AutismKB 2.0

Annotation Detail for ETV1


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Basic Information Top
Gene Symbol:ETV1 ( DKFZp781L0674,ER81,MGC104699,MGC120533,MGC120534 )
Gene Full Name: ets variant 1
Band: 7p21.2
Quick LinksEntrez ID:2115; OMIM: 600541; Uniprot ID:ETV1_HUMAN; ENSEMBL ID: ENSG00000006468; HGNC ID: 3490
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200135p38 signaling mediated by MAPKAP kinases
No data
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Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
H00035Ewing's sarcoma
Cancers of soft tissues and bone
Desease IDDesease Name
1831Prostate cancer
1944Breast cancer
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of ETV1 mRNAincreases expression 20713471
D004958 Estradiol Estradiol results in decreased expression of ETV1 mRNAdecreases expression 20068009
C056507 gemcitabine gemcitabine results in increased expression of ETV1 mRNAincreases expression 17039268
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of ETV1 mRNAincreases expression 20713471
D011374 Progesterone Progesterone results in increased expression of ETV1 mRNAincreases expression 18070364
D014212 Tretinoin Tretinoin results in decreased expression of ETV1 mRNAdecreases expression 16604517
C025643 vinclozolin vinclozolin affects the expression of ETV1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1511473722
MESH:D000236 Adenoma Methylcholanthrene 3.6410545420 6695378
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D001008 Anxiety Disorders vinclozolin 3.8619015723
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D050197 Atherosclerosis Methylcholanthrene 3.6011922910
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8916206674 16197459
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7817868700
MESH:D001930 Brain Injuries Progesterone 4.6215665606 15845082 15380490
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 3.0811921183
MESH:D001943 Breast Neoplasms Estradiol 3.0819861407 12948864 18497071 17289903 14630087 16675129 17018787 17261762
MESH:D001943 Breast Neoplasms gemcitabine 3.0817039268 18382427
MESH:D001943 Breast Neoplasms Methylcholanthrene 3.0817474063
MESH:D001943 Breast Neoplasms Progesterone 3.0815562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tretinoin 3.0816443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002277 Carcinoma Methylcholanthrene 4.1910545420
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.111917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3516096774 16051514
MESH:D002386 Cataract Tretinoin 3.2417460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.5518566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 7.5516192471
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tretinoin 2.769407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8317551590 8800419 10589399 9211117 16925845 9664655 9142499 9224671 14991402 9125849
MESH:D003456 Cryptorchidism vinclozolin 4.6714966744
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.8517187935
MESH:D004489 Edema, Cardiac Tretinoin 4.9118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.1117692515
MESH:D016889 Endometrial Neoplasms Estradiol 7.9811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 7.9816569247
MESH:D004715 Endometriosis Progesterone 4.0316134523
MESH:D005124 Eye Abnormalities Tretinoin 3.789664655 16938888
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.3410962813 14633661
MESH:D005355 Fibrosis Tretinoin 3.8717994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.3316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.7416417039
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0214991402 9664655
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006930 Hyperalgesia Tretinoin 3.4316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7615869954
MESH:D007248 Infertility, Male vinclozolin 3.2116467254
MESH:D007249 Inflammation Progesterone 2.7215869954
MESH:D007333 Insulin Resistance Estradiol 3.1316393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1817551590 15992940
MESH:D007674 Kidney Diseases Estradiol 2.7215618244
MESH:D007680 Kidney Neoplasms Estradiol 3.2115610895
MESH:D007938 Leukemia Tretinoin 2.8917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1119850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3217361223 19225113 16891316 16788101 17107899 17301526 17712046 19029980 17649720 15748426 19642359 16331271 16823087 12679006 17294898 16766008 17339181 17368321 9834237 16935935 19035177 19075265 17217047 17506722 16140955
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1316417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5316248980 18397230
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 3.43598648 1399818
MESH:D008175 Lung Neoplasms Methylcholanthrene 2.419230183 20512841 1399818 11893704 7750092 6695378 20970405 21163286 16337739 17909032 16271038 10545420 15390079
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 11.0911921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 11.0917203775 11408345 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 11.0911408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2217596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009369 Neoplasms Tretinoin 2.5216594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Estradiol 10.7911399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 10.799125849
MESH:D009436 Neural Tube Defects Tretinoin 3.229142499
MESH:D010051 Ovarian Neoplasms Estradiol 8.3119401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.3116525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 8.3116936753
MESH:D010146 Pain Tretinoin 3.1316870215
MESH:D010190 Pancreatic Neoplasms gemcitabine 5.9416929163 18992248 17440100 18383843 11504793
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.9415976015
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2918042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.3318220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17173048 17671502
MESH:D011471 Prostatic Neoplasms Estradiol 3.0416740699
MESH:D011472 Prostatitis vinclozolin 5.3318629315
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9318045962
MESH:D012878 Skin Neoplasms Tretinoin 2.7216467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.6815862959 16503802
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2316026305 17045167
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
No data
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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