AutismKB 2.0

Annotation Detail for ALAS1


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Basic Information Top
Gene Symbol:ALAS1 ( ALAS,ALAS3,ALASH,MIG4 )
Gene Full Name: aminolevulinate, delta-, synthase 1
Band: 3p21.2
Quick LinksEntrez ID:211; OMIM: 125290; Uniprot ID:HEM1_HUMAN; ENSEMBL ID: ENSG00000023330; HGNC ID: 396
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5920heme biosynthesis II
PWY-5189tetrapyrrole biosynthesis II
Pathway IDPathway Name
hsa00860Porphyrin and chlorophyll metabolism
hsa01100Metabolic pathways
hsa00260Glycine, serine and threonine metabolism
Pathway IDPathway Name
Metabolism of porphyrins
Pathway IDPathway Name
200073FOXA2 and FOXA3 transcription factor networks
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1867Liver failure
1934Cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009947 1,2,4-trichlorobenzene 1,2,4-trichlorobenzene results in increased activity of ALAS1 proteinincreases activity 6636202
C009947 1,2,4-trichlorobenzene 1,2,4-trichlorobenzene results in increased activity of ALAS1 proteinincreases activity 6895089
11996131
C009947 1,2,4-trichlorobenzene Buthionine Sulfoximine inhibits the reaction [1,2,4-trichlorobenzene results in increased activity of ALAS1 protein]decreases reaction|increases activity 11996131
C083522 2,3,5-trichlorophenyl methyl sulfone 2,3,5-trichlorophenyl methyl sulfone results in increased activity of ALAS1 proteinincreases activity 11996131
C014024 2,4,5,2',4',5'-hexachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of ALAS1 mRNAaffects cotreatment|decreases expression 16984957
C023035 3,4,5,3',4'-pentachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of ALAS1 mRNAaffects cotreatment|decreases expression 16984957
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ALAS1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ALAS1 mRNAaffects expression 15606129
17562736
D000082 Acetaminophen Acetaminophen affects the expression of ALAS1 mRNAaffects expression 17366322
D024502 alpha-Tocopherol alpha-Tocopherol inhibits the reaction [Paraquat results in increased activity of ALAS1 protein]decreases reaction|increases activity 12180188
D000638 Amiodarone Amiodarone results in increased expression of ALAS1 mRNAincreases expression 19774075
C006632 arsenic trioxide arsenic trioxide results in increased expression of ALAS1 mRNAincreases expression 15725085
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ALAS1 mRNAincreases expression 20106945
C006780 bisphenol A bisphenol A results in increased expression of ALAS1 mRNAincreases expression 17010207
D019328 Buthionine Sulfoximine Buthionine Sulfoximine inhibits the reaction [1,2,4-trichlorobenzene results in increased activity of ALAS1 protein]decreases reaction|increases activity 11996131
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ALAS1 mRNAaffects expression 16239168
D002706 Chlordan Chlordan results in increased activity of ALAS1 proteinincreases activity 7157408
C031294 chlorobenzene chlorobenzene results in increased activity of ALAS1 proteinincreases activity 6895089
D003474 Curcumin Curcumin results in increased expression of ALAS1 mRNAincreases expression 18299980
D003513 Cycloheximide Cycloheximide inhibits the reaction [Heptachlor results in increased activity of ALAS1 protein]decreases reaction|increases activity 9879810
D003513 Cycloheximide Cycloheximide inhibits the reaction [Lindane results in increased activity of ALAS1 protein]decreases reaction|increases activity 9879810
D003609 Dactinomycin Dactinomycin inhibits the reaction [Heptachlor results in increased activity of ALAS1 protein]decreases reaction|increases activity 9879810
D004958 Estradiol Estradiol results in increased expression of ALAS1 mRNAincreases expression 20106945
D004958 Estradiol Estradiol affects the expression of ALAS1 mRNAaffects expression 15598610
D004958 Estradiol Estradiol results in increased expression of ALAS1 mRNAincreases expression 16684588
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of ALAS1 mRNAaffects cotreatment|increases expression 17347304
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ALAS1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ALAS1 mRNAdecreases expression 15901920
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of ALAS1 mRNAaffects cotreatment|increases expression 17347304
D005419 Flavonoids Flavonoids results in decreased expression of ALAS1 mRNAdecreases expression 18035473
C088563 fomesafen fomesafen results in increased expression of ALAS1 mRNAincreases expression 12758057
D019833 Genistein Genistein results in increased expression of ALAS1 mRNAincreases expression 17010207
D006427 Hemin Hemin inhibits the reaction [Heptachlor results in increased activity of ALAS1 protein]decreases reaction|increases activity 9879810
D006427 Hemin Hemin inhibits the reaction [Lindane results in increased activity of ALAS1 protein]decreases reaction|increases activity 9879810
D006533 Heptachlor Cycloheximide inhibits the reaction [Heptachlor results in increased activity of ALAS1 protein]decreases reaction|increases activity 9879810
D006533 Heptachlor Dactinomycin inhibits the reaction [Heptachlor results in increased activity of ALAS1 protein]decreases reaction|increases activity 9879810
D006533 Heptachlor Hemin inhibits the reaction [Heptachlor results in increased activity of ALAS1 protein]decreases reaction|increases activity 9879810
D006533 Heptachlor Heptachlor results in increased activity of ALAS1 proteinincreases activity 9879810
D001556 Lindane Cycloheximide inhibits the reaction [Lindane results in increased activity of ALAS1 protein]decreases reaction|increases activity 9879810
D001556 Lindane Hemin inhibits the reaction [Lindane results in increased activity of ALAS1 protein]decreases reaction|increases activity 9879810
D001556 Lindane Lindane results in increased activity of ALAS1 proteinincreases activity 9879810
D008294 Malathion Malathion results in increased activity of ALAS1 proteinincreases activity 7157408
D020366 Methylmethacrylate Methylmethacrylate results in increased expression of ALAS1 mRNAincreases expression 16916219
C025256 nonylphenol nonylphenol results in increased expression of ALAS1 mRNAincreases expression 17010207
D010269 Paraquat alpha-Tocopherol inhibits the reaction [Paraquat results in increased activity of ALAS1 protein]decreases reaction|increases activity 12180188
D010269 Paraquat Paraquat results in increased activity of ALAS1 proteinincreases activity 12180188
D010634 Phenobarbital Phenobarbital results in increased expression of ALAS1 mRNAincreases expression 15629111
D010634 Phenobarbital Phenobarbital results in decreased expression of ALAS1 mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of ALAS1 mRNAincreases expression 19270015
D010795 Phthalic Acids Phthalic Acids results in decreased expression of ALAS1 mRNAdecreases expression 15728792
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ALAS1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid affects the expression of ALAS1 mRNAaffects expression 18445702
C023666 pyridine pyridine results in increased activity of ALAS1 proteinincreases activity 10413312
D012643 Selenium Selenium results in increased expression of ALAS1 mRNAincreases expression 19244175
C009250 sevoflurane sevoflurane affects the expression of ALAS1 mRNAaffects expression 15967596
C009277 sodium arsenate sodium arsenate results in increased expression of ALAS1 mRNAincreases expression 16882884
C075117 squalestatin 1 squalestatin 1 results in increased expression of ALAS1 mRNAincreases expression 15629111
D013311 Streptozocin Streptozocin results in decreased expression of ALAS1 mRNAdecreases expression 16684804
D013311 Streptozocin vanadyl sulfate inhibits the reaction [Streptozocin results in decreased expression of ALAS1 mRNA]decreases expression|decreases reaction 16684804
C446685 systhane systhane results in increased expression of ALAS1 mRNAincreases expression 19409404
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ALAS1 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ALAS1 mRNAincreases expression 18163543
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ALAS1 mRNAdecreases expression 18657588
16466705
16054898
D014212 Tretinoin Tretinoin results in increased expression of ALAS1 mRNAincreases expression 16140955
17218384
C032910 triadimefon triadimefon results in increased expression of ALAS1 mRNAincreases expression 19409404
C034028 vanadyl sulfate vanadyl sulfate inhibits the reaction [Streptozocin results in decreased expression of ALAS1 mRNA]decreases expression|decreases reaction 16684804
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 11.4518926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.456195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.4515322242 11752688 14514962
MESH:D000138 Acidosis Ethanol 4.0111192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4517505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.6718653653
MESH:D000230 Adenocarcinoma arsenic trioxide 11.9411798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 11.9420127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 11.9411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 11.9414692618
MESH:D000230 Adenocarcinoma Genistein 11.9411473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 5.613712494
MESH:D000236 Adenoma Benzo(a)pyrene 5.616695378
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 20.9316628245
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.9317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.9316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.9316835633
MESH:D000382 Agricultural Workers' Diseases Heptachlor 16.5912661182
MESH:D000382 Agricultural Workers' Diseases Lindane 16.5912661182
MESH:D000382 Agricultural Workers' Diseases Malathion 16.5911874814 17119214
MESH:D000382 Agricultural Workers' Diseases Paraquat 16.5911874814
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.8215451040 15451039
MESH:D019973 Alcohol-Related Disorders Curcumin 4.5817887948
MESH:D000505 Alopecia Tretinoin 3.2315955085
MESH:D000544 Alzheimer Disease Curcumin 2.5015590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5311748828
MESH:D000799 Angioedema Acetaminophen 3.3510982225
MESH:D000853 Anophthalmos Ethanol 4.3415513904
MESH:D001008 Anxiety Disorders Ethanol 3.6211141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6019183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.3818218290 18057881 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.1615885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.1616412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.2716807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.2716292516
MESH:D001249 Asthma Tretinoin 2.1816456186
MESH:D050197 Atherosclerosis Curcumin 3.0218704882
MESH:D001281 Atrial Fibrillation Amiodarone 3.5419698954 18651412
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.0320106747
MESH:D001321 Autistic Disorder Acetaminophen 1.4818445737
MESH:D001327 Autoimmune Diseases Curcumin 4.0219761891
MESH:D001471 Barrett Esophagus Tretinoin 3.9416935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.5211289319 1440618
MESH:D001778 Blood Coagulation Disorders Amiodarone 24.1919483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 24.1916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 24.1919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 24.1912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 24.1916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4415746008
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 5.0414601052
MESH:D001862 Bone Resorption bisphenol A 3.4311985600
MESH:D002545 Brain Ischemia Curcumin 3.8516770732
MESH:D001932 Brain Neoplasms Curcumin 3.5217596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.3220146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 6.3217123778
MESH:D001943 Breast Neoplasms Curcumin 6.3219250217 18593918 18462866 16243823
MESH:D001943 Breast Neoplasms Estradiol 6.3219861407 12948864 18497071 16675129 17018787 17289903 17261762 14630087
MESH:D001943 Breast Neoplasms Genistein 6.3216873071 17200150 16541309
MESH:D001943 Breast Neoplasms Heptachlor 6.328738476
MESH:D001943 Breast Neoplasms Lindane 6.3214688026
MESH:D001943 Breast Neoplasms Malathion 6.3212762645
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.3220435547
MESH:D001943 Breast Neoplasms Tretinoin 6.3216873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1016813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.8811589617
MESH:D002056 Burns Ethanol 4.1816374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3118705752 15721981 16124888 15700767 3786805 16192424 16011737 16050911 16097048 15673190 10355542 16227642
MESH:D002276 Carcinoid Tumor Streptozocin 5.1016051944
MESH:D002277 Carcinoma Curcumin 7.0018593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.0016835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6616168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 20.777296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 20.773084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 20.7715073043 16217749 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 20.7718788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 20.7716924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 20.7718788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Genistein 20.7716924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 20.7717173139 1701930 20007298 20935162 6705139
MESH:D006528 Carcinoma, Hepatocellular pyridine 20.7710696769
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 20.771917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.5017123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7918414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.3819014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.437296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.6912490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.5920419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 6.5918462866
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.5916096774 16051514
MESH:D006332 Cardiomegaly Ethanol 5.9019332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.9016120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7115710769 19225199
MESH:D002318 Cardiovascular Diseases Genistein 2.9616332659
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.6018974383
MESH:D002386 Cataract Acetaminophen 6.2310977129
MESH:D002386 Cataract Tretinoin 6.2317460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 5.537505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.5318566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.784080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1016129372
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 8.4516628245
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.4516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 11.2619486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 11.2616919318 17110522 16105132 15861022 17681005 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 11.2619176532
MESH:D002822 Choriocarcinoma Tretinoin 4.6616461808
MESH:D002971 Cleft Lip Ethanol 3.3215513904
MESH:D002972 Cleft Palate Ethanol 12.2815513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 12.2815340226 16354765 15668235 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 12.289407595
MESH:D002972 Cleft Palate triadimefon 12.2816781842
MESH:D003092 Colitis Curcumin 13.3018200517 16782535 16804969
MESH:D003092 Colitis Selenium 13.3017936198
MESH:D003092 Colitis Tretinoin 13.3017035595
MESH:D003103 Coloboma Curcumin 4.1118809619
MESH:D003110 Colonic Neoplasms Curcumin 3.5819359593 16340194
MESH:D003110 Colonic Neoplasms Genistein 3.5817182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8520501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6517141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.4218497527
MESH:D023903 Coronary Restenosis arsenic trioxide 3.7212609071
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 10.7117686920
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 10.7110525206
MESH:D019465 Craniofacial Abnormalities Ethanol 10.7119302082 10194807 15451039 11873399 15513904 15451040 11198716
MESH:D019465 Craniofacial Abnormalities sodium arsenate 10.7110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 10.7110048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 10.7110589399 9125849 17551590 9664655 16925845 8800419 14991402 9142499 9211117 9224671
MESH:D019465 Craniofacial Abnormalities triadimefon 10.7116875885 15834900
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.6515213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.3611298694 11906362 8970840 14531868 8156756 2524372 12868966 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.043621924 2952479
MESH:D003920 Diabetes Mellitus Streptozocin 4.3216285004
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 7.7316286809 15298345 19496084 1374869 16684804 12644472 19960420 12093613 17874149 7637645 12446591 8740154 15831366 17442507 18603373 6379147 11260395 19298542 15862027 12083368 19586609 18715473 2177838 11055810
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 7.7316684804
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.4718603373
MESH:D003924 Diabetes Mellitus, Type 2 alpha-Tocopherol 12.1216506275
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 12.1218403477
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 12.1216647724
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 12.1219647726 19586609
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 12.1217107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.2416025228
MESH:D003928 Diabetic Nephropathies Curcumin 12.8218204486
MESH:D003928 Diabetic Nephropathies Estradiol 12.8219279558
MESH:D003928 Diabetic Nephropathies Streptozocin 12.8219682444 19960420
MESH:D003930 Diabetic Retinopathy Streptozocin 4.9617662242
MESH:D056486 Drug-Induced Liver Injury 1,2,4-trichlorobenzene 22.5210092053
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 22.528291058 6482804 9022650 9328219 18289764 18648102 18692083 11289319 6679447 9653073 16192314 1440618 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 22.5216177239 12153990 11287661 19416960 19739265 12540782 16081117 18713872 12705907 11743745 17906064 14550746 16109766 11461765 14986274 16781746 18071297 14725611 10915739 11739529 15968718 12958197 19085960 17522070 19923254 11529661 11421492 19420014 11834606 12392966 19164858 15619225 10663392 2444490 16393943 12594235 10774834 16227642 17562736 16485898 19370779
MESH:D056486 Drug-Induced Liver Injury Amiodarone 22.5218218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 22.523786805 3732212 4309450 10092053 6623471 6884620 19336974 7179309 15998439 21278145 11566570 10915739 15968718 15027814 17522070 16227642 7120509 9327722 2869522 19085960 16177239 7440962
MESH:D056486 Drug-Induced Liver Injury Ethanol 22.5211566570
MESH:D056486 Drug-Induced Liver Injury Selenium 22.5215131321
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 22.5218186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 22.5220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4011462148
MESH:D004381 Duodenal Ulcer Curcumin 3.5917351913
MESH:D004421 Dystonia Phenobarbital 3.551851702
MESH:D004487 Edema pirinixic acid 5.1212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.1211000095 12711302
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 18.2217686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 18.2215322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 18.2218230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.7312538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.1016402032
MESH:D016889 Endometrial Neoplasms Estradiol 10.5619148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 10.5611473722
MESH:D016889 Endometrial Neoplasms Tretinoin 10.5616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.6010568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.633659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.3811558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.6320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.136401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.533659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 9.153581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 9.1512903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.1516530937
MESH:D004938 Esophageal Neoplasms Ethanol 9.1516704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.6111564622
MESH:D005124 Eye Abnormalities Tretinoin 7.619664655 16938888
MESH:D005234 Fatty Liver Amiodarone 35.7014986274
MESH:D005234 Fatty Liver arsenic trioxide 35.7015073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 35.7012631006 15959796 16045604 16239168 12795759 17595544 61145 19224547
MESH:D005234 Fatty Liver Curcumin 35.7019297423
MESH:D005234 Fatty Liver Ethanol 35.7019236843 18620774 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 35.7015345470
MESH:D005234 Fatty Liver Fish Oils 35.7018620774
MESH:D005234 Fatty Liver pirinixic acid 35.7019236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1717920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8116946407 15513904 15451040 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9811858732
MESH:D005317 Fetal Growth Retardation 1,2,4-trichlorobenzene 5.796884296
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.526705139
MESH:D005355 Fibrosis Carbon Tetrachloride 17.2818705752
MESH:D005355 Fibrosis Curcumin 17.2818705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.2820067830
MESH:D005355 Fibrosis Tretinoin 17.2817994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.8016904648
MESH:D005756 Gastritis Acetaminophen 9.4816983495
MESH:D005756 Gastritis Ethanol 9.4815046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.2218462866
MESH:D005909 Glioblastoma Curcumin 10.0517596214
MESH:D005909 Glioblastoma Genistein 10.0516598420
MESH:D005909 Glioblastoma Tretinoin 10.0517312396
MESH:D005911 Gliosis Paraquat 4.6711124998
MESH:D018149 Glucose Intolerance sodium arsenate 4.6319446573
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.597505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1010696789
MESH:D006258 Head and Neck Neoplasms Curcumin 6.7718829502 18462866
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.7716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6616084493
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 13.7720471113 17686920
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 13.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 13.7710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 13.779664655 14991402
MESH:D006331 Heart Diseases Streptozocin 3.9312093613
MESH:D006333 Heart Failure pirinixic acid 5.9120558911
MESH:D006333 Heart Failure Selenium 5.9117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9011000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 7.696705139
MESH:D006505 Hepatitis Carbon Tetrachloride 7.6919900420 19110552
MESH:D006529 Hepatomegaly Amiodarone 27.6215265979
MESH:D006529 Hepatomegaly Phenobarbital 27.6216109766
MESH:D006529 Hepatomegaly pirinixic acid 27.6216221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly systhane 27.6217178688 17178689
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 27.6216120746 15340226 12621046
MESH:D006529 Hepatomegaly triadimefon 27.6217178689 17178688
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.5617701891
MESH:D006558 Herpes Genitalis Estradiol 4.5315709030
MESH:D019584 Hot Flashes Estradiol 3.2617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.558697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 10.8416870215
MESH:D006930 Hyperalgesia Ethanol 10.8418783367
MESH:D006930 Hyperalgesia Tretinoin 10.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0416899240
MESH:D006937 Hypercholesterolemia Amiodarone 7.898137927 9751232
MESH:D006937 Hypercholesterolemia Curcumin 7.8918704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0916778211
MESH:D006943 Hyperglycemia pirinixic acid 2.7620558911
MESH:D006949 Hyperlipidemias Fish Oils 4.3115752949
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.4615034207
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.0111484837
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6115338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3316569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 4.0418020914 17991464
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0112013081
MESH:D007248 Infertility, Male Chlordan 9.559432128
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.5517937319
MESH:D007248 Infertility, Male Paraquat 9.554850670
MESH:D007249 Inflammation Curcumin 6.8117151092 18403477 16956363
MESH:D007249 Inflammation Flavonoids 6.8117296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 6.8112200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0018596194 18200517
MESH:D007251 Influenza, Human Selenium 3.7016624496
MESH:D007333 Insulin Resistance bisphenol A 10.4116393666
MESH:D007333 Insulin Resistance Estradiol 10.4116627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 10.4116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.2917994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.8010783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.528074119 9022650
MESH:D007569 Jaw Abnormalities Ethanol 21.0715513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 21.0716580747
MESH:D007569 Jaw Abnormalities Tretinoin 21.0715992940 17551590
MESH:D007569 Jaw Abnormalities triadimefon 21.0715992940 15834900
MESH:D007674 Kidney Diseases Acetaminophen 8.4712587719 15629191
MESH:D007674 Kidney Diseases Estradiol 8.4715618244
MESH:D007674 Kidney Diseases Streptozocin 8.4712093613
MESH:D007676 Kidney Failure, Chronic Selenium 3.4516518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 10.406582329
MESH:D007680 Kidney Neoplasms Estradiol 10.4015610895
MESH:D007680 Kidney Neoplasms pyridine 10.4010696769
MESH:D007859 Learning Disorders Ethanol 8.4715451040
MESH:D007859 Learning Disorders sevoflurane 8.4719212262
MESH:D007889 Leiomyoma Curcumin 4.1218555241
MESH:D007938 Leukemia arsenic trioxide 12.8315070760
MESH:D007938 Leukemia Curcumin 12.8318462866
MESH:D007938 Leukemia Genistein 12.8317468513 18980019
MESH:D007938 Leukemia Tretinoin 12.8317143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.3217077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.3216106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.8216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.0614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.0319077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.0316932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.5219850784 17050201 20471514 16968895 16467208
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.5217596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.5416891316 19642359 9834237 17217047 17712046 16112521 12712474 19035177 17649720 15748426 16823087 11468182 15213294 12018890 19075265 11161223 19225113 16330433 16966277 15336539 17869043 17107899 12679006 16331271 15622746
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.549834237 12679006 15748426 19029980 17217047 17506722 16766008 16891316 16140955 17361223 17712046 19225113 17368321 16935935 16331271 17301526 19035177 19075265 19642359 17339181 17649720 17107899 16823087 17294898 16788101
MESH:D015458 Leukemia, T-Cell arsenic trioxide 10.1716882451
MESH:D015458 Leukemia, T-Cell Curcumin 10.1716106398
MESH:D017880 Limb Deformities, Congenital Ethanol 7.1417676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.149224671
MESH:D008064 Lipidoses Amiodarone 3.1615342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.4416943688 17174718 11903743 16221502 16239168 21278145 17157831 17334410 11408273
MESH:D008103 Liver Cirrhosis Ethanol 9.4415289165
MESH:D008103 Liver Cirrhosis Phenobarbital 9.4421047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6118295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.8815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 11.8617525996 15931870 18210741 16097048 16248980 17481882 15338365 18054572 12667390 17976157 18251166 17869086 18418968 15052691 17640975 17900296 13678700 15818738 18376398 18395095 12632514 12609069 12898905 18277467 18395914 12389079 15673190 12445418 17557913 15925388 12445421 15959796 15876570 18472332 12958196 14748882 18156304 17922224 18412020 16011737 17714472 16638106 17805973 16136751 15730626 17698563 12546737 17708605 15893842 14512876 17721639 14716496 15650968 12649538 10355542 16033810 17565644 18472094 18317297 17761835 12632512 12666154 16192424 14620537 17944888 18420326 17631135 15370692 16116963 16015684 18705752 17823541 15057751 18006644 18339082 18166357 18187930 18481824 16027843 15362042 15123356 18263696 14716833 12741479 12586293 18429990 17766677 11481614 20821823 15996030 14724832 18205269 18279442
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 11.8618006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 11.8614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 11.8618166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 11.8617823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 11.8615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 11.8612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 11.8616248980 18397230
MESH:D008107 Liver Diseases 1,2,4-trichlorobenzene 23.841949037
MESH:D008107 Liver Diseases Acetaminophen 23.8416611625 19784758 12969438 19014921 16610002 11587558 19460945 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 23.8416246199 15830285 16964402 17285989 15720792
MESH:D008107 Liver Diseases chlorobenzene 23.841949037
MESH:D008107 Liver Diseases Curcumin 23.8416956363
MESH:D008107 Liver Diseases Hemin 23.8417173083
MESH:D008107 Liver Diseases Lindane 23.841715830
MESH:D008107 Liver Diseases Phenobarbital 23.8419363144
MESH:D008107 Liver Diseases triadimefon 23.8419363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1817207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.0016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.0014706259 16899240
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 29.8518644402 16835634
MESH:D008113 Liver Neoplasms arsenic trioxide 29.8514682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 29.8521137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 29.8519294768
MESH:D008113 Liver Neoplasms Chlordan 29.852422723
MESH:D008113 Liver Neoplasms Heptachlor 29.859544696 2422723
MESH:D008113 Liver Neoplasms Phenobarbital 29.8519812893 15975961 19482888 19073162 21047994 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 29.8520007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 29.8516984957
MESH:D008113 Liver Neoplasms triadimefon 29.8519028983
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 23.431399818 3712494 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 23.4320377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 23.4315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 23.432563599 17172636 18308698 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental systhane 23.4317178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 23.4312151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 23.4317178689
MESH:D008133 Long QT Syndrome Amiodarone 6.9515350150 17391786 11989578
MESH:D008133 Long QT Syndrome arsenic trioxide 6.9515213294
MESH:D008171 Lung Diseases Amiodarone 3.0412587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.9818516814
MESH:D008175 Lung Neoplasms alpha-Tocopherol 5.8216401635
MESH:D008175 Lung Neoplasms arsenic trioxide 5.8211798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.8218520028 18569708 17053015 20464547 18816296 20869020 20064080 6695378 20135361
MESH:D008175 Lung Neoplasms Curcumin 5.8216243823 19359593 18462866
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.8211884234 19555203
MESH:D008223 Lymphoma Curcumin 3.2418462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.2216173963
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.1316891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 8.1312929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Selenium 8.1315318939
MESH:D020149 Manganese Poisoning Estradiol 3.9919453300
MESH:D008527 Medulloblastoma Tretinoin 2.5717453147
MESH:D008545 Melanoma Curcumin 3.1517885582 18462866
MESH:D008545 Melanoma Tretinoin 3.1516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0919513568
MESH:D008569 Memory Disorders Curcumin 13.4517263510
MESH:D008569 Memory Disorders Ethanol 13.4518411066 15451040
MESH:D008569 Memory Disorders sevoflurane 13.4519212262
MESH:D008591 Meningomyelocele Tretinoin 3.9516940565
MESH:D008654 Mesothelioma Selenium 2.5815107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.8116381670
MESH:D009101 Multiple Myeloma arsenic trioxide 6.2715949261 19549372 19417148 11468182 14977855
MESH:D009101 Multiple Myeloma Curcumin 6.2719372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.4317962980
MESH:D009135 Muscular Diseases pirinixic acid 3.0316239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.4218186108
MESH:D009181 Mycoses Amiodarone 4.4012754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.1718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.4116105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.4117596541
MESH:D009203 Myocardial Infarction alpha-Tocopherol 8.3419595682
MESH:D009203 Myocardial Infarction Genistein 8.3417141266
MESH:D009203 Myocardial Infarction pirinixic acid 8.3419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 11.9916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 11.9917141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 11.9916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9917484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 8.7916624393
MESH:D009361 Neoplasm Invasiveness Curcumin 8.7918495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.263581430
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 12.998820588
MESH:D009369 Neoplasms Benzo(a)pyrene 12.9911141357
MESH:D009369 Neoplasms Lindane 12.9912807735 16818664
MESH:D009369 Neoplasms pirinixic acid 12.9917405874
MESH:D009369 Neoplasms Tretinoin 12.9916946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.0412497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2517289903
MESH:D009410 Nerve Degeneration Paraquat 3.3416893418
MESH:D009421 Nervous System Malformations bisphenol A 25.8411399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 25.8411399458 16427766
MESH:D009421 Nervous System Malformations Genistein 25.8416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 25.8414600291
MESH:D009421 Nervous System Malformations Tretinoin 25.849125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.1318462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 14.676679447
MESH:D009436 Neural Tube Defects arsenic trioxide 14.6710525206
MESH:D009436 Neural Tube Defects sodium arsenate 14.6718186108 11749123 10525206 19446573
MESH:D009436 Neural Tube Defects Tretinoin 14.679142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.4818514411
MESH:D020258 Neurotoxicity Syndromes Malathion 4.4615081274
MESH:D009765 Obesity Curcumin 4.1219297423
MESH:D009765 Obesity pirinixic acid 4.1220558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.006482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.523988306
MESH:D010018 Osteomalacia Phenobarbital 3.8817016548
MESH:D010024 Osteoporosis Curcumin 6.3218719352
MESH:D010024 Osteoporosis Genistein 6.3219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.6416169203
MESH:D010049 Ovarian Diseases bisphenol A 4.5011985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 13.0816624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Curcumin 13.0818462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 13.0819401270
MESH:D010051 Ovarian Neoplasms Genistein 13.0819005980
MESH:D010051 Ovarian Neoplasms Tretinoin 13.0816936753
MESH:D010146 Pain Acetaminophen 5.2916870215
MESH:D010146 Pain Tretinoin 5.2916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 14.2115580305
MESH:D010190 Pancreatic Neoplasms Curcumin 14.2117440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms Ethanol 14.2112384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 14.2116965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 14.2115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.017296757
MESH:D010235 Paraganglioma arsenic trioxide 3.7119927285
MESH:D010300 Parkinson Disease Paraquat 2.6212911755 16510128 11124998 15824117 11181820 16140633 15451049 11445065
MESH:D010302 Parkinson Disease, Secondary Paraquat 3.9616190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7512520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.976228378
MESH:D010954 Plasmacytoma Selenium 4.3915087411
MESH:D011014 Pneumonia Paraquat 3.9712504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1018163543
MESH:D011164 Porphyrias 1,2,4-trichlorobenzene 6.316636202
MESH:D017094 Porphyrias, Hepatic fomesafen 7.4112758057
MESH:D011230 Precancerous Conditions Phenobarbital 3.212563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 7.8910548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.8911222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.1020887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.1020887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.3119131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.3117292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.3116740699
MESH:D011471 Prostatic Neoplasms Curcumin 2.3118156803 18226269 18769126 10851300 12497104 15129424 11398177
MESH:D011471 Prostatic Neoplasms Estradiol 2.3116740699
MESH:D011471 Prostatic Neoplasms Genistein 2.3115256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Heptachlor 2.3112661182
MESH:D011471 Prostatic Neoplasms Lindane 2.3112661182 14688026
MESH:D011507 Proteinuria Tretinoin 3.1616636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.8315861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.0012752131
MESH:D011625 Pterygium Tretinoin 4.3016723453
MESH:D011629 Puberty, Precocious bisphenol A 4.3010548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.1019168576
MESH:D011657 Pulmonary Eosinophilia alpha-Tocopherol 5.4914606601
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.1412832656 11597910 12490602
MESH:D011658 Pulmonary Fibrosis Paraquat 5.1417997886 16324872
MESH:D015427 Reperfusion Injury pirinixic acid 2.1319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 7.7818379247 10666014
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 7.7811700416
MESH:D012135 Respiratory Sounds Malathion 8.6017119214 11874814
MESH:D012135 Respiratory Sounds Paraquat 8.6011874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3718990726
MESH:D012140 Respiratory Tract Diseases Malathion 5.0317119214
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 7.693692021
MESH:D012162 Retinal Degeneration Paraquat 7.6916458197
MESH:D012174 Retinitis Pigmentosa alpha-Tocopherol 3.8216849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6516116481 16283617
MESH:D012509 Sarcoma Curcumin 3.6918462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.0516646077
MESH:D012512 Sarcoma, Ewing's Dactinomycin 9.0514601052
MESH:D012640 Seizures Ethanol 8.089754883
MESH:D012640 Seizures Lindane 8.0815475178 12842176 7539098
MESH:D012640 Seizures Phenobarbital 8.083137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.336407741
MESH:D018805 Sepsis Curcumin 3.6818389075
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.6018724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 7.9310029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 7.9316192470
MESH:D012878 Skin Neoplasms Tretinoin 7.9316467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.4516709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.2317007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.232093021 20155912
MESH:D013274 Stomach Neoplasms Ethanol 4.2318456281
MESH:D013274 Stomach Neoplasms Tretinoin 4.2317261132
MESH:D013276 Stomach Ulcer Amiodarone 9.6718087811
MESH:D013276 Stomach Ulcer Curcumin 9.6716631530 19188055
MESH:D013276 Stomach Ulcer Ethanol 9.6716755016 17189318 17918041 9211565 11906479 9562338
MESH:D019966 Substance-Related Disorders bisphenol A 3.5016045194 16684133
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.839754883
MESH:D013610 Tachycardia Amiodarone 3.8311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.7319225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7415669648
MESH:D013959 Thyroid Diseases Amiodarone 10.4019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.4012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 18.533712494 6582329 1399818 7505956 6587162
MESH:D013964 Thyroid Neoplasms arsenic trioxide 18.5319014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 18.531399818
MESH:D013964 Thyroid Neoplasms Tretinoin 18.5316026305 17045167
MESH:D013964 Thyroid Neoplasms triadimefon 18.5317178689
MESH:D013971 Thyrotoxicosis Amiodarone 4.3819584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.1919048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.3616051514
MESH:D016171 Torsades de Pointes Amiodarone 8.6417467628 11989578
MESH:D016171 Torsades de Pointes arsenic trioxide 8.6415213294
MESH:D014376 Tuberculosis Tretinoin 2.9116040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 10.178074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 10.1712973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.1717053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 10.1718593936
MESH:D014565 Urogenital Neoplasms Curcumin 4.7818462866
MESH:D014581 Urticaria Acetaminophen 2.5310982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.2616129372
MESH:D014591 Uterine Diseases bisphenol A 4.5114652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8414692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.1116752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1015869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.5916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7515886252
MESH:D009396 Wilms Tumor Tretinoin 3.5616287080
Pathway ID Pathway Name
KEGG:00260 Glycine, serine and threonine metabolism
KEGG:01100 Metabolic pathways
REACT:9431 Metabolism of porphyrins
KEGG:00860 Porphyrin and chlorophyll metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24688
    • Releated gene ID Related gene Name
    PA378NR1I2
    No data
    Releated drug ID Related drug Name
    PA449789glycine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00114 - Pyridoxal Phosphate Dietary supplement;Micronutrient;Vitamin B Complex
    DB00145 - Glycine Dietary supplement;Micronutrient;Non-Essential Amino Acids;Glycine Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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