AutismKB 2.0

Annotation Detail for ETS1


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Basic Information Top
Gene Symbol:ETS1 ( ETS-1,EWSR2,FLJ10768 )
Gene Full Name: v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
Band: 11q24.3
Quick LinksEntrez ID:2113; OMIM: 164720; Uniprot ID:ETS1_HUMAN; ENSEMBL ID: ENSG00000134954; HGNC ID: 3488
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04320Dorso-ventral axis formation
hsa05211Renal cell carcinoma
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200030HIF-2-alpha transcription factor network
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200005BCR signaling pathway
200130C-MYB transcription factor network
200066Angiopoietin receptor Tie2-mediated signaling
200172HIF-1-alpha transcription factor network
200018IL4-mediated signaling events
200118AP-1 transcription factor network
200192Signaling events mediated by focal adhesion kinase
Pathway IDPathway Name
P00056VEGF signaling pathway
P00005Angiogenesis
P00047PDGF signaling pathway
P04393Ras Pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2074Asthma
Desease Name
Celiac Disease
systemic lupus erythematosus
IMMUNE
Desease Name
Celiac disease
Systemic lupus erythematosus
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ETS1 mRNAincreases expression 16788091
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of ETS1 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of ETS1 mRNAaffects expression 17562736
C109238 acyline acyline results in increased expression of ETS1 mRNAincreases expression 17510436
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ETS1 mRNAaffects expression 16483693
C004984 apocarotenal apocarotenal results in decreased expression of ETS1 mRNAdecreases expression 17034753
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ETS1 mRNAdecreases expression 20458559
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of ETS1 mRNAincreases expression 18687144
D001374 Azacitidine Azacitidine promotes the reaction [ETS1 protein binds to KIR2DL2 promoter]affects binding|increases reaction 18945643
D001374 Azacitidine Azacitidine promotes the reaction [ETS1 protein binds to KIR2DL4 promoter]affects binding|increases reaction 18945643
C006780 bisphenol A bisphenol A results in increased expression of ETS1 mRNAincreases expression 18180321
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of ETS1 mRNAdecreases expression 17553608
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ETS1 mRNAdecreases expression 12419474
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ETS1 mRNAaffects cotreatment|decreases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ETS1 mRNAdecreases expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of ETS1 mRNAincreases expression 20106945
C014347 decitabine decitabine results in increased expression of ETS1 mRNAincreases expression 19027835
C014347 decitabine decitabine results in increased expression of ETS1 proteinincreases expression 19027835
D004041 Dietary Fats Dietary Fats results in increased expression of ETS1 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ETS1 mRNAaffects cotreatment|decreases expression 20360939
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ETS1 mRNAdecreases expression 17557909
D005419 Flavonoids Flavonoids results in increased expression of ETS1 mRNAincreases expression 15465739
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of ETS1 mRNA]affects reaction|decreases expression 15016801
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of ETS1 mRNAincreases expression 12634122
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of ETS1 mRNAincreases expression 12832660
C041786 palm oil palm oil results in increased expression of ETS1 mRNAincreases expression 18042831
D010936 Plant Extracts Plant Extracts results in increased expression of ETS1 mRNAincreases expression 15465739
C025299 polyphenols polyphenols results in increased expression of ETS1 mRNAincreases expression 15465739
C052785 rebamipide rebamipide results in increased expression of ETS1 mRNAincreases expression 15104358
C017947 sodium arsenite sodium arsenite results in increased expression of ETS1 mRNAincreases expression 12760830
C017947 sodium arsenite sodium arsenite results in decreased expression of ETS1 mRNAdecreases expression 16322246
D013467 Sulindac Sulindac results in increased expression of ETS1 mRNAincreases expression 11906190
D014212 Tretinoin Tretinoin results in increased expression of ETS1 mRNAincreases expression 16211290
D014635 Valproic Acid Valproic Acid results in increased expression of ETS1 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of ETS1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.1814745880
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.188875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6519490988
MESH:D000138 Acidosis Ammonium Chloride 3.2518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6317505938
MESH:D058186 Acute Kidney Injury Sulindac 4.047897758
MESH:D000230 Adenocarcinoma arsenic trioxide 9.5111798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.5114692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.5117638652
MESH:D000230 Adenocarcinoma Sulindac 9.5111910360
MESH:D000236 Adenoma Diethylnitrosamine 6.4510737359 6695378
MESH:D000236 Adenoma Sulindac 6.4510223192
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.5919052882 18056438 19061943 16434500 17620307 17162532
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.3315623613 11874996 12394442 11535846 16460482 17611924 19003578
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5916712894 17306315
MESH:D000505 Alopecia Tretinoin 3.3715955085
MESH:D000544 Alzheimer Disease Plant Extracts 2.9516962711
MESH:D000550 Amblyopia Valproic Acid 4.9217688650
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9110965797
MESH:D000740 Anemia Fluorouracil 3.4517963324 16511603 15504547
MESH:D000799 Angioedema Acetaminophen 3.5310982225
MESH:D001008 Anxiety Disorders Valproic Acid 8.0517497229
MESH:D001008 Anxiety Disorders vinclozolin 8.0519015723
MESH:D001161 Arteriosclerosis Dietary Fats 8.9015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.9011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.2215885639
MESH:D001169 Arthritis, Experimental Plant Extracts 11.2214686799
MESH:D001169 Arthritis, Experimental Tretinoin 11.2216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1916292516
MESH:D001249 Asthma Tretinoin 2.2516456186
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8520603192 17157402 15238991 18177632 18316065 18940202 17507914 18775368 18396377 17688650 18558336 16609825 19460635 18985861 19232924
MESH:D001471 Barrett Esophagus Tretinoin 4.1116935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.9217594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.2516206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.2516197459 16206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.208888407
MESH:D001862 Bone Resorption bisphenol A 3.5911985600
MESH:D001913 Bowen's Disease Sulindac 5.0411207687
MESH:D002545 Brain Ischemia Plant Extracts 4.4216041641
MESH:D001943 Breast Neoplasms bisphenol A 3.5517123778
MESH:D001943 Breast Neoplasms decitabine 3.5518320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 3.5520435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.5517474063
MESH:D001943 Breast Neoplasms Fluorouracil 3.5519217205 18357371 16110121 15136595 18608205 16557594 16595493
MESH:D001943 Breast Neoplasms Sulindac 3.5516642371
MESH:D001943 Breast Neoplasms Tretinoin 3.5516873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2816813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0411589617
MESH:D002057 Burns, Chemical Plant Extracts 5.029625245
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4810355542 16050911 16227642 16011737 15673190 18705752 15700767 3786805 15721981 16097048 16124888 16192424
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3516051944
MESH:D002277 Carcinoma Fluorouracil 3.3217121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8416168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.953084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 15.9515553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 15.9518788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 15.9516698587 17055752 17978847 18210153 18978308 16569478 17138121 19052882 19394651 20727157 19335982 19701751 20007298 3084413 18665156 20214788 10737359 18506893 19519916 10672840 20084675 19208518 16540662 16935385 16807293 17761372 20935162 18393292 11831363 19919837 18971187 18691550 17173139 20514400 19822196 19383236 16288022 16328049 19418558 18056438 3581430 18788625 16830150 20432363 19171122 20512989 16779866 18494052 20524982 16681979 21159647 16878318 18785209 16502159 17428255 20101231 19539802 19107877 17162532
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 15.9516332177 16799960 17045692 18930000 17088986 17971768
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 15.9518834353
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 15.9517306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 15.951917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.6817123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5619014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8718695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8512490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.0219215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.0218986760 16757204 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.0218572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.0216096774 16051514
MESH:D006332 Cardiomegaly Plant Extracts 3.6317645561
MESH:D002386 Cataract Acetaminophen 6.6210977129
MESH:D002386 Cataract Tretinoin 6.6217460283
MESH:D002446 Celiac Disease marker/mechanism 20190752
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.3312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.3317174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 14.332727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.3320056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2816129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5920734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.4319052882
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.8812912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 12.2316629650 12927374 18590720 18164287 19486331 15500046 7624871 15913567
MESH:D002779 Cholestasis Cyclosporine 12.2319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.2311677210 17110522 16105132 15861022 17681005 17333356 16919318
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.5410220858 19407337
MESH:D002822 Choriocarcinoma Tretinoin 4.8416461808
MESH:D002972 Cleft Palate Tretinoin 2.549407595
MESH:D003092 Colitis Tretinoin 3.4017035595
MESH:D003110 Colonic Neoplasms decitabine 7.8417616700
MESH:D003110 Colonic Neoplasms Fluorouracil 7.8415001691 17018589 16510598 17016597 17725105 17169374 17172411 18772588 17287894 16340194
MESH:D003110 Colonic Neoplasms polyphenols 7.8416293270
MESH:D003110 Colonic Neoplasms Sulindac 7.8412902858 12458338
MESH:D015179 Colorectal Neoplasms arsenic trioxide 6.1420501625
MESH:D015179 Colorectal Neoplasms Azacitidine 6.1419934284
MESH:D015179 Colorectal Neoplasms decitabine 6.1418981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 6.1417454858 20501625 18802399 18448328 18383874 14970324 17695437 18949393 16282729 15289873 15148649 17401013 16524972 17094418 16303861 16391804 18509181 18288408 17594712 16331619 17016601 17255274
MESH:D015179 Colorectal Neoplasms Sulindac 6.1418059344 10666051 11197048 11076880
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.6410525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.649211117 10589399 9125849 17551590 16925845 8800419 9142499 9664655 14991402 9224671
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.6416575769 8888407 17688650
MESH:D003456 Cryptorchidism vinclozolin 4.0514966744
MESH:D007644 Darier Disease Fluorouracil 4.4816733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8115213294
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1220387270
MESH:D003928 Diabetic Nephropathies Plant Extracts 4.1519706694
MESH:D003930 Diabetic Retinopathy Sulindac 4.8812861449 17621415
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 13.9820133375 17522070 18289764 7624871
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 13.9814725611 19370779 16781746 10774834 11529661 14550746 11743745 2444490 12705907 18713872 11739529 12540782 14986274 12153990 11421492 19923254 11461765 16393943 17522070 12392966 19085960 10663392 16177239 16485898 17906064 15619225 11834606 17562736 16109766 10915739 12594235 19739265 16081117 18071297 19164858 19420014 19416960 15968718 11287661 12958197 16227642
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 13.9811566570 7440962 7120509 9327722 15027814 2869522 10092053 4309450 15998439 16227642 7179309 21278145 3786805 17522070 6623471 10915739 6884620 19336974 19085960 16177239 15968718 3732212
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 13.9819107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 13.9819370779
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 13.981733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7819426721
MESH:D050171 Dyslipidemias Dietary Fats 3.2318367378
MESH:D004421 Dystonia Valproic Acid 3.761851702
MESH:D004487 Edema Plant Extracts 3.5512787963
MESH:D004489 Edema, Cardiac Tretinoin 4.1518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9012538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8019294695
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9116569247
MESH:D004715 Endometriosis Sulindac 4.2115652904
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.3715268973
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.8517275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.603922381 16628512
MESH:D004827 Epilepsy Plant Extracts 6.4419439326 19700373
MESH:D004827 Epilepsy Valproic Acid 6.4418234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.336426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.997750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.753659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8016302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.9112903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.9116481741 15173087 16785472 16337965 17638652
MESH:D004938 Esophageal Neoplasms Sulindac 6.9112235107
MESH:D005124 Eye Abnormalities Tretinoin 3.359664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 38.4915073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 38.4912631006 19224547 12795759 61145 16239168 16045604 15959796 17595544
MESH:D005234 Fatty Liver Cyclosporine 38.4919224547
MESH:D005234 Fatty Liver Dietary Fats 38.4917967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 38.4921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 38.4915345470
MESH:D005234 Fatty Liver Plant Extracts 38.4915975614
MESH:D005234 Fatty Liver Valproic Acid 38.4914986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 4.5716575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.848888407 18558336
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.1714745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 4.8219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 18.6618705752
MESH:D005355 Fibrosis Cyclosporine 18.6612639820 12168785
MESH:D005355 Fibrosis Dietary Fats 18.6618296743
MESH:D005355 Fibrosis Tretinoin 18.6617994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9716904648
MESH:D005756 Gastritis Acetaminophen 3.3616983495
MESH:D005764 Gastroesophageal Reflux Sulindac 4.7111910360
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6216973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9816417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3716452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.918708960
MESH:D005909 Glioblastoma Tretinoin 2.8117312396
MESH:D005910 Glioma Fluorouracil 2.7416145905
MESH:D006258 Head and Neck Neoplasms decitabine 11.7719215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 11.7718337622 15102660 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 11.7716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8416084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.7314991402 9664655
MESH:D006333 Heart Failure Plant Extracts 3.6818097624
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1115720958
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 8.6818590720
MESH:D006505 Hepatitis Carbon Tetrachloride 8.6819110552 19900420
MESH:D006561 Herpes Simplex Plant Extracts 4.3210715843
MESH:D015658 HIV Infections Plant Extracts 3.5212878215
MESH:D006689 Hodgkin Disease sodium arsenite 2.9012676792
MESH:D019584 Hot Flashes Plant Extracts 4.4316566672 17454163 14716179
MESH:D006849 Hydrocephalus Valproic Acid 4.5617688650
MESH:D006930 Hyperalgesia Acetaminophen 6.8216870215
MESH:D006930 Hyperalgesia Tretinoin 6.8216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2216899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3221332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2616778211
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.2016484555
MESH:D006949 Hyperlipidemias Dietary Fats 8.5021332399
MESH:D006949 Hyperlipidemias Plant Extracts 8.5015268973 15975614
MESH:D006973 Hypertension Cyclosporine 1.9810903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7815338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1812013081
MESH:D007248 Infertility, Male decitabine 14.3617581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 14.3617937319
MESH:D007248 Infertility, Male sodium arsenite 14.3615346721 12646999
MESH:D007248 Infertility, Male vinclozolin 14.3616467254
MESH:D007249 Inflammation Dietary Fats 17.8520412841
MESH:D007249 Inflammation Diethylnitrosamine 17.8518785209
MESH:D007249 Inflammation Flavonoids 17.8517296493
MESH:D007249 Inflammation Plant Extracts 17.8515997105 12787963 19332304 16366677
MESH:D007249 Inflammation polyphenols 17.8516366677
MESH:D007249 Inflammation Sulindac 17.853291741
MESH:D007333 Insulin Resistance bisphenol A 6.8216393666
MESH:D007333 Insulin Resistance Dietary Fats 6.8218457598 11836018
MESH:D007410 Intestinal Diseases rebamipide 9.1911686837
MESH:D007410 Intestinal Diseases Tretinoin 9.1917994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 15.0510783313
MESH:D007414 Intestinal Neoplasms Plant Extracts 15.0512584176 12351151 12628509
MESH:D007414 Intestinal Neoplasms Sulindac 15.0512351151 12663524 12628509 10223192 10213222 12584176
MESH:D007417 Intestinal Polyps Sulindac 4.7012394442 11245490
MESH:D007569 Jaw Abnormalities Tretinoin 3.6217551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1315604871
MESH:D007674 Kidney Diseases Acetaminophen 12.9815629191 12587719
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 12.9815369732
MESH:D007674 Kidney Diseases Cyclosporine 12.9818776723 10903974 8314463
MESH:D007674 Kidney Diseases sodium arsenite 12.9820008137
MESH:D007680 Kidney Neoplasms Cyclosporine 6.5712371664
MESH:D007680 Kidney Neoplasms Fluorouracil 6.5716985049
MESH:D007938 Leukemia arsenic trioxide 13.7115070760
MESH:D007938 Leukemia Azacitidine 13.7119148494
MESH:D007938 Leukemia decitabine 13.7119235587 18980019
MESH:D007938 Leukemia Tretinoin 13.7117143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 20.5619077051
MESH:D007951 Leukemia, Myeloid Azacitidine 20.5619077051
MESH:D007951 Leukemia, Myeloid decitabine 20.5619117987 17236224 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 20.5616482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 11.0216968895 17050201 16467208 19850784 20471514
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 11.0218720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute decitabine 11.0219010910 17679729 18704418 18460780 19387464 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 11.0219850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 11.0216294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1518055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.9019299654
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 11.6711161223 17217047 19075265 16112521 12679006 17649720 17869043 16891316 16331271 19035177 15748426 12712474 16966277 15213294 15622746 17107899 12018890 16823087 19225113 19642359 16330433 9834237 15336539 17712046 11468182
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 11.6716766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 11.679834237 17217047 19075265 15748426 19642359 12679006 16823087 16140955 17339181 17506722 16766008 16935935 16331271 17301526 17107899 17368321 17712046 19225113 17361223 16891316 17294898 19029980 19035177 17649720 16788101
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0616882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4216417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.099224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 14.3811903743 17157831 11408273 16221502 16943688 21278145 17174718 16239168 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 14.3818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.3818665156 19638242 18522880 18407596 20032147
MESH:D008103 Liver Cirrhosis Plant Extracts 14.3817157831
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.0312468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4215123356 17721639 17900296 18395914 15959796 10355542 17976157 15876570 17766677 12546737 14716833 17557913 18166357 13678700 12632512 12898905 17944888 18412020 18263696 18205269 17525996 15818738 16033810 18279442 17481882 14620537 18472094 15338365 16097048 15925388 16192424 15931870 18429990 17922224 12445421 18054572 15996030 12445418 12667390 18376398 18395095 12632514 12649538 18277467 12609069 16015684 16027843 18251166 15057751 15730626 15052691 17708605 15362042 17714472 20821823 16248980 17869086 17761835 14724832 14716496 17640975 15673190 18420326 15370692 12586293 14512876 18339082 17823541 18317297 12666154 18705752 18210741 15650968 17805973 18418968 17698563 16136751 12389079 18472332 18006644 17565644 16638106 14748882 12958196 17631135 16011737 15893842 12741479 18187930 18156304 18481824 16116963 11481614
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 3.4215479170
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4216248980 18397230
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 18.0717184895
MESH:D008107 Liver Diseases Acetaminophen 18.0712587719 19460945 11587558 19784758 16610002 12969438 16611625 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 18.0716964402 17285989 15720792 16246199 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 18.0717034775
MESH:D008107 Liver Diseases Plant Extracts 18.0717034775
MESH:D008107 Liver Diseases polyphenols 18.0716698588
MESH:D008107 Liver Diseases Sulindac 18.0716867024 14986274
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8615123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.5216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.5216899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 16.3914682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.3919294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 16.3916942905 18978307 19256749 15885732 20492335 20118626 19551842 20501860 19427195 21278145 2422723 19499222 2862719 18754104 19090486 20137499 20583210 19638242 21047994 19254457 19996281 18644402 19255062 19426721 20434301 19294768 19690152 15175105 20405173 18648771 12771043 20101389 21167192 19812893 21071580 20452335 9163691 18977376 19833225 19073162 12112319 19642983 10737359 19850985
MESH:D008113 Liver Neoplasms Fluorouracil 16.3917045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms Plant Extracts 16.3919168119
MESH:D008113 Liver Neoplasms sodium arsenite 16.3916712894 15276417
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 8.7620377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 8.7612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 8.7616842330 18775883 3124819 18544905 18308698 18079962 17942915 16267830 18093689 17174075 19126423 21159647 2563599 19009564 17854601 19539802 18282651 19004024 9362446 19519916 18253720 18164116
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1215213294
MESH:D008171 Lung Diseases sodium arsenite 2.9719095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.9517228818
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.7217365036
MESH:D008175 Lung Neoplasms arsenic trioxide 10.0511798837 19825857
MESH:D008175 Lung Neoplasms Azacitidine 10.0521224363
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.0520970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Fluorouracil 10.0515246190
MESH:D008175 Lung Neoplasms Plant Extracts 10.0520869020
MESH:D008175 Lung Neoplasms sodium arsenite 10.0517306315 15276417 17077188 19931552 16712894
MESH:D008175 Lung Neoplasms Sulindac 10.0519359593 15713900
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4815086387
MESH:D008180 Lupus Erythematosus, Systemic marker/mechanism 19838193
MESH:D008223 Lymphoma decitabine 3.2019470736
MESH:D008527 Medulloblastoma Tretinoin 2.6617453147
MESH:D008545 Melanoma decitabine 6.8416505122 17785578
MESH:D008545 Melanoma sodium arsenite 6.8419082730 16487513
MESH:D008545 Melanoma Sulindac 6.8416642371
MESH:D008545 Melanoma Tretinoin 6.8416752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2619513568
MESH:D008591 Meningomyelocele Tretinoin 4.1216940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0616166281 16966607 18303189
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4716801185
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.5817671175
MESH:D008881 Migraine Disorders Valproic Acid 2.9718765137 18803445
MESH:D009006 Monosomy Azacitidine 5.7719299654
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4018986760 16757204
MESH:D009101 Multiple Myeloma arsenic trioxide 10.9711468182 19549372 19417148 14977855 15949261
MESH:D009101 Multiple Myeloma Azacitidine 10.9719549372 18443271
MESH:D009101 Multiple Myeloma decitabine 10.9718172295
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.758888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 21.1816105982 16882451
MESH:D009190 Myelodysplastic Syndromes Azacitidine 21.1819805378 17611569 18720364 17596541
MESH:D009190 Myelodysplastic Syndromes decitabine 21.1819010910 18608210 19157545 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 21.1817596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 21.1817596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6716624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.443581430 9029167
MESH:D009369 Neoplasms decitabine 10.6119470736 17925555 19116145
MESH:D009369 Neoplasms Fluorouracil 10.6118239605 18600527 16928823
MESH:D009369 Neoplasms sodium arsenite 10.6111559025
MESH:D009369 Neoplasms Tretinoin 10.6116946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3720056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0319348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 8.8111399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 8.819125849
MESH:D009436 Neural Tube Defects arsenic trioxide 15.6810525206
MESH:D009436 Neural Tube Defects sodium arsenite 15.6812854658
MESH:D009436 Neural Tube Defects Tretinoin 15.689142499
MESH:D009436 Neural Tube Defects Valproic Acid 15.6816359493 8888407
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.8817168769
MESH:D019636 Neurodegenerative Diseases Acetaminophen 12.6718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 12.6720387270
MESH:D019636 Neurodegenerative Diseases Sulindac 12.6717266991 16850258
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8020387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2316436463
MESH:D009765 Obesity Dietary Fats 4.6517217161 18674790 21332399 18457598 20132043 16723640 11836018 19632207 20518802
MESH:D009765 Obesity Plant Extracts 4.6519056576 20132043
MESH:D010049 Ovarian Diseases bisphenol A 4.6811985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.4519769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms decitabine 10.4519331143 19259094
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.4517306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 10.4516936753
MESH:D010146 Pain Acetaminophen 9.8816870215
MESH:D010146 Pain Sulindac 9.883291741
MESH:D010146 Pain Tretinoin 9.8816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 18.9915580305
MESH:D010190 Pancreatic Neoplasms decitabine 18.9919294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 18.9916540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 18.9916500647 16929163 15113037 19003803
MESH:D010190 Pancreatic Neoplasms Sulindac 18.9911504793 16820089
MESH:D010190 Pancreatic Neoplasms Tretinoin 18.9915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4011578682
MESH:D010212 Papilloma Plant Extracts 4.1915173996 16517061
MESH:D010235 Paraganglioma arsenic trioxide 3.8819927285
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 5.5420133375
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.1911550810
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.5910923243
MESH:D011230 Precancerous Conditions Cyclosporine 8.0812371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.082563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 14.5410548101
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 14.5420603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.5418220299 18042343 19015723
MESH:D055728 Primary Myelofibrosis decitabine 4.4217616702
MESH:D011469 Prostatic Diseases vinclozolin 4.6218220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.9320887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8819131511
MESH:D011471 Prostatic Neoplasms Azacitidine 1.8818324645
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8818626508 19082440
MESH:D011471 Prostatic Neoplasms Plant Extracts 1.8817804756 14666653
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8816039940
MESH:D011472 Prostatitis vinclozolin 4.6218629315
MESH:D011507 Proteinuria Tretinoin 3.3216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0015861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.2312752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D011625 Pterygium Tretinoin 4.4816723453
MESH:D011629 Puberty, Precocious bisphenol A 4.4710548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9115814490 17365031 17322281 17975199
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7518722050 18286688 16160472 15538739
MESH:D015427 Reperfusion Injury marker/mechanism 16526316
MESH:D012208 Rhabdomyosarcoma decitabine 16.8619155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 16.8616283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 16.8619155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6716646077
MESH:D012559 Schizophrenia Valproic Acid 2.0319110320 15737665
MESH:D012640 Seizures Valproic Acid 2.5414763951 15475178 1511512 11738929 11044598 16876388 3137016 17978042
MESH:D012878 Skin Neoplasms Plant Extracts 12.4016517061 15173996
MESH:D012878 Skin Neoplasms sodium arsenite 12.4019524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.408532709
MESH:D012878 Skin Neoplasms Tretinoin 12.4016467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6316709447
MESH:D016135 Spinal Dysraphism sodium arsenite 8.7612854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.7619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2312833885
MESH:D013272 Stomach Diseases rebamipide 4.9616184426
MESH:D013274 Stomach Neoplasms arsenic trioxide 7.8517007042
MESH:D013274 Stomach Neoplasms decitabine 7.8519037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 7.8518456281
MESH:D013274 Stomach Neoplasms Fluorouracil 7.8515786421 18396642 19084572 16424979 17172411 17522103 16951190 18567086 17498489 19015929
MESH:D013274 Stomach Neoplasms rebamipide 7.8515993841
MESH:D013274 Stomach Neoplasms Tretinoin 7.8517261132
MESH:D013276 Stomach Ulcer Plant Extracts 3.6315255614 18193104 18237397 12787963 17135157
MESH:D019966 Substance-Related Disorders bisphenol A 3.6716045194 16684133
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 12.2217997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 12.2217997062
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.4920133375
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8915669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 15.2019014326
MESH:D013964 Thyroid Neoplasms decitabine 15.2017967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.207505956
MESH:D013964 Thyroid Neoplasms Tretinoin 15.2016026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 8.9416280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.9416051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6515213294
MESH:D014178 Translocation, Genetic Valproic Acid 4.9217262798
MESH:D014376 Tuberculosis Tretinoin 3.0416040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.213119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.6612845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms decitabine 7.6617616700 19087683
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.6611723127 17306315 16452187 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.348888407
MESH:D014581 Urticaria Acetaminophen 2.6910982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.3116803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.3111813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.3116129372
MESH:D014591 Uterine Diseases bisphenol A 4.6914652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.6914692618
MESH:D014594 Uterine Neoplasms Sulindac 8.6918645019
MESH:D014604 Uveal Neoplasms decitabine 11.7717785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.7716752155
MESH:D014605 Uveitis Cyclosporine 3.671336536
MESH:D014652 Vascular Diseases sodium arsenite 4.1117056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2614671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.4418097624
MESH:D020257 Ventricular Remodeling Plant Extracts 5.0018097624
MESH:D014820 Vitiligo Tretinoin 3.7616761959
MESH:D015430 Weight Gain Dietary Fats 3.4816723640
MESH:D009396 Wilms Tumor Tretinoin 3.7116287080
MESH:D014947 Wounds and Injuries Plant Extracts 4.0020213670 19894650
MESH:D014985 Xerophthalmia Cyclosporine 4.1317120751
Pathway ID Pathway Name
KEGG:04320 Dorso-ventral axis formation
KEGG:05200 Pathways in cancer
KEGG:05211 Renal cell carcinoma
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27902
    • No data
    Releated disease ID Related disease Name
    PA445204Ovarian Neoplasms
    Releated drug ID Related drug Name
    PA448976choline
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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