcinoma, Renal Cell Vinblastine 10.531485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.716189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7116757204 16280240 17066447 18986760
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.4317007740 15505089 16278810 17329180 16952015 16651473 17382496 16269455 17974986 16731534 16612575 16364871 15792986 17131338 16242529 17928571 17924179 16109756 16455267 15476868 15811867 17351982 17519947 18627295 17308081
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 9.3515710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 9.3516243910 17334414
MESH:D002311 Cardiomyopathy, Dilated Mercury 9.3510334427
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.9318974383
MESH:D002386 Cataract Acetaminophen 2.4910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.1820889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 15.181399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.1812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.1818566989
MESH:D002637 Chest Pain Omeprazole 4.9615447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.1216835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.1218291259
MESH:D002779 Cholestasis Cyclosporine 7.3919486331
MESH:D002779 Cholestasis pirinixic acid 7.3919176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6015894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0416354765 8697196 15668235 15340226 12621046
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2116510598 16340194 17287894 17169374 17018589 18772588 17725105 15001691 17016597 17172411
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.5218802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.5216282729 16391804 18802399 18949393 17454858 17255274 17695437 16524972 15148649 18288408 17401013 20501625 18509181 14970324 16303861 17094418 18383874 18448328 16331619 15289873 17594712 17016601
MESH:D015179 Colorectal Neoplasms Vinblastine 3.5218802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D007644 Darier Disease Fluorouracil 4.6416733453
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.6516823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6516285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6317107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2819279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.6818713872 11421492 12392966 10663392 19923254 11834606 12153990 14725611 2444490 17522070 14550746 19416960 12540782 16109766 10774834 11529661 15619225 17906064 19420014 16227642 11743745 11461765 11739529 10915739 19085960 16081117 16393943 16781746 12594235 19739265 19164858 12958197 15968718 14986274 16177239 18071297 19370779 12705907 17562736 11287661 16485898
MESH:D056486 Drug-Induced Liver Injury Amiodarone 14.6818218290 15265979
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 14.6817416283
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 14.6815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.6820420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 14.6812963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Doxorubicin 7.7418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.7411462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.1815991576 16613094 21218061 17151854
MESH:D050171 Dyslipidemias Clofibrate 3.9616707586
MESH:D004487 Edema pirinixic acid 6.0812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7516714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.2117359293
MESH:D016889 Endometrial Neoplasms Estradiol 7.2119148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.899294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0118037988
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3820426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.3817638652 16337965 16481741 15173087 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005218 Fat Necrosis Thioacetamide 5.5716456712
MESH:D005234 Fatty Liver Amiodarone 17.6614986274
MESH:D005234 Fatty Liver Clofibrate 17.6619224547
MESH:D005234 Fatty Liver Cyclosporine 17.6619224547
MESH:D005234 Fatty Liver pirinixic acid 17.6620131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4419069698
MESH:D005355 Fibrosis Cyclosporine 7.9812639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.9820067830
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D005909 Glioblastoma Doxorubicin 3.2517150277
MESH:D005910 Glioma Fluorouracil 2.8116145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.5815692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.5815162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2511294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.3818674790 17875725 16707910 16244372 16144979 16495754 16244371 18006777 12587719 16879835 16330681 14766674 17888722
MESH:D006333 Heart Failure Doxorubicin 6.7417481944
MESH:D006333 Heart Failure pirinixic acid 6.7420558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7615692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.4318665440 17276928 15929193
MESH:D006505 Hepatitis Thioacetamide 4.0716456712
MESH:D006529 Hepatomegaly Amiodarone 13.5415265979
MESH:D006529 Hepatomegaly pirinixic acid 13.5418467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.5415340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D006689 Hodgkin Disease Doxorubicin 7.3717606976 18501091 15147373
MESH:D006689 Hodgkin Disease Vinblastine 7.3718501091 18180244
MESH:D019584 Hot Flashes Estradiol 3.6017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.898697196 15340226 16959395 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5816870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.739751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006973 Hypertension Cyclosporine 4.7510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7518670907 18850075
MESH:D007037 Hypothyroidism Amiodarone 11.1118020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 11.1118031379 8137927
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.7812200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 16.8416393666
MESH:D007333 Insulin Resistance Estradiol 16.8416393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 16.8416306350
MESH:D007333 Insulin Resistance Sodium Selenite 16.8414714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Acetaminophen 18.1412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 18.148314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 18.1415369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 18.1415618244
MESH:D007674 Kidney Diseases Mercury 18.1417934191
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0116707910
MESH:D007680 Kidney Neoplasms Cyclosporine 11.6912371664
MESH:D007680 Kidney Neoplasms Estradiol 11.6915610895
MESH:D007680 Kidney Neoplasms Fluorouracil 11.6916985049
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.9719248655
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0116085563
MESH:D008064 Lipidoses Amiodarone 3.4017567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.5316439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5312878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 6.5318416461 15158331 17629604 16126171 11481614 16248980 15288473 15078482 15095483 18458672 15075984 15288472 16098781 11682029 18032466 18295389 15474484 18031379 15316131 17355460 12531686 15716488 15334695 18380797 11172339 16343077 12557150 18263696 18606216 18615449 18395095 17292413 16511523 16489207 14739098 12679928 15362042 12175628 10677585 17127702 12891558 17050028 16097051 12085344 15465738
MESH:D008107 Liver Diseases Acetaminophen 4.0016610002 19784758 12587719 19460945 11587558 12969438 16611625 19014921
MESH:D008107 Liver Diseases Thioacetamide 4.0015158337 18374380 16337175
MESH:D017114 Liver Failure, Acute Acetaminophen 9.1917185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 9.1917276928 15313186 15633222 12479984
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.219163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Fluorouracil 10.2116603448 15113037 18383874 17045692
MESH:D008113 Liver Neoplasms pirinixic acid 10.2120007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.2116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.328603461
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.3217085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.3212151625
MESH:D008133 Long QT Syndrome Amiodarone 3.4617391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.2712587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.3318516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.7214755239
MESH:D008175 Lung Neoplasms Doxorubicin 4.7217418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 4.7215246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7219555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6415086387
MESH:D008223 Lymphoma Doxorubicin 3.3516098063
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9214737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6717654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4215621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 5.8015458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.8011807958 11408345 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.3319453300
MESH:D008545 Melanoma Doxorubicin 3.7016827129
MESH:D008545 Melanoma Vinblastine 3.7016809738 18332650 17761969 18176117 15577323 12374674 16432458 15577320 18505091 16248763
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008654 Mesothelioma Doxorubicin 3.0017638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3615792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.5116757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.6417415656
OMIM:231680 MULTIPLE ACYL-CoA DEHYDROGENASE DEFICIENCY marker/mechanism
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009181 Mycoses Amiodarone 4.7517974566 12754197
MESH:D009203 Myocardial Infarction Doxorubicin 5.5019429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 5.5019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.8616411023
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.8918259882
MESH:D009369 Neoplasms Fluorouracil 4.7416928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 4.7417405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5817289903
MESH:D009401 Nephrosis Doxorubicin 4.6216899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.8718481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.8716889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 15.5011399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 15.5016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.5014600291
MESH:D009447 Neuroblastoma Doxorubicin 3.1915555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7518514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3416436463
MESH:D009503 Neutropenia Vinblastine 4.4317378895
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.799802331
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D012516 Osteosarcoma Doxorubicin 3.9915930896
MESH:D010049 Ovarian Diseases bisphenol A 4.8411985600
MESH:D010051 Ovarian Neoplasms Estradiol 2.1719401270
MESH:D010146 Pain Acetaminophen 2.2716870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.6119003803 16929163 15113037 16500647
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0117983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0117638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0912371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.0010548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0011896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.0920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.0920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8816740699
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8815749863 15897917 16868541 18437689 16729912 16888761
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8818626508 19082440
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.8818760546
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011629 Puberty, Precocious bisphenol A 4.6310548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8012490602 11597910 12832656
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8816160472 15538739 18286688 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 4.0717922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012509 Sarcoma Doxorubicin 3.8618313854 16767912 17710206 15625365 15675481 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.0916326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6417846226
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.9318724381
MESH:D012878 Skin Neoplasms Doxorubicin 9.0615692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.068532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.0616192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4215625365 17203757 16767912
MESH:D013272 Stomach Diseases Omeprazole 4.4618545984
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0016424979 17498489 18396642 18567086 17522103 19015929 19084572 16951190 15786421 17172411
MESH:D013276 Stomach Ulcer Amiodarone 7.1218087811
MESH:D013276 Stomach Ulcer Omeprazole 7.1216755016 18237397 10750652 15991576 17977527 11906479
MESH:D019966 Substance-Related Disorders bisphenol A 3.8316684133 16045194
MESH:D013610 Tachycardia Amiodarone 4.1411238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0419225199
MESH:D013959 Thyroid Diseases Amiodarone 11.5519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.5512697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.1717909728 16010429
MESH:D013964 Thyroid Neoplasms Propylthiouracil 7.1715710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.7118020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.5319048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8516280240
MESH:D016171 Torsades de Pointes Amiodarone 4.0411989578 17467628
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.7117653716
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.7416803524
MESH:D014591 Uterine Diseases bisphenol A 4.8614652134
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.5118645019
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D014625 Vaginal Neoplasms Vinblastine 4.8915577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0717678736 16364871 17334414 17638931
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
Pathway ID Pathway Name
REACT:6305 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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