AutismKB 2.0

Annotation Detail for MECOM


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Basic Information Top
Gene Symbol:MECOM ( AML1-EVI-1,EVI1,MDS1,MDS1-EVI1,MGC163392,MGC97004,PRDM3 )
Gene Full Name: MDS1 and EVI1 complex locus
Band: 3q26.2
Quick LinksEntrez ID:2122; OMIM: 165215; Uniprot ID:EVI1_HUMAN; ENSEMBL ID: ENSG00000085276,ENSG00000244102; HGNC ID: 3498
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa05220Chronic myeloid leukemia
hsa05200Pathways in cancer
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers of haematopoietic and lymphoid tissues
Cancers
H00004Chronic myeloid leukemia (CML)
Desease IDDesease Name
1720Fanconi's anemia
2051Leukemia
No data
Desease Name
Diastolic blood pressure
Nasopharyngeal carcinoma
Systolic blood pressure
Serum magnesium levels
Desease Name
3q21q26 syndrome
Myelodysplasia syndrome-1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in decreased expression of MECOM mRNAdecreases expression 20458559
D002117 Calcitriol Calcitriol results in decreased expression of MECOM mRNAdecreases expression 16002434
D006918 Hydroxyurea Hydroxyurea results in increased expression of MECOM protein mutant formincreases expression 16532439
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of MECOM mRNAincreases expression 12634122
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MECOM mRNAaffects binding|decreases expression|increases activity 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MECOM mRNAincreases expression 11489354
D014212 Tretinoin Tretinoin results in increased stability of and results in increased expression of MECOM mRNAincreases expression|increases stability 16014322
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2411752688 15322242 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3411798837 19825857
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2616835633
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 24.4316206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 24.4319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 24.4312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 24.4316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Calcitriol 1.8811237771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8816873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1815073043 14691202 11135700 15553829 16217749
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.181917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.0011237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.0016096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D002386 Cataract Tretinoin 3.2417460283
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 4.182727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0916354765 8697196 15668235 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 6.099407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8910525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8915322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.899211117 10589399 9125849 17551590 14991402 16925845 9664655 8800419 9142499 9224671
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.4718230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 13.4718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.2615138306
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.5211564622
MESH:D005124 Eye Abnormalities Tretinoin 9.5216938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 8.6715073043
MESH:D005234 Fatty Liver pirinixic acid 8.6720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8420067830
MESH:D005355 Fibrosis Tretinoin 9.8417994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.979664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly pirinixic acid 9.4816221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4815340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4915340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.4316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.8916580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.8915992940 17551590
MESH:D007938 Leukemia arsenic trioxide 6.7515070760
MESH:D007938 Leukemia Tretinoin 6.7517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 17.8519077051
MESH:D007951 Leukemia, Myeloid Hydroxyurea 17.8516532439
MESH:D007951 Leukemia, Myeloid Tretinoin 17.8516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0219850784 16467208 16968895 17050201 20471514
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0217596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.2017649720 17107899 16823087 16331271 16112521 17869043 19035177 19642359 19075265 11161223 9834237 16966277 11468182 12679006 15213294 16330433 16891316 15748426 12712474 12018890 17712046 15622746 19225113 17217047 15336539
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.2017339181 16766008 17107899 17506722 16935935 17217047 17361223 16140955 19035177 19225113 17649720 15748426 19642359 16331271 17301526 17712046 16891316 17368321 16823087 12679006 17294898 19075265 9834237 16788101 19029980
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5418397230 16248980
MESH:D008113 Liver Neoplasms arsenic trioxide 7.8714682389
MESH:D008113 Liver Neoplasms pirinixic acid 7.8720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.3420377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3611798837 19825857
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3611884234 19555203
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 6.2917671175
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2915949261 19549372 19417148 11468182 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.8716105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.8717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009303 Nasopharyngeal Neoplasms marker/mechanism 20512145
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009369 Neoplasms pirinixic acid 5.3117405874
MESH:D009369 Neoplasms Tretinoin 5.3116594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.6314600291
MESH:D009421 Nervous System Malformations Tretinoin 10.639125849
MESH:D009436 Neural Tube Defects arsenic trioxide 7.8710525206
MESH:D009436 Neural Tube Defects Tretinoin 7.879142499
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1116624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1116936753
MESH:D010146 Pain Tretinoin 3.1316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5715580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.5715976015
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911896295 11118676 11222880 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1815572423
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3319131511
MESH:D011471 Prostatic Neoplasms Calcitriol 3.3312479363 16289102 15754350 18247401 16644109
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9416192470
MESH:D012878 Skin Neoplasms Tretinoin 5.9416467112
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5117007042
MESH:D013274 Stomach Neoplasms Tretinoin 2.5117261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.9219014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.9217045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5711780464 12845720 20435036 12973940
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
Pathway ID Pathway Name
KEGG:05220 Chronic myeloid leukemia
KEGG:04010 MAPK signaling pathway
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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