AutismKB 2.0

Annotation Detail for ALAS2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ALAS2 ( ALAS-E,ALASE,ANH1,ASB,FLJ93603,XLDPP,XLSA )
Gene Full Name: aminolevulinate, delta-, synthase 2
Band: Xp11.21
Quick LinksEntrez ID:212; OMIM: 301300; Uniprot ID:HEM0_HUMAN; ENSEMBL ID: ENSG00000158578; HGNC ID: 397
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5920heme biosynthesis II
PWY-5189tetrapyrrole biosynthesis II
Pathway IDPathway Name
hsa00860Porphyrin and chlorophyll metabolism
hsa01100Metabolic pathways
hsa00260Glycine, serine and threonine metabolism
Pathway IDPathway Name
Metabolism of porphyrins
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Anemia, sideroblastic, X-linked
Protoporphyria, erythropoietic, X-linked dominant
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049325 1,2-dithiol-3-thione 1,2-dithiol-3-thione results in decreased expression of ALAS2 mRNAdecreases expression 15302862
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ALAS2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ALAS2 mRNAaffects expression 15606129
17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of ALAS2 mRNAincreases expression 20458559
D016589 Astemizole Astemizole results in increased expression of ALAS2 mRNAincreases expression 20221588
D001554 Benzene Benzene results in decreased expression of ALAS2 mRNAdecreases expression 15122651
15120971
D001554 Benzene Benzene affects the expression of ALAS2 mRNAaffects expression 15878777
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALAS2 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALAS2 mRNAaffects cotreatment|increases expression 18164116
D004958 Estradiol Estradiol results in increased expression of ALAS2 mRNAincreases expression 16684588
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALAS2 mRNAaffects cotreatment|increases expression 17942748
D006418 Heme ALAS2 protein results in increased chemical synthesis of Hemeincreases chemical synthesis 16892088
D006581 Hexachlorobenzene Hexachlorobenzene results in increased expression of ALAS2 mRNAincreases expression 15159207
C051890 irinotecan irinotecan metabolite results in increased expression of ALAS2 mRNAincreases expression 15956246
C051890 irinotecan irinotecan results in increased expression of ALAS2 mRNAincreases expression 15956246
D007501 Iron Iron results in increased expression of ALAS2 mRNAincreases expression 16424395
D010126 Ozone Ozone results in decreased expression of ALAS2 mRNAdecreases expression 12763052
D010615 Phenacetin Phenacetin results in increased expression of ALAS2 mRNAincreases expression 17082564
C030299 phenylhydrazine phenylhydrazine results in increased expression of ALAS2 mRNAincreases expression 17082564
C006253 pirinixic acid pirinixic acid results in decreased expression of ALAS2 mRNAdecreases expression 20059764
15302862
17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of ALAS2 mRNA]decreases expression|increases reaction 20059764
C025299 polyphenols polyphenols results in decreased expression of ALAS2 mRNAdecreases expression 16293270
D011374 Progesterone Progesterone affects the expression of ALAS2 mRNAaffects expression 17251523
D020849 Raloxifene Raloxifene affects the expression of ALAS2 mRNAaffects expression 16079270
C017947 sodium arsenite sodium arsenite results in decreased expression of ALAS2 mRNAdecreases expression 17682005
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALAS2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ALAS2 mRNAdecreases expression 16466705
16054898
C025643 vinclozolin vinclozolin affects the expression of ALAS2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6815322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9618653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.7819825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 6.7811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7814692618
MESH:D000236 Adenoma beta-Naphthoflavone 6.5519389873
MESH:D000236 Adenoma Diethylnitrosamine 6.556695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.2817620307 19061943 17162532 19052882 18056438 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.2816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.2816835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7317306315 16712894
MESH:D000419 Albuminuria Raloxifene 4.4317451421 17308373
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.4816640825
MESH:D000544 Alzheimer Disease Iron 6.5516563566 16640825
MESH:D000544 Alzheimer Disease Ozone 6.5515513908
MESH:D000544 Alzheimer Disease Raloxifene 6.5515800139
MESH:D000740 Anemia Iron 20.0816566752 16434484
MESH:D000740 Anemia Phenacetin 20.082444515
MESH:D000740 Anemia phenylhydrazine 20.082444515
MESH:D000740 Anemia Tetrachlorodibenzodioxin 20.0811748828
MESH:D000741 Anemia, Aplastic Benzene 4.2414761424 17661222 11369114
MESH:D000743 Anemia, Hemolytic Phenacetin 10.531949026 17698508 17082564
MESH:D000743 Anemia, Hemolytic phenylhydrazine 10.5317082564 17084956 17698508
MESH:D018798 Anemia, Iron-Deficiency Iron 4.5017375513 17162259 17163184 16569441 17147795
MESH:D000756 Anemia, Sideroblastic marker/mechanism 16716198 16892088
MESH:D000756 Anemia, Sideroblastic Iron 4.6616910769
MESH:D000799 Angioedema Acetaminophen 11.4510982225
MESH:D000799 Angioedema Astemizole 11.452883202
MESH:D001008 Anxiety Disorders vinclozolin 3.5019015723
MESH:D001145 Arrhythmias, Cardiac Iron 4.2216604332
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5615885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5215570426
MESH:D001249 Asthma Ozone 2.5916373670 17854713
MESH:D001260 Ataxia Telangiectasia Iron 5.2815336622
MESH:D050197 Atherosclerosis Iron 3.6116640825 16632123
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Iron 2.1417352947
MESH:D001424 Bacterial Infections Iron 5.0216640825
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.3716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.3719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D001855 Bone Marrow Diseases Benzene 5.0616183116
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1717868700
MESH:D001930 Brain Injuries Progesterone 10.4015845082 15380490 15665606
MESH:D001930 Brain Injuries Raloxifene 10.4016580743
MESH:D001943 Breast Neoplasms Benzene 3.6617162533 11921183
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.6617474063
MESH:D001943 Breast Neoplasms Estradiol 3.6617261762 19861407 14630087 17018787 16675129 18497071 17289903 12948864
MESH:D001943 Breast Neoplasms Hexachlorobenzene 3.6615061365 12709520
MESH:D001943 Breast Neoplasms Progesterone 3.6615562024 17614352 16175315
MESH:D001943 Breast Neoplasms Raloxifene 3.6617595753 15572757 17440819 16912660 17261762 17242785 16837676 17049068 15775269 15758505 17952589 17893378
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6620435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5415516495 19059883 14754758 18315731 18417511 17626835 16777450
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1711589617
MESH:D002100 Cachexia Ozone 4.5716183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2916111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.0216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.023084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.0215553829 16217749 14691202 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.0219822196 20935162 17978847 18785209 19208518 10737359 17761372 16807293 17173139 18971187 11831363 18665156 21159647 19519916 19701751 20084675 19171122 19418558 16779866 19394651 18506893 19335982 16328049 3581430 19052882 20432363 18393292 18978308 20524982 18691550 3084413 16681979 16502159 18056438 18210153 17428255 17138121 19383236 20007298 16540662 16288022 20214788 19539802 18494052 10672840 16830150 17055752 16935385 20101231 19919837 20727157 20514400 19107877 20512989 16878318 16569478 17162532 16698587 18788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.0216924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.0215276417 17306315 16507464
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9712490120
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3318572023
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.9217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2716120746 18670907 18850075
MESH:D009202 Cardiomyopathies Iron 3.9316640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.4016604332
MESH:D002318 Cardiovascular Diseases Raloxifene 3.3315775269
MESH:D002386 Cataract Acetaminophen 2.4810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.076135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.077505956 17174075 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.0718566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.0720056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.8419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3217333356 17681005 11677210 16919318 15861022 16105132 17110522
MESH:D002779 Cholestasis pirinixic acid 7.3219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0312621046 15340226 15668235 8697196 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.4515800139
MESH:D003110 Colonic Neoplasms irinotecan 5.8717725105 17287894
MESH:D003110 Colonic Neoplasms Iron 5.8716640825
MESH:D003110 Colonic Neoplasms polyphenols 5.8716293270
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6420501625
MESH:D015179 Colorectal Neoplasms irinotecan 2.6416391804 15273666 17159606 16303861 18509181 18259882 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9114669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7410525206
MESH:D019465 Craniofacial Abnormalities Benzene 3.7415643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7420055451 15322242 10048152
MESH:D003456 Cryptorchidism vinclozolin 4.1714966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8518551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9315213294
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0217474826
MESH:D003872 Dermatitis Benzene 4.6015902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003920 Diabetes Mellitus Iron 4.3116640825 16604332
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.3116506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.9320387270
MESH:D003924 Diabetes Mellitus, Type 2 Iron 6.9316506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.9317107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.5219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 8.5215920148 17308373 17451421
MESH:D003929 Diabetic Neuropathies Progesterone 4.3217187935
MESH:D004244 Dizziness Astemizole 6.293105558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.4621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.4612540782 14725611 11743745 11461765 17906064 16109766 11739529 16781746 18071297 19416960 14550746 11287661 18713872 19739265 12705907 16081117 12153990 10915739 12958197 16177239 19923254 15968718 12392966 19085960 16227642 11834606 15619225 11421492 19370779 17562736 10774834 16393943 14986274 2444490 16485898 10663392 11529661 19164858 12594235 17522070 19420014
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.4619107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 11.4619370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.4620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:D004487 Edema pirinixic acid 10.5312083418
MESH:D004487 Edema Raloxifene 10.5315860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.5311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7318230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.4212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.4217692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.4215845917
MESH:D016889 Endometrial Neoplasms Estradiol 2.8719148513 18566989 11473722
MESH:D004715 Endometriosis Progesterone 8.4316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.439294722 10568697
MESH:D004802 Eosinophilia Astemizole 4.631355641
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9416302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.2712903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8911564622
MESH:D005234 Fatty Liver arsenic trioxide 28.6915073043
MESH:D005234 Fatty Liver Diethylnitrosamine 28.6920387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.6915345470
MESH:D005234 Fatty Liver Iron 28.6916640825
MESH:D005234 Fatty Liver pirinixic acid 28.6919236843 20131406
MESH:D005234 Fatty Liver Raloxifene 28.6917473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.7820067830
MESH:D005499 Folliculitis Astemizole 5.741671328
MESH:D005621 Friedreich Ataxia Iron 5.2616604332 16640825
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1016904648
MESH:D005756 Gastritis Acetaminophen 3.5016983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7616973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1316417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5116452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2410048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.4211110106
MESH:D006333 Heart Failure pirinixic acid 2.4320558911
MESH:D006402 Hematologic Diseases Benzene 4.4916183116
MESH:D006432 Hemochromatosis Iron 4.3716574947 16640825 17053826 17255318 16604332 17236123
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006486 Hemosiderosis Iron 5.0416604332
MESH:D006525 Hepatitis, Viral, Human Iron 5.3016640825
MESH:D006527 Hepatolenticular Degeneration Iron 4.7717182432
MESH:D006529 Hepatomegaly Iron 13.5116890145
MESH:D006529 Hepatomegaly pirinixic acid 13.5118467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.5115340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8615709030
MESH:D015658 HIV Infections Iron 3.5816597321
MESH:D006689 Hodgkin Disease sodium arsenite 3.0112676792
MESH:D019584 Hot Flashes Estradiol 3.5817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.878697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.5716870215
MESH:D006943 Hyperglycemia pirinixic acid 3.0320558911
MESH:D006973 Hypertension Benzene 8.3317940673
MESH:D006973 Hypertension Raloxifene 8.3317577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.3318850075 18670907
MESH:D007006 Hypogonadism Iron 4.2816640825
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6416945680 16569931
MESH:D007037 Hypothyroidism Iron 4.9116640825
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2315869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.5517937319
MESH:D007248 Infertility, Male sodium arsenite 10.5512646999 15346721
MESH:D007248 Infertility, Male vinclozolin 10.5516467254
MESH:D007249 Inflammation Diethylnitrosamine 14.9618785209
MESH:D007249 Inflammation Heme 14.9612649161
MESH:D007249 Inflammation polyphenols 14.9616366677
MESH:D007249 Inflammation Progesterone 14.9615869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.9612200463 12878042
MESH:D007333 Insulin Resistance Estradiol 6.8316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.8316306350
MESH:D019189 Iron Metabolism Disorders Iron 4.8717163184
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1816580747
MESH:D007674 Kidney Diseases Acetaminophen 9.4712587719 15629191
MESH:D007674 Kidney Diseases Estradiol 9.4715618244
MESH:D007674 Kidney Diseases sodium arsenite 9.4720008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 6.9016705839
MESH:D007680 Kidney Neoplasms Estradiol 6.9015610895
MESH:D007889 Leiomyoma Raloxifene 4.3316973256
MESH:D007938 Leukemia arsenic trioxide 6.2915070760
MESH:D007938 Leukemia Benzene 6.2918335105 15935818 14694614 17119257
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6417077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.1819077051
MESH:D007951 Leukemia, Myeloid Benzene 9.1817506065
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0016968895 17050201 19850784 20471514 16467208
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.0019478238
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1017869043 17217047 12679006 11468182 15622746 15336539 16823087 15748426 19225113 19642359 16966277 16331271 17649720 11161223 12712474 16330433 17712046 12018890 9834237 19035177 16891316 16112521 15213294 17107899 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1916882451
MESH:D020961 Lewy Body Disease Iron 5.2616563566
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5616417039
MESH:D017513 Lichen Nitidus Astemizole 6.292563723
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.6419638242 20032147 18665156 18522880 18407596
MESH:D008103 Liver Cirrhosis Iron 6.6416640825
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.2614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.2615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.2612878042
MESH:D008107 Liver Diseases Acetaminophen 6.3019014921 12969438 19460945 16611625 12587719 19784758 11587558 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 6.3017034775
MESH:D008107 Liver Diseases polyphenols 6.3016698588
MESH:D008108 Liver Diseases, Alcoholic Iron 4.8316737972 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0817185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 24.847678174
MESH:D008113 Liver Neoplasms arsenic trioxide 24.8414682389
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 24.8421295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.8419256749 15885732 20501860 18977376 21167192 19850985 21047994 20434301 20118626 19255062 20405173 20583210 10737359 19996281 20492335 19294768 18978307 19690152 19090486 19073162 2422723 18644402 2862719 21278145 9163691 12771043 19642983 18754104 19833225 18648771 21071580 19427195 19551842 19254457 16942905 19426721 20101389 19499222 20452335 15175105 19638242 19812893 20137499 12112319
MESH:D008113 Liver Neoplasms Iron 24.8420302851 16640825
MESH:D008113 Liver Neoplasms pirinixic acid 24.8416377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 24.8416712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.8416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 26.666135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 26.6620377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 26.6612562636
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 26.6618164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 26.663124819 18775883 17174075 19126423 17942915 18253720 16842330 18164116 9362446 18544905 19519916 18079962 19004024 16267830 18093689 19009564 2563599 19539802 17854601 18308698 21159647 18282651
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 26.661423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 26.6612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 8.1415213294
MESH:D008133 Long QT Syndrome Astemizole 8.1418472280 11989578
MESH:D008171 Lung Diseases Ozone 7.148266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 7.1419095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.6414698565
MESH:D055370 Lung Injury Ozone 3.6820417186
MESH:D008175 Lung Neoplasms arsenic trioxide 10.3811798837 19825857
MESH:D008175 Lung Neoplasms Benzene 10.3812562636
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.3820512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Iron 10.3816640825
MESH:D008175 Lung Neoplasms Ozone 10.388597069 7614698
MESH:D008175 Lung Neoplasms sodium arsenite 10.3817077188 15276417 17306315 19931552 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.3819555203 11884234
MESH:D008223 Lymphoma Benzene 3.6217584886 17119257
MESH:D008268 Macular Degeneration Iron 3.8916640825
MESH:D008288 Malaria Astemizole 4.6316816845
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.2712562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 9.4311921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.4311408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.4317203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.3119453300
MESH:D008545 Melanoma sodium arsenite 2.0116487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4019513568
MESH:D008679 Metaplasia Ozone 4.9310496685
MESH:D008708 Methemoglobinemia Phenacetin 4.7916296465 3537620 4834387 1949026
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3815863610
MESH:D052016 Mucositis irinotecan 4.8417159606
MESH:D009101 Multiple Myeloma arsenic trioxide 11.5111468182 15949261 14977855 19417148 19549372
MESH:D009101 Multiple Myeloma Benzene 11.5117119195
MESH:D009101 Multiple Myeloma Raloxifene 11.5116497877
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.5017086897
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009181 Mycoses Iron 5.3016640825
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0516105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Iron 8.7216604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.7212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.4916810080
MESH:D015428 Myocardial Reperfusion Injury Iron 13.4916604332
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.4916411023
MESH:D009232 Myxoma Raloxifene 5.3816343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.6918551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7916624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.733581430 9029167
MESH:D009362 Neoplasm Metastasis irinotecan 5.7318259882
MESH:D009369 Neoplasms pirinixic acid 4.6617405874
MESH:D009369 Neoplasms sodium arsenite 4.6611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5020056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5617289903
MESH:D009404 Nephrotic Syndrome Iron 4.3717178036
MESH:D009421 Nervous System Malformations Estradiol 8.9111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9114600291
MESH:D009436 Neural Tube Defects arsenic trioxide 11.6010525206
MESH:D009436 Neural Tube Defects Benzene 11.6015643154
MESH:D009436 Neural Tube Defects sodium arsenite 11.6012854658
MESH:D009447 Neuroblastoma irinotecan 3.398761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 13.3018514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 13.3020387270
MESH:D019636 Neurodegenerative Diseases Iron 13.3016604332 17296847
MESH:D017599 Neuroectodermal Tumors irinotecan 4.568761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9420387270
MESH:D009759 Nystagmus, Pathologic Astemizole 6.296135121
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.6616049721
MESH:D009784 Occupational Diseases Benzene 8.6615576619 15913788 15612468 17479406 17119257 16737584 15727169 17178637 15935809
MESH:D010003 Osteoarthritis Iron 3.8616640825
MESH:D010024 Osteoporosis Iron 7.2116640825 16648989
MESH:D010024 Osteoporosis Raloxifene 7.2115775268 19059307 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0715579764 15758505 17893378 17823083
MESH:D010051 Ovarian Neoplasms arsenic trioxide 14.4119769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Benzene 14.4112562636
MESH:D010051 Ovarian Neoplasms Estradiol 14.4119401270
MESH:D010051 Ovarian Neoplasms Progesterone 14.4116525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.4115276417 17306315
MESH:D010146 Pain Acetaminophen 2.2516870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.0715580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.0716540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010212 Papilloma Iron 4.3112065085
MESH:D010235 Paraganglioma arsenic trioxide 4.0019927285
MESH:D020447 Parasomnias Iron 5.8517352947
MESH:D010300 Parkinson Disease Iron 3.2616640825 16563566
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D010538 Peritonitis Ozone 3.9616369182
MESH:D010900 Pituitary Diseases Iron 5.5016604332
MESH:D011014 Pneumonia Ozone 4.2218929643 18007984 18381685
MESH:D011041 Poisoning Iron 4.1316604332
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 17.839918132
MESH:D017119 Porphyria Cutanea Tarda Iron 17.8316640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 17.8318163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.412563599
MESH:D011225 Pre-Eclampsia Iron 4.2916640825
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9111896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.9118042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.7618220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7320887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1219131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.1216740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1216536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1216039940
MESH:D011472 Prostatitis vinclozolin 4.7618629315
OMIM:300752 PROTOPORPHYRIA, ERYTHROPOIETIC, X-LINKED DOMINANT marker/mechanism
MESH:D011528 Protozoan Infections Iron 5.8516640825
MESH:D011537 Pruritus Ethinyl Estradiol 3.1415861022 16919318
MESH:D011693 Purpura Raloxifene 5.3815770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.3019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012148 Restless Legs Syndrome Iron 4.4216930377
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 5.2610822083
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8018045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7916646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4218551238
MESH:D012878 Skin Neoplasms Iron 9.0812065085
MESH:D012878 Skin Neoplasms sodium arsenite 9.0819524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.0816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7716709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.1115862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6612854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.6317007042
MESH:D013274 Stomach Neoplasms Benzene 4.6312562636
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.6318456281
MESH:D013274 Stomach Neoplasms irinotecan 4.6315723263
MESH:D020521 Stroke Raloxifene 3.6916837676
MESH:D013398 Sudden Infant Death Iron 5.2816640825
MESH:D013436 Sulfhemoglobinemia Phenacetin 6.38978859
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.0817997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013953 Thymus Neoplasms Benzene 4.7810850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7312697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.7619014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.767505956
MESH:D013978 Tibial Fractures Estradiol 13.1419048282
MESH:D013978 Tibial Fractures Raloxifene 13.1419048282
MESH:D016171 Torsades de Pointes arsenic trioxide 10.0615213294
MESH:D016171 Torsades de Pointes Astemizole 10.068256756 9583453
MESH:D014376 Tuberculosis Iron 3.9816597321
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.1216049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.1211780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 15.1211144890
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 15.1217572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 15.1216712894 11723127 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1510091137
MESH:D014581 Urticaria Acetaminophen 8.5010982225
MESH:D014581 Urticaria Astemizole 8.502859714 3080510 1683191 2883202 2568189 2565098 2885854 1976298 2147912 3134034 3097109 2568013
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.6211813266
MESH:D014594 Uterine Neoplasms Benzene 9.0212562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.0214692618
MESH:D014652 Vascular Diseases sodium arsenite 4.2517056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.0416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3814671159 15869587
MESH:D014717 Vertigo Astemizole 6.293105558
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
MESH:D014947 Wounds and Injuries Heme 5.1412649161
MESH:C536761 X-linked sideroblastic anemia marker/mechanism
Pathway ID Pathway Name
KEGG:00260 Glycine, serine and threonine metabolism
KEGG:01100 Metabolic pathways
REACT:9431 Metabolism of porphyrins
KEGG:00860 Porphyrin and chlorophyll metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24689
    • No data
    Releated disease ID Related disease Name
    PA445388Porphyrias
    Releated drug ID Related drug Name
    PA449789glycine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00145 - Glycine Dietary supplement;Micronutrient;Non-Essential Amino Acids;Glycine Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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